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Conserved domains on  [gi|14140236|ref|NP_055042|]
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probable glucose sensor protein SLC5A4 [Homo sapiens]

Protein Classification

SLC5/6 family protein( domain architecture ID 124)

SLC5/6 (solute carrier 5/6) family protein may function as a transporter

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SLC5-6-like_sbd super family cl00456
Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the ...
 27-659 0e+00

Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporters or solute sodium symporters), SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporters or Na+/Cl--dependent transporters), and nucleobase-cation-symport-1 (NCS1) transporters. SLC5s co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. SLC6s include Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin, dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. Members of this superfamily are important in human physiology and disease. They contain a functional core of 10 transmembrane helices (TMs): an inverted structural repeat, TMs1-5 and TMs6-10; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT.


The actual alignment was detected with superfamily member cd11486:

Pssm-ID: 444915  Cd Length: 636  Bit Score: 1039.90  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  27 ADISVIVIYFLVVMAVGLWAMLKTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSS 106
Cdd:cd11486   1 ADISVIVIYFVVVLAVGVWAMVSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGIAGTGAAAGIAIGGFEWNAL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 107 VMLLILGWIFVPIYIKSGVMTMPEYLKKRFGGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLA 186
Cdd:cd11486  81 VVVVVLGWLFVPIYIKAGVVTMPEYLRKRFGGQRIQVYLSVLSLCLYIFTKISADIFSGAIFINLALGLNLYLAIVILLA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 187 MTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEKYVNATPSVVEGDNLTISASCYTPRADSFHIF 266
Cdd:cd11486 161 ITALYTITGGLAAVIYTDTLQTIIMVVGSFILMGFAFNEVGGYDAFMEKYMTAIPSVIGTGNSTSQEKCYTPRADSFHIF 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 267 RDAVTGDIPWPGIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACV 346
Cdd:cd11486 241 RDPITGDLPWPGLLFGLSILTLWYWCTDQVIVQRCLSAKNMSHVKAGCILCGYLKLLPMFIMVMPGMISRILYTDEIACV 320

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 347 VPSECVKHCGVDVGCTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAG 426
Cdd:cd11486 321 VPDECKAVCGTEVGCTNIAYPKLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYTKVRKKASEKELMIAG 400

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 427 RIFVLLLTVVSIVWVPLVQVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITEFAY 506
Cdd:cd11486 401 RLFMLVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFCKRVNEPGAFWGLCVGLLVGLARMITEFAY 480

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 507 GTGSCLAPSNCPKIICGVHYLYFSIVLFFGSMLVTLGISLLTKPIPDVHLYRLCWVLRNSTEERIDIDAEEKS-QEETDD 585
Cdd:cd11486 481 GTGSCVNPSNCPTIICGVHYLYFAIILFGISCILILSISLMTKPIPDVHLYRLCWSLRNSKEERIDLDADDETeDQDSNS 560

                       570       580       590       600       610       620       630
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 14140236 586 GVEEDYPEKSRGCLKKAYDLFCGL--QKGPKLTKEEEEALSKKLTDTSERPSWRTIVNINAILLLAVVVFIHGYYA 659
Cdd:cd11486 561 MIETDEMREEPGCCKKAYNWFCGLdqGNAPKLTKEEEAALKMKLTDTSEKPLWRNVVNANGIILLTVAVFCHAFFA 636
 
Name Accession Description Interval E-value
SLC5sbd_SGLT1 cd11486
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a ...
 27-659 0e+00

Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a high-affinity/low-capacity glucose transporter, which can also transport galactose. In the transport mechanism, two Na+ ions first bind to the extracellular side of the transporter and induce a conformational change in the glucose binding site. This results in an increased affinity for glucose. A second conformational change in the transporter follows, bringing the Na+ and glucose binding sites to the inner surface of the membrane. Glucose is then released, followed by the Na+ ions. In the process, hSGLT1 is also able to transport water and urea and may be a major pathway for transport of these across the intestinal brush-border membrane. hSGLT1 is encoded by the SLC5A1 gene and expressed mostly in the intestine, but also in the trachea, kidney, heart, brain, testis, and prostate. The WHO/UNICEF oral rehydration solution (ORS) for the treatment of secretory diarrhea contains salt and glucose. The glucose, along with sodium ions, is transported by hSGLT1 and water is either co-transported along with these or follows by osmosis. Mutations in SGLT1 are associated with intestinal glucose galactose malabsorption (GGM). Up-regulation of intestinal SGLT1 may protect against enteric infections. SGLT1 is expressed in colorectal, head and neck, and prostate tumors. Epidermal growth factor receptor (EGFR) functions in cell survival by stabilizing SGLT1, and thereby maintaining intracellular glucose levels. SGLT1 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5)transporter family.


Pssm-ID: 271379  Cd Length: 636  Bit Score: 1039.90  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  27 ADISVIVIYFLVVMAVGLWAMLKTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSS 106
Cdd:cd11486   1 ADISVIVIYFVVVLAVGVWAMVSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGIAGTGAAAGIAIGGFEWNAL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 107 VMLLILGWIFVPIYIKSGVMTMPEYLKKRFGGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLA 186
Cdd:cd11486  81 VVVVVLGWLFVPIYIKAGVVTMPEYLRKRFGGQRIQVYLSVLSLCLYIFTKISADIFSGAIFINLALGLNLYLAIVILLA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 187 MTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEKYVNATPSVVEGDNLTISASCYTPRADSFHIF 266
Cdd:cd11486 161 ITALYTITGGLAAVIYTDTLQTIIMVVGSFILMGFAFNEVGGYDAFMEKYMTAIPSVIGTGNSTSQEKCYTPRADSFHIF 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 267 RDAVTGDIPWPGIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACV 346
Cdd:cd11486 241 RDPITGDLPWPGLLFGLSILTLWYWCTDQVIVQRCLSAKNMSHVKAGCILCGYLKLLPMFIMVMPGMISRILYTDEIACV 320

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 347 VPSECVKHCGVDVGCTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAG 426
Cdd:cd11486 321 VPDECKAVCGTEVGCTNIAYPKLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYTKVRKKASEKELMIAG 400

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 427 RIFVLLLTVVSIVWVPLVQVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITEFAY 506
Cdd:cd11486 401 RLFMLVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFCKRVNEPGAFWGLCVGLLVGLARMITEFAY 480

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 507 GTGSCLAPSNCPKIICGVHYLYFSIVLFFGSMLVTLGISLLTKPIPDVHLYRLCWVLRNSTEERIDIDAEEKS-QEETDD 585
Cdd:cd11486 481 GTGSCVNPSNCPTIICGVHYLYFAIILFGISCILILSISLMTKPIPDVHLYRLCWSLRNSKEERIDLDADDETeDQDSNS 560

                       570       580       590       600       610       620       630
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 14140236 586 GVEEDYPEKSRGCLKKAYDLFCGL--QKGPKLTKEEEEALSKKLTDTSERPSWRTIVNINAILLLAVVVFIHGYYA 659
Cdd:cd11486 561 MIETDEMREEPGCCKKAYNWFCGLdqGNAPKLTKEEEAALKMKLTDTSEKPLWRNVVNANGIILLTVAVFCHAFFA 636
SSF pfam00474
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ...
 58-492 2.23e-162

Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.


Pssm-ID: 109527 [Multi-domain]  Cd Length: 406  Bit Score: 471.82  E-value: 2.23e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236    58 FFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTMPEYLKKRFG 137
Cdd:pfam00474   1 YFLAGRSMTGFVNGLSLAASYMSAASFVGLAGAGAASGLAGGLYAIGALVGVWLLLWLFAPRLRNLGAYTMPDYLRKRFG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236   138 GERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFI 217
Cdd:pfam00474  81 GKRILVYLSALSLLLYFFTYMSVQIVGGARLIELALGLNYYTAVLLLGALTAIYTFFGGFLAVSWTDTIQAVLMLFGTII 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236   218 LMGFAFNEVGGYESFTEKYVNATPSVVegDNLTisascytprADSFHIFRDAVTGDIPWPGIIFGMPITalwywctnQVI 297
Cdd:pfam00474 161 LMIIVFHEVGGYSSAVEKYMTADPNGV--DLYT---------PDGLHILRDPLTGLSLWPGLVLGTTGL--------PHI 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236   298 VQRCLCGKDmshvkAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACVVPsecvKHCGVDVGCTNYAYPTMVLELMPQG 377
Cdd:pfam00474 222 LQRCLAAKD-----AKCIRCGVLILTPMFIIVMPGMISRGLFAIALAGANP----RACGTVVGCSNIAYPTLAVKLGPPG 292

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236   378 LRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGRIFVLLLTVVSIVWVPLVQVSQNGqLIHYTE 457
Cdd:pfam00474 293 LAGIMLAVMLAAIMSTLTSQLLSSSSAFTHDLYKNIRRKASATEKELVGRSRIIVLVVISLAILLAVQPAQMG-IAFLVQ 371

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 14140236   458 SISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVG 492
Cdd:pfam00474 372 LAFAGLGSAFLPVILLAIFWKRVNEQGALWGMIIG 406
sss TIGR00813
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ...
 61-492 7.77e-157

transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273282 [Multi-domain]  Cd Length: 407  Bit Score: 457.92  E-value: 7.77e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236    61 AGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTMPEYLKKRFGGeR 140
Cdd:TIGR00813   1 AGRSLGGWVVAASLFASYISASQFLGLPGAIYAYGFAIGFYELGALVLLIILGWLFVPIFINNGAYTMPEYLEKRFGK-R 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236   141 LQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMG 220
Cdd:TIGR00813  80 ILRGLSVLSLILYIFLYMSVDLFSGALLIELITGLDLYLSLLLLGAITILYTVFGGLKAVVWTDTIQAVIMILGTFILPV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236   221 FAFNEVGGYESFTEKYVNATPSVvegdnltisascyTPRADSFHIFRDAVTGDIPWPGIIFGMPITALWYWcTNQVIVQR 300
Cdd:TIGR00813 160 FAFSEVGGLGTFVEKASQAAPTN-------------PSPDDLYDFFRDPSTSDLPWGAGVFGLPHVALWYW-TNQVIVQR 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236   301 CLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMvacvVPSEcvkhCGVDVGCTNYAYPTMVLELMPQGLRG 380
Cdd:TIGR00813 226 CLAAKSAKHAKKGCLISGVLKLLPMFGAVLPGLIARALYTDI----DPAL----AGAVNQNSDQAYPLLVQELMPPGLAG 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236   381 LMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGRIFVLLLTVVSIVWVplVQVSQNGQLIHYTESIS 460
Cdd:TIGR00813 298 LFLAAILAAVMSTLSSQLNSASTVFTMDLYKKIIRPNASGEKKIVMRGRIAVLVAAVIAGF--VAAAQGGQVLQYVQEAF 375

                         410       420       430
                  ....*....|....*....|....*....|..
gi 14140236   461 SYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVG 492
Cdd:TIGR00813 376 GGLGAPFLPVFLLGIFWKRMNAKGALAGMIAG 407
YidK COG4146
Uncharacterized membrane permease YidK, sodium:solute symporter family [General function ...
 25-499 3.25e-148

Uncharacterized membrane permease YidK, sodium:solute symporter family [General function prediction only];


Pssm-ID: 443317 [Multi-domain]  Cd Length: 444  Bit Score: 437.27  E-value: 3.25e-148
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  25 NAADISVIVIYFLVVMAVGLWAMLKTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWT 104
Cdd:COG4146   4 STLDYIVFLLYFLLVAGIGYWVSRKKKEKTSEDYFLAGRSLTWWVIGASLIATNISAEQLIGLNGSGYATGLAVAAYEWM 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 105 SSVMLLILGWIFVPIYIKSGVMTMPEYLKKRFgGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFIL 184
Cdd:COG4146  84 AAIALIILALFFLPFYLKSGIYTMPEFLEKRY-DRRTRTILSILFLVSYVFVNLPSVLYAGALALNTIFGVPLWISVIGL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 185 LAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGyesftekyvnatPSVVEG-DNLTISAscytprADSF 263
Cdd:COG4146 163 GIIAGIYTIFGGLKAVAYTDVIQGIGLIIGGLLITVLGLDAVGD------------GSVLAGwSALLKVP------PEKF 224

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 264 HIFRDAVTGDIPWPGIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMV 343
Cdd:COG4146 225 NMIGPADDPDLPWLGIFTGMPILNLFYWGTNQYIVQRALGAKNLKEAQKGVLFAGFLKLLIPFIVVLPGIIAFVLFPDGL 304

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 344 AcvvpsecvkhcgvdvgCTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKM-RKQASEKEL 422
Cdd:COG4146 305 D----------------NPDQAYPTLVKNLLPVGLKGLVAAALFAAIMSSLASALNSSSTLFTLDIYKKYfNPNASEKQL 368

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 14140236 423 LIAGRIFVLLLTVVSIVWVPLVQVSqnGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIR 499
Cdd:COG4146 369 VKVGRIATVVLAVIAILIAPLIGNA--DGLFQYIQEVTGFFSPPILAVFLLGLFWKRVTAKAAKVALIAGIVLSILL 443
PRK10484 PRK10484
putative transporter; Provisional
 32-547 4.13e-69

putative transporter; Provisional


Pssm-ID: 236699 [Multi-domain]  Cd Length: 523  Bit Score: 234.01  E-value: 4.13e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236   32 IVIYFLVVMAVGLWAMLKTNR---GTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVM 108
Cdd:PRK10484   4 ILSFLGFTLLVAVISWWKTRKtdtSSSDGYFLAGRSLTGPVIAGSLLLTNLSTEQLVGLNGQAYASGMSVMAWEVTAAIA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  109 LLILGWIFVPIYIKSGVMTMPEYLKKRFGGERLQVyLSILSLFICVVLLISADIFAGAI-----F-IKLALGLDLYLAIF 182
Cdd:PRK10484  84 LIILALIFLPRYLKSGITTIPDFLEERYDKTTRRI-VSILFLIGYVVSFLPIVLYSGALalnslFhVSELLGISYGAAIW 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  183 ILLAMT----AVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGyesftekyvnatpsvveGDNLTISASCYTP 258
Cdd:PRK10484 163 LLVWLIgiigAIYAVFGGLKAVAVSDTINGIGLLIGGLLVPVFGLIALGD-----------------GSFMQGLEQLTTV 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  259 RADSFHIFRDAvTGDIPWPGIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRIL 338
Cdd:PRK10484 226 HPEKLNSIGGA-TDPVPFPTLFTGLILVNLFYWCTNQSIVQRALGAKNLAEGQKGALLAAFFKLLGPLILVLPGIIAFHL 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  339 YTDMVACvvpsecvkhcgvdvgcTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLY-TKMRKQA 417
Cdd:PRK10484 305 YGDGLPN----------------ADMAYPTLVNDVLPVPLVGFFAAVLFGAILSTFNGFLNSASTLFSLDIYkPIINPNA 368

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  418 SEKELLIAGRIFVLLLTVVSIVWVPLVQVSQNGqLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVG-LAMG 496
Cdd:PRK10484 369 SEKQLVKVGKKFGFVLAIISMIVAPLIANAPQG-LYSYLQQLNGIYNVPILAIIIVGFFTKRVPALAAKVALGFGiILYI 447

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|.
gi 14140236  497 LIRMITEFaygtgsclapsncpkiicGVHYLYFSIVLFFGSMLVTLGISLL 547
Cdd:PRK10484 448 IINFVLKF------------------DIHFLYVLAILFVINVVVMLIIGKI 480
 
Name Accession Description Interval E-value
SLC5sbd_SGLT1 cd11486
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a ...
 27-659 0e+00

Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a high-affinity/low-capacity glucose transporter, which can also transport galactose. In the transport mechanism, two Na+ ions first bind to the extracellular side of the transporter and induce a conformational change in the glucose binding site. This results in an increased affinity for glucose. A second conformational change in the transporter follows, bringing the Na+ and glucose binding sites to the inner surface of the membrane. Glucose is then released, followed by the Na+ ions. In the process, hSGLT1 is also able to transport water and urea and may be a major pathway for transport of these across the intestinal brush-border membrane. hSGLT1 is encoded by the SLC5A1 gene and expressed mostly in the intestine, but also in the trachea, kidney, heart, brain, testis, and prostate. The WHO/UNICEF oral rehydration solution (ORS) for the treatment of secretory diarrhea contains salt and glucose. The glucose, along with sodium ions, is transported by hSGLT1 and water is either co-transported along with these or follows by osmosis. Mutations in SGLT1 are associated with intestinal glucose galactose malabsorption (GGM). Up-regulation of intestinal SGLT1 may protect against enteric infections. SGLT1 is expressed in colorectal, head and neck, and prostate tumors. Epidermal growth factor receptor (EGFR) functions in cell survival by stabilizing SGLT1, and thereby maintaining intracellular glucose levels. SGLT1 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5)transporter family.


Pssm-ID: 271379  Cd Length: 636  Bit Score: 1039.90  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  27 ADISVIVIYFLVVMAVGLWAMLKTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSS 106
Cdd:cd11486   1 ADISVIVIYFVVVLAVGVWAMVSTNRGTVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGIAGTGAAAGIAIGGFEWNAL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 107 VMLLILGWIFVPIYIKSGVMTMPEYLKKRFGGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLA 186
Cdd:cd11486  81 VVVVVLGWLFVPIYIKAGVVTMPEYLRKRFGGQRIQVYLSVLSLCLYIFTKISADIFSGAIFINLALGLNLYLAIVILLA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 187 MTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEKYVNATPSVVEGDNLTISASCYTPRADSFHIF 266
Cdd:cd11486 161 ITALYTITGGLAAVIYTDTLQTIIMVVGSFILMGFAFNEVGGYDAFMEKYMTAIPSVIGTGNSTSQEKCYTPRADSFHIF 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 267 RDAVTGDIPWPGIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACV 346
Cdd:cd11486 241 RDPITGDLPWPGLLFGLSILTLWYWCTDQVIVQRCLSAKNMSHVKAGCILCGYLKLLPMFIMVMPGMISRILYTDEIACV 320

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 347 VPSECVKHCGVDVGCTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAG 426
Cdd:cd11486 321 VPDECKAVCGTEVGCTNIAYPKLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYTKVRKKASEKELMIAG 400

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 427 RIFVLLLTVVSIVWVPLVQVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITEFAY 506
Cdd:cd11486 401 RLFMLVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFCKRVNEPGAFWGLCVGLLVGLARMITEFAY 480

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 507 GTGSCLAPSNCPKIICGVHYLYFSIVLFFGSMLVTLGISLLTKPIPDVHLYRLCWVLRNSTEERIDIDAEEKS-QEETDD 585
Cdd:cd11486 481 GTGSCVNPSNCPTIICGVHYLYFAIILFGISCILILSISLMTKPIPDVHLYRLCWSLRNSKEERIDLDADDETeDQDSNS 560

                       570       580       590       600       610       620       630
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 14140236 586 GVEEDYPEKSRGCLKKAYDLFCGL--QKGPKLTKEEEEALSKKLTDTSERPSWRTIVNINAILLLAVVVFIHGYYA 659
Cdd:cd11486 561 MIETDEMREEPGCCKKAYNWFCGLdqGNAPKLTKEEEAALKMKLTDTSEKPLWRNVVNANGIILLTVAVFCHAFFA 636
SLC5sbd_SGLT2 cd11487
Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 ...
 27-659 0e+00

Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain; Human SGLT2 (hSGLT2) is a high-capacity, low-affinity glucose transporter, that plays an important role in renal glucose reabsorption. It is encoded by the SLC5A2 gene and expressed almost exclusively in renal proximal tubule cells. Mutations in hSGLT2 cause Familial Renal Glucosuria (FRG), a rare autosomal defect in glucose transport. hSGLT2 is a major drug target for regulating blood glucose levels in diabetes. hSGLT2 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212056 [Multi-domain]  Cd Length: 583  Bit Score: 802.98  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  27 ADISVIVIYFLVVMAVGLWAMLKTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSS 106
Cdd:cd11487   1 ADISVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGIAVAGFEWNAL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 107 VMLLILGWIFVPIYIKSGVMTMPEYLKKRFGGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLA 186
Cdd:cd11487  81 FVVLLLGWLFVPVYLTAGVITMPQYLKKRFGGQRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 187 MTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEKYVNATPSVVEGDNLT---ISASCYTPRADSF 263
Cdd:cd11487 161 ITMIYTVTGGLAALMYTDTVQTFVIIGGACVLMGYAFHEVGGYSALFEKYLKAVPSLTVSEDPAvgnISSSCYRPRPDSY 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 264 HIFRDAVTGDIPWPGIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMV 343
Cdd:cd11487 241 HLLRDPVTGDLPWPALILGLTIVSSWYWCSDQVIVQRCLAARSLTHVKAGCILCGYLKLLPMFLMVMPGMISRVLYPDEV 320

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 344 ACVVPSECVKHCGVDVGCTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELL 423
Cdd:cd11487 321 ACVEPSVCLRVCGTEVGCSNIAYPKLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIWTRLRPQAGDKELL 400

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 424 IAGRIFVLLLTVVSIVWVPLVQVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITE 503
Cdd:cd11487 401 LVGRVWVVCIVAVSVAWIPVVQAAQGGQLFDYIQSVSSYLAPPIAAVFFLALFVKRVNEPGAFWGLIGGLLMGLCRMVPE 480

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 504 FAYGTGSCLAPSNCPKIICGVHYLYFSIVLFFGSMLVTLGISLLTKPIPDVHLYRLCWVLRNSTEERIDIdaeeksqeet 583
Cdd:cd11487 481 FSFGSGSCVAPSSCPAIICGVHYLYFAILLFFCSGLLVLIVSLCTPPIPRKHLHRLVFSLRHSKEEREDL---------- 550

                       570       580       590       600       610       620       630
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 14140236 584 ddgveedypeksrgclkkaydlfcglqkgpkltkeeeealskkLTDTSERPSWRTIVNINAILLLAVVVFIHGYYA 659
Cdd:cd11487 551 -------------------------------------------LPDISEDPKWARVVNLNALIMMAVAVFLWGFYA 583
SLC5sbd_SGLT4 cd11488
Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 ...
 28-659 0e+00

Na(+)/glucose cotransporter SGLT4 and related proteins; solute-binding domain; Human SGLT4 (hSGLT4) has been reported to be a low-affinity glucose transporter with unusual sugar selectivity: it transports D-mannose but not galactose or 3-O-methyl-D-glucoside. It is encoded by the SLC5A9 gene and is expressed in intestine, kidney, liver, brain, lung, trachea, uterus, and pancreas. hSLGT4 is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5 )transporter family.


Pssm-ID: 271380  Cd Length: 605  Bit Score: 764.86  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  28 DISVIVIYFLVVMAVGLWAMLKTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSV 107
Cdd:cd11488   1 DIAVVVVYFVFVLAVGIWSSIRASRGTVGGYFLAGRSMTWWPIGASLMSSNVGSGLFIGLAGTGAAGGLAVGGFEWNAAW 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 108 MLLILGWIFVPIYIKSGVMTMPEYLKKRFGGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAM 187
Cdd:cd11488  81 VLIALGWIFVPVYIAAGVVTMPEYLKKRFGGQRIRIYMSVLSLILYIFTKISTDIFSGALFIQVSLGWNLYLSTVILLAV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 188 TAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEKYVNATPsvvegdNLTI-SASCYTPRADSFHIF 266
Cdd:cd11488 161 TALYTIAGGLTAVIYTDALQTVIMVIGAFVLMFIAFDKVGWYPGLEQQYEKAIP------ALTVpNTTCHLPRSDAFHIF 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 267 RDAVTGDIPWPGIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACV 346
Cdd:cd11488 235 RDPVTGDIPWPGLIFGLTVLATWVWCTDQVIVQRSLSAKNLSHAKGGSVLGGYLKILPMFFVVMPGMISRALFPDEVGCV 314

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 347 VPSECVKHCGVDVGCTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAG 426
Cdd:cd11488 315 DPDECQKICGAKVGCSNIAYPKLVVELMPVGLRGLMIAVIMAALMSSLTSIFNSSSTLFTMDVWQRIRRRASEQELMVVG 394

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 427 RIFVLLLTVVSIVWVPLVQVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITEFAY 506
Cdd:cd11488 395 RVFILLLVVISILWIPIIQTANSGQLFDYIQAVTSYLSPPITAVFILAIFWKRVNEPGAFWGLMVGLVVGLVRMIMEFVY 474

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 507 GTGSCLAPSNCPKIICGVHYLYFSIVLFFGSMLVTLGISLLTKPIPDVHLYRLCWVLRNSTEERIDIdaeeksqeetddg 586
Cdd:cd11488 475 GAPSCGETDLRPSVLKDVHYLYFAIILLGLTAIVIVAVSLCTAPIPEKHLVRLTWWTRNSPEERVEL------------- 541

                       570       580       590       600       610       620       630
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14140236 587 veedypeksrgCLKKAYDLFCGLQKGPK--LTKEEEEALSKKLTDTSERPSWRTIVNINAILLLAVVVFIHGYYA 659
Cdd:cd11488 542 -----------WWKRLGMWFCGLSQTPEqdLSEEERQALEKKLTSIEEDPLWRTVCNINALILLAINVFLWGYFA 605
SLC5sbd_SGLT1-like cd10329
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily ...
 29-659 0e+00

Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily includes the solute-binding domain of SGLT proteins that cotransport Na+ with various solutes. Its members include: the human glucose (SGLT1, -2, -4, -5 ), chiro-inositol (SGLT5), and myo-inositol (SMIT) cotransporters. It also includes human SGLT3 which has been characterized as a glucose sensor and not a transporter. It belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271363  Cd Length: 538  Bit Score: 749.40  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  29 ISVIVIYFLVVMAVGLWAMLKtNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVM 108
Cdd:cd10329   1 IVIIAVYFVAVIAIGLWSSRK-KRSTVSGYFLAGRSMGWPVIGASLFASNIGSSHLVGLAGSGAASGIAVGNYEWNAAFV 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 109 LLILGWIFVPIYIKSGVMTMPEYLKKRFGGeRLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMT 188
Cdd:cd10329  80 LLLLGWVFLPFYIRSGVSTMPEFLEKRFGG-RSRVYLSVLSLILYVFTKISVDLYAGALVIKQLLGWDLYLSIIVLLVIT 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 189 AVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGyesFTEKYVNATPSVVegdnltisascytpradSFHIFRD 268
Cdd:cd10329 159 AIYTIAGGLKAVIYTDTLQAVILIIGSAILMFLAFNEVGG---GWSAYMAAIPSGT-----------------AFHLFRP 218

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 269 AVTGDIPWPGIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACVVP 348
Cdd:cd10329 219 PDDPDLPWPGLLLGYPILGIWYWCTDQVIVQRVLAAKNLKHARRGALFAGYLKLLPLFLMVLPGMIARALFPDLVACVVP 298

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 349 secvkhCGVDVGCTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGRI 428
Cdd:cd10329 299 ------CGNGVGCSDIAYPTLVTELLPVGLRGLVLAVLLAALMSSLTSIFNSASTLFTMDIYKRLRPEASEKELVRVGRI 372

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 429 FVLLLTVVSIVWVPLVQvSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITEFAYGt 508
Cdd:cd10329 373 ATLVVVVISILWAPIIQ-AQGGSLFNYIQSVLSYLAPPIAAVFLLGIFWKRTNEQGAFWGLIAGLVLGLVRLILEFAYG- 450

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 509 gsclAPSNCPKIICGVHYLYFSIVLFFGSMLVTLGISLLTKPIPDVHLYRLCWVLRnsteerididaeeksqeetddgve 588
Cdd:cd10329 451 ----EPDTRPAIIGGIHFLYFAFLLFVVSVIVTVIVSLLTPPPPAEKLAGLTWSTR------------------------ 502

                       570       580       590       600       610       620       630
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 14140236 589 edypeksrgclkkaydlfcglqkgpkltkeeeealSKKLTDTSERPSWRTIVNINAILLLAVVVFIHGYYA 659
Cdd:cd10329 503 -----------------------------------LTKETSTLERPPWYKNVRILAILLLALTIFLYGYFA 538
SLC5sbd_SGLT6 cd11490
Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human ...
 28-659 0e+00

Na(+)/chiro-inositol cotransporter SGLT6 and related proteins; solute-binding domain; Human SGLT6 (also called KST1, SMIT2) is a chiro-inositol transporter, which also transports myo-inositol. It is encoded by the SLC5A11 gene. Xenopus Na1-glucose cotransporter type 1 (SGLT-1)-like protein is predicted to contain 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271381  Cd Length: 602  Bit Score: 708.98  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  28 DISVIVIYFLVVMAVGLWAMLKTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSV 107
Cdd:cd11490   1 DIVVLVLYFLFVLAVGLWSMWKTKRSTVKGYFLAGKDMTWWPVGASLFASNVGSGHFIGLAGSGAAAGIGVVAYEWNGLF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 108 MLLILGWIFVPIYIKSGVMTMPEYLKKRFGGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAM 187
Cdd:cd11490  81 MVLVLAWLFLPIYIASRVTTMPEYLKKRFGGKRIQIFLAVLYLFIYIFTKISVDMYAGAVFIQQALQWDLYLAVVGLLGI 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 188 TAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEKYVNATPSVVEGDnltisASCYTPRADSFHIFR 267
Cdd:cd11490 161 TALYTVAGGLAAVIYTDALQTIIMVIGALILMGYSFAEVGGFEALLEKYFQAIPSIRSPN-----STCGIPREDAFHIFR 235

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 268 DAVTGDIPWPGIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACVV 347
Cdd:cd11490 236 DPVTSDLPWPGVLLGMSIPSLWYWCTDQVIVQRSLAAKNLSHAKGGSLLAAYLKVLPLFMMVIPGMISRILFPDQVACAD 315

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 348 PSECVKHCGVDVGCTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGR 427
Cdd:cd11490 316 PEVCKEICGNPSGCSDIAYPKLVMELLPTGLRGLMMAVMLAALMSSLTSIFNSASTIFTMDLWRHIRPRASEWELMIVGR 395

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 428 IFVLLLTVVSIVWVPLVQVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITEFAYG 507
Cdd:cd11490 396 VFVLVLVVVSILWIPLVQASQGGQLFIYIQSISSYLQPPVAVVFIAGCFWKRTNEKGAFWGLMVGLAVGLTRMVLDFIYV 475

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 508 TGSCLAPSNCPKIICGVHYLYFSIVLFFGSMLVTLGISLLTKPIPDVHLYRLCWVLRnsteeridIDAEEKSQEetddgv 587
Cdd:cd11490 476 TPQCDQPDTRPDIVKYVHYLYFSMILTILTLVVVVCVSLATEPPSKEMISRLTWFTR--------FDAVVESEE------ 541

                       570       580       590       600       610       620       630
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 14140236 588 eedypeksrgcLKKAYDLFCGLQKGPKLTKEEEEALSKKLTDTSERPSWRTIVNINAILLLAVVVFIHGYYA 659
Cdd:cd11490 542 -----------LKKAILWLCGMEKQTEKSSSSPAPPEAAMVSLEEEPLMKHVLNANLIICVSVAVFLWAYFA 602
SLC5sbd_SGLT5 cd11489
Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is ...
 27-659 0e+00

Na(+)/glucose cotransporter SGLT5 and related proteins; solute-binding domain; Human SGLT5 is a glucose transporter, which also transports galactose. It is encoded by the SLC5A10 gene, and is exclusively expressed in the renal cortex. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212058  Cd Length: 604  Bit Score: 689.37  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  27 ADISVIVIYFLVVMAVGLWAMLKTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSS 106
Cdd:cd11489   3 ADIIVIGVYFALNVAVGIWSSCRVSRNTVSGYFLAGRDMAWWPIGASLFASSEGSGLFIGLAGTGAAGGIAVAGFEWNAT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 107 VMLLILGWIFVPIYIKSGVMTMPEYLKKRFGGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLA 186
Cdd:cd11489  83 YALLALAWVFVPVYISSGIVTMPEYLQRRFGGERIRMYLSVLSLLLSVFTKISTDLYSGALFVQVCLGWNLYLSTVLMLV 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 187 MTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEKYVNATPSvvegdNLTISASCYTPRADSFHIF 266
Cdd:cd11489 163 VTALYTIAGGLAAVIYTDALQTLIMVIGAVILTIKAFNQIGGYSNLEEAYLQAVPS-----KIIPNTTCHLPRADAMHLF 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 267 RDAVTGDIPWPGIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACV 346
Cdd:cd11489 238 RDPVTGDLPWTGMTFGLTIMATWYWCTDQVIVQRSLSARSLSHAKGGSILASYLKMLPMGLIIMPGMISRALFPDDVACV 317

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 347 VPSECVKHCGVDVGCTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAG 426
Cdd:cd11489 318 DPEECLRVCGAEVGCSNIAYPKLVMELMPSGLRGLMIAVMMAALMSSLTSIFNSSSTLFTMDIWRRLRPGASERELLLVG 397

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 427 RIFVLLLTVVSIVWVPLVQVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITEFAY 506
Cdd:cd11489 398 RLVTVILVGVSVVWIPILQSSNSGQLYIYIQSVTSYLAPPVTAVFVLAVFWRRANEQGAFWGLMAGLVVGLTRMVLEFAH 477

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 507 GTGSCLAPSNCPKIICGVHYLYFSIVLFFGSMLVTLGISLLTKPIPDVHLYRLC-WVLRNSTEerididaeeksqEETDD 585
Cdd:cd11489 478 PAPRCGVPDTRPSVLRSMHYLHFAVALCALSGAVVVAGSLLTPPPQSVQIRNLTwWTLAQDTP------------LGIKL 545

                       570       580       590       600       610       620       630
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 14140236 586 GVEEDYPEKSRGCLKKAYDLFCGLqkgpkltkeeeealsKKLTDTSERPSWRTIVNINAILLLAVVVFIHGYYA 659
Cdd:cd11489 546 GDGQTLSRRTDGCESVRFASGTPP---------------PIIHSTTEHPFWARVCGVNAILLMCVNIFFYAYFA 604
SLC5sbd_SMIT cd11491
Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT ...
 28-566 0e+00

Na(+)/myo-inositol cotransporter SMIT and related proteins; solute-binding domain; Human SMIT is a high-affinity myo-inositol transporter, and is expressed in brain, heart, kidney, and lung. Inhibition of myo-inositol uptake, through down-regulation of SMIT, may be a common mechanism of action of mood stabilizers, including lithium, carbamazepine, and valproate. SMIT is encoded by the SLC5A3 gene, which is a candidate gene for pathogenesis of nervous system dysfunction in Down syndrome (DS). The SNP, 21q22 near SLC5A3-MRPS6-KCNE2, has been associated with coronary heart disease, cardiovascular disease, and myocardial infarction. SMIT may also be involved in the pathogeneisis of congenital cataract. SMIT also plays roles in osteogenesis, bone formation, and bone mineral density determination. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271382  Cd Length: 609  Bit Score: 616.11  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  28 DISVIVIYFLVVMAVGLWAMLKTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSV 107
Cdd:cd11491   1 DIAVVALYFILVMCIGIYAMWKSNRSTVSGYFLAGRSMTWLPVGASLFASNIGSEHFIGLAGSGAAAGFAVGAFEFNALI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 108 MLLILGWIFVPIYIKSGVMTMPEYLKKRFGGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAM 187
Cdd:cd11491  81 LLQLLGWVFIPVYIRSGVYTLPEYLSKRFGGHRIQVYLAALSLILYIFTKISVNLYSGALFIQEALGWNLYVSIILLLGL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 188 TAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEKYVNATPSV----VEGDNLTISASCYTPRADSF 263
Cdd:cd11491 161 TALLTVTGGLAAVIYTDTLQAFLMIIGALTLMIISMMEIGGFEGVKSRYMLASPNVtsilLTYNLSNTNSCCVHPKKDAF 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 264 HIFRDAVTGDIPWPGIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMV 343
Cdd:cd11491 241 KLLRDPTDEDVPWPGFILGQTPASIWYWCADQVIVQRVLAAKSLSHAQGATLMAGFIKLLPLFIIVIPGMISRILFPDDI 320

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 344 ACVVPSECVKHCGVDVGCTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELL 423
Cdd:cd11491 321 ACINPEHCMQVCGSRAGCSNIAYPRLVMKIMPSGLRGLMMAVMIAALMSDLTSIFNSASTLFTLDVYKLIRKKASSRELM 400

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 424 IAGRIFVLLLTVVSIVWVPLVQVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITE 503
Cdd:cd11491 401 IVGRIFVAVMVVISIAWIPVIQEMQGGQLYLYIQEVAAYLTPPVASLYLLAIFWKRTTEQGAFYGGMAGFVLGAVRLILA 480

                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 14140236 504 FAYGTGSCLAPSNCPKIICGVHYLYFSIVLFFGSMLVTLGISLLTKPIPDVHLYRLCWVLRNS 566
Cdd:cd11491 481 FAYRAPECGQPDNRPGIIKDIHYMYFATALFWITGLITVIVSLLTPPPTKENIRTTTFWTKKS 543
SSF pfam00474
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ...
 58-492 2.23e-162

Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.


Pssm-ID: 109527 [Multi-domain]  Cd Length: 406  Bit Score: 471.82  E-value: 2.23e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236    58 FFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTMPEYLKKRFG 137
Cdd:pfam00474   1 YFLAGRSMTGFVNGLSLAASYMSAASFVGLAGAGAASGLAGGLYAIGALVGVWLLLWLFAPRLRNLGAYTMPDYLRKRFG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236   138 GERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFI 217
Cdd:pfam00474  81 GKRILVYLSALSLLLYFFTYMSVQIVGGARLIELALGLNYYTAVLLLGALTAIYTFFGGFLAVSWTDTIQAVLMLFGTII 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236   218 LMGFAFNEVGGYESFTEKYVNATPSVVegDNLTisascytprADSFHIFRDAVTGDIPWPGIIFGMPITalwywctnQVI 297
Cdd:pfam00474 161 LMIIVFHEVGGYSSAVEKYMTADPNGV--DLYT---------PDGLHILRDPLTGLSLWPGLVLGTTGL--------PHI 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236   298 VQRCLCGKDmshvkAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACVVPsecvKHCGVDVGCTNYAYPTMVLELMPQG 377
Cdd:pfam00474 222 LQRCLAAKD-----AKCIRCGVLILTPMFIIVMPGMISRGLFAIALAGANP----RACGTVVGCSNIAYPTLAVKLGPPG 292

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236   378 LRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGRIFVLLLTVVSIVWVPLVQVSQNGqLIHYTE 457
Cdd:pfam00474 293 LAGIMLAVMLAAIMSTLTSQLLSSSSAFTHDLYKNIRRKASATEKELVGRSRIIVLVVISLAILLAVQPAQMG-IAFLVQ 371

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 14140236   458 SISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVG 492
Cdd:pfam00474 372 LAFAGLGSAFLPVILLAIFWKRVNEQGALWGMIIG 406
sss TIGR00813
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ...
 61-492 7.77e-157

transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273282 [Multi-domain]  Cd Length: 407  Bit Score: 457.92  E-value: 7.77e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236    61 AGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTMPEYLKKRFGGeR 140
Cdd:TIGR00813   1 AGRSLGGWVVAASLFASYISASQFLGLPGAIYAYGFAIGFYELGALVLLIILGWLFVPIFINNGAYTMPEYLEKRFGK-R 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236   141 LQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMG 220
Cdd:TIGR00813  80 ILRGLSVLSLILYIFLYMSVDLFSGALLIELITGLDLYLSLLLLGAITILYTVFGGLKAVVWTDTIQAVIMILGTFILPV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236   221 FAFNEVGGYESFTEKYVNATPSVvegdnltisascyTPRADSFHIFRDAVTGDIPWPGIIFGMPITALWYWcTNQVIVQR 300
Cdd:TIGR00813 160 FAFSEVGGLGTFVEKASQAAPTN-------------PSPDDLYDFFRDPSTSDLPWGAGVFGLPHVALWYW-TNQVIVQR 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236   301 CLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMvacvVPSEcvkhCGVDVGCTNYAYPTMVLELMPQGLRG 380
Cdd:TIGR00813 226 CLAAKSAKHAKKGCLISGVLKLLPMFGAVLPGLIARALYTDI----DPAL----AGAVNQNSDQAYPLLVQELMPPGLAG 297

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236   381 LMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGRIFVLLLTVVSIVWVplVQVSQNGQLIHYTESIS 460
Cdd:TIGR00813 298 LFLAAILAAVMSTLSSQLNSASTVFTMDLYKKIIRPNASGEKKIVMRGRIAVLVAAVIAGF--VAAAQGGQVLQYVQEAF 375

                         410       420       430
                  ....*....|....*....|....*....|..
gi 14140236   461 SYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVG 492
Cdd:TIGR00813 376 GGLGAPFLPVFLLGIFWKRMNAKGALAGMIAG 407
YidK COG4146
Uncharacterized membrane permease YidK, sodium:solute symporter family [General function ...
 25-499 3.25e-148

Uncharacterized membrane permease YidK, sodium:solute symporter family [General function prediction only];


Pssm-ID: 443317 [Multi-domain]  Cd Length: 444  Bit Score: 437.27  E-value: 3.25e-148
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  25 NAADISVIVIYFLVVMAVGLWAMLKTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWT 104
Cdd:COG4146   4 STLDYIVFLLYFLLVAGIGYWVSRKKKEKTSEDYFLAGRSLTWWVIGASLIATNISAEQLIGLNGSGYATGLAVAAYEWM 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 105 SSVMLLILGWIFVPIYIKSGVMTMPEYLKKRFgGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFIL 184
Cdd:COG4146  84 AAIALIILALFFLPFYLKSGIYTMPEFLEKRY-DRRTRTILSILFLVSYVFVNLPSVLYAGALALNTIFGVPLWISVIGL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 185 LAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGyesftekyvnatPSVVEG-DNLTISAscytprADSF 263
Cdd:COG4146 163 GIIAGIYTIFGGLKAVAYTDVIQGIGLIIGGLLITVLGLDAVGD------------GSVLAGwSALLKVP------PEKF 224

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 264 HIFRDAVTGDIPWPGIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMV 343
Cdd:COG4146 225 NMIGPADDPDLPWLGIFTGMPILNLFYWGTNQYIVQRALGAKNLKEAQKGVLFAGFLKLLIPFIVVLPGIIAFVLFPDGL 304

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 344 AcvvpsecvkhcgvdvgCTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKM-RKQASEKEL 422
Cdd:COG4146 305 D----------------NPDQAYPTLVKNLLPVGLKGLVAAALFAAIMSSLASALNSSSTLFTLDIYKKYfNPNASEKQL 368

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 14140236 423 LIAGRIFVLLLTVVSIVWVPLVQVSqnGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIR 499
Cdd:COG4146 369 VKVGRIATVVLAVIAILIAPLIGNA--DGLFQYIQEVTGFFSPPILAVFLLGLFWKRVTAKAAKVALIAGIVLSILL 443
PutP COG0591
Na+/proline symporter [Amino acid transport and metabolism];
25-553 2.66e-88

Na+/proline symporter [Amino acid transport and metabolism];


Pssm-ID: 440356 [Multi-domain]  Cd Length: 476  Bit Score: 283.63  E-value: 2.66e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  25 NAADISVIVIYFLVVMAVGLWAMLKTNrgTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWT 104
Cdd:COG0591   2 STLDLIIIILYLLLLLGIGLYASRRTK--SLEDYFLAGRSLGWWVLALSLGATWLSAWTFLGVPGLAYAYGLSALWYALG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 105 SSVMLLILGWIFVPIYIKSGVMTMPEYLKKRFGgERLQVYLSILSLFICVvLLISADIFAGAIFIKLALGLDLYLAIFIL 184
Cdd:COG0591  80 YALGALLLALFFAPRLRRLGALTIPEFLEKRFG-RGLRLLAAIIILLFLL-GYLAAQLVALGKLLEALFGIPYWLGILIG 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 185 LAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEKyvnatpsvvegdnltisascyTPRADSFH 264
Cdd:COG0591 158 ALIVLLYTVLGGLRAVAWTDVLQGILMLVGLILLLIVALSALGGFGELFAA---------------------LPAPGLLS 216

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 265 IFRDAvtgDIPWPGIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVA 344
Cdd:COG0591 217 LFPGL---GFTGWLAFLGLFLAIGLGYFGQPHIVQRFLAAKSEKEARKAALIGGLLYLLFYLLAALIGLLARALFPDLPL 293

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 345 cvvpsecvkhcgvdvGCTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKM-RKQASEKELL 423
Cdd:COG0591 294 ---------------ADPDLALPLLILELLPPGLAGLLLAAILAAAMSTADSQLLAASSVFTRDIYKPFiKPKASDKQLL 358

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 424 IAGRIFVLLLTVVSIVWVplvqVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITE 503
Cdd:COG0591 359 RVSRLAVLVVGLLALLLA----LLFPSSILDLVLLAWGGLGAALLPPLLLGLFWKRATKAGALAGMIAGLVVVLLWKLLG 434

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|
gi 14140236 504 FAygtgsclapsncpkiICGVHYLYFSIVLFFGSMLVTLGISLLTKPIPD 553
Cdd:COG0591 435 GP---------------LGPFGWLYPILPGLLVSLLVFVVVSLLTKPPSE 469
SLC5sbd_u2 cd11478
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
 28-553 3.06e-87

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271372  Cd Length: 496  Bit Score: 281.48  E-value: 3.06e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  28 DISVIVIYFLVVMAVGLWAMLKTNrgTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSV 107
Cdd:cd11478   2 DYLIVAVYFVFVLGIGFYLKRKVK--TSEDFFLSGRSLPAWITGLAFISANLGALEIVGMSANGAQYGIATVHFYWIGAI 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 108 --MLLiLGWIFVPIYIKSGVMTMPEYLKKRFGGE-RLqvyLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFIL 184
Cdd:cd11478  80 paMVF-LGIVMMPFYYGSKVRSVPEYLKLRFNKStRL---LNAVSFAVMTILMSGINLYALALVLNVLLGWPLWLSIILS 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 185 LAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEKYVNATPsvvegdnltisascytPRADSFH 264
Cdd:cd11478 156 AAIVLAYTTLGGLTSAIYNEVLQFFLIVAGLIPLVIIGLIKVGGWDGLSEKIDANGP----------------PGWNGLS 219

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 265 IFRDAVTGDIPW---PGIIFGMP-ITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYt 340
Cdd:cd11478 220 WGPQGSQSTNPMgvnLGLVFGLGfVLSFGYWTTNFLEVQRAMAAKDLSAARRTPLIAAFPKMFIPFLVILPGLIALVLV- 298

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 341 dmvacvvpSECVKHCGVDvgcTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLY-TKMRKQASE 419
Cdd:cd11478 299 --------PELGASGGLD---YNQALPYLMAKYLPPGLLGLGITALLAAFMSGMAGNVSAFNTVFTYDIYqTYIVKDAPD 367

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 420 KELLIAGRIFVLLLTVVSIVWVPLvqVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIR 499
Cdd:cd11478 368 KHYLKVGRIATVVGVLISIGTAYI--ASSFNNIMDYLQLLFSFFNAPLFATFLLGMFWKRATPWGGFWGLLAGTASAIVL 445

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|....*
gi 14140236 500 MI-TEFAYGTGSCLAPSNcpkiicgvhyLYFSIVLFFGSMLVTLGISLLTKPIPD 553
Cdd:cd11478 446 YGlYELGLIVYHSDMAPN----------FYGAWWAFVVCFVVTVLVSLLTKPKPE 490
SLC5sbd_vSGLT cd10325
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute ...
 31-498 1.28e-81

Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; vSGLT transports D-galactose, D-glucose, and alpha-D-fucose, with a sugar specificity in the order of D-galactose >D-fucose >D-glucose. It transports one Na+ ion for each sugar molecule, and appears to function as a monomer. vSGLT has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271360  Cd Length: 523  Bit Score: 267.63  E-value: 1.28e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  31 VIVIYFLVVMAVGLWAML--KTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVM 108
Cdd:cd10325   2 IFIVYVILIIGLGLWVSRekKGGEKDATDYFLAGKSLPWWAIGASLIAANISAEQFIGMSGSGFAIGLAIASYEWMAAIT 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 109 LLILGWIFVPIYIKSGVMTMPEYLKKRFGGeRLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMT 188
Cdd:cd10325  82 LIIVAKFFLPIFLKNGIYTMPQFLEERYDG-RVRTIMAVFWLLLYVFVNLTSVLYLGALAIETITGIPLTYSIIGLALFA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 189 AVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYEsftekyvnatpSVVEGDNLTISAScytprADSFHIFRD 268
Cdd:cd10325 161 AAYSIYGGLKAVAWTDVIQVVFLVLGGLVTTYIALSLLGGGE-----------GVFAGFTLLAAEA-----PEHFHMILD 224

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 269 AVTG-----DIPWPGIIF-GMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDM 342
Cdd:cd10325 225 KSNPedaykDLPGIAVLLgGLWVANLSYWGFNQYIIQRALAAKSLSEAQKGIVFAAFLKLLIPFIVVIPGIAAYVLASNL 304

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 343 VACVVPSECVKhcgvdvgctNYAYPTMvLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMR-KQASEKE 421
Cdd:cd10325 305 LLPAATGIEKP---------DQAYPWL-LRNLPTGLKGLVFAALTAAIVSSLASMLNSISTIFTMDIYKKYIpKKASEKQ 374

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 14140236 422 LLIAGRIFVLLLTVVSIVWVPLvqVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLI 498
Cdd:cd10325 375 LVNVGRLAAVIALIIAALIAPP--LLGLDQAFQYIQEYTGFISPGILAIFLLGLFWKRATSAGALVAAILSIVLSAL 449
SLC5sbd cd10322
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ...
 28-509 2.80e-75

Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.


Pssm-ID: 271357 [Multi-domain]  Cd Length: 454  Bit Score: 248.62  E-value: 2.80e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  28 DISVIVIYFLVVMAVGLWAMLKTNrgTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSV 107
Cdd:cd10322   2 DLIIVVVYLALLLGIGLYASKKVK--SSEDFFLAGRSLGPWLLAGTLAATWISAGSFVGVAGLAYTYGLSAIWYILGAAL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 108 MLLILGWIFVPIYIKSGVMTMPEYLKKRFGGERLQVYLSILSlFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAM 187
Cdd:cd10322  80 GALLLALFLAPRLRRLGKTTIPETILERYYSKGLRLLVAIII-IIALIPYLALQLIGGGYILSTLLGIPYTVAVIIAAVI 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 188 TAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYesFTEKYVNATPSvvegdnltisascytpradsfhIFR 267
Cdd:cd10322 159 VILYTVFGGMRAVAWTDVIQGIVMLIGVLVAAIFILSKVGGG--GFSALAAALPA----------------------LLL 214

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 268 DAVTGDIPWPGIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVAcvv 347
Cdd:cd10322 215 ALGPGGGLGWSTILSLILLTGLGVLALPQVFQRILAAKDEKTARRAFLLAGLLLLLIGFLVALIGLAARALFPDLEN--- 291

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 348 psecvkhcgvdvgcTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKM-RKQASEKELLIAG 426
Cdd:cd10322 292 --------------PDLALPTLINSLLPPGLAGLVLAGLLAAAMSTADSLLLAASTLFTRDIYKPLiNPKASDKKLLRVS 357

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 427 RIFVLLLTVVSIVWVPLVQvsqngQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITEFAY 506
Cdd:cd10322 358 RIAVVVVGVLALLLALLPP-----SILLLLSLAAGLLAAALFPPLLGGLFWKRATKAGAIAGIIVGLIVTLVWLLLPLAS 432


                ...
gi 14140236 507 GTG 509
Cdd:cd10322 433 PLG 435
SLC5sbd_YidK cd10328
uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; ...
 36-545 4.85e-73

uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Uncharacterized subfamily of the solute binding domain of the solute carrier 5 (SLC5) transporter family (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily includes the uncharacterized Escherichia coli YidK protein, and belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271362  Cd Length: 472  Bit Score: 243.21  E-value: 4.85e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  36 FLVVMA-VGLWAMLKTNRGTIG---GFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLI 111
Cdd:cd10328   1 FLLFTAlVALISWYKTRGDDLSssdGYFLAGRSLTGVVIAGSLLLTNLSTEQLVGLNGQAYALGMSVMAWEVTAAIALII 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 112 LGWIFVPIYIKSGVMTMPEYLKKRFGgERLQVYLSILSLFICVVLLISADIFAGAIF------IKLALGLDLYLAIFILL 185
Cdd:cd10328  81 LALVFLPRYLKGGITTIPEFLEERYD-ETTRRIVSILFLLGYVVILLPIVLYSGALAlnslfdVSELLGISYFQALWLLV 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 186 AMTAV----YTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGyesftekyvnatPSVVEGDNLTISAScyTPRAD 261
Cdd:cd10328 160 WLIGIigaiYAIFGGLKAVAVSDTINGVGLLIGGLLIPILGLIALGD------------GSFLAGLDTLLTAH--PEKLN 225

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 262 SFhifrDAVTGDIPWPGIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTD 341
Cdd:cd10328 226 AI----GGADSPVPFSTLFTGMLLVNLFYWCTNQAIIQRALAAKNLKEGQKGVLLAGFFKLLVPLILVLPGIIAFHLYGD 301

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 342 mvacvvpsecvkhcgvDVGCTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKM-RKQASEK 420
Cdd:cd10328 302 ----------------GLENADMAYPTLVADVLPKWLSGFFAAVLFGAILSSFNSALNSAATLFSLDIYKPIiNKNATDK 365

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 421 ELLIAGRIFVLLLTVVSIVWVPLVQVSQNGqLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAfwglMVGLAMGLIrm 500
Cdd:cd10328 366 QLVKVGKIFGIVLALISMIIAPFIAYAPEG-LFNYLQQFNGFFSIPILAIVLVGFFTKRVPALAA----KIALIFGVI-- 438

                       490       500       510       520
                ....*....|....*....|....*....|....*....|....*
gi 14140236 501 itefAYGTGSCLAPSNcpkiicgVHYLYFSIVLFFGSMLVTLGIS 545
Cdd:cd10328 439 ----LYALLQFVFLVP-------IHFLHVLAILFVICVAIMLIIG 472
PRK10484 PRK10484
putative transporter; Provisional
 32-547 4.13e-69

putative transporter; Provisional


Pssm-ID: 236699 [Multi-domain]  Cd Length: 523  Bit Score: 234.01  E-value: 4.13e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236   32 IVIYFLVVMAVGLWAMLKTNR---GTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVM 108
Cdd:PRK10484   4 ILSFLGFTLLVAVISWWKTRKtdtSSSDGYFLAGRSLTGPVIAGSLLLTNLSTEQLVGLNGQAYASGMSVMAWEVTAAIA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  109 LLILGWIFVPIYIKSGVMTMPEYLKKRFGGERLQVyLSILSLFICVVLLISADIFAGAI-----F-IKLALGLDLYLAIF 182
Cdd:PRK10484  84 LIILALIFLPRYLKSGITTIPDFLEERYDKTTRRI-VSILFLIGYVVSFLPIVLYSGALalnslFhVSELLGISYGAAIW 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  183 ILLAMT----AVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGyesftekyvnatpsvveGDNLTISASCYTP 258
Cdd:PRK10484 163 LLVWLIgiigAIYAVFGGLKAVAVSDTINGIGLLIGGLLVPVFGLIALGD-----------------GSFMQGLEQLTTV 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  259 RADSFHIFRDAvTGDIPWPGIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRIL 338
Cdd:PRK10484 226 HPEKLNSIGGA-TDPVPFPTLFTGLILVNLFYWCTNQSIVQRALGAKNLAEGQKGALLAAFFKLLGPLILVLPGIIAFHL 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  339 YTDMVACvvpsecvkhcgvdvgcTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLY-TKMRKQA 417
Cdd:PRK10484 305 YGDGLPN----------------ADMAYPTLVNDVLPVPLVGFFAAVLFGAILSTFNGFLNSASTLFSLDIYkPIINPNA 368

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  418 SEKELLIAGRIFVLLLTVVSIVWVPLVQVSQNGqLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVG-LAMG 496
Cdd:PRK10484 369 SEKQLVKVGKKFGFVLAIISMIVAPLIANAPQG-LYSYLQQLNGIYNVPILAIIIVGFFTKRVPALAAKVALGFGiILYI 447

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|.
gi 14140236  497 LIRMITEFaygtgsclapsncpkiicGVHYLYFSIVLFFGSMLVTLGISLL 547
Cdd:PRK10484 448 IINFVLKF------------------DIHFLYVLAILFVINVVVMLIIGKI 480
SLC5sbd_NIS-like_u2 cd11494
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ...
 28-498 3.96e-66

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters, SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271385 [Multi-domain]  Cd Length: 473  Bit Score: 224.79  E-value: 3.96e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  28 DISVIVIYFLVVMAVGLWamlkTNRGT--IGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTS 105
Cdd:cd11494   2 DWIVLVGYLLGILVYGVY----KGRGQknQEDYFLGGRSMPWWPIGLSIMATQASAITFLSAPGQAYSDGMRFVQYYFGL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 106 SVMLLILGWIFVPIYIKSGVMTMPEYLKKRFGgerLQVYLSILSLFICVVLL-ISADIFAGAIFIKLALGLDLYLAIFIL 184
Cdd:cd11494  78 PLAMIFLCITFVPVFYKLKVYTAYEYLERRFG---LKTRLLTSILFLISRGLaTGVTIYAPAIILSTILGWSLWLTILLI 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 185 LAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNE--VGGYESFTEKyvnatpsvVEGDNLTISAScytpradS 262
Cdd:cd11494 155 GGITIIYTVLGGIKAVIWTDVIQMVIIWAGLFIAFGLLLKLlpVGFVDALLVA--------GKSGRLNALDF-------S 219

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 263 FHIFRDAVTgdipWPGIIfGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDM 342
Cdd:cd11494 220 FDLSDTYTF----WSGLI-GGFFLYLSYFGTDQSQVQRYLTAKSIKEARKSLLLNGFLKFPMQFFILLIGVLVFVFYQFN 294

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 343 VACVVPSECVkhcgVDVGCTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKM-RKQASEKE 421
Cdd:cd11494 295 PFPVSFNPAE----DETKDTNYIFLRFVLNYLPPGVIGLLIAAIFAAAMSSIDSALNSLATVTVIDIYRRFfKKDASDEH 370

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 14140236 422 LLIAGRIFVLLLTVVSIvwVPLVQVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLI 498
Cdd:cd11494 371 YLKVSRLLTVFWGLLAI--VFALFAGLAGSLIEAVNKLGSLFYGPILGVFLLAFFTKKANGKGVFAGAILGVIVVIV 445
SLC5sbd_u1 cd11477
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
 28-558 2.64e-60

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271371  Cd Length: 493  Bit Score: 209.74  E-value: 2.64e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  28 DISVIVIYFLVVMAVGLWAMLKTNRGTiGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSV 107
Cdd:cd11477   2 DWLVIALYFLLMLGIGLWFSKRASKST-SDFFLGGRKLPWWLAGISMAATTFSADTFVAVAGIAYTYGIAGNWIWWLWAV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 108 MLLILGWIFVPIYIKSGVMT----MPEYLKKRFGGeRLQVYLSILSLFIcVVLLISADIFAGAIFI-KLALGLDLYLAIF 182
Cdd:cd11477  81 AGLIGAFVFARRWRRLRVLTdgefPEERYGGRYGA-PLRQFYAVYFALL-SNVDILAWVFLAAIKVsAVFGPWDPWLTIL 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 183 ILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEKyvnatpsvVEGDNLTISASCYTPRADS 262
Cdd:cd11477 159 ILGLITLIYTVIGGLWAVVVTDVVQFVIAMAASIAVAVLALNAVGGPGGLFAQ--------LPEGHLDLFGSGLGASGFY 230

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 263 FHIFRdavtgdIPWPGIIFGMPITALWYwctnqvIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDM 342
Cdd:cd11477 231 ITFFF------ILFFGWYPLSYSGGGWY------LAQRYLSAKSEKAAKAAAWLFAALYLVRPWPWMLPALAALVLYPDL 298

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 343 VACVVPSEcvkhcgvdvgctnYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTK-MRKQASEKE 421
Cdd:cd11477 299 DDPEADFE-------------LAYPMMIKEYLPAGLLGLVLAGLLAATMSTVSTHLNWGAAYLVNDIYKRfIKPNASEKH 365

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 422 LLIAGRIFVLLLTVVSIVWVplVQVSQNGQLIHYTESISSYLGPPIAAVFVLAifckRVNEQGAFWGLMVGLAMGLIrmi 501
Cdd:cd11477 366 LLKVGRLATVLFGLLSIVVA--LASDSIGGAFWIVLALGAGLGGPLILPWLWW----RFNAWTEIWAMIASIIVGLV--- 436

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 14140236 502 tefaygtgsclAPSNCPKIICGVHYLYFSIVLFFGSMLVTLGISLLTKPIPDVHLYR 558
Cdd:cd11477 437 -----------VSVLLKVFGLPEDFLFSFLVPVLLSLVVWLAVTLLTPPTDEETLVA 482
SLC5sbd_NIS-like_u3 cd11495
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ...
 26-494 1.29e-47

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271386 [Multi-domain]  Cd Length: 473  Bit Score: 174.27  E-value: 1.29e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  26 AADISVIVIYFLVVMAVGLWAMLKTNRGTigGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTS 105
Cdd:cd11495   3 WLDYLVLVIYLLAMLGIGLYFSKKQKSTD--DYFKGGGRIPWWAAGLSIFATTLSSITFLAIPGKAYATDWNYFVGSLSI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 106 SVMLLILGWIFVPIYIKSGVMTMPEYLKKRFgGERLQVYLSIL-SLF----ICVVLLISadifagAIFIKLALGLDLYLA 180
Cdd:cd11495  81 IIAAPLAAYFFVPFFRRLNVTSAYEYLEKRF-GPWARVYGSLLfILFqlgrMGIVLYLP------ALALSAVTGINPYII 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 181 IFILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGyeSFTEKYVNAtpsvVEGDNLTISASCYTPRA 260
Cdd:cd11495 154 IILMGVLCIIYTVLGGIEAVIWTDVIQGVVLLGGALLCLIILLFSIPG--GFGEVFDIA----IANGKFSLGDFSFSLTE 227

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 261 DSFhifrdavtgdipwPGIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYT 340
Cdd:cd11495 228 STI-------------WVIFIGGIFNNLQSYTSDQDVVQRYLTTKSIKEAKKSLWTNALLALPVALLFFGIGTALYVFYQ 294

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 341 DMVAcvVPSECVKhcgvdvgcTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEK 420
Cdd:cd11495 295 QHPE--LLPAGIN--------GDAVFPYFIVTQLPVGVAGLIIAAIFAAAMSTISSSLNSVATCITTDFYKRLSPDPSDK 364

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 14140236 421 ELLIAGRIFVLLLTVVSIVWVPLVQVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLA 494
Cdd:cd11495 365 QYLKVARLITLLVGLLGTLVALYLANAGVKSLLDAFNTLTGLFGGGLAGLFLLGIFTKRANAKGALVGIIVSII 438
SLC5sbd_NIS-like cd10326
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ...
 28-507 2.08e-45

Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and 2. SMCT1(the product of the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (product of the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271361 [Multi-domain]  Cd Length: 472  Bit Score: 168.12  E-value: 2.08e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  28 DISVIVIYFLVVMAVGLWAMLKtnRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSV 107
Cdd:cd10326   1 DWAVVVVYFLILLAISYYTSRR--NADNDDFFLGNRQSPWYLVAFSMIGTSLSGVTFVSVPGEVGGSGFTYLQMVLGFLL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 108 MLLILGWIFVPIYIKSGVMTMPEYLKKRFGGE--RLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILL 185
Cdd:cd10326  79 GYLIIAFVLLPLYYRLNLTSIYEYLEDRFGVSsrKTGAVFFLLSRILGAGIRLYLVALVLQQFLFDSLGIPFWLTVLITG 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 186 AMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGyeSFTEkyvnatpsvvegdnlTISASCYTPRADSFHi 265
Cdd:cd10326 159 LLIWLYTFRGGIKTVVWTDTLQTVFLLVGLVLTIIIISNSLGL--GFGE---------------AISAAGESGYSRIFN- 220

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 266 FRDAVTGDIPWPGIIFGMpITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMisrILYTDMVAC 345
Cdd:cd10326 221 FDDDNSRRTFWKQFLGGI-FITIAMTGLDQDMMQRNLSCKNLKDAQKNMLTFGVILVPVNLLFLLLGV---LLYTYAQKN 296

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 346 VVPsecvkhcgVDVGCTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRK---QASEKEL 422
Cdd:cd10326 297 GIA--------LPAKDSDQLFPYFALNGLPPGVSGLFVAGIIAAAMSSADSALTALTTSFCVDILNRFKRkseKKSERKY 368

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 423 LIAGRIFVLLLTVVSIVWvplvqVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQ--GAFWGLMVGLAMGLIRM 500
Cdd:cd10326 369 VHIAFSLTFVLGILVFGS-----ASNSGSLIDAIFKVAGYTYGPLLGLFAFGLFTKRAVKDkwVPLVGLLAPVLSYLLVS 443


                ....*..
gi 14140236 501 ITEFAYG 507
Cdd:cd10326 444 NSEGFFG 450
SLC5sbd_PutP cd11475
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli ...
 29-498 3.56e-44

Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli PutP catalyzes the Na+-coupled uptake of proline with a stoichiometry of 1:1. The putP gene is part of the put operon; this operon in addition encodes a proline dehydrogenase, allowing the use of proline as a source of nitrogen and/or carbon. This subfamily also includes the Bacillus subtilis Na+/proline cotransporter (OpuE) which has an osmoprotective instead of catabolic role. Expression of the opuE gene is under osmotic control and different sigma factors contribute to its regulation; it is also a putative CcpA-activated gene. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271369  Cd Length: 464  Bit Score: 164.60  E-value: 3.56e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  29 ISVIVIYFLVVMAVGLWAMLKTNrgTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVtfeWTSSVM 108
Cdd:cd11475   1 LITFIVYLLLMLGIGIYSYRKTK--TLEDYFLGGRSLGPWVTALSAGASDMSGWLLLGLPGAAYASGLSAI---WIAIGL 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 109 LL--ILGWIFVPIYI-----KSGVMTMPEYLKKRFGGER--LQVyLSILSLFICVVLLISADIFAGAIFIKLALGLDLYL 179
Cdd:cd11475  76 ILgaYLNWLFVAKRLrryteKNDSITLPDYLENRFRDKSklLRI-LSALIILIFFTIYAAAQLVAGGKLFESLFGIDYST 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 180 AIFILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEKYVNATPsvvegdnltisascytpr 259
Cdd:cd11475 155 GLLIGAVVVVAYTFLGGFLAVSWTDFFQGLLMLLALVLVPIVALAALGGLSGLVAALAAIDP------------------ 216

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 260 aDSFHIFRDAvTGDIPWPGII---------FGMPitalwywctnQVIVqRCLCGKDMSHVKAACIMCAYLKLLPMFLMVM 330
Cdd:cd11475 217 -GLLSPFGGD-LGAGGLLAIIsllawglgyFGQP----------HILV-RFMAIRSPKEIKKARRIAMVWMILFLLGAVL 283

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 331 PGMISRILYTDMVAcvVPSEcvkhcgvdvgctnYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLY 410
Cdd:cd11475 284 VGLLGRALFPDGLL--GDPE-------------TVFPVLAQELFPPWLAGILLAAILAAIMSTADSQLLVCSSALTEDLY 348

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 411 TKM-RKQASEKELLIAGRIFVLLLTVVSiVWVPLVQVSQNGQLIHYTES-ISSYLGPPIaavfVLAIFCKRVNEQGAFWG 488
Cdd:cd11475 349 KAFlRKEASDKELVWVSRLAVLVIALIA-LLIALNPPSSVFSLVSFAWAgLGAAFGPLL----LLSLYWKRTTRQGALAG 423

                       490
                ....*....|
gi 14140236 489 LMVGLAMGLI 498
Cdd:cd11475 424 MIAGAVTVVV 433
PanF COG4145
Na+/panthothenate symporter [Coenzyme transport and metabolism];
25-550 4.01e-41

Na+/panthothenate symporter [Coenzyme transport and metabolism];


Pssm-ID: 443316  Cd Length: 484  Bit Score: 156.54  E-value: 4.01e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  25 NAADISVIVIYFLVVMAVGLWAMLKTNRGT-IGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATV---- 99
Cdd:COG4145   3 NLAILIPLLIYLLLVLGIGIYASRKRSKGSfLEEYFLGSRSMGGFVLAMTLAATYTSASSFIGGPGAAYKYGLGWVllam 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 100 TFEWTSSVMLLILGWIFVPIYIKSGVMTMPEYLKKRFGGErlqvYLSILSLFICVVLLIS---ADIFAGAIFIKLALGLD 176
Cdd:COG4145  83 IQVPTAFLTLGVLGKKFAILGRKYNAVTLADWLRARYQSK----ALVLLAALLLLLFFIAfmvAQFVGGARLLETVTGIS 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 177 LYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEKYVNATPSVVEGDNltisascy 256
Cdd:COG4145 159 YTTGLLIFGVTVVLYTTIGGFRAVVLTDAIQGIIMLVGTVLLLIGVISAGGGIENIMSTLAAIDPNLVSPTG-------- 230

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 257 tprADSFhifrdavtgdIPWPGIIFGMPITALWYWCTNQVIVqRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISR 336
Cdd:COG4145 231 ---PDGF----------LPRPFVISFWILVGFGVIGLPHTAV-RCMAYKDSKSLHRAMIIGTIVVGLLMFGMHLIGVLGR 296

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 337 ILYTDMVAcvvpsecvkhcgvdvgcTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYT---KM 413
Cdd:COG4145 297 AVLPDLTV-----------------PDQVIPTLMVKVLPPFLAGIFLAGPLAAIMSTVDSLLLQASSTIVKDLYLnyiNP 359

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 414 RKQASEKELLIAGRIFVLLLTVVSIV--WVP---LVQVSQNGqlihYTESISSYLGPpiaavFVLAIFCKRVNEQGAFWG 488
Cdd:COG4145 360 KASENEKKLKRLSKLVTLVLGLIVFLlaLNPpdlIIWLNLFA----FGGLEAAFFWP-----LVLGLYWKRANATGAIAS 430

                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 14140236 489 LMVGLAMGLIRMITEFAygtgsclapsncpkiICGVHYLYFSIVLffgSMLVTLGISLLTKP 550
Cdd:COG4145 431 MLVGVASYFLLYYGNPK---------------IFGFHAIVPSLLI---SLIAFLIGSLLGKP 474
SLC5sbd_NIS-like_u1 cd11493
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ...
 28-507 1.72e-40

uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271384 [Multi-domain]  Cd Length: 479  Bit Score: 154.68  E-value: 1.72e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  28 DISVIVIYFLVVMAVGLWAMLKTNRGTigGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSV 107
Cdd:cd11493   1 DLAVIVLYLLGLPLLGLWLSGRQKSTA--DYFLGGRSMPWWAVCLSVVATETSTLTFLSIPGLAYGGDLTFLQLALGYIL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 108 MLLILGWIFVPIYIKSGVMTMPEYLKKRFGGeRLQVYLSILslFICVVLLIS-ADIFAGAIFIKLALGLDLY-----LAI 181
Cdd:cd11493  79 GRIIVAFVLLPRYFRGEVVSAYELLGQRFGG-GMQKTASVT--FLVTRLLADgVRLFAAAIPVSMILGADGValsyiASI 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 182 FILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEKYVNATPSVVEGDNLTISASCYTPRAd 261
Cdd:cd11493 156 LIISVVTLLYTYFGGIRAVVWTDVIQLVVYIGGAVAALAYLLGALPADWLQIAAAAGKFHLFDLSDLILGLTSPYTFWA- 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 262 sfhifrdAVTGdipwpGIIFGMPITAlwywcTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTD 341
Cdd:cd11493 235 -------AIIG-----GALLSMASHG-----TDQLMVQRLLACRNLRDAQKALIGSGVVVFPQFALFLLIGLLLYVYYGG 297

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 342 MVACvvpsecvkhcGVDVGCTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYT-KMRKQASEK 420
Cdd:cd11493 298 ASLA----------ALGLGSPDEVFPYFIVHELPAGLRGLLIAGILAAAMSTLSSALNSLASSTVQDLYQpWKRRRLSDE 367

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 421 ELLIAGRIFVLLLTVVSIVwVPLVQVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGL-AMGLIR 499
Cdd:cd11493 368 KLLRASRLLTLVWAVVLVG-IALLFQYTDQPVVELGLSIASFTYGGLLGVFLLGLLTRRASQRDAIAAFIVGFlVMLLLI 446


                ....*...
gi 14140236 500 MITEFAYG 507
Cdd:cd11493 447 FGVKFLGL 454
SLC5sbd_CHT cd11474
Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding ...
 29-545 2.70e-39

Na(+)- and Cl(-)-dependent choline cotransporter CHT and related proteins; solute-binding domain; Na+/choline co-transport by CHT is Cl- dependent. Human CHT (also called CHT1) is encoded by the SLC5A7 gene, and is expressed in the central nervous system. hCHT1-mediated choline uptake may be the rate-limiting step in acetylcholine synthesis, and essential for cholinergic transmission. Changes in this choline uptake in cortical neurons may contribute to Alzheimer's dementia. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271368 [Multi-domain]  Cd Length: 464  Bit Score: 150.75  E-value: 2.70e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  29 ISVIVIYFLVVMAVGLWAmlKTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFE-WTSSV 107
Cdd:cd11474   1 LIGVILYYLLILGIGLWA--SRRVKSSEDFLLAGRSLPLPVGVFTLFATWFGGETILGAAETFYEEGLGGVAQDpFGYAL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 108 MLLILGWIFVPIYIKSGVMTMPEYLKKRFGgERLQVYLSILSLfICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAM 187
Cdd:cd11474  79 CLILGGLFFAKPMRRMGLLTLGDFFRQRYG-RRVEVLLSIPAV-LSYLGWVAAQLVALGLVLSVILGLPVETGILISAAI 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 188 TAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEKYVNATPSVVEGDnltisascytPRADSFHIFR 267
Cdd:cd11474 157 VLAYTLFGGMWSVAYTDVVQLIVIFVGLLVLVPFVLTNPGGVDIASAAAAGKLRFFPWLG----------TKSDWLIWID 226

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 268 DAVT---GDIPWpgiifgmpitalwywctnQVIVQRCLCGKDMSHVKAACI----MCAYLKLLPMFLmvmpGMISRILYT 340
Cdd:cd11474 227 AWLTlglGSIPQ------------------QDVFQRVLSAKSEKTAQRLSLlagvGYLLFAIPPLLI----GLAAASIDP 284

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 341 DMVACVVPSEcvkhcgvdvgcTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLY-TKMRKQASE 419
Cdd:cd11474 285 SLTQYGLEED-----------AQLILPLLLQYLTPLWVQVLFLGALLSAVMSTADSALLAPSSVFSENIYkPPFRPKASD 353

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 420 KELLIAGRIFVLLLTVVSIVwvplvqVSQNGQLIHYTESISSYLGPPIAAV-FVLAIFCKRVNEQGAFWGLMVGLamgLI 498
Cdd:cd11474 354 RELLWVMRISVVVFGAIATL------MALTVESIYGLVELASDLVLVGLFVpLLAGLYWKRANTYGALAAIIVGL---VL 424

                       490       500       510       520
                ....*....|....*....|....*....|....*....|....*..
gi 14140236 499 RMITEFAYGTgsclAPSNCPKIICGvhyLYFSIVLFFGSMLVTLGIS 545
Cdd:cd11474 425 RLLGGELLLG----LPADIPPQLQG---FPFSTLAMVIGSLLPLAVS 464
SLC5sbd_NIS-SMVT cd11492
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ...
 27-509 1.90e-31

Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (encoded by the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (encoded by the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and -2. SMCT1(encoded by the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (encoded by the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271383 [Multi-domain]  Cd Length: 522  Bit Score: 128.76  E-value: 1.90e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  27 ADISVIVIYFLVVMAVGLW-AMLKTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSnhyVGLAGTGAAS---GVATVTFE 102
Cdd:cd11492   1 VDYVVFVAMLLISAAIGIYfGFFGGKQKTTEEYLLGGRNMSVFPVALSLIASFISG---ITLLGTPAEIyyyGTQYWLIV 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 103 WTSSVMLLILGWIFVPIYIKSGVMTMPEYLKKRFGgERLQVYLSILslFI-CVVLLISADIFAGAIFIKLALGLDLYLAI 181
Cdd:cd11492  78 IAYVLVGPITAYIFLPVFYNLQLTSVYEYLELRFN-RRVRLLASFL--FIlQMLLYLPIVIYAPALALSQVTGINLHIII 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 182 FILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEKyvnatpsVVEGDNLTISAscYTPRAD 261
Cdd:cd11492 155 LVVGIVCIFYTTLGGLKAVVWTDVFQVVVMFGGVLAVIILGTIDVGGFSEVWEI-------AEEGGRLEFFN--FDPDPT 225

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 262 SFHIFrdavtgdipWpGIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMisrILYTD 341
Cdd:cd11492 226 VRHTF---------W-SLVIGGTFTWLSLYGVNQTQVQRYLSLPSLKSAKKALWLNIVGLILILSLCCFTGL---VIYAK 292

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 342 MVACvvpsecvkhcgvDVGCTNYA------YPTMVLELMPQ--GLRGLMLS-VMLASLmSSLTSIFNSASTLFTIDLY-T 411
Cdd:cd11492 293 YHDC------------DPLTAGLIkkpdqlLPYFVMDVLGHlpGLPGLFVAgIFSAAL-STLSSGLNSLAAVILEDFIkP 359

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 412 KMRKQASEKELLIAGRIFVLLLTVVSIVWVPLVQVSqnGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMV 491
Cdd:cd11492 360 FFKKKLSERQATNIMKLLVVVFGLLCIGLAFLVEKL--GGVLQLSLSIFGITGGPLLGIFTLGMFFPWANSKGALVGLLV 437

                       490
                ....*....|....*....
gi 14140236 492 GLA-MGLIRMITEFAYGTG 509
Cdd:cd11492 438 GLIfMLWIGIGGQIAIAPG 456
SLC5sbd_u3 cd11479
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
 28-552 3.68e-30

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271373  Cd Length: 454  Bit Score: 123.87  E-value: 3.68e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  28 DISVIVIYFLVVMAVGLWAMLKTNrgTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSV 107
Cdd:cd11479   2 DYGVIALYFAAMIAIGWWGMRRAK--TSEDYLVAGRRLGPGLYLGTMAAVVLGGASTIGGVGLGYQYGISGMWLVVAIGL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 108 MLLILGWIFVPIYIKSGVMTMPEYLKKRFGGeRLQVYLSILSLFICVVLLISADIFAGAIFIKLaLGLDLYLAIFILLAM 187
Cdd:cd11479  80 GILALSLLLAKRIARLKVYTVSEVLELRYGP-SARVISALVMLAYTLMVAVTSTIAIGTVFSVL-FGLPRTLSILVGGGI 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 188 TAVYTTTGGLASVIYTDTLQTIIMLIGSF-ILMGFAFNEVGGYESFTEKyvnatpsvvegdnltISASCYTPradsfhif 266
Cdd:cd11479 158 VVLYSVLGGMWSITLTDIIQFVIKTIGIFlLLLPLALSKAGGLSGLQEK---------------LPASYFDL-------- 214

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 267 rdavtGDIPWPGII-------FGMPItalwywctNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILY 339
Cdd:cd11479 215 -----TSIGWDTIVtyfllyfFGILI--------GQDIWQRVFTARSEKVARWGGVAAGLYCVLYGVAGALIGMAAAVLL 281

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 340 TdmvacvvpsecvkhcgvDVGCTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKM-RKQAS 418
Cdd:cd11479 282 P-----------------DLANPQNAFATMAQEVLPVGLRGLVLAAALAAMMSTASGALLASSTVLTNDVLPRLrRKNES 344

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 419 EKELLIAGRIFVLLLTVVSIVWVPLVQVSQNGQLIHYTESISSYLGPpiaavFVLAIFCKRVNEQGAFWGLMVGLAMGLI 498
Cdd:cd11479 345 ERSEVRLSRLFTLLLGVVVIVIAVLVNDVVAALTIAYAILVGGLLVP-----ILGGLFWKRATGAGALASMVAGSVVVLA 419

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|....
gi 14140236 499 RMITefaYGTgsclaPSNCPkiicgvhyLYFSIVLffgSMLVTLGISLLTKPIP 552
Cdd:cd11479 420 GMAV---DGL-----LANTP--------IYYGLAV---SLVAFVAVSLLTRPTP 454
SLC5sbd_SMCT2 cd11520
Na(+)/monocarboxylate cotransporter SMCT2 and related proteins; solute-binding domain; SMCT2 ...
 26-548 8.70e-25

Na(+)/monocarboxylate cotransporter SMCT2 and related proteins; solute-binding domain; SMCT2 is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. Human SMCT2 (hSMCT2) is encoded by the SLC5A12 gene. SMCT2 is expressed in the kidney, small intestine, skeletal muscle, and retina. In the kidney, it is expressed in the apical membrane of the proximal convoluted tubule, along the entire length of the tubule (in contrast to the high-affinity monocarboxylate transporter SMCT1, belonging to a different family, which is limited to the S3 segment of the tubule). SMCT2 may initiate lactate absorption in the early parts of the tubule. In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner, SMCT2 is expressed exclusively in Muller cells. Nicotine transport by hSMCT2 is inhibited by several non-steroidal anti-inflammatory drugs. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212089 [Multi-domain]  Cd Length: 529  Bit Score: 108.78  E-value: 8.70e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  26 AADISVIVIYFLVVMAVGLWAMLKT-NRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWT 104
Cdd:cd11520   6 AWDYVVFAGLFLVSSGIGVFFAIKErKKATSKEFLVGGRQMSCGPVALSLTASFMSAVTVLGTPAEVYRFGASFVLFFIA 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 105 SSVMLLILGWIFVPIYIKSGVMTMPEYLKKRFggERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFIL 184
Cdd:cd11520  86 YTFVIIFTSELFLPVFYRSGITSTYEYLELRF--NKPVRYAATLIYIVQTILYTGVVVYAPALALNQVTGFDLWGSVFAT 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 185 LAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEKYVNatpsvveGDNLTISASCYTP-RADSF 263
Cdd:cd11520 164 GIVCTFYCTLGGLKAVVWTDAFQMVVMVVGFLTVLIQGSIHNGGFTNVWETAYN-------GSRLNIFDFDVDPlRRHTF 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 264 HIFrdAVTGDIPWPGIifgmpitalwyWCTNQVIVQRCLCGKDMSHVKAACimcaYLKLLPMFLMVMPGMIS-RILYTDM 342
Cdd:cd11520 237 WTI--TVGGTFTWLGI-----------YGVNQSTIQRCISCKTEKHAKLAL----YLNLLGLWIILVCAVFSgLIMYSHY 299

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 343 VACVVPSECVkhcgvdVGCTNYAYPTMVLEL---MPqGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASE 419
Cdd:cd11520 300 KDCDPWTSGF------ISAPDQLMPYFVMEIfstMP-GLPGLFVACAFSGTLSTVAASINALATVTFEDFVKSCFPHLSE 372

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 420 KELLIAGRIFVLLLTVVSIVWVplVQVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIR 499
Cdd:cd11520 373 KLSTWISKGLCILFGVMCTSMA--VAASLMGGVVQAALSIHGMCGGPMLGLFTLGIVFPFVNWKGALGGLLTGITLSFWV 450

                       490       500       510       520       530       540       550
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 14140236 500 MITEFAY------------GTGSC-------LAPSNCPKIIC----------GVHYLYFSIVLFFGSMLVTLGISLLT 548
Cdd:cd11520 451 GIGAFIYpapssktlplelSTAGCilanstaTPTPATPILTSdrplladtwySLSYLYYSAVGCLGCIAAGLLISFLT 528
SLC5sbd_PanF cd10327
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute ...
 29-552 1.31e-24

Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; PanF catalyzes the Na+-coupled uptake of extracellular pantothenate for coenzyme A biosynthesis in cells. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 212037  Cd Length: 472  Bit Score: 107.68  E-value: 1.31e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  29 ISVIVIYFLVVMAVGLWAML---KTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTS 105
Cdd:cd10327   2 LLPIIIYLVILLGIGFYARRskkRRSGDFLEEYFIGGRSMGGFVLAMTLVATYTSASSFIGGPGAAYKIGLGWVLLAMIQ 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 106 SVM----LLILGWIFVPIYIKSGVMTMPEYLKKRFGGERLqVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAI 181
Cdd:cd10327  82 VPTgfltLGVLGKKFAIIARKINAVTIIDYLRARYNSKAL-VVLSSLALIVFFIAAMVAQFIGGARLLEAVTGLSYVTGL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 182 FILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEKYVNATPSVVE---GDNLTIsascytP 258
Cdd:cd10327 161 LIFGLTVILYTTIGGFRAVALTDAIQGIVMIIGTVLLLVGVLAAGGGMEAIMATLAEIDPNLLTpfgPGFLSP------P 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 259 RADSFHIFrdavtgdipwPGI-IFGMPITAlwywctnqvivQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRI 337
Cdd:cd10327 235 YILSFWVL----------VGFgVIGLPQTA-----------VRCMGYKDSKSMHRAMIIGTVVVGFLMLGMHLAGVLGRA 293

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 338 LYTDMvacvvpsecvkhcgvDVGctNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLY---TKMR 414
Cdd:cd10327 294 VLPDL---------------EVP--DKVIPTLALKVLPPWLAGLFLAGPLAAIMSTVDSQLILASSAIVKDLYlnyKNKE 356

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 415 KQASEKEL----LIAGRIFVLLLTVVS------IVWVPLVQVsqnGQLihytesISSYLGPpiaavFVLAIFCKRVNEQG 484
Cdd:cd10327 357 KKTSEKKVkrisLIITIILGLLVFLLAinppdlIVWLNLFAF---GGL------EAAFFWP-----LVLGLYWKRANATG 422

                       490       500       510       520       530       540
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 14140236 485 AFWGLMVGLamglirmitefaygtGSCLAPSNCPKIICGVHYLYFSIVLffgSMLVTLGISLLTKPIP 552
Cdd:cd10327 423 ALASMVVGL---------------VSYILITYLKIKILGLHPIVPSLLL---SLIAFIIVSLATKKPD 472
SLC5sbd_DUR3 cd11476
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is ...
 36-498 2.54e-24

Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is the yeast plasma membrane urea transporter. Saccharomyces cerevisiae DUR3 also transports polyamine. The polyamine uptake of S. cerevisiae DUR3 is activated upon its phosphorylation by polyamine transport protein kinase 2 (PTK2). S. cerevisiae DUR3 also appears to play a role in regulating the cellular boron concentration. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271370  Cd Length: 493  Bit Score: 106.90  E-value: 2.54e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  36 FLVVMAVGLWAMLKTNRGTIG--GFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVT-FEWTSSVMLLIl 112
Cdd:cd11476  11 FALLMVFITRLLKRYRGKNQSseEFMTAGRSVGTGLTAAAIVSSWTWAATLLQSATVAYQYGVSGPFwYASGATLQILL- 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 113 gwiFVPIYIKS-----GVMTMPEYLKKRFGGERLQVYLsILSLFiCVVLLISADIFAGAIFIKLALGLDLYLAIFILLAM 187
Cdd:cd11476  90 ---FAPLAIRIkrlapNAHTLLEIVRARYGTAAHLVFL-VFALF-TNVIVLAMLLLGGSAVVNALTGMPIVAASFLIPLG 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 188 TAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAF--NEVGGYESFTEKYVNATPSVVEGDNltisascytprADSFHI 265
Cdd:cd11476 165 VLLYTLFGGLRATFLTDYIHTVIILIILLVFAFAVYtsSDIGSPSKVYDLLQEAAPDLPVEGN-----------QGSYLT 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 266 FRDavtgdipWPGIIFGMP--ITALWYWCTNQVIVQRCLCGKDMSHVKAACI--MCAYlkLLPMFLMVMPGMISRILYTD 341
Cdd:cd11476 234 FKS-------KAGLIFGIIniVGNFGTVFLDQGYWQRAIAARPSAAVKGYFLggLAWF--AIPFLLATTLGLAALALGLN 304

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 342 mvacvvpsecVKHCGVDVGctnYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLY-TKMRKQASEK 420
Cdd:cd11476 305 ----------PTFEEVSAG---LVLPYVAAALLGKGGAAAVLVLLFMAVTSTASAELIAVSSIVTYDIYrTYINPNATGK 371

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 421 ELLIAGRIFVLLLTVVSIVW-VPLVQVSQN-GQLIHYTESISSylgppiAAVF--VLAIFCKRVNEQGAFWGLMVGLAMG 496
Cdd:cd11476 372 QLLRVSRIAVIGFGLFMGGLaVGLNYIGISlGWLLLFMGILIG------SAVFpvALGLYWRRQTGTAAVVSPIAGLVAG 445


                ..
gi 14140236 497 LI 498
Cdd:cd11476 446 LA 447
SLC5sbd_SMVT cd11504
Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain; This ...
 27-552 4.08e-23

Na(+)/multivitamin cotransporter SMVT and related proteins; solute-binding domain; This multivitamin transporter SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate, and is essential for mediating biotin uptake into mammalian cells. SMVT is expressed in the placenta, intestine, heart, brain, lung, liver, kidney and pancreas. Biotin may regulate its own cellular uptake through participation in holocarboxylase synthetase-dependent chromatin remodeling events at SMVT promoter loci. The cis regulatory elements, Kruppel-like factor 4 and activator protein-2, regulate the activity of the human SMVT promoter in the intestine. Glycosylation of the hSMVT is important for its transport function. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271394 [Multi-domain]  Cd Length: 527  Bit Score: 103.42  E-value: 4.08e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  27 ADISVIVIYFLVVMAVGLW-AMLKTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTS 105
Cdd:cd11504   4 ADYVVFSLLLVISAGIGLYyACTGGKQKTTREFLMADRKMGCLPVALSLLATFQSAVAILGGPSESYTFGTQYWFLGCSY 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 106 SVMLLILGWIFVPIYIKSGVMTMPEYLKKRFggERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILL 185
Cdd:cd11504  84 FLGLLIPAHVFIPVFYRLELTSAYEYLELRF--NKTVRICGTVTFIFQMVIYMGVVLYAPALALNAVTGFNLWISVLAMG 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 186 AMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEKYVNATpsvvegdnltisascytpRADSFHI 265
Cdd:cd11504 162 VVCTFYTALGGLKAVIWTDVFQTVVMFAGQLAVIIVGSIEAGGIARVWRVAAESD------------------RIDGFNL 223

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 266 FRDAVTGDIPWPgIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYtdmvac 345
Cdd:cd11504 224 SPDPTIRHTFWT-LVVGGVFNMLALYGVNQAQVQRYLSSRTEKQAKRSCYLVFPGQQLSLCIGCLCGLVMFARY------ 296

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 346 vvpSECVKHCGVDVGCTNYAYPTMVLELMPQ--GLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELL 423
Cdd:cd11504 297 ---HECDPLKNGIVARSDQLVPYFVMDVLDGlpGLPGLFIACLFSGALSTISSAFNSLATVTMEDLIVPKFPDMTEERAT 373

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 424 IAGRIFVLLLTVVSIVWVPLvqVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGlirmite 503
Cdd:cd11504 374 LLSKGLAVGYGLLCLLMAYL--ASTMGQVLQAANSIFGMIGGPLLGLFCLGMFFPCANSAGAVVGLLAGLFMA------- 444

                       490       500       510       520
                ....*....|....*....|....*....|....*....|....*....
gi 14140236 504 FAYGTGSCLAPSNCPKIICGVHYLYFSIVLFFGSMLVTLGISLLTKPIP 552
Cdd:cd11504 445 FWIGIGSKVFPPYSPTKSTPINDCIFPNVTMANATTPTTPFATPTDEPP 493
SLC5sbd_SMCT cd11505
Na(+)/monocarboxylate cotransporters SMCT1 and 2 and related proteins; solute-binding domain; ...
 28-506 8.97e-23

Na(+)/monocarboxylate cotransporters SMCT1 and 2 and related proteins; solute-binding domain; SMCT1 is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. Human SMCT1 (hSMCT1, also called AIT) is encoded by the tumor suppressor gene SLC5A8. SMCT1 is expressed in the colon, small intestine, kidney, thyroid gland, retina, and brain. SMCT1 may contribute to the intestinal/colonic and oral absorption of monocarboxylate drugs. It also mediates iodide transport from thyrocyte into the colloid lumen in thyroid gland and, through transporting L-lactate and ketone bodies, helps maintain the energy status and the function of neurons. SMCT2 is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. hSMCT2 is encoded by the SLC5A12 gene. SMCT2 is expressed in the kidney, small intestine, skeletal muscle, and retina. In the kidney, SMCT2 may initiate lactate absorption in the early parts of the tubule, SMCT1 in the latter parts of the tubule. In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271395  Cd Length: 538  Bit Score: 102.66  E-value: 8.97e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  28 DISVIVIYFLVVMAVGLW-AMLKTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSS 106
Cdd:cd11505   8 DYVVFAAMLFISAGIGIYyAFAGGGQATSKDFLMGGRQMTAVPVALSLTASFMSAVTVLGTPSEVYRFGASFLIFAFAYL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 107 VMLLILGWIFVPIYIKSGVMTMPEYLKKRFggERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLA 186
Cdd:cd11505  88 FVVLISSEVFLPVFYRLGITSTYEYLELRF--NKPVRLAGTVLFIVQTILYTGIVIYAPALALNQVTGFDLWGAVVATGV 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 187 MTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEKYVNatpsvveGDNLTISAscYTPRADSFHIF 266
Cdd:cd11505 166 VCTFYCTLGGLKAVVWTDVFQVGIMVAGFLSVIIQAVVHQGGIHNILNDSYN-------GSRLNFWD--FDPNPLRRHTF 236

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 267 rdavtgdipWPgIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKaaciMCAYLKLLPMFLM----VMPGMISRILYTDm 342
Cdd:cd11505 237 ---------WT-ITVGGTFTWTGIYGVNQSQVQRYISCKTRFQAK----LSLYFNLLGLWAIlvcaVFSGLAMYSHYKD- 301

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 343 vacvvpseCVKHCGVDVGCTNYAYPTMVLELMPQ--GLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEK 420
Cdd:cd11505 302 --------CDPWTAKIVSAPDQLMPYLVLDILADypGLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFRSLSEK 373

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 421 ELLIAGRIFVLLLTVVSIVWVPLVQVSqnGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRM 500
Cdd:cd11505 374 LSSWISKGLSLLYGAMCIGMAVAASLM--GGLLQAALSIFGMVGGPLLGLFSLGILFPFVNSKGALGGLLTGFAISLWVG 451


                ....*.
gi 14140236 501 ITEFAY 506
Cdd:cd11505 452 IGAQIY 457
SLC5sbd_SMCT1 cd11519
Na(+)/monocarboxylate cotransporter SMCT1 and related proteins; solute-binding domain; SMCT1 ...
 28-497 1.20e-20

Na(+)/monocarboxylate cotransporter SMCT1 and related proteins; solute-binding domain; SMCT1 is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. Human SMCT1 (hSMCT1, also called AIT) is encoded by the tumor suppressor gene SLC5A8. Its expression is under the control of the C/EBP transcription factor. Its tumor-suppressive role is related to uptake of butyrate, propionate, and pyruvate, these latter are inhibitors of histone deacetylases. SMCT1 is expressed in the colon, small intestine, kidney, thyroid gland, retina, and brain. SMCT1 may contribute to the intestinal/colonic and oral absorption of monocarboxylate drugs. SMCT1 also mediates iodide transport from thyrocyte into the colloid lumen in thyroid gland and through transporting l-lactate and ketone bodies helps maintain the energy status and the function of neurons. In the kidney its expression is limited to the S3 segment of the proximal convoluted tubule (in contrast to the low-affinity monocarboxylate transporter SMCT2, belonging to a different family, which is expressed along the entire length of the tubule). In the retina, SMCT1 and SMCT2 may play a differential role in monocarboxylate transport in a cell type-specific manner, SMCT1 is expressed predominantly in retinal neurons and in retinal pigmented epithelial (RPE) cells. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271402  Cd Length: 542  Bit Score: 96.07  E-value: 1.20e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  28 DISVIVIYFLVVMAVGLW-AMLKTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSS 106
Cdd:cd11519   8 DYVVFAGMLLISAGIGIYyAFAGGGQQTSKDFLMGGRQMTAVPVALSLTASFMSAVTVLGTPAEVYRFGAIFSIFAFTYA 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 107 VMLLILGWIFVPIYIKSGVMTMPEYLKKRFGGerlQVYLSILSLFIC-VVLLISADIFAGAIFIKLALGLDLYLAIFILL 185
Cdd:cd11519  88 IVVVISAEVFLPVFYRLGITSTYEYLELRFNK---CVRLIGTSLFIVqTALYTGIVIYAPALALNQVTGFDLWGAVVATG 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 186 AMTAVYTTTGGLASVIYTDTLQTIIMligsfilmgfafneVGGYESftekyVNATPSVVEGDNLTI-SASCYTPRADSFH 264
Cdd:cd11519 165 VVCTFYCTLGGLKAVIWTDVFQVGIM--------------VAGFVS-----VIIRAVVLQGGIGTIlNDSYYGGRLNFWD 225

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 265 IFRDAVTGDIPWPgIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKaaciMCAYLKLLPMFLMVMPGMISRI-LYTdmv 343
Cdd:cd11519 226 FDPNPLQRHTFWT-IVIGGTFTWTSIYGVNQSQVQRYISCKTRFQAK----MSLYVNLVGLWAILSCAVLSGLaMYS--- 297

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 344 acvVPSECVKHCGVDVGCTNYAYPTMVLELMPQ--GLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKE 421
Cdd:cd11519 298 ---IYKDCDPWTAKDVSAPDQLMPYLVLDILADypGLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFRSLSERQ 374

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 14140236 422 LLIAGRIFVLLLTVVSIVWVPLvqVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGL 497
Cdd:cd11519 375 LSWISMGMSVFYGALCIGMAGL--ASLMGALLQAALSIFGMVGGPLLGLFALGILFPFANSIGALVGLMSGFAISL 448
SLC5sbd_NIS cd11503
Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of ...
 28-497 7.14e-19

Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. NIS is expressed in the thyroid, colon, ovary, and in human breast cancers. It mediates the active transport and the concentration of iodide from the blood into thyroid follicular cells, a fundamental step in thyroid hormone biosynthesis, and is the basis of radioiodine therapy for thyroid cancer. Mutation in the SLC5A5 gene can result in a form of thyroid hormone dysgenesis. Human NIS exists mainly as a dimer stabilized by a disulfide bridge. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271393  Cd Length: 535  Bit Score: 90.29  E-value: 7.14e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  28 DISVIVIYFLVVMAVGLWAMLKT-NRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSS 106
Cdd:cd11503   2 DYGVFAAMLLVSTGIGLFVGLARgGQRSADDFFTGGRGLSAVPVGLSLSASFMSAVQVLGVPSEAYRYGLKFLWMCLGQL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 107 VMLLILGWIFVPIYIKSGVMTMPEYLKKRFGgeRLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLA 186
Cdd:cd11503  82 LNSLMTAVLFMPVFYRLGITSTYQYLEMRFS--RAVRLCGTLQFIVATMLYTGIVIYAPALILNQVTGLDIWASLFSTGI 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 187 MTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEkyvnatpsvVEGDNLTISASCYTPRADSFHIF 266
Cdd:cd11503 160 ICTFYTTVGGMKAVIWTDVFQVVVMLSGFWAVLIRGVILVGGPRRVLE---------IAQNHSRINFMDFDPDPRRRYTF 230

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 267 rdavtgdipWPGIIFGmpiTALW--YWCTNQVIVQRCLCGKDMSHVKAACImcayLKLLPMFLMVMPGMISRIlytdmVA 344
Cdd:cd11503 231 ---------WTFVVGG---TLVWlsMYGVNQAQVQRYVACRTEKQAKLALL----VNQVGLCLIVSSAATCGI-----VM 289

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 345 CVVPSECVKHCGVDVGCTNYAYPTMVLELMPQ--GLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKEL 422
Cdd:cd11503 290 FVYYSNCDPLLIGRISAPDQYMPYLVLDIFEDlpGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRLPTIAPRKL 369

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 14140236 423 LIAGRIFVLLLTVVSIVWVPLVQVSQNGQLiHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGL 497
Cdd:cd11503 370 VFISKGLSLIYGSACITVAALSSLLGGGVL-QGSFTVMGVISGPLLGAFALGMFLPACNTPGVFSGLAVGLALSL 443
SLC5sbd_u4 cd11480
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ...
 33-494 4.32e-16

Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.


Pssm-ID: 271374  Cd Length: 488  Bit Score: 81.40  E-value: 4.32e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  33 VIYFLVVMAVGL---WAMLKTNRGTiGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFE--WTSSV 107
Cdd:cd11480   1 IGLFFVFVTITLyitIWAARRTRST-SDFYVAGRGVPPVQNGLAIAGDYMSAASFLGIAGLIALSGYDGLAYAigWTGGY 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 108 MLLILgwIFVPIYIKSGVMTMPEYLKKRFGGERLQVYLSILSLFICVVLLIsADIFAGAIFIKLALGLDLYLAIFILLAM 187
Cdd:cd11480  80 VLLLL--LVAEPLRNFGKYTVPDFLGARLGSRPVRLVAAVSTLVISFFYLV-AQMVGAGLLLSLLLGIPYEVGVVVVGAL 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 188 TAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYesftekyvnatPSVVEGDNLTISASCYTPRADSFHIFR 267
Cdd:cd11480 157 MIVYVVLGGMRATTWVQIIQYVLLLGAFLVPAILVLARFGGN-----------PLGAGPGLLGLAAAAASGAGEAYLAPG 225

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 268 DAVTGDIPWPGIIFGMPI-TAlwywCTNQVIVqRCLCGKDM-----SHVKAACIMCAYLkllpmFLMVMPGMISRIL-YT 340
Cdd:cd11480 226 LLLTDPLDVISLTLALMLgTA----GLPHVLM-RFYTVPDAraarkSVVWALGFIGLFY-----LLAPALGFGARALvGP 295

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236 341 DMVACVVPSECVKHcgvdvgcTNYAYPTMVLEL-MPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKM-RKQAS 418
Cdd:cd11480 296 DVIGAPIAGELDGG-------GDMAVLLLPEIAgLGDLLLALVAAGAFAAILATVAGLLLAAASALAHDLYAGViRPGAS 368

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 14140236 419 EKELLIAGRIFVLLLTVVSIvWVPLVQVSQN-GQLIHYTESI--SSylgppIAAVFVLAIFCKRVNEQGAFWGLMVGLA 494
Cdd:cd11480 369 ERREVRVARIAAVVVGVIAI-LLALLFPPQNvAFLVALAFAIaaSA-----FFPVLVLGIFWRRFTTRGAIAGMLVGLL 441
PRK15419 PRK15419
sodium/proline symporter PutP;
33-508 3.96e-11

sodium/proline symporter PutP;


Pssm-ID: 185317  Cd Length: 502  Bit Score: 65.81  E-value: 3.96e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236   33 VIYFLVVMAVGLWAMLKTNrgTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVAT--VTFEWTSSVML- 109
Cdd:PRK15419  12 CVYIFGMILIGFIAWRSTK--NFDDYILGGRSLGPFVTALSAGASDMSGWLLMGLPGAVFLSGISEswIAIGLTLGAWIn 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  110 --LILGWIFVPIYIKSGVMTMPEYLKKRF-GGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLA 186
Cdd:PRK15419  90 wkLVAGRLRVHTEYNNNALTLPDYFTGRFeDKSRILRIISALVILLFFTIYCASGIVAGARLFESTFGMSYETALWAGAA 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  187 MTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGY----ESFTEKYVNATpSVVEGDNLTisascytprads 262
Cdd:PRK15419 170 ATILYTFIGGFLAVSWTDTVQASLMIFALILTPVIVIISVGGFgdslEVIKQKSIENV-DMLKGLNFV------------ 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  263 fhifrdAVTGDIPWPGIIFGMPitalwywctnqVIVQRCLCGKDMSHVKAAcimcaylkllpmflmvmpgmiSRILYTDM 342
Cdd:PRK15419 237 ------AIISLMGWGLGYFGQP-----------HILARFMAADSHHSIVHA---------------------RRISMTWM 278

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  343 VACVVPSECVKHCGV--------DVGCTNYAYPTMVLEL----MPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLY 410
Cdd:PRK15419 279 ILCLAGAVAVGFFGIayfnehpaVAGAVNQNAERVFIELaqilFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLY 358

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236  411 TK-MRKQASEKELLIAGRIFVLlltVVSIVWVPLVQVSQNGQLIHYTESISSYlGPPIAAVFVLAIFCKRVNEQGAFWGL 489
Cdd:PRK15419 359 KAfLRKHASQKELVWVGRVMVL---VVALVAIALAANPENRVLGLVSYAWAGF-GAAFGPVVLFSVMWSRMTRNGALAGM 434

                        490       500
                 ....*....|....*....|....*....
gi 14140236  490 MVGLA----------MGLIRMITEFAYGT 508
Cdd:PRK15419 435 IIGALtvivwkqfgwLGLYEIIPGFIFGS 463
PRK12488 PRK12488
cation/acetate symporter;
1-227 1.34e-03

cation/acetate symporter;


Pssm-ID: 237114 [Multi-domain]  Cd Length: 549  Bit Score: 41.71  E-value: 1.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236    1 MASTVSPSTIAETPEPPplsdhiRNAADISVIVIYFLVVMAVGLWAMLKTNRGTigGFFLAGRDMAWWPMGASLFASNIG 80
Cdd:PRK12488  13 SGALLASPALDAGQRQP------LNWTAIGMFMVFVLFTLGITRWAARRTRSAS--DFYTAGGGLTGMQNGLAIAGDMIS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14140236   81 SNHYVGLAGTGAASGVATVTFewtssVMLLILGWIFVPIYIKS-----GVMTMPEYLKKRFGGERLQVYLSILSLFICVV 155
Cdd:PRK12488  85 AASFLGISAMMFMNGYDGLLY-----ALGVLAGWPIILFLIAErlrnlGKYTFADVVSYRLAQGPVRLTAAFGTLTVVLM 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 14140236  156 LLISADIFAGAIfIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVG 227
Cdd:PRK12488 160 YLVAQMVGAGKL-IELLFGISYLYAVVIVGALMVLYVTFGGMLATTWVQIIKAVLLLSGTSFMAFMVLKHFG 230
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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