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Conserved domains on  [gi|6325370|ref|NP_015438|]
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CDP-diacylglycerol--inositol 3-phosphatidyltransferase [Saccharomyces cerevisiae S288C]

Protein Classification

CDP-alcohol phosphatidyltransferase family protein( domain architecture ID 10001704)

CDP-alcohol phosphatidyltransferase family protein catalyzes the transfer of a substituted phosphate group from a cytidine-5'-diphosphate-linked donor to an alcohol acceptor, an essential reaction in the biosynthesis of phospholipids

CATH:  1.20.120.1760
EC:  2.7.8.-
Gene Ontology:  GO:0016780|GO:0008654|GO:0016020|GO:0000287
PubMed:  24923293|24573438|21259003|24942835
SCOP:  3002413

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PgsA COG0558
Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; ...
 9-120 3.43e-13

Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; Phosphatidylglycerophosphate synthase is part of the Pathway/BioSystem: Phospholipid biosynthesis


:

Pssm-ID: 440324 [Multi-domain]  Cd Length: 177  Bit Score: 65.27  E-value: 3.43e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325370    9 KVTAEHVLWYIPNKIGYVRVITA--ALSFFVMKNHPTAFTWLYSTSCLLDALDGTMARKYNQVSSLGAVLDMVTDRSSTA 86
Cdd:COG0558   1 RPAFQRRLLNIPNQLTLLRILLVpvFALLLLLGGALLLALVLFLLAGLTDALDGYLARRLGQVSRFGAFLDPVADKLLDA 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 6325370   87 GLMCFLCVQY--PQWCVFfqLMLGLDITSHYMHMYA 120
Cdd:COG0558  81 AALLGLVLLGllPAWLAL--LILLRELLVSYLRARA 114
 
Name Accession Description Interval E-value
PgsA COG0558
Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; ...
 9-120 3.43e-13

Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; Phosphatidylglycerophosphate synthase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440324 [Multi-domain]  Cd Length: 177  Bit Score: 65.27  E-value: 3.43e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325370    9 KVTAEHVLWYIPNKIGYVRVITA--ALSFFVMKNHPTAFTWLYSTSCLLDALDGTMARKYNQVSSLGAVLDMVTDRSSTA 86
Cdd:COG0558   1 RPAFQRRLLNIPNQLTLLRILLVpvFALLLLLGGALLLALVLFLLAGLTDALDGYLARRLGQVSRFGAFLDPVADKLLDA 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 6325370   87 GLMCFLCVQY--PQWCVFfqLMLGLDITSHYMHMYA 120
Cdd:COG0558  81 AALLGLVLLGllPAWLAL--LILLRELLVSYLRARA 114
CDP-OH_P_transf pfam01066
CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the ...
 17-111 4.27e-11

CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.


Pssm-ID: 460049 [Multi-domain]  Cd Length: 157  Bit Score: 59.11  E-value: 4.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325370     17 WYIPNKIGYVRV--ITAALSFFVMKNHPTAFTWLYSTSCLLDALDGTMARKYNQVSSLGAVLDMVTDRSSTAGLMCFLCV 94
Cdd:pfam01066   1 LNLPNLLTLLRIllVPVFVVLLLGPGNRILAAVVFALAALTDFLDGKIARKLNQVTDFGKFLDPLADKLLVAAALIALSI 80

                          90
                  ....*....|....*..
gi 6325370     95 QYPQWCVFFQLMLGLDI 111
Cdd:pfam01066  81 LGLLPWWFVVVILVREL 97
pgsA TIGR00560
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: ...
 19-82 2.29e-06

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: phosphatidylglycerophosphate synthase; glycerophosphate phosphatidyltransferase; PGP synthase. A number of related enzymes are quite similar in both sequence and catalytic activity, including Saccharamyces cerevisiae YDL142c, now known to be a cardiolipin synthase. There may be problems with incorrect transitive annotation of near homologs as authentic CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273139 [Multi-domain]  Cd Length: 182  Bit Score: 46.19  E-value: 2.29e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6325370     19 IPNKIGYVRVITAALSFFVMKNHPTAFTW-------LYSTSCLLDALDGTMARKYNQVSSLGAVLDMVTDR 82
Cdd:TIGR00560   3 IPNWLTLFRIIALPIFILFFLENVLPIQVspfigalLFIFAAVTDWLDGYLARKWNQVSNFGKFLDPLADK 73
PLN02558 PLN02558
CDP-diacylglycerol-glycerol-3-phosphate/ 3-phosphatidyltransferase
 43-93 1.61e-03

CDP-diacylglycerol-glycerol-3-phosphate/ 3-phosphatidyltransferase


Pssm-ID: 166199  Cd Length: 203  Bit Score: 38.09  E-value: 1.61e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 6325370    43 TAFTWLYSTSCLLDALDGTMARKYNQVSSLGAVLDMVTDRSSTAGLMCFLC 93
Cdd:PLN02558  39 TATTSIFIAAAITDWLDGYLARKMKLGTAFGAFLDPVADKLMVAAALILLC 89
 
Name Accession Description Interval E-value
PgsA COG0558
Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; ...
 9-120 3.43e-13

Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; Phosphatidylglycerophosphate synthase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440324 [Multi-domain]  Cd Length: 177  Bit Score: 65.27  E-value: 3.43e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325370    9 KVTAEHVLWYIPNKIGYVRVITA--ALSFFVMKNHPTAFTWLYSTSCLLDALDGTMARKYNQVSSLGAVLDMVTDRSSTA 86
Cdd:COG0558   1 RPAFQRRLLNIPNQLTLLRILLVpvFALLLLLGGALLLALVLFLLAGLTDALDGYLARRLGQVSRFGAFLDPVADKLLDA 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 6325370   87 GLMCFLCVQY--PQWCVFfqLMLGLDITSHYMHMYA 120
Cdd:COG0558  81 AALLGLVLLGllPAWLAL--LILLRELLVSYLRARA 114
CDP-OH_P_transf pfam01066
CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the ...
 17-111 4.27e-11

CDP-alcohol phosphatidyltransferase; All of these members have the ability to catalyze the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.


Pssm-ID: 460049 [Multi-domain]  Cd Length: 157  Bit Score: 59.11  E-value: 4.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325370     17 WYIPNKIGYVRV--ITAALSFFVMKNHPTAFTWLYSTSCLLDALDGTMARKYNQVSSLGAVLDMVTDRSSTAGLMCFLCV 94
Cdd:pfam01066   1 LNLPNLLTLLRIllVPVFVVLLLGPGNRILAAVVFALAALTDFLDGKIARKLNQVTDFGKFLDPLADKLLVAAALIALSI 80

                          90
                  ....*....|....*..
gi 6325370     95 QYPQWCVFFQLMLGLDI 111
Cdd:pfam01066  81 LGLLPWWFVVVILVREL 97
pgsA TIGR00560
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: ...
 19-82 2.29e-06

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Alternate names: phosphatidylglycerophosphate synthase; glycerophosphate phosphatidyltransferase; PGP synthase. A number of related enzymes are quite similar in both sequence and catalytic activity, including Saccharamyces cerevisiae YDL142c, now known to be a cardiolipin synthase. There may be problems with incorrect transitive annotation of near homologs as authentic CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273139 [Multi-domain]  Cd Length: 182  Bit Score: 46.19  E-value: 2.29e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6325370     19 IPNKIGYVRVITAALSFFVMKNHPTAFTW-------LYSTSCLLDALDGTMARKYNQVSSLGAVLDMVTDR 82
Cdd:TIGR00560   3 IPNWLTLFRIIALPIFILFFLENVLPIQVspfigalLFIFAAVTDWLDGYLARKWNQVSNFGKFLDPLADK 73
PLN02558 PLN02558
CDP-diacylglycerol-glycerol-3-phosphate/ 3-phosphatidyltransferase
 43-93 1.61e-03

CDP-diacylglycerol-glycerol-3-phosphate/ 3-phosphatidyltransferase


Pssm-ID: 166199  Cd Length: 203  Bit Score: 38.09  E-value: 1.61e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 6325370    43 TAFTWLYSTSCLLDALDGTMARKYNQVSSLGAVLDMVTDRSSTAGLMCFLC 93
Cdd:PLN02558  39 TATTSIFIAAAITDWLDGYLARKMKLGTAFGAFLDPVADKLMVAAALILLC 89
PRK10832 PRK10832
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;
19-101 2.57e-03

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase;


Pssm-ID: 182763 [Multi-domain]  Cd Length: 182  Bit Score: 37.52  E-value: 2.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325370    19 IPNKIGYVRVITaaLSFFVMKNHpTAFTW-------LYSTSCLLDALDGTMARKYNQVSSLGAVLDMVTDRSSTAGLMCF 91
Cdd:PRK10832   5 IPTLLTLFRVIL--IPFFVLVFY-LPFTWapfvcalIFCVAAVTDWFDGFLARRWNQSTRFGAFLDPVADKVMVAIAMVL 81

                         90
                 ....*....|
gi 6325370    92 LCVQYPQWCV 101
Cdd:PRK10832  82 VTEHYHSWWV 91
PssA COG1183
Phosphatidylserine synthase [Lipid transport and metabolism];
35-81 8.01e-03

Phosphatidylserine synthase [Lipid transport and metabolism];


Pssm-ID: 440796 [Multi-domain]  Cd Length: 237  Bit Score: 36.33  E-value: 8.01e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 6325370   35 FFVMKNHPTAFTWLYSTSCLLDALDGTMARKYNQVSSLGAVLDMVTD 81
Cdd:COG1183  29 VAAIEGDFELAALLILLAAVFDGLDGRVARLLNVQSEFGAELDSLAD 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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