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Conserved domains on  [gi|6325118|ref|NP_015186|]
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Ume1p [Saccharomyces cerevisiae S288C]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1903264)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl43672
WD40 repeat [General function prediction only];
191-309 2.22e-05

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.44  E-value: 2.22e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325118  191 AISNDSKTLTVTkekhldNENATIKLIDNSGkiGEVLRTIPVPGiKNIQEIKFL-NNQIFATCSDDGIIRFWGNEIGkKP 269
Cdd:COG2319 253 AFSPDGRLLASG------SADGTVRLWDLAT--GELLRTLTGHS-GGVNSVAFSpDGKLLASGSDDGTVRLWDLATG-KL 322

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 6325118  270 LWILNDSlDGKTTCFAASPFVDTLFmTGTSGGALKVWDIR 309
Cdd:COG2319 323 LRTLTGH-TGAVRSVAFSPDGKTLA-SGSDDGTVRLWDLA 360
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
191-309 2.22e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.44  E-value: 2.22e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325118  191 AISNDSKTLTVTkekhldNENATIKLIDNSGkiGEVLRTIPVPGiKNIQEIKFL-NNQIFATCSDDGIIRFWGNEIGkKP 269
Cdd:COG2319 253 AFSPDGRLLASG------SADGTVRLWDLAT--GELLRTLTGHS-GGVNSVAFSpDGKLLASGSDDGTVRLWDLATG-KL 322

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 6325118  270 LWILNDSlDGKTTCFAASPFVDTLFmTGTSGGALKVWDIR 309
Cdd:COG2319 323 LRTLTGH-TGAVRSVAFSPDGKTLA-SGSDDGTVRLWDLA 360
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
191-309 2.22e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.44  E-value: 2.22e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325118  191 AISNDSKTLTVTkekhldNENATIKLIDNSGkiGEVLRTIPVPGiKNIQEIKFL-NNQIFATCSDDGIIRFWGNEIGkKP 269
Cdd:COG2319 253 AFSPDGRLLASG------SADGTVRLWDLAT--GELLRTLTGHS-GGVNSVAFSpDGKLLASGSDDGTVRLWDLATG-KL 322

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 6325118  270 LWILNDSlDGKTTCFAASPFVDTLFmTGTSGGALKVWDIR 309
Cdd:COG2319 323 LRTLTGH-TGAVRSVAFSPDGKTLA-SGSDDGTVRLWDLA 360
WD40 COG2319
WD40 repeat [General function prediction only];
191-309 4.65e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.21  E-value: 4.65e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325118  191 AISNDSKTLTVTkekhldNENATIKLIDNSGkiGEVLRTIPVPGiKNIQEIKFL-NNQIFATCSDDGIIRFWgNEIGKKP 269
Cdd:COG2319 169 AFSPDGKLLASG------SDDGTVRLWDLAT--GKLLRTLTGHT-GAVRSVAFSpDGKLLASGSADGTVRLW-DLATGKL 238

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 6325118  270 LWILNDSlDGKTTCFAASPfvD-TLFMTGTSGGALKVWDIR 309
Cdd:COG2319 239 LRTLTGH-SGSVRSVAFSP--DgRLLASGSADGTVRLWDLA 276
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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