NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|6912574|ref|NP_036520|]
View 

biogenesis of lysosome-related organelles complex 1 subunit 6 isoform 2 [Homo sapiens]

Protein Classification

snapin/pallidin family protein( domain architecture ID 10631502)

snapin/pallidin family protein is a component of the BLOC-1 complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Snapin_Pallidin pfam14712
Snapin/Pallidin; This family of proteins includes Snapin, this protein is associated with the ...
 50-140 1.10e-22

Snapin/Pallidin; This family of proteins includes Snapin, this protein is associated with the SNARE complex, which mediates synaptic vesicle docking and fusion. It also includes the yeast snapin-like protein SNN1, which is a part of a complex involved in endosomal cargo sorting. The family also includes pallidin, a component of a complex involved in biogenesis of lysosome-related organelles.


:

Pssm-ID: 464275  Cd Length: 90  Bit Score: 86.47  E-value: 1.10e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912574     50 EQLAEGLLSHYLPDLQRSKQALQELTQNQVVLLDTLEQEISKFKEChSMLDINALFAEAKHYHAKLVNIRKEMLMLHEKT 129
Cdd:pfam14712   1 DALAEGLLNLLEPVLDELDEKLQELRQSQEELLEQIDRLNEELDEL-LELQDNEMMPDLKPYVKKLVNIKKRMSSLNERL 79

                          90
                  ....*....|.
gi 6912574    130 SKLKKRALKLQ 140
Cdd:pfam14712  80 QKLQKRALKLQ 90
 
Name Accession Description Interval E-value
Snapin_Pallidin pfam14712
Snapin/Pallidin; This family of proteins includes Snapin, this protein is associated with the ...
 50-140 1.10e-22

Snapin/Pallidin; This family of proteins includes Snapin, this protein is associated with the SNARE complex, which mediates synaptic vesicle docking and fusion. It also includes the yeast snapin-like protein SNN1, which is a part of a complex involved in endosomal cargo sorting. The family also includes pallidin, a component of a complex involved in biogenesis of lysosome-related organelles.


Pssm-ID: 464275  Cd Length: 90  Bit Score: 86.47  E-value: 1.10e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912574     50 EQLAEGLLSHYLPDLQRSKQALQELTQNQVVLLDTLEQEISKFKEChSMLDINALFAEAKHYHAKLVNIRKEMLMLHEKT 129
Cdd:pfam14712   1 DALAEGLLNLLEPVLDELDEKLQELRQSQEELLEQIDRLNEELDEL-LELQDNEMMPDLKPYVKKLVNIKKRMSSLNERL 79

                          90
                  ....*....|.
gi 6912574    130 SKLKKRALKLQ 140
Cdd:pfam14712  80 QKLQKRALKLQ 90
 
Name Accession Description Interval E-value
Snapin_Pallidin pfam14712
Snapin/Pallidin; This family of proteins includes Snapin, this protein is associated with the ...
 50-140 1.10e-22

Snapin/Pallidin; This family of proteins includes Snapin, this protein is associated with the SNARE complex, which mediates synaptic vesicle docking and fusion. It also includes the yeast snapin-like protein SNN1, which is a part of a complex involved in endosomal cargo sorting. The family also includes pallidin, a component of a complex involved in biogenesis of lysosome-related organelles.


Pssm-ID: 464275  Cd Length: 90  Bit Score: 86.47  E-value: 1.10e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912574     50 EQLAEGLLSHYLPDLQRSKQALQELTQNQVVLLDTLEQEISKFKEChSMLDINALFAEAKHYHAKLVNIRKEMLMLHEKT 129
Cdd:pfam14712   1 DALAEGLLNLLEPVLDELDEKLQELRQSQEELLEQIDRLNEELDEL-LELQDNEMMPDLKPYVKKLVNIKKRMSSLNERL 79

                          90
                  ....*....|.
gi 6912574    130 SKLKKRALKLQ 140
Cdd:pfam14712  80 QKLQKRALKLQ 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH