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Conserved domains on  [gi|291490665|ref|NP_036839|]
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pro-glucagon preproprotein [Rattus norvegicus]

Protein Classification

glucagon family hormone( domain architecture ID 10443965)

glucagon family hormone similar to glucagon, somatoliberin and VIP peptides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Hormone_2 pfam00123
Peptide hormone; This family contains glucagon, GIP, secretin and VIP.
 53-80 3.90e-12

Peptide hormone; This family contains glucagon, GIP, secretin and VIP.


:

Pssm-ID: 459681  Cd Length: 28  Bit Score: 57.45  E-value: 3.90e-12
                          10        20
                  ....*....|....*....|....*...
gi 291490665   53 HSQGTFTSDYSKYLDSRRAQDFVQWLMN 80
Cdd:pfam00123   1 HADGTFTSDYSKVLDQLAAKKFLQWLMN 28
Hormone_2 pfam00123
Peptide hormone; This family contains glucagon, GIP, secretin and VIP.
 146-173 1.44e-09

Peptide hormone; This family contains glucagon, GIP, secretin and VIP.


:

Pssm-ID: 459681  Cd Length: 28  Bit Score: 50.91  E-value: 1.44e-09
                          10        20
                  ....*....|....*....|....*...
gi 291490665  146 HADGSFSDEMNTILDNLATRDFINWLIQ 173
Cdd:pfam00123   1 HADGTFTSDYSKVLDQLAAKKFLQWLMN 28
Hormone_2 pfam00123
Peptide hormone; This family contains glucagon, GIP, secretin and VIP.
 98-125 5.17e-09

Peptide hormone; This family contains glucagon, GIP, secretin and VIP.


:

Pssm-ID: 459681  Cd Length: 28  Bit Score: 49.36  E-value: 5.17e-09
                          10        20
                  ....*....|....*....|....*...
gi 291490665   98 HAEGTFTSDVSSYLEGQAAKEFIAWLVK 125
Cdd:pfam00123   1 HADGTFTSDYSKVLDQLAAKKFLQWLMN 28
 
Name Accession Description Interval E-value
Hormone_2 pfam00123
Peptide hormone; This family contains glucagon, GIP, secretin and VIP.
 53-80 3.90e-12

Peptide hormone; This family contains glucagon, GIP, secretin and VIP.


Pssm-ID: 459681  Cd Length: 28  Bit Score: 57.45  E-value: 3.90e-12
                          10        20
                  ....*....|....*....|....*...
gi 291490665   53 HSQGTFTSDYSKYLDSRRAQDFVQWLMN 80
Cdd:pfam00123   1 HADGTFTSDYSKVLDQLAAKKFLQWLMN 28
GLUCA smart00070
Glucagon like hormones;
53-79 1.80e-11

Glucagon like hormones;


Pssm-ID: 128384  Cd Length: 27  Bit Score: 55.98  E-value: 1.80e-11
                           10        20
                   ....*....|....*....|....*..
gi 291490665    53 HSQGTFTSDYSKYLDSRRAQDFVQWLM 79
Cdd:smart00070   1 HADGTFTSDYSKYLDQLAAKKFLQWLM 27
Hormone_2 pfam00123
Peptide hormone; This family contains glucagon, GIP, secretin and VIP.
 146-173 1.44e-09

Peptide hormone; This family contains glucagon, GIP, secretin and VIP.


Pssm-ID: 459681  Cd Length: 28  Bit Score: 50.91  E-value: 1.44e-09
                          10        20
                  ....*....|....*....|....*...
gi 291490665  146 HADGSFSDEMNTILDNLATRDFINWLIQ 173
Cdd:pfam00123   1 HADGTFTSDYSKVLDQLAAKKFLQWLMN 28
Hormone_2 pfam00123
Peptide hormone; This family contains glucagon, GIP, secretin and VIP.
 98-125 5.17e-09

Peptide hormone; This family contains glucagon, GIP, secretin and VIP.


Pssm-ID: 459681  Cd Length: 28  Bit Score: 49.36  E-value: 5.17e-09
                          10        20
                  ....*....|....*....|....*...
gi 291490665   98 HAEGTFTSDVSSYLEGQAAKEFIAWLVK 125
Cdd:pfam00123   1 HADGTFTSDYSKVLDQLAAKKFLQWLMN 28
GLUCA smart00070
Glucagon like hormones;
98-124 7.97e-09

Glucagon like hormones;


Pssm-ID: 128384  Cd Length: 27  Bit Score: 49.05  E-value: 7.97e-09
                           10        20
                   ....*....|....*....|....*..
gi 291490665    98 HAEGTFTSDVSSYLEGQAAKEFIAWLV 124
Cdd:smart00070   1 HADGTFTSDYSKYLDQLAAKKFLQWLM 27
GLUCA smart00070
Glucagon like hormones;
146-172 7.07e-07

Glucagon like hormones;


Pssm-ID: 128384  Cd Length: 27  Bit Score: 43.66  E-value: 7.07e-07
                           10        20
                   ....*....|....*....|....*..
gi 291490665   146 HADGSFSDEMNTILDNLATRDFINWLI 172
Cdd:smart00070   1 HADGTFTSDYSKYLDQLAAKKFLQWLM 27
 
Name Accession Description Interval E-value
Hormone_2 pfam00123
Peptide hormone; This family contains glucagon, GIP, secretin and VIP.
 53-80 3.90e-12

Peptide hormone; This family contains glucagon, GIP, secretin and VIP.


Pssm-ID: 459681  Cd Length: 28  Bit Score: 57.45  E-value: 3.90e-12
                          10        20
                  ....*....|....*....|....*...
gi 291490665   53 HSQGTFTSDYSKYLDSRRAQDFVQWLMN 80
Cdd:pfam00123   1 HADGTFTSDYSKVLDQLAAKKFLQWLMN 28
GLUCA smart00070
Glucagon like hormones;
53-79 1.80e-11

Glucagon like hormones;


Pssm-ID: 128384  Cd Length: 27  Bit Score: 55.98  E-value: 1.80e-11
                           10        20
                   ....*....|....*....|....*..
gi 291490665    53 HSQGTFTSDYSKYLDSRRAQDFVQWLM 79
Cdd:smart00070   1 HADGTFTSDYSKYLDQLAAKKFLQWLM 27
Hormone_2 pfam00123
Peptide hormone; This family contains glucagon, GIP, secretin and VIP.
 146-173 1.44e-09

Peptide hormone; This family contains glucagon, GIP, secretin and VIP.


Pssm-ID: 459681  Cd Length: 28  Bit Score: 50.91  E-value: 1.44e-09
                          10        20
                  ....*....|....*....|....*...
gi 291490665  146 HADGSFSDEMNTILDNLATRDFINWLIQ 173
Cdd:pfam00123   1 HADGTFTSDYSKVLDQLAAKKFLQWLMN 28
Hormone_2 pfam00123
Peptide hormone; This family contains glucagon, GIP, secretin and VIP.
 98-125 5.17e-09

Peptide hormone; This family contains glucagon, GIP, secretin and VIP.


Pssm-ID: 459681  Cd Length: 28  Bit Score: 49.36  E-value: 5.17e-09
                          10        20
                  ....*....|....*....|....*...
gi 291490665   98 HAEGTFTSDVSSYLEGQAAKEFIAWLVK 125
Cdd:pfam00123   1 HADGTFTSDYSKVLDQLAAKKFLQWLMN 28
GLUCA smart00070
Glucagon like hormones;
98-124 7.97e-09

Glucagon like hormones;


Pssm-ID: 128384  Cd Length: 27  Bit Score: 49.05  E-value: 7.97e-09
                           10        20
                   ....*....|....*....|....*..
gi 291490665    98 HAEGTFTSDVSSYLEGQAAKEFIAWLV 124
Cdd:smart00070   1 HADGTFTSDYSKYLDQLAAKKFLQWLM 27
GLUCA smart00070
Glucagon like hormones;
146-172 7.07e-07

Glucagon like hormones;


Pssm-ID: 128384  Cd Length: 27  Bit Score: 43.66  E-value: 7.07e-07
                           10        20
                   ....*....|....*....|....*..
gi 291490665   146 HADGSFSDEMNTILDNLATRDFINWLI 172
Cdd:smart00070   1 HADGTFTSDYSKYLDQLAAKKFLQWLM 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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