NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|34577057|ref|NP_037412|]
View 

leucine-rich repeat transmembrane protein FLRT1 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
84-331 6.03e-26

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 110.79  E-value: 6.03e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057  84 TTLYLQNNQINNagIPQDLKTKVNVQVIYLYENDLDEFPINLPR--SLRELHLQDNNVRTIArDSLARIPLLEKLHLDDN 161
Cdd:COG4886 116 ESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN 192

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057 162 SVSTVSieeDAFADSKQLKLLFLSRNHLSSIPSGLP--HTLEELRLDDNRISTIPlhAFKGLNSLRRLVLDGNllanqRI 239
Cdd:COG4886 193 QITDLP---EPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNN-----QL 262

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057 240 AD-DTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLG 318
Cdd:COG4886 263 TDlPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342

                       250
                ....*....|...
gi 34577057 319 NLAQLLLRNNPWF 331
Cdd:COG4886 343 SLSLLALLTLLLL 355
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 300-406 1.71e-10

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 64.72  E-value: 1.71e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057    300 DLSNNNLTTLPRGLFDDLGNLAQLLLRNNPWFCGCNLMWLRDWVKARAA-VVNVRGLMCQGPEKVRG---MAIKDITSEM 375
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVkVRQPEAALCAGPGALAGqplLGIPLLDSGC 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 34577057    376 DE----CFETGPQGGVANAAAKTT-ASNHASATTPQ 406
Cdd:TIGR00864   81 DEeyvaCLKDNSSGGGAARSELVIfSAAHEGLFQPE 116
LRRNT smart00013
Leucine rich repeat N-terminal domain;
54-84 2.23e-06

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 44.62  E-value: 2.23e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 34577057     54 CPSVCRCDNGFIYCNDRGLTSIPADIPDDAT 84
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 441-505 1.39e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


:

Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.06  E-value: 1.39e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 34577057    441 IHVKALTADSIRITWKATLPAS--SFRLSWlRLGHSPAVGSITETLVQGDKTEYLLTALEPKSTYII 505
Cdd:smart00060   7 LRVTDVTSTSVTLSWEPPPDDGitGYIVGY-RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
84-331 6.03e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 110.79  E-value: 6.03e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057  84 TTLYLQNNQINNagIPQDLKTKVNVQVIYLYENDLDEFPINLPR--SLRELHLQDNNVRTIArDSLARIPLLEKLHLDDN 161
Cdd:COG4886 116 ESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN 192

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057 162 SVSTVSieeDAFADSKQLKLLFLSRNHLSSIPSGLP--HTLEELRLDDNRISTIPlhAFKGLNSLRRLVLDGNllanqRI 239
Cdd:COG4886 193 QITDLP---EPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNN-----QL 262

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057 240 AD-DTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLG 318
Cdd:COG4886 263 TDlPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342

                       250
                ....*....|...
gi 34577057 319 NLAQLLLRNNPWF 331
Cdd:COG4886 343 SLSLLALLTLLLL 355
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
58-329 2.19e-23

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 105.55  E-value: 2.19e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057   58 CRCDNGFIYCNDR-GLTSIPADIPDDATTLYLQNNQINNagIPQDLKTkvNVQVIYLYENDLDEFPINLPRSLRELHLQD 136
Cdd:PRK15370 175 CLKNNKTELRLKIlGLTTIPACIPEQITTLILDNNELKS--LPENLQG--NIKTLYANSNQLTSIPATLPDTIQEMELSI 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057  137 NNVRTIARdslaRIP-LLEKLHLDDNSVSTVSieeDAFADskQLKLLFLSRNHLSSIPSGLPHTLEELRLDDNRISTIPL 215
Cdd:PRK15370 251 NRITELPE----RLPsALQSLDLFHNKISCLP---ENLPE--ELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPE 321

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057  216 HAFKGLNSlrrLVLDGNLLANqrIADDTFSRLQNlteLSLVRNSLAAPPLNLPSAhLQKLYLQDNAISHIPYNTLAKMRE 295
Cdd:PRK15370 322 TLPPGLKT---LEAGENALTS--LPASLPPELQV---LDVSKNQITVLPETLPPT-ITTLDVSRNALTNLPENLPAALQI 392

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 34577057  296 LERldlSNNNLTTLPRGLFDDLGNLAQ---LLLRNNP 329
Cdd:PRK15370 393 MQA---SRNNLVRLPESLPHFRGEGPQptrIIVEYNP 426
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 84-311 1.40e-19

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 87.92  E-value: 1.40e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057  84 TTLYLQNNQINnaGIPqDLKTKVNVQVIYLYENDLDEFPiNLP--RSLRELHLQDNNVRTIarDSLARIPLLEKLHLDDN 161
Cdd:cd21340   5 THLYLNDKNIT--KID-NLSLCKNLKVLYLYDNKITKIE-NLEflTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGN 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057 162 SVSTVSieedAFADSKQLKLLFLSRNHLssiPSGlphtlEELRLDDNRISTIplhafkgLNSLRRLVLDGNllanqriad 241
Cdd:cd21340  79 RISVVE----GLENLTNLEELHIENQRL---PPG-----EKLTFDPRSLAAL-------SNSLRVLNISGN--------- 130

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 34577057 242 dtfsRLQNLTELSLVRNslaapplnlpsahLQKLYLQDNAISHIPY--NTLAKMRELERLDLSNNNLTTLPR 311
Cdd:cd21340 131 ----NIDSLEPLAPLRN-------------LEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPK 185
LRR_8 pfam13855
Leucine rich repeat;
271-329 2.33e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.46  E-value: 2.33e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 34577057   271 HLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNNP 329
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 300-406 1.71e-10

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 64.72  E-value: 1.71e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057    300 DLSNNNLTTLPRGLFDDLGNLAQLLLRNNPWFCGCNLMWLRDWVKARAA-VVNVRGLMCQGPEKVRG---MAIKDITSEM 375
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVkVRQPEAALCAGPGALAGqplLGIPLLDSGC 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 34577057    376 DE----CFETGPQGGVANAAAKTT-ASNHASATTPQ 406
Cdd:TIGR00864   81 DEeyvaCLKDNSSGGGAARSELVIfSAAHEGLFQPE 116
LRRCT smart00082
Leucine rich repeat C-terminal domain;
328-378 1.41e-08

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 51.28  E-value: 1.41e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 34577057    328 NPWFCGCNLMWLRDWVKARAAVVNVRGLMCQGPEKVRGmAIKDITSEMDEC 378
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
LRRNT smart00013
Leucine rich repeat N-terminal domain;
54-84 2.23e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 44.62  E-value: 2.23e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 34577057     54 CPSVCRCDNGFIYCNDRGLTSIPADIPDDAT 84
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 54-80 1.08e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 42.61  E-value: 1.08e-05
                          10        20
                  ....*....|....*....|....*..
gi 34577057    54 CPSVCRCDNGFIYCNDRGLTSIPADIP 80
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRR smart00370
Leucine-rich repeats, outliers;
293-316 1.37e-04

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 39.26  E-value: 1.37e-04
                           10        20
                   ....*....|....*....|....
gi 34577057    293 MRELERLDLSNNNLTTLPRGLFDD 316
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 441-505 1.39e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.06  E-value: 1.39e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 34577057    441 IHVKALTADSIRITWKATLPAS--SFRLSWlRLGHSPAVGSITETLVQGDKTEYLLTALEPKSTYII 505
Cdd:smart00060   7 LRVTDVTSTSVTLSWEPPPDDGitGYIVGY-RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
fn3 pfam00041
Fibronectin type III domain;
441-509 1.92e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.48  E-value: 1.92e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 34577057   441 IHVKALTADSIRITWKATLPASS----FRLSWLRLGHSpavGSITETLVQGDKTEYLLTALEPKSTYIICMVT 509
Cdd:pfam00041   6 LTVTDVTSTSLTVSWTPPPDGNGpitgYEVEYRPKNSG---EPWNEITVPGTTTSVTLTGLKPGTEYEVRVQA 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 441-505 5.48e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.40  E-value: 5.48e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 34577057 441 IHVKALTADSIRITWKA----TLPASSFRLSWLRLGHSPavgSITETLVQGDKTEYLLTALEPKSTYII 505
Cdd:cd00063   7 LRVTDVTSTSVTLSWTPpeddGGPITGYVVEYREKGSGD---WKEVEVTPGSETSYTLTGLKPGTEYEF 72
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
84-331 6.03e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 110.79  E-value: 6.03e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057  84 TTLYLQNNQINNagIPQDLKTKVNVQVIYLYENDLDEFPINLPR--SLRELHLQDNNVRTIArDSLARIPLLEKLHLDDN 161
Cdd:COG4886 116 ESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN 192

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057 162 SVSTVSieeDAFADSKQLKLLFLSRNHLSSIPSGLP--HTLEELRLDDNRISTIPlhAFKGLNSLRRLVLDGNllanqRI 239
Cdd:COG4886 193 QITDLP---EPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNN-----QL 262

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057 240 AD-DTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLG 318
Cdd:COG4886 263 TDlPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342

                       250
                ....*....|...
gi 34577057 319 NLAQLLLRNNPWF 331
Cdd:COG4886 343 SLSLLALLTLLLL 355
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-328 2.13e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 106.17  E-value: 2.13e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057  68 NDRGLTSIPADIPDDATTLYLQNNQINNAGIPQDLKTKVNVQVIYLYENDLDEFPINLPR--SLRELHLQDNNVRTIArD 145
Cdd:COG4886  75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLP-E 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057 146 SLARIPLLEKLHLDDNSVSTVSieeDAFADSKQLKLLFLSRNHLSSIPSGL--PHTLEELRLDDNRISTIPLhAFKGLNS 223
Cdd:COG4886 154 PLGNLTNLKSLDLSNNQLTDLP---EELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTN 229

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057 224 LRRLVLDGNllanqRIAD-DTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLS 302
Cdd:COG4886 230 LETLDLSNN-----QLTDlPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLL 304

                       250       260
                ....*....|....*....|....*.
gi 34577057 303 NNNLTTLPRGLFDDLGNLAQLLLRNN 328
Cdd:COG4886 305 LLLLNLLELLILLLLLTTLLLLLLLL 330
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
58-329 2.19e-23

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 105.55  E-value: 2.19e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057   58 CRCDNGFIYCNDR-GLTSIPADIPDDATTLYLQNNQINNagIPQDLKTkvNVQVIYLYENDLDEFPINLPRSLRELHLQD 136
Cdd:PRK15370 175 CLKNNKTELRLKIlGLTTIPACIPEQITTLILDNNELKS--LPENLQG--NIKTLYANSNQLTSIPATLPDTIQEMELSI 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057  137 NNVRTIARdslaRIP-LLEKLHLDDNSVSTVSieeDAFADskQLKLLFLSRNHLSSIPSGLPHTLEELRLDDNRISTIPL 215
Cdd:PRK15370 251 NRITELPE----RLPsALQSLDLFHNKISCLP---ENLPE--ELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPE 321

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057  216 HAFKGLNSlrrLVLDGNLLANqrIADDTFSRLQNlteLSLVRNSLAAPPLNLPSAhLQKLYLQDNAISHIPYNTLAKMRE 295
Cdd:PRK15370 322 TLPPGLKT---LEAGENALTS--LPASLPPELQV---LDVSKNQITVLPETLPPT-ITTLDVSRNALTNLPENLPAALQI 392

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 34577057  296 LERldlSNNNLTTLPRGLFDDLGNLAQ---LLLRNNP 329
Cdd:PRK15370 393 MQA---SRNNLVRLPESLPHFRGEGPQptrIIVEYNP 426
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
84-339 1.82e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 97.31  E-value: 1.82e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057  84 TTLYLQNNQINNAGIPQDLKTKVNVQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSV 163
Cdd:COG4886   3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057 164 STVSIEEDAFADSKQLKLLFLSRN-HLSSIPSglphtLEELRLDDNRISTIPlHAFKGLNSLRRLVLDGNLLANqriADD 242
Cdd:COG4886  83 SLLLLGLTDLGDLTNLTELDLSGNeELSNLTN-----LESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTD---LPE 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057 243 TFSRLQNLTELSLVRN---SLAAPPLNLPsaHLQKLYLQDNAISHIPyNTLAKMRELERLDLSNNNLTTLPRGLfDDLGN 319
Cdd:COG4886 154 PLGNLTNLKSLDLSNNqltDLPEELGNLT--NLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPL-ANLTN 229

                       250       260
                ....*....|....*....|....*.
gi 34577057 320 LAQLLLRNN-----PWFCGC-NLMWL 339
Cdd:COG4886 230 LETLDLSNNqltdlPELGNLtNLEEL 255
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 84-311 1.40e-19

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 87.92  E-value: 1.40e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057  84 TTLYLQNNQINnaGIPqDLKTKVNVQVIYLYENDLDEFPiNLP--RSLRELHLQDNNVRTIarDSLARIPLLEKLHLDDN 161
Cdd:cd21340   5 THLYLNDKNIT--KID-NLSLCKNLKVLYLYDNKITKIE-NLEflTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGN 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057 162 SVSTVSieedAFADSKQLKLLFLSRNHLssiPSGlphtlEELRLDDNRISTIplhafkgLNSLRRLVLDGNllanqriad 241
Cdd:cd21340  79 RISVVE----GLENLTNLEELHIENQRL---PPG-----EKLTFDPRSLAAL-------SNSLRVLNISGN--------- 130

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 34577057 242 dtfsRLQNLTELSLVRNslaapplnlpsahLQKLYLQDNAISHIPY--NTLAKMRELERLDLSNNNLTTLPR 311
Cdd:cd21340 131 ----NIDSLEPLAPLRN-------------LEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPK 185
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
65-318 3.06e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.76  E-value: 3.06e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057  65 IYCNDRGLTSIPADIPDDA--TTLYLQNNQINNagIPQDLKTKVNVQVIYLYENDLDEFPINL--PRSLRELHLQDNNVR 140
Cdd:COG4886 141 LDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTD--LPEELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLT 218

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057 141 TIArDSLARIPLLEKLHLDDNSVSTVSieedAFADSKQLKLLFLSRNHLSSIPSGLPHT-LEELRLDDNRISTIPLHAFK 219
Cdd:COG4886 219 DLP-EPLANLTNLETLDLSNNQLTDLP----ELGNLTNLEELDLSNNQLTDLPPLANLTnLKTLDLSNNQLTDLKLKELE 293

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057 220 GLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERL 299
Cdd:COG4886 294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373

                       250
                ....*....|....*....
gi 34577057 300 DLSNNNLTTLPRGLFDDLG 318
Cdd:COG4886 374 LLEATLLTLALLLLTLLLL 392
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
103-320 2.75e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 76.66  E-value: 2.75e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057  103 KTKVNVQVIY---LYENDLDEFPiNLPRSLRELH--LQDNNVR-TIARDSLARIPL-----LEKLHLDDNSVstVSIEED 171
Cdd:PRK15370 141 KDAVNYELIWsewVKEAPAKEAA-NREEAVQRMRdcLKNNKTElRLKILGLTTIPAcipeqITTLILDNNEL--KSLPEN 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057  172 AFADskqLKLLFLSRNHLSSIPSGLPHTLEELRLDDNRISTIPLHAFKGLNSlrrLVLDGNLLAnqrIADDTFSrlQNLT 251
Cdd:PRK15370 218 LQGN---IKTLYANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQS---LDLFHNKIS---CLPENLP--EELR 286

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 34577057  252 ELSLVRNSLAAPPLNLPSAhLQKLYLQDNAISHIPyNTLAKmrELERLDLSNNNLTTLPRGLFDDLGNL 320
Cdd:PRK15370 287 YLSVYDNSIRTLPAHLPSG-ITHLNVQSNSLTALP-ETLPP--GLKTLEAGENALTSLPASLPPELQVL 351
LRR_8 pfam13855
Leucine rich repeat;
271-329 2.33e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.46  E-value: 2.33e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 34577057   271 HLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNNP 329
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-327 8.72e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 65.25  E-value: 8.72e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057   75 IPADI--PDDATTLYLQNNQINNAgIPQDLKTKVNVQVIYLYENDLD-EFPINLP--RSLRELHLQDNNVRTIARDSLAR 149
Cdd:PLN00113 348 IPKNLgkHNNLTVLDLSTNNLTGE-IPEGLCSSGNLFKLILFSNSLEgEIPKSLGacRSLRRVRLQDNSFSGELPSEFTK 426

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057  150 IPLLEKLHLDDNSVSTvSIEEDAFaDSKQLKLLFLSRNHLSSipsGLPHT-----LEELRLDDNRIS-TIPLhAFKGLNS 223
Cdd:PLN00113 427 LPLVYFLDISNNNLQG-RINSRKW-DMPSLQMLSLARNKFFG---GLPDSfgskrLENLDLSRNQFSgAVPR-KLGSLSE 500

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057  224 LRRLVLDGNLLANQriADDTFSRLQNLTELSLVRNSLAApplnlpsahlqklylqdnaisHIPyNTLAKMRELERLDLSN 303
Cdd:PLN00113 501 LMQLKLSENKLSGE--IPDELSSCKKLVSLDLSHNQLSG---------------------QIP-ASFSEMPVLSQLDLSQ 556

                        250       260
                 ....*....|....*....|....*
gi 34577057  304 NNLT-TLPRglfdDLGNLAQLLLRN 327
Cdd:PLN00113 557 NQLSgEIPK----NLGNVESLVQVN 577
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 300-406 1.71e-10

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 64.72  E-value: 1.71e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057    300 DLSNNNLTTLPRGLFDDLGNLAQLLLRNNPWFCGCNLMWLRDWVKARAA-VVNVRGLMCQGPEKVRG---MAIKDITSEM 375
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVkVRQPEAALCAGPGALAGqplLGIPLLDSGC 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 34577057    376 DE----CFETGPQGGVANAAAKTT-ASNHASATTPQ 406
Cdd:TIGR00864   81 DEeyvaCLKDNSSGGGAARSELVIfSAAHEGLFQPE 116
LRR_8 pfam13855
Leucine rich repeat;
178-234 2.99e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 2.99e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 34577057   178 QLKLLFLSRNHLSSIP----SGLPHtLEELRLDDNRISTIPLHAFKGLNSLRRLVLDGNLL 234
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDdgafKGLSN-LKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 127-332 6.30e-10

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 61.22  E-value: 6.30e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057 127 RSLRELHLQDNNVRTIA----RDSLARIPLLEKLHLDDN----SVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGL-- 196
Cdd:cd00116  23 LCLQVLRLEGNTLGEEAakalASALRPQPSLKELCLSLNetgrIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVle 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057 197 ----PHTLEELRLDDNRISTIPL-HAFKGLNS----LRRLVLDGNLLANQRIAD--DTFSRLQNLTELSLVRNSLAAPPL 265
Cdd:cd00116 103 sllrSSSLQELKLNNNGLGDRGLrLLAKGLKDlppaLEKLVLGRNRLEGASCEAlaKALRANRDLKELNLANNGIGDAGI 182

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 34577057 266 NL------PSAHLQKLYLQDNAISHIPY----NTLAKMRELERLDLSNNNLTTLP-RGLFDDLGNLAQLLLRNNPWFC 332
Cdd:cd00116 183 RAlaeglkANCNLEVLDLNNNGLTDEGAsalaETLASLKSLEVLNLGDNNLTDAGaAALASALLSPNISLLTLSLSCN 260
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
62-307 5.53e-09

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 59.41  E-value: 5.53e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057   62 NGFIYCNDRGLTSIPADIPDDATTLYLQNNQINN-AGIPQDLKTkvnvqvIYLYENDLDEFPInLPRSLRELHLQDNNVR 140
Cdd:PRK15387 203 NAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSlPALPPELRT------LEVSGNQLTSLPV-LPPGLLELSIFSNPLT 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057  141 T------------IARDSLARIPL----LEKLHLDDNSVSTVSieedafADSKQLKLLFLSRNHLSSIPSgLPHTLEELR 204
Cdd:PRK15387 276 HlpalpsglcklwIFGNQLTSLPVlppgLQELSVSDNQLASLP------ALPSELCKLWAYNNQLTSLPT-LPSGLQELS 348

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057  205 LDDNRISTIP---------------LHAFKGLNS-LRRLVLDGNLLANQRIADdtfsrlQNLTELSLVRNSLAAPPLnLP 268
Cdd:PRK15387 349 VSDNQLASLPtlpselyklwaynnrLTSLPALPSgLKELIVSGNRLTSLPVLP------SELKELMVSGNRLTSLPM-LP 421

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 34577057  269 SAhLQKLYLQDNAISHIPyNTLAKMRELERLDLSNNNLT 307
Cdd:PRK15387 422 SG-LLSLSVYRNQLTRLP-ESLIHLSSETTVNLEGNPLS 458
LRRCT smart00082
Leucine rich repeat C-terminal domain;
328-378 1.41e-08

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 51.28  E-value: 1.41e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 34577057    328 NPWFCGCNLMWLRDWVKARAAVVNVRGLMCQGPEKVRGmAIKDITSEMDEC 378
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
LRR_8 pfam13855
Leucine rich repeat;
127-189 3.28e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 3.28e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 34577057   127 RSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVSTvsIEEDAFADSKQLKLLFLSRNHL 189
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
223-306 6.31e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 6.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057   223 SLRRLVLDGNLLanQRIADDTFSRLQNLTELslvrnslaapplnlpsahlqklYLQDNAISHIPYNTLAKMRELERLDLS 302
Cdd:pfam13855   2 NLRSLDLSNNRL--TSLDDGAFKGLSNLKVL----------------------DLSNNLLTTLSPGAFSGLPSLRYLDLS 57


                  ....
gi 34577057   303 NNNL 306
Cdd:pfam13855  58 GNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 98-328 6.83e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.93  E-value: 6.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057   98 IPQDLKTKVNVQVIYLYENDLD-EFPI---NLPRsLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVsTVSIEEDAF 173
Cdd:PLN00113 300 IPELVIQLQNLEILHLFSNNFTgKIPValtSLPR-LQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNL-TGEIPEGLC 377

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057  174 ADSKQLKLLFLSRNHLSSIPSGLP--HTLEELRLDDNRISTIPLHAFKGLNSLRRLVLDGNLLANqRIADDTFSrLQNLT 251
Cdd:PLN00113 378 SSGNLFKLILFSNSLEGEIPKSLGacRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQG-RINSRKWD-MPSLQ 455

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057  252 ELSLVRNSLAApplNLP----SAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLT-TLPRGLfDDLGNLAQLLLR 326
Cdd:PLN00113 456 MLSLARNKFFG---GLPdsfgSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDEL-SSCKKLVSLDLS 531


                 ..
gi 34577057  327 NN 328
Cdd:PLN00113 532 HN 533
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 129-315 8.44e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.59  E-value: 8.44e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057 129 LRELHLQDN-----NVRTIArdSLARIPLLEKLHLDDNSVST--VSIEEDAFADSK-QLKLLFLSRNHLSSIPS-----G 195
Cdd:cd00116  83 LQELDLSDNalgpdGCGVLE--SLLRSSSLQELKLNNNGLGDrgLRLLAKGLKDLPpALEKLVLGRNRLEGASCealakA 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057 196 LPH--TLEELRLDDNRIST--IPL--HAFKGLNSLRRLVLDGNLLANQRIAD--DTFSRLQNLTELSLVRNSLAapplNL 267
Cdd:cd00116 161 LRAnrDLKELNLANNGIGDagIRAlaEGLKANCNLEVLDLNNNGLTDEGASAlaETLASLKSLEVLNLGDNNLT----DA 236

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 34577057 268 PSAHLQKLYLQDNaishipyntlakmRELERLDLSNNNLT-----TLPRGLFD 315
Cdd:cd00116 237 GAAALASALLSPN-------------ISLLTLSLSCNDITddgakDLAEVLAE 276
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 85-328 2.15e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.00  E-value: 2.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057   85 TLYLQNNQINnAGIPQDLKTkvnvqviylyendldefpinLPRSLRELHLQDNNVR-TIARDSlarIPLLEKLHLDDNSV 163
Cdd:PLN00113  97 TINLSNNQLS-GPIPDDIFT--------------------TSSSLRYLNLSNNNFTgSIPRGS---IPNLETLDLSNNML 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057  164 STVSIEEDAFADSkqLKLLFLSRNHLSS-IPSGLPH--TLEELRLDDNR-ISTIPlHAFKGLNSLRRLVLDGNLLANQri 239
Cdd:PLN00113 153 SGEIPNDIGSFSS--LKVLDLGGNVLVGkIPNSLTNltSLEFLTLASNQlVGQIP-RELGQMKSLKWIYLGYNNLSGE-- 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057  240 ADDTFSRLQNLTELSLVRNSLAAPplnLPSA-----HLQKLYLQDNAIS-HIPyNTLAKMRELERLDLSNNNLTTLPRGL 313
Cdd:PLN00113 228 IPYEIGGLTSLNHLDLVYNNLTGP---IPSSlgnlkNLQYLFLYQNKLSgPIP-PSIFSLQKLISLDLSDNSLSGEIPEL 303

                        250
                 ....*....|....*
gi 34577057  314 FDDLGNLAQLLLRNN 328
Cdd:PLN00113 304 VIQLQNLEILHLFSN 318
LRRNT smart00013
Leucine rich repeat N-terminal domain;
54-84 2.23e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 44.62  E-value: 2.23e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 34577057     54 CPSVCRCDNGFIYCNDRGLTSIPADIPDDAT 84
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 54-80 1.08e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 42.61  E-value: 1.08e-05
                          10        20
                  ....*....|....*....|....*..
gi 34577057    54 CPSVCRCDNGFIYCNDRGLTSIPADIP 80
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRR smart00370
Leucine-rich repeats, outliers;
293-316 1.37e-04

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 39.26  E-value: 1.37e-04
                           10        20
                   ....*....|....*....|....
gi 34577057    293 MRELERLDLSNNNLTTLPRGLFDD 316
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
293-316 1.37e-04

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 39.26  E-value: 1.37e-04
                           10        20
                   ....*....|....*....|....
gi 34577057    293 MRELERLDLSNNNLTTLPRGLFDD 316
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 441-505 1.39e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.06  E-value: 1.39e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 34577057    441 IHVKALTADSIRITWKATLPAS--SFRLSWlRLGHSPAVGSITETLVQGDKTEYLLTALEPKSTYII 505
Cdd:smart00060   7 LRVTDVTSTSVTLSWEPPPDDGitGYIVGY-RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
fn3 pfam00041
Fibronectin type III domain;
441-509 1.92e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.48  E-value: 1.92e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 34577057   441 IHVKALTADSIRITWKATLPASS----FRLSWLRLGHSpavGSITETLVQGDKTEYLLTALEPKSTYIICMVT 509
Cdd:pfam00041   6 LTVTDVTSTSLTVSWTPPPDGNGpitgYEVEYRPKNSG---EPWNEITVPGTTTSVTLTGLKPGTEYEVRVQA 75
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 84-210 2.01e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.40  E-value: 2.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057  84 TTLYLQNNQINNAG---IPQDLKTKVNVQVIYLYENDL-DEFPINLPRSLR------ELHLQDNNVRTIARDSLARI--- 150
Cdd:COG5238 267 ETLYLSGNQIGAEGaiaLAKALQGNTTLTSLDLSVNRIgDEGAIALAEGLQgnktlhTLNLAYNGIGAQGAIALAKAlqe 346

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 34577057 151 -PLLEKLHLDDNSVSTVSIEE--DAFADSKQLKLLFLSRNHLSS------IPSGLPHTLEELRLDDNRI 210
Cdd:COG5238 347 nTTLHSLDLSDNQIGDEGAIAlaKYLEGNTTLRELNLGKNNIGKqgaealIDALQTNRLHTLILDGNLI 415
LRR_8 pfam13855
Leucine rich repeat;
294-328 3.42e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 3.42e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 34577057   294 RELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNN 328
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN 35
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 441-505 5.48e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.40  E-value: 5.48e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 34577057 441 IHVKALTADSIRITWKA----TLPASSFRLSWLRLGHSPavgSITETLVQGDKTEYLLTALEPKSTYII 505
Cdd:cd00063   7 LRVTDVTSTSVTLSWTPpeddGGPITGYVVEYREKGSGD---WKEVEVTPGSETSYTLTGLKPGTEYEF 72
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 271-308 3.30e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 3.30e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 34577057   271 HLQKLYLQDNAISHIPynTLAKMRELERLDLSNNNLTT 308
Cdd:pfam12799   2 NLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNKIT 37
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 153-251 7.20e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 37.14  E-value: 7.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577057   153 LEKLHLDDNsvsTVSIEEDAFADSKQLKLLFLSRNhLSSIPSglpHT-----LEELRLDDNrISTIPLHAFKGLNSLRRL 227
Cdd:pfam13306  13 LTSITIPSS---LTSIGEYAFSNCTSLKSITLPSS-LTSIGS---YAfyncsLTSITIPSS-LTSIGEYAFSNCSNLKSI 84

                          90       100
                  ....*....|....*....|....*.
gi 34577057   228 VLDGNLlanQRIADDTF--SRLQNLT 251
Cdd:pfam13306  85 TLPSNL---TSIGSYAFsnCSLKSIT 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH