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Conserved domains on  [gi|6325446|ref|NP_015514|]
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Mlc2p [Saccharomyces cerevisiae S288C]

Protein Classification

EF-hand domain-containing protein( domain architecture ID 1000080)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00184 super family cl33172
calmodulin; Provisional
 10-109 5.85e-08

calmodulin; Provisional


The actual alignment was detected with superfamily member PTZ00184:

Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 48.99  E-value: 5.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325446    10 NQLTQDYINKLKDAFQMLDEDEDGLISRGDLTKIYATLGKTLTDEEWSKMVPDNDTStaevGEEGVSFPIFLSIMGKNLS 89
Cdd:PTZ00184   3 DQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDAD----GNGTIDFPEFLTLMARKMK 78

                         90       100
                 ....*....|....*....|
gi 6325446    90 QFPEREELEESLKAIGRGHD 109
Cdd:PTZ00184  79 DTDSEEEIKEAFKVFDRDGN 98
 
Name Accession Description Interval E-value
PTZ00184 PTZ00184
calmodulin; Provisional
 10-109 5.85e-08

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 48.99  E-value: 5.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325446    10 NQLTQDYINKLKDAFQMLDEDEDGLISRGDLTKIYATLGKTLTDEEWSKMVPDNDTStaevGEEGVSFPIFLSIMGKNLS 89
Cdd:PTZ00184   3 DQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDAD----GNGTIDFPEFLTLMARKMK 78

                         90       100
                 ....*....|....*....|
gi 6325446    90 QFPEREELEESLKAIGRGHD 109
Cdd:PTZ00184  79 DTDSEEEIKEAFKVFDRDGN 98
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 19-65 3.62e-04

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 37.14  E-value: 3.62e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 6325446   19 KLKDAFQMLDEDEDGLISRGDLTKIYATLGKTLTDEEWSKMVPDNDT 65
Cdd:cd00051   1 ELREAFRLFDKDGDGTISADELKAALKSLGEGLSEEEIDEMIREVDK 47
EF-hand_7 pfam13499
EF-hand domain pair;
17-55 3.64e-03

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 34.54  E-value: 3.64e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 6325446     17 INKLKDAFQMLDEDEDGLISRGDLTKIYATL--GKTLTDEE 55
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKLeeGEPLSDEE 41
 
Name Accession Description Interval E-value
PTZ00184 PTZ00184
calmodulin; Provisional
 10-109 5.85e-08

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 48.99  E-value: 5.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325446    10 NQLTQDYINKLKDAFQMLDEDEDGLISRGDLTKIYATLGKTLTDEEWSKMVPDNDTStaevGEEGVSFPIFLSIMGKNLS 89
Cdd:PTZ00184   3 DQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDAD----GNGTIDFPEFLTLMARKMK 78

                         90       100
                 ....*....|....*....|
gi 6325446    90 QFPEREELEESLKAIGRGHD 109
Cdd:PTZ00184  79 DTDSEEEIKEAFKVFDRDGN 98
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 19-65 3.62e-04

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 37.14  E-value: 3.62e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 6325446   19 KLKDAFQMLDEDEDGLISRGDLTKIYATLGKTLTDEEWSKMVPDNDT 65
Cdd:cd00051   1 ELREAFRLFDKDGDGTISADELKAALKSLGEGLSEEEIDEMIREVDK 47
PTZ00183 PTZ00183
centrin; Provisional
 23-86 4.27e-04

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 38.52  E-value: 4.27e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6325446    23 AFQMLDEDEDGLISRGDLTKIYATLGKTLTDEEWSKMVPDNDTStaevGEEGVSFPIFLSIMGK 86
Cdd:PTZ00183  95 AFRLFDDDKTGKISLKNLKRVAKELGETITDEELQEMIDEADRN----GDGEISEEEFYRIMKK 154
PTZ00184 PTZ00184
calmodulin; Provisional
 14-84 2.52e-03

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 36.28  E-value: 2.52e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6325446    14 QDYINKLKDAFQMLDEDEDGLISRGDLTKIYATLGKTLTDEEWSKMVPDNDTStaevGEEGVSFPIFLSIM 84
Cdd:PTZ00184  80 TDSEEEIKEAFKVFDRDGNGFISAAELRHVMTNLGEKLTDEEVDEMIREADVD----GDGQINYEEFVKMM 146
EF-hand_7 pfam13499
EF-hand domain pair;
17-55 3.64e-03

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 34.54  E-value: 3.64e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 6325446     17 INKLKDAFQMLDEDEDGLISRGDLTKIYATL--GKTLTDEE 55
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKLeeGEPLSDEE 41
PTZ00183 PTZ00183
centrin; Provisional
 10-103 4.25e-03

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 35.82  E-value: 4.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6325446    10 NQLTQDYINKLKDAFQMLDEDEDGLISRGDLTKIYATLGKTLTDEEWSKMVPDNDTStaevGEEGVSFPIFLSIMGKNLS 89
Cdd:PTZ00183   9 PGLTEDQKKEIREAFDLFDTDGSGTIDPKELKVAMRSLGFEPKKEEIKQMIADVDKD----GSGKIDFEEFLDIMTKKLG 84

                         90
                 ....*....|....
gi 6325446    90 qfpEREELEESLKA 103
Cdd:PTZ00183  85 ---ERDPREEILKA 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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