NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|6678654|ref|NP_032505|]
View 

lymphocyte activation gene 3 protein precursor [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 261-344 3.57e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 50.97  E-value: 3.57e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678654     261 PLTVYAAEGSRVELPCHLPpgvGTPSLLIaKW-----TPPGGGPELPVAGKSGNFTLHLEAVGLAQAGTYTCSIHLQGQQ 335
Cdd:smart00410   1 PPSVTVKEGESVTLSCEAS---GSPPPEV-TWykqggKLLAESGRFSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGS 76


                   ....*....
gi 6678654     336 LNATVTLAV 344
Cdd:smart00410  77 ASSGTTLTV 85
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 168-246 4.98e-06

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


:

Pssm-ID: 395002  Cd Length: 86  Bit Score: 44.88  E-value: 4.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678654    168 IASPSGVLKLSDWVLLNCSFSRPDRPVSVHWFQGQNRVP-----VYNSPRHFLAEtfLLLPQVSPLDSGTWGCVLTYRDG 242
Cdd:pfam00047   1 SAPPTVTVLEGDSATLTCSASTGSPGPDVTWSKEGGTLIeslkvKHDNGRTTQSS--LLISNVTKEDAGTYTCVVNNPGG 78


                  ....
gi 6678654    243 FNVS 246
Cdd:pfam00047  79 SATL 82
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 261-344 3.57e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 50.97  E-value: 3.57e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678654     261 PLTVYAAEGSRVELPCHLPpgvGTPSLLIaKW-----TPPGGGPELPVAGKSGNFTLHLEAVGLAQAGTYTCSIHLQGQQ 335
Cdd:smart00410   1 PPSVTVKEGESVTLSCEAS---GSPPPEV-TWykqggKLLAESGRFSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGS 76


                   ....*....
gi 6678654     336 LNATVTLAV 344
Cdd:smart00410  77 ASSGTTLTV 85
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 261-344 2.86e-07

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 48.99  E-value: 2.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678654    261 PLTVYAAEGSRVELPCHLPPGVGTPSLLIaKWT--PPGGGPELPVAGKS--------------------GNFTLHLEAVG 318
Cdd:pfam07686   3 PREVTVALGGSVTLPCTYSSSMSEASTSV-YWYrqPPGKGPTFLIAYYSngseegvkkgrfsgrgdpsnGDGSLTIQNLT 81

                          90       100
                  ....*....|....*....|....*..
gi 6678654    319 LAQAGTYTCSIHLQG-QQLNATVTLAV 344
Cdd:pfam07686  82 LSDSGTYTCAVIPSGeGVFGKGTRLTV 108
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 168-246 4.98e-06

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 44.88  E-value: 4.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678654    168 IASPSGVLKLSDWVLLNCSFSRPDRPVSVHWFQGQNRVP-----VYNSPRHFLAEtfLLLPQVSPLDSGTWGCVLTYRDG 242
Cdd:pfam00047   1 SAPPTVTVLEGDSATLTCSASTGSPGPDVTWSKEGGTLIeslkvKHDNGRTTQSS--LLISNVTKEDAGTYTCVVNNPGG 78


                  ....
gi 6678654    243 FNVS 246
Cdd:pfam00047  79 SATL 82
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 181-248 1.42e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 37.31  E-value: 1.42e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678654  181 VLLNCSFSRPDRPvSVHWFQGQNRVP--VYNSPRHFLAETFLLLPQVSPLDSGTWGCVLTYRDGFNVSIT 248
Cdd:cd00096   1 VTLTCSASGNPPP-TITWYKNGKPLPpsSRDSRRSELGNGTLTISNVTLEDSGTYTCVASNSAGGSASAS 69
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 258-341 5.92e-03

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 36.22  E-value: 5.92e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678654  258 PVAPLTVYAAEGSRVELPCHLPPGVGTPSLLIAKW-------------TPPGGGPELPVAGKSGNFTLHLEAVGLAQAGT 324
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWgsegcqtlvssegVVPGGRISLTDDPDNGVFTVTLNQLRKEDAGW 80

                        90       100
                ....*....|....*....|
gi 6678654  325 YTCSI---HLQGQQLNATVT 341
Cdd:cd05716  81 YWCGVgddGDRGLTVQVKLV 100
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 261-344 3.57e-08

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 50.97  E-value: 3.57e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678654     261 PLTVYAAEGSRVELPCHLPpgvGTPSLLIaKW-----TPPGGGPELPVAGKSGNFTLHLEAVGLAQAGTYTCSIHLQGQQ 335
Cdd:smart00410   1 PPSVTVKEGESVTLSCEAS---GSPPPEV-TWykqggKLLAESGRFSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGS 76


                   ....*....
gi 6678654     336 LNATVTLAV 344
Cdd:smart00410  77 ASSGTTLTV 85
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 261-344 2.86e-07

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 48.99  E-value: 2.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678654    261 PLTVYAAEGSRVELPCHLPPGVGTPSLLIaKWT--PPGGGPELPVAGKS--------------------GNFTLHLEAVG 318
Cdd:pfam07686   3 PREVTVALGGSVTLPCTYSSSMSEASTSV-YWYrqPPGKGPTFLIAYYSngseegvkkgrfsgrgdpsnGDGSLTIQNLT 81

                          90       100
                  ....*....|....*....|....*..
gi 6678654    319 LAQAGTYTCSIHLQG-QQLNATVTLAV 344
Cdd:pfam07686  82 LSDSGTYTCAVIPSGeGVFGKGTRLTV 108
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 168-246 4.98e-06

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 44.88  E-value: 4.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678654    168 IASPSGVLKLSDWVLLNCSFSRPDRPVSVHWFQGQNRVP-----VYNSPRHFLAEtfLLLPQVSPLDSGTWGCVLTYRDG 242
Cdd:pfam00047   1 SAPPTVTVLEGDSATLTCSASTGSPGPDVTWSKEGGTLIeslkvKHDNGRTTQSS--LLISNVTKEDAGTYTCVVNNPGG 78


                  ....
gi 6678654    243 FNVS 246
Cdd:pfam00047  79 SATL 82
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 261-327 6.00e-05

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 41.40  E-value: 6.00e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6678654    261 PLTVYAAEGSRVELPCHLppgVGTPSLLIaKWTPPGG----GPELPVAGKSGNFTLHLEAVGLAQAGTYTC 327
Cdd:pfam13927   8 PSSVTVREGETVTLTCEA---TGSPPPTI-TWYKNGEpissGSTRSRSLSGSNSTLTISNVTRSDAGTYTC 74
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 259-330 5.84e-04

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 39.10  E-value: 5.84e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6678654    259 VAPLTVYAAEGSRVELPCHlppGVGTPSLLIAKW-----TPPGGGPELPVAGKSGNFTLHLEAVGLAQAGTYTCSIH 330
Cdd:pfam00047   1 SAPPTVTVLEGDSATLTCS---ASTGSPGPDVTWskeggTLIESLKVKHDNGRTTQSSLLISNVTKEDAGTYTCVVN 74
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 181-248 1.42e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 37.31  E-value: 1.42e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678654  181 VLLNCSFSRPDRPvSVHWFQGQNRVP--VYNSPRHFLAETFLLLPQVSPLDSGTWGCVLTYRDGFNVSIT 248
Cdd:cd00096   1 VTLTCSASGNPPP-TITWYKNGKPLPpsSRDSRRSELGNGTLTISNVTLEDSGTYTCVASNSAGGSASAS 69
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 258-341 5.92e-03

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 36.22  E-value: 5.92e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678654  258 PVAPLTVYAAEGSRVELPCHLPPGVGTPSLLIAKW-------------TPPGGGPELPVAGKSGNFTLHLEAVGLAQAGT 324
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWgsegcqtlvssegVVPGGRISLTDDPDNGVFTVTLNQLRKEDAGW 80

                        90       100
                ....*....|....*....|
gi 6678654  325 YTCSI---HLQGQQLNATVT 341
Cdd:cd05716  81 YWCGVgddGDRGLTVQVKLV 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH