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Conserved domains on  [gi|45827771|ref|NP_055144|]
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enhancer of mRNA-decapping protein 4 isoform 2 [Homo sapiens]

Protein Classification

Ge1_WD40 and PHA03247 domain-containing protein( domain architecture ID 12178812)

Ge1_WD40 and PHA03247 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ge1_WD40 super family cl25640
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of ...
 114-441 0e+00

WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of Ge-1 or enhancer of mRNA-decapping proteins. WD40-repeat regions are involved in protein-protein interactions.


The actual alignment was detected with superfamily member pfam16529:

Pssm-ID: 465162 [Multi-domain]  Cd Length: 328  Bit Score: 546.28  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771    114 GSNKVKIQPVAKYDWEQKYYYGNLIAV--SNSFLAYAIRAaNNGSAMVRVISVSTSERTLLKGFTGSVADLAFAHLNSPQ 191
Cdd:pfam16529    1 GSSKVKLKNIVDYKWERKYYPGQLVAVhrDGKYLAYAIKV-KNGGGMVRVINIETSERALLKGMTGEVLDLAFAHTDCVI 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771    192 LACLDEAGNLFVWRLALVNGKIQEEILVHIRQPEGTPLNHFRRIIWCPFIPEESEDCCEE--SSPTVALLHEDRAEVWDL 269
Cdd:pfam16529   80 LACVDDVGNLFVYKVDQIEGKILCNLLLHIEDPIGTYPSEYHRVIWCPYIPEDDETESDDddESKLLVLLRGDKAEIWNV 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771    270 DMLRSSHSTWPVDVSQIKQGFIVVKGHStCLSEGALSPDGTVLATASHDGYVKFWQIYIEGQDEPRCLHEWKPHDGRPLS 349
Cdd:pfam16529  160 DMIVSEHGSGPLQPAALESGYIEIEEHS-LLVDAAFSPDGTALATASLDGEVKFFQIYLFDNRNPRCLHEWKPHDGKPLS 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771    350 CLLFCDNHKKQdPDVPFWRFLITGADQNRELKMWCTVSWTCLQTIRFSPDIFSSVSvPPSLKVCLDLSAEYLILSDVQRK 429
Cdd:pfam16529  239 SLFFLDNHKKP-PEVQFWRFAITGADNNSELKLWSCESWTCLQTIRFVPDPPSSLQ-PPNLKAGLDLSANYLVLSDLDNK 316

                          330
                   ....*....|..
gi 45827771    430 VLYVMELLQNQE 441
Cdd:pfam16529  317 VLYVLQLGQDGE 328
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 525-982 4.67e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 4.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771   525 PQLNPDVVAPLPTHTAHEDFTFGESRPELGSEGLGSAAHGSQpdlRRIVELPAPADFLSLSSETKPKLMTPDAFMTPSAS 604
Cdd:PHA03247 2713 HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGP---ARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVA 2789

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771   605 LQQITASPSSSSSGSSSSSSSSSSSLTAVSAMSSTSAVDPSLTRPPEELTLSPKLQLDGSLTMSSSgslqASPRGLLPGL 684
Cdd:PHA03247 2790 SLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGS----VAPGGDVRRR 2865

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771   685 LPAPADKLTPKGPGQVPTATSALSLELQEVEPLGLPQASPSRTRSPDvissastalsqdipeiasealsrgfgsSAPEGL 764
Cdd:PHA03247 2866 PPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQ---------------------------APPPPQ 2918

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771   765 EPDSMASAASALHLLSPRPRPGPELGPQLGLDGGPGDGDRHNTPSlLEAALTQEASTPDSQVWPTAPDITRETCST--LA 842
Cdd:PHA03247 2919 PQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPW-LGALVPGRVAVPRFRVPQPAPSREAPASSTppLT 2997

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771   843 ESPRNGLQEKHKSLAFHR----PPYHLLQQRDSQDasaeQSDHDDEVASLASASGGFGTKV-----PAPRLPAKDWKTKG 913
Cdd:PHA03247 2998 GHSLSRVSSWASSLALHEetdpPPVSLKQTLWPPD----DTEDSDADSLFDSDSERSDLEAldplpPEPHDPFAHEPDPA 3073

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45827771   914 SP----RTSPKLKRKSKKDDGDAAMGSRLTEHQVAEPPEDWPALIWQQQRELAELRHSqeeLLQRLCTQLEGL 982
Cdd:PHA03247 3074 TPeagaRESPSSQFGPPPLSANAALSRRYVRSTGRSALAVLIEACRRIRRQLRRTRHA---LLDRSGAVLTGL 3143
 
Name Accession Description Interval E-value
Ge1_WD40 pfam16529
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of ...
 114-441 0e+00

WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of Ge-1 or enhancer of mRNA-decapping proteins. WD40-repeat regions are involved in protein-protein interactions.


Pssm-ID: 465162 [Multi-domain]  Cd Length: 328  Bit Score: 546.28  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771    114 GSNKVKIQPVAKYDWEQKYYYGNLIAV--SNSFLAYAIRAaNNGSAMVRVISVSTSERTLLKGFTGSVADLAFAHLNSPQ 191
Cdd:pfam16529    1 GSSKVKLKNIVDYKWERKYYPGQLVAVhrDGKYLAYAIKV-KNGGGMVRVINIETSERALLKGMTGEVLDLAFAHTDCVI 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771    192 LACLDEAGNLFVWRLALVNGKIQEEILVHIRQPEGTPLNHFRRIIWCPFIPEESEDCCEE--SSPTVALLHEDRAEVWDL 269
Cdd:pfam16529   80 LACVDDVGNLFVYKVDQIEGKILCNLLLHIEDPIGTYPSEYHRVIWCPYIPEDDETESDDddESKLLVLLRGDKAEIWNV 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771    270 DMLRSSHSTWPVDVSQIKQGFIVVKGHStCLSEGALSPDGTVLATASHDGYVKFWQIYIEGQDEPRCLHEWKPHDGRPLS 349
Cdd:pfam16529  160 DMIVSEHGSGPLQPAALESGYIEIEEHS-LLVDAAFSPDGTALATASLDGEVKFFQIYLFDNRNPRCLHEWKPHDGKPLS 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771    350 CLLFCDNHKKQdPDVPFWRFLITGADQNRELKMWCTVSWTCLQTIRFSPDIFSSVSvPPSLKVCLDLSAEYLILSDVQRK 429
Cdd:pfam16529  239 SLFFLDNHKKP-PEVQFWRFAITGADNNSELKLWSCESWTCLQTIRFVPDPPSSLQ-PPNLKAGLDLSANYLVLSDLDNK 316

                          330
                   ....*....|..
gi 45827771    430 VLYVMELLQNQE 441
Cdd:pfam16529  317 VLYVLQLGQDGE 328
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 260-409 2.10e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 57.34  E-value: 2.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771  260 HEDraEVWDLDMLRSSH--ST---------WPVDVSQIKQgfiVVKGHSTCLSEGALSPDGTVLATASHDGYVKFWQIyi 328
Cdd:cd00200   92 HTS--YVSSVAFSPDGRilSSssrdktikvWDVETGKCLT---TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL-- 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771  329 egqDEPRCLHEWKPHDGrPLSCLLFCDNHKKqdpdvpfwrfLITGADqNRELKMWCTVSWTCLQTIRFSPDIFSSVSVPP 408
Cdd:cd00200  165 ---RTGKCVATLTGHTG-EVNSVAFSPDGEK----------LLSSSS-DGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229


                 .
gi 45827771  409 S 409
Cdd:cd00200  230 D 230
WD40 COG2319
WD40 repeat [General function prediction only];
159-399 9.35e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.07  E-value: 9.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771  159 VRVISVSTSERTL-LKGFTGSVADLAFAHlNSPQLACLDEAGNLFVWRLAlvngkiqeeilvhiRQPEGTPLNHFRRIIW 237
Cdd:COG2319  186 VRLWDLATGKLLRtLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLA--------------TGKLLRTLTGHSGSVR 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771  238 CP-FIPEESedcceesspTVALLHEDR-AEVWDLDMLRSSHstwpvdvsqikqgfiVVKGHSTCLSEGALSPDGTVLATA 315
Cdd:COG2319  251 SVaFSPDGR---------LLASGSADGtVRLWDLATGELLR---------------TLTGHSGGVNSVAFSPDGKLLASG 306

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771  316 SHDGYVKFWQIyiegqDEPRCLHEWKPHDGRPLScLLFcdnhkkqDPDVpfwRFLITGADQNReLKMWCTVSWTCLQTIR 395
Cdd:COG2319  307 SDDGTVRLWDL-----ATGKLLRTLTGHTGAVRS-VAF-------SPDG---KTLASGSDDGT-VRLWDLATGELLRTLT 369

                        250
                 ....*....|....
gi 45827771  396 ----------FSPD 399
Cdd:COG2319  370 ghtgavtsvaFSPD 383
PHA03247 PHA03247
large tegument protein UL36; Provisional
 525-982 4.67e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 4.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771   525 PQLNPDVVAPLPTHTAHEDFTFGESRPELGSEGLGSAAHGSQpdlRRIVELPAPADFLSLSSETKPKLMTPDAFMTPSAS 604
Cdd:PHA03247 2713 HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGP---ARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVA 2789

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771   605 LQQITASPSSSSSGSSSSSSSSSSSLTAVSAMSSTSAVDPSLTRPPEELTLSPKLQLDGSLTMSSSgslqASPRGLLPGL 684
Cdd:PHA03247 2790 SLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGS----VAPGGDVRRR 2865

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771   685 LPAPADKLTPKGPGQVPTATSALSLELQEVEPLGLPQASPSRTRSPDvissastalsqdipeiasealsrgfgsSAPEGL 764
Cdd:PHA03247 2866 PPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQ---------------------------APPPPQ 2918

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771   765 EPDSMASAASALHLLSPRPRPGPELGPQLGLDGGPGDGDRHNTPSlLEAALTQEASTPDSQVWPTAPDITRETCST--LA 842
Cdd:PHA03247 2919 PQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPW-LGALVPGRVAVPRFRVPQPAPSREAPASSTppLT 2997

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771   843 ESPRNGLQEKHKSLAFHR----PPYHLLQQRDSQDasaeQSDHDDEVASLASASGGFGTKV-----PAPRLPAKDWKTKG 913
Cdd:PHA03247 2998 GHSLSRVSSWASSLALHEetdpPPVSLKQTLWPPD----DTEDSDADSLFDSDSERSDLEAldplpPEPHDPFAHEPDPA 3073

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45827771   914 SP----RTSPKLKRKSKKDDGDAAMGSRLTEHQVAEPPEDWPALIWQQQRELAELRHSqeeLLQRLCTQLEGL 982
Cdd:PHA03247 3074 TPeagaRESPSSQFGPPPLSANAALSRRYVRSTGRSALAVLIEACRRIRRQLRRTRHA---LLDRSGAVLTGL 3143
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 292-324 4.99e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 4.99e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 45827771     292 VVKGHS---TCLsegALSPDGTVLATASHDGYVKFW 324
Cdd:smart00320    7 TLKGHTgpvTSV---AFSPDGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
Ge1_WD40 pfam16529
WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of ...
 114-441 0e+00

WD40 region of Ge1, enhancer of mRNA-decapping protein; Ge1_WD40 is the N-terminal region of Ge-1 or enhancer of mRNA-decapping proteins. WD40-repeat regions are involved in protein-protein interactions.


Pssm-ID: 465162 [Multi-domain]  Cd Length: 328  Bit Score: 546.28  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771    114 GSNKVKIQPVAKYDWEQKYYYGNLIAV--SNSFLAYAIRAaNNGSAMVRVISVSTSERTLLKGFTGSVADLAFAHLNSPQ 191
Cdd:pfam16529    1 GSSKVKLKNIVDYKWERKYYPGQLVAVhrDGKYLAYAIKV-KNGGGMVRVINIETSERALLKGMTGEVLDLAFAHTDCVI 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771    192 LACLDEAGNLFVWRLALVNGKIQEEILVHIRQPEGTPLNHFRRIIWCPFIPEESEDCCEE--SSPTVALLHEDRAEVWDL 269
Cdd:pfam16529   80 LACVDDVGNLFVYKVDQIEGKILCNLLLHIEDPIGTYPSEYHRVIWCPYIPEDDETESDDddESKLLVLLRGDKAEIWNV 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771    270 DMLRSSHSTWPVDVSQIKQGFIVVKGHStCLSEGALSPDGTVLATASHDGYVKFWQIYIEGQDEPRCLHEWKPHDGRPLS 349
Cdd:pfam16529  160 DMIVSEHGSGPLQPAALESGYIEIEEHS-LLVDAAFSPDGTALATASLDGEVKFFQIYLFDNRNPRCLHEWKPHDGKPLS 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771    350 CLLFCDNHKKQdPDVPFWRFLITGADQNRELKMWCTVSWTCLQTIRFSPDIFSSVSvPPSLKVCLDLSAEYLILSDVQRK 429
Cdd:pfam16529  239 SLFFLDNHKKP-PEVQFWRFAITGADNNSELKLWSCESWTCLQTIRFVPDPPSSLQ-PPNLKAGLDLSANYLVLSDLDNK 316

                          330
                   ....*....|..
gi 45827771    430 VLYVMELLQNQE 441
Cdd:pfam16529  317 VLYVLQLGQDGE 328
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 260-409 2.10e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 57.34  E-value: 2.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771  260 HEDraEVWDLDMLRSSH--ST---------WPVDVSQIKQgfiVVKGHSTCLSEGALSPDGTVLATASHDGYVKFWQIyi 328
Cdd:cd00200   92 HTS--YVSSVAFSPDGRilSSssrdktikvWDVETGKCLT---TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL-- 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771  329 egqDEPRCLHEWKPHDGrPLSCLLFCDNHKKqdpdvpfwrfLITGADqNRELKMWCTVSWTCLQTIRFSPDIFSSVSVPP 408
Cdd:cd00200  165 ---RTGKCVATLTGHTG-EVNSVAFSPDGEK----------LLSSSS-DGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229


                 .
gi 45827771  409 S 409
Cdd:cd00200  230 D 230
WD40 COG2319
WD40 repeat [General function prediction only];
159-399 9.35e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.07  E-value: 9.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771  159 VRVISVSTSERTL-LKGFTGSVADLAFAHlNSPQLACLDEAGNLFVWRLAlvngkiqeeilvhiRQPEGTPLNHFRRIIW 237
Cdd:COG2319  186 VRLWDLATGKLLRtLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLA--------------TGKLLRTLTGHSGSVR 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771  238 CP-FIPEESedcceesspTVALLHEDR-AEVWDLDMLRSSHstwpvdvsqikqgfiVVKGHSTCLSEGALSPDGTVLATA 315
Cdd:COG2319  251 SVaFSPDGR---------LLASGSADGtVRLWDLATGELLR---------------TLTGHSGGVNSVAFSPDGKLLASG 306

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771  316 SHDGYVKFWQIyiegqDEPRCLHEWKPHDGRPLScLLFcdnhkkqDPDVpfwRFLITGADQNReLKMWCTVSWTCLQTIR 395
Cdd:COG2319  307 SDDGTVRLWDL-----ATGKLLRTLTGHTGAVRS-VAF-------SPDG---KTLASGSDDGT-VRLWDLATGELLRTLT 369

                        250
                 ....*....|....
gi 45827771  396 ----------FSPD 399
Cdd:COG2319  370 ghtgavtsvaFSPD 383
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 294-409 2.51e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.88  E-value: 2.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771  294 KGHSTCLSEGALSPDGTVLATASHDGYVKFWQIyiegqDEPRCLHEWKPHDGrPLSCLLFcdnhkkqDPDvpfwRFLITG 373
Cdd:cd00200   48 KGHTGPVRDVAASADGTYLASGSSDKTIRLWDL-----ETGECVRTLTGHTS-YVSSVAF-------SPD----GRILSS 110

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 45827771  374 ADQNRELKMWCTVSWTCLQTIRFSPDIFSSVSVPPS 409
Cdd:cd00200  111 SSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD 146
WD40 COG2319
WD40 repeat [General function prediction only];
159-399 3.39e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 3.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771  159 VRVISVSTSER-TLLKGFTGSVADLAFahlnSP---QLACLDEAGNLFVWRLAlvNGKIQEEILVHIRQ-------PEGT 227
Cdd:COG2319  102 VRLWDLATGLLlRTLTGHTGAVRSVAF----SPdgkTLASGSADGTVRLWDLA--TGKLLRTLTGHSGAvtsvafsPDGK 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771  228 plnhfrriiwcpfipeesedcceesspTVALLHEDR-AEVWDLDMLRSSHstwpvdvsqikqgfiVVKGHSTCLSEGALS 306
Cdd:COG2319  176 ---------------------------LLASGSDDGtVRLWDLATGKLLR---------------TLTGHTGAVRSVAFS 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771  307 PDGTVLATASHDGYVKFWQIyiegqDEPRCLHEWKPHDGRPLScLLFcdnhkkqDPDVpfwRFLITGaDQNRELKMWCTV 386
Cdd:COG2319  214 PDGKLLASGSADGTVRLWDL-----ATGKLLRTLTGHSGSVRS-VAF-------SPDG---RLLASG-SADGTVRLWDLA 276

                        250       260
                 ....*....|....*....|...
gi 45827771  387 SWTCLQT----------IRFSPD 399
Cdd:COG2319  277 TGELLRTltghsggvnsVAFSPD 299
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 172-399 1.42e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.57  E-value: 1.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771  172 LKGFTGSVADLAFaHLNSPQLACLDEAGNLFVWRLAlvNGKIQEEILVHIRQPegtplnhfRRIIWCPFipeesedccee 251
Cdd:cd00200    5 LKGHTGGVTCVAF-SPDGKLLATGSGDGTIKVWDLE--TGELLRTLKGHTGPV--------RDVAASAD----------- 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771  252 sSPTVALLHEDRA-EVWDLDMLRSSHstwpvdvsqikqgfiVVKGHSTCLSEGALSPDGTVLATASHDGYVKFWQIyieg 330
Cdd:cd00200   63 -GTYLASGSSDKTiRLWDLETGECVR---------------TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV---- 122

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45827771  331 qDEPRCLHEWKPHDGrPLSCLLFCDNHKkqdpdvpfwrfLITGADQNRELKMWCTVSWTCLQT----------IRFSPD 399
Cdd:cd00200  123 -ETGKCLTTLRGHTD-WVNSVAFSPDGT-----------FVASSSQDGTIKLWDLRTGKCVATltghtgevnsVAFSPD 188
WD40 COG2319
WD40 repeat [General function prediction only];
158-349 5.92e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.29  E-value: 5.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771  158 MVRVISVST-SERTLLKGFTGSVADLAFAHlNSPQLACLDEAGNLFVWRLAlvNGKIQEEILVHIRQ-------PEGTpl 229
Cdd:COG2319  227 TVRLWDLATgKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLA--TGELLRTLTGHSGGvnsvafsPDGK-- 301

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771  230 nhfrriiwcpfipeesedcceesspTVALLHEDR-AEVWDLDMLRSSHStwpvdvsqikqgfivVKGHSTCLSEGALSPD 308
Cdd:COG2319  302 -------------------------LLASGSDDGtVRLWDLATGKLLRT---------------LTGHTGAVRSVAFSPD 341

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 45827771  309 GTVLATASHDGYVKFWQIyiegqDEPRCLHEWKPHDGRPLS 349
Cdd:COG2319  342 GKTLASGSDDGTVRLWDL-----ATGELLRTLTGHTGAVTS 377
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 159-405 6.83e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.64  E-value: 6.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771  159 VRVISVSTSE-RTLLKGFTGSVADLAFaHLNSPQLACLDEAGNLFVWRLalvngkIQEEILVHIRQpegtplnHFRRIIW 237
Cdd:cd00200   33 IKVWDLETGElLRTLKGHTGPVRDVAA-SADGTYLASGSSDKTIRLWDL------ETGECVRTLTG-------HTSYVSS 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771  238 CPFIPEEsedcceessPTVALLHEDR-AEVWDLD-----MLRSSHSTWPVDVSQIKQGFIVV------------------ 293
Cdd:cd00200   99 VAFSPDG---------RILSSSSRDKtIKVWDVEtgkclTTLRGHTDWVNSVAFSPDGTFVAsssqdgtiklwdlrtgkc 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771  294 ----KGHSTCLSEGALSPDGTVLATASHDGYVKFWQIyiegqDEPRCLHEWKPHDGrPLSCLLFCDNhkkqdpdvpfwRF 369
Cdd:cd00200  170 vatlTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL-----STGKCLGTLRGHEN-GVNSVAFSPD-----------GY 232

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 45827771  370 LITGADQNRELKMWCTVSWTCLQTIR----------FSPDIFSSVS 405
Cdd:cd00200  233 LLASGSEDGTIRVWDLRTGECVQTLSghtnsvtslaWSPDGKRLAS 278
PHA03247 PHA03247
large tegument protein UL36; Provisional
 525-982 4.67e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 4.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771   525 PQLNPDVVAPLPTHTAHEDFTFGESRPELGSEGLGSAAHGSQpdlRRIVELPAPADFLSLSSETKPKLMTPDAFMTPSAS 604
Cdd:PHA03247 2713 HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGP---ARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVA 2789

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771   605 LQQITASPSSSSSGSSSSSSSSSSSLTAVSAMSSTSAVDPSLTRPPEELTLSPKLQLDGSLTMSSSgslqASPRGLLPGL 684
Cdd:PHA03247 2790 SLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGS----VAPGGDVRRR 2865

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771   685 LPAPADKLTPKGPGQVPTATSALSLELQEVEPLGLPQASPSRTRSPDvissastalsqdipeiasealsrgfgsSAPEGL 764
Cdd:PHA03247 2866 PPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQ---------------------------APPPPQ 2918

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771   765 EPDSMASAASALHLLSPRPRPGPELGPQLGLDGGPGDGDRHNTPSlLEAALTQEASTPDSQVWPTAPDITRETCST--LA 842
Cdd:PHA03247 2919 PQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPW-LGALVPGRVAVPRFRVPQPAPSREAPASSTppLT 2997

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771   843 ESPRNGLQEKHKSLAFHR----PPYHLLQQRDSQDasaeQSDHDDEVASLASASGGFGTKV-----PAPRLPAKDWKTKG 913
Cdd:PHA03247 2998 GHSLSRVSSWASSLALHEetdpPPVSLKQTLWPPD----DTEDSDADSLFDSDSERSDLEAldplpPEPHDPFAHEPDPA 3073

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45827771   914 SP----RTSPKLKRKSKKDDGDAAMGSRLTEHQVAEPPEDWPALIWQQQRELAELRHSqeeLLQRLCTQLEGL 982
Cdd:PHA03247 3074 TPeagaRESPSSQFGPPPLSANAALSRRYVRSTGRSALAVLIEACRRIRRQLRRTRHA---LLDRSGAVLTGL 3143
WD40 COG2319
WD40 repeat [General function prediction only];
151-326 3.35e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.90  E-value: 3.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771  151 AANNGSAMVRVISVSTSER-TLLKGFTGSVADLAFahlnSP---QLACLDEAGNLFVWRLAlvNGKIQEEILVHIRQPeg 226
Cdd:COG2319  262 ASGSADGTVRLWDLATGELlRTLTGHSGGVNSVAF----SPdgkLLASGSDDGTVRLWDLA--TGKLLRTLTGHTGAV-- 333

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771  227 tplnhfRRIIWCPfipeesedcceeSSPTVALLHEDR-AEVWDLDMLRSSHstwpvdvsqikqgfiVVKGHSTCLSEGAL 305
Cdd:COG2319  334 ------RSVAFSP------------DGKTLASGSDDGtVRLWDLATGELLR---------------TLTGHTGAVTSVAF 380

                        170       180
                 ....*....|....*....|.
gi 45827771  306 SPDGTVLATASHDGYVKFWQI 326
Cdd:COG2319  381 SPDGRTLASGSADGTVRLWDL 401
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 292-324 4.99e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 4.99e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 45827771     292 VVKGHS---TCLsegALSPDGTVLATASHDGYVKFW 324
Cdd:smart00320    7 TLKGHTgpvTSV---AFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
292-324 1.19e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 1.19e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 45827771    292 VVKGHS---TCLsegALSPDGTVLATASHDGYVKFW 324
Cdd:pfam00400    6 TLEGHTgsvTSL---AFSPDGKLLASGSDDGTVKVW 38
WD40 COG2319
WD40 repeat [General function prediction only];
272-399 1.29e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.98  E-value: 1.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827771  272 LRSSHSTWPVDVSQIKQGFIVVKGHSTCLSEGALSPDGTVLATASHDGYVKFWQIyiegqDEPRCLHEWKPHDGRPLSCL 351
Cdd:COG2319   53 AGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL-----ATGLLLRTLTGHTGAVRSVA 127

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 45827771  352 LfcdnhkkqDPDVpfwRFLITGADqNRELKMWCTVSWTCLQTIR----------FSPD 399
Cdd:COG2319  128 F--------SPDG---KTLASGSA-DGTVRLWDLATGKLLRTLTghsgavtsvaFSPD 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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