signal peptidase complex subunit 1 [Homo sapiens]
Protein Classification
signal peptidase complex subunit 1 family protein( domain architecture ID 10535222)
signal peptidase complex subunit 1 (SPCS1) family protein is a component of the microsomal signal peptidase complex (SPC) which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| SPC12 | pfam06645 | Microsomal signal peptidase 12 kDa subunit (SPC12); This family consists of several microsomal ... |
12-82 | 6.32e-34 | ||
Microsomal signal peptidase 12 kDa subunit (SPC12); This family consists of several microsomal signal peptidase 12 kDa subunit proteins. Translocation of polypeptide chains across the endoplasmic reticulum (ER) membrane is triggered by signal sequences. Subsequently, signal recognition particle interacts with its membrane receptor and the ribosome-bound nascent chain is targeted to the ER where it is transferred into a protein-conducting channel. At some point, a second signal sequence recognition event takes place in the membrane and translocation of the nascent chain through the membrane occurs. The signal sequence of most secretory and membrane proteins is cleaved off at this stage. Cleavage occurs by the signal peptidase complex (SPC) as soon as the lumenal domain of the translocating polypeptide is large enough to expose its cleavage site to the enzyme. The signal peptidase complex is possibly also involved in proteolytic events in the ER membrane other than the processing of the signal sequence, for example the further digestion of the cleaved signal peptide or the degradation of membrane proteins. Mammalian signal peptidase is as a complex of five different polypeptide chains. This family represents the 12 kDa subunit (SPC12). : Pssm-ID: 461973 Cd Length: 71 Bit Score: 111.45 E-value: 6.32e-34
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| Name | Accession | Description | Interval | E-value | ||
| SPC12 | pfam06645 | Microsomal signal peptidase 12 kDa subunit (SPC12); This family consists of several microsomal ... |
12-82 | 6.32e-34 | ||
Microsomal signal peptidase 12 kDa subunit (SPC12); This family consists of several microsomal signal peptidase 12 kDa subunit proteins. Translocation of polypeptide chains across the endoplasmic reticulum (ER) membrane is triggered by signal sequences. Subsequently, signal recognition particle interacts with its membrane receptor and the ribosome-bound nascent chain is targeted to the ER where it is transferred into a protein-conducting channel. At some point, a second signal sequence recognition event takes place in the membrane and translocation of the nascent chain through the membrane occurs. The signal sequence of most secretory and membrane proteins is cleaved off at this stage. Cleavage occurs by the signal peptidase complex (SPC) as soon as the lumenal domain of the translocating polypeptide is large enough to expose its cleavage site to the enzyme. The signal peptidase complex is possibly also involved in proteolytic events in the ER membrane other than the processing of the signal sequence, for example the further digestion of the cleaved signal peptide or the degradation of membrane proteins. Mammalian signal peptidase is as a complex of five different polypeptide chains. This family represents the 12 kDa subunit (SPC12). Pssm-ID: 461973 Cd Length: 71 Bit Score: 111.45 E-value: 6.32e-34
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| Name | Accession | Description | Interval | E-value | ||
| SPC12 | pfam06645 | Microsomal signal peptidase 12 kDa subunit (SPC12); This family consists of several microsomal ... |
12-82 | 6.32e-34 | ||
Microsomal signal peptidase 12 kDa subunit (SPC12); This family consists of several microsomal signal peptidase 12 kDa subunit proteins. Translocation of polypeptide chains across the endoplasmic reticulum (ER) membrane is triggered by signal sequences. Subsequently, signal recognition particle interacts with its membrane receptor and the ribosome-bound nascent chain is targeted to the ER where it is transferred into a protein-conducting channel. At some point, a second signal sequence recognition event takes place in the membrane and translocation of the nascent chain through the membrane occurs. The signal sequence of most secretory and membrane proteins is cleaved off at this stage. Cleavage occurs by the signal peptidase complex (SPC) as soon as the lumenal domain of the translocating polypeptide is large enough to expose its cleavage site to the enzyme. The signal peptidase complex is possibly also involved in proteolytic events in the ER membrane other than the processing of the signal sequence, for example the further digestion of the cleaved signal peptide or the degradation of membrane proteins. Mammalian signal peptidase is as a complex of five different polypeptide chains. This family represents the 12 kDa subunit (SPC12). Pssm-ID: 461973 Cd Length: 71 Bit Score: 111.45 E-value: 6.32e-34
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