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Conserved domains on  [gi|398366329|ref|NP_014992|]
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pyruvate kinase PYK2 [Saccharomyces cerevisiae S288C]

Protein Classification

pyruvate kinase( domain architecture ID 10084586)

pyruvate kinase catalyzes the phosphorylation of pyruvate to form phosphoenolpyruvate and functions in regulating glycolysis

CATH:  2.40.33.10|3.20.20.60|3.40.1380.20
EC:  2.7.1.40
Gene Ontology:  GO:0004743|GO:0006096|GO:0005524|GO:0030955|GO:0000287
PubMed:  31342570
SCOP:  4003255|4002474|4000500

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 20-502 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


:

Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 721.79  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  20 LRRTSIIGTIGPKTNSCEAITALRKAGLNIIRLNFSHGSYEFHQSVIENAVKSEQQFpGRPLAIALDTKGPEIRTGRTLN 99
Cdd:cd00288    1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKT-GGPVAIALDTKGPEIRTGLFKG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 100 DQDLYIPVDHQMIFTTDASfANTSNDKIMYIDYANLTKVIVPGRFIYVDDGILSFKVLQIIDESNLRVQAVNSGYIASHK 179
Cdd:cd00288   80 GKDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKTLVCEVLNGGVLGSRK 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 180 GVNLPNTDVDLPPLSAKDMKDLQFGVRNGIHIVFASFIRTSEDVLSIRKALGSEGQDIKIISKIENQQGLDNFDEILEVT 259
Cdd:cd00288  159 GVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEAS 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 260 DGVMIARGDLGIEILAPEVLAIQKKLIAKCNLAGKPVICATQMLDSMTHNPRPTRAEVSDVGNAVLDGADCVMLSGETAK 339
Cdd:cd00288  239 DGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 340 GDYPVNAVNIMAATALIAESTIAHLALYDDLRDATPKPTSTTETVAAAATAAILEQDGKAIVVLSTTGNTARLLSKYRPS 419
Cdd:cd00288  319 GKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPN 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 420 CPIILVTRHARTARIAHLYRGVFPFLYePKRLDDWGEDVHRRLKFGVEMARSFGMVDNGDTVVSIQGFKGGVGHSNTLRI 499
Cdd:cd00288  399 APIIAVTRNEQTARQLHLYRGVYPVLF-EEPKPGWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGSTNTMRI 477


                 ...
gi 398366329 500 STV 502
Cdd:cd00288  478 LTV 480
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 20-502 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 721.79  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  20 LRRTSIIGTIGPKTNSCEAITALRKAGLNIIRLNFSHGSYEFHQSVIENAVKSEQQFpGRPLAIALDTKGPEIRTGRTLN 99
Cdd:cd00288    1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKT-GGPVAIALDTKGPEIRTGLFKG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 100 DQDLYIPVDHQMIFTTDASfANTSNDKIMYIDYANLTKVIVPGRFIYVDDGILSFKVLQIIDESNLRVQAVNSGYIASHK 179
Cdd:cd00288   80 GKDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKTLVCEVLNGGVLGSRK 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 180 GVNLPNTDVDLPPLSAKDMKDLQFGVRNGIHIVFASFIRTSEDVLSIRKALGSEGQDIKIISKIENQQGLDNFDEILEVT 259
Cdd:cd00288  159 GVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEAS 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 260 DGVMIARGDLGIEILAPEVLAIQKKLIAKCNLAGKPVICATQMLDSMTHNPRPTRAEVSDVGNAVLDGADCVMLSGETAK 339
Cdd:cd00288  239 DGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 340 GDYPVNAVNIMAATALIAESTIAHLALYDDLRDATPKPTSTTETVAAAATAAILEQDGKAIVVLSTTGNTARLLSKYRPS 419
Cdd:cd00288  319 GKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPN 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 420 CPIILVTRHARTARIAHLYRGVFPFLYePKRLDDWGEDVHRRLKFGVEMARSFGMVDNGDTVVSIQGFKGGVGHSNTLRI 499
Cdd:cd00288  399 APIIAVTRNEQTARQLHLYRGVYPVLF-EEPKPGWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGSTNTMRI 477


                 ...
gi 398366329 500 STV 502
Cdd:cd00288  478 LTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 21-499 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 689.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329   21 RRTSIIGTIGPKTNSCEAITALRKAGLNIIRLNFSHGSYEFHQSVIENAVKSEQQFpGRPLAIALDTKGPEIRTGRTLND 100
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKL-GRPVAILLDTKGPEIRTGEIKGG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  101 qDLYIPVDHQMIFTTDASfANTSNDKIMYIDYANLTKVIVPGRFIYVDDGILSFKVLQIIDEsNLRVQAVNSGYIASHKG 180
Cdd:TIGR01064  80 -EVKLKKGDKVIITTDDI-KGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGD-KVICEVLNGGTLKSKKG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  181 VNLPNTDVDLPPLSAKDMKDLQFGVRNGIHIVFASFIRTSEDVLSIRKALGSEG-QDIKIISKIENQQGLDNFDEILEVT 259
Cdd:TIGR01064 157 VNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNIDEIAEAS 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  260 DGVMIARGDLGIEILAPEVLAIQKKLIAKCNLAGKPVICATQMLDSMTHNPRPTRAEVSDVGNAVLDGADCVMLSGETAK 339
Cdd:TIGR01064 237 DGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAK 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  340 GDYPVNAVNIMAATALIAESTIAHLALYDDLRDATPKPTSTTETVAAAATAAILEQDGKAIVVLSTTGNTARLLSKYRPS 419
Cdd:TIGR01064 317 GKYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPN 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  420 CPIILVTRHARTARIAHLYRGVFPFLYepkrlDDWGEDVHRRLKFGVEMARSFGMVDNGDTVVSIQG-FKGGVGHSNTLR 498
Cdd:TIGR01064 397 APIIAVTPNERVARQLALYWGVFPFLV-----DEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEGGTNTIR 471


                  .
gi 398366329  499 I 499
Cdd:TIGR01064 472 V 472
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 20-367 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 562.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329   20 LRRTSIIGTIGPKTNSCEAITALRKAGLNIIRLNFSHGSYEFHQSVIENAVKSEQQFPGRpLAIALDTKGPEIRTGRTLN 99
Cdd:pfam00224   1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGT-VAIALDTKGPEIRTGNTKD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  100 -DQDLYIPVDHQMIFTTDASFANTSNDKIMYIDYANLTKVIVPGRFIYVDDGILSFKVLQIIDESNLRVQAVNSGYIASH 178
Cdd:pfam00224  80 gKKDIELKAGDEMIVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKTLVVEVLNGGVIGSR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  179 KGVNLPNTDVDLPPLSAKDMKDLQFGVRNGIHIVFASFIRTSEDVLSIRKALGSEGQDIKIISKIENQQGLDNFDEILEV 258
Cdd:pfam00224 160 KGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  259 TDGVMIARGDLGIEILAPEVLAIQKKLIAKCNLAGKPVICATQMLDSMTHNPRPTRAEVSDVGNAVLDGADCVMLSGETA 338
Cdd:pfam00224 240 TDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETA 319

                         330       340
                  ....*....|....*....|....*....
gi 398366329  339 KGDYPVNAVNIMAATALIAESTIAHLALY 367
Cdd:pfam00224 320 KGNYPVEAVRMMHEICLEAEKALPHRNLF 348
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 20-502 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 545.78  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  20 LRRTSIIGTIGPKTNSCEAITALRKAGLNIIRLNFSHGSYEFHQSVIENAVKSEQQFpGRPLAIALDTKGPEIRTGRtLN 99
Cdd:COG0469    2 MRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKEL-GRPVAILLDLQGPKIRTGK-FK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 100 DQDLYIPVDHQMIFTTDAsfaNTSNDKIMYIDYANLTKVIVPGRFIYVDDGILSFKVLQIiDESNLRVQAVNSGYIASHK 179
Cdd:COG0469   80 EGPVELKKGDTFTLTTDD---VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEV-EGDEVVCEVVNGGVLSSRK 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 180 GVNLPNTDVDLPPLSAKDMKDLQFGVRNGIHIVFASFIRTSEDVLSIRKALGSEGQDIKIISKIENQQGLDNFDEILEVT 259
Cdd:COG0469  156 GVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEAS 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 260 DGVMIARGDLGIEILAPEVLAIQKKLIAKCNLAGKPVICATQMLDSMTHNPRPTRAEVSDVGNAVLDGADCVMLSGETAK 339
Cdd:COG0469  236 DGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAV 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 340 GDYPVNAVNIMAATALIAEStiaHLALYDDLRDATPKPTSTTETVAAAATAAILEQ-DGKAIVVLSTTGNTARLLSKYRP 418
Cdd:COG0469  316 GKYPVEAVETMARIAEEAEK---SLDYRRILDRLRDEPERTITDAIARAAVELAEDlGAKAIVAFTESGSTARRISRYRP 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 419 SCPIILVTRHARTARIAHLYRGVFPFLYEP-KRLDDWGEDVhrrlkfgVEMARSFGMVDNGDTVVSIQG-FKGGVGHSNT 496
Cdd:COG0469  393 KVPILALTPNERTARRLALVWGVYPVLVDDvESTDEMIEEA-------VEALLEEGLVKPGDLVVITAGvPVGVPGTTNT 465


                 ....*.
gi 398366329 497 LRISTV 502
Cdd:COG0469  466 LKVHRV 471
PRK05826 PRK05826
pyruvate kinase; Provisional
 20-486 5.82e-169

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 485.04  E-value: 5.82e-169
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  20 LRRTSIIGTIGPKTNSCEAITALRKAGLNIIRLNFSHGSYEFHQSVIENaVKSEQQFPGRPLAIALDTKGPEIRTGRTLN 99
Cdd:PRK05826   3 LRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAAL-VREIAAKLGRPVAILLDLKGPKIRVGKFKE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 100 DQdLYIPVDHQMIFTTDASFANTSNdkIMYIDYANLTKVIVPGRFIYVDDGILSFKVLQIiDESNLRVQAVNSGYIASHK 179
Cdd:PRK05826  82 GK-ITLKTGDKFTLDTDQKEEGDKE--RVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEV-DGDEVETEVKNGGPLSNNK 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 180 GVNLPNTDVDLPPLSAKDMKDLQFGVRNGIHIVFASFIRTSEDVLSIRKALGSEG-QDIKIISKIENQQGLDNFDEILEV 258
Cdd:PRK05826 158 GINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGcPHAKIIAKIERAEAVDNIDEIIEA 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 259 TDGVMIARGDLGIEILAPEVLAIQKKLIAKCNLAGKPVICATQMLDSMTHNPRPTRAEVSDVGNAVLDGADCVMLSGETA 338
Cdd:PRK05826 238 SDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETA 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 339 KGDYPVNAVNIMAATALIAEsTIAHLALYDDLRDATPKPTSTTETVAAAATAAILeQDGKAIVVLSTTGNTARLLSKYRP 418
Cdd:PRK05826 318 AGKYPVEAVEAMARICKGAE-KEFSINLSKHRLDRQFDRIDEAIAMSAMYAANHL-KGVKAIVALTESGRTARLISRFRP 395

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 398366329 419 SCPIILVTRHARTARIAHLYRGVFPFLY-EPKRLDDWGEDVhrrlkfgVEMARSFGMVDNGDTVVSIQG 486
Cdd:PRK05826 396 GAPIFAVTRDEKTQRRLALYRGVYPVLFdSAADTDDAAEEA-------LRLLLEKGLVESGDLVVVTSG 457
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 20-502 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 721.79  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  20 LRRTSIIGTIGPKTNSCEAITALRKAGLNIIRLNFSHGSYEFHQSVIENAVKSEQQFpGRPLAIALDTKGPEIRTGRTLN 99
Cdd:cd00288    1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKT-GGPVAIALDTKGPEIRTGLFKG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 100 DQDLYIPVDHQMIFTTDASfANTSNDKIMYIDYANLTKVIVPGRFIYVDDGILSFKVLQIIDESNLRVQAVNSGYIASHK 179
Cdd:cd00288   80 GKDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDKTLVCEVLNGGVLGSRK 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 180 GVNLPNTDVDLPPLSAKDMKDLQFGVRNGIHIVFASFIRTSEDVLSIRKALGSEGQDIKIISKIENQQGLDNFDEILEVT 259
Cdd:cd00288  159 GVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFDEILEAS 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 260 DGVMIARGDLGIEILAPEVLAIQKKLIAKCNLAGKPVICATQMLDSMTHNPRPTRAEVSDVGNAVLDGADCVMLSGETAK 339
Cdd:cd00288  239 DGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETAK 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 340 GDYPVNAVNIMAATALIAESTIAHLALYDDLRDATPKPTSTTETVAAAATAAILEQDGKAIVVLSTTGNTARLLSKYRPS 419
Cdd:cd00288  319 GKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARLVSKYRPN 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 420 CPIILVTRHARTARIAHLYRGVFPFLYePKRLDDWGEDVHRRLKFGVEMARSFGMVDNGDTVVSIQGFKGGVGHSNTLRI 499
Cdd:cd00288  399 APIIAVTRNEQTARQLHLYRGVYPVLF-EEPKPGWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSGSTNTMRI 477


                 ...
gi 398366329 500 STV 502
Cdd:cd00288  478 LTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 21-499 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 689.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329   21 RRTSIIGTIGPKTNSCEAITALRKAGLNIIRLNFSHGSYEFHQSVIENAVKSEQQFpGRPLAIALDTKGPEIRTGRTLND 100
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKL-GRPVAILLDTKGPEIRTGEIKGG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  101 qDLYIPVDHQMIFTTDASfANTSNDKIMYIDYANLTKVIVPGRFIYVDDGILSFKVLQIIDEsNLRVQAVNSGYIASHKG 180
Cdd:TIGR01064  80 -EVKLKKGDKVIITTDDI-KGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGD-KVICEVLNGGTLKSKKG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  181 VNLPNTDVDLPPLSAKDMKDLQFGVRNGIHIVFASFIRTSEDVLSIRKALGSEG-QDIKIISKIENQQGLDNFDEILEVT 259
Cdd:TIGR01064 157 VNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNIDEIAEAS 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  260 DGVMIARGDLGIEILAPEVLAIQKKLIAKCNLAGKPVICATQMLDSMTHNPRPTRAEVSDVGNAVLDGADCVMLSGETAK 339
Cdd:TIGR01064 237 DGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAK 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  340 GDYPVNAVNIMAATALIAESTIAHLALYDDLRDATPKPTSTTETVAAAATAAILEQDGKAIVVLSTTGNTARLLSKYRPS 419
Cdd:TIGR01064 317 GKYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLLSKYRPN 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  420 CPIILVTRHARTARIAHLYRGVFPFLYepkrlDDWGEDVHRRLKFGVEMARSFGMVDNGDTVVSIQG-FKGGVGHSNTLR 498
Cdd:TIGR01064 397 APIIAVTPNERVARQLALYWGVFPFLV-----DEEPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEGGTNTIR 471


                  .
gi 398366329  499 I 499
Cdd:TIGR01064 472 V 472
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 20-367 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 562.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329   20 LRRTSIIGTIGPKTNSCEAITALRKAGLNIIRLNFSHGSYEFHQSVIENAVKSEQQFPGRpLAIALDTKGPEIRTGRTLN 99
Cdd:pfam00224   1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGT-VAIALDTKGPEIRTGNTKD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  100 -DQDLYIPVDHQMIFTTDASFANTSNDKIMYIDYANLTKVIVPGRFIYVDDGILSFKVLQIIDESNLRVQAVNSGYIASH 178
Cdd:pfam00224  80 gKKDIELKAGDEMIVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKTLVVEVLNGGVIGSR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  179 KGVNLPNTDVDLPPLSAKDMKDLQFGVRNGIHIVFASFIRTSEDVLSIRKALGSEGQDIKIISKIENQQGLDNFDEILEV 258
Cdd:pfam00224 160 KGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNFDEILEA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  259 TDGVMIARGDLGIEILAPEVLAIQKKLIAKCNLAGKPVICATQMLDSMTHNPRPTRAEVSDVGNAVLDGADCVMLSGETA 338
Cdd:pfam00224 240 TDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETA 319

                         330       340
                  ....*....|....*....|....*....
gi 398366329  339 KGDYPVNAVNIMAATALIAESTIAHLALY 367
Cdd:pfam00224 320 KGNYPVEAVRMMHEICLEAEKALPHRNLF 348
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 20-502 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 545.78  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  20 LRRTSIIGTIGPKTNSCEAITALRKAGLNIIRLNFSHGSYEFHQSVIENAVKSEQQFpGRPLAIALDTKGPEIRTGRtLN 99
Cdd:COG0469    2 MRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKEL-GRPVAILLDLQGPKIRTGK-FK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 100 DQDLYIPVDHQMIFTTDAsfaNTSNDKIMYIDYANLTKVIVPGRFIYVDDGILSFKVLQIiDESNLRVQAVNSGYIASHK 179
Cdd:COG0469   80 EGPVELKKGDTFTLTTDD---VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEV-EGDEVVCEVVNGGVLSSRK 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 180 GVNLPNTDVDLPPLSAKDMKDLQFGVRNGIHIVFASFIRTSEDVLSIRKALGSEGQDIKIISKIENQQGLDNFDEILEVT 259
Cdd:COG0469  156 GVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDEIIEAS 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 260 DGVMIARGDLGIEILAPEVLAIQKKLIAKCNLAGKPVICATQMLDSMTHNPRPTRAEVSDVGNAVLDGADCVMLSGETAK 339
Cdd:COG0469  236 DGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAV 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 340 GDYPVNAVNIMAATALIAEStiaHLALYDDLRDATPKPTSTTETVAAAATAAILEQ-DGKAIVVLSTTGNTARLLSKYRP 418
Cdd:COG0469  316 GKYPVEAVETMARIAEEAEK---SLDYRRILDRLRDEPERTITDAIARAAVELAEDlGAKAIVAFTESGSTARRISRYRP 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 419 SCPIILVTRHARTARIAHLYRGVFPFLYEP-KRLDDWGEDVhrrlkfgVEMARSFGMVDNGDTVVSIQG-FKGGVGHSNT 496
Cdd:COG0469  393 KVPILALTPNERTARRLALVWGVYPVLVDDvESTDEMIEEA-------VEALLEEGLVKPGDLVVITAGvPVGVPGTTNT 465


                 ....*.
gi 398366329 497 LRISTV 502
Cdd:COG0469  466 LKVHRV 471
PRK05826 PRK05826
pyruvate kinase; Provisional
 20-486 5.82e-169

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 485.04  E-value: 5.82e-169
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  20 LRRTSIIGTIGPKTNSCEAITALRKAGLNIIRLNFSHGSYEFHQSVIENaVKSEQQFPGRPLAIALDTKGPEIRTGRTLN 99
Cdd:PRK05826   3 LRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAAL-VREIAAKLGRPVAILLDLKGPKIRVGKFKE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 100 DQdLYIPVDHQMIFTTDASFANTSNdkIMYIDYANLTKVIVPGRFIYVDDGILSFKVLQIiDESNLRVQAVNSGYIASHK 179
Cdd:PRK05826  82 GK-ITLKTGDKFTLDTDQKEEGDKE--RVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEV-DGDEVETEVKNGGPLSNNK 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 180 GVNLPNTDVDLPPLSAKDMKDLQFGVRNGIHIVFASFIRTSEDVLSIRKALGSEG-QDIKIISKIENQQGLDNFDEILEV 258
Cdd:PRK05826 158 GINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGcPHAKIIAKIERAEAVDNIDEIIEA 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 259 TDGVMIARGDLGIEILAPEVLAIQKKLIAKCNLAGKPVICATQMLDSMTHNPRPTRAEVSDVGNAVLDGADCVMLSGETA 338
Cdd:PRK05826 238 SDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETA 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 339 KGDYPVNAVNIMAATALIAEsTIAHLALYDDLRDATPKPTSTTETVAAAATAAILeQDGKAIVVLSTTGNTARLLSKYRP 418
Cdd:PRK05826 318 AGKYPVEAVEAMARICKGAE-KEFSINLSKHRLDRQFDRIDEAIAMSAMYAANHL-KGVKAIVALTESGRTARLISRFRP 395

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 398366329 419 SCPIILVTRHARTARIAHLYRGVFPFLY-EPKRLDDWGEDVhrrlkfgVEMARSFGMVDNGDTVVSIQG 486
Cdd:PRK05826 396 GAPIFAVTRDEKTQRRLALYRGVYPVLFdSAADTDDAAEEA-------LRLLLEKGLVESGDLVVVTSG 457
PTZ00300 PTZ00300
pyruvate kinase; Provisional
 47-499 6.04e-168

pyruvate kinase; Provisional


Pssm-ID: 140321 [Multi-domain]  Cd Length: 454  Bit Score: 482.24  E-value: 6.04e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  47 LNIIRLNFSHGSYEFHQSVIENAVKSEQQFpGRPLAIALDTKGPEIRTGRTLNDQDLYIPvDHQMIFTTDASFANTSNDK 126
Cdd:PTZ00300   1 MSVARMNFSHGSHEYHQTTINNVRQAAAEL-GVNIAIALDTKGPEIRTGLFVGGEAVMER-GATCYVTTDPAFADKGTKD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 127 IMYIDYANLTKVIVPGRFIYVDDGILSFKVLQIIDESNLRVQAVNSGYIASHKGVNLPNTDVDLPPLSAKDMKDLQFGVR 206
Cdd:PTZ00300  79 KFYIDYQNLSKVVRPGGYIYIDDGILILHVQSHEDEQTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 207 NGIHIVFASFIRTSEDVLSIRKALGSEGQDIKIISKIENQQGLDNFDEILEVTDGVMIARGDLGIEILAPEVLAIQKKLI 286
Cdd:PTZ00300 159 QGVDMIFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKILI 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 287 AKCNLAGKPVICATQMLDSMTHNPRPTRAEVSDVGNAVLDGADCVMLSGETAKGDYPVNAVNIMAATALIAESTIAHLAL 366
Cdd:PTZ00300 239 SKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAVNEYVF 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 367 YDDLRDATPKPTSTTETVAAAATAAILEQDGKAIVVLSTTGNTARLLSKYRPSCPIILVTRHARTARIAHLYRGVFPFLY 446
Cdd:PTZ00300 319 FNSIKKLQPIPMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVESVFF 398

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 398366329 447 EPKRLDDwGEDVHRRLKFGVEMARSFGMVDNGDTVVSIQGFKGGVGHSNTLRI 499
Cdd:PTZ00300 399 DAERLGH-DEGKEQRVAMGVGFAKSKGYVQSGDLMVVVHADHKVKGYANQTRI 450
PRK09206 PRK09206
pyruvate kinase PykF;
20-499 5.52e-153

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 444.50  E-value: 5.52e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  20 LRRTSIIGTIGPKTNSCEAITALRKAGLNIIRLNFSHGSYEFHQSVIEN--AVKSEQqfpGRPLAIALDTKGPEIRTGRT 97
Cdd:PRK09206   1 MKKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNlrNVMSKT---GKKAAILLDTKGPEIRTMKL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  98 LNDQDLYIPVDHQMIFTTDASFanTSNDKIMYIDYANLTKVIVPGRFIYVDDGILSFKVLQIiDESNLRVQAVNSGYIAS 177
Cdd:PRK09206  78 EGGNDVSLKAGQTFTFTTDKSV--VGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAI-TGNEVICKVLNNGDLGE 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 178 HKGVNLPNTDVDLPPLSAKDMKDLQFGVRNGIHIVFASFIRTSEDVLSIRKALGSE-GQDIKIISKIENQQGLDNFDEIL 256
Cdd:PRK09206 155 NKGVNLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHgGENIQIISKIENQEGLNNFDEIL 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 257 EVTDGVMIARGDLGIEILAPEVLAIQKKLIAKCNLAGKPVICATQMLDSMTHNPRPTRAEVSDVGNAVLDGADCVMLSGE 336
Cdd:PRK09206 235 EASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGE 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 337 TAKGDYPVNAVNIMAAtalIAESTIAHLALYDDLRDATPKptSTTETVAAAATAAILEQ-DGKAIVVLSTTGNTARLLSK 415
Cdd:PRK09206 315 SAKGKYPLEAVSIMAT---ICERTDRVMNSRLESNNDNRK--LRITEAVCRGAVETAEKlDAPLIVVATQGGKSARSVRK 389

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 416 YRPSCPIILVTRHARTARIAHLYRGVFPFLY-EPKRLDDWgedvhrrLKFGVEMARSFGMVDNGDTVVSIQGFKGGVGHS 494
Cdd:PRK09206 390 YFPDATILALTTNEKTARQLVLSKGVVPQLVkEIASTDDF-------YRLGKELALQSGLAQKGDVVVMVSGALVPSGTT 462


                 ....*
gi 398366329 495 NTLRI 499
Cdd:PRK09206 463 NTASV 467
PLN02461 PLN02461
Probable pyruvate kinase
 22-502 6.26e-143

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 420.54  E-value: 6.26e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  22 RTSIIGTIGPKTNSCEAITALRKAGLNIIRLNFSHGSYEFHQSVIENaVKSEQQFPGRPLAIALDTKGPEIRTGrTLNDQ 101
Cdd:PLN02461  22 KTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDN-LRQAMANTGILCAVMLDTKGPEIRTG-FLKDG 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 102 DlyiPV----DHQMIFTTDASFanTSNDKIMYIDYANLTKVIVPGRFIYVDDGILSFKVLQIIDESNL-RVQAVNSGYIA 176
Cdd:PLN02461 100 K---PVqlkqGQEITITTDYSI--KGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLSCDVEAGTvRCRCENSAMLG 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 177 SHKGVNLPNTDVDLPPLSAKDMKD-LQFGVRNGIHIVFASFIRTSEDVLSIRKALGSEGQDIKIISKIENQQGLDNFDEI 255
Cdd:PLN02461 175 ERKNVNLPGVVVDLPTLTEKDKEDiLQWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLISKVENQEGLDNFDDI 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 256 LEVTDGVMIARGDLGIEILAPEVLAIQKKLIAKCNLAGKPVICATQMLDSMTHNPRPTRAEVSDVGNAVLDGADCVMLSG 335
Cdd:PLN02461 255 LAESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSG 334

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 336 ETAKGDYPVNAVNIMAATALIAESTIAHLALYDDLRDATPKPTSTTETVAAAATAAILEQDGKAIVVLSTTGNTARLLSK 415
Cdd:PLN02461 335 ETAAGAYPELAVKTMARICREAEASLDYGALFKEIMRSAPLPMSPLESLASSAVRTANKVKASLIVVLTRGGTTARLVAK 414

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 416 YRPSCPIILVTRHART-------------ARIAHLYRGVFPFLYEPKRLDDWGEDVHRRLKFGVEMARSFGMVDNGDTVV 482
Cdd:PLN02461 415 YRPAVPILSVVVPEITtdsfdwscsdeapARHSLIYRGLIPVLAEGSAKATDSESTEEILEAAIEHAKKKGLCKPGDSVV 494

                        490       500
                 ....*....|....*....|
gi 398366329 483 SIQgfkgGVGHSNTLRISTV 502
Cdd:PLN02461 495 ALH----RIGGASVIKILTV 510
PTZ00066 PTZ00066
pyruvate kinase; Provisional
 21-502 1.09e-141

pyruvate kinase; Provisional


Pssm-ID: 173361 [Multi-domain]  Cd Length: 513  Bit Score: 417.24  E-value: 1.09e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  21 RRTSIIGTIGPKTNSCEAITALRKAGLNIIRLNFSHGSYEFHQSVIENAVKSEQQFPGRPLAIALDTKGPEIRTGRTLND 100
Cdd:PTZ00066  38 KKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVREAAKARPNANLGILLDTKGPEIRTGFLKNH 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 101 QDLYIPVDHQMIFTTDASFanTSNDKIMYIDYANLTKVIVPGRFIYVDDGILSFKVLQIIDEsNLRVQAVNSGYIASHKG 180
Cdd:PTZ00066 118 KPITLKEGQTLKITTDYTF--LGDETCISCSYKKLPQSVKVGNIILIADGSLSCKVLEVHDD-YIITKVLNNATIGERKN 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 181 VNLPNTDVDLPPLSAKDMKD-LQFGVRNGIHIVFASFIRTSEDVLSIRKALGSEGQDIKIISKIENQQGLDNFDEILEVT 259
Cdd:PTZ00066 195 MNLPGVKVELPVIGEKDKNDiLNFAIPMGCDFIALSFVQSADDVRLCRQLLGERGRHIKIIPKIENIEGLINFDEILAES 274

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 260 DGVMIARGDLGIEILAPEVLAIQKKLIAKCNLAGKPVICATQMLDSMTHNPRPTRAEVSDVGNAVLDGADCVMLSGETAK 339
Cdd:PTZ00066 275 DGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVMLSGETAN 354

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 340 GDYPVNAVNIMAATALIAESTIAHLALYDDLRDATPKPTSTTETVAAAATAAILEQDGKAIVVLSTTGNTARLLSKYRPS 419
Cdd:PTZ00066 355 GKFPVEAVNIMAKICFEAETCIDYRVLYHAIHLAVPTPVSVQEAVARSAVETAEDINAKLIIALTETGNTARLISKYRPS 434

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 420 CPIILVTRHARTARIAHLYRGVFPflYEPKRLDDWGEDVHRrlkfGVEMARSFGMVDNGDTVVSIQGFKGGV-GHSNTLR 498
Cdd:PTZ00066 435 CTILALSASPSVVKSLSVARGVTT--YVVNSFQGTDVVIRN----AIALAKERGLVESGDSAIAVHGVKEEVaGSSNLMK 508


                 ....
gi 398366329 499 ISTV 502
Cdd:PTZ00066 509 VVKI 512
PRK06354 PRK06354
pyruvate kinase; Provisional
 21-503 2.00e-139

pyruvate kinase; Provisional


Pssm-ID: 235784 [Multi-domain]  Cd Length: 590  Bit Score: 414.32  E-value: 2.00e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  21 RRTSIIGTIGPKTNSCEAITALRKAGLNIIRLNFSHGSYEFHQSVIENAVKSEQQFpGRPLAIALDTKGPEIRTGR---- 96
Cdd:PRK06354   8 RRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKL-GKTVGILQDLQGPKIRLGRfedg 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  97 --TLNDQDLYIPVDHQMIFTTDasfantsndkIMYIDYANLTKVIVPGRFIYVDDGILSFKVLQI-IDESNLRVQAVNSG 173
Cdd:PRK06354  87 piELKTGDEFILTSREVLGTQE----------KFSVTYDGLADEVPVGSRILLDDGLIELEVEEVdKADGELHCKVLVGG 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 174 YIASHKGVNLPNTDVDLPPLSAKDMKDLQFGVRNGIHIVFASFIRTSEDVLSIRKALGSE-GQDIKIISKIENQQGLDNF 252
Cdd:PRK06354 157 VLSNKKGVNFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHnGKHIPIIAKIEKQEAIDNI 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 253 DEILEVTDGVMIARGDLGIEILAPEVLAIQKKLIAKCNLAGKPVICATQMLDSMTHNPRPTRAEVSDVGNAVLDGADCVM 332
Cdd:PRK06354 237 DAILELCDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAVM 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 333 LSGETAKGDYPVNAVNIMAATALIAESTIAhlalYDDLRDATPKPTSTTETVAAAATAAILEQ-DGKAIVVLSTTGNTAR 411
Cdd:PRK06354 317 LSNETAAGDYPVEAVQTMATIAVRIEKDLP----YRDILSKRPEFTTTITNAISQAVSHIALQlDAAAIVTLTKSGATAR 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 412 LLSKYRPSCPIILVTRHARTARIAHLYRGVFPFLYEPKRLDDwgedvhRRLKFGVEMARSFGMVDNGDTVVSIQGFKGGV 491
Cdd:PRK06354 393 NVSKYRPKTPILAVTPNESVARRLQLVWGVTPLLVLDAPSTD------ETFDAAINVAQESGLLKQGDLVVITAGTLVGE 466

                        490
                 ....*....|...
gi 398366329 492 -GHSNTLRISTVG 503
Cdd:PRK06354 467 sGSTDLMKVHVVG 479
PRK06247 PRK06247
pyruvate kinase; Provisional
 20-505 4.90e-115

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 347.68  E-value: 4.90e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  20 LRRTSIIGTIGPKTNSCEAITALRKAGLNIIRLNFSHGSYEFHQSVIENAVKSEQQFpGRPLAIALDTKGPEIRTGR--- 96
Cdd:PRK06247   4 NRRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDET-GRPIGILADLQGPKLRLGRfad 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  97 -----------TLNDQDlyIPVDHQMIFTTdasfantsndkimyidYANLTKVIVPGRFIYVDDGILSFKVLQIiDESNL 165
Cdd:PRK06247  83 gkvqlangqtfRLDVDD--APGDHDRVSLP----------------HPEIAAALKPGDRLLVDDGKVRLVVEAC-DGDDV 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 166 RVQAVNSGYIASHKGVNLPNTDVDLPPLSAKDMKDLQFGVRNGIHIVFASFIRTSEDVLSIRKALGSEgqdIKIISKIEN 245
Cdd:PRK06247 144 VCRVVEGGPVSDRKGVSLPGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKIIGGR---VPVMAKIEK 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 246 QQGLDNFDEILEVTDGVMIARGDLGIEILAPEVLAIQKKLIAKCNLAGKPVICATQMLDSMTHNPRPTRAEVSDVGNAVL 325
Cdd:PRK06247 221 PQAIDRLEAIVEASDAIMVARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVL 300

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 326 DGADCVMLSGETAKGDYPVNAVNIMAATALIAESTIAhlalYDDLRDAT-PKPTSTTETVAAAATAAILEQ-DGKAIVVL 403
Cdd:PRK06247 301 DGADAVMLSAETASGKYPVEAVRTMARIIRQVERDPT----YPPLIHAQrPQPEATKRDAISYAARDIAERlDLAALVAY 376

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 404 STTGNTARLLSKYRPSCPIILVTRHARTARIAHLYRGVFPFLYEpkRLDDWGEDVHRRLkfgvEMARSFGMVDNGDTVVS 483
Cdd:PRK06247 377 TSSGDTALRAARERPPLPILALTPNPETARRLALTWGVHCVVVD--DARDTDDMVRRAD----RIALAEGFYKRGDRVVI 450

                        490       500
                 ....*....|....*....|...
gi 398366329 484 IQGFK-GGVGHSNTLRISTVGQE 505
Cdd:PRK06247 451 VAGVPpGTPGSTNMLRIAYIGED 473
PLN02765 PLN02765
pyruvate kinase
 23-503 2.60e-96

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 301.20  E-value: 2.60e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  23 TSIIGTIGPKTNSCEAITALRKAGLNIIRLNFSHGSYEFHQSVIEN---AVKSEQqfpgRPLAIALDTKGPEIRTgrtLN 99
Cdd:PLN02765  30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENlkiAVKNTK----KLCAVMLDTVGPELQV---IN 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 100 DQDLYIP--VDHQMIFTTDASFANTSndKIMYIDYANLTKVIVPGRFIYVDD----GILSFKVLqiidesnLRVQAVNSG 173
Cdd:PLN02765 103 KTEKPISlkAGNTVTLTPDQSKEASS--EVLPINFPGLAKAVKPGDTIFVGQylftGSETTSVW-------LEVDEVKGD 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 174 YI-------ASHKGVNLP----NTDVDLPPLSAKDMKDL-QFGVRNGIHIVFASFIRTSEDVLSIRKALGSEG-QDIKII 240
Cdd:PLN02765 174 DVvctvknsATLAGSLFTlhvsQVRIDLPTLSEKDKEVIsTWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGlSQTQIF 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 241 SKIENQQGLDNFDEILEVTDGVMIARGDLGIEILAPEVLAIQKKLIAKCNLAGKPVIcATQMLDSMTHNPRPTRAEVSDV 320
Cdd:PLN02765 254 AKIENVEGLTHFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAV-VTRVVDSMTDNLRPTRAEATDV 332

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 321 GNAVLDGADCVMLSGETAKGDYPVNAVNIMAATALIAESTIAHLALYDDLRDATPKPTSTTETVAAAATAAILEQDGKAI 400
Cdd:PLN02765 333 ANAVLDGADAILLGAETLRGLYPVETISTVGRICAEAEKVFNQDLYFKKTVKYVGEPMSHLESIASSAVRAAIKVKASVI 412

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 401 VVLSTTGNTARLLSKYRPSCPIILV------TRH-------ARTARIAHLYRGVFPFLYEPKRLDDWGEDVHRR-LKFGV 466
Cdd:PLN02765 413 IVFTSSGRAARLIAKYRPTMPVLSVviprlkTNQlkwsftgAFQARQCLIVRGLFPMLADPRHSAESTSATNESvLKVAL 492

                        490       500       510
                 ....*....|....*....|....*....|....*..
gi 398366329 467 EMARSFGMVDNGDTVVSIQgfkgGVGHSNTLRISTVG 503
Cdd:PLN02765 493 DHGKAAGVIKSHDRVVVCQ----KVGDSSVVKIIELD 525
PLN02623 PLN02623
pyruvate kinase
 1-485 2.01e-90

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 287.59  E-value: 2.01e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329   1 MPESRLQRLANLKIGTPQQLRRTSIIGTIGPKTNSCEAITALRKAGLNIIRLNFSHGSYEFHQSVIENAVKSEQQFPGRP 80
Cdd:PLN02623  90 LEIQQLGETAVGMWSKPSVRRKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEYNAQSKDNV 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  81 LAIALDTKGPEIRTGRTlnDQDLYIPVDHQMIFTTDASFANTSNDKIMYIDYANLTKVivpGRFIYVDDGILSFKVLQII 160
Cdd:PLN02623 170 IAIMLDTKGPEVRSGDL--PQPIMLEEGQEFTFTIKRGVSTEDCVSVNYDDFVNDVEV---GDMLLVDGGMMSLAVKSKT 244

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 161 DESnLRVQAVNSGYIASHKGVNLPNTDVDLPPLSAKDMKDLQFGVRNGIHIVFASFIRTSEDVLSIRKALGSEGQDIKII 240
Cdd:PLN02623 245 SDS-VKCEVVDGGELKSRRHLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNADIHVI 323

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 241 SKIENQQGLDNFDEILEVTDGVMIARGDLGIEILAPEVLAIQKKLIAKCNLAGKPVICATQMLDSMTHNPRPTRAEVSDV 320
Cdd:PLN02623 324 VKIESADSIPNLHSIITASDGAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDI 403

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 321 GNAVLDGADCVMLSGETAKGDYPVNAVNIMAATALIAESTIAHLALYDDLRDATPKPTSTTETVAAAATAAILeqdGKAI 400
Cdd:PLN02623 404 AIAVREGADAVMLSGETAHGKFPLKAVKVMHTVALRTEATLPEGTTPPNLGQAFKNHMSEMFAFHATMMANTL---GTSI 480

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 401 VVLSTTGNTARLLSKYRPSCPIILVTRHARTARIAHLYRGVFPFLYEPKrlDDWGEDVHRRLKfgveMARSFGMVDNGDT 480
Cdd:PLN02623 481 IVFTRTGFMAILLSHYRPSGTIFAFTNEKRIQQRLALYQGVCPIYMQFS--DDAEETFARALS----LLLNKGMVKEGEE 554


                 ....*
gi 398366329 481 VVSIQ 485
Cdd:PLN02623 555 VALVQ 559
PLN02762 PLN02762
pyruvate kinase complex alpha subunit
 10-484 1.04e-78

pyruvate kinase complex alpha subunit


Pssm-ID: 215407 [Multi-domain]  Cd Length: 509  Bit Score: 255.05  E-value: 1.04e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  10 ANLKIGTPQQLRRTSIIGTIGPKTNSCEAITALRKAGLNIIRLNFSHGSYEFHQSVIENaVKSEQQFPGRPLAIALDTKG 89
Cdd:PLN02762  14 AELRENGFRSTRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRR-VRRLNEEKGFAVAVMMDTEG 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  90 PEIRTGrtlndqDLYIPV-----DHQMIFTTDASFANTSNDKIMYIDYANLTKVIVPGRFIYVDDGILSFKVLQIIDeSN 164
Cdd:PLN02762  93 SEIHMG------DLGGASsakaeDGEEWTFTVRKFDGSRPEFTIQVNYDGFAEDVKVGDELVVDGGMVRFEVIEKIG-PD 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 165 LRVQAVNSGYIASHKGVNL-------PNTDVDLPPLSAKDMKDLQFGVRNGIHIVFASFIRTSEDVLSIRKALG--SEGQ 235
Cdd:PLN02762 166 VKCKCTDPGLLLPRANLTFwrdgslvRERNAMLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAarSRDS 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 236 DIKIISKIENQQGLDNFDEILEVTDGVMIARGDLGIEILAPEVLAIQKKLIAKCNLAGKPVICATQMLDSMTHNPRPTRA 315
Cdd:PLN02762 246 DIGVIAKIESLDSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRA 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 316 EVSDVGNAVLDGADCVMLSGETAKGDYPVNAVNIMAATALIAES----TIAHLALY-DDLRDATPKPTSTTETVAAAATA 390
Cdd:PLN02762 326 EVADVSEAVRQRADALMLSGESAMGLYPEKALSVLRSVSLRMELwsreEKRHEALElPQLSSSLSDRISEEICNSAAKMA 405

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 391 AILEQDgkAIVVLSTTGNTARLLSKYRPSCPIILVTRHARTARIAHLYRGVFPFLYepkrldDWGEDVHRRLKFGVEMAR 470
Cdd:PLN02762 406 NNLGVD--AIFVYTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRL------DFSDDMESNLNKTFSLLK 477

                        490
                 ....*....|....
gi 398366329 471 SFGMVDNGDTVVSI 484
Cdd:PLN02762 478 ARGMIKSGDLVIAV 491
PRK06739 PRK06739
pyruvate kinase; Validated
 26-358 7.18e-71

pyruvate kinase; Validated


Pssm-ID: 180676 [Multi-domain]  Cd Length: 352  Bit Score: 229.83  E-value: 7.18e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  26 IGTIGPKTNSCEAITALRKAGLNIIRLNFSHGSYEFHQSVIEnAVKSEQQfpgrPLAIALDTKGPEIRTGRTLNDQDLYI 105
Cdd:PRK06739   6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIR-LVKSLDD----SIKILGDVQGPKIRLGEIKGEQITLQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 106 PVDHQMIFTTDAsfanTSNDKIMYIDYANLTKVIVPGRFIYVDDGILSFkVLQIIDESNLRVQAVNSGYIASHKGVNLPN 185
Cdd:PRK06739  81 AGDSFILHTQPV----TGSSTEASVDYEGIANDVKVGSRILMNDGEVEL-IVEKVSTDKIETKVKTGGNISSHKGVNLPG 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 186 TDVDLPPLSAKDMKDLQFGVRNGIHIVFASFIRTSEDVLSIRKALGSEGQDI-KIISKIENQQGLDNFDEILEVTDGVMI 264
Cdd:PRK06739 156 AIVRLPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSpNLIAKIETMEAIENFQDICKEADGIMI 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 265 ARGDLGIEILAPEVLAIQKKLIAKCNLAGKPVICATQMLDSMTHNPRPTRAEVSDVGNAVLDGADCVMLSGETAKGDYPV 344
Cdd:PRK06739 236 ARGDLGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPI 315

                        330
                 ....*....|....
gi 398366329 345 NAVNIMAATALIAE 358
Cdd:PRK06739 316 ESVSTLRLVSEFAE 329
PRK08187 PRK08187
pyruvate kinase; Validated
 3-350 5.05e-45

pyruvate kinase; Validated


Pssm-ID: 236178  Cd Length: 493  Bit Score: 164.80  E-value: 5.05e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329   3 ESRLQRLANLKIGTPQQLRRTSIIGTIGPktnscEA------ITALRKAGLNIIRLNFSHGSYEFHQSVIENAVKSEQQf 76
Cdd:PRK08187 115 ERLLAAHTEELFGPRPAARRTRIMVTLPS-----EAaddpdfVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAERA- 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  77 PGRPLAIALDTKGPEIRTGrtlndqDLYIPVDHQMIFTTD-----ASFANTSNDKIMYIDYANLTKVIV---PGRFIYVD 148
Cdd:PRK08187 189 TGRRCKILMDLAGPKIRTG------AVAGPLGKTRLYTGDrlalvAQGPPRRIDEEHFQVTCTLPEILArlaVGARVWID 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 149 DGILSFKVLQII-DESNLRVQAVNSG--YIASHKGVNLPNTDVDLPPLSAKDMKDLQFGVRNGiHIVFASFIRTSEDVLS 225
Cdd:PRK08187 263 DGKLGARVERVGpGGALLEVTHARPKglKLKPEKGLNFPDTALDLPALTEKDRADLDFVARHA-DLVGYSFVQSPGDVEA 341

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 226 IRKALGSEGQD----IKIISKIENQQGLDNFDEIL-----EVTDGVMIARGDLGIEIlAPEVLA-IQKKLIAKCNLAGKP 295
Cdd:PRK08187 342 LQAALAARRPDdwrkLGLVLKIETPRAVANLPELIvqaagRQPFGVMIARGDLAVEI-GFERLAeMQEEILWLCEAAHVP 420

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 398366329 296 VICATQMLDSMTHNPRPTRAEVSDVgnAVLDGADCVMLSgetaKGDYPVNAVNIM 350
Cdd:PRK08187 421 VIWATQVLEGLVKKGLPSRAEMTDA--AMAARAECVMLN----KGPYLVEAVTFL 469
PykA2 COG3848
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
288-503 2.40e-38

Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];


Pssm-ID: 443058  Cd Length: 321  Bit Score: 142.35  E-value: 2.40e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 288 KCNLAGKPVICATQMLDSMTHNPRPTRAEVSDVGNAVLDGADCVMLSGETAKGDYPVNAVNIMAATALIAESTIAHlalY 367
Cdd:COG3848    1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEY---R 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 368 DDLRDATPKPTSTTETVAAAATAAILEQDG-KAIVVLSTTGNTARLLSKYRPSCPIILVTRHARTARIAHLYRGVFPFLY 446
Cdd:COG3848   78 EQRVPRAKESSTTITDAISHAVATTAADLGaAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLV 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 398366329 447 EPKRLDDwgEDVHRRlkfgVEMARSFGMVDNGDTVVSIQG-FKGGVGHSNTLRISTVG 503
Cdd:COG3848  158 EESASTD--EMFAVA----VALALEAGLVKDGDLVVITAGvPVGVSGTTNLLKVHVVG 209
PRK14725 PRK14725
pyruvate kinase; Provisional
 141-349 6.67e-38

pyruvate kinase; Provisional


Pssm-ID: 237804  Cd Length: 608  Bit Score: 146.63  E-value: 6.67e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 141 PGRFIYVDDGilsfKVLQII-----DESNLRV-QAVNSGY-IASHKGVNLPNTDVDLPPLSAKDMKDLQFGVRNGiHIVF 213
Cdd:PRK14725 375 VGERVWFDDG----KIGAVVvkveaDEVELRItHARPGGSkLKAGKGINLPDSHLPLPALTDKDLEDLAFVAKHA-DIVA 449

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329 214 ASFIRTSEDVLSIRKALGSEG-QDIKIISKIENQQGLDNFDEILEVT-----DGVMIARGDLGIEiLAPEVLA-IQKKLI 286
Cdd:PRK14725 450 LSFVRSPEDVRLLLDALEKLGaDDLGVVLKIETRRAFENLPRILLEAmrhprFGVMIARGDLAVE-VGFERLAeVQEEIL 528

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 398366329 287 AKCNLAGKPVICATQMLDSMTHNPRPTRAEVSDVGNAVLdgADCVMLSgetaKGDYPVNAVNI 349
Cdd:PRK14725 529 WLCEAAHVPVIWATQVLESLAKKGLPSRAEITDAAMALR--AECVMLN----KGPHIVEAVRV 585
PK_C pfam02887
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
 394-499 1.01e-33

Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.


Pssm-ID: 460738 [Multi-domain]  Cd Length: 114  Bit Score: 123.36  E-value: 1.01e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  394 EQDGKAIVVLSTTGNTARLLSKYRPSCPIILVTRHARTARIAHLYRGVFPFLYEPKRLDDwgedvhRRLKFGVEMARSFG 473
Cdd:pfam02887  13 ELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEAETTD------EMLRRAVKVAKEAG 86

                          90       100
                  ....*....|....*....|....*..
gi 398366329  474 MVDNGDTVVSIQGFKGGV-GHSNTLRI 499
Cdd:pfam02887  87 LVKKGDLVVITAGVPFGVsGTTNTLKV 113
HpcH COG3836
2-keto-3-deoxy-L-rhamnonate aldolase RhmA [Carbohydrate transport and metabolism];
243-296 1.16e-06

2-keto-3-deoxy-L-rhamnonate aldolase RhmA [Carbohydrate transport and metabolism];


Pssm-ID: 443047 [Multi-domain]  Cd Length: 237  Bit Score: 49.73  E-value: 1.16e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 398366329 243 IENQQGLDNFDEILEVT--DGVMIARGDLGI------EILAPEVLAIQKKLIAKCNLAGKPV 296
Cdd:COG3836  148 IETAEAVENLDEIAAVPgvDGVFIGPADLSAslghpgQPDHPEVQAAIERVIAAARAAGKPA 209
PRK10558 PRK10558
alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional
 236-296 3.03e-04

alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional


Pssm-ID: 182547  Cd Length: 256  Bit Score: 42.42  E-value: 3.03e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 398366329 236 DIKIISKIENQQGLDNFDEI--LEVTDGVMIARGDL--GIEILA----PEVLAIQKKLIAKCNLAGKPV 296
Cdd:PRK10558 145 NITVLVQIESQQGVDNVDAIaaTEGVDGIFVGPSDLaaALGHLGnashPDVQKAIQHIFARAKAHGKPS 213
HpcH_HpaI pfam03328
HpcH/HpaI aldolase/citrate lyase family; This family includes 2,4-dihydroxyhept-2-ene-1, ...
 188-293 8.96e-04

HpcH/HpaI aldolase/citrate lyase family; This family includes 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase and 4-hydroxy-2-oxovalerate aldolase.


Pssm-ID: 427247 [Multi-domain]  Cd Length: 221  Bit Score: 40.80  E-value: 8.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366329  188 VDLPPLSAKDMKDLQFGVRNGIHIVFASFIRTSEDVLSIRKAL-------GSEGQDIKIISKIENQQGLDNFDEILEV-- 258
Cdd:pfam03328  64 VRVNSLDSPFGKQDLAVLDLGAQVVLVPKVETAEDARAAVSAIryppkgiRRANGNTCLLAQIESALGVLNADEIAAVeg 143

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 398366329  259 TDGVMIARGDLGIEILA------PEVLAIQKKLIAKCNLAG 293
Cdd:pfam03328 144 VDGIFLGAEDLSADLGTlrspggPEVLYARERIVTAARAAG 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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