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Conserved domains on  [gi|7669542|ref|NP_054698|]
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paired box protein Pax-8 isoform PAX8E [Homo sapiens]

Protein Classification

paired box protein( domain architecture ID 10646818)

paired box protein binds DNA and may function as a transcription factor with a possible significant role in cell fate specification and tissue differentiation during animal ontogeny

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PAX smart00351
Paired Box domain;
9-133 1.31e-85

Paired Box domain;


:

Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 251.86  E-value: 1.31e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7669542       9 GHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPKV 88
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLCVSHGCVSKILGRYYETGSIRPGAIGGSKPKVATPKV 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 7669542      89 VEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIR 133
Cdd:smart00351  81 VKKIADYKQENPGIFAWEIRDRLLSEGVCDKDNVPSVSSINRILR 125
 
Name Accession Description Interval E-value
PAX smart00351
Paired Box domain;
9-133 1.31e-85

Paired Box domain;


Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 251.86  E-value: 1.31e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7669542       9 GHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPKV 88
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLCVSHGCVSKILGRYYETGSIRPGAIGGSKPKVATPKV 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 7669542      89 VEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIR 133
Cdd:smart00351  81 VKKIADYKQENPGIFAWEIRDRLLSEGVCDKDNVPSVSSINRILR 125
PAX cd00131
Paired Box domain
9-135 1.06e-81

Paired Box domain


Pssm-ID: 238076  Cd Length: 128  Bit Score: 241.94  E-value: 1.06e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7669542    9 GHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPKV 88
Cdd:cd00131   1 GQGGVNQLGGVFVNGRPLPDSIRQRIVELAQSGIRPCDISRQLRVSHGCVSKILNRYYETGSIRPGAIGGSKPRVATPEV 80
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 7669542   89 VEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTK 135
Cdd:cd00131  81 VKKIEIYKQENPGMFAWEIRDRLLQEGVCDKSNVPSVSSINRILRNK 127
PAX pfam00292
'Paired box' domain;
9-133 1.31e-80

'Paired box' domain;


Pssm-ID: 366005  Cd Length: 125  Bit Score: 239.39  E-value: 1.31e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7669542      9 GHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPKV 88
Cdd:pfam00292   1 GHGGVNQLGGVFVNGRPLPDHIRQKIVELAHSGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPEV 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 7669542     89 VEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIR 133
Cdd:pfam00292  81 VTKIAEYKRENPSIFAWEIRDRLLKEGVCDNDTVPSVSSINRILR 125
Csa3 COG3415
CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein ...
28-133 2.11e-06

CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein Csa3, CARF domain is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 442641 [Multi-domain]  Cd Length: 325  Bit Score: 48.31  E-value: 2.11e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7669542   28 EVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGRYYETG--SIRPGVIGGSKPKVaTPKVVEKIGDY-KRQNPTMFA 104
Cdd:COG3415  25 EARRLRAVLLLAEGLSVREIAERLGVSRSTVYRWLKRYREGGlaGLKDRPRGGRPSKL-SDEQRERLLELlREKSPDQGS 103
                        90       100       110
                ....*....|....*....|....*....|....
gi 7669542  105 -W---EIRDRLLAE-GVcdndTVpSVSSINRIIR 133
Cdd:COG3415 104 rWtlaELAELLEEEfGV----EV-SPSTVRRLLK 132
 
Name Accession Description Interval E-value
PAX smart00351
Paired Box domain;
9-133 1.31e-85

Paired Box domain;


Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 251.86  E-value: 1.31e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7669542       9 GHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPKV 88
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLCVSHGCVSKILGRYYETGSIRPGAIGGSKPKVATPKV 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 7669542      89 VEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIR 133
Cdd:smart00351  81 VKKIADYKQENPGIFAWEIRDRLLSEGVCDKDNVPSVSSINRILR 125
PAX cd00131
Paired Box domain
9-135 1.06e-81

Paired Box domain


Pssm-ID: 238076  Cd Length: 128  Bit Score: 241.94  E-value: 1.06e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7669542    9 GHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPKV 88
Cdd:cd00131   1 GQGGVNQLGGVFVNGRPLPDSIRQRIVELAQSGIRPCDISRQLRVSHGCVSKILNRYYETGSIRPGAIGGSKPRVATPEV 80
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 7669542   89 VEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTK 135
Cdd:cd00131  81 VKKIEIYKQENPGMFAWEIRDRLLQEGVCDKSNVPSVSSINRILRNK 127
PAX pfam00292
'Paired box' domain;
9-133 1.31e-80

'Paired box' domain;


Pssm-ID: 366005  Cd Length: 125  Bit Score: 239.39  E-value: 1.31e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7669542      9 GHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPKV 88
Cdd:pfam00292   1 GHGGVNQLGGVFVNGRPLPDHIRQKIVELAHSGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPEV 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 7669542     89 VEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIR 133
Cdd:pfam00292  81 VTKIAEYKRENPSIFAWEIRDRLLKEGVCDNDTVPSVSSINRILR 125
Csa3 COG3415
CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein ...
28-133 2.11e-06

CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein Csa3, CARF domain is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 442641 [Multi-domain]  Cd Length: 325  Bit Score: 48.31  E-value: 2.11e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7669542   28 EVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGRYYETG--SIRPGVIGGSKPKVaTPKVVEKIGDY-KRQNPTMFA 104
Cdd:COG3415  25 EARRLRAVLLLAEGLSVREIAERLGVSRSTVYRWLKRYREGGlaGLKDRPRGGRPSKL-SDEQRERLLELlREKSPDQGS 103
                        90       100       110
                ....*....|....*....|....*....|....
gi 7669542  105 -W---EIRDRLLAE-GVcdndTVpSVSSINRIIR 133
Cdd:COG3415 104 rWtlaELAELLEEEfGV----EV-SPSTVRRLLK 132
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
30-72 5.85e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 34.97  E-value: 5.85e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 7669542   30 VRQRIVD-LAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIR 72
Cdd:cd00090   8 TRLRILRlLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVE 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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