NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|7019383|ref|NP_037413|]
View 

leucine-rich repeat transmembrane protein FLRT3 precursor [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-308 9.06e-23

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.16  E-value: 9.06e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383   61 TTLYLQNNQINNagIPSDLKNLLKVERIYLYHNSLDEFPTNLPKYV--KELHLQENNIRTITyDSLSKIPYLEELHLDDN 138
Cdd:COG4886 116 ESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN 192

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383  139 SVSAVSIEegaFRDSNYLRLLFLSRNHLSTIPWGLPR--TIEELRLDDNRISTIssPSLQGLTSLKRLVLDGNLLNNhgl 216
Cdd:COG4886 193 QITDLPEP---LGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTD--- 264

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383  217 gDKVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDN 296
Cdd:COG4886 265 -LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALS 343

                       250
                ....*....|..
gi 7019383  297 ITQLILRNNPWY 308
Cdd:COG4886 344 LSLLALLTLLLL 355
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 277-354 3.24e-09

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 60.48  E-value: 3.24e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 7019383     277 DMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKV-NVRGLMCQAPEKVRGMAIkdLNAELFD 354
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrQPEAALCAGPGALAGQPL--LGIPLLD 77
LRRNT smart00013
Leucine rich repeat N-terminal domain;
31-61 6.78e-05

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 40.38  E-value: 6.78e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 7019383      31 CPSVCRCDAGFIYCNDRFLTSIPTGIPEDAT 61
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 413-478 5.97e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam00041:

Pssm-ID: 473895 [Multi-domain]  Cd Length: 85  Bit Score: 38.94  E-value: 5.97e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383    413 ITVKSVTSDTIHISWKLAL----PMTALRLSWLKLGHSpafGSITETIVTGERSEYLVTALEPDSPYKVC 478
Cdd:pfam00041   6 LTVTDVTSTSLTVSWTPPPdgngPITGYEVEYRPKNSG---EPWNEITVPGTTTSVTLTGLKPGTEYEVR 72
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-308 9.06e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.16  E-value: 9.06e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383   61 TTLYLQNNQINNagIPSDLKNLLKVERIYLYHNSLDEFPTNLPKYV--KELHLQENNIRTITyDSLSKIPYLEELHLDDN 138
Cdd:COG4886 116 ESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN 192

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383  139 SVSAVSIEegaFRDSNYLRLLFLSRNHLSTIPWGLPR--TIEELRLDDNRISTIssPSLQGLTSLKRLVLDGNLLNNhgl 216
Cdd:COG4886 193 QITDLPEP---LGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTD--- 264

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383  217 gDKVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDN 296
Cdd:COG4886 265 -LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALS 343

                       250
                ....*....|..
gi 7019383  297 ITQLILRNNPWY 308
Cdd:COG4886 344 LSLLALLTLLLL 355
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
44-306 1.89e-19

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 92.84  E-value: 1.89e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383    44 CNDRF-LTSIPTGIPEDATTLYLQNNQINNagIPSDLKNLLKveRIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITyd 122
Cdd:PRK15370 184 RLKILgLTTIPACIPEQITTLILDNNELKS--LPENLQGNIK--TLYANSNQLTSIPATLPDTIQEMELSINRITELP-- 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383   123 slSKIPY-LEELHLDDNSVSAV--SIEEGafrdsnyLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQGlt 199
Cdd:PRK15370 258 --ERLPSaLQSLDLFHNKISCLpeNLPEE-------LRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPG-- 326

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383   200 sLKRLVLDGNLLNNhgLGDKVFFNLVNlteLSLVRNSLTAAPVNLPGTnLRKLYLQDNHINRVPPNAFSYLRQlyrLDMS 279
Cdd:PRK15370 327 -LKTLEAGENALTS--LPASLPPELQV---LDVSKNQITVLPETLPPT-ITTLDVSRNALTNLPENLPAALQI---MQAS 396

                        250       260       270
                 ....*....|....*....|....*....|
gi 7019383   280 NNNLSNLPQGI---FDDLDNITQLILRNNP 306
Cdd:PRK15370 397 RNNLVRLPESLphfRGEGPQPTRIIVEYNP 426
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 42-230 3.95e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 74.82  E-value: 3.95e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383   42 IYCNDRFLTSIPT-GIPEDATTLYLQNNQINNagIPsDLKNLLKVERIYLYHNSLDEFP--TNLPKYVKeLHLQENNIRT 118
Cdd:cd21340   7 LYLNDKNITKIDNlSLCKNLKVLYLYDNKITK--IE-NLEFLTNLTHLYLQNNQIEKIEnlENLVNLKK-LYLGGNRISV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383  119 ITydSLSKIPYLEELHL-------------DDNSVSAVsieegafrdSNYLRLLFLSRNHLSTIP--WGLPRtIEELRLD 183
Cdd:cd21340  83 VE--GLENLTNLEELHIenqrlppgekltfDPRSLAAL---------SNSLRVLNISGNNIDSLEplAPLRN-LEQLDAS 150

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 7019383  184 DNRISTIS--SPSLQGLTSLKRLVLDGN-LLNNHGLGDKVFFNLVNLTEL 230
Cdd:cd21340 151 NNQISDLEelLDLLSSWPSLRELDLTGNpVCKKPKYRDKIILASKSLEVL 200
LRR_8 pfam13855
Leucine rich repeat;
247-306 8.14e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.92  E-value: 8.14e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383    247 TNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNP 306
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 277-354 3.24e-09

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 60.48  E-value: 3.24e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 7019383     277 DMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKV-NVRGLMCQAPEKVRGMAIkdLNAELFD 354
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrQPEAALCAGPGALAGQPL--LGIPLLD 77
LRRCT smart00082
Leucine rich repeat C-terminal domain;
305-356 4.14e-08

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 49.74  E-value: 4.14e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 7019383     305 NPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGmAIKDLNAELFDCK 356
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKCP 51
LRRNT smart00013
Leucine rich repeat N-terminal domain;
31-61 6.78e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 40.38  E-value: 6.78e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 7019383      31 CPSVCRCDAGFIYCNDRFLTSIPTGIPEDAT 61
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
fn3 pfam00041
Fibronectin type III domain;
413-478 5.97e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.94  E-value: 5.97e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383    413 ITVKSVTSDTIHISWKLAL----PMTALRLSWLKLGHSpafGSITETIVTGERSEYLVTALEPDSPYKVC 478
Cdd:pfam00041   6 LTVTDVTSTSLTVSWTPPPdgngPITGYEVEYRPKNSG---EPWNEITVPGTTTSVTLTGLKPGTEYEVR 72
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 31-57 1.85e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 36.07  E-value: 1.85e-03
                          10        20
                  ....*....|....*....|....*..
gi 7019383     31 CPSVCRCDAGFIYCNDRFLTSIPTGIP 57
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 413-477 3.66e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 36.82  E-value: 3.66e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7019383     413 ITVKSVTSDTIHISWKLALP--MTALRLSWlKLGHSPAFGSITETIVTGERSEYLVTALEPDSPYKV 477
Cdd:smart00060   7 LRVTDVTSTSVTLSWEPPPDdgITGYIVGY-RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-308 9.06e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.16  E-value: 9.06e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383   61 TTLYLQNNQINNagIPSDLKNLLKVERIYLYHNSLDEFPTNLPKYV--KELHLQENNIRTITyDSLSKIPYLEELHLDDN 138
Cdd:COG4886 116 ESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN 192

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383  139 SVSAVSIEegaFRDSNYLRLLFLSRNHLSTIPWGLPR--TIEELRLDDNRISTIssPSLQGLTSLKRLVLDGNLLNNhgl 216
Cdd:COG4886 193 QITDLPEP---LGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTD--- 264

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383  217 gDKVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDN 296
Cdd:COG4886 265 -LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALS 343

                       250
                ....*....|..
gi 7019383  297 ITQLILRNNPWY 308
Cdd:COG4886 344 LSLLALLTLLLL 355
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
45-305 1.01e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.16  E-value: 1.01e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383   45 NDRFLTSIPTGIPEDATTLYLQNNQINNAGIPSDLKNLLKVERIYLYHNSLDEFPTNLP--KYVKELHLQENNIRTITyD 122
Cdd:COG4886  75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLP-E 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383  123 SLSKIPYLEELHLDDNSVSAVSIEegaFRDSNYLRLLFLSRNHLSTIPWGL--PRTIEELRLDDNRISTISSPsLQGLTS 200
Cdd:COG4886 154 PLGNLTNLKSLDLSNNQLTDLPEE---LGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPEP-LANLTN 229

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383  201 LKRLVLDGNLLNNhgLGDkvFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSN 280
Cdd:COG4886 230 LETLDLSNNQLTD--LPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLL 305

                       250       260
                ....*....|....*....|....*
gi 7019383  281 NNLSNLPQGIFDDLDNITQLILRNN 305
Cdd:COG4886 306 LLLNLLELLILLLLLTTLLLLLLLL 330
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-300 2.75e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.93  E-value: 2.75e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383   49 LTSIPTGIPE--DATTLYLQNNQINNagIPSDLKNLLKVERIYLYHNSLDEFPT---NLPKyVKELHLQENNIRTITyDS 123
Cdd:COG4886 125 LTDLPEELANltNLKELDLSNNQLTD--LPEPLGNLTNLKSLDLSNNQLTDLPEelgNLTN-LKELDLSNNQITDLP-EP 200

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383  124 LSKIPYLEELHLDDNSVSAVSIEegaFRDSNYLRLLFLSRNHLSTIPW--GLPRtIEELRLDDNRISTIssPSLQGLTSL 201
Cdd:COG4886 201 LGNLTNLEELDLSGNQLTDLPEP---LANLTNLETLDLSNNQLTDLPElgNLTN-LEELDLSNNQLTDL--PPLANLTNL 274

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383  202 KRLVLDGNLLNNHGLgdKVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNN 281
Cdd:COG4886 275 KTLDLSNNQLTDLKL--KELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTL 352

                       250
                ....*....|....*....
gi 7019383  282 NLSNLPQGIFDDLDNITQL 300
Cdd:COG4886 353 LLLLNLLSLLLTLLLTLGL 371
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
44-306 1.89e-19

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 92.84  E-value: 1.89e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383    44 CNDRF-LTSIPTGIPEDATTLYLQNNQINNagIPSDLKNLLKveRIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITyd 122
Cdd:PRK15370 184 RLKILgLTTIPACIPEQITTLILDNNELKS--LPENLQGNIK--TLYANSNQLTSIPATLPDTIQEMELSINRITELP-- 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383   123 slSKIPY-LEELHLDDNSVSAV--SIEEGafrdsnyLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQGlt 199
Cdd:PRK15370 258 --ERLPSaLQSLDLFHNKISCLpeNLPEE-------LRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPG-- 326

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383   200 sLKRLVLDGNLLNNhgLGDKVFFNLVNlteLSLVRNSLTAAPVNLPGTnLRKLYLQDNHINRVPPNAFSYLRQlyrLDMS 279
Cdd:PRK15370 327 -LKTLEAGENALTS--LPASLPPELQV---LDVSKNQITVLPETLPPT-ITTLDVSRNALTNLPENLPAALQI---MQAS 396

                        250       260       270
                 ....*....|....*....|....*....|
gi 7019383   280 NNNLSNLPQGI---FDDLDNITQLILRNNP 306
Cdd:PRK15370 397 RNNLVRLPESLphfRGEGPQPTRIIVEYNP 426
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 42-230 3.95e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 74.82  E-value: 3.95e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383   42 IYCNDRFLTSIPT-GIPEDATTLYLQNNQINNagIPsDLKNLLKVERIYLYHNSLDEFP--TNLPKYVKeLHLQENNIRT 118
Cdd:cd21340   7 LYLNDKNITKIDNlSLCKNLKVLYLYDNKITK--IE-NLEFLTNLTHLYLQNNQIEKIEnlENLVNLKK-LYLGGNRISV 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383  119 ITydSLSKIPYLEELHL-------------DDNSVSAVsieegafrdSNYLRLLFLSRNHLSTIP--WGLPRtIEELRLD 183
Cdd:cd21340  83 VE--GLENLTNLEELHIenqrlppgekltfDPRSLAAL---------SNSLRVLNISGNNIDSLEplAPLRN-LEQLDAS 150

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 7019383  184 DNRISTIS--SPSLQGLTSLKRLVLDGN-LLNNHGLGDKVFFNLVNLTEL 230
Cdd:cd21340 151 NNQISDLEelLDLLSSWPSLRELDLTGNpVCKKPKYRDKIILASKSLEVL 200
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-305 8.70e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.81  E-value: 8.70e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383   79 LKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRL 158
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383  159 LFLSRNHLSTIPWGLPRtIEELRLDDNRistisspSLQGLTSLKRLVLDGNLLNNhgLGDKvFFNLVNLTELSLVRNSLT 238
Cdd:COG4886  81 LLSLLLLGLTDLGDLTN-LTELDLSGNE-------ELSNLTNLESLDLSGNQLTD--LPEE-LANLTNLKELDLSNNQLT 149

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7019383  239 AAPVNLPG-TNLRKLYLQDNHINRVpPNAFSYLRQLYRLDMSNNNLSNLPQGIFdDLDNITQLILRNN 305
Cdd:COG4886 150 DLPEPLGNlTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEPLG-NLTNLEELDLSGN 215
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 61-241 8.79e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.97  E-value: 8.79e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383   61 TTLYLQNNQINNAGIPSDLKNlLKVerIYLYHNSLDEFPtNLPKYVK--ELHLQENNIRTItyDSLSKIPYLEELHLDDN 138
Cdd:cd21340   5 THLYLNDKNITKIDNLSLCKN-LKV--LYLYDNKITKIE-NLEFLTNltHLYLQNNQIEKI--ENLENLVNLKKLYLGGN 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383  139 SVSAVsieEGaFRDSNYLRLLFLSRNHLstiPWGL-----PRTIEELR-----LD--DNRISTISspSLQGLTSLKRLVL 206
Cdd:cd21340  79 RISVV---EG-LENLTNLEELHIENQRL---PPGEkltfdPRSLAALSnslrvLNisGNNIDSLE--PLAPLRNLEQLDA 149

                       170       180       190
                ....*....|....*....|....*....|....*
gi 7019383  207 DGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAP 241
Cdd:cd21340 150 SNNQISDLEELLDLLSSWPSLRELDLTGNPVCKKP 184
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
123-306 2.04e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.66  E-value: 2.04e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383  123 SLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLK 202
Cdd:COG4886  20 LLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLT 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383  203 RLVLDGNllnnhglgdKVFFNLVNLTELSLVRNSLTAAPVNLPG-TNLRKLYLQDNHINRVPPnAFSYLRQLYRLDMSNN 281
Cdd:COG4886 100 ELDLSGN---------EELSNLTNLESLDLSGNQLTDLPEELANlTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNN 169

                       170       180
                ....*....|....*....|....*
gi 7019383  282 NLSNLPQGIfDDLDNITQLILRNNP 306
Cdd:COG4886 170 QLTDLPEEL-GNLTNLKELDLSNNQ 193
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
29-272 1.06e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 71.27  E-value: 1.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383    29 KSCPSVCRCDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINN--AGIPSDLKNLLkveriyLYHNSLDEFPTNLPKYV 106
Cdd:PRK15370 212 KSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITElpERLPSALQSLD------LFHNKISCLPENLPEEL 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383   107 KELHLQENNIRTITYDSLSKIpylEELHLDDNSVSAV--SIEEGafrdsnyLRLLFLSRNHLSTIPWGLPRTIEELRLDD 184
Cdd:PRK15370 286 RYLSVYDNSIRTLPAHLPSGI---THLNVQSNSLTALpeTLPPG-------LKTLEAGENALTSLPASLPPELQVLDVSK 355

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383   185 NRISTIssPSLQGLTslkrlvldgnllnnhglgdkvffnlvnLTELSLVRNSLTAAPVNLPGTnLRKLYLQDNHINRVPP 264
Cdd:PRK15370 356 NQITVL--PETLPPT---------------------------ITTLDVSRNALTNLPENLPAA-LQIMQASRNNLVRLPE 405


                 ....*...
gi 7019383   265 NAFSYLRQ 272
Cdd:PRK15370 406 SLPHFRGE 413
LRR_8 pfam13855
Leucine rich repeat;
247-306 8.14e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.92  E-value: 8.14e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383    247 TNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNP 306
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 106-305 3.93e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 63.33  E-value: 3.93e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383   106 VKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAvSIEEGAFRDSNYLRLLFLSRNHLS-TIPWGLPRTIEELRLDD 184
Cdd:PLN00113  71 VVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSG-PIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSN 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383   185 NRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDkvFFNLVNLTELSLVRNSLTAA-PVNLPGT-NLRKLYLQDNHINRV 262
Cdd:PLN00113 150 NMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNS--LTNLTSLEFLTLASNQLVGQiPRELGQMkSLKWIYLGYNNLSGE 227

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 7019383   263 PPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNN 305
Cdd:PLN00113 228 IPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQN 270
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-252 2.65e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.56  E-value: 2.65e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383   61 TTLYLQNNQINNagIPSDLKNLLKVERIYLYHNSLDEFP--TNLPKyVKELHLQENNIRTItyDSLSKIPYLEELHLDDN 138
Cdd:COG4886 208 EELDLSGNQLTD--LPEPLANLTNLETLDLSNNQLTDLPelGNLTN-LEELDLSNNQLTDL--PPLANLTNLKTLDLSNN 282

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383  139 SVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGD 218
Cdd:COG4886 283 QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLL 362

                       170       180       190
                ....*....|....*....|....*....|....
gi 7019383  219 KVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKL 252
Cdd:COG4886 363 LTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTT 396
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 277-354 3.24e-09

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 60.48  E-value: 3.24e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 7019383     277 DMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKV-NVRGLMCQAPEKVRGMAIkdLNAELFD 354
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrQPEAALCAGPGALAGQPL--LGIPLLD 77
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 120-259 5.24e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 58.14  E-value: 5.24e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383  120 TYDSLSKIPYLEELHLDDNSV--SAVSIEEGAFRDSNY-LRLLFLSRNHL---STIPWG--LP--RTIEELRLDDNRIST 189
Cdd:cd00116 100 VLESLLRSSSLQELKLNNNGLgdRGLRLLAKGLKDLPPaLEKLVLGRNRLegaSCEALAkaLRanRDLKELNLANNGIGD 179

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383  190 ISSPSL-QGLTSLKRLVLDGnlLNNHGLGDK-------VFFNLVNLTELSLVRNSLTAAPV-----NLPGTN--LRKLYL 254
Cdd:cd00116 180 AGIRALaEGLKANCNLEVLD--LNNNGLTDEgasalaeTLASLKSLEVLNLGDNNLTDAGAaalasALLSPNisLLTLSL 257


                ....*
gi 7019383  255 QDNHI 259
Cdd:cd00116 258 SCNDI 262
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 107-327 6.93e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 57.75  E-value: 6.93e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383  107 KELHLQENNIR--TITYDSLSKI-------PYLEELHLDDN----SVSAVSIEEGAFRDSNYLRLLFLSRNHLS-TIPWG 172
Cdd:cd00116  21 KLLCLQVLRLEgnTLGEEAAKALasalrpqPSLKELCLSLNetgrIPRGLQSLLQGLTKGCGLQELDLSDNALGpDGCGV 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383  173 LPR-----TIEELRLDDNRISTISSPSLQ-GLTS----LKRLVLDGNLLNNHGLGD--KVFFNLVNLTELSLVRNSLT-- 238
Cdd:cd00116 101 LESllrssSLQELKLNNNGLGDRGLRLLAkGLKDlppaLEKLVLGRNRLEGASCEAlaKALRANRDLKELNLANNGIGda 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383  239 AAPVNLPG----TNLRKLYLQDNHINRVPPNA----FSYLRQLYRLDMSNNNLSNLP-QGIFDDLDNITQLILRNNPWYC 309
Cdd:cd00116 181 GIRALAEGlkanCNLEVLDLNNNGLTDEGASAlaetLASLKSLEVLNLGDNNLTDAGaAALASALLSPNISLLTLSLSCN 260

                       250
                ....*....|....*...
gi 7019383  310 GCKMKWVRDWLQSLPVKV 327
Cdd:cd00116 261 DITDDGAKDLAEVLAEKE 278
LRRCT smart00082
Leucine rich repeat C-terminal domain;
305-356 4.14e-08

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 49.74  E-value: 4.14e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 7019383     305 NPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGmAIKDLNAELFDCK 356
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKCP 51
LRR_8 pfam13855
Leucine rich repeat;
226-283 6.20e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 6.20e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7019383    226 NLTELSLVRNSLTA----APVNLPgtNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNL 283
Cdd:pfam13855   2 NLRSLDLSNNRLTSlddgAFKGLS--NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-284 6.48e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.01  E-value: 6.48e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383    75 IPSDLKNLLKVERIYLYHNSLDEfptNLPKyvkelhlqennirtitydSLSKIPYLEELHLDDNSVSAvSIEEGAFRDSN 154
Cdd:PLN00113 252 IPSSLGNLKNLQYLFLYQNKLSG---PIPP------------------SIFSLQKLISLDLSDNSLSG-EIPELVIQLQN 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383   155 yLRLLFLSRNHLS-TIPWG---LPRtIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNnhGLGDKVFFNLVNLTEL 230
Cdd:PLN00113 310 -LEILHLFSNNFTgKIPVAltsLPR-LQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLT--GEIPEGLCSSGNLFKL 385

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 7019383   231 SLVRNSLTAA-PVNLPGTN-LRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLS 284
Cdd:PLN00113 386 ILFSNSLEGEiPKSLGACRsLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQ 441
LRR_8 pfam13855
Leucine rich repeat;
175-237 1.40e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.40e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7019383    175 RTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNnhGLGDKVFFNLVNLTELSLVRNSL 237
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
128-211 2.05e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 2.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383    128 PYLEELHLDDNSVSavSIEEGAFRDSNYLRLLFLSRNHLSTIPWGlprtieelrlddnristisspSLQGLTSLKRLVLD 207
Cdd:pfam13855   1 PNLRSLDLSNNRLT--SLDDGAFKGLSNLKVLDLSNNLLTTLSPG---------------------AFSGLPSLRYLDLS 57


                  ....
gi 7019383    208 GNLL 211
Cdd:pfam13855  58 GNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 41-305 7.74e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.54  E-value: 7.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383    41 FIYCNdRFLTSIPTGI--PEDATTLYLQNNQINNAgIPSDLKNLLKVERIYLYHNSLD-EFP---TNLPKyVKELHLQEN 114
Cdd:PLN00113 266 FLYQN-KLSGPIPPSIfsLQKLISLDLSDNSLSGE-IPELVIQLQNLEILHLFSNNFTgKIPvalTSLPR-LQVLQLWSN 342

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383   115 NIRTITYDSLSKIPYLEELHLDDNSVSAvSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLP--RTIEELRLDDNRIS---- 188
Cdd:PLN00113 343 KFSGEIPKNLGKHNNLTVLDLSTNNLTG-EIPEGLCSSGNLFKLILFSNSLEGEIPKSLGacRSLRRVRLQDNSFSgelp 421

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383   189 ------------TISSPSLQG--------LTSLKRLVLDGNLLNNhGLGDkvFFNLVNLTELSLVRNSLTAAPVNLPGT- 247
Cdd:PLN00113 422 seftklplvyflDISNNNLQGrinsrkwdMPSLQMLSLARNKFFG-GLPD--SFGSKRLENLDLSRNQFSGAVPRKLGSl 498

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 7019383   248 -NLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNN 305
Cdd:PLN00113 499 sELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQN 557
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
140-305 1.17e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.62  E-value: 1.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383   140 VSAVSIEEGAFRDSNYLRL----------LFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSpSLQGltSLKRLVLDGN 209
Cdd:PRK15370 154 VKEAPAKEAANREEAVQRMrdclknnkteLRLKILGLTTIPACIPEQITTLILDNNELKSLPE-NLQG--NIKTLYANSN 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383   210 LLNN--HGLGDKVffnlvnlTELSLVRNSLTAAPVNLPgTNLRKLYLQDNHINRVPPNAFSYLRQlyrLDMSNNNLSNLP 287
Cdd:PRK15370 231 QLTSipATLPDTI-------QEMELSINRITELPERLP-SALQSLDLFHNKISCLPENLPEELRY---LSVYDNSIRTLP 299

                        170
                 ....*....|....*...
gi 7019383   288 QGIfddLDNITQLILRNN 305
Cdd:PRK15370 300 AHL---PSGITHLNVQSN 314
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 45-284 2.61e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.62  E-value: 2.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383    45 NDRFLTSIPT--GIPEDATTLYLQNNQINNAgIPSDLKNLLKVERIYLYHNSLD-EFPTNLP--KYVKELHLQENNIRTI 119
Cdd:PLN00113 341 SNKFSGEIPKnlGKHNNLTVLDLSTNNLTGE-IPEGLCSSGNLFKLILFSNSLEgEIPKSLGacRSLRRVRLQDNSFSGE 419

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383   120 TYDSLSKIPYLEELHLDDNSVSAvSIEEGAFrDSNYLRLLFLSRNHLSTipwGLP-----RTIEELRLDDNRISTISSPS 194
Cdd:PLN00113 420 LPSEFTKLPLVYFLDISNNNLQG-RINSRKW-DMPSLQMLSLARNKFFG---GLPdsfgsKRLENLDLSRNQFSGAVPRK 494

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383   195 LQGLTSLKRLVLDGNLLNNhglgdkvffnlVNLTELSLVRNsltaapvnlpgtnLRKLYLQDNHINRVPPNAFSYLRQLY 274
Cdd:PLN00113 495 LGSLSELMQLKLSENKLSG-----------EIPDELSSCKK-------------LVSLDLSHNQLSGQIPASFSEMPVLS 550

                        250
                 ....*....|
gi 7019383   275 RLDMSNNNLS 284
Cdd:PLN00113 551 QLDLSQNQLS 560
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 61-259 4.36e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.40  E-value: 4.36e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383   61 TTLYLQNNQINNAG---IPSDLKNLLKVERIYLYHNSLDE-----FPTNL--PKYVKELHLQENNIR----TITYDSLSK 126
Cdd:COG5238 239 TTLDLSNNQIGDEGviaLAEALKNNTTVETLYLSGNQIGAegaiaLAKALqgNTTLTSLDLSVNRIGdegaIALAEGLQG 318

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383  127 IPYLEELHLDDNSVSAvsieEGAfrdsnylRLLF--LSRNhlstipwglpRTIEELRLDDNRISTISSPSLqgltslkrl 204
Cdd:COG5238 319 NKTLHTLNLAYNGIGA----QGA-------IALAkaLQEN----------TTLHSLDLSDNQIGDEGAIAL--------- 368

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383  205 vldGNLLNNHGlgdkvffnlvNLTELSLVRNSLTAAPVN-----LPGTNLRKLYLQDNHI 259
Cdd:COG5238 369 ---AKYLEGNT----------TLRELNLGKNNIGKQGAEalidaLQTNRLHTLILDGNLI 415
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 45-305 4.62e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.85  E-value: 4.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383    45 NDRFLTSIPTGIPEDATTLYLQNNQINNAgIPSDLKNLLKVERIYLYHNSL-DEFP---TNLPKyVKELHLQENNIRTIT 120
Cdd:PLN00113 127 NNNFTGSIPRGSIPNLETLDLSNNMLSGE-IPNDIGSFSSLKVLDLGGNVLvGKIPnslTNLTS-LEFLTLASNQLVGQI 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383   121 YDSLSKIPYLEELHLDDNSVSA-VSIEEGAFRDSNYLRLLFlsrNHLS-TIPWGLP--RTIEELRLDDNRISTISSPSLQ 196
Cdd:PLN00113 205 PRELGQMKSLKWIYLGYNNLSGeIPYEIGGLTSLNHLDLVY---NNLTgPIPSSLGnlKNLQYLFLYQNKLSGPIPPSIF 281

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383   197 GLTSLKRLVLDGNLLNnhGLGDKVFFNLVNLTELSLVRNSLTA----APVNLPgtNLRKLYLQDNHINRVPPNAFSYLRQ 272
Cdd:PLN00113 282 SLQKLISLDLSDNSLS--GEIPELVIQLQNLEILHLFSNNFTGkipvALTSLP--RLQVLQLWSNKFSGEIPKNLGKHNN 357

                        250       260       270
                 ....*....|....*....|....*....|....
gi 7019383   273 LYRLDMSNNNLS-NLPQGIFDDlDNITQLILRNN 305
Cdd:PLN00113 358 LTVLDLSTNNLTgEIPEGLCSS-GNLFKLILFSN 390
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
49-306 7.33e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 49.39  E-value: 7.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383    49 LTSIPTGIPEDATTLYLQNNQINN-AGIPSDLKNLlkveriYLYHNSLDEFPTnLPKYVKELHLQENNIRT--------- 118
Cdd:PRK15387 213 LTTLPDCLPAHITTLVIPDNNLTSlPALPPELRTL------EVSGNQLTSLPV-LPPGLLELSIFSNPLTHlpalpsglc 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383   119 ---ITYDSLSKIPY----LEELHLDDNSVSAVSIEegafrdSNYLRLLFLSRNHLSTIPwGLPRTIEELRLDDNRISTIs 191
Cdd:PRK15387 286 klwIFGNQLTSLPVlppgLQELSVSDNQLASLPAL------PSELCKLWAYNNQLTSLP-TLPSGLQELSVSDNQLASL- 357

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383   192 sPSLQglTSLKRLVLDGNLLNNHGLGDKvffnlvNLTELSLVRNSLTAAPVnLPgTNLRKLYLQDNHINRVP--PNAfsy 269
Cdd:PRK15387 358 -PTLP--SELYKLWAYNNRLTSLPALPS------GLKELIVSGNRLTSLPV-LP-SELKELMVSGNRLTSLPmlPSG--- 423

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 7019383   270 lrqLYRLDMSNNNLSNLPQGIFdDLDNITQLILRNNP 306
Cdd:PRK15387 424 ---LLSLSVYRNQLTRLPESLI-HLSSETTVNLEGNP 456
LRR_8 pfam13855
Leucine rich repeat;
106-166 2.82e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 2.82e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 7019383    106 VKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSavSIEEGAFRDSNYLRLLFLSRNHL 166
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
31-61 6.78e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 40.38  E-value: 6.78e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 7019383      31 CPSVCRCDAGFIYCNDRFLTSIPTGIPEDAT 61
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 226-305 2.02e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 2.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383  226 NLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPpnAFSYLRQLYRLDMSNNNLSNLPQgiFDDLDNITQLILRNN 305
Cdd:cd21340   3 RITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGN 78
fn3 pfam00041
Fibronectin type III domain;
413-478 5.97e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.94  E-value: 5.97e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019383    413 ITVKSVTSDTIHISWKLAL----PMTALRLSWLKLGHSpafGSITETIVTGERSEYLVTALEPDSPYKVC 478
Cdd:pfam00041   6 LTVTDVTSTSLTVSWTPPPdgngPITGYEVEYRPKNSG---EPWNEITVPGTTTSVTLTGLKPGTEYEVR 72
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 31-57 1.85e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 36.07  E-value: 1.85e-03
                          10        20
                  ....*....|....*....|....*..
gi 7019383     31 CPSVCRCDAGFIYCNDRFLTSIPTGIP 57
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRR_8 pfam13855
Leucine rich repeat;
84-138 3.26e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 3.26e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 7019383     84 KVERIYLYHNSL----DEFPTNLPKyVKELHLQENNIRTITYDSLSKIPYLEELHLDDN 138
Cdd:pfam13855   2 NLRSLDLSNNRLtsldDGAFKGLSN-LKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 247-283 3.27e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 3.27e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 7019383    247 TNLRKLYLQDNHINRVPPnaFSYLRQLYRLDMSNNNL 283
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNK 35
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 413-477 3.66e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 36.82  E-value: 3.66e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7019383     413 ITVKSVTSDTIHISWKLALP--MTALRLSWlKLGHSPAFGSITETIVTGERSEYLVTALEPDSPYKV 477
Cdd:smart00060   7 LRVTDVTSTSVTLSWEPPPDdgITGYIVGY-RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH