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Conserved domains on  [gi|398365871|ref|NP_014875|]
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Mge1p [Saccharomyces cerevisiae S288C]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 83-222 6.29e-58

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


:

Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 179.62  E-value: 6.29e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  83 ELKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLESVDNFGHALNAFKEEDlqkskEISDLYTGVRMTRDVFEN 162
Cdd:cd00446    2 ELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKEE-----ELKNLLEGVEMTLKQLLK 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871 163 TLRKHGIEKLDPLGEPFDPNKHEATFELPQPDKEPGTVFHVQQLGFTLNDRVIRPAKVGI 222
Cdd:cd00446   77 VLEKHGVEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
 
Name Accession Description Interval E-value
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 83-222 6.29e-58

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 179.62  E-value: 6.29e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  83 ELKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLESVDNFGHALNAFKEEDlqkskEISDLYTGVRMTRDVFEN 162
Cdd:cd00446    2 ELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKEE-----ELKNLLEGVEMTLKQLLK 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871 163 TLRKHGIEKLDPLGEPFDPNKHEATFELPQPDKEPGTVFHVQQLGFTLNDRVIRPAKVGI 222
Cdd:cd00446   77 VLEKHGVEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE pfam01025
GrpE;
55-224 6.14e-56

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 175.49  E-value: 6.14e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871   55 ENNEDLTEEQSEIKKLESQLSAKTKEASELKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLESVDNFGHALNA 134
Cdd:pfam01025   1 EEKKNEEALTDEIESLEEEIEELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  135 FKEEDlqkskEISDLYTGVRMTRDVFENTLRKHGIEKLDPLGEPFDPNKHEATFELPQPDKEPGTVFHVQQLGFTLNDRV 214
Cdd:pfam01025  81 APENE-----DVKSLLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSPEKPEGTVVEVLQKGYKLHDRV 155

                         170
                  ....*....|
gi 398365871  215 IRPAKVGIVK 224
Cdd:pfam01025 156 LRPAMVVVSK 165
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 75-225 7.54e-53

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 167.25  E-value: 7.54e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  75 SAKTKEASELKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLESVDNFGHALNAfkeedLQKSKEISDLYTGVR 154
Cdd:COG0576    2 EELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAA-----AEEDEDVKSLLEGVE 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 398365871 155 MTRDVFENTLRKHGIEKLDPLGEPFDPNKHEATFELPQPDKEPGTVFHVQQLGFTLNDRVIRPAKVGIVKG 225
Cdd:COG0576   77 MTLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSPDVEPGTVVEVLQKGYRLGDRVLRPAMVVVAKG 147
PRK14141 PRK14141
heat shock protein GrpE; Provisional
 46-225 6.80e-45

heat shock protein GrpE; Provisional


Pssm-ID: 172630  Cd Length: 209  Bit Score: 149.05  E-value: 6.80e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  46 DEAKSEESKENNEDLTEEQSEIKKLEsqlsAKTKEASELKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLESV 125
Cdd:PRK14141  16 RDANNPVDREAKPYEMEDDPEPDPLE----ALKAENAELKDRMLRLAAEMENLRKRTQRDVADARAYGIAGFARDMLSVS 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871 126 DNFGHALNAFKEEdlqkSKEISD-----LYTGVRMTRDVFENTLRKHGIEKLDPLGEPFDPNKHEATFELPQPDKEPGTV 200
Cdd:PRK14141  92 DNLRRALDAIPAE----ARAAADaglkaLIEGVEMTERAMLNALERHGVKKLDPEGQKFDPNFHQAMFEVPNPDVPNNTV 167

                        170       180
                 ....*....|....*....|....*
gi 398365871 201 FHVQQLGFTLNDRVIRPAKVGIVKG 225
Cdd:PRK14141 168 VQVVQAGYTIGERVLRPAMVGVAKG 192
 
Name Accession Description Interval E-value
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 83-222 6.29e-58

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 179.62  E-value: 6.29e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  83 ELKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLESVDNFGHALNAFKEEDlqkskEISDLYTGVRMTRDVFEN 162
Cdd:cd00446    2 ELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKEE-----ELKNLLEGVEMTLKQLLK 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871 163 TLRKHGIEKLDPLGEPFDPNKHEATFELPQPDKEPGTVFHVQQLGFTLNDRVIRPAKVGI 222
Cdd:cd00446   77 VLEKHGVEEIEPEGEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE pfam01025
GrpE;
55-224 6.14e-56

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 175.49  E-value: 6.14e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871   55 ENNEDLTEEQSEIKKLESQLSAKTKEASELKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLESVDNFGHALNA 134
Cdd:pfam01025   1 EEKKNEEALTDEIESLEEEIEELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  135 FKEEDlqkskEISDLYTGVRMTRDVFENTLRKHGIEKLDPLGEPFDPNKHEATFELPQPDKEPGTVFHVQQLGFTLNDRV 214
Cdd:pfam01025  81 APENE-----DVKSLLEGVEMTLKQLLKILEKHGVEKIEPEGEPFDPNLHEAVSQVPSPEKPEGTVVEVLQKGYKLHDRV 155

                         170
                  ....*....|
gi 398365871  215 IRPAKVGIVK 224
Cdd:pfam01025 156 LRPAMVVVSK 165
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 75-225 7.54e-53

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 167.25  E-value: 7.54e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  75 SAKTKEASELKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLESVDNFGHALNAfkeedLQKSKEISDLYTGVR 154
Cdd:COG0576    2 EELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAA-----AEEDEDVKSLLEGVE 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 398365871 155 MTRDVFENTLRKHGIEKLDPLGEPFDPNKHEATFELPQPDKEPGTVFHVQQLGFTLNDRVIRPAKVGIVKG 225
Cdd:COG0576   77 MTLKQLLDVLEKHGVEEIEPVGEPFDPNLHEAVSQVPSPDVEPGTVVEVLQKGYRLGDRVLRPAMVVVAKG 147
PRK14141 PRK14141
heat shock protein GrpE; Provisional
 46-225 6.80e-45

heat shock protein GrpE; Provisional


Pssm-ID: 172630  Cd Length: 209  Bit Score: 149.05  E-value: 6.80e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  46 DEAKSEESKENNEDLTEEQSEIKKLEsqlsAKTKEASELKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLESV 125
Cdd:PRK14141  16 RDANNPVDREAKPYEMEDDPEPDPLE----ALKAENAELKDRMLRLAAEMENLRKRTQRDVADARAYGIAGFARDMLSVS 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871 126 DNFGHALNAFKEEdlqkSKEISD-----LYTGVRMTRDVFENTLRKHGIEKLDPLGEPFDPNKHEATFELPQPDKEPGTV 200
Cdd:PRK14141  92 DNLRRALDAIPAE----ARAAADaglkaLIEGVEMTERAMLNALERHGVKKLDPEGQKFDPNFHQAMFEVPNPDVPNNTV 167

                        170       180
                 ....*....|....*....|....*
gi 398365871 201 FHVQQLGFTLNDRVIRPAKVGIVKG 225
Cdd:PRK14141 168 VQVVQAGYTIGERVLRPAMVGVAKG 192
PRK14150 PRK14150
heat shock protein GrpE; Provisional
 47-220 1.88e-37

heat shock protein GrpE; Provisional


Pssm-ID: 184539 [Multi-domain]  Cd Length: 193  Bit Score: 129.27  E-value: 1.88e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  47 EAKSEESKENNEdLTEEQSEIKKLESQLSAKTKEAselKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLESVD 126
Cdd:PRK14150  24 QEEADEAELEDE-LDEADARIAELEAQLAEAQAEE---RDSVLRARAEVENIRRRAEQDVEKAHKFALEKFANELLPVID 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871 127 NFGHALNAFKEEDlqksKEISDLYTGVRMTRDVFENTLRKHGIEKLDPLGEPFDPNKHEATFELPQPDKEPGTVFHVQQL 206
Cdd:PRK14150 100 NLERALQAADKEN----EALKALIEGVELTLKSLLDTVAKFGVEVVGPVGEPFNPEVHQAISMQESEDHEPNTVMMVMQK 175

                        170
                 ....*....|....
gi 398365871 207 GFTLNDRVIRPAKV 220
Cdd:PRK14150 176 GYTLNGRLLRPAMV 189
PRK14151 PRK14151
heat shock protein GrpE; Provisional
 46-224 1.19e-36

heat shock protein GrpE; Provisional


Pssm-ID: 172640 [Multi-domain]  Cd Length: 176  Bit Score: 126.82  E-value: 1.19e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  46 DEAKSEESKENNEDLTEEQSEIKKLESQLSAKtkeaselKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLESV 125
Cdd:PRK14151   8 DLQAPEAAQAEAAAGDDLTARVQELEEQLAAA-------KDQSLRAAADLQNVRRRAEQDVEKAHKFALEKFAGDLLPVV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871 126 DNFGHALNAFKEEDlqksKEISDLYTGVRMTRDVFENTLRKHGIEKLDPLGEPFDPNKHEATFELPQPDKEPGTVFHVQQ 205
Cdd:PRK14151  81 DSLERGLELSSADD----EAIKPMREGVELTLKMFQDTLKRYQLEAVDPHGEPFNPEHHQAMAMQESADVEPNSVLKVFQ 156

                        170
                 ....*....|....*....
gi 398365871 206 LGFTLNDRVIRPAKVGIVK 224
Cdd:PRK14151 157 KGYLLNGRLLRPAMVVVSK 175
PRK14140 PRK14140
heat shock protein GrpE; Provisional
 45-220 7.47e-33

heat shock protein GrpE; Provisional


Pssm-ID: 237622 [Multi-domain]  Cd Length: 191  Bit Score: 117.41  E-value: 7.47e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  45 SDEAKSEESKENNEDLTEEQSEIKKLEsqlsaktKEASELKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLES 124
Cdd:PRK14140  24 EVEEETVEEESEAELLDEEQAKIAELE-------AKLDELEERYLRLQADFENYKRRIQKENEAAEKYRAQSLASDLLPA 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871 125 VDNFGHALNAFKEEDLQKSkeisdLYTGVRMTRDVFENTLRKHGIEKLDPLGEPFDPNKHEATFELPQPDKEPGTVFHVQ 204
Cdd:PRK14140  97 LDNFERALQIEADDEQTKS-----LLKGVEMVHRQLLEALKKEGVEVIEAVGEQFDPNLHQAVMQDEDEDFESNEVVEEL 171

                        170
                 ....*....|....*.
gi 398365871 205 QLGFTLNDRVIRPAKV 220
Cdd:PRK14140 172 QKGYKLKDRVIRPSMV 187
PRK14139 PRK14139
heat shock protein GrpE; Provisional
 45-226 5.93e-29

heat shock protein GrpE; Provisional


Pssm-ID: 237621 [Multi-domain]  Cd Length: 185  Bit Score: 106.98  E-value: 5.93e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  45 SDEAKSEESKENNEDLTEEQSEIKKLESQLSAKTKEASELKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLES 124
Cdd:PRK14139  12 EAEEAGAAAQAAAAAAAAAEDAAPALEAELAEAEAKAAELQDSFLRAKAETENVRRRAQEDVAKAHKFAIESFAESLLPV 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871 125 VDNFGHALnAFKEEDLQKSKEisdlytGVRMTRDVFENTLRKHGIEKLDPLGEPFDPNKHEATFELPQpDKEPGTVFHVQ 204
Cdd:PRK14139  92 KDSLEAAL-ADESGDLEKLRE------GVELTLKQLTSAFEKGRVVEINPVGEKFDPHQHQAISMVPA-EQEPNTVVAVL 163

                        170       180
                 ....*....|....*....|..
gi 398365871 205 QLGFTLNDRVIRPAKVGIVKGE 226
Cdd:PRK14139 164 QKGYTIADRVLRPALVTVAAPK 185
PRK14161 PRK14161
heat shock protein GrpE; Provisional
 51-224 2.25e-28

heat shock protein GrpE; Provisional


Pssm-ID: 237630 [Multi-domain]  Cd Length: 178  Bit Score: 105.44  E-value: 2.25e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  51 EESKENNEDLTEEQSEIKKLEsqLSAKTKEASELKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLESVDNFGH 130
Cdd:PRK14161   7 ENNEQTINDIAEEIVETANPE--ITALKAEIEELKDKLIRTTAEIDNTRKRLEKARDEAKDYAIATFAKELLNVSDNLSR 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871 131 ALnafKEEDLQKSKEISDLYTGVRMTRDVFENTLRKHGIEKLDP-LGEPFDPNKHEATFELPQPDKEPGTVFHVQQLGFT 209
Cdd:PRK14161  85 AL---AHKPANSDVEVTNIIAGVQMTKDELDKVFHKHHIEEIKPeIGSMFDYNLHNAISQIEHPDHAPNSIITLMQSGYK 161

                        170
                 ....*....|....*
gi 398365871 210 LNDRVIRPAKVGIVK 224
Cdd:PRK14161 162 IRDRLLRPATVQVVK 176
PRK14144 PRK14144
heat shock protein GrpE; Provisional
 44-224 2.55e-28

heat shock protein GrpE; Provisional


Pssm-ID: 184535 [Multi-domain]  Cd Length: 199  Bit Score: 105.96  E-value: 2.55e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  44 YSDEAKSEESKENN--EDLTEEQSEIKK----------LESQLSAKTKEASELKDRLLRSVADFRNLQQVTKKDIQKAKD 111
Cdd:PRK14144  12 FKDEHKEEHKVENEilEEETDEESQHQEpalghpsytaLEEQLTLAEQKAHENWEKSVRALAELENVRRRMEREVANAHK 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871 112 FALQKFAKDLLESVDNFGHALN-AFKEEDlqkskeiSDLYTGVRMTRDVFENTLRKHGIEKLDPLGEPFDPNKHEATFEL 190
Cdd:PRK14144  92 YGVEKLISALLPVVDSLEQALQlADKNSD-------PSMHEGLELTMKLFLDALQKFDVEQIDPLGQTFDPQQHEAMSMQ 164

                        170       180       190
                 ....*....|....*....|....*....|....
gi 398365871 191 PQPDKEPGTVFHVQQLGFTLNDRVIRPAKVGIVK 224
Cdd:PRK14144 165 PAPGAPPNSVITVFQKGYKLSDRVIRPARVIVST 198
PRK14159 PRK14159
heat shock protein GrpE; Provisional
 51-224 3.75e-28

heat shock protein GrpE; Provisional


Pssm-ID: 172647 [Multi-domain]  Cd Length: 176  Bit Score: 104.77  E-value: 3.75e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  51 EESKENNEDLTEEQSEIKKlESQLSAKTKEASELKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLESVDNFGH 130
Cdd:PRK14159  10 NENAENSEHLQDENLQNIE-DVEQNKLQKDYDELKDKYMRANAEFENIKKRMEKEKLSAMAYANESFAKDLLDVLDALEA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871 131 ALNAFKEEDLQ-KSKEisdlytGVRMTRDVFENTLRKHGIEKLDPLGEpFDPNKHEATFELPQPDKEPGTVFHVQQLGFT 209
Cdd:PRK14159  89 AVNVECHDEISlKIKE------GVQNTLDLFLKKLEKHGVALIKEEKE-FDPNLHEAMFHVDSENHQSGEVVQVLQKGYK 161

                        170
                 ....*....|....*
gi 398365871 210 LNDRVIRPAKVGIVK 224
Cdd:PRK14159 162 IADRVIRPTKVSVAK 176
PRK14155 PRK14155
heat shock protein GrpE; Provisional
 53-222 9.34e-28

heat shock protein GrpE; Provisional


Pssm-ID: 237627 [Multi-domain]  Cd Length: 208  Bit Score: 104.66  E-value: 9.34e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  53 SKENN--EDLTEEQSEikkLESQLSAKTKEASELKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLESVDNFGH 130
Cdd:PRK14155   2 TDEQTpaEDGPFEADD---AAQEIEALKAEVAALKDQALRYAAEAENTKRRAEREMNDARAYAIQKFARDLLGAADNLGR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871 131 ALnAFKEEDLQKSKeISDLYTGVRMTRDVFENTLRKHGIEKLDP-LGEPFDPNKHEATFELPQPDKEPGTVFHVQQLGFT 209
Cdd:PRK14155  79 AT-AASPKDSADPA-VKNFIIGVEMTEKELLGAFERNGLKKIDPaKGDKFDPHLHQAMMEQPSTEVAAGGVLQVMQAGYE 156

                        170
                 ....*....|...
gi 398365871 210 LNDRVIRPAKVGI 222
Cdd:PRK14155 157 LMGRLVRPAMVAV 169
PRK14148 PRK14148
heat shock protein GrpE; Provisional
 47-224 2.03e-27

heat shock protein GrpE; Provisional


Pssm-ID: 172637 [Multi-domain]  Cd Length: 195  Bit Score: 103.68  E-value: 2.03e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  47 EAKSEESKENNEDLTEEQsEIKKLESQLSAKTKEASELKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLESVD 126
Cdd:PRK14148  23 ETAQESASGALEELSVEE-QLERAKDTIKELEDSCDQFKDEALRAKAEMENIRKRAERDVSNARKFGIEKFAKELLPVID 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871 127 NFGHALnafKEEdlQKSKEISDLYTGVRMTRDVFENTLRKHGIEKLDPLGEPFDPNKHEATFELPQPDKEPGTVFHVQQL 206
Cdd:PRK14148 102 SIEQAL---KHE--VKLEEAIAMKEGIELTAKMLVDILKKNGVEELDPKGEKFDPNLHEAMAMIPNPEFEDNTIFDVFQK 176

                        170
                 ....*....|....*...
gi 398365871 207 GFTLNDRVIRPAKVGIVK 224
Cdd:PRK14148 177 GYMLNGRIVRAAKVVIVK 194
PRK10325 PRK10325
heat shock protein GrpE; Provisional
 46-226 1.12e-26

heat shock protein GrpE; Provisional


Pssm-ID: 182379 [Multi-domain]  Cd Length: 197  Bit Score: 101.67  E-value: 1.12e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  46 DEAKSEESKENNEDLTEEQSEIKKLESQLS-AKTKEaselKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLES 124
Cdd:PRK10325  23 EEIEAVEPEASAEQVDPRDEKIANLEAQLAeAQTRE----RDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPV 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871 125 VDNFGHALNAFKEEDlqksKEISDLYTGVRMTRDVFENTLRKHGIEKLDPLGEPFDPNKHEATFELPQPDKEPGTVFHVQ 204
Cdd:PRK10325  99 IDSLDRALEVADKAN----PDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIM 174

                        170       180
                 ....*....|....*....|..
gi 398365871 205 QLGFTLNDRVIRPAKVGIVKGE 226
Cdd:PRK10325 175 QKGYTLNGRTIRAAMVTVAKAK 196
PRK14149 PRK14149
heat shock protein GrpE; Provisional
 47-224 1.42e-26

heat shock protein GrpE; Provisional


Pssm-ID: 184538 [Multi-domain]  Cd Length: 191  Bit Score: 101.10  E-value: 1.42e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  47 EAKSEESKENNEDLTEEQSEIK-KLESQLSAKTKEaseLKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLESV 125
Cdd:PRK14149  20 EEKACACKEQQGEEKQEASEKEgEIKEDFELKYKE---MHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVI 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871 126 DNFGHALNAFKEEDlqkskEISDLYTGVRMTRDVFENTLRKHGIEKLDPLGEpFDPNKHEATFELPQPDKEPGTVFHVQQ 205
Cdd:PRK14149  97 DALLGALKSAAEVD-----KESALTKGLELTMEKLHEVLARHGIEGIECLEE-FDPNFHNAIMQVKSEEKENGKIVQVLQ 170

                        170
                 ....*....|....*....
gi 398365871 206 LGFTLNDRVIRPAKVGIVK 224
Cdd:PRK14149 171 QGYKYKGRVLRPAMVSIAK 189
PRK14162 PRK14162
heat shock protein GrpE; Provisional
 45-220 2.78e-25

heat shock protein GrpE; Provisional


Pssm-ID: 237631 [Multi-domain]  Cd Length: 194  Bit Score: 97.98  E-value: 2.78e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  45 SDEAKSEESKENNEDLTEEQSEIKKLESQLSAKTKEASELKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLES 124
Cdd:PRK14162  19 DEAPKKEAKEAPKEEDQEKQNPVEDLEKEIADLKAKNKDLEDKYLRSQAEIQNMQNRYAKERAQLIKYESQSLAKDVLPA 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871 125 VDNFGHALNAFKEEDLQKSkeisdLYTGVRMTRDVFENTLRKHGIEKLDPLGEPFDPNKHEATFELPQPDKEP-GTVFHV 203
Cdd:PRK14162  99 MDNLERALAVKADDEAAKQ-----LKKGVQMTLDHLVKALKDHGVTEIKADGEKFDPTLHQAVQTVAAENDDQkDHVVQV 173

                        170
                 ....*....|....*..
gi 398365871 204 QQLGFTLNDRVIRPAKV 220
Cdd:PRK14162 174 LQKGYQYKDRTLRPAMV 190
PRK14147 PRK14147
heat shock protein GrpE; Provisional
 56-224 5.94e-25

heat shock protein GrpE; Provisional


Pssm-ID: 237625 [Multi-domain]  Cd Length: 172  Bit Score: 96.56  E-value: 5.94e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  56 NNEDLTEEQSEIKKLESQLSAKTKEASELKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLESVDNFGHALNAf 135
Cdd:PRK14147   9 DSEDLAQNPPETDPLKAEVESLRSEIALVKADALRERADLENQRKRIARDVEQARKFANEKLLGELLPVFDSLDAGLTA- 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871 136 keedlqKSKEISDLYTGVRMTRDVFENTLRKHGIEKLDPLGEPFDPNKHEATFELPQPDKEPGTVFHVQQLGFTLNDRVI 215
Cdd:PRK14147  88 ------AGTEPSPLRDGLELTYKQLLKVAADNGLTLLDPVGQPFNPEHHQAISQGEAEGVAPGHVVQVFQKGYLLNERLL 161


                 ....*....
gi 398365871 216 RPAKVGIVK 224
Cdd:PRK14147 162 RPALVVVAK 170
PRK14153 PRK14153
heat shock protein GrpE; Provisional
 45-227 2.85e-24

heat shock protein GrpE; Provisional


Pssm-ID: 184540 [Multi-domain]  Cd Length: 194  Bit Score: 95.29  E-value: 2.85e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  45 SDEAKSEESKENNEDLTEEqSEIKKLESQLSAKTKEASELKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLES 124
Cdd:PRK14153  14 SEARNSGSSAEEAEELKEE-PEDSTADSETEKCREEIESLKEQLFRLAAEFDNFRKRTAREMEENRKFVLEQVLLDLLEV 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871 125 VDNFGHALnafkeEDLQKSKEISDLYTGVRMTRDVFENTLRKHGIEKLDPLGEPFDPNKHEATFELPQPDKEPGTVFHVQ 204
Cdd:PRK14153  93 TDNFERAL-----ESARTAEDMNSIVEGIEMVSKQFFSILEKYGLERIECEGEEFDPHRHEAMMHVETSEVPDNTIVDVC 167

                        170       180
                 ....*....|....*....|...
gi 398365871 205 QLGFTLNDRVIRPAKVGIVKGEE 227
Cdd:PRK14153 168 KPGYALNSKVIRPAMVSVARNPD 190
PRK14158 PRK14158
heat shock protein GrpE; Provisional
 45-224 4.45e-24

heat shock protein GrpE; Provisional


Pssm-ID: 172646 [Multi-domain]  Cd Length: 194  Bit Score: 94.61  E-value: 4.45e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  45 SDEAKSEESKENNEDLTEEQSEIKKLESQLSAKTKEASELKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLES 124
Cdd:PRK14158  20 AKEAEAAQGKPEAAQPVAAADRIKELEEALAAKEAEAAANWDKYLRERADLENYRKRVQKEKEELLKYGNESLILEILPA 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871 125 VDNFGHALNAFKEEDLqkskeiSDLYTGVRMTRDVFENTLRKHGIEKLD-PLGEPFDPNKHEATFELPQPDKEPGTVFHV 203
Cdd:PRK14158 100 VDNMERALDHADEESM------SAIIEGIRMTLSMLLSTLKKFGVTPVEaEKGTPFDPAYHQAMCQVESAEQEPNTVVAV 173

                        170       180
                 ....*....|....*....|.
gi 398365871 204 QQLGFTLNDRVIRPAKVGIVK 224
Cdd:PRK14158 174 FQKGYLLNERLLRPAMVSVAT 194
PRK14154 PRK14154
heat shock protein GrpE; Provisional
 68-225 1.64e-23

heat shock protein GrpE; Provisional


Pssm-ID: 237626 [Multi-domain]  Cd Length: 208  Bit Score: 93.72  E-value: 1.64e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  68 KKLESQLSAKTKEASELKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLESVDNFGHALNAFKEEDLQkskeIS 147
Cdd:PRK14154  55 EKLEGQLTRMERKVDEYKTQYLRAQAEMDNLRKRIEREKADIIKFGSKQLITDLLPVADSLIHGLESPASEDPQ----VK 130

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 398365871 148 DLYTGVRMTRDVFENTLRKHGIEKLDP-LGEPFDPNKHEATFELPQPDKEPGTVFHVQQLGFTLNDRVIRPAKVgIVKG 225
Cdd:PRK14154 131 SMRDGMSLTLDLLHNTLAKHGVQVINPnPGDPFDPALHEAMSVQAVPDAKPDTIIQVLQKGYQLNGRVLRAARV-IVAG 208
PRK14146 PRK14146
heat shock protein GrpE; Provisional
 49-224 2.97e-18

heat shock protein GrpE; Provisional


Pssm-ID: 172635 [Multi-domain]  Cd Length: 215  Bit Score: 79.78  E-value: 2.97e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  49 KSEESKENNEDLTEEQSE----IKKLESQLSAKTKEASELKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLES 124
Cdd:PRK14146  34 NSEESQTITEETQEQAVEgaetETSLQKELDNAKKEIESLKDSWARERAEFQNFKRRSAQEFVSIRKEAVKSLVSGFLNP 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871 125 VDNFGHALNAfkeedLQKSKEISDLYTGVRMTRDVFENTLRKHGIEKLDPLGEPFDPNKHEATFELPQPDKEPGTVFHVQ 204
Cdd:PRK14146 114 IDNLERVGAT-----QNQSEELKPFVEGVKMILKEFYSVLEKSNVIRFDPKGEPFDPMSMEALSSEEGDQYSEETVIDVY 188

                        170       180
                 ....*....|....*....|....
gi 398365871 205 QLGFTLND----RVIRPAKVGIVK 224
Cdd:PRK14146 189 QAGYYYKEnedkFTLRPARVRIGK 212
PRK14160 PRK14160
heat shock protein GrpE; Provisional
 45-216 4.63e-18

heat shock protein GrpE; Provisional


Pssm-ID: 237629 [Multi-domain]  Cd Length: 211  Bit Score: 79.03  E-value: 4.63e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  45 SDEAKSEESKENNEDLTEE-QSEIKKLESQLSAKTKEASELKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLE 123
Cdd:PRK14160  40 EKEEIIEDSEESNEVKIEElKDENNKLKEENKKLENELEALKDRLLRTVAEYDNYRKRTAKEKEGIYSDACEDVLKELLP 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871 124 SVDNFGHALNAfkeedlqkSKEISDLYTGVRMTRDVFENTLRKHGIEKLDPLGEpFDPNKHEATFELPQPDKEPGTVFHV 203
Cdd:PRK14160 120 VLDNLERAAAV--------EGSVEDLKKGIEMTVKQFKTSLEKLGVEEISTEGE-FDPNLHNAVMHVEDENYGENEIVEV 190

                        170
                 ....*....|...
gi 398365871 204 QQLGFTLNDRVIR 216
Cdd:PRK14160 191 FQKGYKRGDKVIR 203
PRK14145 PRK14145
heat shock protein GrpE; Provisional
 33-224 2.12e-17

heat shock protein GrpE; Provisional


Pssm-ID: 184536 [Multi-domain]  Cd Length: 196  Bit Score: 77.27  E-value: 2.12e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  33 KNVGSMRRMRFYSDEAKSEESKENNEDLteeqSEIKKLESQLSAKTKEASELKDRLLRSVADFRNLQQVTKKDIQKAKDF 112
Cdd:PRK14145  17 NNLSSNEQMEGPPEDEQAQQNQPQQQTV----DEIEELKQKLQQKEVEAQEYLDIAQRLKAEFENYRKRTEKEKSEMVEY 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871 113 ALQKFAKDLLESVDNFghalnafkEEDLQKSKEISDLYTGVRMTRDVFENTLRKHGIEKLDPLGEPFDPNKHEATFELPQ 192
Cdd:PRK14145  93 GKEQVILELLPVMDNF--------ERALASSGDYNSLKEGIELIYRQFKKILDKFGVKEIEAEGQIFDPYKHHAVMQEEV 164

                        170       180       190
                 ....*....|....*....|....*....|..
gi 398365871 193 PDKEPGTVFHVQQLGFTLNDRVIRPAKVGIVK 224
Cdd:PRK14145 165 EGKQPNEIIEVFQKGYYLKDKVIRPSLVKVAK 196
PRK14143 PRK14143
heat shock protein GrpE; Provisional
 47-227 6.15e-17

heat shock protein GrpE; Provisional


Pssm-ID: 237624 [Multi-domain]  Cd Length: 238  Bit Score: 76.69  E-value: 6.15e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  47 EAKSEESKENNEDLTEEQSEIKKLESQLSAKTKEASELKDRLLRSVADFRNLQQVTKKDiqkAKDFALQ---KFAKDLLE 123
Cdd:PRK14143  49 ESSPDSGSAASETAADNAARLAQLEQELESLKQELEELNSQYMRIAADFDNFRKRTSRE---QEDLRLQlkcNTLSEILP 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871 124 SVDNFGHALNAFK-----EEDLQKSkeisdlYTGV-RMTRDVfentLRKHGIEKLDPLGEPFDPNKHEATFELPQPDKEP 197
Cdd:PRK14143 126 VVDNFERARQQLKpegeeAQALHRS------YQGLyKQLVDV----LKRLGVSPMRVVGQEFDPNLHEAVLREPSDEHPE 195

                        170       180       190
                 ....*....|....*....|....*....|..
gi 398365871 198 GTVFHVQQLGFTLNDRVIRPA--KVGIVKGEE 227
Cdd:PRK14143 196 DVVLEELQRGYHLGGRVLRHAmvKVSMGPGPS 227
PRK14157 PRK14157
heat shock protein GrpE; Provisional
 45-220 6.89e-17

heat shock protein GrpE; Provisional


Pssm-ID: 184543 [Multi-domain]  Cd Length: 227  Bit Score: 76.53  E-value: 6.89e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  45 SDEAKSEESKENNEDLTEEQSEIKKLESQLSAKTKEASELKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLES 124
Cdd:PRK14157  57 APAAAEGEAKAAAEKTGEAQSDSDDTLTPLGQAKKEAAEYLEALQRERAEFINYRNRTQKEQDRFRQHGIIDVLTALLPA 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871 125 VDnfghalnafkeeDLQKSKEISDLYTGVRMTRDVFENTLRKHGIEKLDPLGEPFDPNKHEATFELPQPDKEPGTVFHVQ 204
Cdd:PRK14157 137 LD------------DIDRIREHSEMDDSFKAVAAKIDKAFEKFGVEKFGEKGEDFDPTKHDAILHKPDPDAEKETVDTVV 204

                        170
                 ....*....|....*.
gi 398365871 205 QLGFTLNDRVIRPAKV 220
Cdd:PRK14157 205 EAGYRIGDRVIRAARV 220
PRK14163 PRK14163
heat shock protein GrpE; Provisional
 46-224 3.44e-16

heat shock protein GrpE; Provisional


Pssm-ID: 184546 [Multi-domain]  Cd Length: 214  Bit Score: 74.39  E-value: 3.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  46 DEAKSEESKENNEDLTEEQSEIKKLESQLSAKTKEASELKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLESV 125
Cdd:PRK14163  21 DDAEPKAASEEGAAPAGDAAATAGLTAQLDQVRTALGERTADLQRLQAEYQNYRRRVERDRVTVKEIAVANLLSELLPVL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871 126 DNFGHAlnafkeedlqksKEISDLYTGVRMTRDVFENTLRKHGIEKLDPLGEPFDPNKHEATFELPQPDKEPGTVFHVQQ 205
Cdd:PRK14163 101 DDVGRA------------REHGELVGGFKSVAESLETTVAKLGLQQFGKEGEPFDPTIHEALMHSYAPDVTETTCVAILQ 168

                        170
                 ....*....|....*....
gi 398365871 206 LGFTLNDRVIRPAKVGIVK 224
Cdd:PRK14163 169 PGYRIGERTIRPARVAVAE 187
PRK14156 PRK14156
heat shock protein GrpE; Provisional
 45-220 2.48e-15

heat shock protein GrpE; Provisional


Pssm-ID: 237628 [Multi-domain]  Cd Length: 177  Bit Score: 71.02  E-value: 2.48e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  45 SDEAKSEESKENNEDLTEEQS-----EIKKLESQLSAKTKEASELKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAK 119
Cdd:PRK14156   2 SEEIKNEEVEEEVEATETEETveevvEETPEKSELELANERADEFENKYLRAHAEMQNIQRRANEERQQLQRYRSQDLAK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871 120 DLLESVDNFGHALNAFKEEDlqkskeisDLYTGVRMTRDVFENTLRKHGIEKLDplGEPFDPNKHEATFELPQPDKEPG- 198
Cdd:PRK14156  82 AILPSLDNLERALAVEGLTD--------DVKKGLEMVQESLIQALKEEGVEEVA--VDSFDHNLHMAVQTLPADDEHPAd 151

                        170       180
                 ....*....|....*....|..
gi 398365871 199 TVFHVQQLGFTLNDRVIRPAKV 220
Cdd:PRK14156 152 SIAQVFQKGYKLHERLLRPAMV 173
PRK14164 PRK14164
heat shock protein GrpE; Provisional
 47-222 3.23e-13

heat shock protein GrpE; Provisional


Pssm-ID: 237632 [Multi-domain]  Cd Length: 218  Bit Score: 66.36  E-value: 3.23e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  47 EAKSEESKENNEDLTEEQSEIKKLESQLSAKTKEaselkdrLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLESVD 126
Cdd:PRK14164  59 EADLEDLLDDVDPELADDGEASTVEAQLAERTED-------LQRVTAEYANYRRRTERERQAIIETAKAGVATDLLPILD 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871 127 nfghalnafkeeDLQKSKEISDLYTG-VRMTRDVFENTLRKHGIEKLDPLGEPFDPNKHEATFELPQPD-KEPGTVFhvq 204
Cdd:PRK14164 132 ------------DLDLAEQHGDLNEGpLKAFSDKLTNVLAGLKVEKFGEEGDAFDPEIHEAVQDLSSGDeKVLGTVL--- 196

                        170
                 ....*....|....*...
gi 398365871 205 QLGFTLNDRVIRPAKVGI 222
Cdd:PRK14164 197 RKGYRMGDRVLRTAMVII 214
PRK14142 PRK14142
heat shock protein GrpE; Provisional
 75-223 3.59e-08

heat shock protein GrpE; Provisional


Pssm-ID: 237623  Cd Length: 223  Bit Score: 52.31  E-value: 3.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  75 SAKTKEASELKDRLLRSVADFRNLQQVTKKDIQKAKDFALQKFAKDLLESVDnfghalnafkeeDLQKSKEISDLYTG-V 153
Cdd:PRK14142  43 AHTEDKVAELTADLQRVQADFANYRKRALRDQQAAADRAKASVVSQLLGVLD------------DLERARKHGDLESGpL 110

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 398365871 154 RMTRDVFENTLRKHGIEKLDPLGEPFDPNKHEATFElpQPDKEPGT---VFHVQQLGFTLNDRVIRPAKVGIV 223
Cdd:PRK14142 111 KSVADKLDSALTGLGLVAFGAEGEDFDPVLHEAVQH--EGDGGQGSkpvIGTVMRQGYQLGEQVLRHALVGVV 181
DUF6715 pfam20462
Domain of unknown function (DUF6715); This putative domain is functionally uncharacterized. ...
 43-146 5.42e-04

Domain of unknown function (DUF6715); This putative domain is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are approximately 200 amino acids in length. This domain appears to belong to the NTF2 superfamily.


Pssm-ID: 466611  Cd Length: 192  Bit Score: 39.70  E-value: 5.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871   43 FYSDEAKSEESKENNEDLTEEQSEI-KKLESQLSAKTKEASELKDRLLRSVADfrnlQQVTKKDIQKAKDFALQKFAKDL 121
Cdd:pfam20462  22 FWYTAAKKGNSAENNDDLTEVEKVItKNLEKNYPETPREVVKFYNRIITCFYD----EEYTDDELYELGDQARLLMDDEL 97

                          90       100
                  ....*....|....*....|....*..
gi 398365871  122 LE--SVDNFGHALNAFKEEDLQKSKEI 146
Cdd:pfam20462  98 LEnnSRDDYFKSLKADIEDYHDKSKKI 124
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 47-124 1.24e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 39.43  E-value: 1.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365871  47 EAKSEESKENNEDLTEEQSEIKKLESQLSAKTKEASELKDRLLRSVADFRNLQQ---VTKKDIQKAKDfALQKFAKDLLE 123
Cdd:COG3883   19 QAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAeiaEAEAEIEERRE-ELGERARALYR 97


                 .
gi 398365871 124 S 124
Cdd:COG3883   98 S 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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