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Conserved domains on  [gi|6755995|ref|NP_035845|]
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WD repeat-containing protein 1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11525814)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-389 2.36e-54

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 186.39  E-value: 2.36e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995   54 YTEHAHQVVVAKYAPSGFYIASGDISGKLRIWDTTQKEhlLKYEYQPFAGKIKDIAWTEDSKRIAVVGEgrekFGAVFLW 133
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTLKGHTGPVRDVAASADGTYLASGSS----DKTIRLW 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  134 D--TGSSVGEITGHNKVINSVDIKQTRPYrLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADG 211
Cdd:cd00200  79 DleTGECVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDG 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  212 QIFIYDGKTGEKVCALgesKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVNVnsvvstfpmgsnvldqqlgclwqkdh 291
Cdd:cd00200 158 TIKLWDLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST-------------------------- 208

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  292 llsislsgyinyldknnpSKPLRVIKGHSKSIQCLTVHRNGgkSYIYSGSHDGHINYWDSETGEnDSFSGKGHTNQVSRM 371
Cdd:cd00200 209 ------------------GKCLGTLRGHENGVNSVAFSPDG--YLLASGSEDGTIRVWDLRTGE-CVQTLSGHTNSVTSL 267

                       330
                ....*....|....*....
gi 6755995  372 TVNESEQ-LVSCSMDDTVR 389
Cdd:cd00200 268 AWSPDGKrLASGSADGTIR 286
WD40 COG2319
WD40 repeat [General function prediction only];
129-605 8.91e-51

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 180.49  E-value: 8.91e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  129 AVFLWDTGSSVGEITGHNKVINSVDIKQTRPYRLATGSDDNCAAFFEGPPfKFKFTIGDHSRFVNCVRFSPDGNRFATAS 208
Cdd:COG2319  19 ALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG-ALLATLLGHTAAVLSVAFSPDGRLLASAS 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  209 ADGQIFIYDGKTGEkvcALGESKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVNvnsvvstfpmgsnvldqqlgclwq 288
Cdd:COG2319  98 ADGTVRLWDLATGL---LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA------------------------ 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  289 kdhllsislSGyinyldknnpsKPLRVIKGHSKSIQCLTVHRNGgkSYIYSGSHDGHINYWDSETGEnDSFSGKGHTNQV 368
Cdd:COG2319 151 ---------TG-----------KLLRTLTGHSGAVTSVAFSPDG--KLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAV 207

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  369 SRMTVN-ESEQLVSCSMDDTVRYTNLTlrdySGQGVVKLdvqpkcvavgpggytvvvcigqivllkdqkkcfsidnPGYE 447
Cdd:COG2319 208 RSVAFSpDGKLLASGSADGTVRLWDLA----TGKLLRTL-------------------------------------TGHS 246

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  448 PEV--VAVHPGGDTVAVGGTDGNVRVYSilASTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGySEN 525
Cdd:COG2319 247 GSVrsVAFSPDGRLLASGSADGTVRLWD--LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG-KLL 323

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  526 NVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETKVKIQdAHRlHHVSSLAWL-DEHTLVTTSHDASVKEWTI 604
Cdd:COG2319 324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT-GHT-GAVTSVAFSpDGRTLASGSADGTVRLWDL 401


                .
gi 6755995  605 T 605
Cdd:COG2319 402 A 402
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-389 2.36e-54

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 186.39  E-value: 2.36e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995   54 YTEHAHQVVVAKYAPSGFYIASGDISGKLRIWDTTQKEhlLKYEYQPFAGKIKDIAWTEDSKRIAVVGEgrekFGAVFLW 133
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTLKGHTGPVRDVAASADGTYLASGSS----DKTIRLW 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  134 D--TGSSVGEITGHNKVINSVDIKQTRPYrLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADG 211
Cdd:cd00200  79 DleTGECVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDG 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  212 QIFIYDGKTGEKVCALgesKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVNVnsvvstfpmgsnvldqqlgclwqkdh 291
Cdd:cd00200 158 TIKLWDLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST-------------------------- 208

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  292 llsislsgyinyldknnpSKPLRVIKGHSKSIQCLTVHRNGgkSYIYSGSHDGHINYWDSETGEnDSFSGKGHTNQVSRM 371
Cdd:cd00200 209 ------------------GKCLGTLRGHENGVNSVAFSPDG--YLLASGSEDGTIRVWDLRTGE-CVQTLSGHTNSVTSL 267

                       330
                ....*....|....*....
gi 6755995  372 TVNESEQ-LVSCSMDDTVR 389
Cdd:cd00200 268 AWSPDGKrLASGSADGTIR 286
WD40 COG2319
WD40 repeat [General function prediction only];
40-389 4.73e-54

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 189.35  E-value: 4.73e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995   40 VILRNIDNPAIADIYTEHAHQVVVAKYAPSGFYIASGDISGKLRIWDTTQKEHLLkyEYQPFAGKIKDIAWTEDSKRIAV 119
Cdd:COG2319  60 LLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLR--TLTGHTGAVRSVAFSPDGKTLAS 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  120 VGEGrekfGAVFLWD--TGSSVGEITGHNKVINSVDIkqtRP--YRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCV 195
Cdd:COG2319 138 GSAD----GTVRLWDlaTGKLLRTLTGHSGAVTSVAF---SPdgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 210

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  196 RFSPDGNRFATASADGQIFIYDGKTGEKVCALgesKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVNVNSVVSTFPMG 275
Cdd:COG2319 211 AFSPDGKLLASGSADGTVRLWDLATGKLLRTL---TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH 287

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  276 SNVLdqqLGCLWQKD--HLLSISLSGYINYLDKNNPsKPLRVIKGHSKSIQCLTVHRNGgkSYIYSGSHDGHINYWDSET 353
Cdd:COG2319 288 SGGV---NSVAFSPDgkLLASGSDDGTVRLWDLATG-KLLRTLTGHTGAVRSVAFSPDG--KTLASGSDDGTVRLWDLAT 361

                       330       340       350
                ....*....|....*....|....*....|....*..
gi 6755995  354 GEnDSFSGKGHTNQVSRMTVN-ESEQLVSCSMDDTVR 389
Cdd:COG2319 362 GE-LLRTLTGHTGAVTSVAFSpDGRTLASGSADGTVR 397
WD40 COG2319
WD40 repeat [General function prediction only];
129-605 8.91e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 180.49  E-value: 8.91e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  129 AVFLWDTGSSVGEITGHNKVINSVDIKQTRPYRLATGSDDNCAAFFEGPPfKFKFTIGDHSRFVNCVRFSPDGNRFATAS 208
Cdd:COG2319  19 ALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG-ALLATLLGHTAAVLSVAFSPDGRLLASAS 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  209 ADGQIFIYDGKTGEkvcALGESKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVNvnsvvstfpmgsnvldqqlgclwq 288
Cdd:COG2319  98 ADGTVRLWDLATGL---LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA------------------------ 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  289 kdhllsislSGyinyldknnpsKPLRVIKGHSKSIQCLTVHRNGgkSYIYSGSHDGHINYWDSETGEnDSFSGKGHTNQV 368
Cdd:COG2319 151 ---------TG-----------KLLRTLTGHSGAVTSVAFSPDG--KLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAV 207

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  369 SRMTVN-ESEQLVSCSMDDTVRYTNLTlrdySGQGVVKLdvqpkcvavgpggytvvvcigqivllkdqkkcfsidnPGYE 447
Cdd:COG2319 208 RSVAFSpDGKLLASGSADGTVRLWDLA----TGKLLRTL-------------------------------------TGHS 246

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  448 PEV--VAVHPGGDTVAVGGTDGNVRVYSilASTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGySEN 525
Cdd:COG2319 247 GSVrsVAFSPDGRLLASGSADGTVRLWD--LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG-KLL 323

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  526 NVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETKVKIQdAHRlHHVSSLAWL-DEHTLVTTSHDASVKEWTI 604
Cdd:COG2319 324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT-GHT-GAVTSVAFSpDGRTLASGSADGTVRLWDL 401


                .
gi 6755995  605 T 605
Cdd:COG2319 402 A 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 312-602 2.75e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 123.21  E-value: 2.75e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  312 PLRVIKGHSKSIQCLTVHRNGgkSYIYSGSHDGHINYWDSETGEnDSFSGKGHTNQVSR-MTVNESEQLVSCSMDDTVRY 390
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDG--KLLATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDvAASADGTYLASGSSDKTIRL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  391 TNLT----LRDYSG--QGVvkldvqpKCVAVGPGGYTVVVCI--GQIVL--LKDQKKCFSIDNPGYEPEVVAVHPGGDTV 460
Cdd:cd00200  78 WDLEtgecVRTLTGhtSYV-------SSVAFSPDGRILSSSSrdKTIKVwdVETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  461 AVGGTDGNVRVYSIlaSTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGySENNVFYGHHAKIVCLAW 540
Cdd:cd00200 151 ASSSQDGTIKLWDL--RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG-KCLGTLRGHENGVNSVAF 227

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6755995  541 SPDNEHFASGGMDMMVYVWTLSDPETKVKIQdAHRlHHVSSLAWL-DEHTLVTTSHDASVKEW 602
Cdd:cd00200 228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLS-GHT-NSVTSLAWSpDGKRLASGSADGTIRIW 288
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 128-276 3.23e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 63.18  E-value: 3.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995   128 GAVFLWDTGSS--VGEITGHNKVINSVDIKQTRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRfVNCVRFSPD-GNRF 204
Cdd:PLN00181 555 GVVQVWDVARSqlVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSEsGRSL 633

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6755995   205 ATASADGQIFIYDGKTGE-KVCAL-GESKahdggiyAISWSP--DSTHLLSASGDKTSKIWDVNVN-SVVSTFPMGS 276
Cdd:PLN00181 634 AFGSADHKVYYYDLRNPKlPLCTMiGHSK-------TVSYVRfvDSSTLVSSSTDNTLKLWDLSMSiSGINETPLHS 703
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 178-217 3.22e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.62  E-value: 3.22e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 6755995     178 PFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIFIYD 217
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 526-559 1.64e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.64e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 6755995     526 NVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVW 559
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
179-217 1.75e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.75e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 6755995    179 FKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIFIYD 217
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
527-559 8.82e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 8.82e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 6755995    527 VFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVW 559
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 460-605 1.19e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.08  E-value: 1.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995   460 VAVGGTDGNVRVYSILASTLKDEGKllEAKGPVTDVAYSH-DGAFLAVCDASKVVTVFSVADGYSENNVfyGHHAKIVCL 538
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMK--EHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTI--KTKANICCV 623

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6755995   539 AWSPDN-EHFASGGMDMMVYVWTLSDPETKVKIQDAHRlHHVSSLAWLDEHTLVTTSHDASVKEWTIT 605
Cdd:PLN00181 624 QFPSESgRSLAFGSADHKVYYYDLRNPKLPLCTMIGHS-KTVSYVRFVDSSTLVSSSTDNTLKLWDLS 690
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-389 2.36e-54

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 186.39  E-value: 2.36e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995   54 YTEHAHQVVVAKYAPSGFYIASGDISGKLRIWDTTQKEhlLKYEYQPFAGKIKDIAWTEDSKRIAVVGEgrekFGAVFLW 133
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTLKGHTGPVRDVAASADGTYLASGSS----DKTIRLW 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  134 D--TGSSVGEITGHNKVINSVDIKQTRPYrLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADG 211
Cdd:cd00200  79 DleTGECVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDG 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  212 QIFIYDGKTGEKVCALgesKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVNVnsvvstfpmgsnvldqqlgclwqkdh 291
Cdd:cd00200 158 TIKLWDLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST-------------------------- 208

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  292 llsislsgyinyldknnpSKPLRVIKGHSKSIQCLTVHRNGgkSYIYSGSHDGHINYWDSETGEnDSFSGKGHTNQVSRM 371
Cdd:cd00200 209 ------------------GKCLGTLRGHENGVNSVAFSPDG--YLLASGSEDGTIRVWDLRTGE-CVQTLSGHTNSVTSL 267

                       330
                ....*....|....*....
gi 6755995  372 TVNESEQ-LVSCSMDDTVR 389
Cdd:cd00200 268 AWSPDGKrLASGSADGTIR 286
WD40 COG2319
WD40 repeat [General function prediction only];
40-389 4.73e-54

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 189.35  E-value: 4.73e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995   40 VILRNIDNPAIADIYTEHAHQVVVAKYAPSGFYIASGDISGKLRIWDTTQKEHLLkyEYQPFAGKIKDIAWTEDSKRIAV 119
Cdd:COG2319  60 LLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLR--TLTGHTGAVRSVAFSPDGKTLAS 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  120 VGEGrekfGAVFLWD--TGSSVGEITGHNKVINSVDIkqtRP--YRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCV 195
Cdd:COG2319 138 GSAD----GTVRLWDlaTGKLLRTLTGHSGAVTSVAF---SPdgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 210

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  196 RFSPDGNRFATASADGQIFIYDGKTGEKVCALgesKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVNVNSVVSTFPMG 275
Cdd:COG2319 211 AFSPDGKLLASGSADGTVRLWDLATGKLLRTL---TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH 287

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  276 SNVLdqqLGCLWQKD--HLLSISLSGYINYLDKNNPsKPLRVIKGHSKSIQCLTVHRNGgkSYIYSGSHDGHINYWDSET 353
Cdd:COG2319 288 SGGV---NSVAFSPDgkLLASGSDDGTVRLWDLATG-KLLRTLTGHTGAVRSVAFSPDG--KTLASGSDDGTVRLWDLAT 361

                       330       340       350
                ....*....|....*....|....*....|....*..
gi 6755995  354 GEnDSFSGKGHTNQVSRMTVN-ESEQLVSCSMDDTVR 389
Cdd:COG2319 362 GE-LLRTLTGHTGAVTSVAFSpDGRTLASGSADGTVR 397
WD40 COG2319
WD40 repeat [General function prediction only];
129-605 8.91e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 180.49  E-value: 8.91e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  129 AVFLWDTGSSVGEITGHNKVINSVDIKQTRPYRLATGSDDNCAAFFEGPPfKFKFTIGDHSRFVNCVRFSPDGNRFATAS 208
Cdd:COG2319  19 ALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG-ALLATLLGHTAAVLSVAFSPDGRLLASAS 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  209 ADGQIFIYDGKTGEkvcALGESKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVNvnsvvstfpmgsnvldqqlgclwq 288
Cdd:COG2319  98 ADGTVRLWDLATGL---LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA------------------------ 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  289 kdhllsislSGyinyldknnpsKPLRVIKGHSKSIQCLTVHRNGgkSYIYSGSHDGHINYWDSETGEnDSFSGKGHTNQV 368
Cdd:COG2319 151 ---------TG-----------KLLRTLTGHSGAVTSVAFSPDG--KLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAV 207

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  369 SRMTVN-ESEQLVSCSMDDTVRYTNLTlrdySGQGVVKLdvqpkcvavgpggytvvvcigqivllkdqkkcfsidnPGYE 447
Cdd:COG2319 208 RSVAFSpDGKLLASGSADGTVRLWDLA----TGKLLRTL-------------------------------------TGHS 246

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  448 PEV--VAVHPGGDTVAVGGTDGNVRVYSilASTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGySEN 525
Cdd:COG2319 247 GSVrsVAFSPDGRLLASGSADGTVRLWD--LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG-KLL 323

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  526 NVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETKVKIQdAHRlHHVSSLAWL-DEHTLVTTSHDASVKEWTI 604
Cdd:COG2319 324 RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT-GHT-GAVTSVAFSpDGRTLASGSADGTVRLWDL 401


                .
gi 6755995  605 T 605
Cdd:COG2319 402 A 402
WD40 COG2319
WD40 repeat [General function prediction only];
67-563 8.40e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 177.80  E-value: 8.40e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995   67 APSGFYIASGDISGKLRIWDTTQKEHLLkyEYQPFAGKIKDIAWTEDSKRIAVVGEGREkfGAVFLWDTGSSVGEITGHN 146
Cdd:COG2319   3 SADGAALAAASADLALALLAAALGALLL--LLLGLAAAVASLAASPDGARLAAGAGDLT--LLLLDAAAGALLATLLGHT 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  147 KVINSVDIKQTRPyRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIFIYDGKTGEKVCA 226
Cdd:COG2319  79 AAVLSVAFSPDGR-LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  227 LgesKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVnvnsvvstfpmgsnvldqqlgclwqkdhllsisLSGyinyldk 306
Cdd:COG2319 158 L---TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL---------------------------------ATG------- 194

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  307 nnpsKPLRVIKGHSKSIQCLTVHRNGgkSYIYSGSHDGHINYWDSETGEnDSFSGKGHTNQVSRMTVN-ESEQLVSCSMD 385
Cdd:COG2319 195 ----KLLRTLTGHTGAVRSVAFSPDG--KLLASGSADGTVRLWDLATGK-LLRTLTGHSGSVRSVAFSpDGRLLASGSAD 267

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  386 DTVRytnltLRDYSGQgvvkldvqpKCVAVGPGGYTVVVCigqivllkdqkkcfsidnpgyepevVAVHPGGDTVAVGGT 465
Cdd:COG2319 268 GTVR-----LWDLATG---------ELLRTLTGHSGGVNS-------------------------VAFSPDGKLLASGSD 308

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  466 DGNVRVYSIlastlkDEGKLLEA----KGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGySENNVFYGHHAKIVCLAWS 541
Cdd:COG2319 309 DGTVRLWDL------ATGKLLRTltghTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG-ELLRTLTGHTGAVTSVAFS 381

                       490       500
                ....*....|....*....|..
gi 6755995  542 PDNEHFASGGMDMMVYVWTLSD 563
Cdd:COG2319 382 PDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 182-559 3.72e-42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 153.64  E-value: 3.72e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  182 KFTIGDHSRFVNCVRFSPDGNRFATASADGQIFIYDGKTGEKVCALgesKAHDGGIYAISWSPDSTHLLSASGDKTSKIW 261
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL---KGHTGPVRDVAASADGTYLASGSSDKTIRLW 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  262 DVNVNSVVSTFpmgsnvldqqlgclwqkdhllsislsgyinyldknnpskplrviKGHSKSIQCLTVHRNGgkSYIYSGS 341
Cdd:cd00200  79 DLETGECVRTL--------------------------------------------TGHTSYVSSVAFSPDG--RILSSSS 112

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  342 HDGHINYWDSETGENdSFSGKGHTNQVSRMTVNESEQLVSCSMDDtvrytnltlrdysgqGVVKL-DV-QPKCVAVGPGG 419
Cdd:cd00200 113 RDKTIKVWDVETGKC-LTTLRGHTDWVNSVAFSPDGTFVASSSQD---------------GTIKLwDLrTGKCVATLTGH 176

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  420 YTVVVCigqivllkdqkkcfsidnpgyepevVAVHPGGDTVAVGGTDGNVRVYSILASTLKdegKLLEAK-GPVTDVAYS 498
Cdd:cd00200 177 TGEVNS-------------------------VAFSPDGEKLLSSSSDGTIKLWDLSTGKCL---GTLRGHeNGVNSVAFS 228

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6755995  499 HDGAFLAVCDASKVVTVFSVADGySENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVW 559
Cdd:cd00200 229 PDGYLLASGSEDGTIRVWDLRTG-ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
40-264 1.35e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 143.90  E-value: 1.35e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995   40 VILRNIDNPAIADIYTEHAHQVVVAKYAPSGFYIASGDISGKLRIWDTTQKEHLlkYEYQPFAGKIKDIAWTEDSKRIAV 119
Cdd:COG2319 186 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL--RTLTGHSGSVRSVAFSPDGRLLAS 263

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  120 VGEGrekfGAVFLWD--TGSSVGEITGHNKVINSVDIkqtRP--YRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCV 195
Cdd:COG2319 264 GSAD----GTVRLWDlaTGELLRTLTGHSGGVNSVAF---SPdgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6755995  196 RFSPDGNRFATASADGQIFIYDGKTGEKVCALgesKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVN 264
Cdd:COG2319 337 AFSPDGKTLASGSDDGTVRLWDLATGELLRTL---TGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 38-262 6.40e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 127.84  E-value: 6.40e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995   38 KCVILRNIDNPAIADIYTEHAHQVVVAKYAPSGFYIASGDISGKLRIWDTTQKEhlLKYEYQPFAGKIKDIAWTEDSKRI 117
Cdd:cd00200  73 KTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK--CLTTLRGHTDWVNSVAFSPDGTFV 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  118 AVVGEGrekfGAVFLWD--TGSSVGEITGHNKVINSVDIKQTRpYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCV 195
Cdd:cd00200 151 ASSSQD----GTIKLWDlrTGKCVATLTGHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSV 225

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6755995  196 RFSPDGNRFATASADGQIFIYDGKTGEKVCALgesKAHDGGIYAISWSPDSTHLLSASGDKTSKIWD 262
Cdd:cd00200 226 AFSPDGYLLASGSEDGTIRVWDLRTGECVQTL---SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 312-602 2.75e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 123.21  E-value: 2.75e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  312 PLRVIKGHSKSIQCLTVHRNGgkSYIYSGSHDGHINYWDSETGEnDSFSGKGHTNQVSR-MTVNESEQLVSCSMDDTVRY 390
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDG--KLLATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDvAASADGTYLASGSSDKTIRL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  391 TNLT----LRDYSG--QGVvkldvqpKCVAVGPGGYTVVVCI--GQIVL--LKDQKKCFSIDNPGYEPEVVAVHPGGDTV 460
Cdd:cd00200  78 WDLEtgecVRTLTGhtSYV-------SSVAFSPDGRILSSSSrdKTIKVwdVETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  461 AVGGTDGNVRVYSIlaSTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGySENNVFYGHHAKIVCLAW 540
Cdd:cd00200 151 ASSSQDGTIKLWDL--RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG-KCLGTLRGHENGVNSVAF 227

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6755995  541 SPDNEHFASGGMDMMVYVWTLSDPETKVKIQdAHRlHHVSSLAWL-DEHTLVTTSHDASVKEW 602
Cdd:cd00200 228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLS-GHT-NSVTSLAWSpDGKRLASGSADGTIRIW 288
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 128-276 3.23e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 63.18  E-value: 3.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995   128 GAVFLWDTGSS--VGEITGHNKVINSVDIKQTRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRfVNCVRFSPD-GNRF 204
Cdd:PLN00181 555 GVVQVWDVARSqlVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSEsGRSL 633

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6755995   205 ATASADGQIFIYDGKTGE-KVCAL-GESKahdggiyAISWSP--DSTHLLSASGDKTSKIWDVNVN-SVVSTFPMGS 276
Cdd:PLN00181 634 AFGSADHKVYYYDLRNPKlPLCTMiGHSK-------TVSYVRfvDSSTLVSSSTDNTLKLWDLSMSiSGINETPLHS 703
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 202-366 2.19e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.40  E-value: 2.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995   202 NRFATASADGQIFIYDGKTGEKVCalgESKAHDGGIYAISWSP-DSTHLLSASGDKTSKIWDVNVNSVVSTFPMGSNVLD 280
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVT---EMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICC 622

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995   281 QQlgclWQKDHLLSISLSGY---INYLDKNNPSKPLRVIKGHSKSIQCLtvhRNGGKSYIYSGSHDGHINYWD---SETG 354
Cdd:PLN00181 623 VQ----FPSESGRSLAFGSAdhkVYYYDLRNPKLPLCTMIGHSKTVSYV---RFVDSSTLVSSSTDNTLKLWDlsmSISG 695

                        170
                 ....*....|....
gi 6755995   355 ENDS--FSGKGHTN 366
Cdd:PLN00181 696 INETplHSFMGHTN 709
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 178-217 3.22e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.62  E-value: 3.22e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 6755995     178 PFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIFIYD 217
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 231-262 1.07e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 1.07e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 6755995     231 KAHDGGIYAISWSPDSTHLLSASGDKTSKIWD 262
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 526-559 1.64e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.64e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 6755995     526 NVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVW 559
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
179-217 1.75e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.75e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 6755995    179 FKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIFIYD 217
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
231-262 5.79e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 5.79e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 6755995    231 KAHDGGIYAISWSPDSTHLLSASGDKTSKIWD 262
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 309-350 7.51e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 7.51e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 6755995     309 PSKPLRVIKGHSKSIQCLTVHRNGgkSYIYSGSHDGHINYWD 350
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDG--KYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
527-559 8.82e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 8.82e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 6755995    527 VFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVW 559
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 195-267 1.83e-05

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 48.11  E-value: 1.83e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6755995   195 VRFSPDGNRFATAS-ADG--QIFIYDGKTGEKVCALGESKahDGGIYAISWSPDSTHLlsASGDKTSKIWDVNVNS 267
Cdd:COG4946  348 PAWSPDGKSIAYFSdASGeyELYIAPADGSGEPKQLTLGD--LGRVFNPVWSPDGKKI--AFTDNRGRLWVVDLAS 419
WD40 pfam00400
WD domain, G-beta repeat;
310-350 2.29e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 2.29e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 6755995    310 SKPLRVIKGHSKSIQCLTVHRNGgkSYIYSGSHDGHINYWD 350
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDG--KLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 460-605 1.19e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.08  E-value: 1.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995   460 VAVGGTDGNVRVYSILASTLKDEGKllEAKGPVTDVAYSH-DGAFLAVCDASKVVTVFSVADGYSENNVfyGHHAKIVCL 538
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMK--EHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTI--KTKANICCV 623

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6755995   539 AWSPDN-EHFASGGMDMMVYVWTLSDPETKVKIQDAHRlHHVSSLAWLDEHTLVTTSHDASVKEWTIT 605
Cdd:PLN00181 624 QFPSESgRSLAFGSADHKVYYYDLRNPKLPLCTMIGHS-KTVSYVRFVDSSTLVSSSTDNTLKLWDLS 690
PTZ00421 PTZ00421
coronin; Provisional
 195-335 1.58e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.50  E-value: 1.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995   195 VRFSP-DGNRFATASADGQIFIY----DGKTGEKVCALGESKAHDGGIYAISWSPDSTHLLSASG-DKTSKIWDVNVNSV 268
Cdd:PTZ00421  81 VAFNPfDPQKLFTASEDGTIMGWgipeEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGaDMVVNVWDVERGKA 160

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6755995   269 VSTFpmgSNVLDQQLGCLWQKDHLLSISLSgyinyldknnPSKPLRVIKGHSKSIQCLTVHRNGGKS 335
Cdd:PTZ00421 161 VEVI---KCHSDQITSLEWNLDGSLLCTTS----------KDKKLNIIDPRDGTIVSSVEAHASAKS 214
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 187-395 2.07e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.31  E-value: 2.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995   187 DHSRFVNCVRFSPDGNRFATASADGQIFIYDG----KTGEKVCALGESKAHDGGIYAISW-SPDSTHLLSASGDKTSKIW 261
Cdd:PLN00181 481 NSSNLVCAIGFDRDGEFFATAGVNKKIKIFECesiiKDGRDIHYPVVELASRSKLSGICWnSYIKSQVASSNFEGVVQVW 560

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995   262 DVNVNSVVSTfpmgsnvLDQQLGCLWQKDH-------LLSISLSGYINyLDKNNPSKPLRVIKGHSkSIQCLTVHRNGGK 334
Cdd:PLN00181 561 DVARSQLVTE-------MKEHEKRVWSIDYssadptlLASGSDDGSVK-LWSINQGVSIGTIKTKA-NICCVQFPSESGR 631

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6755995   335 SYIYsGSHDGHINYWDSETGENDSFSGKGHTNQVSRMTVNESEQLVSCSMDDTVRYTNLTL 395
Cdd:PLN00181 632 SLAF-GSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSM 691
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 196-276 3.08e-04

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 41.58  E-value: 3.08e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995  196 RFSPDGNRFATASADG---QIFIYDGKTgekvcalGESKAHDGGIYAISWSPDSTHLL-SASGDKTSKIWDVNVNSVVST 271
Cdd:COG0823  81 SWSPDGKRLAFVSRSDgrfDIYVLDLDG-------GAPRRLTDGPGSPSWSPDGRRIVfSSDRGGRPDLYVVDLDGRKRR 153


                ....*
gi 6755995  272 FPMGS 276
Cdd:COG0823 154 LTPAS 158
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 192-243 6.88e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.18  E-value: 6.88e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 6755995    192 VNCVRFSPDGNRFATASADGQIFIYDGKTGEKVCALgesKAHDGGIYAISWS 243
Cdd:pfam12894  41 VTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHF---SAGSDLITCLGWG 89
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 182-246 1.28e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 41.95  E-value: 1.28e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6755995   182 KFTIGDHSRFVNcVRFSPDGNRFATASADGQIFIYDGKTGE--KVcalgESKAHDGGIYAISWSPDS 246
Cdd:COG4946  382 QLTLGDLGRVFN-PVWSPDGKKIAFTDNRGRLWVVDLASGKvrKV----DTDGYGDGISDLAWSPDS 443
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 168-264 1.76e-03

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 39.95  E-value: 1.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995    168 DNCAAFFEgPPFKFKFTIGDHSRfvNCVRFSPDGNRFATA---SADGQIFIYDGKTGEKVCALGESKAHDggiyaISWSP 244
Cdd:pfam08662  82 PAKVSFFD-LKGNVIHSFGEQPR--NTIFWSPFGRLVLLAgfgNLAGDIEFWDVVNKKKIATAEASNATL-----CEWSP 153

                          90       100
                  ....*....|....*....|....*.
gi 6755995    245 DSTHLLSASG------DKTSKIWDVN 264
Cdd:pfam08662 154 DGRYFLTATTaprlrvDNGFKIWHYN 179
PTZ00421 PTZ00421
coronin; Provisional
 188-297 1.99e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.03  E-value: 1.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6755995   188 HSRFVNCVRFSPDG-NRFATASADGQIFIYDGKTGEKVCALgesKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVNVN 266
Cdd:PTZ00421 124 HTKKVGIVSFHPSAmNVLASAGADMVVNVWDVERGKAVEVI---KCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200

                         90       100       110
                 ....*....|....*....|....*....|.
gi 6755995   267 SVVSTFPMGSNVLDQQlgCLWQKDHLLSISL 297
Cdd:PTZ00421 201 TIVSSVEAHASAKSQR--CLWAKRKDLIITL 229
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 205-276 6.90e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.10  E-value: 6.90e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6755995    205 ATASADGQIFIYDGKtGEKVCALGESKaHDGGIYAISWSPDSTHLLSASGDKTSKIWDVNVNSVVSTFPMGS 276
Cdd:pfam12894  11 ALATEDGELLLHRLN-WQRVWTLSPDK-EDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGS 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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