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Conserved domains on  [gi|45269141|ref|NP_031377|]
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multimerin-1 isoform 1 precursor [Homo sapiens]

Protein Classification

calcium-binding EGF-like domain-containing protein( domain architecture ID 13728361)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
C1q super family cl23878
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement ...
 1094-1228 6.27e-45

C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement system.


The actual alignment was detected with superfamily member smart00110:

Pssm-ID: 420072  Cd Length: 135  Bit Score: 158.62  E-value: 6.27e-45
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    1094 SYRYAPMVAFFASHTygMTIPG---PILFNNLDVNYGASYTPRTGKFRIPYLGVYVFKYTIESFSAHISGFLVVDGIDKL 1170
Cdd:smart00110    1 NYKAQPRSAFSVIRS--NRPPPpgqPIRFDKVLYNQQGHYDPRTGKFTCPVPGVYYFSYHVESKGRNVKVSLMKNGIQVM 78

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    1171 afeSENINSEIHCDRVLTGDALLELNYGQEVWLRL--AKGTIPAKFPPVTTFSGYLLYRT 1228
Cdd:smart00110   79 ---STYDEYQKGLYDVASGGALLQLRQGDQVWLELpdEKNGLYAGEYVDSTFSGFLLFPD 135
EMI pfam07546
EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final ...
 208-277 5.28e-15

EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.


:

Pssm-ID: 462204  Cd Length: 69  Bit Score: 70.91  E-value: 5.28e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 45269141    208 KNWCAYvhtRLSPTVILDNQVTYV----PGGKGPCGWTGgSCPQRsQKISNPVYRMQHKIVTSLDWRCCPGYSG 277
Cdd:pfam07546    1 RNVCAY---KVVSCVVVTGTESYVqpvyKPYLTWCAGHR-RCSTY-RTTYRPAYRQVYKTVTRLEWRCCPGWGG 69
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1045-1077 2.95e-11

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 59.19  E-value: 2.95e-11
                         10        20        30
                 ....*....|....*....|....*....|....
gi 45269141 1045 C-SRHPCQNGGTCINGRTSFTCACRHPFTGDNCT 1077
Cdd:cd00054    5 CaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
CCDC158 super family cl37899
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 296-743 1.24e-07

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


The actual alignment was detected with superfamily member pfam15921:

Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 56.28  E-value: 1.24e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    296 AESHTAVGRGVAEQQQQQGCGDPEVMQKMTDQVNYQAMKLTLlqKKIDNISLTVNDVRN--TYSSLEGKVsEDKSREFQ- 372
Cdd:pfam15921  354 ANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSL--EKEQNKRLWDRDTGNsiTIDHLRREL-DDRNMEVQr 430

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    373 --SLLKGLKSKSINVLIRDIVREQFKifqNDMQETVaqlfktvSSLSEDLESTRQIIQKVNESV----VSIAAQQKFV-- 444
Cdd:pfam15921  431 leALLKAMKSECQGQMERQMAAIQGK---NESLEKV-------SSLTAQLESTKEMLRKVVEELtakkMTLESSERTVsd 500

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    445 ----LVQENR---PTLTDIVELR-----------------NHIVNVRQE---MTLTCEKPIKELEVKQTHLEGALE--QE 495
Cdd:pfam15921  501 ltasLQEKERaieATNAEITKLRsrvdlklqelqhlknegDHLRNVQTEceaLKLQMAEKDKVIEILRQQIENMTQlvGQ 580

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    496 HSRSILYYESLNKTLSklKEVHEQLLSTEQ---VSDQKNAPAAE---SVSNNVTEYMSTLH---------ENIKKQSlmm 560
Cdd:pfam15921  581 HGRTAGAMQVEKAQLE--KEINDRRLELQEfkiLKDKKDAKIREleaRVSDLELEKVKLVNagserlravKDIKQER--- 655

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    561 LQMFEDLHIQESKINNLTVSLEMEKESLRGECEDMlSKCRNDFKFQLKDTEENLHVLNQTL----------AEVLFPMDN 630
Cdd:pfam15921  656 DQLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEEM-ETTTNKLKMQLKSAQSELEQTRNTLksmegsdghaMKVAMGMQK 734

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    631 KMDKMSEQLNDLTYDMEILQPLLEQGASLRQTMTYEQPKEAivirkkiENLTSAVNSLNFIIKELtkrhNLLRNEvqgrd 710
Cdd:pfam15921  735 QITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKNKLS-------QELSTVATEKNKMAGEL----EVLRSQ----- 798

                          490       500       510
                   ....*....|....*....|....*....|...
gi 45269141    711 dalERRINEYALEMEDGLNKTMTIINNAIDFIQ 743
Cdd:pfam15921  799 ---ERRLKEKVANMEVALDKASLQFAECQDIIQ 828
235kDa-fam super family cl31124
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 676-873 6.14e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


The actual alignment was detected with superfamily member TIGR01612:

Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 41.19  E-value: 6.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    676 KKIENLTSAVNSLNFIIKELTKRHNLLRNEVQGRDDALERRINEYALEmEDGLNKTMTIINN---------AIDFIQD-- 744
Cdd:TIGR01612  730 KKNELLDIIVEIKKHIHGEINKDLNKILEDFKNKEKELSNKINDYAKE-KDELNKYKSKISEiknhyndqiNIDNIKDed 808

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    745 ---NY-ALKETLSTIKDNSEIHHKCTSDM----ETILTFIPQFHRLNDSIQTLVNDNQRyNFVLQVAKTLAGIpRDEKLN 816
Cdd:TIGR01612  809 akqNYdKSKEYIKTISIKEDEIFKIINEMkfmkDDFLNKVDKFINFENNCKEKIDSEHE-QFAELTNKIKAEI-SDDKLN 886

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 45269141    817 --QSNFQKMYQMFNETTSQVRKYQQNMSHLEE-----KLLLTTKIS-KNFETRLQDIESKVTQTL 873
Cdd:TIGR01612  887 dyEKKFNDSKSLINEINKSIEEEYQNINTLKKvdeyiKICENTKESiEKFHNKQNILKEILNKNI 951
 
Name Accession Description Interval E-value
C1Q smart00110
Complement component C1q domain; Globular domain found in many collagens and eponymously in ...
 1094-1228 6.27e-45

Complement component C1q domain; Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tumour necrosis factor.


Pssm-ID: 128420  Cd Length: 135  Bit Score: 158.62  E-value: 6.27e-45
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    1094 SYRYAPMVAFFASHTygMTIPG---PILFNNLDVNYGASYTPRTGKFRIPYLGVYVFKYTIESFSAHISGFLVVDGIDKL 1170
Cdd:smart00110    1 NYKAQPRSAFSVIRS--NRPPPpgqPIRFDKVLYNQQGHYDPRTGKFTCPVPGVYYFSYHVESKGRNVKVSLMKNGIQVM 78

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    1171 afeSENINSEIHCDRVLTGDALLELNYGQEVWLRL--AKGTIPAKFPPVTTFSGYLLYRT 1228
Cdd:smart00110   79 ---STYDEYQKGLYDVASGGALLQLRQGDQVWLELpdEKNGLYAGEYVDSTFSGFLLFPD 135
C1q pfam00386
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement ...
 1102-1225 2.57e-35

C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement system.


Pssm-ID: 395310 [Multi-domain]  Cd Length: 126  Bit Score: 130.87  E-value: 2.57e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   1102 AFFASHTYGMTIPG--PILFNNLDVNYGASYTPRTGKFRIPYLGVYVFKYTIES-FSAHISGFLVVDGIDKLAFESENIN 1178
Cdd:pfam00386    1 AFSAGRTTGLTAPNeqPVRFDKVLTNIGGHYDPATGKFTCPVPGVYYFSYHITTvDGKSLYVSLVKNGQEVVSFYDQPQK 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 45269141   1179 SEihcDRVLTGDALLELNYGQEVWLRLA--KGTIPAKFPPVTTFSGYLL 1225
Cdd:pfam00386   81 GS---LDVASGSVVLELQRGDEVWLQLTgyNGLYYDGSDTDSTFSGFLL 126
EMI pfam07546
EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final ...
 208-277 5.28e-15

EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.


Pssm-ID: 462204  Cd Length: 69  Bit Score: 70.91  E-value: 5.28e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 45269141    208 KNWCAYvhtRLSPTVILDNQVTYV----PGGKGPCGWTGgSCPQRsQKISNPVYRMQHKIVTSLDWRCCPGYSG 277
Cdd:pfam07546    1 RNVCAY---KVVSCVVVTGTESYVqpvyKPYLTWCAGHR-RCSTY-RTTYRPAYRQVYKTVTRLEWRCCPGWGG 69
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1045-1077 2.95e-11

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 59.19  E-value: 2.95e-11
                         10        20        30
                 ....*....|....*....|....*....|....
gi 45269141 1045 C-SRHPCQNGGTCINGRTSFTCACRHPFTGDNCT 1077
Cdd:cd00054    5 CaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1045-1075 8.63e-10

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 54.70  E-value: 8.63e-10
                           10        20        30
                   ....*....|....*....|....*....|.
gi 45269141   1045 CSRHPCQNGGTCINGRTSFTCACRHPFTGDN 1075
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
1045-1077 1.73e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 51.48  E-value: 1.73e-08
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 45269141    1045 C-SRHPCQNGGTCINGRTSFTCACRHPFT-GDNCT 1077
Cdd:smart00179    5 CaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 296-743 1.24e-07

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 56.28  E-value: 1.24e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    296 AESHTAVGRGVAEQQQQQGCGDPEVMQKMTDQVNYQAMKLTLlqKKIDNISLTVNDVRN--TYSSLEGKVsEDKSREFQ- 372
Cdd:pfam15921  354 ANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSL--EKEQNKRLWDRDTGNsiTIDHLRREL-DDRNMEVQr 430

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    373 --SLLKGLKSKSINVLIRDIVREQFKifqNDMQETVaqlfktvSSLSEDLESTRQIIQKVNESV----VSIAAQQKFV-- 444
Cdd:pfam15921  431 leALLKAMKSECQGQMERQMAAIQGK---NESLEKV-------SSLTAQLESTKEMLRKVVEELtakkMTLESSERTVsd 500

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    445 ----LVQENR---PTLTDIVELR-----------------NHIVNVRQE---MTLTCEKPIKELEVKQTHLEGALE--QE 495
Cdd:pfam15921  501 ltasLQEKERaieATNAEITKLRsrvdlklqelqhlknegDHLRNVQTEceaLKLQMAEKDKVIEILRQQIENMTQlvGQ 580

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    496 HSRSILYYESLNKTLSklKEVHEQLLSTEQ---VSDQKNAPAAE---SVSNNVTEYMSTLH---------ENIKKQSlmm 560
Cdd:pfam15921  581 HGRTAGAMQVEKAQLE--KEINDRRLELQEfkiLKDKKDAKIREleaRVSDLELEKVKLVNagserlravKDIKQER--- 655

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    561 LQMFEDLHIQESKINNLTVSLEMEKESLRGECEDMlSKCRNDFKFQLKDTEENLHVLNQTL----------AEVLFPMDN 630
Cdd:pfam15921  656 DQLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEEM-ETTTNKLKMQLKSAQSELEQTRNTLksmegsdghaMKVAMGMQK 734

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    631 KMDKMSEQLNDLTYDMEILQPLLEQGASLRQTMTYEQPKEAivirkkiENLTSAVNSLNFIIKELtkrhNLLRNEvqgrd 710
Cdd:pfam15921  735 QITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKNKLS-------QELSTVATEKNKMAGEL----EVLRSQ----- 798

                          490       500       510
                   ....*....|....*....|....*....|...
gi 45269141    711 dalERRINEYALEMEDGLNKTMTIINNAIDFIQ 743
Cdd:pfam15921  799 ---ERRLKEKVANMEVALDKASLQFAECQDIIQ 828
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 339-744 1.95e-06

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 52.33  E-value: 1.95e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    339 QKKIDNISLTVNDVRNTYSSLEGKVSEDKSREFQSLLKGLKS------KSINVLIRDIVREQFKIfqNDMQETVAQLFKT 412
Cdd:TIGR04523  273 QKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQDWNKELKSelknqeKKLEEIQNQISQNNKII--SQLNEQISQLKKE 350

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    413 VSSL-SEDLESTRQIIQKVNESVVSIAAQQKFVlvQENRPTLTDIVELRNHIVNVRQEMTLTCEKpikeLEVKQTHLEgA 491
Cdd:TIGR04523  351 LTNSeSENSEKQRELEEKQNEIEKLKKENQSYK--QEIKNLESQINDLESKIQNQEKLNQQKDEQ----IKKLQQEKE-L 423

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    492 LEQEHSRSILYYESLNKTLSKLKE-------VHEQLLSTEQVSDQKnapaAESVSNNVTEYMSTLhENIKKQSLMMLQMF 564
Cdd:TIGR04523  424 LEKEIERLKETIIKNNSEIKDLTNqdsvkelIIKNLDNTRESLETQ----LKVLSRSINKIKQNL-EQKQKELKSKEKEL 498

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    565 EDLHIQESKINNLTVSLEMEKESLRgECEDMLSKCRNDFKFQLKDTEENLHVLNQTLA-----EVLFPMDNKMDKMSEQL 639
Cdd:TIGR04523  499 KKLNEEKKELEEKVKDLTKKISSLK-EKIEKLESEKKEKESKISDLEDELNKDDFELKkenleKEIDEKNKEIEELKQTQ 577

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    640 NDLTYDMEILQPLLEQgaslrqtmtYEQPKEAIviRKKIENLTSAVNSLNFIIKELTKRHNLLRNEVQGRDDALErRINE 719
Cdd:TIGR04523  578 KSLKKKQEEKQELIDQ---------KEKEKKDL--IKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKN-KLKQ 645

                          410       420
                   ....*....|....*....|....*
gi 45269141    720 YALEMEDGLNKTMTIINNAIDFIQD 744
Cdd:TIGR04523  646 EVKQIKETIKEIRNKWPEIIKKIKE 670
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 340-761 3.12e-05

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 48.67  E-value: 3.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   340 KKIDNISLTVNDVRNTYSSLEGKvsedKSREFQSLLKGLKSKSINV--LIRDIVREQFKIFQNDMQETVAQLFKTVSSLS 417
Cdd:PTZ00440  659 KSKEDLQTLLNTSKNEYEKLEFM----KSDNIDNIIKNLKKELQNLlsLKENIIKKQLNNIEQDISNSLNQYTIKYNDLK 734

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   418 EDLES-----------TRQIIQKVNESVVSIAAQQKFVLVQENrpTLTDIVELRNHIVNVRQEMT---LTCEKPIKELEV 483
Cdd:PTZ00440  735 SSIEEykeeeeklevyKHQIINRKNEFILHLYENDKDLPDGKN--TYEEFLQYKDTILNKENKISndiNILKENKKNNQD 812

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   484 KQTHLEGALEQEHSRSILYYESLNKTLSKLKEVHEQLLSTEQVSDQKNAPAAESVSNNVTEYMSTLHENIKKQslmmlqm 563
Cdd:PTZ00440  813 LLNSYNILIQKLEAHTEKNDEELKQLLQKFPTEDENLNLKELEKEFNENNQIVDNIIKDIENMNKNINIIKTL------- 885

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   564 feDLHIQESKINNLTV-SLEMEKESLRGECEDMLSKCRNDFKFQLKDTEENLHVLNQTLAEVLFPMDN-KMDKMSEQLND 641
Cdd:PTZ00440  886 --NIAINRSNSNKQLVeHLLNNKIDLKNKLEQHMKIINTDNIIQKNEKLNLLNNLNKEKEKIEKQLSDtKINNLKMQIEK 963

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   642 LTYDMEILQPLLEQGASLRQTMTYEQPKEAIVIRKKIENLTSAVNSLN-----FIIKELTKRHNLLRNEVQGRDDALERR 716
Cdd:PTZ00440  964 TLEYYDKSKENINGNDGTHLEKLDKEKDEWEHFKSEIDKLNVNYNILNkkiddLIKKQHDDIIELIDKLIKEKGKEIEEK 1043

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 45269141   717 INEYALEMEDGLNKTMTI-INNAIDFIQDNyALKETLSTIKDNSEI 761
Cdd:PTZ00440 1044 VDQYISLLEKMKTKLSSFhFNIDIKKYKNP-KIKEEIKLLEEKVEA 1088
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 676-873 6.14e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 41.19  E-value: 6.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    676 KKIENLTSAVNSLNFIIKELTKRHNLLRNEVQGRDDALERRINEYALEmEDGLNKTMTIINN---------AIDFIQD-- 744
Cdd:TIGR01612  730 KKNELLDIIVEIKKHIHGEINKDLNKILEDFKNKEKELSNKINDYAKE-KDELNKYKSKISEiknhyndqiNIDNIKDed 808

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    745 ---NY-ALKETLSTIKDNSEIHHKCTSDM----ETILTFIPQFHRLNDSIQTLVNDNQRyNFVLQVAKTLAGIpRDEKLN 816
Cdd:TIGR01612  809 akqNYdKSKEYIKTISIKEDEIFKIINEMkfmkDDFLNKVDKFINFENNCKEKIDSEHE-QFAELTNKIKAEI-SDDKLN 886

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 45269141    817 --QSNFQKMYQMFNETTSQVRKYQQNMSHLEE-----KLLLTTKIS-KNFETRLQDIESKVTQTL 873
Cdd:TIGR01612  887 dyEKKFNDSKSLINEINKSIEEEYQNINTLKKvdeyiKICENTKESiEKFHNKQNILKEILNKNI 951
 
Name Accession Description Interval E-value
C1Q smart00110
Complement component C1q domain; Globular domain found in many collagens and eponymously in ...
 1094-1228 6.27e-45

Complement component C1q domain; Globular domain found in many collagens and eponymously in complement C1q. When part of full length proteins these domains form a 'bouquet' due to the multimerization of heterotrimers. The C1q fold is similar to that of tumour necrosis factor.


Pssm-ID: 128420  Cd Length: 135  Bit Score: 158.62  E-value: 6.27e-45
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    1094 SYRYAPMVAFFASHTygMTIPG---PILFNNLDVNYGASYTPRTGKFRIPYLGVYVFKYTIESFSAHISGFLVVDGIDKL 1170
Cdd:smart00110    1 NYKAQPRSAFSVIRS--NRPPPpgqPIRFDKVLYNQQGHYDPRTGKFTCPVPGVYYFSYHVESKGRNVKVSLMKNGIQVM 78

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    1171 afeSENINSEIHCDRVLTGDALLELNYGQEVWLRL--AKGTIPAKFPPVTTFSGYLLYRT 1228
Cdd:smart00110   79 ---STYDEYQKGLYDVASGGALLQLRQGDQVWLELpdEKNGLYAGEYVDSTFSGFLLFPD 135
C1q pfam00386
C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement ...
 1102-1225 2.57e-35

C1q domain; C1q is a subunit of the C1 enzyme complex that activates the serum complement system.


Pssm-ID: 395310 [Multi-domain]  Cd Length: 126  Bit Score: 130.87  E-value: 2.57e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   1102 AFFASHTYGMTIPG--PILFNNLDVNYGASYTPRTGKFRIPYLGVYVFKYTIES-FSAHISGFLVVDGIDKLAFESENIN 1178
Cdd:pfam00386    1 AFSAGRTTGLTAPNeqPVRFDKVLTNIGGHYDPATGKFTCPVPGVYYFSYHITTvDGKSLYVSLVKNGQEVVSFYDQPQK 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 45269141   1179 SEihcDRVLTGDALLELNYGQEVWLRLA--KGTIPAKFPPVTTFSGYLL 1225
Cdd:pfam00386   81 GS---LDVASGSVVLELQRGDEVWLQLTgyNGLYYDGSDTDSTFSGFLL 126
EMI pfam07546
EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final ...
 208-277 5.28e-15

EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.


Pssm-ID: 462204  Cd Length: 69  Bit Score: 70.91  E-value: 5.28e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 45269141    208 KNWCAYvhtRLSPTVILDNQVTYV----PGGKGPCGWTGgSCPQRsQKISNPVYRMQHKIVTSLDWRCCPGYSG 277
Cdd:pfam07546    1 RNVCAY---KVVSCVVVTGTESYVqpvyKPYLTWCAGHR-RCSTY-RTTYRPAYRQVYKTVTRLEWRCCPGWGG 69
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1045-1077 2.95e-11

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 59.19  E-value: 2.95e-11
                         10        20        30
                 ....*....|....*....|....*....|....
gi 45269141 1045 C-SRHPCQNGGTCINGRTSFTCACRHPFTGDNCT 1077
Cdd:cd00054    5 CaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1045-1075 8.63e-10

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 54.70  E-value: 8.63e-10
                           10        20        30
                   ....*....|....*....|....*....|.
gi 45269141   1045 CSRHPCQNGGTCINGRTSFTCACRHPFTGDN 1075
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1045-1077 5.68e-09

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 52.48  E-value: 5.68e-09
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 45269141 1045 CSR-HPCQNGGTCINGRTSFTCACRHPFTGD-NCT 1077
Cdd:cd00053    2 CAAsNPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1045-1077 1.73e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 51.48  E-value: 1.73e-08
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 45269141    1045 C-SRHPCQNGGTCINGRTSFTCACRHPFT-GDNCT 1077
Cdd:smart00179    5 CaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 296-743 1.24e-07

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 56.28  E-value: 1.24e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    296 AESHTAVGRGVAEQQQQQGCGDPEVMQKMTDQVNYQAMKLTLlqKKIDNISLTVNDVRN--TYSSLEGKVsEDKSREFQ- 372
Cdd:pfam15921  354 ANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSL--EKEQNKRLWDRDTGNsiTIDHLRREL-DDRNMEVQr 430

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    373 --SLLKGLKSKSINVLIRDIVREQFKifqNDMQETVaqlfktvSSLSEDLESTRQIIQKVNESV----VSIAAQQKFV-- 444
Cdd:pfam15921  431 leALLKAMKSECQGQMERQMAAIQGK---NESLEKV-------SSLTAQLESTKEMLRKVVEELtakkMTLESSERTVsd 500

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    445 ----LVQENR---PTLTDIVELR-----------------NHIVNVRQE---MTLTCEKPIKELEVKQTHLEGALE--QE 495
Cdd:pfam15921  501 ltasLQEKERaieATNAEITKLRsrvdlklqelqhlknegDHLRNVQTEceaLKLQMAEKDKVIEILRQQIENMTQlvGQ 580

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    496 HSRSILYYESLNKTLSklKEVHEQLLSTEQ---VSDQKNAPAAE---SVSNNVTEYMSTLH---------ENIKKQSlmm 560
Cdd:pfam15921  581 HGRTAGAMQVEKAQLE--KEINDRRLELQEfkiLKDKKDAKIREleaRVSDLELEKVKLVNagserlravKDIKQER--- 655

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    561 LQMFEDLHIQESKINNLTVSLEMEKESLRGECEDMlSKCRNDFKFQLKDTEENLHVLNQTL----------AEVLFPMDN 630
Cdd:pfam15921  656 DQLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEEM-ETTTNKLKMQLKSAQSELEQTRNTLksmegsdghaMKVAMGMQK 734

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    631 KMDKMSEQLNDLTYDMEILQPLLEQGASLRQTMTYEQPKEAivirkkiENLTSAVNSLNFIIKELtkrhNLLRNEvqgrd 710
Cdd:pfam15921  735 QITAKRGQIDALQSKIQFLEEAMTNANKEKHFLKEEKNKLS-------QELSTVATEKNKMAGEL----EVLRSQ----- 798

                          490       500       510
                   ....*....|....*....|....*....|...
gi 45269141    711 dalERRINEYALEMEDGLNKTMTIINNAIDFIQ 743
Cdd:pfam15921  799 ---ERRLKEKVANMEVALDKASLQFAECQDIIQ 828
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 416-897 4.52e-07

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 54.34  E-value: 4.52e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    416 LSEDLESTRQIIQKVNESVVSIAAQQKFVLVQ----ENR-PTLTDIVELRNHIVNVRQEMTLTCEKPIKELEVKQTHLEG 490
Cdd:pfam05483  217 LKEDHEKIQHLEEEYKKEINDKEKQVSLLLIQitekENKmKDLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTK 296

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    491 ALEQehsrsilYYESLNKTLSKLKEVHEQL-LSTE---QVSDQKNAPAAESVSNNVTEYMSTLHENIKKQSLMMLQMFED 566
Cdd:pfam05483  297 ELED-------IKMSLQRSMSTQKALEEDLqIATKticQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSLEELLRTEQ 369

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    567 LHIQESKINNLTVSLEMEKESlrGECEDMlSKCRNDFKFQLKDteenlhvLNQTLAE--VLFPMDNKMDKMSEQLNDLTY 644
Cdd:pfam05483  370 QRLEKNEDQLKIITMELQKKS--SELEEM-TKFKNNKEVELEE-------LKKILAEdeKLLDEKKQFEKIAEELKGKEQ 439

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    645 DMEILQPLLEQ-----GASLRQTMTYEQ--PKEAIVIRKKIEN-------LTSAVNSLNFIIKELTKRHNLLRNEVQGRD 710
Cdd:pfam05483  440 ELIFLLQAREKeihdlEIQLTAIKTSEEhyLKEVEDLKTELEKeklknieLTAHCDKLLLENKELTQEASDMTLELKKHQ 519

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    711 DALE--RRINEYALEMEDGLNKTMTIINNAIDFIQDNYalketlstIKDNSEIhhKCTSDMETILTFIPQFHRLNDSIQT 788
Cdd:pfam05483  520 EDIIncKKQEERMLKQIENLEEKEMNLRDELESVREEF--------IQKGDEV--KCKLDKSEENARSIEYEVLKKEKQM 589

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    789 LVNDNQRYNFVLQVAKTLAGIprdEKLNQSNfQKMYQMFNETTSQVRKYQQNMSHLEEKLLLTTK----ISKNFETRLQD 864
Cdd:pfam05483  590 KILENKCNNLKKQIENKNKNI---EELHQEN-KALKKKGSAENKQLNAYEIKVNKLELELASAKQkfeeIIDNYQKEIED 665

                          490       500       510
                   ....*....|....*....|....*....|...
gi 45269141    865 ieSKVTQTLIpyYISVKKGSVVTnerDQALQLQ 897
Cdd:pfam05483  666 --KKISEEKL--LEEVEKAKAIA---DEAVKLQ 691
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 339-744 1.95e-06

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 52.33  E-value: 1.95e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    339 QKKIDNISLTVNDVRNTYSSLEGKVSEDKSREFQSLLKGLKS------KSINVLIRDIVREQFKIfqNDMQETVAQLFKT 412
Cdd:TIGR04523  273 QKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQDWNKELKSelknqeKKLEEIQNQISQNNKII--SQLNEQISQLKKE 350

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    413 VSSL-SEDLESTRQIIQKVNESVVSIAAQQKFVlvQENRPTLTDIVELRNHIVNVRQEMTLTCEKpikeLEVKQTHLEgA 491
Cdd:TIGR04523  351 LTNSeSENSEKQRELEEKQNEIEKLKKENQSYK--QEIKNLESQINDLESKIQNQEKLNQQKDEQ----IKKLQQEKE-L 423

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    492 LEQEHSRSILYYESLNKTLSKLKE-------VHEQLLSTEQVSDQKnapaAESVSNNVTEYMSTLhENIKKQSLMMLQMF 564
Cdd:TIGR04523  424 LEKEIERLKETIIKNNSEIKDLTNqdsvkelIIKNLDNTRESLETQ----LKVLSRSINKIKQNL-EQKQKELKSKEKEL 498

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    565 EDLHIQESKINNLTVSLEMEKESLRgECEDMLSKCRNDFKFQLKDTEENLHVLNQTLA-----EVLFPMDNKMDKMSEQL 639
Cdd:TIGR04523  499 KKLNEEKKELEEKVKDLTKKISSLK-EKIEKLESEKKEKESKISDLEDELNKDDFELKkenleKEIDEKNKEIEELKQTQ 577

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    640 NDLTYDMEILQPLLEQgaslrqtmtYEQPKEAIviRKKIENLTSAVNSLNFIIKELTKRHNLLRNEVQGRDDALErRINE 719
Cdd:TIGR04523  578 KSLKKKQEEKQELIDQ---------KEKEKKDL--IKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKN-KLKQ 645

                          410       420
                   ....*....|....*....|....*
gi 45269141    720 YALEMEDGLNKTMTIINNAIDFIQD 744
Cdd:TIGR04523  646 EVKQIKETIKEIRNKWPEIIKKIKE 670
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 338-821 4.26e-06

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 51.26  E-value: 4.26e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    338 LQKKIDNISLTVNDVRNTYSSLEG----------KVSEDKSREFQSLLKGLKSKSINVL--------IRDIVR-EQFKIF 398
Cdd:pfam05483  294 LTKELEDIKMSLQRSMSTQKALEEdlqiatkticQLTEEKEAQMEELNKAKAAHSFVVTefeattcsLEELLRtEQQRLE 373

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    399 QNDMQETV--AQLFKTVSSLSEDLESTRQIIQKVNESVVSIAAQQKfvLVQENRptltDIVELRNHIVNVRQEMTL---T 473
Cdd:pfam05483  374 KNEDQLKIitMELQKKSSELEEMTKFKNNKEVELEELKKILAEDEK--LLDEKK----QFEKIAEELKGKEQELIFllqA 447

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    474 CEKPIKELEVKQTHLEGAlEQEHSRSIlyyESLNKTLSKLKEVHEQLLSTEQVSDQKNAPAAESVSNNVTEYMSTLHE-- 551
Cdd:pfam05483  448 REKEIHDLEIQLTAIKTS-EEHYLKEV---EDLKTELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDii 523

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    552 NIKKQSLMMLQMFEDLHIQESKINNltvslemEKESLRGEcedmLSKCRNDFKFQLKDTEENlhvlNQTLAEVLFPMDNK 631
Cdd:pfam05483  524 NCKKQEERMLKQIENLEEKEMNLRD-------ELESVREE----FIQKGDEVKCKLDKSEEN----ARSIEYEVLKKEKQ 588

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    632 MDKMSEQLNDLtydmeilqplleqgaslrqtmtyeqpkeaiviRKKIENLTSAVNSLNFIIKELTKRHNLLRNEVqgrdD 711
Cdd:pfam05483  589 MKILENKCNNL--------------------------------KKQIENKNKNIEELHQENKALKKKGSAENKQL----N 632

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    712 ALERRINEYALEMEDGLNKTMTIINNAIDFIQDNYALKETL------------STIKDNSEIHHKCTsdmetiltfipqf 779
Cdd:pfam05483  633 AYEIKVNKLELELASAKQKFEEIIDNYQKEIEDKKISEEKLleevekakaiadEAVKLQKEIDKRCQ------------- 699

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|..
gi 45269141    780 HRLNDSIQTLVNDNQRYNFVLQVAKTLAGIPRDEKLNQSNFQ 821
Cdd:pfam05483  700 HKIAEMVALMEKHKHQYDKIIEERDSELGLYKNKEQEQSSAK 741
EGF smart00181
Epidermal growth factor-like domain;
1045-1076 7.18e-06

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 44.04  E-value: 7.18e-06
                            10        20        30
                    ....*....|....*....|....*....|....
gi 45269141    1045 CS-RHPCQNGgTCINGRTSFTCACRHPFTGD-NC 1076
Cdd:smart00181    2 CAsGGPCSNG-TCINTPGSYTCSCPPGYTGDkRC 34
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 340-761 3.12e-05

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 48.67  E-value: 3.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   340 KKIDNISLTVNDVRNTYSSLEGKvsedKSREFQSLLKGLKSKSINV--LIRDIVREQFKIFQNDMQETVAQLFKTVSSLS 417
Cdd:PTZ00440  659 KSKEDLQTLLNTSKNEYEKLEFM----KSDNIDNIIKNLKKELQNLlsLKENIIKKQLNNIEQDISNSLNQYTIKYNDLK 734

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   418 EDLES-----------TRQIIQKVNESVVSIAAQQKFVLVQENrpTLTDIVELRNHIVNVRQEMT---LTCEKPIKELEV 483
Cdd:PTZ00440  735 SSIEEykeeeeklevyKHQIINRKNEFILHLYENDKDLPDGKN--TYEEFLQYKDTILNKENKISndiNILKENKKNNQD 812

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   484 KQTHLEGALEQEHSRSILYYESLNKTLSKLKEVHEQLLSTEQVSDQKNAPAAESVSNNVTEYMSTLHENIKKQslmmlqm 563
Cdd:PTZ00440  813 LLNSYNILIQKLEAHTEKNDEELKQLLQKFPTEDENLNLKELEKEFNENNQIVDNIIKDIENMNKNINIIKTL------- 885

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   564 feDLHIQESKINNLTV-SLEMEKESLRGECEDMLSKCRNDFKFQLKDTEENLHVLNQTLAEVLFPMDN-KMDKMSEQLND 641
Cdd:PTZ00440  886 --NIAINRSNSNKQLVeHLLNNKIDLKNKLEQHMKIINTDNIIQKNEKLNLLNNLNKEKEKIEKQLSDtKINNLKMQIEK 963

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   642 LTYDMEILQPLLEQGASLRQTMTYEQPKEAIVIRKKIENLTSAVNSLN-----FIIKELTKRHNLLRNEVQGRDDALERR 716
Cdd:PTZ00440  964 TLEYYDKSKENINGNDGTHLEKLDKEKDEWEHFKSEIDKLNVNYNILNkkiddLIKKQHDDIIELIDKLIKEKGKEIEEK 1043

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 45269141   717 INEYALEMEDGLNKTMTI-INNAIDFIQDNyALKETLSTIKDNSEI 761
Cdd:PTZ00440 1044 VDQYISLLEKMKTKLSSFhFNIDIKKYKNP-KIKEEIKLLEEKVEA 1088
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
458-736 1.65e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 46.21  E-value: 1.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   458 ELRNHIVNVRQEMTLTcEKPIKELEVKQTHLEGALEQEHSRsilyYESLNKTLSKLKEVHEQLLSTEqvsdqKNAPAAES 537
Cdd:PRK03918  190 NIEELIKEKEKELEEV-LREINEISSELPELREELEKLEKE----VKELEELKEEIEELEKELESLE-----GSKRKLEE 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   538 VSNNVTEYMSTLHENIKKQslmmlqmfedlhiqESKINNLTVSLEMEKESLRgecedmLSKCRNDFKFQLKDTEENLHVL 617
Cdd:PRK03918  260 KIRELEERIEELKKEIEEL--------------EEKVKELKELKEKAEEYIK------LSEFYEEYLDELREIEKRLSRL 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   618 NQTLAEV------LFPMDNKMDKMSEQLNDLTYDMEILQP----------LLEQGASLRQTMTYEQPKEAIV-------- 673
Cdd:PRK03918  320 EEEINGIeerikeLEEKEERLEELKKKLKELEKRLEELEErhelyeeakaKKEELERLKKRLTGLTPEKLEKeleeleka 399

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 45269141   674 ---IRKKIENLTSAVNSLNFIIKELTKRHNLLRNE-----VQGR---DDALERRINEYALEMEDGLNKTMTIIN 736
Cdd:PRK03918  400 keeIEEEISKITARIGELKKEIKELKKAIEELKKAkgkcpVCGReltEEHRKELLEEYTAELKRIEKELKEIEE 473
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 1050-1067 3.30e-04

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 38.85  E-value: 3.30e-04
                           10
                   ....*....|....*...
gi 45269141   1050 CQNGGTCINGRTSFTCAC 1067
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQC 18
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
 387-650 9.79e-04

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 43.30  E-value: 9.79e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    387 IRDIVREQFKIFQNDMQETVAQLFKTVSSLSE-----DLESTRQIIQKVNESV--------VSIAAQQKfvlVQENRPTL 453
Cdd:pfam06160  220 YREMEEEGYALEHLNVDKEIQQLEEQLEENLAllenlELDEAEEALEEIEERIdqlydlleKEVDAKKY---VEKNLPEI 296

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    454 TDIVElrnHIVNVRQEMTLtcekpikELE-VKQTHLEGALEQEHSRSilyyesLNKTLSKLKEVHEQLlstEQVSDQKNA 532
Cdd:pfam06160  297 EDYLE---HAEEQNKELKE-------ELErVQQSYTLNENELERVRG------LEKQLEELEKRYDEI---VERLEEKEV 357

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    533 PAAEsVSNNVTEYMSTLhENIKKQSLMMLQMFEDLHIQESKINN---------LTVSLEMEKESLRGecedmLSkcrNDF 603
Cdd:pfam06160  358 AYSE-LQEELEEILEQL-EEIEEEQEEFKESLQSLRKDELEAREkldefklelREIKRLVEKSNLPG-----LP---ESY 427

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 45269141    604 KFQLKDTEENLHVLNQTLAEVlfPMDnkMDKMSEQLNDLTYDMEILQ 650
Cdd:pfam06160  428 LDYFFDVSDEIEDLADELNEV--PLN--MDEVNRLLDEAQDDVDTLY 470
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1045-1076 1.04e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.58  E-value: 1.04e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 45269141   1045 CSR--HPCQNGGTCINGRTSFTCACRHPFTGD--NC 1076
Cdd:pfam12947    1 CSDnnGGCHPNATCTNTGGSFTCTCNDGYTGDgvTC 36
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 334-1027 1.57e-03

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 42.90  E-value: 1.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   334 KLTLLQKKIDNISLTVNDVRNTYSSLE-GKVSEDKSREFQSLLKGLKSKSINVL-IRDIVREQFKIFQNDMQEtVAQLFK 411
Cdd:PTZ00440  451 KINELKKSINQLKTLISIMKSFYDLIIsEKDSMDSKEKKESSDSNYQEKVDELLqIINSIKEKNNIVNNNFKN-IEDYYI 529

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   412 TVSSLSEDLESTRQIIQKVNESVVSIAAQQKfvlvqENRPTLTDIvelRNHIVNVRQEMtltceKPIKELEvkqthlega 491
Cdd:PTZ00440  530 TIEGLKNEIEGLIELIKYYLQSIETLIKDEK-----LKRSMKNDI---KNKIKYIEENV-----DHIKDII--------- 587

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   492 leqehsrsilyyeSLNKTLSKLKEVHEQLLSTEQVSDQKNAPAAESVSNNVTEYMSTLHENIKKQSLMMLQMFEDLH--- 568
Cdd:PTZ00440  588 -------------SLNDEIDNIIQQIEELINEALFNKEKFINEKNDLQEKVKYILNKFYKGDLQELLDELSHFLDDHkyl 654

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   569 IQESKINNLTVSLEMEKESLRGECEDMLSKCRNDFKFQLKDTEENLHVLNQTLAEVLF-----PMDNKMDKMSEQLNDLT 643
Cdd:PTZ00440  655 YHEAKSKEDLQTLLNTSKNEYEKLEFMKSDNIDNIIKNLKKELQNLLSLKENIIKKQLnnieqDISNSLNQYTIKYNDLK 734

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   644 YDMEilqplleqgaslrqtmTYEQPKEAIVIRKK--IENLTSAVNSLNFIIKELTKRHNLLRNEVQGRDDALERrineya 721
Cdd:PTZ00440  735 SSIE----------------EYKEEEEKLEVYKHqiINRKNEFILHLYENDKDLPDGKNTYEEFLQYKDTILNK------ 792

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   722 lemEDGLNKTMTIINNAIDFIQDNYALKETLS-TIKDNSEIHhkcTSDMETILTFIP-------------QFHRLNDSIQ 787
Cdd:PTZ00440  793 ---ENKISNDINILKENKKNNQDLLNSYNILIqKLEAHTEKN---DEELKQLLQKFPtedenlnlkelekEFNENNQIVD 866

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   788 TLVNDNQRYNFVLQVAKTLA-GIPRDEKLNQS------NFQKMYQMFNETTSQVRKYqqNMSHLEEKLLLTTKISK---N 857
Cdd:PTZ00440  867 NIIKDIENMNKNINIIKTLNiAINRSNSNKQLvehllnNKIDLKNKLEQHMKIINTD--NIIQKNEKLNLLNNLNKekeK 944

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   858 FETRLQDI-----ESKVTQTLIPYYISvkKGSVVTNERDQALQLQVLNSRFKALEAKSIHLSINFFSLNKTLHEVLTMCH 932
Cdd:PTZ00440  945 IEKQLSDTkinnlKMQIEKTLEYYDKS--KENINGNDGTHLEKLDKEKDEWEHFKSEIDKLNVNYNILNKKIDDLIKKQH 1022

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   933 NastsvselnatipKWIKHSLPDIQLLQKGLTEFVEPIIQI--KTQAALSNLTCCIDRSL---PGSLANVVKSQKQVKSL 1007
Cdd:PTZ00440 1023 D-------------DIIELIDKLIKEKGKEIEEKVDQYISLleKMKTKLSSFHFNIDIKKyknPKIKEEIKLLEEKVEAL 1089

                         730       740
                  ....*....|....*....|
gi 45269141  1008 PKKINALKKPTVNLTTVLIG 1027
Cdd:PTZ00440 1090 LKKIDENKNKLIEIKNKSHE 1109
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
340-719 3.84e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 41.59  E-value: 3.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   340 KKIDNISLTVNDVRNTYSSLEGKVS--EDKSREFQSLLKGLKSKsINVLiRDIVREQFKI------------FQNDMQET 405
Cdd:PRK03918  231 KELEELKEEIEELEKELESLEGSKRklEEKIRELEERIEELKKE-IEEL-EEKVKELKELkekaeeyiklseFYEEYLDE 308

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   406 VAQLFKTVSSLSEDLESTRQIIQKVNESVVSIAA--------QQKFVLVQENRPTLTDIVELRNHIVNVRQEMT-LTCEK 476
Cdd:PRK03918  309 LREIEKRLSRLEEEINGIEERIKELEEKEERLEElkkklkelEKRLEELEERHELYEEAKAKKEELERLKKRLTgLTPEK 388

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   477 PIKELE-VKQTHLEgaLEQEHSRSILYYESLNKTLSKLKEVHEQLLSTEQVSDQKNAPAAESVSNNVTEYMSTLHENIKK 555
Cdd:PRK03918  389 LEKELEeLEKAKEE--IEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELTEEHRKELLEEYTAELKRIEK 466

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   556 QslmmLQMFEDlhiQESKINNLTVSLEMEkesLRGECEdmLSKCRNDFKfQLKDTEENLHVLNqtlAEVLFPMDNKMDKM 635
Cdd:PRK03918  467 E----LKEIEE---KERKLRKELRELEKV---LKKESE--LIKLKELAE-QLKELEEKLKKYN---LEELEKKAEEYEKL 530

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   636 SEQLNDLTYDMEILQPLLEQGASLRqtmtyeqpKEAIVIRKKIENLTsavnslnfiiKELTKRHNLLRNEVQGRDDALER 715
Cdd:PRK03918  531 KEKLIKLKGEIKSLKKELEKLEELK--------KKLAELEKKLDELE----------EELAELLKELEELGFESVEELEE 592


                  ....
gi 45269141   716 RINE 719
Cdd:PRK03918  593 RLKE 596
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 482-866 5.26e-03

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 40.97  E-value: 5.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   482 EVKQTHLEGALEQEhsrsilyYESLNK-----TLSKLKEVHEQLLSTEQVSDQKNAPAAESVSNNVTEYMSTLHENIKKq 556
Cdd:PRK04778   52 KVKKLNLTGQSEEK-------FEEWRQkwdeiVTNSLPDIEEQLFEAEELNDKFRFRKAKHEINEIESLLDLIEEDIEQ- 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   557 slmMLQMFEDLHIQESKINNLTVSLEMEKESLRgecEDMLSkcrNDFKF---------QLKDTEENLH---VLNQ----- 619
Cdd:PRK04778  124 ---ILEELQELLESEEKNREEVEQLKDLYRELR---KSLLA---NRFSFgpaldelekQLENLEEEFSqfvELTEsgdyv 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   620 TLAEVLfpmdnkmDKMSEQLNDLTYDMEILQPLL--------EQGASLRQtmTYEQ-------------PKEAIVIRKKI 678
Cdd:PRK04778  195 EAREIL-------DQLEEELAALEQIMEEIPELLkelqtelpDQLQELKA--GYRElveegyhldhldiEKEIQDLKEQI 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   679 ENLTSAVNSLNF-----IIKELTKR----HNLLRNEVQGRDDALER--RINEYALEMEDGLNKTMTiinnAIDFIQDNY- 746
Cdd:PRK04778  266 DENLALLEELDLdeaeeKNEEIQERidqlYDILEREVKARKYVEKNsdTLPDFLEHAKEQNKELKE----EIDRVKQSYt 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   747 ----------ALKETLSTIKDNSEIHHKCTSD-----------METILTFIPQFH----RLNDSIQTLVNDNQRYN-FVL 800
Cdd:PRK04778  342 lneselesvrQLEKQLESLEKQYDEITERIAEqeiayselqeeLEEILKQLEEIEkeqeKLSEMLQGLRKDELEAReKLE 421

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141   801 QVAKTLAGIPRdeKLNQSNF----QKMYQMFNETTSQVrkyQQNMSHLEEKLLLTTKISKNFETRLQDIE 866
Cdd:PRK04778  422 RYRNKLHEIKR--YLEKSNLpglpEDYLEMFFEVSDEI---EALAEELEEKPINMEAVNRLLEEATEDVE 486
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 676-873 6.14e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 41.19  E-value: 6.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    676 KKIENLTSAVNSLNFIIKELTKRHNLLRNEVQGRDDALERRINEYALEmEDGLNKTMTIINN---------AIDFIQD-- 744
Cdd:TIGR01612  730 KKNELLDIIVEIKKHIHGEINKDLNKILEDFKNKEKELSNKINDYAKE-KDELNKYKSKISEiknhyndqiNIDNIKDed 808

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    745 ---NY-ALKETLSTIKDNSEIHHKCTSDM----ETILTFIPQFHRLNDSIQTLVNDNQRyNFVLQVAKTLAGIpRDEKLN 816
Cdd:TIGR01612  809 akqNYdKSKEYIKTISIKEDEIFKIINEMkfmkDDFLNKVDKFINFENNCKEKIDSEHE-QFAELTNKIKAEI-SDDKLN 886

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 45269141    817 --QSNFQKMYQMFNETTSQVRKYQQNMSHLEE-----KLLLTTKIS-KNFETRLQDIESKVTQTL 873
Cdd:TIGR01612  887 dyEKKFNDSKSLINEINKSIEEEYQNINTLKKvdeyiKICENTKESiEKFHNKQNILKEILNKNI 951
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 455-761 6.65e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.82  E-value: 6.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    455 DIVELRNHIVNVRQEMTlTCEKPIKELEVKQTHLEGALEQEHSRsilyyeslnktlskLKEVHEQLLSTEQvsdqknapa 534
Cdd:TIGR02169  696 ELRRIENRLDELSQELS-DASRKIGEIEKEIEQLEQEEEKLKER--------------LEELEEDLSSLEQ--------- 751

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    535 aesvsnNVTEYMSTLHENIKKQSlmmlQMFEDLHIQESKINNLTVSLEMEK-ESLRGECEDMlskcrndfKFQLKDTEEN 613
Cdd:TIGR02169  752 ------EIENVKSELKELEARIE----ELEEDLHKLEEALNDLEARLSHSRiPEIQAELSKL--------EEEVSRIEAR 813

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    614 LHVLNQtlaevlfpmdnkmdkmseQLNDLTYDMEILQPLLeQGASLRQTMTYEQPKEaivIRKKIENLTSAVNSLNFIIK 693
Cdd:TIGR02169  814 LREIEQ------------------KLNRLTLEKEYLEKEI-QELQEQRIDLKEQIKS---IEKEIENLNGKKEELEEELE 871

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45269141    694 ELTKRHNLLRNEVQGRDDALERRINEYAlEMEDGLNKTMTIINNAIDFIQDnyaLKETLSTIKDN-SEI 761
Cdd:TIGR02169  872 ELEAALRDLESRLGDLKKERDELEAQLR-ELERKIEELEAQIEKKRKRLSE---LKAKLEALEEElSEI 936
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 282-679 8.36e-03

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 40.58  E-value: 8.36e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    282 LRAQEQQSLIHTNQAEshtavgrgVAEQQQQQGCGDPEVmQKMTDQVNYQAMKLTLLQKKIDNISLTVNDVrntysslEG 361
Cdd:pfam10174  352 LRLEEKESFLNKKTKQ--------LQDLTEEKSTLAGEI-RDLKDMLDVKERKINVLQKKIENLQEQLRDK-------DK 415

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    362 KVSEDKSRefqslLKGLKSKSIN-----VLIRDIVREQFKIFQNdMQEtvaQLFKTVSSLSEDLESTRQIIQKVNESVvs 436
Cdd:pfam10174  416 QLAGLKER-----VKSLQTDSSNtdtalTTLEEALSEKERIIER-LKE---QREREDRERLEELESLKKENKDLKEKV-- 484

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    437 iAAQQKFVLVQEnrptlTDIVELRNHIVNVRQEMTLtcekpiKELEVKQthLEGALEQEhsrsilyYESLNKTLSKLKEV 516
Cdd:pfam10174  485 -SALQPELTEKE-----SSLIDLKEHASSLASSGLK------KDSKLKS--LEIAVEQK-------KEECSKLENQLKKA 543

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    517 HEQllsteQVSDQKNAPAAESVSNNVTEYMSTLHENIKKQS----LM--MLQMFEDLHIQESKINnltvslEMEKESLRg 590
Cdd:pfam10174  544 HNA-----EEAVRTNPEINDRIRLLEQEVARYKEESGKAQAeverLLgiLREVENEKNDKDKKIA------ELESLTLR- 611

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    591 ECEDMLSKCRNDFKFQLKDTEENLhvlnQTLAEVLFPMDNKMDKMSE-QLNDLTYDME-ILQPLLEQGASLRQTMTYEQP 668
Cdd:pfam10174  612 QMKEQNKKVANIKHGQQEMKKKGA----QLLEEARRREDNLADNSQQlQLEELMGALEkTRQELDATKARLSSTQQSLAE 687

                          410
                   ....*....|.
gi 45269141    669 KEAIVIRKKIE 679
Cdd:pfam10174  688 KDGHLTNLRAE 698
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 321-947 8.46e-03

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 40.81  E-value: 8.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    321 MQKMTDQVNYQAMK-LTLLQKKIDNISLTVNDVRNtysslegkvSEDKSREFqSLLKGLKSKSINvlirdIVREQFKIFQ 399
Cdd:TIGR01612 1826 FKKKLDHVNDKFTKeYSKINEGFDDISKSIENVKN---------STDENLLF-DILNKTKDAYAG-----IIGKKYYSYK 1890

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    400 NDMQETVAQLFKTVSSLSEDLESTRQI--IQKVNESVVSIAAQQ-----KFVLVQENRP-TLTDIVELRNHIVNVRQEMT 471
Cdd:TIGR01612 1891 DEAEKIFINISKLANSINIQIQNNSGIdlFDNINIAILSSLDSEkedtlKFIPSPEKEPeIYTKIRDSYDTLLDIFKKSQ 1970

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    472 LTCEKPIKELEVKQTHlegaleQEHSRSILYYESLNKTLSKLKEVHEQLLSTEQV----SDQKNAPAAESvSNNVTEYMS 547
Cdd:TIGR01612 1971 DLHKKEQDTLNIIFEN------QQLYEKIQASNELKDTLSDLKYKKEKILNDVKLllhkFDELNKLSCDS-QNYDTILEL 2043

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    548 TLHENIK------KQSLMMLQMFEDLHIQESKINNLTVSLEmekeslrgecedmlsKCRNDFKFQLKDTEENLHVLNQTL 621
Cdd:TIGR01612 2044 SKQDKIKekidnyEKEKEKFGIDFDVKAMEEKFDNDIKDIE---------------KFENNYKHSEKDNHDFSEEKDNII 2108

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    622 AEvlfpmDNKMDKMSEQLNdlTYDMEILQPLLEQGASLRQTMtyEQPKEAIVIRKK--IENLTSAVNSLNFIIKELTKrh 699
Cdd:TIGR01612 2109 QS-----KKKLKELTEAFN--TEIKIIEDKIIEKNDLIDKLI--EMRKECLLFSYAtlVETLKSKVINHSEFITSAAK-- 2177

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    700 nllrnevqgrddalerrineYALEMEDGLNKTMTIINNAIDFIQDNYALKET--------LSTIKDNSEIHHKCTSDMET 771
Cdd:TIGR01612 2178 --------------------FSKDFFEFIEDISDSLNDDIDALQIKYNLNQTkkhmisilADATKDHNNLIEKEKEATKI 2237

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    772 I--LTFIPQFHRLNDSIQTLVNDN-QRYNFVLQVAKTLAGIprdeklnqsnfQKMYQmfnettsQVRKYQ-QNMSHLEEK 847
Cdd:TIGR01612 2238 InnLTELFTIDFNNADADILHNNKiQIIYFNSELHKSIESI-----------KKLYK-------KINAFKlLNISHINEK 2299

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45269141    848 LlltTKISKNFETRLQDIESKVTQTL-----IPYYISVKKGSVVtnerdQALQlQVLNSRFKALeaKSIHLSInfFSLNK 922
Cdd:TIGR01612 2300 Y---FDISKEFDNIIQLQKHKLTENLndlkeIDQYISDKKNIFL-----HALN-ENTNFNFNAL--KEIYDDI--INREN 2366

                          650       660
                   ....*....|....*....|....*
gi 45269141    923 TLHEVLTMCHNASTSVSELNATIPK 947
Cdd:TIGR01612 2367 KADEIENINNKENENIMQYIDTITK 2391
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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