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Conserved domains on  [gi|185134818|ref|NP_036756|]
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pyruvate kinase PKLR [Rattus norvegicus]

Protein Classification

pyruvate kinase( domain architecture ID 10084586)

pyruvate kinase catalyzes the phosphorylation of pyruvate to form phosphoenolpyruvate and functions in regulating glycolysis

CATH:  2.40.33.10|3.20.20.60|3.40.1380.20
EC:  2.7.1.40
Gene Ontology:  GO:0004743|GO:0006096|GO:0005524|GO:0030955|GO:0000287
PubMed:  31342570
SCOP:  4003255|4002474|4000500

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 54-542 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


:

Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 786.12  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  54 ARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESFAtsplsyRPVAIALDTKGPEIRT 133
Cdd:cd00288    1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG------GPVAIALDTKGPEIRT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 134 GVLQGGpeSEVEIVKGSQVLVTVDPKfQTRGDAKTVWVDYHNITRVVAVGGRIYIDDGLISLVVQKIGPE-GLVTEVEHG 212
Cdd:cd00288   75 GLFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNG 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 213 GILGSRKGVNLPNTEVDLPGLSEQDLLDLRFGVQHNVDIIFASFVRKASDVLAVRDALGPEGQNIKIISKIENHEGVKKF 292
Cdd:cd00288  152 GVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNF 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 293 DEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIM 372
Cdd:cd00288  232 DEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 373 LSGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQL 452
Cdd:cd00288  312 LSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARL 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 453 LSQYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREPPEaIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSG 532
Cdd:cd00288  392 VSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKP-GWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSG 470

                        490
                 ....*....|
gi 185134818 533 YTNIMRVLSV 542
Cdd:cd00288  471 STNTMRILTV 480
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 54-542 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 786.12  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  54 ARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESFAtsplsyRPVAIALDTKGPEIRT 133
Cdd:cd00288    1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG------GPVAIALDTKGPEIRT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 134 GVLQGGpeSEVEIVKGSQVLVTVDPKfQTRGDAKTVWVDYHNITRVVAVGGRIYIDDGLISLVVQKIGPE-GLVTEVEHG 212
Cdd:cd00288   75 GLFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNG 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 213 GILGSRKGVNLPNTEVDLPGLSEQDLLDLRFGVQHNVDIIFASFVRKASDVLAVRDALGPEGQNIKIISKIENHEGVKKF 292
Cdd:cd00288  152 GVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNF 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 293 DEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIM 372
Cdd:cd00288  232 DEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 373 LSGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQL 452
Cdd:cd00288  312 LSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARL 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 453 LSQYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREPPEaIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSG 532
Cdd:cd00288  392 VSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKP-GWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSG 470

                        490
                 ....*....|
gi 185134818 533 YTNIMRVLSV 542
Cdd:cd00288  471 STNTMRILTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 55-539 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 661.28  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818   55 RSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESFAtsplsyRPVAIALDTKGPEIRTG 134
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLG------RPVAILLDTKGPEIRTG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  135 VLQGGPeseVEIVKGSQVLVTVDPKFQTrGDAKTVWVDYHNITRVVAVGGRIYIDDGLISLVVQKIGPEGLVTEVEHGGI 214
Cdd:TIGR01064  75 EIKGGE---VKLKKGDKVIITTDDIKGE-GDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  215 LGSRKGVNLPNTEVDLPGLSEQDLLDLRFGVQHNVDIIFASFVRKASDVLAVRDALGPEG-QNIKIISKIENHEGVKKFD 293
Cdd:TIGR01064 151 LKSKKGVNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNID 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  294 EILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIML 373
Cdd:TIGR01064 231 EIAEASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVML 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  374 SGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLL 453
Cdd:TIGR01064 311 SGETAKGKYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLL 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  454 SQYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREppeaiWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTG-WRPGSG 532
Cdd:TIGR01064 391 SKYRPNAPIIAVTPNERVARQLALYWGVFPFLVDE-----EPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEG 465


                  ....*..
gi 185134818  533 YTNIMRV 539
Cdd:TIGR01064 466 GTNTIRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 55-542 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 624.36  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  55 RSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESFAtsplsyRPVAIALDTKGPEIRTG 134
Cdd:COG0469    3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELG------RPVAILLDLQGPKIRTG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 135 VLQGGPeseVEIVKGSQVLVTVDPkfqTRGDAKTVWVDYHNITRVVAVGGRIYIDDGLISLVVQKIGPEGLVTEVEHGGI 214
Cdd:COG0469   77 KFKEGP---VELKKGDTFTLTTDD---VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 215 LGSRKGVNLPNTEVDLPGLSEQDLLDLRFGVQHNVDIIFASFVRKASDVLAVRDALGPEGQNIKIISKIENHEGVKKFDE 294
Cdd:COG0469  151 LSSRKGVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDE 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 295 ILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIMLS 374
Cdd:COG0469  231 IIEASDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLS 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 375 GETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRRAAPlsRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLS 454
Cdd:COG0469  311 GETAVGKYPVEAVETMARIAEEAEKSLDYRRILDRLRDEPE--RTITDAIARAAVELAEDLGAKAIVAFTESGSTARRIS 388

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 455 QYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREppeaiwADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPG-SGY 533
Cdd:COG0469  389 RYRPKVPILALTPNERTARRLALVWGVYPVLVDD------VESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGvPGT 462


                 ....*....
gi 185134818 534 TNIMRVLSV 542
Cdd:COG0469  463 TNTLKVHRV 471
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 54-407 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 595.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818   54 ARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESFATSplsyrpVAIALDTKGPEIRT 133
Cdd:pfam00224   1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGT------VAIALDTKGPEIRT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  134 GVLQGGPeSEVEIVKGSQVLVTVDPKFQTRGDAKTVWVDYHNITRVVAVGGRIYIDDGLISLVVQKIGPE-GLVTEVEHG 212
Cdd:pfam00224  75 GNTKDGK-KDIELKAGDEMIVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDkTLVVEVLNG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  213 GILGSRKGVNLPNTEVDLPGLSEQDLLDLRFGVQHNVDIIFASFVRKASDVLAVRDALGPEGQNIKIISKIENHEGVKKF 292
Cdd:pfam00224 154 GVIGSRKGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNF 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  293 DEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIM 372
Cdd:pfam00224 234 DEILEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 313

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 185134818  373 LSGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLF 407
Cdd:pfam00224 314 LSGETAKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
PRK05826 PRK05826
pyruvate kinase; Provisional
 55-526 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 525.10  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  55 RSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESFAtsplsyRPVAIALDTKGPEIRTG 134
Cdd:PRK05826   4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLG------RPVAILLDLKGPKIRVG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 135 VLQGGPeseVEIVKGSQVLVTVDPKFQtrGDAKTVWVDYHNITRVVAVGGRIYIDDGLISLVVQKIGPEGLVTEVEHGGI 214
Cdd:PRK05826  78 KFKEGK---ITLKTGDKFTLDTDQKEE--GDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGP 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 215 LGSRKGVNLPNTEVDLPGLSEQDLLDLRFGVQHNVDIIFASFVRKASDVLAVRDAL---GpeGQNIKIISKIENHEGVKK 291
Cdd:PRK05826 153 LSNNKGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLreaG--CPHAKIIAKIERAEAVDN 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 292 FDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCI 371
Cdd:PRK05826 231 IDEIIEASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAV 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 372 MLSGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRRAaplSRDPTEVTAIGAVEASFK-CCAAAIIVLTKTGRSA 450
Cdd:PRK05826 311 MLSGETAAGKYPVEAVEAMARICKGAEKEFSINLSKHRLDRQ---FDRIDEAIAMSAMYAANHlKGVKAIVALTESGRTA 387

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 185134818 451 QLLSQYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREP-PEAIWADDVdrrvqfgIESGKLRGFLRVGDLVIVVTG 526
Cdd:PRK05826 388 RLISRFRPGAPIFAVTRDEKTQRRLALYRGVYPVLFDSAaDTDDAAEEA-------LRLLLEKGLVESGDLVVVTSG 457
 
Name Accession Description Interval E-value
Pyruvate_Kinase cd00288
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ...
 54-542 0e+00

Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.


Pssm-ID: 238178 [Multi-domain]  Cd Length: 480  Bit Score: 786.12  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  54 ARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESFAtsplsyRPVAIALDTKGPEIRT 133
Cdd:cd00288    1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTG------GPVAIALDTKGPEIRT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 134 GVLQGGpeSEVEIVKGSQVLVTVDPKfQTRGDAKTVWVDYHNITRVVAVGGRIYIDDGLISLVVQKIGPE-GLVTEVEHG 212
Cdd:cd00288   75 GLFKGG--KDISLKAGDKFLVTTDPA-AKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNG 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 213 GILGSRKGVNLPNTEVDLPGLSEQDLLDLRFGVQHNVDIIFASFVRKASDVLAVRDALGPEGQNIKIISKIENHEGVKKF 292
Cdd:cd00288  152 GVLGSRKGVNLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNF 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 293 DEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIM 372
Cdd:cd00288  232 DEILEASDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 373 LSGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQL 452
Cdd:cd00288  312 LSGETAKGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPRPTSTTEAVAMSAVRAAFELGAKAIVVLTTSGRTARL 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 453 LSQYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREPPEaIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSG 532
Cdd:cd00288  392 VSKYRPNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPKP-GWQEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPVGSG 470

                        490
                 ....*....|
gi 185134818 533 YTNIMRVLSV 542
Cdd:cd00288  471 STNTMRILTV 480
pyruv_kin TIGR01064
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ...
 55-539 0e+00

pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 273424 [Multi-domain]  Cd Length: 472  Bit Score: 661.28  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818   55 RSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESFAtsplsyRPVAIALDTKGPEIRTG 134
Cdd:TIGR01064   1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLG------RPVAILLDTKGPEIRTG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  135 VLQGGPeseVEIVKGSQVLVTVDPKFQTrGDAKTVWVDYHNITRVVAVGGRIYIDDGLISLVVQKIGPEGLVTEVEHGGI 214
Cdd:TIGR01064  75 EIKGGE---VKLKKGDKVIITTDDIKGE-GDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  215 LGSRKGVNLPNTEVDLPGLSEQDLLDLRFGVQHNVDIIFASFVRKASDVLAVRDALGPEG-QNIKIISKIENHEGVKKFD 293
Cdd:TIGR01064 151 LKSKKGVNLPGADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDNID 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  294 EILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIML 373
Cdd:TIGR01064 231 EIAEASDGIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVML 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  374 SGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLL 453
Cdd:TIGR01064 311 SGETAKGKYPVEAVQMMAKIAKEAEKALAYLTNFNDRKNSDPKPSTITEAIALSAVEAAEKLDAKAIVVLTESGRTARLL 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  454 SQYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREppeaiWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTG-WRPGSG 532
Cdd:TIGR01064 391 SKYRPNAPIIAVTPNERVARQLALYWGVFPFLVDE-----EPSDTDARVNKALELLKEKGIVKKGDLVVVIQGgPIGGEG 465


                  ....*..
gi 185134818  533 YTNIMRV 539
Cdd:TIGR01064 466 GTNTIRV 472
PykF COG0469
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ...
 55-542 0e+00

Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 440237 [Multi-domain]  Cd Length: 471  Bit Score: 624.36  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  55 RSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESFAtsplsyRPVAIALDTKGPEIRTG 134
Cdd:COG0469    3 RRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELG------RPVAILLDLQGPKIRTG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 135 VLQGGPeseVEIVKGSQVLVTVDPkfqTRGDAKTVWVDYHNITRVVAVGGRIYIDDGLISLVVQKIGPEGLVTEVEHGGI 214
Cdd:COG0469   77 KFKEGP---VELKKGDTFTLTTDD---VEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 215 LGSRKGVNLPNTEVDLPGLSEQDLLDLRFGVQHNVDIIFASFVRKASDVLAVRDALGPEGQNIKIISKIENHEGVKKFDE 294
Cdd:COG0469  151 LSSRKGVNLPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAVENLDE 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 295 ILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIMLS 374
Cdd:COG0469  231 IIEASDGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLS 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 375 GETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRRAAPlsRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLS 454
Cdd:COG0469  311 GETAVGKYPVEAVETMARIAEEAEKSLDYRRILDRLRDEPE--RTITDAIARAAVELAEDLGAKAIVAFTESGSTARRIS 388

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 455 QYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREppeaiwADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPG-SGY 533
Cdd:COG0469  389 RYRPKVPILALTPNERTARRLALVWGVYPVLVDD------VESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGvPGT 462


                 ....*....
gi 185134818 534 TNIMRVLSV 542
Cdd:COG0469  463 TNTLKVHRV 471
PK pfam00224
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ...
 54-407 0e+00

Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.


Pssm-ID: 395168 [Multi-domain]  Cd Length: 348  Bit Score: 595.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818   54 ARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESFATSplsyrpVAIALDTKGPEIRT 133
Cdd:pfam00224   1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGT------VAIALDTKGPEIRT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  134 GVLQGGPeSEVEIVKGSQVLVTVDPKFQTRGDAKTVWVDYHNITRVVAVGGRIYIDDGLISLVVQKIGPE-GLVTEVEHG 212
Cdd:pfam00224  75 GNTKDGK-KDIELKAGDEMIVSTDAKYKGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDkTLVVEVLNG 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  213 GILGSRKGVNLPNTEVDLPGLSEQDLLDLRFGVQHNVDIIFASFVRKASDVLAVRDALGPEGQNIKIISKIENHEGVKKF 292
Cdd:pfam00224 154 GVIGSRKGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGVNNF 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  293 DEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIM 372
Cdd:pfam00224 234 DEILEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVM 313

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 185134818  373 LSGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLF 407
Cdd:pfam00224 314 LSGETAKGNYPVEAVRMMHEICLEAEKALPHRNLF 348
PRK05826 PRK05826
pyruvate kinase; Provisional
 55-526 0e+00

pyruvate kinase; Provisional


Pssm-ID: 235619 [Multi-domain]  Cd Length: 465  Bit Score: 525.10  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  55 RSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESFAtsplsyRPVAIALDTKGPEIRTG 134
Cdd:PRK05826   4 RRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLG------RPVAILLDLKGPKIRVG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 135 VLQGGPeseVEIVKGSQVLVTVDPKFQtrGDAKTVWVDYHNITRVVAVGGRIYIDDGLISLVVQKIGPEGLVTEVEHGGI 214
Cdd:PRK05826  78 KFKEGK---ITLKTGDKFTLDTDQKEE--GDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGP 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 215 LGSRKGVNLPNTEVDLPGLSEQDLLDLRFGVQHNVDIIFASFVRKASDVLAVRDAL---GpeGQNIKIISKIENHEGVKK 291
Cdd:PRK05826 153 LSNNKGINIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLreaG--CPHAKIIAKIERAEAVDN 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 292 FDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCI 371
Cdd:PRK05826 231 IDEIIEASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAV 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 372 MLSGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRRAaplSRDPTEVTAIGAVEASFK-CCAAAIIVLTKTGRSA 450
Cdd:PRK05826 311 MLSGETAAGKYPVEAVEAMARICKGAEKEFSINLSKHRLDRQ---FDRIDEAIAMSAMYAANHlKGVKAIVALTESGRTA 387

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 185134818 451 QLLSQYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREP-PEAIWADDVdrrvqfgIESGKLRGFLRVGDLVIVVTG 526
Cdd:PRK05826 388 RLISRFRPGAPIFAVTRDEKTQRRLALYRGVYPVLFDSAaDTDDAAEEA-------LRLLLEKGLVESGDLVVVTSG 457
PLN02461 PLN02461
Probable pyruvate kinase
 57-524 0e+00

Probable pyruvate kinase


Pssm-ID: 215255 [Multi-domain]  Cd Length: 511  Bit Score: 521.46  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  57 TSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESfaTSPLSyrpvAIALDTKGPEIRTGVL 136
Cdd:PLN02461  23 TKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMAN--TGILC----AVMLDTKGPEIRTGFL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 137 Q-GGPeseVEIVKGSQVLVTVDpkFQTRGDAKTVWVDYHNITRVVAVGGRIYIDDGLISLVVQKIGPE-GLVT-EVEHGG 213
Cdd:PLN02461  97 KdGKP---VQLKQGQEITITTD--YSIKGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLSCDVEaGTVRcRCENSA 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 214 ILGSRKGVNLPNTEVDLPGLSEQDLLD-LRFGVQHNVDIIFASFVRKASDVLAVRDALGPEGQNIKIISKIENHEGVKKF 292
Cdd:PLN02461 172 MLGERKNVNLPGVVVDLPTLTEKDKEDiLQWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLISKVENQEGLDNF 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 293 DEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIM 372
Cdd:PLN02461 252 DDILAESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVM 331

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 373 LSGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQL 452
Cdd:PLN02461 332 LSGETAAGAYPELAVKTMARICREAEASLDYGALFKEIMRSAPLPMSPLESLASSAVRTANKVKASLIVVLTRGGTTARL 411

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 453 LSQYRPRAAVIAV------TRSAQ-------AARQVHLSRGVFPLLYREPPEAIWADDVDRRVQFGIESGKLRGFLRVGD 519
Cdd:PLN02461 412 VAKYRPAVPILSVvvpeitTDSFDwscsdeaPARHSLIYRGLIPVLAEGSAKATDSESTEEILEAAIEHAKKKGLCKPGD 491


                 ....*
gi 185134818 520 LVIVV 524
Cdd:PLN02461 492 SVVAL 496
PRK09206 PRK09206
pyruvate kinase PykF;
55-539 3.17e-172

pyruvate kinase PykF;


Pssm-ID: 181699 [Multi-domain]  Cd Length: 470  Bit Score: 494.96  E-value: 3.17e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  55 RSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESfatsplSYRPVAIALDTKGPEIRTG 134
Cdd:PRK09206   2 KKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSK------TGKKAAILLDTKGPEIRTM 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 135 VLQGGpeSEVEIVKGSQVLVTVDPKFQtrGDAKTVWVDYHNITRVVAVGGRIYIDDGLISLVVQKIGPEGLVTEVEHGGI 214
Cdd:PRK09206  76 KLEGG--NDVSLKAGQTFTFTTDKSVV--GNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGD 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 215 LGSRKGVNLPNTEVDLPGLSEQDLLDLRFGVQHNVDIIFASFVRKASDVLAVRDALGPE-GQNIKIISKIENHEGVKKFD 293
Cdd:PRK09206 152 LGENKGVNLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREHLKAHgGENIQIISKIENQEGLNNFD 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 294 EILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIML 373
Cdd:PRK09206 232 EILEASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVML 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 374 SGETAKGSFPVEAVMMQHAIAREAEAAVYHRqlFEELRRAAPLsrDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLL 453
Cdd:PRK09206 312 SGESAKGKYPLEAVSIMATICERTDRVMNSR--LESNNDNRKL--RITEAVCRGAVETAEKLDAPLIVVATQGGKSARSV 387

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 454 SQYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREPpeaiwaDDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGY 533
Cdd:PRK09206 388 RKYFPDATILALTTNEKTARQLVLSKGVVPQLVKEI------ASTDDFYRLGKELALQSGLAQKGDVVVMVSGALVPSGT 461


                 ....*.
gi 185134818 534 TNIMRV 539
Cdd:PRK09206 462 TNTASV 467
PRK06354 PRK06354
pyruvate kinase; Provisional
 49-539 1.40e-167

pyruvate kinase; Provisional


Pssm-ID: 235784 [Multi-domain]  Cd Length: 590  Bit Score: 487.51  E-value: 1.40e-167
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  49 SQPVAARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAteSFATSplsyRPVAIALDTKG 128
Cdd:PRK06354   2 SLRDLMRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREA--SKKLG----KTVGILQDLQG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 129 PEIRTGVLQGGPeseVEIVKGSQVLVTVDPKfqtRGDAKTVWVDYHNITRVVAVGGRIYIDDGLISLVVQKIGPEG--LV 206
Cdd:PRK06354  76 PKIRLGRFEDGP---IELKTGDEFILTSREV---LGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKADgeLH 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 207 TEVEHGGILGSRKGVNLPNTEVDLPGLSEQDLLDLRFGVQHNVDIIFASFVRKASDVLAVRDALGPE-GQNIKIISKIEN 285
Cdd:PRK06354 150 CKVLVGGVLSNKKGVNFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELIEEHnGKHIPIIAKIEK 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 286 HEGVKKFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVL 365
Cdd:PRK06354 230 QEAIDNIDAILELCDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAIL 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 366 DGADCIMLSGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRRAaplsrDPTEVTAIG-AV-EASFKCCAAAIIVL 443
Cdd:PRK06354 310 DGTDAVMLSNETAAGDYPVEAVQTMATIAVRIEKDLPYRDILSKRPEF-----TTTITNAISqAVsHIALQLDAAAIVTL 384

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 444 TKTGRSAQLLSQYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREPPEAiwaddvDRRVQFGIESGKLRGFLRVGDLVIV 523
Cdd:PRK06354 385 TKSGATARNVSKYRPKTPILAVTPNESVARRLQLVWGVTPLLVLDAPST------DETFDAAINVAQESGLLKQGDLVVI 458

                        490
                 ....*....|....*..
gi 185134818 524 VTGWRPG-SGYTNIMRV 539
Cdd:PRK06354 459 TAGTLVGeSGSTDLMKV 475
PTZ00300 PTZ00300
pyruvate kinase; Provisional
 81-543 1.21e-166

pyruvate kinase; Provisional


Pssm-ID: 140321 [Multi-domain]  Cd Length: 454  Bit Score: 480.32  E-value: 1.21e-166
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  81 MNIARLNFSHGSHEYHAESIANIREATESFATSplsyrpVAIALDTKGPEIRTGVLQGGpesEVEIVKGSQVLVTVDPKF 160
Cdd:PTZ00300   1 MSVARMNFSHGSHEYHQTTINNVRQAAAELGVN------IAIALDTKGPEIRTGLFVGG---EAVMERGATCYVTTDPAF 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 161 QTRGDAKTVWVDYHNITRVVAVGGRIYIDDGLISLVVQKIGPE-GLVTEVEHGGILGSRKGVNLPNTEVDLPGLSEQDLL 239
Cdd:PTZ00300  72 ADKGTKDKFYIDYQNLSKVVRPGGYIYIDDGILILHVQSHEDEqTLKCTVTNAHTISDRRGVNLPGCDVDLPAVSAKDCA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 240 DLRFGVQHNVDIIFASFVRKASDVLAVRDALGPEGQNIKIISKIENHEGVKKFDEILEVSDGIMVARGDLGIEIPAEKVF 319
Cdd:PTZ00300 152 DLQFGVEQGVDMIFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGVQNIDSIIEESDGIMVARGDLGVEIPAEKVV 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 320 LAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIMLSGETAKGSFPVEAVMMQHAIAREAEA 399
Cdd:PTZ00300 232 VAQKILISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQS 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 400 AVYHRQLFEELRRAAPLSRDPTEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSQYRPRAAVIAVTRSAQAARQVHLSR 479
Cdd:PTZ00300 312 AVNEYVFFNSIKKLQPIPMSAEEAVCSSAVNSVYETKAKALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQ 391

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 185134818 480 GVFPLLYrePPEAIWADD-VDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSVS 543
Cdd:PTZ00300 392 GVESVFF--DAERLGHDEgKEQRVAMGVGFAKSKGYVQSGDLMVVVHADHKVKGYANQTRIILVS 454
PTZ00066 PTZ00066
pyruvate kinase; Provisional
 36-542 2.11e-164

pyruvate kinase; Provisional


Pssm-ID: 173361 [Multi-domain]  Cd Length: 513  Bit Score: 476.95  E-value: 2.11e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  36 DTFLEHLCLLDIDSqpvaaRSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESfatspl 115
Cdd:PTZ00066  24 DKILEPISDNDLRQ-----KKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVREAAKA------ 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 116 syRP---VAIALDTKGPEIRTGVLQGGpeSEVEIVKGSQVLVTVDPKFQtrGDAKTVWVDYHNITRVVAVGGRIYIDDGL 192
Cdd:PTZ00066  93 --RPnanLGILLDTKGPEIRTGFLKNH--KPITLKEGQTLKITTDYTFL--GDETCISCSYKKLPQSVKVGNIILIADGS 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 193 ISLVVQKIGPEGLVTEVEHGGILGSRKGVNLPNTEVDLPGLSEQDLLD-LRFGVQHNVDIIFASFVRKASDVLAVRDALG 271
Cdd:PTZ00066 167 LSCKVLEVHDDYIITKVLNNATIGERKNMNLPGVKVELPVIGEKDKNDiLNFAIPMGCDFIALSFVQSADDVRLCRQLLG 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 272 PEGQNIKIISKIENHEGVKKFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKAR 351
Cdd:PTZ00066 247 ERGRHIKIIPKIENIEGLINFDEILAESDGIMVARGDLGMEIPPEKVFLAQKMMISKCNVAGKPVITATQMLESMIKNPR 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 352 PTRAETSDVANAVLDGADCIMLSGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEA 431
Cdd:PTZ00066 327 PTRAESTDVANAVLDGTDCVMLSGETANGKFPVEAVNIMAKICFEAETCIDYRVLYHAIHLAVPTPVSVQEAVARSAVET 406

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 432 SFKCCAAAIIVLTKTGRSAQLLSQYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREppeaiwADDVDRRVQFGIESGKL 511
Cdd:PTZ00066 407 AEDINAKLIIALTETGNTARLISKYRPSCTILALSASPSVVKSLSVARGVTTYVVNS------FQGTDVVIRNAIALAKE 480

                        490       500       510
                 ....*....|....*....|....*....|..
gi 185134818 512 RGFLRVGDLVIVVTGWRPG-SGYTNIMRVLSV 542
Cdd:PTZ00066 481 RGLVESGDSAIAVHGVKEEvAGSSNLMKVVKI 512
PRK06247 PRK06247
pyruvate kinase; Provisional
 54-543 2.15e-134

pyruvate kinase; Provisional


Pssm-ID: 180487 [Multi-domain]  Cd Length: 476  Bit Score: 398.92  E-value: 2.15e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  54 ARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESFAtsplsyRPVAIALDTKGPEIRT 133
Cdd:PRK06247   4 NRRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETG------RPIGILADLQGPKLRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 134 GVLQGGPeseVEIVKGSQVLVTVDPkfqTRGDAKTVWVDYHNITRVVAVGGRIYIDDGLISLVVQKIGPEGLVTEVEHGG 213
Cdd:PRK06247  78 GRFADGK---VQLANGQTFRLDVDD---APGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGG 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 214 ILGSRKGVNLPNTEVDLPGLSEQDLLDLRFGVQHNVDIIFASFVRKASDVLAVRDAlgpEGQNIKIISKIENHEGVKKFD 293
Cdd:PRK06247 152 PVSDRKGVSLPGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKI---IGGRVPVMAKIEKPQAIDRLE 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 294 EILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIML 373
Cdd:PRK06247 229 AIVEASDAIMVARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVML 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 374 SGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEelrraapLSRDPTEVTAIGAVEASFKCCA-----AAIIVLTKTGR 448
Cdd:PRK06247 309 SAETASGKYPVEAVRTMARIIRQVERDPTYPPLIH-------AQRPQPEATKRDAISYAARDIAerldlAALVAYTSSGD 381

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 449 SAQLLSQYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREppeaiwADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWR 528
Cdd:PRK06247 382 TALRAARERPPLPILALTPNPETARRLALTWGVHCVVVDD------ARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVP 455

                        490
                 ....*....|....*.
gi 185134818 529 PG-SGYTNIMRVLSVS 543
Cdd:PRK06247 456 PGtPGSTNMLRIAYIG 471
PLN02765 PLN02765
pyruvate kinase
 57-523 8.13e-110

pyruvate kinase


Pssm-ID: 215409 [Multi-domain]  Cd Length: 526  Bit Score: 337.41  E-value: 8.13e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  57 TSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESfatsplSYRPVAIALDTKGPEIrtGVL 136
Cdd:PLN02765  30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKN------TKKLCAVMLDTVGPEL--QVI 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 137 QGgPESEVEIVKGSQVLVTVDpkfQTRG-DAKTVWVDYHNITRVVAVGGRIYIDDGLIS--------LVVQKIGPEGLVT 207
Cdd:PLN02765 102 NK-TEKPISLKAGNTVTLTPD---QSKEaSSEVLPINFPGLAKAVKPGDTIFVGQYLFTgsettsvwLEVDEVKGDDVVC 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 208 EVEHGGIL-GSRKGVNLPNTEVDLPGLSEQDLLDLR-FGVQHNVDIIFASFVRKASDVLAVRDALGPEG-QNIKIISKIE 284
Cdd:PLN02765 178 TVKNSATLaGSLFTLHVSQVRIDLPTLSEKDKEVIStWGVPNKIDFLSLSYTRHAEDVREAREFLSSLGlSQTQIFAKIE 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 285 NHEGVKKFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVcATQMLESMITKARPTRAETSDVANAV 364
Cdd:PLN02765 258 NVEGLTHFDEILQEADGIILSRGNLGIDLPPEKVFLFQKAALYKCNMAGKPAV-VTRVVDSMTDNLRPTRAEATDVANAV 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 365 LDGADCIMLSGETAKGSFPVEAVMMQHAIAREAEaAVYHRQLFeeLRRAAPLSRDP---TEVTAIGAVEASFKCCAAAII 441
Cdd:PLN02765 337 LDGADAILLGAETLRGLYPVETISTVGRICAEAE-KVFNQDLY--FKKTVKYVGEPmshLESIASSAVRAAIKVKASVII 413

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 442 VLTKTGRSAQLLSQYRPRAAVIAVT-------------RSAQAARQVHLSRGVFPLLY--REPPEAIWADDvDRRVQFGI 506
Cdd:PLN02765 414 VFTSSGRAARLIAKYRPTMPVLSVViprlktnqlkwsfTGAFQARQCLIVRGLFPMLAdpRHSAESTSATN-ESVLKVAL 492

                        490
                 ....*....|....*..
gi 185134818 507 ESGKLRGFLRVGDLVIV 523
Cdd:PLN02765 493 DHGKAAGVIKSHDRVVV 509
PLN02623 PLN02623
pyruvate kinase
 49-542 4.46e-97

pyruvate kinase


Pssm-ID: 215334 [Multi-domain]  Cd Length: 581  Bit Score: 306.08  E-value: 4.46e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  49 SQPVAARSTSIIATIGPASRSvdrlKEMI----KAGMNIARLNFSHGSHEYHAESIANIREATESFATSPlsyrpVAIAL 124
Cdd:PLN02623 104 SKPSVRRKTKIVCTIGPSTNT----REMIwklaEAGMNVARLNMSHGDHASHQKVIDLVKEYNAQSKDNV-----IAIML 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 125 DTKGPEIRTG------VLQGGPESEVEIVKGSqvlvtvdpkfqtrGDAKTVWVDYHNITRVVAVGGRIYIDDGLISLVVQ 198
Cdd:PLN02623 175 DTKGPEVRSGdlpqpiMLEEGQEFTFTIKRGV-------------STEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVK 241

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 199 KIGPEGLVTEVEHGGILGSRKGVNLPNTEVDLPGLSEQDLLDLRFGVQHNVDIIFASFVRKASDVLAVRDALGPEGQNIK 278
Cdd:PLN02623 242 SKTSDSVKCEVVDGGELKSRRHLNVRGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNADIH 321

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 279 IISKIENHEGVKKFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETS 358
Cdd:PLN02623 322 VIVKIESADSIPNLHSIITASDGAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVS 401

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 359 DVANAVLDGADCIMLSGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRRAAplsrdPTEVTAIGAVEASF--KCC 436
Cdd:PLN02623 402 DIAIAVREGADAVMLSGETAHGKFPLKAVKVMHTVALRTEATLPEGTTPPNLGQAF-----KNHMSEMFAFHATMmaNTL 476

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 437 AAAIIVLTKTGRSAQLLSQYRPRAAVIAVTRSAQAARQVHLSRGVFPlLYREppeaiWADDVDRRVQFGIESGKLRGFLR 516
Cdd:PLN02623 477 GTSIIVFTRTGFMAILLSHYRPSGTIFAFTNEKRIQQRLALYQGVCP-IYMQ-----FSDDAEETFARALSLLLNKGMVK 550

                        490       500       510
                 ....*....|....*....|....*....|.
gi 185134818 517 VGDLVIVVTG-----WRpgSGYTNIMRVLSV 542
Cdd:PLN02623 551 EGEEVALVQSgrqpiWR--SESTHHIQVRKV 579
PRK06739 PRK06739
pyruvate kinase; Validated
 60-398 1.53e-92

pyruvate kinase; Validated


Pssm-ID: 180676 [Multi-domain]  Cd Length: 352  Bit Score: 286.84  E-value: 1.53e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  60 IATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESfatsplsyrpVAIALDTKGPEIRTGVLQGg 139
Cdd:PRK06739   6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKSLDDS----------IKILGDVQGPKIRLGEIKG- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 140 peSEVEIVKGSQVLVTVDPkfqTRGDAKTVWVDYHNITRVVAVGGRIYIDDGLISLVVQKIGPEGLVTEVEHGGILGSRK 219
Cdd:PRK06739  75 --EQITLQAGDSFILHTQP---VTGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHK 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 220 GVNLPNTEVDLPGLSEQDLLDLRFGVQHNVDIIFASFVRKASDVLAVRDALGPEGQNI-KIISKIENHEGVKKFDEILEV 298
Cdd:PRK06739 150 GVNLPGAIVRLPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSpNLIAKIETMEAIENFQDICKE 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 299 SDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIMLSGETA 378
Cdd:PRK06739 230 ADGIMIARGDLGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESA 309

                        330       340
                 ....*....|....*....|
gi 185134818 379 KGSFPVEAVMMQHAIAREAE 398
Cdd:PRK06739 310 SGEHPIESVSTLRLVSEFAE 329
PLN02762 PLN02762
pyruvate kinase complex alpha subunit
 54-536 4.21e-88

pyruvate kinase complex alpha subunit


Pssm-ID: 215407 [Multi-domain]  Cd Length: 509  Bit Score: 280.48  E-value: 4.21e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  54 ARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATESFATSplsyrpVAIALDTKGPEIRT 133
Cdd:PLN02762  24 TRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEKGFA------VAVMMDTEGSEIHM 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 134 GVLQGGPESEVEivKGSQVLVTVDpKFQTRGDAKTVWVDYHNITRVVAVGGRIYIDDGLISL-VVQKIGPEgLVTEVEHG 212
Cdd:PLN02762  98 GDLGGASSAKAE--DGEEWTFTVR-KFDGSRPEFTIQVNYDGFAEDVKVGDELVVDGGMVRFeVIEKIGPD-VKCKCTDP 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 213 GILGSRKGVNL-------PNTEVDLPGLSEQDLLDLRFGVQHNVDIIFASFVRKASDVLAVRDALGPEGQN--IKIISKI 283
Cdd:PLN02762 174 GLLLPRANLTFwrdgslvRERNAMLPTISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYIAARSRDsdIGVIAKI 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 284 ENHEGVKKFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANA 363
Cdd:PLN02762 254 ESLDSLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVADVSEA 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 364 VLDGADCIMLSGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRR---AAPLSRDPTEVTAIGAVEASFKCCAAAI 440
Cdd:PLN02762 334 VRQRADALMLSGESAMGLYPEKALSVLRSVSLRMELWSREEKRHEALELpqlSSSLSDRISEEICNSAAKMANNLGVDAI 413

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 441 IVLTKTGRSAQLLSQYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYReppeaiWADDVDRRVQFGIESGKLRGFLRVGDL 520
Cdd:PLN02762 414 FVYTKHGHMASLLSRNRPDCPIFAFTDTTSVRRRLNLQWGLIPFRLD------FSDDMESNLNKTFSLLKARGMIKSGDL 487

                        490
                 ....*....|....*.
gi 185134818 521 VIVVTGWRPGSGYTNI 536
Cdd:PLN02762 488 VIAVSDLTPSSMLQSI 503
PRK08187 PRK08187
pyruvate kinase; Validated
 51-387 3.30e-55

pyruvate kinase; Validated


Pssm-ID: 236178  Cd Length: 493  Bit Score: 193.31  E-value: 3.30e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  51 PVAARSTSIIATI-GPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREATEsfATSplsyRPVAIALDTKGP 129
Cdd:PRK08187 129 RPAARRTRIMVTLpSEAADDPDFVLRLAERGMDCARINCAHDDPAAWQAMIGHLRQAER--ATG----RRCKILMDLAGP 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 130 EIRTGVLqGGPESEVEIVKGSQVLVTVDPKFqTRGDAKTVWVD--YHNITRVVAVGGRIYIDDGLISLVVQKIGPEGLVT 207
Cdd:PRK08187 203 KIRTGAV-AGPLGKTRLYTGDRLALVAQGPP-RRIDEEHFQVTctLPEILARLAVGARVWIDDGKLGARVERVGPGGALL 280

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 208 EVEHGGILGSR----KGVNLPNTEVDLPGLSEQDLLDLRFGVQHnVDIIFASFVRKASDVLAVRDAL----GPEGQNIKI 279
Cdd:PRK08187 281 EVTHARPKGLKlkpeKGLNFPDTALDLPALTEKDRADLDFVARH-ADLVGYSFVQSPGDVEALQAALaarrPDDWRKLGL 359

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 280 ISKIENHEGVKKFDEILEVSDG-----IMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTR 354
Cdd:PRK08187 360 VLKIETPRAVANLPELIVQAAGrqpfgVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSR 439

                        330       340       350
                 ....*....|....*....|....*....|...
gi 185134818 355 AETSDVANAvlDGADCIMLSgetaKGSFPVEAV 387
Cdd:PRK08187 440 AEMTDAAMA--ARAECVMLN----KGPYLVEAV 466
PRK14725 PRK14725
pyruvate kinase; Provisional
 26-412 5.12e-45

pyruvate kinase; Provisional


Pssm-ID: 237804  Cd Length: 608  Bit Score: 167.82  E-value: 5.12e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  26 QQQQLPAAMADTFLEHLCLLDIDSQ-----PVAARSTSIIATIgPASRSVDR--LKEMIKAGMNIARLNFSHGSHEYHAE 98
Cdd:PRK14725 105 GPAYPPEDTAVTFEEGDELLDEHAEallgpPPSGRPTRIMVTL-PTEAADDPdlVRRLLAAGMDIARINCAHDDPEAWRA 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  99 SIANIREATESFAtsplsyRPVAIALDTKGPEIRTGVLQGGPE-----------------SEVEIVKGS---------QV 152
Cdd:PRK14725 184 MIANVRTAEEELG------RRCRIAMDLAGPKLRTGPIAPGPRviklrptrdalgrvltpARLWLTASEspppspppgPV 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 153 LVTVDPKF-------------QTRGDAK--------------------------TVWVDYHNITRV-------------- 179
Cdd:PRK14725 258 GLPVDPEWlarlepgdelrftDARGKKRkltvtevddegvlaegsqtaylangtLLRLGRHDSTRVgglppveqklrlkv 337

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 180 -----------------------------------VAVGGRIYIDDGLISLVVQKIGPEGLVTEVEHGGILGSR----KG 220
Cdd:PRK14725 338 gdrlvltrddapgdpaqgdapparisctlpeafraARVGERVWFDDGKIGAVVVKVEADEVELRITHARPGGSKlkagKG 417

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 221 VNLPNTEVDLPGLSEQDLLDLRFGVQHnVDIIFASFVRKASDVLAVRDALGPEG-QNIKIISKIENHEGVKKFDEIL--- 296
Cdd:PRK14725 418 INLPDSHLPLPALTDKDLEDLAFVAKH-ADIVALSFVRSPEDVRLLLDALEKLGaDDLGVVLKIETRRAFENLPRILlea 496

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 297 --EVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLdgADCIMLS 374
Cdd:PRK14725 497 mrHPRFGVMIARGDLAVEVGFERLAEVQEEILWLCEAAHVPVIWATQVLESLAKKGLPSRAEITDAAMALR--AECVMLN 574

                        490       500       510
                 ....*....|....*....|....*....|....*...
gi 185134818 375 getaKGSFPVEAVMMQHAIAREAEAavYHRQLFEELRR 412
Cdd:PRK14725 575 ----KGPHIVEAVRVLDDILRRMEE--HQRKKRSLLRR 606
PykA2 COG3848
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
328-543 1.55e-38

Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];


Pssm-ID: 443058  Cd Length: 321  Bit Score: 143.50  E-value: 1.55e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 328 RCNLAGKPVVCATQMLESMITKARPTRAETSDVANAVLDGADCIMLSGETAKGSFPVEAVMMQHAIAREAEAAVYHRqlf 407
Cdd:COG3848    1 KCNAAGKPVITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEDLEYR--- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818 408 eELRRAAPLSRDPTEVTAIG------AVEASfkccAAAIIVLTKTGRSAQLLSQYRPRAAVIAVTRSAQAARQVHLSRGV 481
Cdd:COG3848   78 -EQRVPRAKESSTTITDAIShavattAADLG----AAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGV 152

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 185134818 482 FPLLYREPPEAIwaDDVDRRVQFGIESgklrGFLRVGDLVIVVTGWRPG-SGYTNIMRVLSVS 543
Cdd:COG3848  153 YPLLVEESASTD--EMFAVAVALALEA----GLVKDGDLVVITAGVPVGvSGTTNLLKVHVVG 209
PK_C pfam02887
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ...
 422-540 6.48e-34

Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.


Pssm-ID: 460738 [Multi-domain]  Cd Length: 114  Bit Score: 124.13  E-value: 6.48e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 185134818  422 EVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSQYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREppeaiwADDVDRR 501
Cdd:pfam02887   1 EAIAHAAVEAAEELGAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDE------AETTDEM 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 185134818  502 VQFGIESGKLRGFLRVGDLVIVVTGWRPG-SGYTNIMRVL 540
Cdd:pfam02887  75 LRRAVKVAKEAGLVKKGDLVVITAGVPFGvSGTTNTLKVI 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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