NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|27808717|ref|NP_014730|]
View 

Yvc1p [Saccharomyces cerevisiae S288C]

Protein Classification

ion transporter( domain architecture ID 11997982)

ion transporter such as a voltage-gated cation channel, which enables the selective translocation of cations such as sodium, calcium, or potassium across cell membranes

CATH:  1.10.287.70
Gene Ontology:  GO:0034220|GO:0005216|GO:0005886|GO:0034702
PubMed:  15816170
TCDB:  1.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 235-470 3.36e-09

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 57.66  E-value: 3.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808717   235 YQNYLQMIFSFLFLGLYTLVVNGKDSERVQSFDLLESIFYVFNTGFILDELTKLYYIGYAH---LSFWNLFnDTTYLIIT 311
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKryfRSPWNIL-DFVVVLPS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808717   312 FAMGFRAMSVTPLNakyssedwdkisYRVLSCaapFVWSRLLLYLESQRFIGIMLVILKHMMKESIVFFFLLFLIMIGFT 391
Cdd:pfam00520  80 LISLVLSSVGSLSG------------LRVLRL---LRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFA 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808717   392 QGFLGLDSADGKRDItGPILGN------------LTITVLGLGSFDVF----EEFAPPYAAILYYGYYFIVSVILLNILI 455
Cdd:pfam00520 145 IIGYQLFGGKLKTWE-NPDNGRtnfdnfpnaflwLFQTMTTEGWGDIMydtiDGKGEFWAYIYFVSFIILGGFLLLNLFI 223

                         250
                  ....*....|....*
gi 27808717   456 ALYSTAYQKVIDNAD 470
Cdd:pfam00520 224 AVIIDNFQELTERTE 238
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 235-470 3.36e-09

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 57.66  E-value: 3.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808717   235 YQNYLQMIFSFLFLGLYTLVVNGKDSERVQSFDLLESIFYVFNTGFILDELTKLYYIGYAH---LSFWNLFnDTTYLIIT 311
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKryfRSPWNIL-DFVVVLPS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808717   312 FAMGFRAMSVTPLNakyssedwdkisYRVLSCaapFVWSRLLLYLESQRFIGIMLVILKHMMKESIVFFFLLFLIMIGFT 391
Cdd:pfam00520  80 LISLVLSSVGSLSG------------LRVLRL---LRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFA 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808717   392 QGFLGLDSADGKRDItGPILGN------------LTITVLGLGSFDVF----EEFAPPYAAILYYGYYFIVSVILLNILI 455
Cdd:pfam00520 145 IIGYQLFGGKLKTWE-NPDNGRtnfdnfpnaflwLFQTMTTEGWGDIMydtiDGKGEFWAYIYFVSFIILGGFLLLNLFI 223

                         250
                  ....*....|....*
gi 27808717   456 ALYSTAYQKVIDNAD 470
Cdd:pfam00520 224 AVIIDNFQELTERTE 238
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 233-486 7.28e-09

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 58.94  E-value: 7.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808717   233 PVYQNYLQMIFSFLFLGLYTLVVNGkdservqSFDLLESIFYVFNTGfildeltklyyigyAHLSFWNLFND--TTYLII 310
Cdd:TIGR00870 390 PLEMLIVTWVDGLRLGEEKLIWLGG-------IFEYIHQLWNILDFG--------------MNSFYLATFLDrpFAILFV 448

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808717   311 TFAmgframsvtPLNAKYSSEDWDK--ISYRVLSCAAPFVWSRLLLYLESQRFIGIMLVILKHMMKESIVFFFLLFLI-- 386
Cdd:TIGR00870 449 TQA---------FLVLREHWLRFDPtlIEEALFAFALVLSWLNLLYIFRGNQHLGPLQIMIGRMILGDILRFLFIYAVvl 519

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808717   387 ---MIGFTQGFLGLDSADGKRDITGPILGNLTI----------------TVLGLGSFDVFE-EFAPPYAAILYYGYYFIV 446
Cdd:TIGR00870 520 fgfACGLNQLYQYYDELKLNECSNPHARSCEKQgnaystlfetsqelfwAIIGLGDLLANEhKFTEFVGLLLFGAYNVIM 599

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 27808717   447 SVILLNILIALYSTAYQKVIDNADDEYMALMSQKTLRYIR 486
Cdd:TIGR00870 600 YILLLNMLIAMMGNTYQLIADDADEEWKFQRAKLWMSYER 639
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 278-471 1.27e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 48.34  E-value: 1.27e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808717 278 TGFILDELTKLYYIGYAHLSFWNLFNDTTYLIITFAMGFraMSVTPLNAKYSSEDWDKISyrvLSCAAPFVWSRLLLYLE 357
Cdd:cd21882 353 LGGVYILLGEIPYFFRRRLSRWFGFLDSYFEILFITQAL--LVLLSMVLRFMETEGYVVP---LVFSLVLGWCNVLYYTR 427

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808717 358 SQRFIGIMLVILKHMMKESIVFFFLLFLIMI-GFTQGFLGL------DSADGKRDITGPILGNLTITvLGLGSFDVFEEF 430
Cdd:cd21882 428 GFQMLGIYTVMIQKMILRDLMRFCWVYLVFLfGFASAFVILfqtedpNKLGEFRDYPDALLELFKFT-IGMGDLPFNENV 506

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 27808717 431 APPYA-AILYYGYYFIVSVILLNILIALYSTAYQKVIDNADD 471
Cdd:cd21882 507 DFPFVyLILLLAYVILTYLLLLNMLIALMGETVNRVAQESDE 548
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 235-470 3.36e-09

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 57.66  E-value: 3.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808717   235 YQNYLQMIFSFLFLGLYTLVVNGKDSERVQSFDLLESIFYVFNTGFILDELTKLYYIGYAH---LSFWNLFnDTTYLIIT 311
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKryfRSPWNIL-DFVVVLPS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808717   312 FAMGFRAMSVTPLNakyssedwdkisYRVLSCaapFVWSRLLLYLESQRFIGIMLVILKHMMKESIVFFFLLFLIMIGFT 391
Cdd:pfam00520  80 LISLVLSSVGSLSG------------LRVLRL---LRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFA 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808717   392 QGFLGLDSADGKRDItGPILGN------------LTITVLGLGSFDVF----EEFAPPYAAILYYGYYFIVSVILLNILI 455
Cdd:pfam00520 145 IIGYQLFGGKLKTWE-NPDNGRtnfdnfpnaflwLFQTMTTEGWGDIMydtiDGKGEFWAYIYFVSFIILGGFLLLNLFI 223

                         250
                  ....*....|....*
gi 27808717   456 ALYSTAYQKVIDNAD 470
Cdd:pfam00520 224 AVIIDNFQELTERTE 238
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 233-486 7.28e-09

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 58.94  E-value: 7.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808717   233 PVYQNYLQMIFSFLFLGLYTLVVNGkdservqSFDLLESIFYVFNTGfildeltklyyigyAHLSFWNLFND--TTYLII 310
Cdd:TIGR00870 390 PLEMLIVTWVDGLRLGEEKLIWLGG-------IFEYIHQLWNILDFG--------------MNSFYLATFLDrpFAILFV 448

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808717   311 TFAmgframsvtPLNAKYSSEDWDK--ISYRVLSCAAPFVWSRLLLYLESQRFIGIMLVILKHMMKESIVFFFLLFLI-- 386
Cdd:TIGR00870 449 TQA---------FLVLREHWLRFDPtlIEEALFAFALVLSWLNLLYIFRGNQHLGPLQIMIGRMILGDILRFLFIYAVvl 519

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808717   387 ---MIGFTQGFLGLDSADGKRDITGPILGNLTI----------------TVLGLGSFDVFE-EFAPPYAAILYYGYYFIV 446
Cdd:TIGR00870 520 fgfACGLNQLYQYYDELKLNECSNPHARSCEKQgnaystlfetsqelfwAIIGLGDLLANEhKFTEFVGLLLFGAYNVIM 599

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 27808717   447 SVILLNILIALYSTAYQKVIDNADDEYMALMSQKTLRYIR 486
Cdd:TIGR00870 600 YILLLNMLIAMMGNTYQLIADDADEEWKFQRAKLWMSYER 639
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 278-471 1.27e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 48.34  E-value: 1.27e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808717 278 TGFILDELTKLYYIGYAHLSFWNLFNDTTYLIITFAMGFraMSVTPLNAKYSSEDWDKISyrvLSCAAPFVWSRLLLYLE 357
Cdd:cd21882 353 LGGVYILLGEIPYFFRRRLSRWFGFLDSYFEILFITQAL--LVLLSMVLRFMETEGYVVP---LVFSLVLGWCNVLYYTR 427

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808717 358 SQRFIGIMLVILKHMMKESIVFFFLLFLIMI-GFTQGFLGL------DSADGKRDITGPILGNLTITvLGLGSFDVFEEF 430
Cdd:cd21882 428 GFQMLGIYTVMIQKMILRDLMRFCWVYLVFLfGFASAFVILfqtedpNKLGEFRDYPDALLELFKFT-IGMGDLPFNENV 506

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 27808717 431 APPYA-AILYYGYYFIVSVILLNILIALYSTAYQKVIDNADD 471
Cdd:cd21882 507 DFPFVyLILLLAYVILTYLLLLNMLIALMGETVNRVAQESDE 548
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 340-475 2.14e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 44.62  E-value: 2.14e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808717 340 VLSCAAPFVWSRLLLYLESQRFIG---IML--VILKHMMKesivFFFLLFLIMIGFTQGF------LGLDSADGKRDITG 408
Cdd:cd22192 425 PMSLALVLGWCNVMYFARGFQMLGpftIMIqkIIFGDLMK----FCWLMFVVILGFSSAFymifqtEDPDSLGHFYDFPM 500

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808717 409 PILgnlTITVLGLGSFDVF---EEFAPPYAAILYYGYYFIVSVILLNILIALYSTAYQKVIDNADDEYMA 475
Cdd:cd22192 501 TLF---STFELFLGLIDGPanyTVDLPFMYKVLYTAFAVIAYLLMLNLLIAMMGDTHWRVAHERDELWRA 567
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
 268-465 4.76e-04

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 42.26  E-value: 4.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808717   268 LLESIFYVFNTGFILDELTKLYYIGYAHL-SFWNLFNDTTYLIITFAMGFRAMS---VTPLNAKYSSEDWDKISYRVLS- 342
Cdd:pfam08016  12 LCEIVFVVFFLYFVVEEILKIRKHRPSYLrSVWNLLDLAIVILSVVLIVLNIYRdflADRLIKSVEASPVTFIDFDRVAq 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27808717   343 ----------CAAPFVWSRLLLYLesqRFIGIMLVI---LKHMMKESIVFFFLLFLIMIGFTQ-GFLGLDS-ADGKRDIT 407
Cdd:pfam08016  92 ldnlyriilaFLVFLTWLKLFKVL---RFNKTMSLFtktLSRAWKDLAGFALMFVIFFFAYAQfGYLLFGTqAPNFSNFV 168

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 27808717   408 GPILgNLTITVLGLGSFDVFEEFAPPYAAILYYGYYFIVSVILLNILIALYSTAYQKV 465
Cdd:pfam08016 169 KSIL-TLFRTILGDFGYNEIFSGNRVLGPLLFLTFVFLVIFILLNLFLAIINDSYVEV 225
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH