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Conserved domains on  [gi|6325366|ref|NP_015434|]
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Gld1p [Saccharomyces cerevisiae S288C]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF1746 super family cl07217
Fungal domain of unknown function (DUF1746); This is a fungal domain of unknown function. This ...
 34-230 8.30e-03

Fungal domain of unknown function (DUF1746); This is a fungal domain of unknown function. This domain can be found in DSC E3 ubiquitin ligase complex subunit 4 (Dsc4) from S. pombe, a component of the DSC E3 ubiquitin ligase complex required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex plays also an important role in the multivesicular body (MVB) pathway and functions in a post-endoplasmic reticulum pathway for protein degradation. This domain is also found in GLD1 from S. cerevisiae, also a component of the DSC E3 ubiquitin ligase complex involved in the targeting of the DSC complex to the Golgi apparatus and endosome membranes via the AP3 pathway to ubiquitinate Golgi/endosome membrane proteins.


The actual alignment was detected with superfamily member pfam08508:

Pssm-ID: 430039  Cd Length: 116  Bit Score: 35.61  E-value: 8.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325366     34 NLSFLGYVLISLEYIKYDRTVWTLItRAIVQSLISSPFPSDAKLrrlatlgadnnttgvaTLPggrsirfpgmfgtemly 113
Cdd:pfam08508   1 SLDLLCYVLLSILYYMDCSFFRLLL-RAFVQLSFLTPKPPHFPE----------------PLP----------------- 46

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325366    114 nssseaeqqdhddtaivsmkkqIRKFLFHGCLSLNMLFIILTILFPIdffeplsgsepvddgpkntPSPFSNSDGLLlge 193
Cdd:pfam08508  47 ----------------------ANRPLLVAILGSNLLCLLLHLLFGL-------------------PSAGEATRGYL--- 82

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 6325366    194 rRGGLFLQMIGERLPKSNFsgnlGLVMFEFSILIVQF 230
Cdd:pfam08508  83 -HGGLIIDFIGQKGPSSRL----HLLLLDLLILALQL 114
 
Name Accession Description Interval E-value
DUF1746 pfam08508
Fungal domain of unknown function (DUF1746); This is a fungal domain of unknown function. This ...
 34-230 8.30e-03

Fungal domain of unknown function (DUF1746); This is a fungal domain of unknown function. This domain can be found in DSC E3 ubiquitin ligase complex subunit 4 (Dsc4) from S. pombe, a component of the DSC E3 ubiquitin ligase complex required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex plays also an important role in the multivesicular body (MVB) pathway and functions in a post-endoplasmic reticulum pathway for protein degradation. This domain is also found in GLD1 from S. cerevisiae, also a component of the DSC E3 ubiquitin ligase complex involved in the targeting of the DSC complex to the Golgi apparatus and endosome membranes via the AP3 pathway to ubiquitinate Golgi/endosome membrane proteins.


Pssm-ID: 430039  Cd Length: 116  Bit Score: 35.61  E-value: 8.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325366     34 NLSFLGYVLISLEYIKYDRTVWTLItRAIVQSLISSPFPSDAKLrrlatlgadnnttgvaTLPggrsirfpgmfgtemly 113
Cdd:pfam08508   1 SLDLLCYVLLSILYYMDCSFFRLLL-RAFVQLSFLTPKPPHFPE----------------PLP----------------- 46

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325366    114 nssseaeqqdhddtaivsmkkqIRKFLFHGCLSLNMLFIILTILFPIdffeplsgsepvddgpkntPSPFSNSDGLLlge 193
Cdd:pfam08508  47 ----------------------ANRPLLVAILGSNLLCLLLHLLFGL-------------------PSAGEATRGYL--- 82

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 6325366    194 rRGGLFLQMIGERLPKSNFsgnlGLVMFEFSILIVQF 230
Cdd:pfam08508  83 -HGGLIIDFIGQKGPSSRL----HLLLLDLLILALQL 114
 
Name Accession Description Interval E-value
DUF1746 pfam08508
Fungal domain of unknown function (DUF1746); This is a fungal domain of unknown function. This ...
 34-230 8.30e-03

Fungal domain of unknown function (DUF1746); This is a fungal domain of unknown function. This domain can be found in DSC E3 ubiquitin ligase complex subunit 4 (Dsc4) from S. pombe, a component of the DSC E3 ubiquitin ligase complex required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex plays also an important role in the multivesicular body (MVB) pathway and functions in a post-endoplasmic reticulum pathway for protein degradation. This domain is also found in GLD1 from S. cerevisiae, also a component of the DSC E3 ubiquitin ligase complex involved in the targeting of the DSC complex to the Golgi apparatus and endosome membranes via the AP3 pathway to ubiquitinate Golgi/endosome membrane proteins.


Pssm-ID: 430039  Cd Length: 116  Bit Score: 35.61  E-value: 8.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325366     34 NLSFLGYVLISLEYIKYDRTVWTLItRAIVQSLISSPFPSDAKLrrlatlgadnnttgvaTLPggrsirfpgmfgtemly 113
Cdd:pfam08508   1 SLDLLCYVLLSILYYMDCSFFRLLL-RAFVQLSFLTPKPPHFPE----------------PLP----------------- 46

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325366    114 nssseaeqqdhddtaivsmkkqIRKFLFHGCLSLNMLFIILTILFPIdffeplsgsepvddgpkntPSPFSNSDGLLlge 193
Cdd:pfam08508  47 ----------------------ANRPLLVAILGSNLLCLLLHLLFGL-------------------PSAGEATRGYL--- 82

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 6325366    194 rRGGLFLQMIGERLPKSNFsgnlGLVMFEFSILIVQF 230
Cdd:pfam08508  83 -HGGLIIDFIGQKGPSSRL----HLLLLDLLILALQL 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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