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Conserved domains on  [gi|1844083993|ref|NP_037434|]
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eukaryotic elongation factor 2 kinase [Homo sapiens]

Protein Classification

Alpha_kinase_eEF2K and TPR domain-containing protein( domain architecture ID 13015117)

Alpha_kinase_eEF2K and TPR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Alpha_kinase_eEF2K cd16967
Alpha-kinase domain of eukaryotic elongation factor-2 kinase; Eukaryotic elongation factor-2 ...
 103-318 3.46e-165

Alpha-kinase domain of eukaryotic elongation factor-2 kinase; Eukaryotic elongation factor-2 kinase (eEF2K) is also called calcium/calmodulin (CaM)-dependent eEF2K. It phosphorylates eukaryotic elongation factor-2 (EEF2) at a single site, leading to its inactivation and inability to bind ribosomes, and slowing down the elongation stage of protein synthesis. It has been linked to many human diseases including cardiovascular conditions (atherosclerosis) and pulmonary arterial hypertension, as well as solid tumors and neurological disorders. eEF2K is an atypical protein kinase containing a CaM binding region, an alpha-kinase catalytic domain, and TPR-like Sel1 repeats at the C-terminus. Alpha-kinase is an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


:

Pssm-ID: 341217  Cd Length: 216  Bit Score: 473.74  E-value: 3.46e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 103 HLEDIATERATRHRYNAVTGEWLDDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDRDVYF 182
Cdd:cd16967     1 HLEDLPTERAVRHRYNAATKKWTKDEVLVKMESKPFARGAMRECYRAKKLSNFSHNQDWKHASNYVAKRYIEPVDREVYF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 183 EDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKDRPGKPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLTPQAFSHFT 262
Cdd:cd16967    81 EDVRLQMDAKLWGEEYNRHNPPKKVDIMQMCVLEFVDRPGSPLYHLEHFIEGDYIKYNSNSGFVRDDDIRLTPQAFSHFT 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1844083993 263 FERSGHQLIVVDIQGVGDLYTDPQIHTETGTDFGDGNLGVRGMALFFYSHACNRIC 318
Cdd:cd16967   161 FERSGHQLIVVDIQGVGDLYTDPQIHTADGEGYGDGNLGLRGMALFFHSHRCNPIC 216
TPR COG0790
TPR repeat [General function prediction only];
532-695 5.19e-12

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 66.49  E-value: 5.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 532 RYHEGGRFCEKgeewDQESAVFHLEHAANLGELEAIVGLGLMYSQLphhiladvslKETEENKTKGFDYLLKAAEAGDRQ 611
Cdd:COG0790   107 LMYEEGLGVPQ----DYAKALEWYEKAAEQGDADAQYNLGLLYLNG----------EGVPKDPAKAAEWYRKAAEQGDAD 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 612 SMILVARAFDSGQNLSpdrcQDWLEALHWYNTALEMtdcdegGEYDGMqdepryMMLAReaemLFTGGYGLEKDPQRSGD 691
Cdd:COG0790   173 AQYNLGVLYENGRGVP----KDPAKALEWYRKAAEQ------GDADAQ------YNLGR----LYLNGEGVEKDLEKALR 232


                  ....
gi 1844083993 692 LYTQ 695
Cdd:COG0790   233 WLRK 236
 
Name Accession Description Interval E-value
Alpha_kinase_eEF2K cd16967
Alpha-kinase domain of eukaryotic elongation factor-2 kinase; Eukaryotic elongation factor-2 ...
 103-318 3.46e-165

Alpha-kinase domain of eukaryotic elongation factor-2 kinase; Eukaryotic elongation factor-2 kinase (eEF2K) is also called calcium/calmodulin (CaM)-dependent eEF2K. It phosphorylates eukaryotic elongation factor-2 (EEF2) at a single site, leading to its inactivation and inability to bind ribosomes, and slowing down the elongation stage of protein synthesis. It has been linked to many human diseases including cardiovascular conditions (atherosclerosis) and pulmonary arterial hypertension, as well as solid tumors and neurological disorders. eEF2K is an atypical protein kinase containing a CaM binding region, an alpha-kinase catalytic domain, and TPR-like Sel1 repeats at the C-terminus. Alpha-kinase is an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341217  Cd Length: 216  Bit Score: 473.74  E-value: 3.46e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 103 HLEDIATERATRHRYNAVTGEWLDDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDRDVYF 182
Cdd:cd16967     1 HLEDLPTERAVRHRYNAATKKWTKDEVLVKMESKPFARGAMRECYRAKKLSNFSHNQDWKHASNYVAKRYIEPVDREVYF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 183 EDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKDRPGKPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLTPQAFSHFT 262
Cdd:cd16967    81 EDVRLQMDAKLWGEEYNRHNPPKKVDIMQMCVLEFVDRPGSPLYHLEHFIEGDYIKYNSNSGFVRDDDIRLTPQAFSHFT 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1844083993 263 FERSGHQLIVVDIQGVGDLYTDPQIHTETGTDFGDGNLGVRGMALFFYSHACNRIC 318
Cdd:cd16967   161 FERSGHQLIVVDIQGVGDLYTDPQIHTADGEGYGDGNLGLRGMALFFHSHRCNPIC 216
Alpha_kinase smart00811
Alpha-kinase family; This family is a novel family of eukaryotic protein kinase catalytic ...
 121-318 1.42e-98

Alpha-kinase family; This family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional kinases. The family contains myosin heavy chain kinases and Elongation Factor-2 kinase and a bifunctional ion channel. This family is known as the alpha-kinase family. The structure of the kinase domain revealed unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains.


Pssm-ID: 214828  Cd Length: 198  Bit Score: 301.97  E-value: 1.42e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993  121 TGEWLDDEVLIKMASQPFGRGAMRECFRTKKLSNFLHaqQWKGASNYVAKRYIEPVdRDVYFEDVRLQMEAKLWGEEYNR 200
Cdd:smart00811   2 SGKWTVSETGVKIELKPFAKGAMRVAFRVKDLSEDGS--GTECVAKYFKKEYKNTV-EDRYFEDVEMQMVAKKFAEEFNQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993  201 HKP-PKQVDIMQMCIIELKDRPGKPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLT-PQAFSHFTFERSGHQLIVVDIQGV 278
Cdd:smart00811  79 LKPsPKKIEFLPSYVLELPDRSIPYLFTVEPFLEGEFVKYNSNNGWVNDEARSTEaPQAFSHFTYERSGGSLLVVDLQGV 158

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1844083993  279 GDLYTDPQIHTETGTDFGDGNLGVRGMALFFYSHACNRIC 318
Cdd:smart00811 159 GDLLTDPQIHTEDGFGFGPGNLGEEGIEKFFATHKCNSIC 198
Alpha_kinase pfam02816
Alpha-kinase family; This family is a novel family of eukaryotic protein kinase catalytic ...
 139-318 1.99e-73

Alpha-kinase family; This family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional kinases. The family contains myosin heavy chain kinases and Elongation Factor-2 kinase and a bifunctional ion channel. This family is known as the alpha-kinase family. The structure of the kinase domain revealed unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains.


Pssm-ID: 460709  Cd Length: 185  Bit Score: 235.69  E-value: 1.99e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 139 GRGAMRECFRTKKLSnflhaqQWKGASNYVAKRYIEPV---DRDVYFEDVRLQMEAKLWGEEYN------RHKPPKQVDI 209
Cdd:pfam02816   1 AEGAMRKAFKAKVDP------GDESGQNYVAKEFKKIVygvELEYYFEDAQSQALAKELAEEFNaearalENFPPKKIEF 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 210 MQMCIIELKDRPGKPLFHLEHYIEGKYIKYNSNSGFVRDDN--IRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQI 287
Cdd:pfam02816  75 IPPYVVELDPANGKPYYLVEPFLEGNFVKYNSNTGFVSEEDdeLEQTMQAFSHFTYERSGGQLLVCDLQGVGNLLTDPAI 154

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1844083993 288 HTETGTDFGDGNLGVRGMALFFYSHACNRIC 318
Cdd:pfam02816 155 HTKDGKRFGDTNLGEEGIASFFSTHKCNKIC 185
TPR COG0790
TPR repeat [General function prediction only];
532-695 5.19e-12

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 66.49  E-value: 5.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 532 RYHEGGRFCEKgeewDQESAVFHLEHAANLGELEAIVGLGLMYSQLphhiladvslKETEENKTKGFDYLLKAAEAGDRQ 611
Cdd:COG0790   107 LMYEEGLGVPQ----DYAKALEWYEKAAEQGDADAQYNLGLLYLNG----------EGVPKDPAKAAEWYRKAAEQGDAD 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 612 SMILVARAFDSGQNLSpdrcQDWLEALHWYNTALEMtdcdegGEYDGMqdepryMMLAReaemLFTGGYGLEKDPQRSGD 691
Cdd:COG0790   173 AQYNLGVLYENGRGVP----KDPAKALEWYRKAAEQ------GDADAQ------YNLGR----LYLNGEGVEKDLEKALR 232


                  ....
gi 1844083993 692 LYTQ 695
Cdd:COG0790   233 WLRK 236
 
Name Accession Description Interval E-value
Alpha_kinase_eEF2K cd16967
Alpha-kinase domain of eukaryotic elongation factor-2 kinase; Eukaryotic elongation factor-2 ...
 103-318 3.46e-165

Alpha-kinase domain of eukaryotic elongation factor-2 kinase; Eukaryotic elongation factor-2 kinase (eEF2K) is also called calcium/calmodulin (CaM)-dependent eEF2K. It phosphorylates eukaryotic elongation factor-2 (EEF2) at a single site, leading to its inactivation and inability to bind ribosomes, and slowing down the elongation stage of protein synthesis. It has been linked to many human diseases including cardiovascular conditions (atherosclerosis) and pulmonary arterial hypertension, as well as solid tumors and neurological disorders. eEF2K is an atypical protein kinase containing a CaM binding region, an alpha-kinase catalytic domain, and TPR-like Sel1 repeats at the C-terminus. Alpha-kinase is an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341217  Cd Length: 216  Bit Score: 473.74  E-value: 3.46e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 103 HLEDIATERATRHRYNAVTGEWLDDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDRDVYF 182
Cdd:cd16967     1 HLEDLPTERAVRHRYNAATKKWTKDEVLVKMESKPFARGAMRECYRAKKLSNFSHNQDWKHASNYVAKRYIEPVDREVYF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 183 EDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKDRPGKPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLTPQAFSHFT 262
Cdd:cd16967    81 EDVRLQMDAKLWGEEYNRHNPPKKVDIMQMCVLEFVDRPGSPLYHLEHFIEGDYIKYNSNSGFVRDDDIRLTPQAFSHFT 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1844083993 263 FERSGHQLIVVDIQGVGDLYTDPQIHTETGTDFGDGNLGVRGMALFFYSHACNRIC 318
Cdd:cd16967   161 FERSGHQLIVVDIQGVGDLYTDPQIHTADGEGYGDGNLGLRGMALFFHSHRCNPIC 216
Alpha_kinase smart00811
Alpha-kinase family; This family is a novel family of eukaryotic protein kinase catalytic ...
 121-318 1.42e-98

Alpha-kinase family; This family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional kinases. The family contains myosin heavy chain kinases and Elongation Factor-2 kinase and a bifunctional ion channel. This family is known as the alpha-kinase family. The structure of the kinase domain revealed unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains.


Pssm-ID: 214828  Cd Length: 198  Bit Score: 301.97  E-value: 1.42e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993  121 TGEWLDDEVLIKMASQPFGRGAMRECFRTKKLSNFLHaqQWKGASNYVAKRYIEPVdRDVYFEDVRLQMEAKLWGEEYNR 200
Cdd:smart00811   2 SGKWTVSETGVKIELKPFAKGAMRVAFRVKDLSEDGS--GTECVAKYFKKEYKNTV-EDRYFEDVEMQMVAKKFAEEFNQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993  201 HKP-PKQVDIMQMCIIELKDRPGKPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLT-PQAFSHFTFERSGHQLIVVDIQGV 278
Cdd:smart00811  79 LKPsPKKIEFLPSYVLELPDRSIPYLFTVEPFLEGEFVKYNSNNGWVNDEARSTEaPQAFSHFTYERSGGSLLVVDLQGV 158

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1844083993  279 GDLYTDPQIHTETGTDFGDGNLGVRGMALFFYSHACNRIC 318
Cdd:smart00811 159 GDLLTDPQIHTEDGFGFGPGNLGEEGIEKFFATHKCNSIC 198
Alpha_kinase_MHCK_like cd16968
Alpha-kinase domain of myosin heavy chain kinase and similar domains; This group is composed ...
 111-318 1.06e-95

Alpha-kinase domain of myosin heavy chain kinase and similar domains; This group is composed of alpha-kinase domains of Dictyostelium discoideum myosin heavy chain kinases A-D (MHCKA, MHCKB, MHCKC, MHCKD), alpha-protein kinase 1 (AK1), and similar proteins. The myosin heavy chain kinases are involved in regulating myosin II filament assembly in Dictyostelium discoideum. They phosphorylate target threonine residues located in the carboxyl-terminal portion of the myosin II heavy chain (MHC) tail, resulting in filament disassembly. The different MHCK isoforms display different spatial regulation, indicating specific roles for each isoform in fine tuning the Dictyostelium actomyosin cytoskeleton. They all contain an alpha-kinase domain as well as WD40 repeats at the C-terminus. AK1 contains an N-terminal Arf-GAP domain and a central alpha-kinase domain. Alpha-kinase is an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341218  Cd Length: 202  Bit Score: 294.91  E-value: 1.06e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 111 RATRHRYNAVTGEWLDDEVLIKMASQPFGRGAMRECFRTKKLSNFlhaqqwKGASNYVAKRYIEP-VDRDVYFEDVRLQM 189
Cdd:cd16968     1 RAIKHEFDPETGKWTSTATKVKIDPKPFAEGALREAYHLKDLSAP------GPSTLFVAKLSKDPnESRETYFEDVEMQM 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 190 EAKLWGEEYNRHKPPKQVDIMQMCIIELKDRPGKPLFHLEHYIEGKYIKYNSNSGFVRDDNiRLTPQAFSHFTFERSGHQ 269
Cdd:cd16968    75 VCKKWAEKFNAKNPPKKVEFLPAWVLELVDRPPPPLCGVEPFIEGEYVKHNNNFGYVDEDE-RNTPQAFSHFTYEASGHQ 153

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1844083993 270 LIVVDIQGVGDLYTDPQIHTETGTDFGDGNLGVRGMALFFYSHACNRIC 318
Cdd:cd16968   154 LLVVDIQGVGDLYTDPQIHTIDGKGFGKGNLGQKGIEKFLETHKCNAIC 202
Alpha_kinase pfam02816
Alpha-kinase family; This family is a novel family of eukaryotic protein kinase catalytic ...
 139-318 1.99e-73

Alpha-kinase family; This family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional kinases. The family contains myosin heavy chain kinases and Elongation Factor-2 kinase and a bifunctional ion channel. This family is known as the alpha-kinase family. The structure of the kinase domain revealed unexpected similarity to eukaryotic protein kinases in the catalytic core as well as to metabolic enzymes with ATP-grasp domains.


Pssm-ID: 460709  Cd Length: 185  Bit Score: 235.69  E-value: 1.99e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 139 GRGAMRECFRTKKLSnflhaqQWKGASNYVAKRYIEPV---DRDVYFEDVRLQMEAKLWGEEYN------RHKPPKQVDI 209
Cdd:pfam02816   1 AEGAMRKAFKAKVDP------GDESGQNYVAKEFKKIVygvELEYYFEDAQSQALAKELAEEFNaearalENFPPKKIEF 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 210 MQMCIIELKDRPGKPLFHLEHYIEGKYIKYNSNSGFVRDDN--IRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQI 287
Cdd:pfam02816  75 IPPYVVELDPANGKPYYLVEPFLEGNFVKYNSNTGFVSEEDdeLEQTMQAFSHFTYERSGGQLLVCDLQGVGNLLTDPAI 154

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1844083993 288 HTETGTDFGDGNLGVRGMALFFYSHACNRIC 318
Cdd:pfam02816 155 HTKDGKRFGDTNLGEEGIASFFSTHKCNKIC 185
Alpha_kinase cd04515
Alpha kinase family; The alpha kinase family is a novel family of eukaryotic protein kinase ...
 121-318 4.52e-69

Alpha kinase family; The alpha kinase family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional serine/threonine protein kinases. The family contains myosin heavy chain kinases, elongation factor-2 kinases, and bifunctional ion channel kinases. These kinases are implicated in a large variety of cellular processes such as protein translation, Mg2+/Ca2+ homeostasis, intracellular transport, cell migration, adhesion, and proliferation. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341214  Cd Length: 213  Bit Score: 225.36  E-value: 4.52e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 121 TGEWLDDEVLIKMASQ-PFGRGAMRECFRTKKLSNFlhaqqwkgASNYVAKRYIEPVDRDV----YFEDVRLQMEAKLWG 195
Cdd:cd04515    12 DLKWTTEETTVRVAKKkPFAQGAMREAFKAKDLDSK--------GKKYVAKRFKRIGDPEEnledLFDELRMQALAQYLA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 196 EEYNRHK-----PPKQVDIMQMCIIELKDR--PGKPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLTPQAFSHFTFERSGH 268
Cdd:cd04515    84 KEFNARAksknlIAPKINFVDPFVVKLGDRddPGKVVFLVEPFLEGKFVKYNNNNGMVNDEDLGETAQAFSHFTYERSGG 163

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1844083993 269 QLIVVDIQGVGDLYTDPQIHTETGTDFGDGNLGVRGMALFFYSHACNRIC 318
Cdd:cd04515   164 QLLVTDLQGVGLVLTDPQIHTVDGGGFGLGNLGEEGIKRFFKTHKCNEIC 213
Alpha_kinase_VwkA_like cd16970
Alpha-kinase domain of Dictyostelium discoideum VwkA and similar domains; Dictyostelium ...
 131-318 6.55e-37

Alpha-kinase domain of Dictyostelium discoideum VwkA and similar domains; Dictyostelium discoideum alpha-protein kinase VwkA is also called von Willebrand factor A alpha-kinase or vWF kinase. It influences myosin II abundance and assembly behavior as vWKA gene disruption leads to significant myosin II overassembly. VwkA also serves a critical conserved role in the periodic contractions of the contractile vacuole through its regulation of the myosin II cortical cytoskeleton. It contains a vWFa domain (named after its homology to von Willebrand factor A, a plasma glycoprotein essential for proper blood clotting) and a C-terminal alpha-kinase domain. Alpha-kinase is an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341220  Cd Length: 227  Bit Score: 138.24  E-value: 6.55e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 131 IKMASQPFGRGAMRECFRTKKLSNFLHaqqwkgaSNYVAKRYIEPVD-----RDVYFEDVRLQ-MEAKLwGEEYN----R 200
Cdd:cd16970    34 VKIAPPPFAKGAERWAYYALDTTSDST-------KKVVLKEFKTPGSaqrnsRERYLESMEVQtVAAKL-AFEFNkllaR 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 201 HKPPKQVDIMQMCIIELKDRPGKPLFHLEHYIEGKYIKYNSNSGFVRDDNiRLTPQAFSHFTFERSGHQLIVVDIQGV-- 278
Cdd:cd16970   106 AGINKKITFLEAKVLRVANGDSPQYYTMESFLEGEYKKFNNNVGVVNEDE-VEILQAFSHWTYEASKGYLMVVDLQGVrt 184

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1844083993 279 ---GDLYTDPQIHTETGTDFGDGNLGVRGMALFFYSHACNRIC 318
Cdd:cd16970   185 dddGFLLTDPAIHCTDVLRFGRTNLGKEGIDKFFATHKCNQHC 227
Alpha_kinase cd17508
Alpha kinase family; uncharacterized subgroup; The alpha kinase family is a novel family of ...
 128-318 6.44e-32

Alpha kinase family; uncharacterized subgroup; The alpha kinase family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional serine/threonine protein kinases. The family contains myosin heavy chain kinases, elongation factor-2 kinases, and bifunctional ion channel kinases. These kinases are implicated in a large variety of cellular processes such as protein translation, Mg2+/Ca2+ homeostasis, intracellular transport, cell migration, adhesion, and proliferation. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341225  Cd Length: 243  Bit Score: 124.42  E-value: 6.44e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 128 EVLIKMASQPFGRGAMRECFRTKKLSN--FLHAQQWKGASnYVAK--RYIEPVDRDVYFED--VRLQMEAKLWGEEYNR- 200
Cdd:cd17508    16 AFGIAVRKLPFGEGAERNVFRCTEISKegGTKTATKIGPR-LVAKesRHAEDESFDIKFHKkfCKTQSTAQELAERFNKr 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 201 -----HKPPKQVDIMQMCIIELKD--RPGKPLFHLEHYIEGKYIKYNSNSGFVR------------DDNIRLT----PQA 257
Cdd:cd17508    95 lralpGGPAPRVKFLPCHVYKTKDvsYRGRAWVLVEKELEGKFTKWNTNAGGVKksiesvgegrgeSNSSRLRvddvPQA 174

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1844083993 258 FSHFTFERSGHQLIVVDIQGV------GDLYTDPQIHTETGT--DFGDGNLGVRGMALFFYSHACNRIC 318
Cdd:cd17508   175 FSHFTYEHSGGRFLVCDLQGVwnatpdGFLLTDPVIHHVSGKrhRFGATDKGLEGIRNFLRTHKCSPLC 243
Alpha_kinase_ALPK1 cd16969
Alpha-kinase domain of alpha-protein kinase 1; Alpha-protein kinase 1 is also called ...
 116-318 2.04e-24

Alpha-kinase domain of alpha-protein kinase 1; Alpha-protein kinase 1 is also called chromosome 4 kinase or lymphocyte alpha-protein kinase (LAK). ALPK1 is implicated in epithelial cell polarity and exocytic vesicular transport towards the apical plasma membrane. It resides on Golgi-derived vesicles where it phosphorylates myosin IA, a motor protein that regulates the delivery of vesicles to the plasma-membrane. It may be associated with inflammation-related diseases such as gout and type 2 diabetes mellitus. ALPK1 contains a C-terminal alpha-kinase domain, an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341219  Cd Length: 227  Bit Score: 102.16  E-value: 2.04e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 116 RYNAVTGEWLDDEVLI------KMASQpfgrGAMRECFRTKklsnFLHaqQWKGASNYVAKRYIEPVDRDVYFEDVRLQM 189
Cdd:cd16969    14 KYSKKSGLWTAQETMVyigdnlQVGKQ----GKQRNAFWVH----FLH--QEETLGRYVGKEYKKPKELQYHFNDVERQM 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 190 EAKLWGEEYNR----HKPPKQVDIMQMCIIE-LKDRPGKPLFHLEHYIEGKYIKYNSNSGFVRDDNiRLTPQ--AFSHFT 262
Cdd:cd16969    84 TAQHYVTEFNKrlyeQNIPTQIFFIPSVILLiLEDKGIKGCVSVEPYMLGEFVKLTNNTTVKKEEY-KATDYglAYGHFT 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1844083993 263 FERSGHQLIVVDIQG------VGDLY-TDPQIHTETGTdFGDGNLGVRGMALFFYSH--ACNRIC 318
Cdd:cd16969   163 YEFSNHQDVVVDLQGwvtangKGLTYlTDPQIHSVVKK-SGTTNFGKKGIEYFFNNQhtECNEIC 226
Alpha_kinase cd17509
Alpha kinase family; uncharacterized subgroup; The alpha kinase family is a novel family of ...
 229-318 1.26e-16

Alpha kinase family; uncharacterized subgroup; The alpha kinase family is a novel family of eukaryotic protein kinase catalytic domains, which have no detectable similarity to conventional serine/threonine protein kinases. The family contains myosin heavy chain kinases, elongation factor-2 kinases, and bifunctional ion channel kinases. These kinases are implicated in a large variety of cellular processes such as protein translation, Mg2+/Ca2+ homeostasis, intracellular transport, cell migration, adhesion, and proliferation. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341226  Cd Length: 221  Bit Score: 79.31  E-value: 1.26e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 229 EHYIEGkYIKYNSNSG-FVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGD----LYTDPQIHTETGTDFGDGNLGVR 303
Cdd:cd17509   128 EPFIEN-YEKFNSNSGwNDDSKGWGEVMQALSHFSYHISGGKYLLCDLQGGVYkneyVLTDPVILSRTGREYGVTDLGPE 206

                          90
                  ....*....|....*
gi 1844083993 304 GMALFFYSHACNRIC 318
Cdd:cd17509   207 GIWNFFANHKCNKYC 221
Alpha_kinase_ChaK2_TRPM6 cd16972
Alpha-kinase domain of channel kinase 2, also called transient receptor potential cation ...
 228-318 2.75e-14

Alpha-kinase domain of channel kinase 2, also called transient receptor potential cation channel subfamily M member 6; Channel kinase 2 (ChaK2), also called transient receptor potential cation channel subfamily M member 6 (TRMP6) or melastatin-related TRP cation channel 6, is a fusion protein containing a transmembrane ion pore or channel and a C-terminal alpha-kinase domain, both of which are functional. It is highly expressed in the kidney and instestine. It is a cation-selective channel that preferentially permeates Zn2+, Mg2+, and Ca2+ ions. It is a central regulator of Mg2+ and Ca2+ homeostasis. TRPM6 is considered to be the Mg2+ entry pathway in the distal convoluted tubule of the kidney, where it functions as a gatekeeper for controlling the body's Mg2+ balance. Mutations in the TRPM6 gene cause the autosomal recessive disorder hypomagnesemia with secondary hypocalcemia, which often results in severe muscular and neurologic complications from early infancy that can lead to neurologic damage or cardiac arrest if left untreated. Alpha-kinase is an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341222  Cd Length: 239  Bit Score: 73.11  E-value: 2.75e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 228 LEHYIEGKYIKYNSNSGfvrdDNIrlTPQ--------AFSHFTFERSGHQLIVVDIQGVGDLYTDPQI-----HTETGTD 294
Cdd:cd16972   140 IEKYLTGEFRKYNNNNG----DEI--TPTslleetllAFSHWTYEYTRGELLVLDLQGVGENLTDPSVikpedKQSRGMV 213

                          90       100
                  ....*....|....*....|....
gi 1844083993 295 FGDGNLGVRGMALFFYSHACNRIC 318
Cdd:cd16972   214 FGPANLGEDAIRNFIAKHHCNSCC 237
Alpha_kinase_ChaK cd16965
Alpha-kinase domain of channel kinases; This group is composed of channel kinases 1 (ChaK1) ...
 226-318 1.02e-12

Alpha-kinase domain of channel kinases; This group is composed of channel kinases 1 (ChaK1) and 2 (ChaK2), and similar proteins. ChaK1 and ChaK2 are also called transient receptor potential cation channel subfamily M members 7 (TRMP7) and 6 (TRMP6), respectively. They are fusion proteins containing a transmembrane ion pore or channel and a C-terminal alpha-kinase domain, both of which are functional. They are both cation-selective channels that preferentially permeate Zn2+, Mg2+, and Ca2+ ions. They are central regulators of Mg2+ and Ca2+ homeostasis. TRMP7 is ubiquitously expressed while TRMP6 is highly expressed in specific tissues such as the kidney and intestine. Alpha-kinase is an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341215  Cd Length: 239  Bit Score: 68.44  E-value: 1.02e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 226 FHLEHYIEGKYIKYNSNSG--FVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQI-----HTETGTDFGDG 298
Cdd:cd16965   138 LTVENNMTGEFRKYNNNNGdeILPTNTLEETMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVikvedKSSGEMVFGPA 217

                          90       100
                  ....*....|....*....|
gi 1844083993 299 NLGVRGMALFFYSHACNRIC 318
Cdd:cd16965   218 NLGEDAIQNFVAKHHCNSCC 237
Alpha_kinase_ChaK1_TRMP7 cd16971
Alpha-kinase domain of channel kinase 1, also called transient receptor potential cation ...
 226-318 1.58e-12

Alpha-kinase domain of channel kinase 1, also called transient receptor potential cation channel subfamily M member 7; Channel kinase 1 (ChaK1), also called transient receptor potential cation channel subfamily M member 7 (TRMP7) or long transient receptor potential channel 7 (LTrpC7), is a fusion protein containing a transmembrane ion pore or channel and a C-terminal alpha-kinase domain, both of which are functional. It is ubiquitously expressed and is a cation-selective channel that preferentially permeates Zn2+, Mg2+, and Ca2+ ions. It is a central regulator of Mg2+ and Ca2+ homeostasis. TRPM7 plays a role in cancer proliferation, stroke, hydrogen peroxide dependent neurodegeneration, and heavy metal toxicity. Alpha-kinase is an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341221  Cd Length: 239  Bit Score: 67.72  E-value: 1.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 226 FHLEHYIEGKYIKYNSNSG--FVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQI--HTETGTD---FGDG 298
Cdd:cd16971   138 FAVEECMTGEFRKYNNNNGdeIIPTNMLEETMLAFSHWTYEYTRGELLVLDLQGVGENLTDPSVikAGEKRSYdmvFGPA 217

                          90       100
                  ....*....|....*....|
gi 1844083993 299 NLGVRGMALFFYSHACNRIC 318
Cdd:cd16971   218 NLGEDAIKNFRAKHHCNSCC 237
TPR COG0790
TPR repeat [General function prediction only];
532-695 5.19e-12

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 66.49  E-value: 5.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 532 RYHEGGRFCEKgeewDQESAVFHLEHAANLGELEAIVGLGLMYSQLphhiladvslKETEENKTKGFDYLLKAAEAGDRQ 611
Cdd:COG0790   107 LMYEEGLGVPQ----DYAKALEWYEKAAEQGDADAQYNLGLLYLNG----------EGVPKDPAKAAEWYRKAAEQGDAD 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 612 SMILVARAFDSGQNLSpdrcQDWLEALHWYNTALEMtdcdegGEYDGMqdepryMMLAReaemLFTGGYGLEKDPQRSGD 691
Cdd:COG0790   173 AQYNLGVLYENGRGVP----KDPAKALEWYRKAAEQ------GDADAQ------YNLGR----LYLNGEGVEKDLEKALR 232


                  ....
gi 1844083993 692 LYTQ 695
Cdd:COG0790   233 WLRK 236
TPR COG0790
TPR repeat [General function prediction only];
533-695 2.64e-11

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 64.18  E-value: 2.64e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 533 YHEGgrfceKGEEWDQESAVFHLEHAANLGELEAIVGLGLMYSQLphhiladvslKETEENKTKGFDYLLKAAEAGDRQS 612
Cdd:COG0790    73 YAEG-----RGVPKDYEKALEWFEKAAEQGDAEAQYNLGLMYEEG----------LGVPQDYAKALEWYEKAAEQGDADA 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 613 MILVARAFDSGQNLSpdrcQDWLEALHWYNTALEmtdcdeGGEYDGMqdepryMMLAReaeMLFTGgYGLEKDPQRSGDL 692
Cdd:COG0790   138 QYNLGLLYLNGEGVP----KDPAKAAEWYRKAAE------QGDADAQ------YNLGV---LYENG-RGVPKDPAKALEW 197


                  ...
gi 1844083993 693 YTQ 695
Cdd:COG0790   198 YRK 200
TPR COG0790
TPR repeat [General function prediction only];
541-695 1.31e-05

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 47.23  E-value: 1.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 541 EKGEEWDQESAVFHLEHAANLGELEAIVGLGLMYSQLphhiladvslKETEENKTKGFDYLLKAAEAGDRQSMILVARAF 620
Cdd:COG0790    40 ALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEG----------RGVPKDYEKALEWFEKAAEQGDAEAQYNLGLMY 109

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1844083993 621 DSGQNLSpdrcQDWLEALHWYNTALemtdcdEGGEYDGMqdeprYMMlareAEMLFTgGYGLEKDPQRSGDLYTQ 695
Cdd:COG0790   110 EEGLGVP----QDYAKALEWYEKAA------EQGDADAQ-----YNL----GLLYLN-GEGVPKDPAKAAEWYRK 164
Alpha_kinase_ALPK2 cd16974
Alpha-kinase domain of alpha-protein kinase 2; Alpha-protein kinase 2 (ALPK2) is also called ...
 138-318 2.87e-05

Alpha-kinase domain of alpha-protein kinase 2; Alpha-protein kinase 2 (ALPK2) is also called heart alpha-protein kinase (HAK). Little functional information is known about ALPK2. In a three-dimensional colonic-crypt model, it has been identified as crucial for luminal apoptosis and expression of DNA repair-related genes, possibly in the transition of normal colonic crypt to adenoma. The ALPK2 gene may also be a novel candidate gene for inherited hypertension in Dahl rats. ALPK2 contains a C-terminal alpha-kinase domain and two immunoglobulin (Ig)-like domains. Alpha-kinase is an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341224  Cd Length: 239  Bit Score: 45.97  E-value: 2.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 138 FGRGAMRECFRTKKLSNFL------HAQQWK--GASNYVAKRYIEPVDRD--VYFEDVRLQMEAKLWGEEYNRHKPPKQV 207
Cdd:cd16974    39 FGEGMHRKAFRSKVMCGLLpvflpgHACVLKvhNAIAYGTKNNDELIQKNykLAVQECYVQNTAREYAKIYAAEAQPLEG 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 208 --DIMQMCIIELKDRPGK--PLFHLEHYIEGKYIKYNSNSG-----FVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGV 278
Cdd:cd16974   119 fgEVPEIIPIFLIHRPANniPYATVEEELIGDFVKYSVRDGkeinvLRRDSEAGQKCCTFQHWVYQKTDGNLLVTDMQGV 198

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1844083993 279 GDLYTDPQIHT-ETGTDFGDGNLGVRGMALFFYSHACNRIC 318
Cdd:cd16974   199 GMKLTDVGIATcSKGYKGFKGNCSVSFIDQFKALHQCNKYC 239
Alpha_kinase_ALPK2_3 cd16966
Alpha-kinase domain of alpha-protein kinases 2 and 3; Alpha-protein kinases 2 (ALPK2) and 3 ...
 215-318 7.36e-04

Alpha-kinase domain of alpha-protein kinases 2 and 3; Alpha-protein kinases 2 (ALPK2) and 3 (ALPK3) are also called heart alpha-protein kinase (HAK) and muscle alpha-protein kinase (MAK), respectively. They both contain a C-terminal alpha-kinase domain and two immunoglobulin (Ig)-like domains. Loss of function mutations in ALPK3 can cause early-onset and familial cardiomyopathy in humans. The ALPK2 gene may also be a novel candidate gene for inherited hypertension in Dahl rats. Alpha-kinase is an atypical protein kinase catalytic domain with no detectable similarity to conventional protein serine/threonine kinases. The alpha-kinase family was named after the unique mode of substrate recognition by its initial members, the Dictyostelium heavy chain kinases, which targeted protein sequences that adopt an alpha-helical conformation. More recently, alpha-kinases were found to also target residues in non-helical regions.


Pssm-ID: 341216  Cd Length: 239  Bit Score: 41.79  E-value: 7.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844083993 215 IELKDRPGK--PLFHLEHYIEGKYIKYNSNSG-----FVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQI 287
Cdd:cd16966   128 LFLIYRPANniPYATVEEELIGPFVKYSIRDGkeinfLRSESEAGQKCCTFQHWVYQWTNGCLLVTDLQGVGMKLTDVGI 207

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1844083993 288 HTETgtdfgDGNLGVRG---MAL---FFYSHACNRIC 318
Cdd:cd16966   208 ATLA-----KGYQGLKGncsMTFidqFAALHQCNKYC 239
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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