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Conserved domains on  [gi|7656991|ref|NP_055140|]
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coronin-1C isoform b [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-402 3.05e-111

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 337.64  E-value: 3.05e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991     8 SKFRHVFGQAVKNDQCYDDIRVSRVTWD-SSFCAVNPRFVAIIIEASGGGAflVLPLHKTGRIDKSYPTVCGHTGPVLDI 86
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991    87 DWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLTEPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEAl 166
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKA- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991   167 INLDDMHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEkAHEGARPMRAIFLADGN-VFTTGFSRMSERQL 245
Cdd:PTZ00421 161 VEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQRQI 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991   246 ALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESPYVHYlnTFSSKEPQRGMGYMPKRGL 325
Cdd:PTZ00421 240 MLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSL 317

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 7656991   326 DVNKCEIARFFKLHERKCEPIIMTVPRK-SDL-FQDDLYPDTAGPEAALEAEEWFEGKNADPILISLkHGYIPGKNRDL 402
Cdd:PTZ00421 318 DTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDM-SAVFDGTSPEL 395
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 8-402 3.05e-111

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 337.64  E-value: 3.05e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991     8 SKFRHVFGQAVKNDQCYDDIRVSRVTWD-SSFCAVNPRFVAIIIEASGGGAflVLPLHKTGRIDKSYPTVCGHTGPVLDI 86
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991    87 DWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLTEPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEAl 166
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKA- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991   167 INLDDMHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEkAHEGARPMRAIFLADGN-VFTTGFSRMSERQL 245
Cdd:PTZ00421 161 VEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQRQI 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991   246 ALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESPYVHYlnTFSSKEPQRGMGYMPKRGL 325
Cdd:PTZ00421 240 MLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSL 317

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 7656991   326 DVNKCEIARFFKLHERKCEPIIMTVPRK-SDL-FQDDLYPDTAGPEAALEAEEWFEGKNADPILISLkHGYIPGKNRDL 402
Cdd:PTZ00421 318 DTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDM-SAVFDGTSPEL 395
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 3-68 2.18e-36

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 128.39  E-value: 2.18e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7656991      3 RVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPRFVAIIIEASGGGAFLVLPLHKTGR 68
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 75-300 1.88e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.97  E-value: 1.88e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991   75 TVCGHTGPVLDIDWCPHNDQvIASGSEDCTVMVWQipengltLSLTEPVVILEGHSKRVGIVAWHPTARnVLLSAGCDNA 154
Cdd:cd00200  46 TLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWD-------LETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKT 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991  155 IIIWNVGTGEALINLDDmHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEkAHEGarPMRAI-FLADGNVF 233
Cdd:cd00200 117 IKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLT-GHTG--EVNSVaFSPDGEKL 192

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991  234 TTGFsrmSERQLALWNPKnMQEPIAL---HEmDTSNGVLlpfYDPDTSIIyLCGKGDSSIRYFEITDESP 300
Cdd:cd00200 193 LSSS---SDGTIKLWDLS-TGKCLGTlrgHE-NGVNSVA---FSPDGYLL-ASGSEDGTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
78-252 1.76e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 1.76e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991   78 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQIPENgltlsltEPVVILEGHSKRVGIVAWHPTARnVLLSAGCDNAIII 157
Cdd:COG2319 160 GHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATG-------KLLRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRL 230

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991  158 WNVGTGEALINLDDmHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEkaHEGARPMRAIFLADGNVFTTGf 237
Cdd:COG2319 231 WDLATGKLLRTLTG-HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSPDGKLLASG- 306

                       170
                ....*....|....*
gi 7656991  238 srMSERQLALWNPKN 252
Cdd:COG2319 307 --SDDGTVRLWDLAT 319
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 78-108 9.48e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 9.48e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 7656991      78 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVW 108
Cdd:smart00320  10 GHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 8-402 3.05e-111

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 337.64  E-value: 3.05e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991     8 SKFRHVFGQAVKNDQCYDDIRVSRVTWD-SSFCAVNPRFVAIIIEASGGGAflVLPLHKTGRIDKSYPTVCGHTGPVLDI 86
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991    87 DWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLTEPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEAl 166
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKA- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991   167 INLDDMHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEkAHEGARPMRAIFLADGN-VFTTGFSRMSERQL 245
Cdd:PTZ00421 161 VEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQRQI 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991   246 ALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESPYVHYlnTFSSKEPQRGMGYMPKRGL 325
Cdd:PTZ00421 240 MLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSL 317

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 7656991   326 DVNKCEIARFFKLHERKCEPIIMTVPRK-SDL-FQDDLYPDTAGPEAALEAEEWFEGKNADPILISLkHGYIPGKNRDL 402
Cdd:PTZ00421 318 DTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDM-SAVFDGTSPEL 395
PTZ00420 PTZ00420
coronin; Provisional
 24-455 9.07e-67

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 224.06  E-value: 9.07e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991    24 YDDIRV-SRVTwDSSFCAVNPRFVAIIIEASGGGAFLVLPLHKTGRidksYPTVC---GHTGPVLDIDWCPHNDQVIASG 99
Cdd:PTZ00420  19 FDDLRIcSRVI-DSCGIACSSGFVAVPWEVEGGGLIGAIRLENQMR----KPPVIklkGHTSSILDLQFNPCFSEILASG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991   100 SEDCTVMVWQIPENGLTLS-LTEPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEAL--INLDDMHSDM 176
Cdd:PTZ00420  94 SEDLTIRVWEIPHNDESVKeIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAfqINMPKKLSSL 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991   177 iynvSWNRNGSLICTASKDKKVRVIDPRKQEIvAEKEKAHEGARPMRAIFL-----ADGNVFTTGFSRMSERQLALWNPK 251
Cdd:PTZ00420 174 ----KWNIKGNLLSGTCVGKHMHIIDPRKQEI-ASSFHIHDGGKNTKNIWIdglggDDNYILSTGFSKNNMREMKLWDLK 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991   252 NMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESpyVHYLNTFSSKEPQRGMGYMPKRGLDVNKCE 331
Cdd:PTZ00420 249 NTTSALVTMSIDNASAPLIPHYDESTGLIYLIGKGDGNCRYYQHSLGS--IRKVNEYKSCSPFRSFGFLPKQICDVYKCE 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991   332 IARFFK-LHERKCEPIIMTVPRK-SDLFQDDLYPDTAGPEAALEAEEWFEGKNADPILISLKHgyipGKNRDLKVVKK-- 407
Cdd:PTZ00420 327 IGRVYKnENNSSIRPISFYVPRKnPTKFQEDLYPPILMHDPERSSRNWIDGKDNKMKRINIKD----LTEDDLRITKKyk 402

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 7656991   408 -------NILDSKPTANKKCdliSIPKKTTDTASVQNEAKLDEILKEIKSIKDTI 455
Cdd:PTZ00420 403 fvpqsfnSIIIGENYTSKRT---SIIRQFTKKFTFFKKGEHNDGFSSVDSFKESV 454
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 3-68 2.18e-36

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 128.39  E-value: 2.18e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7656991      3 RVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPRFVAIIIEASGGGAFLVLPLHKTGR 68
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 75-300 1.88e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.97  E-value: 1.88e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991   75 TVCGHTGPVLDIDWCPHNDQvIASGSEDCTVMVWQipengltLSLTEPVVILEGHSKRVGIVAWHPTARnVLLSAGCDNA 154
Cdd:cd00200  46 TLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWD-------LETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKT 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991  155 IIIWNVGTGEALINLDDmHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEkAHEGarPMRAI-FLADGNVF 233
Cdd:cd00200 117 IKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLT-GHTG--EVNSVaFSPDGEKL 192

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991  234 TTGFsrmSERQLALWNPKnMQEPIAL---HEmDTSNGVLlpfYDPDTSIIyLCGKGDSSIRYFEITDESP 300
Cdd:cd00200 193 LSSS---SDGTIKLWDLS-TGKCLGTlrgHE-NGVNSVA---FSPDGYLL-ASGSEDGTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
78-252 1.76e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 1.76e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991   78 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQIPENgltlsltEPVVILEGHSKRVGIVAWHPTARnVLLSAGCDNAIII 157
Cdd:COG2319 160 GHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATG-------KLLRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRL 230

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991  158 WNVGTGEALINLDDmHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEkaHEGARPMRAIFLADGNVFTTGf 237
Cdd:COG2319 231 WDLATGKLLRTLTG-HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSPDGKLLASG- 306

                       170
                ....*....|....*
gi 7656991  238 srMSERQLALWNPKN 252
Cdd:COG2319 307 --SDDGTVRLWDLAT 319
WD40 COG2319
WD40 repeat [General function prediction only];
78-251 1.38e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.30  E-value: 1.38e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991   78 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQIpENGltlsltEPVVILEGHSKRVGIVAWHPTARnVLLSAGCDNAIII 157
Cdd:COG2319 118 GHTGAVRSVAFSP-DGKTLASGSADGTVRLWDL-ATG------KLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRL 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991  158 WNVGTGEALINLDDmHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEkaHEGARPMRAIFLADGNVFTTGf 237
Cdd:COG2319 189 WDLATGKLLRTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT--GHSGSVRSVAFSPDGRLLASG- 264

                       170
                ....*....|....
gi 7656991  238 srMSERQLALWNPK 251
Cdd:COG2319 265 --SADGTVRLWDLA 276
WD40 COG2319
WD40 repeat [General function prediction only];
78-252 6.83e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.37  E-value: 6.83e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991   78 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQIPENgltlsltEPVVILEGHSKRVGIVAWHPTARnVLLSAGCDNAIII 157
Cdd:COG2319 244 GHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATG-------ELLRTLTGHSGGVNSVAFSPDGK-LLASGSDDGTVRL 314

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991  158 WNVGTGEALINLDDmHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKeKAHEGArPMRAIFLADGNVFTTGf 237
Cdd:COG2319 315 WDLATGKLLRTLTG-HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL-TGHTGA-VTSVAFSPDGRTLASG- 390

                       170
                ....*....|....*
gi 7656991  238 SRmsERQLALWNPKN 252
Cdd:COG2319 391 SA--DGTVRLWDLAT 403
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 343-385 3.60e-21

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 86.03  E-value: 3.60e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 7656991    343 CEPIIMTVPRKS-DLFQDDLYPDTAGPEAALEAEEWFEGKNADP 385
Cdd:pfam16300   1 IEPISFTVPRKSkEDFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 78-236 4.76e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.17  E-value: 4.76e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991   78 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQIPENgltlsltEPVVILEGHSKRVGIVAWHPTARNvLLSAGCDNAIII 157
Cdd:cd00200 133 GHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTG-------KCVATLTGHTGEVNSVAFSPDGEK-LLSSSSDGTIKL 203

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991  158 WNVGTGEALINLDDmHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKeKAHEGarPMRAI-FLADGNVFTTG 236
Cdd:cd00200 204 WDLSTGKCLGTLRG-HENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL-SGHTN--SVTSLaWSPDGKRLASG 279
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 78-200 7.25e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.92  E-value: 7.25e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991   78 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQipengltLSLTEPVVILEGHSKRVGIVAWHPTaRNVLLSAGCDNAIII 157
Cdd:cd00200 175 GHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWD-------LSTGKCLGTLRGHENGVNSVAFSPD-GYLLASGSEDGTIRV 245

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 7656991  158 WNVGTGEALINLDdMHSDMIYNVSWNRNGSLICTASKDKKVRV 200
Cdd:cd00200 246 WDLRTGECVQTLS-GHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 126-300 8.84e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.52  E-value: 8.84e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991  126 LEGHSKRVGIVAWHPTaRNVLLSAGCDNAIIIWNVGTGEALINLDDmHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRK 205
Cdd:cd00200   5 LKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKG-HTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991  206 QEIVAEKEkAHEGarPMRAI-FLADGNVFTTGfsrMSERQLALWNPKNMQEPIAL--HEMDTSNGVllpfYDPDTSIIYl 282
Cdd:cd00200  83 GECVRTLT-GHTS--YVSSVaFSPDGRILSSS---SRDKTIKVWDVETGKCLTTLrgHTDWVNSVA----FSPDGTFVA- 151

                       170
                ....*....|....*...
gi 7656991  283 CGKGDSSIRYFEITDESP 300
Cdd:cd00200 152 SSSQDGTIKLWDLRTGKC 169
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 78-108 9.48e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 9.48e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 7656991      78 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVW 108
Cdd:smart00320  10 GHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
75-108 5.35e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 5.35e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 7656991     75 TVCGHTGPVLDIDWCPhNDQVIASGSEDCTVMVW 108
Cdd:pfam00400   6 TLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 121-159 1.16e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.16e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 7656991     121 EPVVILEGHSKRVGIVAWHPTaRNVLLSAGCDNAIIIWN 159
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 173-202 2.04e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 2.04e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 7656991     173 HSDMIYNVSWNRNGSLICTASKDKKVRVID 202
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 65-109 3.39e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.32  E-value: 3.39e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 7656991   65 KTGRIDKsypTVCGHTGPVLDIDWCPHNdQVIASGSEDCTVMVWQ 109
Cdd:cd00200 249 RTGECVQ---TLSGHTNSVTSLAWSPDG-KRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
121-159 5.37e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 5.37e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 7656991    121 EPVVILEGHSKRVGIVAWHPTaRNVLLSAGCDNAIIIWN 159
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
173-202 6.48e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 6.48e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 7656991    173 HSDMIYNVSWNRNGSLICTASKDKKVRVID 202
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 88-185 9.77e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.41  E-value: 9.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7656991     88 WCPHNDqVIASGSEDCTV--------MVWQIPengltlsltepvviLEGHSKRVGIVAWHPTARnVLLSAGCDNAIIIWN 159
Cdd:pfam12894   3 WCPTMD-LIALATEDGELllhrlnwqRVWTLS--------------PDKEDLEVTSLAWRPDGK-LLAVGYSDGTVRLLD 66

                          90       100
                  ....*....|....*....|....*.
gi 7656991    160 VGTGEALINLdDMHSDMIYNVSWNRN 185
Cdd:pfam12894  67 AENGKIVHHF-SAGSDLITCLGWGEN 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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