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Conserved domains on  [gi|6325376|ref|NP_015444|]
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B-type cyclin CLB2 [Saccharomyces cerevisiae S288C]

Protein Classification

cyclin family protein( domain architecture ID 11472088)

cyclin family protein may associate with and activate its cognate cyclin-dependent kinase (CDK); similar to Saccharomyces cerevisiae S288C G1/S-specific cyclins and G2/mitotic-specific cyclins

CATH:  1.10.472.10
Gene Ontology:  GO:0000079|GO:0019901
PubMed:  30185601
SCOP:  4001102

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
8-487 5.92e-154

Cyclin [Cell division and chromosome partitioning];


:

Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 445.37  E-value: 5.92e-154
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376    8 TENSQNTSSSRFLRNVQRLALNNVTNTTFQKSNANNPALTNFKSTLNSVKKEGSRIPQFTRESVSRSTAAQEEKRTlken 87
Cdd:COG5024   1 HSESLQEYHQEISRNVAVQSSKNKPNVKLILQQPEMNILETRSAIVDFLNQLSTVTRLSNGINFHSSKSTKLVVGT---- 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376   88 giqlpknnllddkenqdpssqqfgALTSIKEGRAelpaNISLQESSSAKEIIQHDPlkgvgssTEVVHNSVENEKlhpar 167
Cdd:COG5024  77 ------------------------CLWLAKKTWG----IISSGESNERARIPRLSE-------CNLDSILFIQMT----- 116

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  168 sQLQVRNTESETDSGKKRPISTIVEQELPKKFKVCD---ENGKEEYEWEDLDAEDVNDPFMVSEYVNDIFEYLHQLEVIT 244
Cdd:COG5024 117 -LNEDSYEPMIDYILKKDENSLSPYELDENQLALDEkqaESKRESQSWQDLDATDQEDPLMVPEYASDIFEYLLKLELID 195

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  245 LPKKEDLYQHRNIH-QNRDILVNWLVKIHNKFGLLPETLYLAINIMDRFLGKELVQLDKLQLVGTSCLFIASKYEEVYSP 323
Cdd:COG5024 196 LPNPNYLIKQSLYEwSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEKYQLVGISALFIASKYEEVNCP 275

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  324 SIKHFASETDGACTEDEIKEGEKFILKTLKFNLNYPNPMNFLRRISKADDYDIQSRTLAKFLLEISLVDFRFIGILPSLC 403
Cdd:COG5024 276 SIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKASDYDIFSRTPAKFSSEISPVDYKFIQISPSWC 355

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  404 AAAAMFMSRKMLGKGKWDGNLIHYSGGYTKEELAPVCHMIMDYLVSPIVH-DEFHRKYQSRRFMKASIISVQWALKVRKN 482
Cdd:COG5024 356 AAAAMYLSRKILSQNQWDRTLIHYSGNYTNPDLKPLNESNKENLQNPSVHhDAIFPKYPSPTFGKASSPTGEWIRSNSSN 435


                ....*
gi 6325376  483 GYDIM 487
Cdd:COG5024 436 DSSLL 440
 
Name Accession Description Interval E-value
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
8-487 5.92e-154

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 445.37  E-value: 5.92e-154
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376    8 TENSQNTSSSRFLRNVQRLALNNVTNTTFQKSNANNPALTNFKSTLNSVKKEGSRIPQFTRESVSRSTAAQEEKRTlken 87
Cdd:COG5024   1 HSESLQEYHQEISRNVAVQSSKNKPNVKLILQQPEMNILETRSAIVDFLNQLSTVTRLSNGINFHSSKSTKLVVGT---- 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376   88 giqlpknnllddkenqdpssqqfgALTSIKEGRAelpaNISLQESSSAKEIIQHDPlkgvgssTEVVHNSVENEKlhpar 167
Cdd:COG5024  77 ------------------------CLWLAKKTWG----IISSGESNERARIPRLSE-------CNLDSILFIQMT----- 116

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  168 sQLQVRNTESETDSGKKRPISTIVEQELPKKFKVCD---ENGKEEYEWEDLDAEDVNDPFMVSEYVNDIFEYLHQLEVIT 244
Cdd:COG5024 117 -LNEDSYEPMIDYILKKDENSLSPYELDENQLALDEkqaESKRESQSWQDLDATDQEDPLMVPEYASDIFEYLLKLELID 195

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  245 LPKKEDLYQHRNIH-QNRDILVNWLVKIHNKFGLLPETLYLAINIMDRFLGKELVQLDKLQLVGTSCLFIASKYEEVYSP 323
Cdd:COG5024 196 LPNPNYLIKQSLYEwSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEKYQLVGISALFIASKYEEVNCP 275

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  324 SIKHFASETDGACTEDEIKEGEKFILKTLKFNLNYPNPMNFLRRISKADDYDIQSRTLAKFLLEISLVDFRFIGILPSLC 403
Cdd:COG5024 276 SIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKASDYDIFSRTPAKFSSEISPVDYKFIQISPSWC 355

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  404 AAAAMFMSRKMLGKGKWDGNLIHYSGGYTKEELAPVCHMIMDYLVSPIVH-DEFHRKYQSRRFMKASIISVQWALKVRKN 482
Cdd:COG5024 356 AAAAMYLSRKILSQNQWDRTLIHYSGNYTNPDLKPLNESNKENLQNPSVHhDAIFPKYPSPTFGKASSPTGEWIRSNSSN 435


                ....*
gi 6325376  483 GYDIM 487
Cdd:COG5024 436 DSSLL 440
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 222-354 7.14e-81

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 247.21  E-value: 7.14e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  222 DPFMVSEYVNDIFEYLHQLEVITLPKKEDLY-QHRNIHQNRDILVNWLVKIHNKFGLLPETLYLAINIMDRFLGKELVQL 300
Cdd:cd20568   1 DPLMVAEYVPEIFEYLRELELKTLPNPNYMDdQKELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLSKRVVSL 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 6325376  301 DKLQLVGTSCLFIASKYEEVYSPSIKHFASETDGACTEDEIKEGEKFILKTLKF 354
Cdd:cd20568  81 NKLQLVGISALFIASKYEEVNSPSIKNFAYMTDGAYTVEDILRAERYMLNTLEF 134
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 232-357 3.81e-54

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 177.71  E-value: 3.81e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376    232 DIFEYLHQLEVITLPKKEDLYQHRNI-HQNRDILVNWLVKIHNKFGLLPETLYLAINIMDRFLGKELVQLDKLQLVGTSC 310
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQQPDInPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTC 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 6325376    311 LFIASKYEEVYSPSIKHFASETDGACTEDEIKEGEKFILKTLKFNLN 357
Cdd:pfam00134  81 LFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 363-445 2.10e-20

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 85.34  E-value: 2.10e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376     363 NFLRRISKADDYDIQSRTLAKFLLEISLVDFRFIGILPSLCAAAAMFMSRKMLGKGKWDGNLIHYSGGYTKEELAPVCHM 442
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGYFTEEEILRMERL 80


                   ...
gi 6325376     443 IMD 445
Cdd:smart00385  81 LLE 83
 
Name Accession Description Interval E-value
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
8-487 5.92e-154

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 445.37  E-value: 5.92e-154
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376    8 TENSQNTSSSRFLRNVQRLALNNVTNTTFQKSNANNPALTNFKSTLNSVKKEGSRIPQFTRESVSRSTAAQEEKRTlken 87
Cdd:COG5024   1 HSESLQEYHQEISRNVAVQSSKNKPNVKLILQQPEMNILETRSAIVDFLNQLSTVTRLSNGINFHSSKSTKLVVGT---- 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376   88 giqlpknnllddkenqdpssqqfgALTSIKEGRAelpaNISLQESSSAKEIIQHDPlkgvgssTEVVHNSVENEKlhpar 167
Cdd:COG5024  77 ------------------------CLWLAKKTWG----IISSGESNERARIPRLSE-------CNLDSILFIQMT----- 116

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  168 sQLQVRNTESETDSGKKRPISTIVEQELPKKFKVCD---ENGKEEYEWEDLDAEDVNDPFMVSEYVNDIFEYLHQLEVIT 244
Cdd:COG5024 117 -LNEDSYEPMIDYILKKDENSLSPYELDENQLALDEkqaESKRESQSWQDLDATDQEDPLMVPEYASDIFEYLLKLELID 195

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  245 LPKKEDLYQHRNIH-QNRDILVNWLVKIHNKFGLLPETLYLAINIMDRFLGKELVQLDKLQLVGTSCLFIASKYEEVYSP 323
Cdd:COG5024 196 LPNPNYLIKQSLYEwSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEKYQLVGISALFIASKYEEVNCP 275

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  324 SIKHFASETDGACTEDEIKEGEKFILKTLKFNLNYPNPMNFLRRISKADDYDIQSRTLAKFLLEISLVDFRFIGILPSLC 403
Cdd:COG5024 276 SIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKASDYDIFSRTPAKFSSEISPVDYKFIQISPSWC 355

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  404 AAAAMFMSRKMLGKGKWDGNLIHYSGGYTKEELAPVCHMIMDYLVSPIVH-DEFHRKYQSRRFMKASIISVQWALKVRKN 482
Cdd:COG5024 356 AAAAMYLSRKILSQNQWDRTLIHYSGNYTNPDLKPLNESNKENLQNPSVHhDAIFPKYPSPTFGKASSPTGEWIRSNSSN 435


                ....*
gi 6325376  483 GYDIM 487
Cdd:COG5024 436 DSSLL 440
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 222-354 7.14e-81

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 247.21  E-value: 7.14e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  222 DPFMVSEYVNDIFEYLHQLEVITLPKKEDLY-QHRNIHQNRDILVNWLVKIHNKFGLLPETLYLAINIMDRFLGKELVQL 300
Cdd:cd20568   1 DPLMVAEYVPEIFEYLRELELKTLPNPNYMDdQKELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLSKRVVSL 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 6325376  301 DKLQLVGTSCLFIASKYEEVYSPSIKHFASETDGACTEDEIKEGEKFILKTLKF 354
Cdd:cd20568  81 NKLQLVGISALFIASKYEEVNSPSIKNFAYMTDGAYTVEDILRAERYMLNTLEF 134
CYCLIN_CLBs_yeast_rpt2 cd20512
second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae ...
 360-475 2.26e-64

second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410216  Cd Length: 116  Bit Score: 204.00  E-value: 2.26e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  360 NPMNFLRRISKADDYDIQSRTLAKFLLEISLVDFRFIGILPSLCAAAAMFMSRKMLGKGKWDGNLIHYSgGYTKEELAPV 439
Cdd:cd20512   1 NPMNFLRRISKADDYDIQTRTLAKYLLEITILDHRFLGYPPSLLAAAAMYLARKMLGRGDWNDNLVHYS-GYTESQLIPC 79

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 6325376  440 CHMIMDYLVSPIVH-DEFHRKYQSRRFMKASIISVQW 475
Cdd:cd20512  80 ADIMLEYLVKPIKHhDAFFKKYSSKKFLKASIFVRDW 116
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 226-354 2.02e-63

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 201.99  E-value: 2.02e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  226 VSEYVNDIFEYLHQLEVITLPKKEDLYQHRNI-HQNRDILVNWLVKIHNKFGLLPETLYLAINIMDRFLGKELVQLDKLQ 304
Cdd:cd20507   1 VSEYVKDIYKYLRQLEKKYAIDPDYLSGQPEItERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKKLQ 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 6325376  305 LVGTSCLFIASKYEEVYSPSIKHFASETDGACTEDEIKEGEKFILKTLKF 354
Cdd:cd20507  81 LVGVTALLIASKYEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLDF 130
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 232-357 3.81e-54

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 177.71  E-value: 3.81e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376    232 DIFEYLHQLEVITLPKKEDLYQHRNI-HQNRDILVNWLVKIHNKFGLLPETLYLAINIMDRFLGKELVQLDKLQLVGTSC 310
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQQPDInPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTC 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 6325376    311 LFIASKYEEVYSPSIKHFASETDGACTEDEIKEGEKFILKTLKFNLN 357
Cdd:pfam00134  81 LFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 214-354 4.45e-40

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 141.33  E-value: 4.45e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  214 DLDAEDVNDPFMVSEYVNDIFEYLHQLEVITLPKKEDLYQHRNIHQN-RDILVNWLVKIHNKFGLLPETLYLAINIMDRF 292
Cdd:cd20567   6 DIDEVDKNNPLAAVEYVEDIYSFYRKVEPESCVPPYYMSQQPDINEKmRAILIDWLIEVHLKFELMPETLYLTVNLIDRF 85

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6325376  293 LGKELVQLDKLQLVGTSCLFIASKYEEVYSPSIKHFASETDGACTEDEIKEGEKFILKTLKF 354
Cdd:cd20567  86 LSVKQVPRKELQLVGVTAMLIASKYEEIWAPEVNDFVYISDNAYTRKQILVMEKTMLNTLEF 147
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 359-472 5.12e-40

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 140.07  E-value: 5.12e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376    359 PNPMNFLRRISKADDY--DIQSRTLAKFLLEISLVDFRFIGILPSLCAAAAMFMSRKMLGKGKWDGNLIHYSgGYTKEEL 436
Cdd:pfam02984   1 PTPLSFLRRFSKAADYlhDLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLNSPEWTETLEHYT-GYSEEDL 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 6325376    437 APVCHMIMDYLVSP--IVHDEFHRKYQSRRFMKASIIS 472
Cdd:pfam02984  80 KPCVKLLLELLLNApsSKLQAVRRKYSSSKFMKVSTLP 117
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 228-354 1.61e-36

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 131.22  E-value: 1.61e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  228 EYVNDIFEYLHQLEVITLPKKEDLYQHRNIHQN-RDILVNWLVKIHNKFGLLPETLYLAINIMDRFLGKELVQLDKLQLV 306
Cdd:cd20504   1 EYADDIYEYLRESELKHRPKPDYMRKQPDINPSmRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSKLQLV 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 6325376  307 GTSCLFIASKYEEVYSPSIKHFASETDGACTEDEIKEGEKFILKTLKF 354
Cdd:cd20504  81 GTACMFIAAKYEEIYPPEVEEFVYITDDTYTKKQVLRMEHLVLKVLSF 128
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 222-354 2.45e-36

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 131.14  E-value: 2.45e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  222 DPFMVSEYVNDIFEYLHQLEVITLPKKEDLyQHRNIHQN-RDILVNWLVKIHNKFGLLPETLYLAINIMDRFLGKELVQL 300
Cdd:cd20566   1 NPQLCSDYVKDIYQYLRQLEVQQSIRPHYL-DGKEINERmRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPVSR 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 6325376  301 DKLQLVGTSCLFIASKYEEVYSPSIKHFASETDGACTEDEIKEGEKFILKTLKF 354
Cdd:cd20566  80 KKLQLVGVTALLLASKYEEMYSPEIGDFVYITDNAYTKAQIREMEMLILKELNF 133
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 214-354 2.69e-35

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 128.53  E-value: 2.69e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  214 DLDAEDVNDPFMVSEYVNDIFEYLHQLEViTLPKKEDLYQHRNIHQN-RDILVNWLVKIHNKFGLLPETLYLAINIMDRF 292
Cdd:cd20508   1 DIDEENSDDPFQVSEYAKDIFDYMKEREE-KFVVPDYLEKQTELTPSmRAILVDWLVEVQENFELNHETLYLAVKLVDLY 79

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6325376  293 LGKELVQLDKLQLVGTSCLFIASKYEEVYSPSIKHFASETDGACTEDEIKEGEKFILKTLKF 354
Cdd:cd20508  80 LSKKVVKKEKLQLLGATAILIASKFDERCPPCVDDFLYICDDAYTREELLKMEREILKTLDF 141
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 227-354 2.17e-32

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 119.98  E-value: 2.17e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  227 SEYVNDIFEYLHQLEVITLPKKEDLYQHRNIHQNRDILVNWLVKIHNKFGLLPETLYLAINIMDRFLGKELVQLDKLQLV 306
Cdd:cd20565   2 SEYVKDIYAYLRQLEEEQAVRPKYLEGQEVTGNMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKKMLQLV 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 6325376  307 GTSCLFIASKYEEVYSPSIKHFASETDGACTEDEIKEGEKFILKTLKF 354
Cdd:cd20565  82 GVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALDF 129
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 222-354 4.71e-32

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 119.44  E-value: 4.71e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  222 DPFMVSEYVNDIFEYLHQLEVITLPKKEDLYQ-HRNIHQN-RDILVNWLVKIHNKFGLLPETLYLAINIMDRFLGKELVQ 299
Cdd:cd20562   1 DPQMCSLYATDIYLNLRVAELKRRPLPDYMEKiQRDITPSmRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVN 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6325376  300 LDKLQLVGTSCLFIASKYEEVYSPSIKHFASETDGACTEDEIKEGEKFILKTLKF 354
Cdd:cd20562  81 RQRLQLLGVSCMLIASKYEEICAPQVEEFCYITDNTYTKQEVLEMEIDVLNALQF 135
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 261-352 1.60e-31

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 116.66  E-value: 1.60e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  261 RDILVNWLVKIHNKFGLLPETLYLAINIMDRFLGKELVQLDKLQLVGTSCLFIASKYEEVYSPSIKHFASETDGACTEDE 340
Cdd:cd20536   2 RAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDCFQLLGVTSLLIACKQEEIYPPEVKDLLALCCGAYTREQ 81

                        90
                ....*....|..
gi 6325376  341 IKEGEKFILKTL 352
Cdd:cd20536  82 ICNLECIILTKL 93
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 247-354 6.85e-31

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 116.26  E-value: 6.85e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  247 KKEDLY--------QHRNIHQN-RDILVNWLVKIHNKFGLLPETLYLAINIMDRFLG-KELVQLDKLQLVGTSCLFIASK 316
Cdd:cd20519  14 KKEELYkrdrdflnRHPSLQPRmRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLStQTNVPKTQLQLIGITCLFIAAK 93

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 6325376  317 YEEVYSPSIKHFASETDGACTEDEIKEGEKFILKTLKF 354
Cdd:cd20519  94 LEEIYPPKLSEFAYVTDGACTEDEILTMELIILKALNW 131
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 226-355 4.71e-30

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 114.00  E-value: 4.71e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  226 VSEYVNDIFEYLHQLEVITLPKKEDLYQHRNI-HQNRDILVNWLVKIHNKFGLLPETLYLAINIMDRFLGKELVQLDKLQ 304
Cdd:cd20561   1 VPDYHEDIHTYLREMEVKCKPKVGYMKKQPDItNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQ 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 6325376  305 LVGTSCLFIASKYEEVYSPSIKHFASETDGACTEDEIKEGEKFILKTLKFN 355
Cdd:cd20561  81 LVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFD 131
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 213-355 1.58e-28

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 110.70  E-value: 1.58e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  213 EDLDAEDVnDPFMVSEYVNDIFEYLHQLEVITLPKKEDLYQHRNIHQN-RDILVNWLVKIHNKFGLLPETLYLAINIMDR 291
Cdd:cd20560  21 EDDSAADV-DVLAVPEYAEDIHQYLREAELKHRPKPGYMRKQPDITTGmRTILVDWLVEVGEEYKLQTETLYLAVNYLDR 99

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6325376  292 FLGKELVQLDKLQLVGTSCLFIASKYEEVYSPSIKHFASETDGACTEDEIKEGEKFILKTLKFN 355
Cdd:cd20560 100 FLSCMSVLRGKLQLVGTAAILLASKYEEIYPPEVDEFVYITDDTYTKKQLLRMEHLLLKVLAFD 163
CYCLIN_CCNB1-like_rpt2 cd20509
second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 359-467 1.25e-27

second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410213  Cd Length: 111  Bit Score: 106.54  E-value: 1.25e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  359 PNPMNFLRRISKADDYDIQSRTLAKFLLEISLVDFRFIGILPSLCAAAAMFMSRKMLGKGKWDGNLIHYSgGYTKEELAP 438
Cdd:cd20509   1 PLPLHFLRRFSKAGGADAQKHTLAKYLMELTLLDYDMVHYKPSEIAAAALCLSRKILDEPEWTPTLEHYS-TYSEEDLLP 79

                        90       100       110
                ....*....|....*....|....*....|.
gi 6325376  439 VCHMIMDYLVS--PIVHDEFHRKYQSRRFMK 467
Cdd:cd20509  80 IVQKMAKLVVKsqTSKYQAVKNKYSSSKFMR 110
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 231-354 1.48e-25

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 101.49  E-value: 1.48e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  231 NDIFEYLHQLEVITLPKKEDLYQHRNIHQN-RDILVNWLVKIHNKFGLLPETLYLAINIMDRFLG-KELVQLDKLQLVGT 308
Cdd:cd20579  12 DEVWKNMLNKDKTYLRDKNFLQKHPLLQPKmRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMAtQENVVKTRLQLIGI 91

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 6325376  309 SCLFIASKYEEVYSPSIKHFASETDGACTEDEIKEGEKFILKTLKF 354
Cdd:cd20579  92 SSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALKW 137
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 261-356 1.29e-24

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 97.39  E-value: 1.29e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  261 RDILVNWLVKIHNKFGLLPETLYLAINIMDRFLGKELVQLDKLQLVGTSCLFIASKYEEVYSPSIKHFASETDGACTEDE 340
Cdd:cd20542   1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLLQLLGITCLFIACKFEERFPPEVATLCYLTDDSYSKKQ 80

                        90
                ....*....|....*.
gi 6325376  341 IKEGEKFILKTLKFNL 356
Cdd:cd20542  81 VLRMERRVLRRLRFDL 96
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 247-354 2.28e-23

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 95.68  E-value: 2.28e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  247 KKEDLYQH-RNIHQN--------RDILVNWLVKIHNKFGLLPETLYLAINIMDRF-LGKELVQLDKLQLVGTSCLFIASK 316
Cdd:cd20580  20 KKESKYVHdKHFLQLhpalqpkmRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKNINKSMLQLIGITSLFIASK 99

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 6325376  317 YEEVYSPSIKHFASETDGACTEDEIKEGEKFILKTLKF 354
Cdd:cd20580 100 LEEIYPPKLHEFAYVTDGACSEDDILDMELIILKALKW 137
CYCLIN_CCNB2_rpt2 cd20570
second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 ...
 359-472 3.86e-22

second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410273  Cd Length: 119  Bit Score: 91.48  E-value: 3.86e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  359 PNPMNFLRRISKADDYDIQSRTLAKFLLEISLVDFRFIGILPSLCAAAAMFMSRKMLGKGKWDGNLIHYSgGYTKEELAP 438
Cdd:cd20570   1 PLPLHFLRRASKAGSADVEKHTLAKYLMELTLIDYDMVHYHPSEIAAAALCLSQKVLDGGKWSLTQQYYT-GYTEDDLKP 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 6325376  439 vchmIMDYLVSPIV--------HDEFHRKYQSRRFMKASIIS 472
Cdd:cd20570  80 ----IMQHMAKNVVkvnegltkHVAVKNKYASSKLMKISTIP 117
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 363-445 2.10e-20

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 85.34  E-value: 2.10e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376     363 NFLRRISKADDYDIQSRTLAKFLLEISLVDFRFIGILPSLCAAAAMFMSRKMLGKGKWDGNLIHYSGGYTKEELAPVCHM 442
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGYFTEEEILRMERL 80


                   ...
gi 6325376     443 IMD 445
Cdd:smart00385  81 LLE 83
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 266-350 2.63e-20

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 84.95  E-value: 2.63e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376     266 NWLVKIHNKFGLLPETLYLAINIMDRFLGKELVQLDKLQLVGTSCLFIASKYEEVYSPSIKHFASETDgaCTEDEIKEGE 345
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRME 78


                   ....*
gi 6325376     346 KFILK 350
Cdd:smart00385  79 RLLLE 83
CYCLIN_CCNB3_rpt2 cd20510
second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 ...
 359-442 2.72e-19

second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410214  Cd Length: 115  Bit Score: 83.10  E-value: 2.72e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  359 PNPMNFLRRISKADDYDIQSRTLAKFLLEISLVDFRFIGILPSLCAAAAMFMSRKMLGKGKWDGNLIHYSgGYTKEELAP 438
Cdd:cd20510   1 PLSYRFLRRYAKCARASMETLTLARYILELSLMEYQFVQERASKLAAAALLLALKMKNLGEWTPTLEYYS-GYSAEDLLP 79


                ....*
gi 6325376  439 -VCHM 442
Cdd:cd20510  80 lVRKL 84
CYCLIN_CCNB1_rpt2 cd20569
second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 ...
 359-472 1.65e-18

second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410272  Cd Length: 121  Bit Score: 81.48  E-value: 1.65e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  359 PNPMNFLRRISKADDYDIQSRTLAKFLLEISLVDFRFIGILPSLCAAAAMFMSRKMLGKGKWDGNLIHYSgGYTKEELAP 438
Cdd:cd20569   1 PLPLHFLRRASKIGEVDVEQHTLAKYLMELTMVDYDMVHFPPSQIAAAAFCLALKILDNGEWTPTLQHYM-SYTEESLLP 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 6325376  439 VchmiMDYLVSPIV--------HDEFHRKYQSRRFMKASIIS 472
Cdd:cd20569  80 V----MQHMAKNVVkvnqgltkHMTVKNKYASSKQMKISTLP 117
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 359-447 5.33e-18

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 78.89  E-value: 5.33e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  359 PNPMNFLRRISKADDYDIQSRTLAKFLLEISLVDFRFIGILPSLCAAAAMFMSRKMLGKGKWDGNLIHYSGGYTKEELAP 438
Cdd:cd20537   1 PTPLSFLRRYLSLLGLDEKVRHLARYLLELSLLDYEFLKYRPSLIAAAALYLARKILGEPPPSPQLLQLVTGYSENDLQE 80


                ....*....
gi 6325376  439 VCHMIMDYL 447
Cdd:cd20537  81 CAKELLELL 89
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 260-356 4.00e-17

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 76.58  E-value: 4.00e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  260 NRDILVNWLVKIHNKFGLLPETLYLAINIMDRFLGKELVQLDKLQLVGTSCLFIASKY--EEVYSPSIKHFASETDGACT 337
Cdd:cd20526   1 QRDEAVRWLAELNSQFKFYPETFALAVSILDRFLASVKARPKYLRCIAISCLFLAAKTneEDEVIPSTKDLVRVSKCGCS 80

                        90
                ....*....|....*....
gi 6325376  338 EDEIKEGEKFILKTLKFNL 356
Cdd:cd20526  81 VAEVLRMERIILDKLHWDL 99
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 264-355 2.95e-16

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 73.96  E-value: 2.95e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  264 LVNWLVKIHNKFGLLPETLYLAINIMDRFLGKELVQLDKLQLVGTSCLFIASKYEEVYS--PSIKHFASETDGACTEDEI 341
Cdd:cd20559   2 LLDFLFELHVELRLSPQTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWESKArvPLLSELSKMCCNSYGEELF 81

                        90
                ....*....|....
gi 6325376  342 KEGEKFILKTLKFN 355
Cdd:cd20559  82 IQMEMHILNTLNWD 95
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 260-353 7.16e-16

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 73.12  E-value: 7.16e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  260 NRDILVNWLVKIHNKFGLLPETLYLAINIMDRFLGKELVQLDK---LQLVGTSCLFIASKYEEVYSPSIKHFASETDGA- 335
Cdd:cd20543   1 VRNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKDKpwmLQLLAVACLSLAAKMEETDVPLLVDLQVEEPKYv 80

                        90
                ....*....|....*...
gi 6325376  336 CTEDEIKEGEKFILKTLK 353
Cdd:cd20543  81 FEAKTIQRMELLVLSTLE 98
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 264-346 2.04e-15

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 71.29  E-value: 2.04e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  264 LVNWLVKIHNKFGLLPETLYLAINIMDRFLGKELVQLDKLQLVGTSCLFIASKYEEvYSPSIKHFASETDgaCTEDEIKE 343
Cdd:cd00043   2 AVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEE-LPRTLKEIAKVSG--VSEKELRK 78


                ...
gi 6325376  344 GEK 346
Cdd:cd00043  79 AEK 81
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 359-465 8.07e-15

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410210  Cd Length: 111  Bit Score: 70.36  E-value: 8.07e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  359 PNPMNFLRRISKA---DDYDIQSRTLAKFLLEISLVDFRFIGILPSLCAAAAMFMSRKMLGKGKWDGNLIHYSgGYTKEE 435
Cdd:cd20506   1 PTIKTFLRRFLRAaqaSVPDLKLEFLANYLAELSLLDYEFLKYLPSLIAASAVFLARHTLNPHPWNPTLEHYT-GYKAAD 79

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 6325376  436 LAPVCHMIMDYLVS------PIVHDefhrKYQSRRF 465
Cdd:cd20506  80 LKPCVQALHDLQLNasgsslQAVRE----KYKQHKF 111
CYCLIN_AtCycB-like_rpt2 cd20511
second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 359-472 1.00e-12

second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410215  Cd Length: 117  Bit Score: 64.63  E-value: 1.00e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  359 PNPMNFLRRISKADDYDIQSRTLAKFLLEISLVDFRFIGILPSLCAAAAMFMSRKMLGK-GKWDGNLIHYSgGYTKEELA 437
Cdd:cd20511   1 PTPYVFLVRFLKAAQSDKKLENLAFFLVELGLVEYEMLKYSPSMLAASAVYTARCTLNKtPEWTSTLEFHT-GYSESQLM 79

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 6325376  438 PVCHMIMdYLVSPIVHDEF---HRKYQSRRFMKASIIS 472
Cdd:cd20511  80 ECARLMV-RLHSKAGTGKLtavYKKYSSSKFGAVALLP 116
CYCLIN_CCNG cd20523
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ...
 261-352 8.60e-12

cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410227  Cd Length: 94  Bit Score: 61.21  E-value: 8.60e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  261 RDILVNWLVKIHNKFGLLPETLYLAINIMDRFLGKELVQLDKLQLVGTSCLFIASKY--EEVYSPSIKHFASETDGACTE 338
Cdd:cd20523   1 RDAAVDRLRCLHRFYGFSPETFALAVNLLDRFLSKVKVKPKHLACITVSCFHIAIKSveEDQNIPSAEDLIRISQCGCTA 80

                        90
                ....*....|....
gi 6325376  339 DEIKEGEKFILKTL 352
Cdd:cd20523  81 ADLMRMEGIILEKL 94
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 284-355 9.38e-12

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 62.70  E-value: 9.38e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6325376  284 LAINIMDRFLGKELVQLDKLQLVGTSCLFIASKYEEVYSPSIKHFASETDGACTEDEIKEGEKFILKTLKFN 355
Cdd:cd20515  79 LAVNYLDRFLSLVPIRKSQLQLLGAVCLFLASKLKETIPLTAEKLCIYTDNSITLQELLDWELLVLTKLKWD 150
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 261-354 5.82e-11

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 59.15  E-value: 5.82e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  261 RDILVNWLVKIHNKFGLLPETLYLAINIMDRFLGKELVQLDKLQLVGTSCLFIASKYEEVYS--PSIKHFASETD-GACT 337
Cdd:cd20528   7 RRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQLHLVALTCLLLAAKFEELDDniPKISDLNRYLCnSVYS 86

                        90
                ....*....|....*..
gi 6325376  338 EDEIKEGEKFILKTLKF 354
Cdd:cd20528  87 KQEYLQMELLILEFFQW 103
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 261-355 7.58e-11

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 60.38  E-value: 7.58e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  261 RDILVNWLVKIHNKFGLLPETLYLAINIMDRFLGKELVQLDKLQLVGTSCLFIASKYEEVYSPSIKHFASETDGACTEDE 340
Cdd:cd20573  55 RKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEPTKKSRLQLLGATCMFLASKMKETIPLTAEKLCIYTDNSIRPEE 134

                        90
                ....*....|....*
gi 6325376  341 IKEGEKFILKTLKFN 355
Cdd:cd20573 135 LLQMELLVLNKLKWD 149
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 261-341 7.72e-11

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 58.48  E-value: 7.72e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  261 RDILVNWLVKIHNKFGLLPETLYLAINIMDRFLGKELVQLDKLQLVGTSCLFIASKYEEVYSPSIKHFASETDGACTEDE 340
Cdd:cd20521   4 RYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRKVPRSKLQLLGIACMVIATRFLGKDILTIREAAWLTDNTYKYED 83


                .
gi 6325376  341 I 341
Cdd:cd20521  84 V 84
CYCLIN_CCNJ-like_rpt2 cd20529
second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 359-443 4.56e-10

second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410232 [Multi-domain]  Cd Length: 101  Bit Score: 56.60  E-value: 4.56e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  359 PNPMNFLRR-----ISKADDYDIQSRTL-----------AKFLLEISLVDFRFIGILPSLCAAAAMFMSRKMLG-KGKWD 421
Cdd:cd20529   1 PTPAHFLEYylsqgVLFVDDHDGLPSELlekvkeyvrkyADFFLDLSLQDYAFLNYKPSLLAAACIAAARKALGlSPTWP 80

                        90       100
                ....*....|....*....|..
gi 6325376  422 GNLIHYSgGYTKEELAPVCHMI 443
Cdd:cd20529  81 EELEKLT-GYSEDELEPCVELL 101
CYCLIN_CCNA_rpt2 cd20505
second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 359-466 1.25e-09

second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410209 [Multi-domain]  Cd Length: 110  Bit Score: 55.76  E-value: 1.25e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  359 PNPMNFLRRISKADDYDIQSRTLAKFLLEISLVDFR-FIGILPSLCAAAAMFMSRKMLGKGKWDGNLIHYSgGYTKEELA 437
Cdd:cd20505   1 PTSNWFLERFLKHSNADEKTKSLAMYLCELSLIDADpYLKYLPSVIAAAAVCLANHTLGNEVWPQKLARST-GYSLEDLL 79

                        90       100       110
                ....*....|....*....|....*....|.
gi 6325376  438 PVCHMIMDYLVSPIVHDE--FHRKYQSRRFM 466
Cdd:cd20505  80 PCLRDLHRTFLNAPSSPQqaIREKYKSSKYH 110
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 261-355 2.01e-09

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 56.15  E-value: 2.01e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  261 RDILVNWLVKIHNKFGLLPETLYLAINIMDRFLGKELVQLDKLQLVGTSCLFIASKYEEVYSPSIKHFASETDGACTEDE 340
Cdd:cd20575  56 RKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDNSISPRQ 135

                        90
                ....*....|....*
gi 6325376  341 IKEGEKFILKTLKFN 355
Cdd:cd20575 136 LLDWEILVLGKLKWD 150
CYCLIN_vCyC_rpt1 cd20517
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 259-354 4.36e-09

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410221  Cd Length: 99  Bit Score: 53.72  E-value: 4.36e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  259 QNRDILVNWLVKIHNKFGLLPETLYLAINIMDRFLGKELVQLDKLQLVGTSCLFIASKYEEVYSPSIKHFASETDGACTE 338
Cdd:cd20517   4 DNRKILLTWMFLVCESFELDKNVFPLAVSLLDRLLLKKQGTKETLQKTGAACLLIASKIRTVKPITVSKLTYLSCDCFTN 83

                        90
                ....*....|....*.
gi 6325376  339 DEIKEGEKFILKTLKF 354
Cdd:cd20517  84 LELINQEKDILEALKW 99
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 261-355 4.54e-08

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 52.30  E-value: 4.54e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  261 RDILVNWLVKIHNKFGLLPETLYLAINIMDRFLGKELVQLDKLQLVGTSCLFIASKYEEVYSPSIKHFASETDGACTEDE 340
Cdd:cd20574  56 RRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAVVPTRKCHLQLLGAVCMFLASKLKETIPLTAEKLCIYTDNSIKPQE 135

                        90
                ....*....|....*
gi 6325376  341 IKEGEKFILKTLKFN 355
Cdd:cd20574 136 LLEWELVVLGKLKWN 150
CYCLIN_CCNG2 cd20584
cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth ...
 261-352 1.67e-07

cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. CCNG2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410287  Cd Length: 96  Bit Score: 49.07  E-value: 1.67e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  261 RDILVNWLVKIHNKFGLLPETLYLAINIMDRFLGKELVQLDKLQLVGTSCLFIASKY--EEVYSPSIKHFASETDGACTE 338
Cdd:cd20584   2 RDAKVEDLWSLTNFFGFSTETFVLAVNILDRFLALMKVKPKHLSCIGICCFHLAARVveEECNIPSSHDLIRISQCKCTV 81

                        90
                ....*....|....
gi 6325376  339 DEIKEGEKFILKTL 352
Cdd:cd20584  82 SDLKRMEKIISEKL 95
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 261-319 1.31e-06

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410286  Cd Length: 98  Bit Score: 46.74  E-value: 1.31e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6325376  261 RDILVNWLVKIHNKFGLLPETLYLAINIMDRFLGKELVQLDKLQLVGTSCLFIASKYEE 319
Cdd:cd20583   2 RDFEVKDLLSLTQFFGFSTETFSLAVNLLDRFLAKMKVQPKHLGCVGLSCFYLAVKAIE 60
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 360-436 4.68e-06

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 44.71  E-value: 4.68e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6325376  360 NPMNFLRRISKADDYDIQSRTLAKFLLEISLVDFRFIGILPSLCAAAAMFMSRKMLGKGKWDGNLIHYSgGYTKEEL 436
Cdd:cd00043   1 KAVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELPRTLKEIAKVS-GVSEKEL 76
CYCLIN_CCNO_rpt2 cd20722
second cyclin box found in cyclin-O (CCNO); CCNO is specifically required for generation of ...
 377-415 1.00e-04

second cyclin box found in cyclin-O (CCNO); CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410311  Cd Length: 97  Bit Score: 41.18  E-value: 1.00e-04
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 6325376  377 QSRTLAKFLLEISLVDFRFIGILPSLCAAAAMFMSRKML 415
Cdd:cd20722  28 KARALARYLAELSLADYAFNQYPPSLLAICSLELADRML 66
CYCLIN_CCNA2_rpt2 cd20564
second cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1 ...
 380-450 1.42e-04

second cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly overexpressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410267  Cd Length: 110  Bit Score: 41.35  E-value: 1.42e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6325376  380 TLAKFLLEISLVDFR-FIGILPSLCAAAAMFMSRKMLGKGKWDGNLIHYSgGYTKEELAPvChmIMD----YLVSP 450
Cdd:cd20564  22 SLSMFLGELSLIDADpYLKYLPSVIAAAAFHLALYTVTGQSWPESLVQKT-GYTLESLKP-C--LMDlhqtYLKAP 93
CYCLIN_CCNA1_rpt2 cd20563
second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily ...
 359-471 2.06e-04

second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410266  Cd Length: 123  Bit Score: 40.95  E-value: 2.06e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  359 PNPMNFLRRISKADDYDIQSRTLAKFLLEISLVDFR-FIGILPSLCAAAAMFMSRKMLGKGKWDGNLIHYSgGYTKEELA 437
Cdd:cd20563   1 PTINQFLLQYLKRHEVCEKTENLAMYVAELSLLEVDpFLKYLPSLTAAAAYCLANYTVNKVFWPETLAAFT-GYSLSEIV 79

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 6325376  438 PvCHMIMDYLVSPIVH---DEFHRKYQSRRFMKASII 471
Cdd:cd20563  80 P-CLSDLHKACLGAPHrpqQAIREKYKGSKYMQVSLL 115
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 280-420 9.07e-04

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 41.26  E-value: 9.07e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  280 ETLYLAINIMDRFLGKELVQLDKLQLVGTSCLFIASKYEEV-YSPSIKHFASETDG----ACTEDEIKEGEKFILKTLKF 354
Cdd:COG5333  64 TVLATAILFFSRFYLKNSVEEISLYSVVTTCVYLACKVEDTpRDISIESFEARDLWseepKSSRERILEYEFELLEALDF 143

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6325376  355 NLNYPNPMNFL-------RRISKADDYDIQSrtlaKFLLEISLVDFRFIgILPSLCAAAAMFMSRKMLGKGKW 420
Cdd:COG5333 144 DLHVHHPYKYLegflkdlQEKDKYKLLQIAW----KIINDALRTDLCLL-YPPHIIALAALLIACEVLGMPII 211
Caldesmon pfam02029
Caldesmon;
55-211 3.32e-03

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 39.85  E-value: 3.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376     55 SVKKEGSRIPQFTRESVSRSTAAQEEKRTLKENGIQLPKNNLLDDKENQDPSSQQFGALTSIKEGRAELPANISLQESSS 134
Cdd:pfam02029  35 SVEPNEHNSYEEDSELKPSGQGGLDEEEAFLDRTAKREERRQKRLQEALERQKEFDPTIADEKESVAERKENNEEEENSS 114

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6325376    135 AKEIIQHDPLKGVGS--STEVVHNSVENEKLHPARSQLQVRNTESEtdsgKKRPISTIVEQELPKKFKVCDENGKEEYE 211
Cdd:pfam02029 115 WEKEEKRDSRLGRYKeeETEIREKEYQENKWSTEVRQAEEEGEEEE----DKSEEAEEVPTENFAKEEVKDEKIKKEKK 189
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 262-356 9.24e-03

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 36.81  E-value: 9.24e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325376  262 DILVNW----LVKIHNKFGLLPETLYLAINIMDRF-LGKELVQLDKLQLVGTsCLFIASKYEEvYSPSIKHFASETDGA- 335
Cdd:cd20524  52 LLLVRYyekkLLEFCRAFKLPDSVLATALTYFKRFyLKNSVMEYHPKEIMLT-CLYLACKVEE-FNISIDQFVGNIKESe 129

                        90       100
                ....*....|....*....|.
gi 6325376  336 CTEDEIKEGEKFILKTLKFNL 356
Cdd:cd20524 130 KTAEIILEYELLLLQGLNFHL 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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