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Conserved domains on  [gi|6324291|ref|NP_014361|]
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isocitrate dehydrogenase (NAD(+)) IDH1 [Saccharomyces cerevisiae S288C]

Protein Classification

NAD-dependent isocitrate dehydrogenase( domain architecture ID 10015520)

NAD-dependent isocitrate dehydrogenase converts isocitrate to 2-oxoglutarate in an NAD-dependent manner

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 26-357 0e+00

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


:

Pssm-ID: 272942  Cd Length: 333  Bit Score: 582.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291     26 GGRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIK-QTDHK-EGVYEAVESLKRNKIGLKGLWHTPADQTGHGS 103
Cdd:TIGR00175   1 GGKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSpQTDGKtEIPDEAVESIKRNKVALKGPLETPIGKGGHRS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291    104 LNVALRKQLDIYANVALFKSLKGVKTRIPDIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKK 183
Cdd:TIGR00175  81 LNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYARK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291    184 YNRKSVTAVHKANIMKLGDGLFRNIITEIGqKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIG 263
Cdd:TIGR00175 161 NGRKKVTAVHKANIMKLADGLFLNVCREVA-KEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291    264 GPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISKAVHETIAEGKHTTRDIGGS 343
Cdd:TIGR00175 240 GPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGGT 319

                         330
                  ....*....|....
gi 6324291    344 SSTTDFTNEIINKL 357
Cdd:TIGR00175 320 ATTSDFTEAVIKRL 333
 
Name Accession Description Interval E-value
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 26-357 0e+00

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 582.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291     26 GGRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIK-QTDHK-EGVYEAVESLKRNKIGLKGLWHTPADQTGHGS 103
Cdd:TIGR00175   1 GGKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSpQTDGKtEIPDEAVESIKRNKVALKGPLETPIGKGGHRS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291    104 LNVALRKQLDIYANVALFKSLKGVKTRIPDIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKK 183
Cdd:TIGR00175  81 LNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYARK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291    184 YNRKSVTAVHKANIMKLGDGLFRNIITEIGqKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIG 263
Cdd:TIGR00175 161 NGRKKVTAVHKANIMKLADGLFLNVCREVA-KEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291    264 GPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISKAVHETIAEGKHTTRDIGGS 343
Cdd:TIGR00175 240 GPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGGT 319

                         330
                  ....*....|....
gi 6324291    344 SSTTDFTNEIINKL 357
Cdd:TIGR00175 320 ATTSDFTEAVIKRL 333
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 4-357 1.16e-125

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 365.34  E-value: 1.16e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291     4 RTIAKRTLATAAQAERT--LPKKYGGR-FTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIkQTDHKEGVYEAVES 80
Cdd:PLN00123   3 KRLLSNALGSKAQRRSVtyMPRPGDGApRAVTLIPGDGIGPLVTGAVEQVMEAMHAPVYFERYEV-HGDMKKVPEEVLES 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291    81 LKRNKIGLKGLWHTPADqTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPDIDLIVIRENTEGEFSGLEHESVPGVVE 160
Cdd:PLN00123  82 IRRNKVCLKGGLATPVG-GGVSSLNVQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYSGLEHEVVPGVVE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   161 SLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKeYPDIDVSSIIVDNASMQAVAKPHQ 240
Cdd:PLN00123 161 SLKVITKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKK-YPGIKYNEIIVDNCCMQLVSKPEQ 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   241 FDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRDYAVFEPGSRHVGL---DIKGQNVANPTAMILSSTLMLNHLGLNE 317
Cdd:PLN00123 240 FDVMVTPNLYGNLVANTAAGIAGGTGVMPGGNVGADHAVFEQGASAGNVgneKLVEQKKANPVALLLSSAMMLRHLQFPS 319

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 6324291   318 YATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKL 357
Cdd:PLN00123 320 FADRLETAVKRVIAEGKYRTKDLGGSSTTQEVVDAVIANL 359
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 28-357 9.95e-124

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 359.71  E-value: 9.95e-124
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   28 RFTVTLIPGDGVGKEITDSVRTIFEA----ENIPIDWETINI-KQTDHKEGVY---EAVESLKRNKIGLKGLWHTPADQT 99
Cdd:COG0473   1 TYKIAVLPGDGIGPEVVAAALKVLEAaaerFGLDFEFEEADIgGAAYDKTGTPlpdETLEALRKADAILLGAVGGPKWDD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291  100 GHG--SLNVALRKQLDIYANVALFKSLKGVKTR-----IPDIDLIVIRENTEGEFSGLEHESVPG----VVESLKVMTRP 168
Cdd:COG0473  81 GVRpeSGLLALRKELDLYANLRPAKLYPGLPSPlkpeiVEGIDLVIVRENTEGLYFGIGGRIGTGtgeeVAIDTRVYTRK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291  169 KTERIARFAFDFAKKyNRKSVTAVHKANIMKLGDGLFRNIITEIGqKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPS 248
Cdd:COG0473 161 GIERIARYAFELARK-RRKKVTSVDKANVLKLTSGLWREVVREVA-KEYPDVELDHMYVDAAAMQLVRNPEQFDVIVTEN 238

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291  249 MYGTILGNIGAALIGGPGLVAGANFGRDY-AVFEP--GSrhvGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISKA 325
Cdd:COG0473 239 LFGDILSDLAAGLTGSLGLAPSANIGDEGkALFEPvhGS---APDIAGKGIANPIATILSAAMMLRHLGEEEAADAIEAA 315

                       330       340       350
                ....*....|....*....|....*....|..
gi 6324291  326 VHETIAEGKHtTRDIGGSSSTTDFTNEIINKL 357
Cdd:COG0473 316 VEKVLAEGVR-TPDLGGKAGTSEMGDAIIAAL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
30-353 2.82e-93

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 282.26  E-value: 2.82e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291     30 TVTLIPGDGVGKEITDSVRTIFEAENIPIDWEtINIKQTD--------HKEGV-YEAVESLKRNKIGLKGLWHTP-ADQT 99
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLE-FEFEERDvggaaideTGEPLpDETLEACKKADAVLLGAVGGPkWDPA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291    100 GHGSLN--VALRKQLDIYANV---ALFKSLKG---VKTRIPDIDLIVIRENTEGEFSGLEHESVPG---VVESLKVMTRP 168
Cdd:pfam00180  80 GVRPENglLALRKELGLFANLrpaKVFPPLGDaspLKNEVEGVDIVIVRELTGGIYFGIEKGIKGSgneVAVDTKLYSRD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291    169 KTERIARFAFDFAKKYNRKSVTAVHKANIMKLGDgLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPS 248
Cdd:pfam00180 160 EIERIARVAFELARKRGRKKVTSVDKANVLKSSD-LWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPN 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291    249 MYGTILGNIGAALIGGPGLVAGANFGRD-YAVFEP--GSrhvGLDIKGQNVANPTAMILSSTLMLNH-LGLNEYATRISK 324
Cdd:pfam00180 239 LFGDILSDEASMLTGSLGLLPSASLGANgFGIFEPvhGS---APDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEA 315

                         330       340       350
                  ....*....|....*....|....*....|..
gi 6324291    325 AVHETIAEGKhTTRDIGGSS---STTDFTNEI 353
Cdd:pfam00180 316 AVLKVLESGI-RTGDLAGSAtyvSTSEFGEAV 346
 
Name Accession Description Interval E-value
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 26-357 0e+00

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 582.03  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291     26 GGRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIK-QTDHK-EGVYEAVESLKRNKIGLKGLWHTPADQTGHGS 103
Cdd:TIGR00175   1 GGKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSpQTDGKtEIPDEAVESIKRNKVALKGPLETPIGKGGHRS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291    104 LNVALRKQLDIYANVALFKSLKGVKTRIPDIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKK 183
Cdd:TIGR00175  81 LNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYARK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291    184 YNRKSVTAVHKANIMKLGDGLFRNIITEIGqKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIG 263
Cdd:TIGR00175 161 NGRKKVTAVHKANIMKLADGLFLNVCREVA-KEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVG 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291    264 GPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISKAVHETIAEGKHTTRDIGGS 343
Cdd:TIGR00175 240 GPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGGT 319

                         330
                  ....*....|....
gi 6324291    344 SSTTDFTNEIINKL 357
Cdd:TIGR00175 320 ATTSDFTEAVIKRL 333
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 4-357 1.16e-125

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 365.34  E-value: 1.16e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291     4 RTIAKRTLATAAQAERT--LPKKYGGR-FTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIkQTDHKEGVYEAVES 80
Cdd:PLN00123   3 KRLLSNALGSKAQRRSVtyMPRPGDGApRAVTLIPGDGIGPLVTGAVEQVMEAMHAPVYFERYEV-HGDMKKVPEEVLES 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291    81 LKRNKIGLKGLWHTPADqTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIPDIDLIVIRENTEGEFSGLEHESVPGVVE 160
Cdd:PLN00123  82 IRRNKVCLKGGLATPVG-GGVSSLNVQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYSGLEHEVVPGVVE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   161 SLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKeYPDIDVSSIIVDNASMQAVAKPHQ 240
Cdd:PLN00123 161 SLKVITKFCSERIAKYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKK-YPGIKYNEIIVDNCCMQLVSKPEQ 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   241 FDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRDYAVFEPGSRHVGL---DIKGQNVANPTAMILSSTLMLNHLGLNE 317
Cdd:PLN00123 240 FDVMVTPNLYGNLVANTAAGIAGGTGVMPGGNVGADHAVFEQGASAGNVgneKLVEQKKANPVALLLSSAMMLRHLQFPS 319

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 6324291   318 YATRISKAVHETIAEGKHTTRDIGGSSSTTDFTNEIINKL 357
Cdd:PLN00123 320 FADRLETAVKRVIAEGKYRTKDLGGSSTTQEVVDAVIANL 359
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 28-357 9.95e-124

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 359.71  E-value: 9.95e-124
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   28 RFTVTLIPGDGVGKEITDSVRTIFEA----ENIPIDWETINI-KQTDHKEGVY---EAVESLKRNKIGLKGLWHTPADQT 99
Cdd:COG0473   1 TYKIAVLPGDGIGPEVVAAALKVLEAaaerFGLDFEFEEADIgGAAYDKTGTPlpdETLEALRKADAILLGAVGGPKWDD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291  100 GHG--SLNVALRKQLDIYANVALFKSLKGVKTR-----IPDIDLIVIRENTEGEFSGLEHESVPG----VVESLKVMTRP 168
Cdd:COG0473  81 GVRpeSGLLALRKELDLYANLRPAKLYPGLPSPlkpeiVEGIDLVIVRENTEGLYFGIGGRIGTGtgeeVAIDTRVYTRK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291  169 KTERIARFAFDFAKKyNRKSVTAVHKANIMKLGDGLFRNIITEIGqKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPS 248
Cdd:COG0473 161 GIERIARYAFELARK-RRKKVTSVDKANVLKLTSGLWREVVREVA-KEYPDVELDHMYVDAAAMQLVRNPEQFDVIVTEN 238

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291  249 MYGTILGNIGAALIGGPGLVAGANFGRDY-AVFEP--GSrhvGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISKA 325
Cdd:COG0473 239 LFGDILSDLAAGLTGSLGLAPSANIGDEGkALFEPvhGS---APDIAGKGIANPIATILSAAMMLRHLGEEEAADAIEAA 315

                       330       340       350
                ....*....|....*....|....*....|..
gi 6324291  326 VHETIAEGKHtTRDIGGSSSTTDFTNEIINKL 357
Cdd:COG0473 316 VEKVLAEGVR-TPDLGGKAGTSEMGDAIIAAL 346
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 26-357 3.21e-120

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 351.87  E-value: 3.21e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291    26 GGRFTVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINI-KQTDHKEG---VYEAVESLKRNKIGLKGLWHTPADQtGH 101
Cdd:PLN00118  39 STPITATLFPGDGIGPEIAESVKQVFTAAGVPIEWEEHYVgTTVDPRTGsflTWESLESVRRNKVGLKGPMATPIGK-GH 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   102 GSLNVALRKQLDIYANVALFKSLKGVKTRIPDIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFA 181
Cdd:PLN00118 118 RSLNLTLRKELGLYANVRPCYSLPGYKTRYDDVDLVTIRENTEGEYSGLEHQVVRGVVESLKIITRQASLRVAEYAFHYA 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   182 KKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKeYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAAL 261
Cdd:PLN00118 198 KTHGRKRVSAIHKANIMKKTDGLFLKCCREVAEK-YPEIVYEEVIIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGL 276

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   262 IGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISKAVHETIAEGKHTTRDIG 341
Cdd:PLN00118 277 IGGLGLTPSCNIGENGLALAEAVHGSAPDIAGKNLANPTALLLSAVMMLRHLKLNEQAEQIHNAILNTIAEGKYRTADLG 356

                        330
                 ....*....|....*.
gi 6324291   342 GSSSTTDFTNEIINKL 357
Cdd:PLN00118 357 GSSTTTDFTKAICDHL 372
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
31-357 4.11e-109

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 327.23  E-value: 4.11e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291    31 VTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQTDHKEGVY-----EAVESLKRNKIGLKGLWHTPADQtGHGSLN 105
Cdd:PRK09222   7 ITVAYGDGIGPEIMEAVLKILEAAGAPLEIETIEIGEKVYKKGWTsgispSAWESIRRTKVLLKAPITTPQGG-GYKSLN 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   106 VALRKQLDIYANVALFKSLK-GVKTRIPDIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKKY 184
Cdd:PRK09222  86 VTLRKTLGLYANVRPCVSYHpFVETKHPNLDVVIIRENEEDLYAGIEHRQTPDVYQCLKLISRPGSEKIIRYAFEYARAN 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   185 NRKSVTAVHKANIMKLGDGLFRNIITEIGqKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGG 264
Cdd:PRK09222 166 GRKKVTCLTKDNIMKLTDGLFHKVFDEIA-KEYPDIEAEHYIVDIGAARLATNPENFDVIVTPNLYGDILSDIAAEISGS 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   265 PGLVAGANFGRDYAVFEP--GSrhvGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISKAVHETIAEGKHtTRDIGG 342
Cdd:PRK09222 245 VGLAGSANIGEEYAMFEAvhGS---APDIAGKNIANPSGLLNAAVMMLVHIGQFDIAELIENAWLKTLEDGIH-TADIYN 320

                        330       340
                 ....*....|....*....|.
gi 6324291   343 SS------STTDFTNEIINKL 357
Cdd:PRK09222 321 EGvskkkvGTKEFAEAVIENL 341
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 30-357 6.98e-105

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 311.27  E-value: 6.98e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291    30 TVTLIPGDGVGKEITDSVRTIFEAENIPIDWETINIKQT---DHKEGV-YEAVESLKRNKIGLKGLWHTPADQtGHGSLN 105
Cdd:PRK08997   4 TITVIPGDGIGPSIIDATLKILDKLGCDFEYEFADAGLTaleKHGELLpQRTLDLIEKNKIALKGPLTTPVGE-GFTSIN 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   106 VALRKQLDIYANVALFKSLKGVKTRIPDIDLIVIRENTEGEFSGLEHE-SVPG-VVESLKVMTRPKTERIARFAFDFAKK 183
Cdd:PRK08997  83 VTLRKKFDLYANVRPVLSFPGTKARYDNIDIITVRENTEGMYSGEGQTvSEDGeTAEATSIITRKGAERIVRFAYELARK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   184 YNRKSVTAVHKANIMKLGDGLFRNIITEIGQkEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIG 263
Cdd:PRK08997 163 EGRKKVTAVHKANIMKSTSGLFLKVAREVAL-RYPDIEFEEMIVDATCMQLVMNPEQFDVIVTTNLFGDILSDLCAGLVG 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   264 GPGLVAGANFGRDYAVFEP--GSrhvGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISKAVHETIAEGKHTTRDIG 341
Cdd:PRK08997 242 GLGMAPGANIGRDAAIFEAvhGS---APDIAGKNLANPTSVILAAIQMLEYLGMPDKAERIRKAIVAVIEAGDRTTRDLG 318

                        330
                 ....*....|....*.
gi 6324291   342 GSSSTTDFTNEIINKL 357
Cdd:PRK08997 319 GTHGTTDFTQAVIDRL 334
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
30-353 2.82e-93

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 282.26  E-value: 2.82e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291     30 TVTLIPGDGVGKEITDSVRTIFEAENIPIDWEtINIKQTD--------HKEGV-YEAVESLKRNKIGLKGLWHTP-ADQT 99
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLE-FEFEERDvggaaideTGEPLpDETLEACKKADAVLLGAVGGPkWDPA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291    100 GHGSLN--VALRKQLDIYANV---ALFKSLKG---VKTRIPDIDLIVIRENTEGEFSGLEHESVPG---VVESLKVMTRP 168
Cdd:pfam00180  80 GVRPENglLALRKELGLFANLrpaKVFPPLGDaspLKNEVEGVDIVIVRELTGGIYFGIEKGIKGSgneVAVDTKLYSRD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291    169 KTERIARFAFDFAKKYNRKSVTAVHKANIMKLGDgLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPS 248
Cdd:pfam00180 160 EIERIARVAFELARKRGRKKVTSVDKANVLKSSD-LWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPN 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291    249 MYGTILGNIGAALIGGPGLVAGANFGRD-YAVFEP--GSrhvGLDIKGQNVANPTAMILSSTLMLNH-LGLNEYATRISK 324
Cdd:pfam00180 239 LFGDILSDEASMLTGSLGLLPSASLGANgFGIFEPvhGS---APDIAGKGIANPIATILSAAMMLRYsLGLEDAADKIEA 315

                         330       340       350
                  ....*....|....*....|....*....|..
gi 6324291    325 AVHETIAEGKhTTRDIGGSS---STTDFTNEI 353
Cdd:pfam00180 316 AVLKVLESGI-RTGDLAGSAtyvSTSEFGEAV 346
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 31-357 2.23e-90

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 274.32  E-value: 2.23e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291    31 VTLIPGDGVGKEITDSVRTIFEAENIPidWETINIKQTDH---KEGVY---EAVESLKRNKIGLKG-LWHTPADQTghgs 103
Cdd:PRK14025   4 ICVIEGDGIGKEVVPAALHVLEATGLP--FEFVYAEAGDEvfeKTGKAlpeETIEAAKEADAVLFGaAGETAADVI---- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   104 lnVALRKQLDIYANVALFKSLKGVKTRIPDIDLIVIRENTEGEFSGLEHESVPGVVESLKVMTRPKTERIARFAFDFAKK 183
Cdd:PRK14025  78 --VKLRRILDTYANVRPVKSYKGVKCLYPDIDYVIVRENTEGLYKGIEAEIADGVTVATRVITRKASERIFRFAFEMAKR 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   184 ----YNRKSVTAVHKANIMKLGDGLFRNIITEIGqKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGA 259
Cdd:PRK14025 156 rkkmGKEGKVTCAHKANVLKKTDGLFKKTFYEVA-KEYPDIKAEDYYVDAMNMYIITRPQTFDVVVTSNLFGDILSDGAA 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   260 ALIGGPGLVAGANFGRDYAVFEP--GSrhvGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRISKAVHETIAEGKhTT 337
Cdd:PRK14025 235 GLVGGLGLAPSANIGDKYGLFEPvhGS---APDIAGKGIANPTATILTAVLMLRHLGENEEADKVEKALEEVLALGL-TT 310

                        330       340
                 ....*....|....*....|
gi 6324291   338 RDIGGSSSTTDFTNEIINKL 357
Cdd:PRK14025 311 PDLGGNLSTMEMAEEVAKRV 330
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 29-358 4.84e-73

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 230.76  E-value: 4.84e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291    29 FTVTLIPGDGVGKEITDSVRTIFEA----ENIPIDWET-----INIKQTDH---KEGVYE----------AV-----ESL 81
Cdd:PRK00772   3 YKIAVLPGDGIGPEVMAEAVKVLDAvaekFGFDFEFEEalvggAAIDAHGVplpEETLEAcraadavllgAVggpkwDNL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291    82 KRNKIGLKGLwhtpadqtghgslnVALRKQLDIYAN---VALFKSLKGVKTRIPDI----DLIVIRENTEGEFSGlEHES 154
Cdd:PRK00772  83 PPDVRPERGL--------------LALRKELGLFANlrpAKLYPGLADASPLKPEIvaglDILIVRELTGGIYFG-EPRG 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   155 VPGVVESLK-----VMTRPKTERIARFAFDFAKKYNRKsVTAVHKANIMKlGDGLFRNIITEIGqKEYPDIDVSSIIVDN 229
Cdd:PRK00772 148 REGLGGEERafdtmVYTREEIERIARVAFELARKRRKK-VTSVDKANVLE-SSRLWREVVTEVA-KEYPDVELSHMYVDN 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   230 ASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRD-YAVFEP--GSrhvGLDIKGQNVANPTAMILSS 306
Cdd:PRK00772 225 AAMQLVRNPKQFDVIVTENLFGDILSDEAAMLTGSLGMLPSASLGESgPGLYEPihGS---APDIAGKGIANPIATILSA 301

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 6324291   307 TLMLNH-LGLNEYATRISKAVHETIAEGkHTTRDI---GGSSSTTDFTNEIINKLS 358
Cdd:PRK00772 302 AMMLRYsLGLEEAADAIEAAVEKVLAQG-YRTADIaegGGKVSTSEMGDAILAALA 356
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 34-341 7.10e-56

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 185.90  E-value: 7.10e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291    34 IPGDGVGKEITDSVRTIFEAenipIDWETINIKQTD--------HKEGVY---EAVESLKRNKIGLKGLWHTPADQTG-- 100
Cdd:PRK03437  10 IPGDGIGPEVVAEALKVLDA----VAAGGPGVETTEydlgarryLRTGETlpdSVLAELRQHDAILLGAIGDPSVPSGvl 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   101 -HGSLnVALRKQLDIYANVALFKSLKGVKTRI---PDIDLIVIRENTEGEFSG--------LEHEsvpgVVESLKVMTRP 168
Cdd:PRK03437  86 eRGLL-LKLRFALDHYVNLRPSKLYPGVTSPLagpGDIDFVVVREGTEGPYTGnggalrvgTPHE----VATEVSVNTAF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   169 KTERIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGqKEYPDIDVSSIIVDNASMQAVAKPHQFDVLVTPS 248
Cdd:PRK03437 161 GVERVVRDAFERAQKRPRKHLTLVHKTNVLTFAGDLWQRTVDEVA-AEYPDVTVDYQHVDAATIFMVTDPSRFDVIVTDN 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   249 MYGTILGNIGAALIGGPGLVAGANF---GRDYAVFEP--GSrhvGLDIKGQNVANPTAMILSSTLMLNHLGLNEYATRIS 323
Cdd:PRK03437 240 LFGDIITDLAAAVTGGIGLAASGNInptGTNPSMFEPvhGS---APDIAGQGIADPTAAILSVALLLDHLGEEDAAARIE 316

                        330       340
                 ....*....|....*....|.
gi 6324291   324 KAVHETIAE---GKHTTRDIG 341
Cdd:PRK03437 317 AAVEADLAErgkMGRSTAEVG 337
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 34-359 1.93e-55

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 186.47  E-value: 1.93e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   34 IPGDGVGKEITDSVRTIFEA-------ENIPIDWETI-----NIKQTDHKEGVyEAVESLKRNKIGLKGLWHTPaDQTGH 101
Cdd:COG0538  24 IEGDGIGPEITRAIWKVIDAavekaygGKRDIEWKEVdagekARDETGDWLPD-ETAEAIKEYGVGIKGPLTTP-VGGGW 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291  102 GSLNVALRKQLDIYANVALFKSLKGVKTRIP---DIDLIVIRENTEGEFSGLEHES-VPGVVE----------------- 160
Cdd:COG0538 102 RSLNVTIRQILDLYVCRRPVRYFKGVPSPVKhpeKVDIVIFRENTEDIYAGIEWKAgSPEALKliffledemgvtvirfp 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291  161 -----SLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPD---------------- 219
Cdd:COG0538 182 edsgiGIKPVSDEGTERLVRAAIQYALDNKRKSVTLVHKGNIMKFTEGAFKDWGYEVAEEEFGDkfitegpwekykgpkp 261

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291  220 ---IDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRDY-AVFEP--GS--RHVgldi 291
Cdd:COG0538 262 agkIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANIGDDGgAEFEAthGTapKYA---- 337

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6324291  292 kGQNVANPTAMILSSTLMLNHLGLNEYATRISKAVHETIAEGKHT---TRDIGGSS--STTDFTNEIINKLST 359
Cdd:COG0538 338 -GKDSTNPGSLILSGTMMLRHRGWLEAADLIEKAVEKTIESGKVTydlARLMEGATelSTSEFGDAIIENLDK 409
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 29-357 2.18e-54

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 182.23  E-value: 2.18e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291    29 FTVTLIPGDGVGKEITDSVRTI------------FEAENIPIDWETInikqTDHKEGVYE-AVESLKRNKIGLKGLWHTP 95
Cdd:PRK08194   4 FKIAVIPGDGVGKEVVPAAVRVlkavaevhgglkFEFTEFPWSCEYY----LEHGEMMPEdGLEQLKQFDAIFLGAVGNP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291    96 ADQTGHGSL---NVALRKQLDIYANVALFKSLKGVKTRIP---DIDLIVIRENTEGEFS---GLEHESVPGVVESLKVMT 166
Cdd:PRK08194  80 KLVPDHISLwglLIKIRREFEQVINIRPAKQLRGIKSPLAnpkDFDLLVVRENSEGEYSevgGRIHRGEDEIAIQNAVFT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   167 RPKTERIARFAFDFAKKyNRKSVTAVHKAN----IMKLGDGLFRNIiteigQKEYPDIDVSSIIVDNASMQAVAKPHQFD 242
Cdd:PRK08194 160 RKGTERAMRYAFELAAK-RRKHVTSATKSNgivhSMPFWDEVFQEV-----GKDYPEIETDSQHIDALAAFFVTRPEEFD 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   243 VLVTPSMYGTILGNIGAALIGGPGLVAGANF---GRDYAVFEP--GSrhvGLDIKGQNVANPTAMILSSTLMLNHLGLNE 317
Cdd:PRK08194 234 VIVASNLFGDILTDIGAAIMGSIGIAPAANInvnGKYPSMFEPvhGS---APDIAGKGIANPIGQIWTAKLMLDHFGEEE 310

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 6324291   318 YATRISKAVHETIAEGkHTTRDIGGSSSTTDFTNEIINKL 357
Cdd:PRK08194 311 LGSHLLDVIEDVTEDG-IKTPDIGGRATTDEVTDEIISRL 349
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
34-360 4.08e-53

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 180.80  E-value: 4.08e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291    34 IPGDGVGKEITDSVRTIFEA-------ENIPIDW-ETINIKQTDHKEG---VYEAVESLKRNKIGLKGLWHTPADQtGHG 102
Cdd:PRK06451  29 VEGDGIGPEITHAAMKVINKavekaygSDREIKWvEVLAGDKAEKLTGnrfPKESEELIEKYRVLLKGPLETPIGK-GWK 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   103 SLNVALRKQLDIYANVALFKSLKGVKTRI--PD-IDLIVIRENTEGEFSGLEH----------------------ESVPG 157
Cdd:PRK06451 108 SINVAIRLMLDLYANIRPVKYIPGIESPLknPEkIDLIIFRENTDDLYRGIEYpydseeakkirdflrkelgvevEDDTG 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   158 VveSLKVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPD------------------ 219
Cdd:PRK06451 188 I--GIKLISKFKTQRIARMAIKYAIDHKRKKVTIMHKGNVMKYTEGAFREWAYEVALKEFRDyvvteeevtknyngvpps 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   220 --IDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRDYAVFEpgSRHvGLDIK--GQN 295
Cdd:PRK06451 266 gkVIINDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTGGMFE--AIH-GTAPKyaGKN 342

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   296 VANPTAMILSSTLMLNHLGLNEYATRISKAVHETIAEgKHTTRDIG-----GSSSTTDFTNEIINKLSTM 360
Cdd:PRK06451 343 VANPTGIIKGGELMLRFMGWDKAADLIDKAIMESIKQ-KKVTQDLArfmgvRALSTTEYTDELISIIDML 411
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 34-357 1.29e-44

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 158.30  E-value: 1.29e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291    34 IPGDGVGKEITDSVRTIFEAE-------NIPIDWETINIKQTDHK---EGVY---EAVESLKRNKIGLKGLWHTPadqTG 100
Cdd:PRK07006  25 IEGDGIGPDITPAMLKVVDAAvekaykgERKISWMEIYAGEKATKvygEDVWlpeETLDLIREYRVAIKGPLTTP---VG 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   101 HG--SLNVALRKQLDIYANVALFKSLKGVKT---RIPDIDLIVIRENTEGEFSGLEHES----VPGVVESL--------- 162
Cdd:PRK07006 102 GGirSLNVALRQELDLYVCLRPVRYFKGVPSpvkRPEDTDMVIFRENSEDIYAGIEWKAgsaeAKKVIKFLqeemgvkki 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   163 ----------KVMTRPKTERIARFAFDFAKKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPD------------- 219
Cdd:PRK07006 182 rfpetsgigiKPVSEEGTERLVRAAIEYAIDNDRKSVTLVHKGNIMKFTEGAFKDWGYQLAEEEFGDelidggpwdkikn 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   220 ------IDVSSIIVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRDYAVFEpgSRHvGLDIK- 292
Cdd:PRK07006 262 petgkeIIVKDSIADAFLQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGANINDGHAIFE--ATH-GTAPKy 338

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6324291   293 -GQNVANPTAMILSSTLMLNHLGLNEYATRISKAVHETIAEGKHT---TRDIGGSS--STTDFTNEIINKL 357
Cdd:PRK07006 339 aGLDKVNPGSVILSAEMMLRHMGWTEAADLIIKSMEKTIASKTVTydfARLMEGATevKCSEFGDALIKNM 409
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 28-336 7.04e-28

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 112.86  E-value: 7.04e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291    28 RFTVTLIPGDGVGKEITDSVRTI-----------FEAENIPIDWETINIKQTDHKEGVYEAVESLKRNKIGLKGLWHTPA 96
Cdd:PLN02329  46 RYNIALLPGDGIGPEVISVAKNVlqkagslegleFDFQEMPVGGAALDLVGVPLPEETFTAAKQSDAILLGAIGGYKWDK 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291    97 DQTgHGSLNVAL---RKQLDIYANV-------ALFKSLKGVKTRIPDIDLIVIRENTEGEFSGLE-----HESVPGVVES 161
Cdd:PLN02329 126 NEK-HLRPEMALfylRRDLKVFANLrpatvlpQLVDASTLKKEVAEGVDMMIVRELTGGIYFGEPrgitiNENGEEVGVS 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   162 LKVMTRPKTERIARFAFDFAKKyNRKSVTAVHKANIMKlGDGLFRNIITEIGQkEYPDIDVSSIIVDNASMQAVAKPHQF 241
Cdd:PLN02329 205 TEIYAAHEIDRIARVAFETARK-RRGKLCSVDKANVLD-ASILWRKRVTALAS-EYPDVELSHMYVDNAAMQLIRDPKQF 281

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   242 DVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRD-YAVFEP--GSrhvGLDIKGQNVANPTAMILSSTLMLNH-LGLNE 317
Cdd:PLN02329 282 DTIVTNNIFGDILSDEASMITGSIGMLPSASLGESgPGLFEPihGS---APDIAGQDKANPLATILSAAMLLKYgLGEEK 358

                        330
                 ....*....|....*....
gi 6324291   318 YATRISKAVHETIAEGKHT 336
Cdd:PLN02329 359 AAKRIEDAVVDALNKGFRT 377
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
78-336 2.97e-23

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 100.17  E-value: 2.97e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291    78 VESLKRNKIGLKGLWHTPadqTGHG--SLNVALRKQLDIYANVALFKSLKGVKT---RIPDIDLIVIRENTEGEFSGLEH 152
Cdd:PRK07362  91 LEAIREYGVAIKGPLTTP---IGGGirSLNVALRQIFDLYSCVRPCRYYAGTPSphkNPEKLDVIVYRENTEDIYMGIEW 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   153 ES----------------VPGVVE------------SLKVMTRPKTERIARFAFDFAKKY--NRKSVTAVHKANIMKLGD 202
Cdd:PRK07362 168 EAgdeigdklikhlneevIPASPElgkrqiplgsgiGIKPVSKTGSQRHIRRAIEHALRLpgDKRHVTLVHKGNIMKYTE 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   203 GLFRN-------------IITE-----IGQKE-YPDIDV------------------------------SSI-------- 225
Cdd:PRK07362 248 GAFRDwgyelattefrdeCVTEreswiLSNKEkNPNISIednarmiepgydsltpekkaaicaevkevlDSIwsshgngk 327

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324291   226 ----------IVDNASMQAVAKPHQFDVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRDYAVFEP----GSRHVGLDi 291
Cdd:PRK07362 328 wkekvlvddrIADSIFQQIQTRPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNAAIFEAthgtAPKHAGLD- 406

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 6324291   292 kgqnVANPTAMILSSTLMLNHLGLNEYATRISKAVHETIAEGKHT 336
Cdd:PRK07362 407 ----RINPGSVILSGVMMLEYLGWQEAADLITKGLSAAIANKQVT 447
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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