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Conserved domains on  [gi|6324108|ref|NP_014178|]
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ribonuclease P/MRP protein subunit POP1 [Saccharomyces cerevisiae S288C]

Protein Classification

ribonucleases P/MRP protein subunit POP1( domain architecture ID 10536688)

ribonucleases P/MRP protein subunit POP1 is a component of both ribonuclease P and MRP ribonuclease, which cleave tRNA molecules by their 5'-ends and pre-rRNA sequences, respectively

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
POP1 pfam06978
Ribonucleases P/MRP protein subunit POP1; This family represents a conserved region ...
 62-300 6.51e-103

Ribonucleases P/MRP protein subunit POP1; This family represents a conserved region approximately 150 residues long located towards the N-terminus of the POP1 subunit that is common to both the RNase MRP and RNase P ribonucleoproteins (EC:3.1.26.5). These RNA-containing enzymes generate mature tRNA molecules by cleaving their 5' ends.


:

Pssm-ID: 429227  Cd Length: 211  Bit Score: 317.68  E-value: 6.51e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324108     62 FISSRQFEVKQLQLAMHNSKAASSTRIFQALPRKLRRRTASHNVRRIPKRMRNRALREMRKSDQQDVlkgsSASSRKAHG 141
Cdd:pfam06978   1 FVKSREFEIKALENAMKKSKNASSTRAFQSLPRSLRRRTASHNVKRVPKRLRNRALREMAEDNTPTV----TSRKRKKKG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324108    142 LNAKQLYKARMSIKLLRLASKSTSMKLSMPPEVTSSNchvrqkiktlkrmikesstanPNIKLLNNRMGSYDCTGVNELA 221
Cdd:pfam06978  77 LTGRKRYRLETAKKLLRLAAKKKAMKALALPEKKDKD---------------------NEAPKLNNVRGSYDKIGKNKLA 135

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6324108    222 PIPKGRVKYTKRQKHFAWLPTHIWNAKRSHMMKRWGYQMVWAPTQKCFKLTHRLGGdtcsSDGALCMDSSYIGTIIVKD 300
Cdd:pfam06978 136 TPPKGRIKYRKRQRNKTWLPTHLWHAKRAHMTKPWGFAIPLTPTQKCYRPTHRAAG----SRGAVAWDTSYMSTIILEG 210
POPLD pfam08170
POPLD (NUC188) domain; This domain is found in POP1-like nucleolar proteins.
 555-661 1.29e-37

POPLD (NUC188) domain; This domain is found in POP1-like nucleolar proteins.


:

Pssm-ID: 462391  Cd Length: 92  Bit Score: 135.38  E-value: 1.29e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324108    555 DWIVVLPWFWLLPLWHLLNRIPrMYHIGLRQFQQIQYENKQLYFPDDYPFTQLGYIENSFYKKEAsKTKWDRKPMGKRIN 634
Cdd:pfam08170   1 GWDLILPWGWALPFWYSLVYRG-VRVGGLRERRQLAFESGKPYFPDDYPDTEAGWEEELERKKEL-EEKWFRKPPAKRVN 78

                          90       100
                  ....*....|....*....|....*..
gi 6324108    635 FEKikdihntklpaysGEIGDFFSSDW 661
Cdd:pfam08170  79 YLK-------------GEIGSPFACDW 92
 
Name Accession Description Interval E-value
POP1 pfam06978
Ribonucleases P/MRP protein subunit POP1; This family represents a conserved region ...
 62-300 6.51e-103

Ribonucleases P/MRP protein subunit POP1; This family represents a conserved region approximately 150 residues long located towards the N-terminus of the POP1 subunit that is common to both the RNase MRP and RNase P ribonucleoproteins (EC:3.1.26.5). These RNA-containing enzymes generate mature tRNA molecules by cleaving their 5' ends.


Pssm-ID: 429227  Cd Length: 211  Bit Score: 317.68  E-value: 6.51e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324108     62 FISSRQFEVKQLQLAMHNSKAASSTRIFQALPRKLRRRTASHNVRRIPKRMRNRALREMRKSDQQDVlkgsSASSRKAHG 141
Cdd:pfam06978   1 FVKSREFEIKALENAMKKSKNASSTRAFQSLPRSLRRRTASHNVKRVPKRLRNRALREMAEDNTPTV----TSRKRKKKG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324108    142 LNAKQLYKARMSIKLLRLASKSTSMKLSMPPEVTSSNchvrqkiktlkrmikesstanPNIKLLNNRMGSYDCTGVNELA 221
Cdd:pfam06978  77 LTGRKRYRLETAKKLLRLAAKKKAMKALALPEKKDKD---------------------NEAPKLNNVRGSYDKIGKNKLA 135

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6324108    222 PIPKGRVKYTKRQKHFAWLPTHIWNAKRSHMMKRWGYQMVWAPTQKCFKLTHRLGGdtcsSDGALCMDSSYIGTIIVKD 300
Cdd:pfam06978 136 TPPKGRIKYRKRQRNKTWLPTHLWHAKRAHMTKPWGFAIPLTPTQKCYRPTHRAAG----SRGAVAWDTSYMSTIILEG 210
POPLD pfam08170
POPLD (NUC188) domain; This domain is found in POP1-like nucleolar proteins.
 555-661 1.29e-37

POPLD (NUC188) domain; This domain is found in POP1-like nucleolar proteins.


Pssm-ID: 462391  Cd Length: 92  Bit Score: 135.38  E-value: 1.29e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324108    555 DWIVVLPWFWLLPLWHLLNRIPrMYHIGLRQFQQIQYENKQLYFPDDYPFTQLGYIENSFYKKEAsKTKWDRKPMGKRIN 634
Cdd:pfam08170   1 GWDLILPWGWALPFWYSLVYRG-VRVGGLRERRQLAFESGKPYFPDDYPDTEAGWEEELERKKEL-EEKWFRKPPAKRVN 78

                          90       100
                  ....*....|....*....|....*..
gi 6324108    635 FEKikdihntklpaysGEIGDFFSSDW 661
Cdd:pfam08170  79 YLK-------------GEIGSPFACDW 92
 
Name Accession Description Interval E-value
POP1 pfam06978
Ribonucleases P/MRP protein subunit POP1; This family represents a conserved region ...
 62-300 6.51e-103

Ribonucleases P/MRP protein subunit POP1; This family represents a conserved region approximately 150 residues long located towards the N-terminus of the POP1 subunit that is common to both the RNase MRP and RNase P ribonucleoproteins (EC:3.1.26.5). These RNA-containing enzymes generate mature tRNA molecules by cleaving their 5' ends.


Pssm-ID: 429227  Cd Length: 211  Bit Score: 317.68  E-value: 6.51e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324108     62 FISSRQFEVKQLQLAMHNSKAASSTRIFQALPRKLRRRTASHNVRRIPKRMRNRALREMRKSDQQDVlkgsSASSRKAHG 141
Cdd:pfam06978   1 FVKSREFEIKALENAMKKSKNASSTRAFQSLPRSLRRRTASHNVKRVPKRLRNRALREMAEDNTPTV----TSRKRKKKG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324108    142 LNAKQLYKARMSIKLLRLASKSTSMKLSMPPEVTSSNchvrqkiktlkrmikesstanPNIKLLNNRMGSYDCTGVNELA 221
Cdd:pfam06978  77 LTGRKRYRLETAKKLLRLAAKKKAMKALALPEKKDKD---------------------NEAPKLNNVRGSYDKIGKNKLA 135

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6324108    222 PIPKGRVKYTKRQKHFAWLPTHIWNAKRSHMMKRWGYQMVWAPTQKCFKLTHRLGGdtcsSDGALCMDSSYIGTIIVKD 300
Cdd:pfam06978 136 TPPKGRIKYRKRQRNKTWLPTHLWHAKRAHMTKPWGFAIPLTPTQKCYRPTHRAAG----SRGAVAWDTSYMSTIILEG 210
POPLD pfam08170
POPLD (NUC188) domain; This domain is found in POP1-like nucleolar proteins.
 555-661 1.29e-37

POPLD (NUC188) domain; This domain is found in POP1-like nucleolar proteins.


Pssm-ID: 462391  Cd Length: 92  Bit Score: 135.38  E-value: 1.29e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324108    555 DWIVVLPWFWLLPLWHLLNRIPrMYHIGLRQFQQIQYENKQLYFPDDYPFTQLGYIENSFYKKEAsKTKWDRKPMGKRIN 634
Cdd:pfam08170   1 GWDLILPWGWALPFWYSLVYRG-VRVGGLRERRQLAFESGKPYFPDDYPDTEAGWEEELERKKEL-EEKWFRKPPAKRVN 78

                          90       100
                  ....*....|....*....|....*..
gi 6324108    635 FEKikdihntklpaysGEIGDFFSSDW 661
Cdd:pfam08170  79 YLK-------------GEIGSPFACDW 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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