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Conserved domains on  [gi|6325111|ref|NP_015179|]
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Nop53p [Saccharomyces cerevisiae S288C]

Protein Classification

ribosome biogenesis protein NOP53( domain architecture ID 12083027)

ribosome biogenesis protein NOP53 is a nucleolar protein which is involved in the regulation of several cell functions, including integration of 5S RNP into ribosomal large subunit, ribosome biogenesis, sensor-regulating the activation of p53/TP53 in response to stress conditions, and tumor suppression.

Gene Ontology:  GO:0000027|GO:0006364

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nop53 pfam07767
Nop53 (60S ribosomal biogenesis); This nucleolar family of proteins are involved in 60S ...
 17-423 1.77e-73

Nop53 (60S ribosomal biogenesis); This nucleolar family of proteins are involved in 60S ribosomal biogenesis. They are specifically involved in the processing beyond the 27S stage of 25S rRNA maturation. This family contains sequences that bear similarity to the glioma tumour suppressor candidate region gene 2 protein (p60). This protein has been found to interact with herpes simplex type 1 regulatory proteins.


:

Pssm-ID: 462259 [Multi-domain]  Cd Length: 353  Bit Score: 234.88  E-value: 1.77e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325111     17 SRKGKKAWRKNIDLSDVEQYMEKKIDHEITHGtsDITSLQNDALFHVDVEGDEILKNKLikRKQIKKVLKSKEILdavKT 96
Cdd:pfam07767   1 SRKGKKAWRKNIDITDVEDGLEEVREEIITGG--VLSEKPDDELFVVDTKGDEELKKKL--RKKIKKPLKSDEIL---AQ 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325111     97 NSKIAALNHHKNSSGNP-NKIQGVSKHELKKLMALAGRVHGESKIKNRVAKDGLVKTTAGDLWGEesnskkqkvklpsgi 175
Cdd:pfam07767  74 RSAVPAVSHKRKRPGAKkLKKKKVSKKELARLRKLAKGKRKGEKKLEKSAKDGLVFSGTYDLWGE--------------- 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325111    176 klDVEKKDQIPEELLKKSTTSWSTASVRPSTLDIEPIAVKEFT--EIPHAGKSYNPNNKAWSELINKEYKEEKAREDERI 253
Cdd:pfam07767 139 --EEEPEVEKKEEEHTLSFLEKKKKVKAPKTLKHKPISLTALPavEVPHAGTSYNPSFEDHQELLQKAVEAEKKRLKEEE 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325111    254 ALEKYKERIRHLMETLDDNeeeesssneeeeeeeeenenenestqcsgsDKEIKlsinkpvknkkkTKYQRNKAKRHEEK 333
Cdd:pfam07767 217 KLERVLEKIAESAATAEAR------------------------------EEKRK------------TKAQRNKEKRRKEE 254

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325111    334 VKLQQELKELRQRVKDLEEV------INSEETEILSAIESDSNKVKKSKKNKKHKLG---TKYSVIDERLEIKFSDELSD 404
Cdd:pfam07767 255 EREAKEEKALKKKLAQLERLkeiakeIAEKEKEREEKAEARKREKRKKKKEEKKLRPrklGKHKVPEPDLEVQLPDELSG 334

                         410
                  ....*....|....*....
gi 6325111    405 SLRKLKPEGNLLYDTVRKL 423
Cdd:pfam07767 335 SLRLLKPEGNLLKDRFKSL 353
 
Name Accession Description Interval E-value
Nop53 pfam07767
Nop53 (60S ribosomal biogenesis); This nucleolar family of proteins are involved in 60S ...
 17-423 1.77e-73

Nop53 (60S ribosomal biogenesis); This nucleolar family of proteins are involved in 60S ribosomal biogenesis. They are specifically involved in the processing beyond the 27S stage of 25S rRNA maturation. This family contains sequences that bear similarity to the glioma tumour suppressor candidate region gene 2 protein (p60). This protein has been found to interact with herpes simplex type 1 regulatory proteins.


Pssm-ID: 462259 [Multi-domain]  Cd Length: 353  Bit Score: 234.88  E-value: 1.77e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325111     17 SRKGKKAWRKNIDLSDVEQYMEKKIDHEITHGtsDITSLQNDALFHVDVEGDEILKNKLikRKQIKKVLKSKEILdavKT 96
Cdd:pfam07767   1 SRKGKKAWRKNIDITDVEDGLEEVREEIITGG--VLSEKPDDELFVVDTKGDEELKKKL--RKKIKKPLKSDEIL---AQ 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325111     97 NSKIAALNHHKNSSGNP-NKIQGVSKHELKKLMALAGRVHGESKIKNRVAKDGLVKTTAGDLWGEesnskkqkvklpsgi 175
Cdd:pfam07767  74 RSAVPAVSHKRKRPGAKkLKKKKVSKKELARLRKLAKGKRKGEKKLEKSAKDGLVFSGTYDLWGE--------------- 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325111    176 klDVEKKDQIPEELLKKSTTSWSTASVRPSTLDIEPIAVKEFT--EIPHAGKSYNPNNKAWSELINKEYKEEKAREDERI 253
Cdd:pfam07767 139 --EEEPEVEKKEEEHTLSFLEKKKKVKAPKTLKHKPISLTALPavEVPHAGTSYNPSFEDHQELLQKAVEAEKKRLKEEE 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325111    254 ALEKYKERIRHLMETLDDNeeeesssneeeeeeeeenenenestqcsgsDKEIKlsinkpvknkkkTKYQRNKAKRHEEK 333
Cdd:pfam07767 217 KLERVLEKIAESAATAEAR------------------------------EEKRK------------TKAQRNKEKRRKEE 254

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325111    334 VKLQQELKELRQRVKDLEEV------INSEETEILSAIESDSNKVKKSKKNKKHKLG---TKYSVIDERLEIKFSDELSD 404
Cdd:pfam07767 255 EREAKEEKALKKKLAQLERLkeiakeIAEKEKEREEKAEARKREKRKKKKEEKKLRPrklGKHKVPEPDLEVQLPDELSG 334

                         410
                  ....*....|....*....
gi 6325111    405 SLRKLKPEGNLLYDTVRKL 423
Cdd:pfam07767 335 SLRLLKPEGNLLKDRFKSL 353
 
Name Accession Description Interval E-value
Nop53 pfam07767
Nop53 (60S ribosomal biogenesis); This nucleolar family of proteins are involved in 60S ...
 17-423 1.77e-73

Nop53 (60S ribosomal biogenesis); This nucleolar family of proteins are involved in 60S ribosomal biogenesis. They are specifically involved in the processing beyond the 27S stage of 25S rRNA maturation. This family contains sequences that bear similarity to the glioma tumour suppressor candidate region gene 2 protein (p60). This protein has been found to interact with herpes simplex type 1 regulatory proteins.


Pssm-ID: 462259 [Multi-domain]  Cd Length: 353  Bit Score: 234.88  E-value: 1.77e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325111     17 SRKGKKAWRKNIDLSDVEQYMEKKIDHEITHGtsDITSLQNDALFHVDVEGDEILKNKLikRKQIKKVLKSKEILdavKT 96
Cdd:pfam07767   1 SRKGKKAWRKNIDITDVEDGLEEVREEIITGG--VLSEKPDDELFVVDTKGDEELKKKL--RKKIKKPLKSDEIL---AQ 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325111     97 NSKIAALNHHKNSSGNP-NKIQGVSKHELKKLMALAGRVHGESKIKNRVAKDGLVKTTAGDLWGEesnskkqkvklpsgi 175
Cdd:pfam07767  74 RSAVPAVSHKRKRPGAKkLKKKKVSKKELARLRKLAKGKRKGEKKLEKSAKDGLVFSGTYDLWGE--------------- 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325111    176 klDVEKKDQIPEELLKKSTTSWSTASVRPSTLDIEPIAVKEFT--EIPHAGKSYNPNNKAWSELINKEYKEEKAREDERI 253
Cdd:pfam07767 139 --EEEPEVEKKEEEHTLSFLEKKKKVKAPKTLKHKPISLTALPavEVPHAGTSYNPSFEDHQELLQKAVEAEKKRLKEEE 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325111    254 ALEKYKERIRHLMETLDDNeeeesssneeeeeeeeenenenestqcsgsDKEIKlsinkpvknkkkTKYQRNKAKRHEEK 333
Cdd:pfam07767 217 KLERVLEKIAESAATAEAR------------------------------EEKRK------------TKAQRNKEKRRKEE 254

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325111    334 VKLQQELKELRQRVKDLEEV------INSEETEILSAIESDSNKVKKSKKNKKHKLG---TKYSVIDERLEIKFSDELSD 404
Cdd:pfam07767 255 EREAKEEKALKKKLAQLERLkeiakeIAEKEKEREEKAEARKREKRKKKKEEKKLRPrklGKHKVPEPDLEVQLPDELSG 334

                         410
                  ....*....|....*....
gi 6325111    405 SLRKLKPEGNLLYDTVRKL 423
Cdd:pfam07767 335 SLRLLKPEGNLLKDRFKSL 353
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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