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Conserved domains on  [gi|166235163|ref|NP_036477|]
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FMR1-interacting protein NUFIP1 [Homo sapiens]

Protein Classification

nuclear FMR1 interacting protein 1( domain architecture ID 10573452)

nuclear FMR1 interacting protein 1 (NUFIP1) functions in the assembly of the large subunit of the ribosome and in telomere maintenance; contains a C2H2 zinc finger

Gene Symbol:  NUFIP1
Gene Ontology:  GO:0000027|GO:0008270|GO:0003723
PubMed:  15963892|15718139|29700228|35326495

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NUFIP1 pfam10453
Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1); Proteins in this family ...
 216-253 6.02e-15

Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1); Proteins in this family have been implicated in the assembly of the large subunit of the ribosome and in telomere maintenance. Some proteins in this family contain a CCCH zinc finger. This family contains a protein called human fragile X mental retardation-interacting protein 1, which is known to bind RNA and is phosphorylated upon DNA damage.


:

Pssm-ID: 463096 [Multi-domain]  Cd Length: 53  Bit Score: 68.79  E-value: 6.02e-15
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 166235163  216 HWRNMHAPGmKKIKLDTPEEIARWREERRKNYPTLANI 253
Cdd:pfam10453   2 HNKNVKIPG-TSITLETPEDIAKWIEERRKNWPTKINI 38
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 173-194 9.23e-03

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


:

Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 33.68  E-value: 9.23e-03
                          10        20
                  ....*....|....*....|..
gi 166235163  173 HFFCDTCDRGFKNQEKYDKHMS 194
Cdd:pfam12171   1 QFYCVLCDKYFKSENALQNHLK 22
 
Name Accession Description Interval E-value
NUFIP1 pfam10453
Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1); Proteins in this family ...
 216-253 6.02e-15

Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1); Proteins in this family have been implicated in the assembly of the large subunit of the ribosome and in telomere maintenance. Some proteins in this family contain a CCCH zinc finger. This family contains a protein called human fragile X mental retardation-interacting protein 1, which is known to bind RNA and is phosphorylated upon DNA damage.


Pssm-ID: 463096 [Multi-domain]  Cd Length: 53  Bit Score: 68.79  E-value: 6.02e-15
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 166235163  216 HWRNMHAPGmKKIKLDTPEEIARWREERRKNYPTLANI 253
Cdd:pfam10453   2 HNKNVKIPG-TSITLETPEDIAKWIEERRKNWPTKINI 38
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 173-194 9.23e-03

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 33.68  E-value: 9.23e-03
                          10        20
                  ....*....|....*....|..
gi 166235163  173 HFFCDTCDRGFKNQEKYDKHMS 194
Cdd:pfam12171   1 QFYCVLCDKYFKSENALQNHLK 22
 
Name Accession Description Interval E-value
NUFIP1 pfam10453
Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1); Proteins in this family ...
 216-253 6.02e-15

Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1); Proteins in this family have been implicated in the assembly of the large subunit of the ribosome and in telomere maintenance. Some proteins in this family contain a CCCH zinc finger. This family contains a protein called human fragile X mental retardation-interacting protein 1, which is known to bind RNA and is phosphorylated upon DNA damage.


Pssm-ID: 463096 [Multi-domain]  Cd Length: 53  Bit Score: 68.79  E-value: 6.02e-15
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 166235163  216 HWRNMHAPGmKKIKLDTPEEIARWREERRKNYPTLANI 253
Cdd:pfam10453   2 HNKNVKIPG-TSITLETPEDIAKWIEERRKNWPTKINI 38
zf-C2H2_jaz pfam12171
Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, ...
 173-194 9.23e-03

Zinc-finger double-stranded RNA-binding; This domain family is found in archaea and eukaryotes, and is approximately 30 amino acids in length. The mammalian members of this group occur multiple times along the protein, joined by flexible linkers, and are referred to as JAZ - dsRNA-binding ZF protein - zinc-fingers. The JAZ proteins are expressed in all tissues tested and localize in the nucleus, particularly the nucleolus. JAZ preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids rather than DNA. In addition to binding double-stranded RNA, these zinc-fingers are required for nucleolar localization.


Pssm-ID: 432381 [Multi-domain]  Cd Length: 27  Bit Score: 33.68  E-value: 9.23e-03
                          10        20
                  ....*....|....*....|..
gi 166235163  173 HFFCDTCDRGFKNQEKYDKHMS 194
Cdd:pfam12171   1 QFYCVLCDKYFKSENALQNHLK 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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