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Conserved domains on  [gi|112380630|ref|NP_036266|]
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leiomodin-1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 340-450 8.12e-12

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 67.51  E-value: 8.12e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630 340 SDCITNEILVRFTEALEFNTVVKLFALANTRADDHVAFAIAIMLKANKTITSLNLDSNHITGKGILAIFRALLQNNTLTE 419
Cdd:COG5238  189 CNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVET 268

                         90       100       110
                 ....*....|....*....|....*....|..
gi 112380630 420 LRF-HNQrhiCGGKTEMEIAKLLKENTTLLKL 450
Cdd:COG5238  269 LYLsGNQ---IGAEGAIALAKALQGNTTLTSL 297
PTZ00121 super family cl31754
MAEBL; Provisional
 75-326 6.08e-07

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.84  E-value: 6.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630   75 ETKKLMQREMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGGLKKSFSRDRDEAGGKSGEKPKEEKI 154
Cdd:PTZ00121 1370 EKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEA 1449

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630  155 IRGIDKGRvRAAVDKKEAGKDGRGEEravATKKEEEKKGSDRNTGLSRDKDKKREEMKevaKKEDDEKVKGERRNTDTRK 234
Cdd:PTZ00121 1450 KKKAEEAK-KAEEAKKKAEEAKKADE---AKKKAEEAKKADEAKKKAEEAKKKADEAK---KAAEAKKKADEAKKAEEAK 1522

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630  235 EGEKMKRAggnTDMKKEDEKVKrgtgnTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPSEGPAKVEEEAA 314
Cdd:PTZ00121 1523 KADEAKKA---EEAKKADEAKK-----AEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARI 1594

                         250
                  ....*....|..
gi 112380630  315 PSIFDEPLERVK 326
Cdd:PTZ00121 1595 EEVMKLYEEEKK 1606
Tropomodulin super family cl12276
Tropomodulin; Tropomodulin is a novel tropomyosin regulatory protein that binds to the end of ...
 13-83 2.94e-06

Tropomodulin; Tropomodulin is a novel tropomyosin regulatory protein that binds to the end of erythrocyte tropomyosin and blocks head-to-tail association of tropomyosin along actin filaments. Limited proteolysis shows this protein is composed of two domains. The amino terminal domain contains the tropomyosin binding function.


The actual alignment was detected with superfamily member pfam03250:

Pssm-ID: 460862  Cd Length: 142  Bit Score: 47.28  E-value: 2.94e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 112380630   13 EDPDIDSLLETLSPEEMEELEKELDVVDPDGS-VPVGLRQRNQTEKQSTGVYNREAMLNFCEKETKKLMQRE 83
Cdd:pfam03250   9 DDIDEDELLKKLSEEELEQLDELLEELDPDNAlLPAGQRQRDQTKKEPTGPFDREKLLHHLEKQALEPKDRE 80
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 340-450 8.12e-12

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 67.51  E-value: 8.12e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630 340 SDCITNEILVRFTEALEFNTVVKLFALANTRADDHVAFAIAIMLKANKTITSLNLDSNHITGKGILAIFRALLQNNTLTE 419
Cdd:COG5238  189 CNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVET 268

                         90       100       110
                 ....*....|....*....|....*....|..
gi 112380630 420 LRF-HNQrhiCGGKTEMEIAKLLKENTTLLKL 450
Cdd:COG5238  269 LYLsGNQ---IGAEGAIALAKALQGNTTLTSL 297
PTZ00121 PTZ00121
MAEBL; Provisional
 75-326 6.08e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.84  E-value: 6.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630   75 ETKKLMQREMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGGLKKSFSRDRDEAGGKSGEKPKEEKI 154
Cdd:PTZ00121 1370 EKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEA 1449

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630  155 IRGIDKGRvRAAVDKKEAGKDGRGEEravATKKEEEKKGSDRNTGLSRDKDKKREEMKevaKKEDDEKVKGERRNTDTRK 234
Cdd:PTZ00121 1450 KKKAEEAK-KAEEAKKKAEEAKKADE---AKKKAEEAKKADEAKKKAEEAKKKADEAK---KAAEAKKKADEAKKAEEAK 1522

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630  235 EGEKMKRAggnTDMKKEDEKVKrgtgnTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPSEGPAKVEEEAA 314
Cdd:PTZ00121 1523 KADEAKKA---EEAKKADEAKK-----AEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARI 1594

                         250
                  ....*....|..
gi 112380630  315 PSIFDEPLERVK 326
Cdd:PTZ00121 1595 EEVMKLYEEEKK 1606
Tropomodulin pfam03250
Tropomodulin; Tropomodulin is a novel tropomyosin regulatory protein that binds to the end of ...
 13-83 2.94e-06

Tropomodulin; Tropomodulin is a novel tropomyosin regulatory protein that binds to the end of erythrocyte tropomyosin and blocks head-to-tail association of tropomyosin along actin filaments. Limited proteolysis shows this protein is composed of two domains. The amino terminal domain contains the tropomyosin binding function.


Pssm-ID: 460862  Cd Length: 142  Bit Score: 47.28  E-value: 2.94e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 112380630   13 EDPDIDSLLETLSPEEMEELEKELDVVDPDGS-VPVGLRQRNQTEKQSTGVYNREAMLNFCEKETKKLMQRE 83
Cdd:pfam03250   9 DDIDEDELLKKLSEEELEQLDELLEELDPDNAlLPAGQRQRDQTKKEPTGPFDREKLLHHLEKQALEPKDRE 80
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 85-330 8.41e-06

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 48.84  E-value: 8.41e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630    85 SMDESKQVETKTDAKNGEERGRDASKkalgPRRDSDLGKEPKRGGLKksfSRDRDEAGGKsGEKPKEEKIIRG-IDKGRV 163
Cdd:TIGR00927  644 RTGEEGERPTEAEGENGEESGGEAEQ----EGETETKGENESEGEIP---AERKGEQEGE-GEIEAKEADHKGeTEAEEV 715

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630   164 RAAVDKKEAGKDGRGEERAVATKKEEEKKGsdrntglsrDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAG 243
Cdd:TIGR00927  716 EHEGETEAEGTEDEGEIETGEEGEEVEDEG---------EGEAEGKHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAG 786

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630   244 GNTDMKKEDEKVKRGT--------------GNTDTKKDDEKVKKNEPLHE------KEAKDDSKTKTPEKQTPSGPTKPS 303
Cdd:TIGR00927  787 EDGEMKGDEGAEGKVEhegeteagekdeheGQSETQADDTEVKDETGEQElnaenqGEAKQDEKGVDGGGGSDGGDSEEE 866

                          250       260
                   ....*....|....*....|....*..
gi 112380630   304 EGPAKVEEEAAPSIFDEPLERVKNNDP 330
Cdd:TIGR00927  867 EEEEEEEEEEEEEEEEEEEEEEENEEP 893
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 137-316 7.85e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 39.23  E-value: 7.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630 137 DRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKKGSDRNTG--------LSRDK---- 204
Cdd:NF033838 229 DREKAEEEAKRRADAKLKEAVEKNVATSEQDKPKRRAKRGVLGEPATPDKKENDAKSSDSSVGeetlpspsLKPEKkvae 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630 205 -DKKREEMKEVAKKEDDEkvkgERRN--TDTRKEGEkMKRAGGNTDMKK--------------EDEKVKRGTGNTDTKKD 267
Cdd:NF033838 309 aEKKVEEAKKKAKDQKEE----DRRNypTNTYKTLE-LEIAESDVKVKEaelelvkeeakeprNEEKIKQAKAKVESKKA 383

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 112380630 268 D----EKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPSegPAKVEEEAAPS 316
Cdd:NF033838 384 EatrlEKIKTDRKKAEEEAKRKAAEEDKVKEKPAEQPQPA--PAPQPEKPAPK 434
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 340-450 8.12e-12

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 67.51  E-value: 8.12e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630 340 SDCITNEILVRFTEALEFNTVVKLFALANTRADDHVAFAIAIMLKANKTITSLNLDSNHITGKGILAIFRALLQNNTLTE 419
Cdd:COG5238  189 CNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVET 268

                         90       100       110
                 ....*....|....*....|....*....|..
gi 112380630 420 LRF-HNQrhiCGGKTEMEIAKLLKENTTLLKL 450
Cdd:COG5238  269 LYLsGNQ---IGAEGAIALAKALQGNTTLTSL 297
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 337-450 6.12e-11

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 64.81  E-value: 6.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630 337 VNNsdCITNEILVRFTEALEFNTVVKLFALANTRADDHVAFAIAIMLKANKTITSLNLDSNHITGKGILAIFRALLQNNT 416
Cdd:COG5238  244 SNN--QIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKT 321

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 112380630 417 LTELRF-HNQrhiCGGKTEMEIAKLLKENTTLLKL 450
Cdd:COG5238  322 LHTLNLaYNG---IGAQGAIALAKALQENTTLHSL 353
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 336-469 1.44e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 54.03  E-value: 1.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630 336 NVNNsdcITNEILVRFTEALEFNTVVKLFALANTRADDHVAFAIAIMLKANKTITSLNLDSNHITGKGILAIFRALLQNN 415
Cdd:COG5238  300 SVNR---IGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNT 376

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 112380630 416 TLTELrfHNQRHICGGKTEMEIAKLLKENT-TLLKLGYHFELAGPRMTVTNLLSR 469
Cdd:COG5238  377 TLREL--NLGKNNIGKQGAEALIDALQTNRlHTLILDGNLIGAEAQQRLEQLLER 429
PTZ00121 PTZ00121
MAEBL; Provisional
 75-326 6.08e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.84  E-value: 6.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630   75 ETKKLMQREMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGGLKKSFSRDRDEAGGKSGEKPKEEKI 154
Cdd:PTZ00121 1370 EKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEA 1449

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630  155 IRGIDKGRvRAAVDKKEAGKDGRGEEravATKKEEEKKGSDRNTGLSRDKDKKREEMKevaKKEDDEKVKGERRNTDTRK 234
Cdd:PTZ00121 1450 KKKAEEAK-KAEEAKKKAEEAKKADE---AKKKAEEAKKADEAKKKAEEAKKKADEAK---KAAEAKKKADEAKKAEEAK 1522

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630  235 EGEKMKRAggnTDMKKEDEKVKrgtgnTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPSEGPAKVEEEAA 314
Cdd:PTZ00121 1523 KADEAKKA---EEAKKADEAKK-----AEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARI 1594

                         250
                  ....*....|..
gi 112380630  315 PSIFDEPLERVK 326
Cdd:PTZ00121 1595 EEVMKLYEEEKK 1606
PTZ00121 PTZ00121
MAEBL; Provisional
 73-311 7.22e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.45  E-value: 7.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630   73 EKETKKLMQREMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKepKRGGLKKSFSRDRDEAGGKSGEKPKEE 152
Cdd:PTZ00121 1460 EEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKK--KADEAKKAEEAKKADEAKKAEEAKKAD 1537

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630  153 KIIRGIDKGR---------VRAAVDKKEAGKDGRGEE-------RAVATKKEEEKKGSDRNTGLSRDKDKKREEmkevAK 216
Cdd:PTZ00121 1538 EAKKAEEKKKadelkkaeeLKKAEEKKKAEEAKKAEEdknmalrKAEEAKKAEEARIEEVMKLYEEEKKMKAEE----AK 1613

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630  217 KEDDEKVKGE--RRNTDTRKEGEKMKRAggNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEplHEKEAKDDSKTKTPEKQ 294
Cdd:PTZ00121 1614 KAEEAKIKAEelKKAEEEKKKVEQLKKK--EAEEKKKAEELKKAEEENKIKAAEEAKKAEE--DKKKAEEAKKAEEDEKK 1689

                         250
                  ....*....|....*..
gi 112380630  295 TPSGPTKPSEGPAKVEE 311
Cdd:PTZ00121 1690 AAEALKKEAEEAKKAEE 1706
PTZ00121 PTZ00121
MAEBL; Provisional
 50-313 1.23e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 51.68  E-value: 1.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630   50 RQRNQTEKQSTGVYNREAMLNFCEKETKKLMQREMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGG 129
Cdd:PTZ00121 1236 KKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAK 1315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630  130 LKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDKKRE 209
Cdd:PTZ00121 1316 KADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADE 1395

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630  210 EMK---EVAKKEDDEKVKGE--RRNTDTRKEGEKMKRAggnTDMKKEDEKVKRGtgnTDTKKDDEKVKKNEPL----HEK 280
Cdd:PTZ00121 1396 AKKkaeEDKKKADELKKAAAakKKADEAKKKAEEKKKA---DEAKKKAEEAKKA---DEAKKKAEEAKKAEEAkkkaEEA 1469

                         250       260       270
                  ....*....|....*....|....*....|...
gi 112380630  281 EAKDDSKTKTPEKQTPSGPTKPSEGPAKVEEEA 313
Cdd:PTZ00121 1470 KKADEAKKKAEEAKKADEAKKKAEEAKKKADEA 1502
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 358-451 2.44e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 50.17  E-value: 2.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630 358 NTVVKLFALANTRADDHVAFAIAIMLKANKTITSLNLDSNHITGKGILAIFRALLQNNTLTELRFHNQRHICGGKteMEI 437
Cdd:COG5238  179 NNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGV--IAL 256

                         90
                 ....*....|....
gi 112380630 438 AKLLKENTTLLKLG 451
Cdd:COG5238  257 AEALKNNTTVETLY 270
PTZ00121 PTZ00121
MAEBL; Provisional
 74-312 2.68e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.91  E-value: 2.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630   74 KETKKLMQREMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGGLKKSFSRDRDEAGGKSGEKPKEEK 153
Cdd:PTZ00121 1428 EEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAE 1507

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630  154 IIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTR 233
Cdd:PTZ00121 1508 AKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAK 1587

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630  234 KEGEK-----MKRAGGNTDMKKEDEKV--KRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPSEGP 306
Cdd:PTZ00121 1588 KAEEArieevMKLYEEEKKMKAEEAKKaeEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEA 1667


                  ....*.
gi 112380630  307 AKVEEE 312
Cdd:PTZ00121 1668 KKAEED 1673
Tropomodulin pfam03250
Tropomodulin; Tropomodulin is a novel tropomyosin regulatory protein that binds to the end of ...
 13-83 2.94e-06

Tropomodulin; Tropomodulin is a novel tropomyosin regulatory protein that binds to the end of erythrocyte tropomyosin and blocks head-to-tail association of tropomyosin along actin filaments. Limited proteolysis shows this protein is composed of two domains. The amino terminal domain contains the tropomyosin binding function.


Pssm-ID: 460862  Cd Length: 142  Bit Score: 47.28  E-value: 2.94e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 112380630   13 EDPDIDSLLETLSPEEMEELEKELDVVDPDGS-VPVGLRQRNQTEKQSTGVYNREAMLNFCEKETKKLMQRE 83
Cdd:pfam03250   9 DDIDEDELLKKLSEEELEQLDELLEELDPDNAlLPAGQRQRDQTKKEPTGPFDREKLLHHLEKQALEPKDRE 80
PTZ00121 PTZ00121
MAEBL; Provisional
 87-312 4.95e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 49.75  E-value: 4.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630   87 DESKQVETKTDA---KNGEERGRDASKKALGPRRDSDLGKEPKRGGLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRV 163
Cdd:PTZ00121 1561 EEKKKAEEAKKAeedKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKK 1640

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630  164 RAAVDKKEAgKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDKKREEMK---EVAKKEDDEKVKGERRNtdtRKEGEKMK 240
Cdd:PTZ00121 1641 KEAEEKKKA-EELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKkaaEALKKEAEEAKKAEELK---KKEAEEKK 1716

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 112380630  241 RAggntDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPSEGPAKVEEE 312
Cdd:PTZ00121 1717 KA----EELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEE 1784
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 85-330 8.41e-06

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 48.84  E-value: 8.41e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630    85 SMDESKQVETKTDAKNGEERGRDASKkalgPRRDSDLGKEPKRGGLKksfSRDRDEAGGKsGEKPKEEKIIRG-IDKGRV 163
Cdd:TIGR00927  644 RTGEEGERPTEAEGENGEESGGEAEQ----EGETETKGENESEGEIP---AERKGEQEGE-GEIEAKEADHKGeTEAEEV 715

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630   164 RAAVDKKEAGKDGRGEERAVATKKEEEKKGsdrntglsrDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAG 243
Cdd:TIGR00927  716 EHEGETEAEGTEDEGEIETGEEGEEVEDEG---------EGEAEGKHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAG 786

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630   244 GNTDMKKEDEKVKRGT--------------GNTDTKKDDEKVKKNEPLHE------KEAKDDSKTKTPEKQTPSGPTKPS 303
Cdd:TIGR00927  787 EDGEMKGDEGAEGKVEhegeteagekdeheGQSETQADDTEVKDETGEQElnaenqGEAKQDEKGVDGGGGSDGGDSEEE 866

                          250       260
                   ....*....|....*....|....*..
gi 112380630   304 EGPAKVEEEAAPSIFDEPLERVKNNDP 330
Cdd:TIGR00927  867 EEEEEEEEEEEEEEEEEEEEEEENEEP 893
PTZ00121 PTZ00121
MAEBL; Provisional
 75-311 8.69e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.98  E-value: 8.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630   75 ETKKLMQREMSMDESKQVETKT---DAKNGEERGRDASKKALGPRRDSDLGKEpkrgglKKSFSRDRDEAGGKSGEKPKE 151
Cdd:PTZ00121 1333 AAKKKAEEAKKAAEAAKAEAEAaadEAEAAEEKAEAAEKKKEEAKKKADAAKK------KAEEKKKADEAKKKAEEDKKK 1406

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630  152 EKIIRGIDKGRVRAAVDKKEAGKDGRGEEravATKKEEEKKGSDRNTGLSRDKDKKREEMK--EVAKKEDDEKVKGE--R 227
Cdd:PTZ00121 1407 ADELKKAAAAKKKADEAKKKAEEKKKADE---AKKKAEEAKKADEAKKKAEEAKKAEEAKKkaEEAKKADEAKKKAEeaK 1483

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630  228 RNTDTRKEGEKMKRAGGNTDmKKEDEKVKRgtgnTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPSEGPA 307
Cdd:PTZ00121 1484 KADEAKKKAEEAKKKADEAK-KAAEAKKKA----DEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELK 1558


                  ....
gi 112380630  308 KVEE 311
Cdd:PTZ00121 1559 KAEE 1562
PTZ00121 PTZ00121
MAEBL; Provisional
 81-312 1.55e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.13  E-value: 1.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630   81 QREMSMDESKQVETKTDAKNGEE-RGRDASKKALGPRRDSDlgkEPKRGGLKKSFSRDRDEAGGKSGEKPKEEKIIRGID 159
Cdd:PTZ00121 1182 RKAEEVRKAEELRKAEDARKAEAaRKAEEERKAEEARKAED---AKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFE 1258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630  160 KGRVRAAVDKKEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGE---RRNTDTRKEG 236
Cdd:PTZ00121 1259 EARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEeakKKADAAKKKA 1338

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 112380630  237 EKMKRAggNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEplhEKEAKDDSKTKTPEKQTPSGPTKPSEGPAKVEEE 312
Cdd:PTZ00121 1339 EEAKKA--AEAAKAEAEAAADEAEAAEEKAEAAEKKKEE---AKKKADAAKKKAEEKKKADEAKKKAEEDKKKADE 1409
PTZ00121 PTZ00121
MAEBL; Provisional
 97-311 1.68e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.75  E-value: 1.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630   97 DAKNGEE-RGRDASKKALGPRRDSDLGKEPKrggLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKD 175
Cdd:PTZ00121 1162 DARKAEEaRKAEDAKKAEAARKAEEVRKAEE---LRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKD 1238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630  176 GRGEERA------VATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRA---GGNT 246
Cdd:PTZ00121 1239 AEEAKKAeeernnEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAeeaKKAD 1318

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 112380630  247 DMKKEDEKVKRgTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPSEGPAKVEE 311
Cdd:PTZ00121 1319 EAKKKAEEAKK-KADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADA 1382
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 385-453 2.15e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.01  E-value: 2.15e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 112380630 385 ANKTITSLNLDSNHITGKGILAIFRALLQNNTLTELRFhnQRHICGGKTEMEIAKLLKENTTLLKLGYH 453
Cdd:COG5238  178 QNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWL--KRNPIGDEGAEILAEALKGNKSLTTLDLS 244
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 137-316 7.85e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 39.23  E-value: 7.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630 137 DRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKKGSDRNTG--------LSRDK---- 204
Cdd:NF033838 229 DREKAEEEAKRRADAKLKEAVEKNVATSEQDKPKRRAKRGVLGEPATPDKKENDAKSSDSSVGeetlpspsLKPEKkvae 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630 205 -DKKREEMKEVAKKEDDEkvkgERRN--TDTRKEGEkMKRAGGNTDMKK--------------EDEKVKRGTGNTDTKKD 267
Cdd:NF033838 309 aEKKVEEAKKKAKDQKEE----DRRNypTNTYKTLE-LEIAESDVKVKEaelelvkeeakeprNEEKIKQAKAKVESKKA 383

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 112380630 268 D----EKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPSegPAKVEEEAAPS 316
Cdd:NF033838 384 EatrlEKIKTDRKKAEEEAKRKAAEEDKVKEKPAEQPQPA--PAPQPEKPAPK 434
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 164-312 9.09e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 39.21  E-value: 9.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112380630   164 RAAVDKKEAGKDGRGEERAVAT----KKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKM 239
Cdd:TIGR00927  632 KGDVAEAEHTGERTGEEGERPTeaegENGEESGGEAEQEGETETKGENESEGEIPAERKGEQEGEGEIEAKEADHKGETE 711

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 112380630   240 K---RAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTpSGPTKPSEGPAKVEEE 312
Cdd:TIGR00927  712 AeevEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGKHEVETEGDRKETEHEGET-EAEGKEDEDEGEIQAG 786
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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