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Conserved domains on  [gi|6324109|ref|NP_014179|]
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adenylosuccinate synthase [Saccharomyces cerevisiae S288C]

Protein Classification

adenylosuccinate synthetase( domain architecture ID 10464973)

GTP-dependent adenylosuccinate synthetase catalyzes the formation of adenylosuccinate from L-aspartate and IMP, the first step in the de novo biosynthesis of AMP

CATH:  1.10.300.10
EC:  6.3.4.4
Gene Ontology:  GO:0004019|GO:0005525|GO:0003688|GO:0000287
PubMed:  6347525|10218106
SCOP:  4003995

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
4-428 0e+00

Adenylosuccinate synthetase;


:

Pssm-ID: 459912  Cd Length: 417  Bit Score: 729.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109      4 VVLGSQWGDEGKGKLVDLLVGKYDIVARCAGGNNAGHTIVVDGVKYDFHMLPSGLVNPNCQNLLGNGVVIHVPSFFKELE 83
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAEDADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109     84 TLEAKGLKnARSRLFVSSRAHLVFDFHQVTDKLRElelsgRSKDGKNIGTTGKGIGPTYSTKASRSGLRVHHLVNdqpga 163
Cdd:pfam00709  81 ELEERGID-VPDRLFISDRAHLILPYHKALDGLRE-----EARGKKKIGTTGRGIGPAYSDKAARRGIRVGDLLD----- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    164 WEEFVARYKRLLETRRQRYGDF---EYDFEAKLAEYKKLREQLKPFVVDSVVFMHNAIEAKKKILVEGANALMLDIDFGT 240
Cdd:pfam00709 150 PEVFREKLEALLELKNKLLEKLygePLDVEEELEELLEYAERLKPYVVDTSYFLNKALKEGKKILFEGAQGTLLDIDHGT 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    241 YPYVTSSNTGIGGVLTGLGIPPRTIDEIYGVVKAYTTRVGEGPFPTEQLNENGEKLQTIGAEFGVTTGRKRRCGWLDLVV 320
Cdd:pfam00709 230 YPYVTSSNTTAGGACTGLGIGPTKIDEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVA 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    321 LKYSTLINGYTSLNITKLDVLDTFKEIPVGISYSIQGKKLDLFPEDLNILGKVEVEYKVLPGWDQDITKITKYEDLPENA 400
Cdd:pfam00709 310 LRYAVRINGVTGLALTKLDVLDGLDEIKVCVAYELDGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENA 389

                         410       420
                  ....*....|....*....|....*...
gi 6324109    401 KKYLKYIEDFVGVPVEWVGTGPARESML 428
Cdd:pfam00709 390 RKYVEFIEELLGVPIKIISVGPDREQTI 417
 
Name Accession Description Interval E-value
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
4-428 0e+00

Adenylosuccinate synthetase;


Pssm-ID: 459912  Cd Length: 417  Bit Score: 729.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109      4 VVLGSQWGDEGKGKLVDLLVGKYDIVARCAGGNNAGHTIVVDGVKYDFHMLPSGLVNPNCQNLLGNGVVIHVPSFFKELE 83
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAEDADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109     84 TLEAKGLKnARSRLFVSSRAHLVFDFHQVTDKLRElelsgRSKDGKNIGTTGKGIGPTYSTKASRSGLRVHHLVNdqpga 163
Cdd:pfam00709  81 ELEERGID-VPDRLFISDRAHLILPYHKALDGLRE-----EARGKKKIGTTGRGIGPAYSDKAARRGIRVGDLLD----- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    164 WEEFVARYKRLLETRRQRYGDF---EYDFEAKLAEYKKLREQLKPFVVDSVVFMHNAIEAKKKILVEGANALMLDIDFGT 240
Cdd:pfam00709 150 PEVFREKLEALLELKNKLLEKLygePLDVEEELEELLEYAERLKPYVVDTSYFLNKALKEGKKILFEGAQGTLLDIDHGT 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    241 YPYVTSSNTGIGGVLTGLGIPPRTIDEIYGVVKAYTTRVGEGPFPTEQLNENGEKLQTIGAEFGVTTGRKRRCGWLDLVV 320
Cdd:pfam00709 230 YPYVTSSNTTAGGACTGLGIGPTKIDEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVA 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    321 LKYSTLINGYTSLNITKLDVLDTFKEIPVGISYSIQGKKLDLFPEDLNILGKVEVEYKVLPGWDQDITKITKYEDLPENA 400
Cdd:pfam00709 310 LRYAVRINGVTGLALTKLDVLDGLDEIKVCVAYELDGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENA 389

                         410       420
                  ....*....|....*....|....*...
gi 6324109    401 KKYLKYIEDFVGVPVEWVGTGPARESML 428
Cdd:pfam00709 390 RKYVEFIEELLGVPIKIISVGPDREQTI 417
Adenylsucc_synt smart00788
Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine ...
 2-429 0e+00

Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine biosynthesis, by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. Adenylosuccinate synthetase has been characterized from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present - one involved in purine biosynthesis and the other in the purine nucleotide cycle. The crystal structure of adenylosuccinate synthetase from E. coli reveals that the dominant structural element of each monomer of the homodimer is a central beta-sheet of 10 strands. The first nine strands of the sheet are mutually parallel with right-handed crossover connections between the strands. The 10th strand is antiparallel with respect to the first nine strands. In addition, the enzyme has two antiparallel beta-sheets, comprised of two strands and three strands each, 11 alpha-helices and two short 3/10-helices. Further, it has been suggested that the similarities in the GTP-binding domains of the synthetase and the p21ras protein are an example of convergent evolution of two distinct families of GTP-binding proteins. Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known structures from E. coli reveals that the overall fold is very similar to that of the E. coli protein.


Pssm-ID: 197875  Cd Length: 417  Bit Score: 678.82  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109       2 VNVVLGSQWGDEGKGKLVDLLVGKYDIVARCAGGNNAGHTIVVDGVKYDFHMLPSGLVNPNCQNLLGNGVVIHVPSFFKE 81
Cdd:smart00788   1 VVVVVGAQWGDEGKGKIVDYLAEKADVVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNKKNVIGNGVVIDPEALFKE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109      82 LETLEAKGLkNARSRLFVSSRAHLVFDFHQVTDKLRElelsgrskdGKNIGTTGKGIGPTYSTKASRSGLRVHHLVNDqp 161
Cdd:smart00788  81 IEELEAKGV-DVKDRLFISDRAHLILPYHIALDKARE---------KARIGTTGRGIGPAYEDKVARRGIRVGDLFDE-- 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109     162 gawEEFVARYKRLLETRRQRYGDF----EYDFEAKLAEYKKLREQLKPFVVDSVVFMHNAIEAKKKILVEGANALMLDID 237
Cdd:smart00788 149 ---EVLREKLEELLDYKNFLLKKLygaePVDVEEILEELLEYAERLRPYVTDVSELLNEALKAGKKVLFEGAQGTLLDID 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109     238 FGTYPYVTSSNTGIGGVLTGLGIPPRTIDEIYGVVKAYTTRVGEGPFPTEQLNENGEKLQTIGAEFGVTTGRKRRCGWLD 317
Cdd:smart00788 226 HGTYPYVTSSNTTAGGAATGAGIGPTRIDRVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGTTTGRPRRCGWFD 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109     318 LVVLKYSTLINGYTSLNITKLDVLDTFKEIPVGISYSIQGKKLDLFPEDLNILGKVEVEYKVLPGWDQDITKITKYEDLP 397
Cdd:smart00788 306 AVLLRYAVRINGITGLALTKLDVLDGLDEIKVCVAYKLDGKIIDYFPADLEDLERCEPIYEELPGWKEDTTGVRSYEDLP 385

                          410       420       430
                   ....*....|....*....|....*....|..
gi 6324109     398 ENAKKYLKYIEDFVGVPVEWVGTGPARESMLH 429
Cdd:smart00788 386 ENAKKYIERIEELVGVPVSIISTGPDREQTIV 417
purA TIGR00184
adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, ...
 4-433 0e+00

adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272949  Cd Length: 425  Bit Score: 677.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109      4 VVLGSQWGDEGKGKLVDLLVGKYDIVARCAGGNNAGHTIVVDGVKYDFHMLPSGLVNPNCQNLLGNGVVIHVPSFFKELE 83
Cdd:TIGR00184   1 VVVGGQWGDEGKGKIVDLLADKPDIVARYQGGHNAGHTIVIDGVKYGLHLIPSGFLYPDAKLLIGNGVVVDPEVLLKEME 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109     84 TLEaKGLKNARSRLFVSSRAHLVFDFHQVTDKLRElelsgRSKDGKNIGTTGKGIGPTYSTKASRSGLRVHHLVNDQPgA 163
Cdd:TIGR00184  81 YLE-KRGISVRDRLFVSYRCHLILPYHKKLDKARE-----KSKLAKKIGTTGKGIGPAYEDKVARSGLRVGDLLDDEA-F 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    164 WEEFVARYKRLLETRRQRYGDFEYDFEAKLAEYKKLREQLKPFVVDSVVFMHNAIEAKKKILVEGANALMLDIDFGTYPY 243
Cdd:TIGR00184 154 AEKAKNILEYLNEQLVKYYKDEGVDYEKKLDEYMKYAEELKPFVVDVSVELNEALDEGEKVLFEGAQGTMLDIDYGTYPY 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    244 VTSSNTGIGGVLTGLGIPPRTIDEIYGVVKAYTTRVGEGPFPTEQLNENGEKLQTIGAEFGVTTGRKRRCGWLDLVVLKY 323
Cdd:TIGR00184 234 VTSSNTTAGGVATGVGIGPTKVDEVIGVFKAYTTRVGAGPFPTELSDEEGEKLGTKGAEFGTTTGRRRRCGWFDLVAARY 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    324 STLINGYTSLNITKLDVLDTFKEIPVGISYSIQGKKLDLFPEDLNILGKVEVEYKVLPGWDQDITKITKYEDLPENAKKY 403
Cdd:TIGR00184 314 ACRLNGATQLALTKLDVLDGIDEIKVCVAYRMKGEILELFPLDLKDLKGVEPIYETLPGWDKECTGVTEYSDLPENAKKY 393

                         410       420       430
                  ....*....|....*....|....*....|..
gi 6324109    404 LKYIEDFVGVPVEWVGTGPARESM--LHKEIK 433
Cdd:TIGR00184 394 IERIEELTGVPVTIISTGPEREQTidLRKELL 425
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
 2-431 0e+00

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439874  Cd Length: 423  Bit Score: 635.51  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    2 VNVVLGSQWGDEGKGKLVDLLVGKYDIVARCAGGNNAGHTIVVDGVKYDFHMLPSGLVNPNCQNLLGNGVVIHVPSFFKE 81
Cdd:COG0104   1 NVVVVGAQWGDEGKGKIVDLLAERADVVVRFQGGNNAGHTVVVGGKKFKLHLIPSGILRPGKTCVIGNGVVLDPEALLEE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   82 LETLEAKGLkNARSRLFVSSRAHLVFDFHQVTDKLRElelsgRSKDGKNIGTTGKGIGPTYSTKASRSGLRVHHLVNDqp 161
Cdd:COG0104  81 IDGLEARGV-DVRSRLRISERAHLILPYHRALDKARE-----EARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLLDP-- 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109  162 gawEEFVARYKRLLE----TRRQRYGDFEYDFEAKLAEYKKLREQLKPFVVDSVVFMHNAIEAKKKILVEGANALMLDID 237
Cdd:COG0104 153 ---EVLREKLEELLEyknfLLEKLYGAEPLDFEELLEEYLEYAERLKPYVADTSELLNEALKAGKKVLFEGAQGTLLDID 229

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109  238 FGTYPYVTSSNTGIGGVLTGLGIPPRTIDEIYGVVKAYTTRVGEGPFPTEQLNENGEKLQTIGAEFGVTTGRKRRCGWLD 317
Cdd:COG0104 230 HGTYPYVTSSNTTAGGACTGSGVGPTKIDRVIGVVKAYTTRVGEGPFPTELFDETGERLRERGHEFGTTTGRPRRCGWLD 309

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109  318 LVVLKYSTLINGYTSLNITKLDVLDTFKEIPVGISYSIQGKKLDLFPEDLNILGKVEVEYKVLPGWDQDITKITKYEDLP 397
Cdd:COG0104 310 AVALRYAVRINGLTGLALTKLDVLDGLDEIKVCVAYELDGERIDEFPASLEDLARCEPVYEELPGWKEDISGIRSFEDLP 389

                       410       420       430
                ....*....|....*....|....*....|....
gi 6324109  398 ENAKKYLKYIEDFVGVPVEWVGTGPARESMLHKE 431
Cdd:COG0104 390 ENARAYVERIEELLGVPISIVSVGPDREQTIVRR 423
PTZ00350 PTZ00350
adenylosuccinate synthetase; Provisional
 1-430 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 240376  Cd Length: 436  Bit Score: 634.37  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109     1 MVNVVLGSQWGDEGKGKLVDLLVGKYDIVARCAGGNNAGHTIVVDGVKYDFHMLPSGLVNPNCQNLLGNGVVIHVPSFFK 80
Cdd:PTZ00350  13 KVVVILGAQWGDEGKGKLVDILSEKADIVARFNGGANAGHTIVVDGKKYALHLLPCGILYPNCINVLGNGVVIHLPSLLE 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    81 ELETLEAKGlKNARSRLFVSSRAHLVFDFHQVTDKLRELElsgRSKDGKNIGTTGKGIGPTYSTKASRSGLRVHHLVNdq 160
Cdd:PTZ00350  93 EIEQLTKKG-INLLGRLYISDRAHLVFDLHQAIDGIQESE---KGKGGTQIGTTKRGIGPCYSTKASRTGLRVGDLLN-- 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   161 pgaWEEFVARYKRLLETRRQRYGDFEYDFEAKLAEYKKLREQLKPFVVDSVVFMHNAIEAKKKILVEGANALMLDIDFGT 240
Cdd:PTZ00350 167 ---FETFEKKYRKLVEKLQEQYNIEEYDAEEELERYKGYAEKLKDMIVDTVYFMNKAIKEGKRVLVEGANATMLDIDFGT 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   241 YPYVTSSNTGIGGVLTGLGIPPRTIDEIYGVVKAYTTRVGEGPFPTEQLNENGEKLQTIGAEFGVTTGRKRRCGWLDLVV 320
Cdd:PTZ00350 244 YPYVTSSNTTVGGVCTGLGIPPNAIILVIGVVKAYTTRVGEGPFPTELFDENGDYLRKKGHEYGTTTGRPRRCGWLDIPA 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   321 LKYSTLINGYTSLNITKLDVLDTFKEIPVGISYSIQGKKLDL--FPEDLNILGKVEVEYKVLPGWDQDITKITKYEDLPE 398
Cdd:PTZ00350 324 LRYVQMINGFDSINLTKLDVLSGLKEIKICVNYKNKGTGLEIgrYPSSIEELEEYEPVYETMPGWKTDISKCKTFEELPE 403

                        410       420       430
                 ....*....|....*....|....*....|..
gi 6324109   399 NAKKYLKYIEDFVGVPVEWVGTGPARESMLHK 430
Cdd:PTZ00350 404 NAQKYVLFIEELLGVPIVWIGVGPNRENMIVK 435
AdSS cd03108
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ...
 1-429 0e+00

adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.


Pssm-ID: 349762  Cd Length: 316  Bit Score: 524.76  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    1 MVNVVLGSQWGDEGKGKLVDLLVGKYDIVARCAGGNNAGHTIVVDGVKYDFHMLPSGLVNPNCQNLLGNGVVIHVPSFFK 80
Cdd:cd03108   1 KVTVVVGAQWGDEGKGKIVDYLAEKADIVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNATCVIGNGVVIDPPALFE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   81 ELETLEAKGLkNARSRLFVSSRAHLVFDFHQVTDKLRELELSGrskdgKNIGTTGKGIGPTYSTKASRSGLRVHHlvndq 160
Cdd:cd03108  81 EIEELEKKGI-DVKGRLLISDRAHLVFPYHQELDGLEEKERGG-----KKIGTTKRGIGPAYADKAARTGIRVGD----- 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109  161 pgaweefvarykrlletrrqrygdfeydfeaklaeykklreqlkPFVVDSVVFMHNAIEAKKKILVEGANALMLDIDFGT 240
Cdd:cd03108 150 --------------------------------------------PYVVDTVELLNEALKAGKKVLFEGAQGTLLDIDFGT 185

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109  241 YPYVTSSNTGIGGVLTGLGIPPRTIDEIYGVVKAYTTRVGEGPFPTEQLNENGEKLQTIGAEFGVTTGRKRRCGWLDLVV 320
Cdd:cd03108 186 YPYVTSSNTTAGGVCTGLGIPPRRVDRVIGVVKAYTTRVGSGPFPTELFDEEGEKLRELGHEYGTTTGRPRRCGWLDLVA 265

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109  321 LKYSTLINGYTSLNITKLDVldtfkeipvgisysiqgkkldlfpedlnilgkveveykvlpgwdqditkitkyedlpeNA 400
Cdd:cd03108 266 LRYAVRINGLTELALTKLDV----------------------------------------------------------NA 287

                       410       420
                ....*....|....*....|....*....
gi 6324109  401 KKYLKYIEDFVGVPVEWVGTGPARESMLH 429
Cdd:cd03108 288 QKYIERIEELLGVPITYISVGPDREQTII 316
amino_Aden_PurZ NF038379
succino-amino-deoxyadenylate synthase PurZ;
2-281 2.38e-26

succino-amino-deoxyadenylate synthase PurZ;


Pssm-ID: 468496  Cd Length: 292  Bit Score: 107.46  E-value: 2.38e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109     2 VNVVLGSQWGDEGKGKLVDLLV--GKYDIVARcAGGNNAGHTIVVD-GVKYDFHMLPSGLVNPNC-QNLLGNGVVIHVPS 77
Cdd:NF038379   1 VDVVVDGQFGSTGKGLIAGYLAerAAPDVVVR-AAGPNAGHTYIDDeGRKFVHRMLPNGIVSPPLkQVLIGPGSEIDLEV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    78 FFKELETLEAKGLKnARSRLFVSSRAHLVfdfhqVTDKLRELELSGRSKdgknIGTTGKGIGptystkASRsglrvhhlv 157
Cdd:NF038379  80 LREEIEELEDAGHD-VGKRLLIHEQATVI-----ELHKHVEEEAGPMTK----IGSTKKGIG------AAR--------- 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   158 ndqpgaweefVARYKRLLETRRQRYGDFEydfeaKLAEYKKLREQLKPFVVDSVvfMHNAIEAKKKILVEGANALMLDID 237
Cdd:NF038379 135 ----------AAKIRRNPSTLGDAEGDFG-----EGAVRDQPWEIAERVVDNAL--YDFALQAAERIQIEGTQGYSLGLH 197

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 6324109   238 FGTYPYVTSSNTGIGGVLTGLGIPPRTIDE--IYGVVKAYTTRVGE 281
Cdd:NF038379 198 AGFYPYCTSRDCTPADFLADAGIPLPNVDAfkVVGTARTYPIRVAG 243
 
Name Accession Description Interval E-value
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
4-428 0e+00

Adenylosuccinate synthetase;


Pssm-ID: 459912  Cd Length: 417  Bit Score: 729.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109      4 VVLGSQWGDEGKGKLVDLLVGKYDIVARCAGGNNAGHTIVVDGVKYDFHMLPSGLVNPNCQNLLGNGVVIHVPSFFKELE 83
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAEDADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109     84 TLEAKGLKnARSRLFVSSRAHLVFDFHQVTDKLRElelsgRSKDGKNIGTTGKGIGPTYSTKASRSGLRVHHLVNdqpga 163
Cdd:pfam00709  81 ELEERGID-VPDRLFISDRAHLILPYHKALDGLRE-----EARGKKKIGTTGRGIGPAYSDKAARRGIRVGDLLD----- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    164 WEEFVARYKRLLETRRQRYGDF---EYDFEAKLAEYKKLREQLKPFVVDSVVFMHNAIEAKKKILVEGANALMLDIDFGT 240
Cdd:pfam00709 150 PEVFREKLEALLELKNKLLEKLygePLDVEEELEELLEYAERLKPYVVDTSYFLNKALKEGKKILFEGAQGTLLDIDHGT 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    241 YPYVTSSNTGIGGVLTGLGIPPRTIDEIYGVVKAYTTRVGEGPFPTEQLNENGEKLQTIGAEFGVTTGRKRRCGWLDLVV 320
Cdd:pfam00709 230 YPYVTSSNTTAGGACTGLGIGPTKIDEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVA 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    321 LKYSTLINGYTSLNITKLDVLDTFKEIPVGISYSIQGKKLDLFPEDLNILGKVEVEYKVLPGWDQDITKITKYEDLPENA 400
Cdd:pfam00709 310 LRYAVRINGVTGLALTKLDVLDGLDEIKVCVAYELDGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENA 389

                         410       420
                  ....*....|....*....|....*...
gi 6324109    401 KKYLKYIEDFVGVPVEWVGTGPARESML 428
Cdd:pfam00709 390 RKYVEFIEELLGVPIKIISVGPDREQTI 417
Adenylsucc_synt smart00788
Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine ...
 2-429 0e+00

Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine biosynthesis, by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. Adenylosuccinate synthetase has been characterized from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present - one involved in purine biosynthesis and the other in the purine nucleotide cycle. The crystal structure of adenylosuccinate synthetase from E. coli reveals that the dominant structural element of each monomer of the homodimer is a central beta-sheet of 10 strands. The first nine strands of the sheet are mutually parallel with right-handed crossover connections between the strands. The 10th strand is antiparallel with respect to the first nine strands. In addition, the enzyme has two antiparallel beta-sheets, comprised of two strands and three strands each, 11 alpha-helices and two short 3/10-helices. Further, it has been suggested that the similarities in the GTP-binding domains of the synthetase and the p21ras protein are an example of convergent evolution of two distinct families of GTP-binding proteins. Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known structures from E. coli reveals that the overall fold is very similar to that of the E. coli protein.


Pssm-ID: 197875  Cd Length: 417  Bit Score: 678.82  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109       2 VNVVLGSQWGDEGKGKLVDLLVGKYDIVARCAGGNNAGHTIVVDGVKYDFHMLPSGLVNPNCQNLLGNGVVIHVPSFFKE 81
Cdd:smart00788   1 VVVVVGAQWGDEGKGKIVDYLAEKADVVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNKKNVIGNGVVIDPEALFKE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109      82 LETLEAKGLkNARSRLFVSSRAHLVFDFHQVTDKLRElelsgrskdGKNIGTTGKGIGPTYSTKASRSGLRVHHLVNDqp 161
Cdd:smart00788  81 IEELEAKGV-DVKDRLFISDRAHLILPYHIALDKARE---------KARIGTTGRGIGPAYEDKVARRGIRVGDLFDE-- 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109     162 gawEEFVARYKRLLETRRQRYGDF----EYDFEAKLAEYKKLREQLKPFVVDSVVFMHNAIEAKKKILVEGANALMLDID 237
Cdd:smart00788 149 ---EVLREKLEELLDYKNFLLKKLygaePVDVEEILEELLEYAERLRPYVTDVSELLNEALKAGKKVLFEGAQGTLLDID 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109     238 FGTYPYVTSSNTGIGGVLTGLGIPPRTIDEIYGVVKAYTTRVGEGPFPTEQLNENGEKLQTIGAEFGVTTGRKRRCGWLD 317
Cdd:smart00788 226 HGTYPYVTSSNTTAGGAATGAGIGPTRIDRVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGTTTGRPRRCGWFD 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109     318 LVVLKYSTLINGYTSLNITKLDVLDTFKEIPVGISYSIQGKKLDLFPEDLNILGKVEVEYKVLPGWDQDITKITKYEDLP 397
Cdd:smart00788 306 AVLLRYAVRINGITGLALTKLDVLDGLDEIKVCVAYKLDGKIIDYFPADLEDLERCEPIYEELPGWKEDTTGVRSYEDLP 385

                          410       420       430
                   ....*....|....*....|....*....|..
gi 6324109     398 ENAKKYLKYIEDFVGVPVEWVGTGPARESMLH 429
Cdd:smart00788 386 ENAKKYIERIEELVGVPVSIISTGPDREQTIV 417
purA TIGR00184
adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, ...
 4-433 0e+00

adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272949  Cd Length: 425  Bit Score: 677.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109      4 VVLGSQWGDEGKGKLVDLLVGKYDIVARCAGGNNAGHTIVVDGVKYDFHMLPSGLVNPNCQNLLGNGVVIHVPSFFKELE 83
Cdd:TIGR00184   1 VVVGGQWGDEGKGKIVDLLADKPDIVARYQGGHNAGHTIVIDGVKYGLHLIPSGFLYPDAKLLIGNGVVVDPEVLLKEME 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109     84 TLEaKGLKNARSRLFVSSRAHLVFDFHQVTDKLRElelsgRSKDGKNIGTTGKGIGPTYSTKASRSGLRVHHLVNDQPgA 163
Cdd:TIGR00184  81 YLE-KRGISVRDRLFVSYRCHLILPYHKKLDKARE-----KSKLAKKIGTTGKGIGPAYEDKVARSGLRVGDLLDDEA-F 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    164 WEEFVARYKRLLETRRQRYGDFEYDFEAKLAEYKKLREQLKPFVVDSVVFMHNAIEAKKKILVEGANALMLDIDFGTYPY 243
Cdd:TIGR00184 154 AEKAKNILEYLNEQLVKYYKDEGVDYEKKLDEYMKYAEELKPFVVDVSVELNEALDEGEKVLFEGAQGTMLDIDYGTYPY 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    244 VTSSNTGIGGVLTGLGIPPRTIDEIYGVVKAYTTRVGEGPFPTEQLNENGEKLQTIGAEFGVTTGRKRRCGWLDLVVLKY 323
Cdd:TIGR00184 234 VTSSNTTAGGVATGVGIGPTKVDEVIGVFKAYTTRVGAGPFPTELSDEEGEKLGTKGAEFGTTTGRRRRCGWFDLVAARY 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    324 STLINGYTSLNITKLDVLDTFKEIPVGISYSIQGKKLDLFPEDLNILGKVEVEYKVLPGWDQDITKITKYEDLPENAKKY 403
Cdd:TIGR00184 314 ACRLNGATQLALTKLDVLDGIDEIKVCVAYRMKGEILELFPLDLKDLKGVEPIYETLPGWDKECTGVTEYSDLPENAKKY 393

                         410       420       430
                  ....*....|....*....|....*....|..
gi 6324109    404 LKYIEDFVGVPVEWVGTGPARESM--LHKEIK 433
Cdd:TIGR00184 394 IERIEELTGVPVTIISTGPEREQTidLRKELL 425
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
 2-431 0e+00

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439874  Cd Length: 423  Bit Score: 635.51  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    2 VNVVLGSQWGDEGKGKLVDLLVGKYDIVARCAGGNNAGHTIVVDGVKYDFHMLPSGLVNPNCQNLLGNGVVIHVPSFFKE 81
Cdd:COG0104   1 NVVVVGAQWGDEGKGKIVDLLAERADVVVRFQGGNNAGHTVVVGGKKFKLHLIPSGILRPGKTCVIGNGVVLDPEALLEE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   82 LETLEAKGLkNARSRLFVSSRAHLVFDFHQVTDKLRElelsgRSKDGKNIGTTGKGIGPTYSTKASRSGLRVHHLVNDqp 161
Cdd:COG0104  81 IDGLEARGV-DVRSRLRISERAHLILPYHRALDKARE-----EARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLLDP-- 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109  162 gawEEFVARYKRLLE----TRRQRYGDFEYDFEAKLAEYKKLREQLKPFVVDSVVFMHNAIEAKKKILVEGANALMLDID 237
Cdd:COG0104 153 ---EVLREKLEELLEyknfLLEKLYGAEPLDFEELLEEYLEYAERLKPYVADTSELLNEALKAGKKVLFEGAQGTLLDID 229

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109  238 FGTYPYVTSSNTGIGGVLTGLGIPPRTIDEIYGVVKAYTTRVGEGPFPTEQLNENGEKLQTIGAEFGVTTGRKRRCGWLD 317
Cdd:COG0104 230 HGTYPYVTSSNTTAGGACTGSGVGPTKIDRVIGVVKAYTTRVGEGPFPTELFDETGERLRERGHEFGTTTGRPRRCGWLD 309

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109  318 LVVLKYSTLINGYTSLNITKLDVLDTFKEIPVGISYSIQGKKLDLFPEDLNILGKVEVEYKVLPGWDQDITKITKYEDLP 397
Cdd:COG0104 310 AVALRYAVRINGLTGLALTKLDVLDGLDEIKVCVAYELDGERIDEFPASLEDLARCEPVYEELPGWKEDISGIRSFEDLP 389

                       410       420       430
                ....*....|....*....|....*....|....
gi 6324109  398 ENAKKYLKYIEDFVGVPVEWVGTGPARESMLHKE 431
Cdd:COG0104 390 ENARAYVERIEELLGVPISIVSVGPDREQTIVRR 423
PTZ00350 PTZ00350
adenylosuccinate synthetase; Provisional
 1-430 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 240376  Cd Length: 436  Bit Score: 634.37  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109     1 MVNVVLGSQWGDEGKGKLVDLLVGKYDIVARCAGGNNAGHTIVVDGVKYDFHMLPSGLVNPNCQNLLGNGVVIHVPSFFK 80
Cdd:PTZ00350  13 KVVVILGAQWGDEGKGKLVDILSEKADIVARFNGGANAGHTIVVDGKKYALHLLPCGILYPNCINVLGNGVVIHLPSLLE 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    81 ELETLEAKGlKNARSRLFVSSRAHLVFDFHQVTDKLRELElsgRSKDGKNIGTTGKGIGPTYSTKASRSGLRVHHLVNdq 160
Cdd:PTZ00350  93 EIEQLTKKG-INLLGRLYISDRAHLVFDLHQAIDGIQESE---KGKGGTQIGTTKRGIGPCYSTKASRTGLRVGDLLN-- 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   161 pgaWEEFVARYKRLLETRRQRYGDFEYDFEAKLAEYKKLREQLKPFVVDSVVFMHNAIEAKKKILVEGANALMLDIDFGT 240
Cdd:PTZ00350 167 ---FETFEKKYRKLVEKLQEQYNIEEYDAEEELERYKGYAEKLKDMIVDTVYFMNKAIKEGKRVLVEGANATMLDIDFGT 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   241 YPYVTSSNTGIGGVLTGLGIPPRTIDEIYGVVKAYTTRVGEGPFPTEQLNENGEKLQTIGAEFGVTTGRKRRCGWLDLVV 320
Cdd:PTZ00350 244 YPYVTSSNTTVGGVCTGLGIPPNAIILVIGVVKAYTTRVGEGPFPTELFDENGDYLRKKGHEYGTTTGRPRRCGWLDIPA 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   321 LKYSTLINGYTSLNITKLDVLDTFKEIPVGISYSIQGKKLDL--FPEDLNILGKVEVEYKVLPGWDQDITKITKYEDLPE 398
Cdd:PTZ00350 324 LRYVQMINGFDSINLTKLDVLSGLKEIKICVNYKNKGTGLEIgrYPSSIEELEEYEPVYETMPGWKTDISKCKTFEELPE 403

                        410       420       430
                 ....*....|....*....|....*....|..
gi 6324109   399 NAKKYLKYIEDFVGVPVEWVGTGPARESMLHK 430
Cdd:PTZ00350 404 NAQKYVLFIEELLGVPIVWIGVGPNRENMIVK 435
PLN02513 PLN02513
adenylosuccinate synthase
 2-430 0e+00

adenylosuccinate synthase


Pssm-ID: 178129  Cd Length: 427  Bit Score: 611.65  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109     2 VNVVLGSQWGDEGKGKLVDLLVGKYDIVARCAGGNNAGHTIV-VDGVKYDFHMLPSGLVNPNCQNLLGNGVVIHVPSFFK 80
Cdd:PLN02513   4 VSAVLGTQWGDEGKGKLVDILAQHFDIVARCQGGANAGHTIYnDEGKKFALHLVPSGILNEKTTCVIGNGVVVHLPGLFE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    81 ELETLEAKGLkNARSRLFVSSRAHLVFDFHQVTDKLRELELSGrSKdgknIGTTGKGIGPTYSTKASRSGLRVHHLVNdq 160
Cdd:PLN02513  84 EIDGLESNGV-SCEGRLLVSDRAHLLFDFHQEVDGLREAELAG-SK----IGTTKRGIGPAYSSKATRNGLRVGDLRH-- 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   161 pgaWEEFVARYKRLLETRRQRYGDFEYD---FEAKLAEYKKLREQLKPFVVDSVVFMHNAIEAKKKILVEGANALMLDID 237
Cdd:PLN02513 156 ---MDTFAEKLRELLADAAARFEGFEYDasmVEEEVEAYKKFAERLEPFITDTVHYLNEAIQAGKKILVEGAQATMLDID 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   238 FGTYPYVTSSNTGIGGVLTGLGIPPRTIDEIYGVVKAYTTRVGEGPFPTEQLNENGEKLQTIGAEFGVTTGRKRRCGWLD 317
Cdd:PLN02513 233 FGTYPFVTSSNPSAGGICTGLGIAPRKLGDIIGVVKAYTTRVGSGPFPTELFGELGDLLREAGQEFGTTTGRPRRCGWLD 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   318 LVVLKYSTLINGYTSLNITKLDVLDTFKEIPVGISYS-IQGKKLDLFPEDLNILGKVEVEYKVLPGWDQDITKITKYEDL 396
Cdd:PLN02513 313 IVALKYSCQINGFTSLNLTKLDVLSGLPEIKIGVAYKtPDGKVVKSFPADLDTLEQVEVVYEVLPGWQEDISSVRNYDDL 392

                        410       420       430
                 ....*....|....*....|....*....|....
gi 6324109   397 PENAKKYLKYIEDFVGVPVEWVGTGPARESMLHK 430
Cdd:PLN02513 393 PAAAQAYVERIEELVGVPVHYIGVGPGRDALIVK 426
PRK01117 PRK01117
adenylosuccinate synthetase; Provisional
 4-425 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 234904  Cd Length: 430  Bit Score: 607.04  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109     4 VVLGSQWGDEGKGKLVDLLVGKYDIVARCAGGNNAGHTIVVDGVKYDFHMLPSGLVNPNCQNLLGNGVVIHVPSFFKELE 83
Cdd:PRK01117   5 VVVGTQWGDEGKGKIVDLLSERADVVVRFQGGHNAGHTLVIDGKKYKLHLIPSGILRPGKTCVIGNGVVLDPEALLKEID 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    84 TLEAKGLkNARSRLFVSSRAHLVFDFHQVTDKLRElelsgRSKDGKNIGTTGKGIGPTYSTKASRSGLRVHHLVNDqpga 163
Cdd:PRK01117  85 ELEARGV-DVRERLRISERAHLILPYHRALDKARE-----KARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLLDP---- 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   164 wEEFVARYKRLLE----TRRQRYGDFEYDFEAKLAEYKKLREQLKPFVVDSVVFMHNAIEAKKKILVEGANALMLDIDFG 239
Cdd:PRK01117 155 -ETFAEKLEENLEyknfLLTKYYGAEAVDFEEILDEYLEYAERLKPYVTDTSLLLNDALKAGKRVLFEGAQGTLLDIDHG 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   240 TYPYVTSSNTGIGGVLTGLGIPPRTIDEIYGVVKAYTTRVGEGPFPTEQLNENGEKLQTIGAEFGVTTGRKRRCGWLDLV 319
Cdd:PRK01117 234 TYPFVTSSNTTAGGAATGSGVGPTKIDYVLGIAKAYTTRVGSGPFPTELFDEVGEHLRERGHEFGTTTGRPRRCGWFDAV 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   320 VLKYSTLINGYTSLNITKLDVLDTFKEIPVGISYSIQGKKLDLFPEDLNILGKVEVEYKVLPGWDQDITKITKYEDLPEN 399
Cdd:PRK01117 314 ALRYAVRVNGLTGLALTKLDVLDGLEEIKICVAYELDGKRIDYFPASLEDLARCEPIYEELPGWSESTTGVRSFDDLPEN 393

                        410       420
                 ....*....|....*....|....*.
gi 6324109   400 AKKYLKYIEDFVGVPVEWVGTGPARE 425
Cdd:PRK01117 394 ARKYIKRIEELTGVPISIISTGPDRD 419
AdSS cd03108
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ...
 1-429 0e+00

adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.


Pssm-ID: 349762  Cd Length: 316  Bit Score: 524.76  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    1 MVNVVLGSQWGDEGKGKLVDLLVGKYDIVARCAGGNNAGHTIVVDGVKYDFHMLPSGLVNPNCQNLLGNGVVIHVPSFFK 80
Cdd:cd03108   1 KVTVVVGAQWGDEGKGKIVDYLAEKADIVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNATCVIGNGVVIDPPALFE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   81 ELETLEAKGLkNARSRLFVSSRAHLVFDFHQVTDKLRELELSGrskdgKNIGTTGKGIGPTYSTKASRSGLRVHHlvndq 160
Cdd:cd03108  81 EIEELEKKGI-DVKGRLLISDRAHLVFPYHQELDGLEEKERGG-----KKIGTTKRGIGPAYADKAARTGIRVGD----- 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109  161 pgaweefvarykrlletrrqrygdfeydfeaklaeykklreqlkPFVVDSVVFMHNAIEAKKKILVEGANALMLDIDFGT 240
Cdd:cd03108 150 --------------------------------------------PYVVDTVELLNEALKAGKKVLFEGAQGTLLDIDFGT 185

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109  241 YPYVTSSNTGIGGVLTGLGIPPRTIDEIYGVVKAYTTRVGEGPFPTEQLNENGEKLQTIGAEFGVTTGRKRRCGWLDLVV 320
Cdd:cd03108 186 YPYVTSSNTTAGGVCTGLGIPPRRVDRVIGVVKAYTTRVGSGPFPTELFDEEGEKLRELGHEYGTTTGRPRRCGWLDLVA 265

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109  321 LKYSTLINGYTSLNITKLDVldtfkeipvgisysiqgkkldlfpedlnilgkveveykvlpgwdqditkitkyedlpeNA 400
Cdd:cd03108 266 LRYAVRINGLTELALTKLDV----------------------------------------------------------NA 287

                       410       420
                ....*....|....*....|....*....
gi 6324109  401 KKYLKYIEDFVGVPVEWVGTGPARESMLH 429
Cdd:cd03108 288 QKYIERIEELLGVPITYISVGPDREQTII 316
PRK13787 PRK13787
adenylosuccinate synthetase; Provisional
 3-425 1.18e-125

adenylosuccinate synthetase; Provisional


Pssm-ID: 172324  Cd Length: 423  Bit Score: 370.44  E-value: 1.18e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109     3 NVVLGSQWGDEGKGKLVDLLVGKYDIVARCAGGNNAGHTIVVDGVKYDFHMLPSGLVNPNCQNLLGNGVVIHVPSFFKEL 82
Cdd:PRK13787   4 SLVVGTQWGDEGKAKVIDFLSKDTDIIVRYQGGANAGHTVVVHGKKYVFHLVPSGVIYDQTICVIGNGVVLDPLFFIEEC 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    83 ETLEAKGLKnARSRLFVSSRAHLVFDFHQVTDKLRELELSGRSKdgknIGTTGKGIGPTYSTKASRSGLRVHHLVNDQpg 162
Cdd:PRK13787  84 DRLQKEGFP-VKDKLLLSDACHLLFPYHSQIDSARETTSSQEHK----IGTTKKGIGICYADKMMRTGLRVGDLLDKS-- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   163 aweeFVARYKRLLETRRQRYGDFeYDFEAklAEYKKLREQLKPF-------VVDSVVFMHNAIEAKKKILVEGANALMLD 235
Cdd:PRK13787 157 ----YKRRLKHLVDEKNRELDKL-YGMPP--VSYNDINDGLKFFlskvgknIINTAYYLDTELKKGKRVLLEGAQGTGLD 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   236 IDFGTYPYVTSSNTGIGGVLTGLGIPPRTIDEIYGVVKAYTTRVGEGPFPTEQLNENGEKLQTIGAEFGVTTGRKRRCGW 315
Cdd:PRK13787 230 VDFGTYPYVTSSNPTTGGALIGTGISFQHLKHVIGITKAYTTRVGEGPFPTELLGEAGEVLRQKGGEFGATTGRPRRCGW 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   316 LDLVVLKYSTLINGYTSLNITKLDVLDTFKEIPVGISYSIQGKKLDLFPEdlNILGKVEVEYKVLPGWDQDITKITKYED 395
Cdd:PRK13787 310 FDVEMLKHSVRINGITSIALTKIDILSDYDTIPVAVGYKLNGKTLDCFPS--QGLEKVEPLYEEFPGWKDDISGINEFQK 387

                        410       420       430
                 ....*....|....*....|....*....|
gi 6324109   396 LPENAKKYLKYIEDFVGVPVEWVGTGPARE 425
Cdd:PRK13787 388 LPEKCKNYISALEKWIGVKINLVSTGPDRK 417
PRK13788 PRK13788
adenylosuccinate synthetase; Provisional
 5-425 1.73e-125

adenylosuccinate synthetase; Provisional


Pssm-ID: 184326 [Multi-domain]  Cd Length: 404  Bit Score: 369.52  E-value: 1.73e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109     5 VLGSQWGDEGKGKLVDLLVGKYDIVARCAGGNNAGHTIVVDGVKYDFHMLPSGLVNPNCQNLLGNGVVIHVPSFFKELET 84
Cdd:PRK13788   6 IIGAQWGDEGKGKVVDALAPEADFVVRYQGGANAGHTVVAKGKTFKLNLLPSGVLHPHATSVLGDGMVIDPFRFAEEREN 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    85 LEAKGLKnarSRLFVSSRAHLVFDFHQVTDklrelelsgrskDGKN-IGTTGKGIGPTYSTKASRSGLRVHHLVNDqpGA 163
Cdd:PRK13788  86 LRAGGLN---PKLLISERAHLVLPHHKYVD------------GRKNfVGTTGRGIGPAYSDRARRVGIRFGDLLDE--AV 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   164 WEEfvaRYKRLLETRRQRYGDFEYD-FEAKLAEYKKLREQLKPFVVDSVVFMHNAIEAKKKILVEGANALMLDIDFGTYP 242
Cdd:PRK13788 149 LRE---RVERLLEAKPNSTREAGWDtVEKALADLAPMREILLPFIADTGSLLREAIREGKRVLFEGAQATLLDLNYGTYP 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   243 YVTSSNTGIGGVLTGLGIPPRTIDEIYGVVKAYTTRVGEGPFPTEQLNENGEKLQTIGA----EFGVTTGRKRRCGWLDL 318
Cdd:PRK13788 226 YVTSSHPTVGGILVGAGVNHKAINKVYGVAKAFTTRVGHGPFPTEVFGEMAIRLRGKGGnpwdEFGTTTGRARRVGWLDL 305

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   319 VVLKYSTLINGYTSLNITKLDVLDTFKEIPVGISYSIQGKkldlfpedlnilgkveVEYKVLPGWdQDITKITKYEDLPE 398
Cdd:PRK13788 306 VLLKYACEVNGFDGLVLTKLDVLSGLEKVKVCVEYDDDGQ----------------PVYKELPGW-GDLDGVKSREALPK 368

                        410       420
                 ....*....|....*....|....*..
gi 6324109   399 NAKKYLKYIEDFVGVPVEWVGTGPARE 425
Cdd:PRK13788 369 EAQAYLELIEETTGVPVVMFSTSPRRE 395
PRK13786 PRK13786
adenylosuccinate synthetase; Provisional
 1-431 5.11e-121

adenylosuccinate synthetase; Provisional


Pssm-ID: 184325  Cd Length: 424  Bit Score: 358.73  E-value: 5.11e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109     1 MVNVVLGSQWGDEGKGKLVDLLVGKYDIVARCAGGNNAGHTIVVDGVKYDFHMLPSGLVnPNCQNLLGNGVVIHVPSFFK 80
Cdd:PRK13786   1 MFTIITGAQFGDEGKGKIVDLLAKDYDIVARFQGGDNAGHTVKVGDEVYKLHLIPSGFL-LDARVLIGPGVVLNPEVLAE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    81 ELETLEAKGLKNARSRLFVSSRAHLVFDFHQVTDKLRElelSGRSKdgkNIGTTGKGIGPTYSTKASRSGLRVHHLVNDq 160
Cdd:PRK13786  80 EIDMLEKHGVKVDAEKLGIDAKTSIIMPYHIELDGLRE---SARTE---KIGTTKRGIGFAYIDKIARDEVRMSDLVDK- 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   161 pgawEEFVARYKRLLETRRQRYGDFEYD-----FEAKLAEYKKLREQLKPFVVDSVVFMHNAIEAKKKILVEGANALMLD 235
Cdd:PRK13786 153 ----ERLMRRLEELAPQKEKEIKELGGDpsivrDEALIDKYLELGRQLAPYITDVSYEINKALDEGKSVLAEGAQGTHLD 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   236 IDFGTYPYVTSSNTGIGGVLTGLGIPPRTIDEIYGVVKAYTTRVGEGPFPTEQLNENGEKLQTIGAEFGVTTGRKRRCGW 315
Cdd:PRK13786 229 VIHGTQKFVTSSSTIAGSACANLGVGPTRVDNVLGIVKAYITRVGEGPLPTELKDEAGEHLQDVGGEFGTTTGRPRRCGW 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   316 LDLVVLKYSTLINGYTSLNITKLDVLDTFKEIPVGISYSIQGKKLDLFPEDLNILGKVEVEYKVLPGWDQDITKITKYED 395
Cdd:PRK13786 309 FDLPLLKKAIYLNGYTEIALTKLDVLTGLDPIKICVGYELDGEILDYPPELTSDLARCVPVYEELEGWSTDLTEVKAYED 388

                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 6324109   396 LPENAKKYLKYIEDFVGVPVEWVGTGPARESMLHKE 431
Cdd:PRK13786 389 LPENARNYVERLEELMGVPIKYISVGPGREQTFKKE 424
PRK13783 PRK13783
adenylosuccinate synthetase; Provisional
 1-430 5.73e-119

adenylosuccinate synthetase; Provisional


Pssm-ID: 237505  Cd Length: 404  Bit Score: 352.87  E-value: 5.73e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109     1 MVNVVLGSQWGDEGKGKLVDLLVGKYDIVARCAGGNNAGHTIVVDGVKYDFHMLPSGLVNPNCQNLLGNGVVIHVPSFFK 80
Cdd:PRK13783   1 MKRVIVGLQWGDEGKGKVVTYLSRYYDIVVRYSGGANAGHTVNYGDFKVVHHLLPSADFKKNVGAAIGNGVVLDLEVLVE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    81 ELETLEAKGlKNARSRLFVSSRAHLVFDFHQVTDKLRElelsgrSKDGKNIGTTGKGIGPTYSTKASRSGLRVHHLVNDQ 160
Cdd:PRK13783  81 ELEELKEKF-PDYSGRIFISELAHVVLPVHKELDEIIE------SVRKNAIGTTKRGIGPAYADKVMRVGVRLADLFDEE 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   161 PGA--WEEFVARYKRLLETRRQRYGDFEYDFEAKlaeykklrEQLKPFVVDSVVfMHNAIEaKKKILVEGANALMLDIDF 238
Cdd:PRK13783 154 KLRefLEKILSLYKKLYGIEFDVEKMMEDLLTFY--------EKIKDLVVSPVE-IKRILE-EKSVLFEGTQGVLLDLDV 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   239 GTYPYVTSSNTGIGGVLTGLGIPPRtIDEIYGVVKAYTTRVGEGPFPTEQLNENGEKLQTIGAEFGVTTGRKRRCGWLDL 318
Cdd:PRK13783 224 GTYPYVTSSNCSTTGVSAGMGFPVK-VDEVIGVFKAYTTRVGEGPFPTELFGEEGEKLRKAGHEYGATTGRPRRCGWLDL 302

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   319 VVLKYSTLINGYTSLNITKLDVLDTFKEIPVGISYSIQGKKLDLfPEDLNILGKVEVEYKVLPGWdqditkitkyEDLPE 398
Cdd:PRK13783 303 PLLRYAIEVSGVDSLVMTKADVLNGFEKIKVCVRYEIGGKEVRD-PSSLRDLEKAEPVYEEFDGW----------KSLED 371

                        410       420       430
                 ....*....|....*....|....*....|...
gi 6324109   399 -NAKKYLKYIEDFVGVPVEWVGTGPARESMLHK 430
Cdd:PRK13783 372 kNFLKFVDFIERETGRKIAYISTGPKIEEIVEV 404
PRK13785 PRK13785
adenylosuccinate synthetase; Provisional
 1-431 6.68e-108

adenylosuccinate synthetase; Provisional


Pssm-ID: 237506  Cd Length: 454  Bit Score: 326.33  E-value: 6.68e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109     1 MVNVVLGSQWGDEGKGKLVDLLVGKYDIVARCAGGNNAGHTIVVDGVKYDFHMLPSGLVNPNCqNLLGNGVVIHVPSFFK 80
Cdd:PRK13785   1 MTVTIVGSQLGDEGKGGVVDLYGDAADVVVRYQGGDNAGHTVVHGGEEYKLSLVPSGAVRGKI-GVLGNGCVVNPETLFD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    81 ELETLEAKGLK-NARsrlfVSSRAHLVFDFHQVTDKLRElelSGRSKDGKNIGTTGKGIGPTYSTKASRSGLRVHHLVNd 159
Cdd:PRK13785  80 EIDALRERGLDpDVR----VAERAHVILPYHRVLDGIEE---EAKSDSDLEVGTTGRGIGPTYEDKAGRRGVRVGDLLD- 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   160 qPGAWE---EFVARYKRLLEtrRQRYG------DFEYDFEAKLAEYKKLREQLKP--FVVDSVVFMHNAIEAKKKILVEG 228
Cdd:PRK13785 152 -PDVLRdrlEYVVPQKRALA--EDVYGldasetPEAFDVDALFEEYREYGERLAEedMTVNAGDFLAERIDDGDNVMLEG 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   229 ANALMLDIDFGTYPYVTSSNTGIGGVLTGLGIPPRTI--DEIYGVVKAYTTRVGEGPFPTE-----------QLNENGEK 295
Cdd:PRK13785 229 AQGTSIDIDHGNYPYVTSSNPTAGGAATGTGLGPTVVgqGEVVGIVKAYLSRVGSGPLPTElggvegdtpdeGGRPDEEE 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   296 LQTI----GAEFGVTTGRKRRCGWLDLVVLKYSTLINGYTSLNITKLDVLDTFKEIPVGISYSIQGKKLDLFPEDLNILG 371
Cdd:PRK13785 309 LATYireeGGEYGTVTGRPRRVGWLDMPMLRHAARASGFTGLAINHIDVLAGLDEVKVGHSYELDGEELLTMPATTERWA 388

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6324109   372 KVEVEYKVLPGWD-QDITKITK--YEDLPENAKKYLKYIEDFVGVPVEWVGTGPARESMLHKE 431
Cdd:PRK13785 389 RCEPNFRSFDGWPeVDWAAVAEegYDALPENARTYLEYVSDELDTPIYAVGVGPGREETVVLE 451
PRK13784 PRK13784
adenylosuccinate synthetase; Provisional
 4-431 5.28e-98

adenylosuccinate synthetase; Provisional


Pssm-ID: 172322  Cd Length: 428  Bit Score: 300.01  E-value: 5.28e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109     4 VVLGSQWGDEGKGKLVDLLVGKYDIVARCAGGNNAGHTIVVDGVKYDFHMLPSGLVNPNCQNLLGNGVVIHVPSFFKELE 83
Cdd:PRK13784   5 VIVGAQWGDEGKGKIADTLAEKADLVVRYQGGNNAGHTLVVNGKKTFLHLIPSGVLHQHTKCVIGHGVVLDPVALDEEIT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    84 TLEAKGLKNARSRLFVSSRAHLVFDFHQVTDKLRElelsgrSKDGKNIGTTGKGIGPTYSTKASRSGLRVHHLVNDqpga 163
Cdd:PRK13784  85 RLQAKGIAISAENLFVSESCTIITSYHKLLDAVRE------SNTSEKIGTTGKGIGPAYEDKVSRKGIKFKHLFDK---- 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   164 wEEFVARYKRLLETRRQRYGDF---EY-DFEAKLAEYKKLREQLKPFVVDSVVFMHNAIEAKKKILVEGANALMLDIDFG 239
Cdd:PRK13784 155 -DLLRSRLAISLAEKETLFRDLykvEYpTLEQEFDKLFALGQKLKQYAADTFSIIDQAIAAGKNVVYEGAQGVLLDVDYG 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   240 TYPYVTSSNTGIGGVLTGLGIPPRTIDEIYGVVKAYTTRVGEGPFPTEQLNENGEKLQTIGAEFGVTTGRKRRCGWLDLV 319
Cdd:PRK13784 234 TYPFVTSSNTSVAGVYSGATTAGHGLDHVIGITKAYTTRVGEGPFPTELFDDVGKFIQHKGGEIGVTTGRIRRCGWLDLP 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   320 VLKYSTLINGYTSLNITKLDVLDTFKEIPVGISYSIQGKKLDL-FPE-DLNILGKVEVEYKVLpGWDQDITKitkyEDLP 397
Cdd:PRK13784 314 LLKYSAKCSNLTSIALTKVDVLSDMDTLKVCIGYKYEGKEIYCaYPGiDLYKVEPILVEMEPF-SIDETVTK----DNMP 388

                        410       420       430
                 ....*....|....*....|....*....|....
gi 6324109   398 ENAKKYLKYIEDFVGVPVEWVGTGPARESMLHKE 431
Cdd:PRK13784 389 AALKTYLKTIENHVGIPISSLAYGPSREQILFFE 422
PRK04293 PRK04293
adenylosuccinate synthetase; Provisional
 1-422 1.95e-83

adenylosuccinate synthetase; Provisional


Pssm-ID: 179812  Cd Length: 333  Bit Score: 259.04  E-value: 1.95e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109     1 MVNVVLGSQWGDEGKGKLVDLL--VGKYDIVARCAGGNNAGHTIVVDGVKYDFHMLPSGLVNPNCQNLLGNGVVIHVPSF 78
Cdd:PRK04293   2 TCTIVVGGFFGDEGKGKIIAYLalKDKPSIIARGGVGPNAGHTVEYNGKKYGLRMIPSGFVNKDAKLAIGAGVLVDPEVL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    79 FKELETLeakglkNARSRLFVSSRAHLVFDFHQVTDKLRElELSgrskdgKNIGTTGKGIGPtystkasrsglrvhhlvn 158
Cdd:PRK04293  82 LKEVEEL------NVGGRVFVDYRCGIIEEKHVEEDRSDE-HLS------KKIGSTGTGCGP------------------ 130

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   159 dqpgaweefvARYKRLLetRRqrygdfeydfeAKLAeykKLREQLKPFVVDSVVFMHNAIEAKKKILVEGANALMLDIDF 238
Cdd:PRK04293 131 ----------ANADRVL--RR-----------LKLA---KDVEELEKYLTDVPEEVNEALDRGENVLIEGTQGFGLSLYY 184

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   239 GTYPYVTSSNTGIGGVLTGLGIPPRTIDEIYGVVKAYTTRVGEGPFPTEQLNENGEKLqtiG-AEFGVTTGRKRRCGWLD 317
Cdd:PRK04293 185 GTYPYVTSKDTTASGIASDVGVGPTKVDEVIVVFKSYPTRVGEGPFPTELSLEEAEKL---GlVEYGTVTGRRRRVGPFD 261

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   318 LVVLKYSTLINGYTSLNITKLDVLDTfkeipvgisysiqgkkldlfpedlnilgkveveykvlpgwdqDITKITKYEDLP 397
Cdd:PRK04293 262 FELARRAARINGATQIAITKLDKLDK------------------------------------------EAYGVTEYDKLP 299

                        410       420
                 ....*....|....*....|....*
gi 6324109   398 ENAKKYLKYIEDFVGVPVEWVGTGP 422
Cdd:PRK04293 300 PEAKKFIEEIEEELGVPVTLISTGP 324
amino_Aden_PurZ NF038379
succino-amino-deoxyadenylate synthase PurZ;
2-281 2.38e-26

succino-amino-deoxyadenylate synthase PurZ;


Pssm-ID: 468496  Cd Length: 292  Bit Score: 107.46  E-value: 2.38e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109     2 VNVVLGSQWGDEGKGKLVDLLV--GKYDIVARcAGGNNAGHTIVVD-GVKYDFHMLPSGLVNPNC-QNLLGNGVVIHVPS 77
Cdd:NF038379   1 VDVVVDGQFGSTGKGLIAGYLAerAAPDVVVR-AAGPNAGHTYIDDeGRKFVHRMLPNGIVSPPLkQVLIGPGSEIDLEV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    78 FFKELETLEAKGLKnARSRLFVSSRAHLVfdfhqVTDKLRELELSGRSKdgknIGTTGKGIGptystkASRsglrvhhlv 157
Cdd:NF038379  80 LREEIEELEDAGHD-VGKRLLIHEQATVI-----ELHKHVEEEAGPMTK----IGSTKKGIG------AAR--------- 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109   158 ndqpgaweefVARYKRLLETRRQRYGDFEydfeaKLAEYKKLREQLKPFVVDSVvfMHNAIEAKKKILVEGANALMLDID 237
Cdd:NF038379 135 ----------AAKIRRNPSTLGDAEGDFG-----EGAVRDQPWEIAERVVDNAL--YDFALQAAERIQIEGTQGYSLGLH 197

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 6324109   238 FGTYPYVTSSNTGIGGVLTGLGIPPRTIDE--IYGVVKAYTTRVGE 281
Cdd:NF038379 198 AGFYPYCTSRDCTPADFLADAGIPLPNVDAfkVVGTARTYPIRVAG 243
PTZ00351 PTZ00351
adenylosuccinate synthetase; Provisional
 2-177 3.53e-15

adenylosuccinate synthetase; Provisional


Pssm-ID: 173544  Cd Length: 710  Bit Score: 77.78  E-value: 3.53e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109     2 VNVVLGSQWGDEGKGKLVDlLVGKYDI---VARCAGGNNAGHTIVVD-GVKYDFHMLPSGLVNPNCQNLLGNGVVIHVPS 77
Cdd:PTZ00351 171 VIMVAGAFFGDEGKGKTVD-AVAHHPLctcIARVNSGENAGHTVYDKaGRKFVFNLAPSGLLLPGKRNYIGPECVMDPVS 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324109    78 FF-KELETLEAKGLkNARSRLFVSSRAhLVFDFHQVtdklreLELSGRSKDgkniGTTGKGIGPTYSTKASRSGLRVHHL 156
Cdd:PTZ00351 250 FMeKEIIQLIDAGI-DYRDRLFIGNVC-IVTPYHKL------LDLLGSAAN----SSTLKGMAPVHGSKVMKRGIRLDHI 317

                        170       180
                 ....*....|....*....|.
gi 6324109   157 VNDQpgawEEFVARYKRLLET 177
Cdd:PTZ00351 318 FNDD----ETLRKRLEKDMDT 334
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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