Iqg1p [Saccharomyces cerevisiae S288C]
Protein Classification
Ras GTPase-activating protein( domain architecture ID 11474206)
Ras GTPase-activating protein accelerates the GTPase activity of Ras
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||||||||||||||||||
| IQG1 | COG5261 | Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and ... |
1-1494 | 0e+00 | ||||||||||||||||||||
Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]; : Pssm-ID: 227586 [Multi-domain] Cd Length: 1054 Bit Score: 1156.18 E-value: 0e+00
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| Name | Accession | Description | Interval | E-value | ||||||||||||||||||||
| IQG1 | COG5261 | Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and ... |
1-1494 | 0e+00 | ||||||||||||||||||||
Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]; Pssm-ID: 227586 [Multi-domain] Cd Length: 1054 Bit Score: 1156.18 E-value: 0e+00
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| RasGAP_IQGAP_related | cd12206 | Ras-GTPase Activating Domain of proteins related to IQGAPs; RasGAP: Ras-GTPase Activating ... |
852-1198 | 4.66e-129 | ||||||||||||||||||||
Ras-GTPase Activating Domain of proteins related to IQGAPs; RasGAP: Ras-GTPase Activating Domain. RasGAP functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a myriad of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGap domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator. Pssm-ID: 213345 [Multi-domain] Cd Length: 359 Bit Score: 404.79 E-value: 4.66e-129
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| RasGAP_C | pfam03836 | RasGAP C-terminus; This domain can be found in the C terminus of the IQGAP family members, ... |
1253-1397 | 4.64e-31 | ||||||||||||||||||||
RasGAP C-terminus; This domain can be found in the C terminus of the IQGAP family members, including human IQGAP1/2/3, S. cerevisiae Iqg1 and S. pombe Rng2. Some members function in cytoskeletal remodelling. Human IQGAP1 is a scaffolding protein that can assemble multi-protein complexes involved in cell-cell interaction, cell adherence, and movement via actin/tubulin-based cytoskeletal reorganization. IQGAP1 is also a regulator of the MAPK and Wnt/beta-catenin signaling pathways.Iqg1 and Rng2 are required for actomyosin ring construction during cytokinesis. Pssm-ID: 461071 Cd Length: 137 Bit Score: 119.19 E-value: 4.64e-31
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| CH | smart00033 | Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ... |
113-213 | 1.34e-13 | ||||||||||||||||||||
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p. Pssm-ID: 214479 [Multi-domain] Cd Length: 101 Bit Score: 68.11 E-value: 1.34e-13
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| 235kDa-fam | TIGR01612 | reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ... |
1013-1362 | 4.36e-03 | ||||||||||||||||||||
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii. Pssm-ID: 130673 [Multi-domain] Cd Length: 2757 Bit Score: 41.96 E-value: 4.36e-03
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| Name | Accession | Description | Interval | E-value | ||||||||||||||||||||
| IQG1 | COG5261 | Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and ... |
1-1494 | 0e+00 | ||||||||||||||||||||
Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]; Pssm-ID: 227586 [Multi-domain] Cd Length: 1054 Bit Score: 1156.18 E-value: 0e+00
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| RasGAP_IQGAP_related | cd12206 | Ras-GTPase Activating Domain of proteins related to IQGAPs; RasGAP: Ras-GTPase Activating ... |
852-1198 | 4.66e-129 | ||||||||||||||||||||
Ras-GTPase Activating Domain of proteins related to IQGAPs; RasGAP: Ras-GTPase Activating Domain. RasGAP functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a myriad of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGap domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator. Pssm-ID: 213345 [Multi-domain] Cd Length: 359 Bit Score: 404.79 E-value: 4.66e-129
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| CH_IQGAP | cd21206 | calponin homology (CH) domain found in the IQ motif containing GTPase activating protein ... |
102-221 | 1.96e-48 | ||||||||||||||||||||
calponin homology (CH) domain found in the IQ motif containing GTPase activating protein family; Members of the IQ motif containing GTPase activating protein (IQGAP) family are associated with the Ras GTP-binding protein and act as essential regulators of cytoskeletal function. There are three known IQGAP family members: IQGAP1, IQGAP2, and IQGAP3. They are multi-domain molecules having a calponin-homology (CH) domain which binds F-actin, IQGAP-specific repeats, a single WW domain, four IQ motifs that mediate interactions with calmodulin, and a RasGAP related domain that binds active Rho family GTPases. IQGAP1 negatively regulates Ras family GTPases by stimulating their intrinsic GTPase activity. It lacks GAP activity. Both IQGAP1 and IQGAP2 specifically bind to Cdc42 and Rac1, but not to RhoA. Despite similarities to part of the sequence of RasGAP, neither IQGAP1 nor IQGAP2 interacts with Ras. IQGAP3 regulates the organization of the cytoskeleton under the regulation of Rac1 and Cdc42 in neuronal cells. The depletion of IQGAP3 is shown to impair neurite or axon outgrowth in neuronal cells with disorganized cytoskeleton. Pssm-ID: 409055 [Multi-domain] Cd Length: 118 Bit Score: 168.17 E-value: 1.96e-48
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| RasGAP_C | pfam03836 | RasGAP C-terminus; This domain can be found in the C terminus of the IQGAP family members, ... |
1253-1397 | 4.64e-31 | ||||||||||||||||||||
RasGAP C-terminus; This domain can be found in the C terminus of the IQGAP family members, including human IQGAP1/2/3, S. cerevisiae Iqg1 and S. pombe Rng2. Some members function in cytoskeletal remodelling. Human IQGAP1 is a scaffolding protein that can assemble multi-protein complexes involved in cell-cell interaction, cell adherence, and movement via actin/tubulin-based cytoskeletal reorganization. IQGAP1 is also a regulator of the MAPK and Wnt/beta-catenin signaling pathways.Iqg1 and Rng2 are required for actomyosin ring construction during cytokinesis. Pssm-ID: 461071 Cd Length: 137 Bit Score: 119.19 E-value: 4.64e-31
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| CH_IQGAP3 | cd21276 | calponin homology (CH) domain found in Ras GTPase-activating-like protein IQGAP3; IQ motif ... |
105-246 | 6.08e-27 | ||||||||||||||||||||
calponin homology (CH) domain found in Ras GTPase-activating-like protein IQGAP3; IQ motif containing GTPase activating protein 3 (IQGAP3) associates with Ras GTP-binding proteins. It regulates the organization of the cytoskeleton under the regulation of Rac1 and Cdc42 in neuronal cells. The depletion of IQGAP3 is shown to impair neurite or axon outgrowth in neuronal cells with disorganized cytoskeleton. It belongs to the IQGAP family, which consists of multi-domain proteins having a calponin-homology (CH) domain which binds F-actin, IQGAP-specific repeats, a single WW domain, four IQ motifs that mediate interactions with calmodulin, and a RasGAP related domain that binds active Rho family GTPases. IQGAP3 contains a single copy of the CH domain at the N-terminus. Pssm-ID: 409125 [Multi-domain] Cd Length: 152 Bit Score: 108.14 E-value: 6.08e-27
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| CH_IQGAP1 | cd21274 | calponin homology (CH) domain found in Ras GTPase-activating-like protein IQGAP1; IQ motif ... |
105-242 | 1.44e-20 | ||||||||||||||||||||
calponin homology (CH) domain found in Ras GTPase-activating-like protein IQGAP1; IQ motif containing GTPase activating protein 1 (IQGAP1), also called p195, is a homodimeric protein that is widely expressed among vertebrate cell types from early embryogenesis. It plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. It belongs to the IQGAP family, which consists of multi-domain proteins having a calponin-homology (CH) domain which binds F-actin, IQGAP-specific repeats, a single WW domain, four IQ motifs that mediate interactions with calmodulin, and a RasGAP related domain that binds active Rho family GTPases. IQGAP1 negatively regulates Ras family GTPases by stimulating their intrinsic GTPase activity. It lacks GAP activity. Both, IQGAP1 and IQGAP2, specifically bind to Cdc42 and Rac1, but not to RhoA. Despite similarities to part of the sequence of RasGAP, neither IQGAP1 nor IQGAP2 interacts with Ras. IQGAP1 contains a single copy of the CH domain at the N-terminus. Pssm-ID: 409123 [Multi-domain] Cd Length: 154 Bit Score: 90.05 E-value: 1.44e-20
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| CH_SF | cd00014 | calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ... |
111-215 | 4.83e-20 | ||||||||||||||||||||
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav). Pssm-ID: 409031 [Multi-domain] Cd Length: 103 Bit Score: 86.62 E-value: 4.83e-20
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| CH_IQGAP2 | cd21275 | calponin homology (CH) domain found in Ras GTPase-activating-like protein IQGAP2; IQ motif ... |
105-213 | 1.21e-19 | ||||||||||||||||||||
calponin homology (CH) domain found in Ras GTPase-activating-like protein IQGAP2; IQ motif containing GTPase activating protein 2 (IQGAP2) is a member of the IQGAP family, which consists of multi-domain proteins having a calponin-homology (CH) domain which binds F-actin, IQGAP-specific repeats, a single WW domain, four IQ motifs that mediate interactions with calmodulin, and a RasGAP related domain that binds active Rho family GTPases. IQGAP2 binds to activated Cdc42 and Rac1 but does not seem to stimulate their GTPase activity. It associates with calmodulin. IQGAP2 contains a single copy of the CH domain at the N-terminus. Pssm-ID: 409124 [Multi-domain] Cd Length: 156 Bit Score: 87.38 E-value: 1.21e-19
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| CH_dMP20-like | cd21207 | calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 ... |
113-213 | 3.13e-17 | ||||||||||||||||||||
calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 (dMP20) and similar domains; This subfamily contains Drosophila melanogaster muscle-specific protein 20 (dMP20), Echinococcus granulosus myophilin, Dictyostelium discoideum Rac guanine nucleotide exchange factor B (also called Trix), and similar proteins. dMP20 is present only in the synchronous muscles of D. melanogaster. It may be involved in the system linking the nerve impulse with the contraction or the relaxation process. Trix is involved in the regulation of the late steps of the endocytic pathway. dMP20 contains a single copy of the CH domain, while Trix (triple CH-domain array exchange factor) contains three, two type 3 CH domains which are included in this model, and one type 1 CH domain that is not included in this subfamily, but is part of the superfamily. CH domains are actin filament (F-actin) binding motifs. Pssm-ID: 409056 [Multi-domain] Cd Length: 107 Bit Score: 78.51 E-value: 3.13e-17
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| RasGAP | cd04519 | Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is ... |
871-1100 | 3.34e-14 | ||||||||||||||||||||
Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin, among others. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP exhibit no similarity at their amino acid sequence level. RasGTPases function as molecular switches in a large number of signaling pathways. They are in the on state when bound to GTP, and in the off state when bound to GDP. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator. Pssm-ID: 213328 Cd Length: 256 Bit Score: 74.45 E-value: 3.34e-14
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| CH | smart00033 | Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ... |
113-213 | 1.34e-13 | ||||||||||||||||||||
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p. Pssm-ID: 214479 [Multi-domain] Cd Length: 101 Bit Score: 68.11 E-value: 1.34e-13
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| CH_SCP1-like | cd21210 | calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar ... |
113-213 | 9.58e-12 | ||||||||||||||||||||
calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar proteins; The family includes transgelins from Saccharomyces cerevisiae and Schizosaccharomyces pombe, which are also called SCP1 and STG1, respectively. Transgelin, also called calponin homolog 1, has actin-binding and actin-bundling activity. It stabilizes actin filaments against disassembly. Transgelin contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs. Pssm-ID: 409059 [Multi-domain] Cd Length: 101 Bit Score: 62.77 E-value: 9.58e-12
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| SCP1 | COG5199 | Calponin [Cytoskeleton]; |
113-228 | 1.78e-10 | ||||||||||||||||||||
Calponin [Cytoskeleton]; Pssm-ID: 227526 [Multi-domain] Cd Length: 178 Bit Score: 61.47 E-value: 1.78e-10
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| CH | pfam00307 | Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ... |
108-219 | 1.31e-09 | ||||||||||||||||||||
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy. Pssm-ID: 425596 [Multi-domain] Cd Length: 109 Bit Score: 56.91 E-value: 1.31e-09
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| RasGAP | pfam00616 | GTPase-activator protein for Ras-like GTPase; All alpha-helical domain that accelerates the ... |
884-1058 | 2.26e-08 | ||||||||||||||||||||
GTPase-activator protein for Ras-like GTPase; All alpha-helical domain that accelerates the GTPase activity of Ras, thereby "switching" it into an "off" position. Pssm-ID: 459871 Cd Length: 207 Bit Score: 56.14 E-value: 2.26e-08
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| CH_VAV | cd21201 | calponin homology (CH) domain found in VAV proteins; VAV proteins function both as cytoplasmic ... |
125-213 | 7.16e-08 | ||||||||||||||||||||
calponin homology (CH) domain found in VAV proteins; VAV proteins function both as cytoplasmic guanine nucleotide exchange factors (GEFs) for Rho GTPases and as scaffold proteins, and they play important roles in cell signaling by coupling cell surface receptors to various effector functions. They play key roles in processes that require cytoskeletal reorganization including immune synapse formation, phagocytosis, cell spreading, and platelet aggregation, among others. Vertebrates have three VAV proteins (VAV1, VAV2, and VAV3). VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. This model corresponds to the CH domain, an actin-binding domain which is present as a single copy in VAV proteins. Pssm-ID: 409050 Cd Length: 117 Bit Score: 52.26 E-value: 7.16e-08
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| CH_LMO7-like | cd21208 | calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This ... |
111-198 | 7.59e-08 | ||||||||||||||||||||
calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This family includes LIM domain only protein 7 (LMO-7) and LIM and calponin homology domains-containing protein 1 (LIMCH1), and similar proteins. LMO-7, also called F-box only protein 20, or LOMP, is a transcription regulator for expression of many Emery-Dreifuss muscular dystrophy (EDMD)-relevant genes. It binds to alpha-actinin and AF6/afadin at adherens junctions for epithelial cell-cell adhesion. LIMCH1 acts as an actin stress fiber-associated protein that activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. It positively regulates actin stress fiber assembly and stabilizes focal adhesions, and therefore negatively regulates cell spreading and cell migration. Members of this family contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs. Pssm-ID: 409057 [Multi-domain] Cd Length: 119 Bit Score: 52.34 E-value: 7.59e-08
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| CH_CNN3 | cd21284 | calponin homology (CH) domain found in calponin-3; Calponin-3 (CNN3), also called acidic ... |
113-220 | 2.34e-04 | ||||||||||||||||||||
calponin homology (CH) domain found in calponin-3; Calponin-3 (CNN3), also called acidic isoform calponin, is an F-actin-binding protein that is expressed in the brain and has been shown to control dendritic spine morphology, density, and plasticity by regulating actin cytoskeletal reorganization and dynamics. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs. Pssm-ID: 409133 [Multi-domain] Cd Length: 111 Bit Score: 42.20 E-value: 2.34e-04
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| CH_AtKIN14-like | cd21203 | calponin homology (CH) domain found in Arabidopsis thaliana Kinesin-like KIN-14 protein family; ... |
117-197 | 8.11e-04 | ||||||||||||||||||||
calponin homology (CH) domain found in Arabidopsis thaliana Kinesin-like KIN-14 protein family; Kinesins are microtubule-dependent molecular motors that play important roles in intracellular transport and in cell division. This family includes a group of kinesin-like proteins belonging to KIN-14 protein family. They all contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs. Pssm-ID: 409052 [Multi-domain] Cd Length: 112 Bit Score: 40.48 E-value: 8.11e-04
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| CH_CNN1 | cd21282 | calponin homology (CH) domain found in calponin-1 and similar proteins; Calponin-1 (CNN1), ... |
113-220 | 3.25e-03 | ||||||||||||||||||||
calponin homology (CH) domain found in calponin-1 and similar proteins; Calponin-1 (CNN1), also called basic calponin, or smooth muscle calponin H1, is a thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C, and tropomyosin. Calponin-1 contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs. Pssm-ID: 409131 [Multi-domain] Cd Length: 108 Bit Score: 38.70 E-value: 3.25e-03
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| 235kDa-fam | TIGR01612 | reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ... |
1013-1362 | 4.36e-03 | ||||||||||||||||||||
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii. Pssm-ID: 130673 [Multi-domain] Cd Length: 2757 Bit Score: 41.96 E-value: 4.36e-03
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