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Conserved domains on  [gi|7662056|ref|NP_054723|]
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protocadherin gamma-A8 isoform 2 precursor [Homo sapiens]

Protein Classification

protocadherin( domain architecture ID 11175748)

protocadherin may have tightly regulated functions in the development, regionalization, and functional differentiation of the central nervous system

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-112 3.99e-40

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 142.28  E-value: 3.99e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056     30 QIRYSVPEETDKGSFVGNISKDLGLDPRKLAKHGVRIVSRGRTQLFALNPRSGSLITAGRIDREELCAQSPRCLININTL 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 7662056    110 VED 112
Cdd:pfam08266  81 LEN 83
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 688-772 7.61e-36

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


:

Pssm-ID: 465139  Cd Length: 84  Bit Score: 129.95  E-value: 7.61e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056    688 SLTLYLVVAVAAISCVFLAFVAVLLGLRLRRWHKSRLLQDSGGrLVGVPASHFVGVEEVQAFLQTYSQEVSLTADSRKSH 767
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSSGN-LCSVPAPHFPGNDGTGTLPQSYSYEVCLTSDSGKSE 79


                  ....*
gi 7662056    768 LIFPQ 772
Cdd:pfam16492  80 FKFLK 84
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-343 4.45e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.33  E-value: 4.45e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056  246 IYRVKVLENMPPGTRLLTVTASDPDEGINGKVAYKFRKINEKQtpLFQLNENTGEISIAKSLDYEECSFYEMEIQAEDVG 325
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG--LFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                        90       100
                ....*....|....*....|
gi 7662056  326 --ALLGRTKLLISVEDVNDN 343
Cdd:cd11304  79 gpPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 456-558 6.56e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.17  E-value: 6.56e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056  456 SYSAYILENNLRGASIFSLTAHDPDSQENAQVTYSvtedtLQGAPLSSYISINSDTGVLYALQSFDYEQIRDLQLLVTAS 535
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYS-----IVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 7662056  536 DSGDPPLSSNMSLSLFVLDQNDN 558
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-238 3.60e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.08  E-value: 3.60e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056  139 EVKINEIAVPGARYPLPEAVDPDVGVNSLQSYQLS---PNHHFSLDVQTGdngainpELVLERALDREEEAAHHLVLTAS 215
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSIDPSTG-------EITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 7662056  216 DGGKPPRSSTVRIHVTVLDTNDN 238
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 356-448 4.09e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 4.09e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056  356 VLENSLPGTVIAFLSVHDQDSGKNGQVVCY---TRDNLPFKLEKSIGNyyrLVTRKYLDRENVSIYNITVMASDLGTPPL 432
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSivsGNEDGLFSIDPSTGE---ITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*.
gi 7662056  433 STETQIALHVADINDN 448
Cdd:cd11304  83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 579-666 1.84e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.38  E-value: 1.84e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056  579 PRSAERGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-SLVVAVQDHGQPPLSAT 657
Cdd:cd11304   7 PENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKP-LDREEQSSyTLTVTATDGGGPPLSST 85


                ....*....
gi 7662056  658 VTLTVAVAD 666
Cdd:cd11304  86 ATVTITVLD 94
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-112 3.99e-40

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 142.28  E-value: 3.99e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056     30 QIRYSVPEETDKGSFVGNISKDLGLDPRKLAKHGVRIVSRGRTQLFALNPRSGSLITAGRIDREELCAQSPRCLININTL 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 7662056    110 VED 112
Cdd:pfam08266  81 LEN 83
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 688-772 7.61e-36

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 129.95  E-value: 7.61e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056    688 SLTLYLVVAVAAISCVFLAFVAVLLGLRLRRWHKSRLLQDSGGrLVGVPASHFVGVEEVQAFLQTYSQEVSLTADSRKSH 767
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSSGN-LCSVPAPHFPGNDGTGTLPQSYSYEVCLTSDSGKSE 79


                  ....*
gi 7662056    768 LIFPQ 772
Cdd:pfam16492  80 FKFLK 84
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-343 4.45e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.33  E-value: 4.45e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056  246 IYRVKVLENMPPGTRLLTVTASDPDEGINGKVAYKFRKINEKQtpLFQLNENTGEISIAKSLDYEECSFYEMEIQAEDVG 325
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG--LFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                        90       100
                ....*....|....*....|
gi 7662056  326 --ALLGRTKLLISVEDVNDN 343
Cdd:cd11304  79 gpPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 456-558 6.56e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.17  E-value: 6.56e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056  456 SYSAYILENNLRGASIFSLTAHDPDSQENAQVTYSvtedtLQGAPLSSYISINSDTGVLYALQSFDYEQIRDLQLLVTAS 535
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYS-----IVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 7662056  536 DSGDPPLSSNMSLSLFVLDQNDN 558
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-238 3.60e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.08  E-value: 3.60e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056  139 EVKINEIAVPGARYPLPEAVDPDVGVNSLQSYQLS---PNHHFSLDVQTGdngainpELVLERALDREEEAAHHLVLTAS 215
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSIDPSTG-------EITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 7662056  216 DGGKPPRSSTVRIHVTVLDTNDN 238
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 356-448 4.09e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 4.09e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056  356 VLENSLPGTVIAFLSVHDQDSGKNGQVVCY---TRDNLPFKLEKSIGNyyrLVTRKYLDRENVSIYNITVMASDLGTPPL 432
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSivsGNEDGLFSIDPSTGE---ITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*.
gi 7662056  433 STETQIALHVADINDN 448
Cdd:cd11304  83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 579-666 1.84e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.38  E-value: 1.84e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056  579 PRSAERGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-SLVVAVQDHGQPPLSAT 657
Cdd:cd11304   7 PENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKP-LDREEQSSyTLTVTATDGGGPPLSST 85


                ....*....
gi 7662056  658 VTLTVAVAD 666
Cdd:cd11304  86 ATVTITVLD 94
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 157-240 1.48e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 89.33  E-value: 1.48e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056     157 AVDPDVGVNSLQSYQLSPN---HHFSLDVQTGdngainpELVLERALDREEEAAHHLVLTASDGGKPPRSSTVRIHVTVL 233
Cdd:smart00112   2 ATDADSGENGKVTYSILSGnddGLFSIDPETG-------EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*..
gi 7662056     234 DTNDNAP 240
Cdd:smart00112  75 DVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 475-560 2.12e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.95  E-value: 2.12e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056     475 TAHDPDSQENAQVTYSVTEDTLQGaplssYISINSDTGVLYALQSFDYEQIRDLQLLVTASDSGDPPLSSNMSLSLFVLD 554
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDG-----LFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 7662056     555 QNDNAP 560
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-345 1.07e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.94  E-value: 1.07e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056     265 TASDPDEGINGKVAYkfRKINEKQTPLFQLNENTGEISIAKSLDYEECSFYEMEIQAEDVG--ALLGRTKLLISVEDVND 342
Cdd:smart00112   1 SATDADSGENGKVTY--SILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGgpPLSSTATVTITVLDVND 78


                   ...
gi 7662056     343 NRP 345
Cdd:smart00112  79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 370-450 1.91e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.47  E-value: 1.91e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056     370 SVHDQDSGKNGQVVC---YTRDNLPFKLEKSIGnyyRLVTRKYLDRENVSIYNITVMASDLGTPPLSTETQIALHVADIN 446
Cdd:smart00112   1 SATDADSGENGKVTYsilSGNDDGLFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 7662056     447 DNPP 450
Cdd:smart00112  78 DNAP 81
Cadherin pfam00028
Cadherin domain;
247-338 2.92e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.42  E-value: 2.92e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056    247 YRVKVLENMPPGTRLLTVTASDPDEGINGKVAYKFRKINEKQTplFQLNENTGEISIAKSLDYEECSFYEMEIQAEDVG- 325
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN--FRIDPDTGDISTTKPLDRESIGEYELTVEATDSGg 78

                          90
                  ....*....|....
gi 7662056    326 -ALLGRTKLLISVE 338
Cdd:pfam00028  79 pPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 592-666 2.87e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.00  E-value: 2.87e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7662056     592 VAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-SLVVAVQDHGQPPLSATVTLTVAVAD 666
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKP-LDREEQPEyTLTVEATDGGGPPLSSTATVTITVLD 75
Cadherin pfam00028
Cadherin domain;
457-553 3.65e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.26  E-value: 3.65e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056    457 YSAYILENNLRGASIFSLTAHDPDSQENAQVTYSVTEDtlqgaPLSSYISINSDTGVLYALQSFDYEQIRDLQLLVTASD 536
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG-----GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 7662056    537 SGDPPLSSNMSLSLFVL 553
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
579-664 7.19e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.79  E-value: 7.19e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056    579 PRSAERGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-SLVVAVQDHGQPPLSAT 657
Cdd:pfam00028   6 PENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKP-LDRESIGEyELTVEATDSGGPPLSST 84


                  ....*..
gi 7662056    658 VTLTVAV 664
Cdd:pfam00028  85 ATVTITV 91
Cadherin pfam00028
Cadherin domain;
157-233 8.20e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.71  E-value: 8.20e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056    157 AVDPDVGVNSLQSYQLS---PNHHFSLDVQTGDngainpeLVLERALDREEEAAHHLVLTASDGGKPPRSSTVRIHVTVL 233
Cdd:pfam00028  20 ATDPDLGPNGRIFYSILgggPGGNFRIDPDTGD-------ISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
356-442 1.04e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.33  E-value: 1.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056    356 VLENSLPGTVIAFLSVHDQDSGKNGQVVcY--TRDNLP--FKLEKSIGnyyRLVTRKYLDRENVSIYNITVMASDLGTPP 431
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIF-YsiLGGGPGgnFRIDPDTG---DISTTKPLDRESIGEYELTVEATDSGGPP 80

                          90
                  ....*....|.
gi 7662056    432 LSTETQIALHV 442
Cdd:pfam00028  81 LSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 30-129 8.63e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 56.55  E-value: 8.63e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056   30 QIRYSVPEETDKGSFVGNIS-KDLglDPRKLAKHGVRIVSRGRTQLFALNPRSGSLITAGRIDREElcaqspRCLININT 108
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSaTDP--DSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREE------QSSYTLTV 72

                        90       100
                ....*....|....*....|....*.
gi 7662056  109 LVEDKGK--LFG---VEIEIIDINDN 129
Cdd:cd11304  73 TATDGGGppLSStatVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 65-131 2.14e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 46.19  E-value: 2.14e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7662056      65 RIVSRGRTQLFALNPRSGSLITAGRIDREELcaqsPRCLINIntLVEDKGK--LFG---VEIEIIDINDNNP 131
Cdd:smart00112  16 SILSGNDDGLFSIDPETGEITTTKPLDREEQ----PEYTLTV--EATDGGGppLSStatVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 30-112 3.99e-40

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 142.28  E-value: 3.99e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056     30 QIRYSVPEETDKGSFVGNISKDLGLDPRKLAKHGVRIVSRGRTQLFALNPRSGSLITAGRIDREELCAQSPRCLININTL 109
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 7662056    110 VED 112
Cdd:pfam08266  81 LEN 83
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 688-772 7.61e-36

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 129.95  E-value: 7.61e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056    688 SLTLYLVVAVAAISCVFLAFVAVLLGLRLRRWHKSRLLQDSGGrLVGVPASHFVGVEEVQAFLQTYSQEVSLTADSRKSH 767
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSSGN-LCSVPAPHFPGNDGTGTLPQSYSYEVCLTSDSGKSE 79


                  ....*
gi 7662056    768 LIFPQ 772
Cdd:pfam16492  80 FKFLK 84
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-343 4.45e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.33  E-value: 4.45e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056  246 IYRVKVLENMPPGTRLLTVTASDPDEGINGKVAYKFRKINEKQtpLFQLNENTGEISIAKSLDYEECSFYEMEIQAEDVG 325
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG--LFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                        90       100
                ....*....|....*....|
gi 7662056  326 --ALLGRTKLLISVEDVNDN 343
Cdd:cd11304  79 gpPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 456-558 6.56e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 108.17  E-value: 6.56e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056  456 SYSAYILENNLRGASIFSLTAHDPDSQENAQVTYSvtedtLQGAPLSSYISINSDTGVLYALQSFDYEQIRDLQLLVTAS 535
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYS-----IVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 7662056  536 DSGDPPLSSNMSLSLFVLDQNDN 558
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-238 3.60e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 100.08  E-value: 3.60e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056  139 EVKINEIAVPGARYPLPEAVDPDVGVNSLQSYQLS---PNHHFSLDVQTGdngainpELVLERALDREEEAAHHLVLTAS 215
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgnEDGLFSIDPSTG-------EITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 7662056  216 DGGKPPRSSTVRIHVTVLDTNDN 238
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 356-448 4.09e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 4.09e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056  356 VLENSLPGTVIAFLSVHDQDSGKNGQVVCY---TRDNLPFKLEKSIGNyyrLVTRKYLDRENVSIYNITVMASDLGTPPL 432
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSivsGNEDGLFSIDPSTGE---ITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*.
gi 7662056  433 STETQIALHVADINDN 448
Cdd:cd11304  83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 579-666 1.84e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 92.38  E-value: 1.84e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056  579 PRSAERGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-SLVVAVQDHGQPPLSAT 657
Cdd:cd11304   7 PENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKP-LDREEQSSyTLTVTATDGGGPPLSST 85


                ....*....
gi 7662056  658 VTLTVAVAD 666
Cdd:cd11304  86 ATVTITVLD 94
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 157-240 1.48e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 89.33  E-value: 1.48e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056     157 AVDPDVGVNSLQSYQLSPN---HHFSLDVQTGdngainpELVLERALDREEEAAHHLVLTASDGGKPPRSSTVRIHVTVL 233
Cdd:smart00112   2 ATDADSGENGKVTYSILSGnddGLFSIDPETG-------EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*..
gi 7662056     234 DTNDNAP 240
Cdd:smart00112  75 DVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 475-560 2.12e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.95  E-value: 2.12e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056     475 TAHDPDSQENAQVTYSVTEDTLQGaplssYISINSDTGVLYALQSFDYEQIRDLQLLVTASDSGDPPLSSNMSLSLFVLD 554
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDG-----LFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 7662056     555 QNDNAP 560
Cdd:smart00112  76 VNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-345 1.07e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.94  E-value: 1.07e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056     265 TASDPDEGINGKVAYkfRKINEKQTPLFQLNENTGEISIAKSLDYEECSFYEMEIQAEDVG--ALLGRTKLLISVEDVND 342
Cdd:smart00112   1 SATDADSGENGKVTY--SILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGgpPLSSTATVTITVLDVND 78


                   ...
gi 7662056     343 NRP 345
Cdd:smart00112  79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 370-450 1.91e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.47  E-value: 1.91e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056     370 SVHDQDSGKNGQVVC---YTRDNLPFKLEKSIGnyyRLVTRKYLDRENVSIYNITVMASDLGTPPLSTETQIALHVADIN 446
Cdd:smart00112   1 SATDADSGENGKVTYsilSGNDDGLFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 7662056     447 DNPP 450
Cdd:smart00112  78 DNAP 81
Cadherin pfam00028
Cadherin domain;
247-338 2.92e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.42  E-value: 2.92e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056    247 YRVKVLENMPPGTRLLTVTASDPDEGINGKVAYKFRKINEKQTplFQLNENTGEISIAKSLDYEECSFYEMEIQAEDVG- 325
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN--FRIDPDTGDISTTKPLDRESIGEYELTVEATDSGg 78

                          90
                  ....*....|....
gi 7662056    326 -ALLGRTKLLISVE 338
Cdd:pfam00028  79 pPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 592-666 2.87e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.00  E-value: 2.87e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7662056     592 VAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-SLVVAVQDHGQPPLSATVTLTVAVAD 666
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKP-LDREEQPEyTLTVEATDGGGPPLSSTATVTITVLD 75
Cadherin pfam00028
Cadherin domain;
457-553 3.65e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.26  E-value: 3.65e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056    457 YSAYILENNLRGASIFSLTAHDPDSQENAQVTYSVTEDtlqgaPLSSYISINSDTGVLYALQSFDYEQIRDLQLLVTASD 536
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG-----GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                          90
                  ....*....|....*..
gi 7662056    537 SGDPPLSSNMSLSLFVL 553
Cdd:pfam00028  76 SGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
579-664 7.19e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.79  E-value: 7.19e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056    579 PRSAERGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARAlLDRDALKQ-SLVVAVQDHGQPPLSAT 657
Cdd:pfam00028   6 PENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKP-LDRESIGEyELTVEATDSGGPPLSST 84


                  ....*..
gi 7662056    658 VTLTVAV 664
Cdd:pfam00028  85 ATVTITV 91
Cadherin pfam00028
Cadherin domain;
157-233 8.20e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.71  E-value: 8.20e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056    157 AVDPDVGVNSLQSYQLS---PNHHFSLDVQTGDngainpeLVLERALDREEEAAHHLVLTASDGGKPPRSSTVRIHVTVL 233
Cdd:pfam00028  20 ATDPDLGPNGRIFYSILgggPGGNFRIDPDTGD-------ISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
356-442 1.04e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.33  E-value: 1.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056    356 VLENSLPGTVIAFLSVHDQDSGKNGQVVcY--TRDNLP--FKLEKSIGnyyRLVTRKYLDRENVSIYNITVMASDLGTPP 431
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIF-YsiLGGGPGgnFRIDPDTG---DISTTKPLDRESIGEYELTVEATDSGGPP 80

                          90
                  ....*....|.
gi 7662056    432 LSTETQIALHV 442
Cdd:pfam00028  81 LSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 30-129 8.63e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 56.55  E-value: 8.63e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056   30 QIRYSVPEETDKGSFVGNIS-KDLglDPRKLAKHGVRIVSRGRTQLFALNPRSGSLITAGRIDREElcaqspRCLININT 108
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSaTDP--DSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREE------QSSYTLTV 72

                        90       100
                ....*....|....*....|....*.
gi 7662056  109 LVEDKGK--LFG---VEIEIIDINDN 129
Cdd:cd11304  73 TATDGGGppLSStatVTITVLDVNDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 31-129 6.64e-09

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 53.89  E-value: 6.64e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662056   31 IRYSVPEETDKGSFVGNISKDLGldprKLAKHGVRIVSRGR---TQLFALNPRSGSLITAGRIDREELC-------AQSP 100
Cdd:cd00031   2 PDGSAVEGRSRGSFRVSIPTDLI----ASSGEIIKISAAGKealPSWLHWEPHSGILEGLEKLDREDKGvhyisvsAASL 77

                        90       100
                ....*....|....*....|....*....
gi 7662056  101 RCLININTLVedkgklfgVEIEIIDINDN 129
Cdd:cd00031  78 GANVPQTSSV--------FSIEVYDENDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 65-131 2.14e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 46.19  E-value: 2.14e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7662056      65 RIVSRGRTQLFALNPRSGSLITAGRIDREELcaqsPRCLINIntLVEDKGK--LFG---VEIEIIDINDNNP 131
Cdd:smart00112  16 SILSGNDDGLFSIDPETGEITTTKPLDREEQ----PEYTLTV--EATDGGGppLSStatVTITVLDVNDNAP 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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