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Conserved domains on  [gi|7657633|ref|NP_055166|]
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sulfotransferase 4A1 [Homo sapiens]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
45-277 3.49e-68

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 212.20  E-value: 3.49e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657633     45 PSDVWIVTYPKSGTSLLQEVVYLVSQGADPD---EIGLMNIDEQLPVLE--------YPQPGLDIIKELTSPRLIKSHLP 113
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEkseEPHLFNNHNRSPFLEwypgdtyfDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657633    114 YRFLPSDLHNGDSKVIYMARNPKDLVVSYYQFHRSLRTMSYRGTFQEFCRRFMNDKLGYGSWFEHVQEFWEHRMDSNVLF 193
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657633    194 LKYEDMHRDLVTMVEQLARFLGVSCDKAQLEALTEHCHQLV---DQCCNAEALPVG------RGRVGLWKDIFTVSMNEK 264
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENmkgNPCLNYSKLPKEvspffrKGLVGDWKNYFTPEQAEK 240

                         250
                  ....*....|...
gi 7657633    265 FDLVYKQKMGKCD 277
Cdd:pfam00685 241 FDEIYQEKMKGTG 253
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
45-277 3.49e-68

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 212.20  E-value: 3.49e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657633     45 PSDVWIVTYPKSGTSLLQEVVYLVSQGADPD---EIGLMNIDEQLPVLE--------YPQPGLDIIKELTSPRLIKSHLP 113
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEkseEPHLFNNHNRSPFLEwypgdtyfDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657633    114 YRFLPSDLHNGDSKVIYMARNPKDLVVSYYQFHRSLRTMSYRGTFQEFCRRFMNDKLGYGSWFEHVQEFWEHRMDSNVLF 193
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657633    194 LKYEDMHRDLVTMVEQLARFLGVSCDKAQLEALTEHCHQLV---DQCCNAEALPVG------RGRVGLWKDIFTVSMNEK 264
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENmkgNPCLNYSKLPKEvspffrKGLVGDWKNYFTPEQAEK 240

                         250
                  ....*....|...
gi 7657633    265 FDLVYKQKMGKCD 277
Cdd:pfam00685 241 FDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 21-215 4.93e-23

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 96.53  E-value: 4.93e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657633    21 EFHGVR-LPPFCRGKMEEIANFPVRPSDVWIVTYPKSGTSLLQEVVYLVSQGADPDE----IGLMNIDEQLPVLE----- 90
Cdd:PLN02164  54 EYGGHWwLQPLLEGLLHAQEFFQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDssnpLLKRNPHEFVPYIEidfpf 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657633    91 YPQpgLDIIKELTSPrLIKSHLPYRFLPSDLHNGDSKVIYMARNPKDLVVSYYQFHRSLRT-----MSYRGTFQEFCRRF 165
Cdd:PLN02164 134 FPS--VDVLKDKGNT-LFSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSqqgplNSLEESFDMFCRGL 210

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 7657633   166 MndklGYGSWFEHVQEFWEHRMDS--NVLFLKYEDMHRDLVTMVEQLARFLG 215
Cdd:PLN02164 211 S----VYGPYLDHVLGYWKAYQENpdRILFLKYETMRADPLPYVKRLAEFMG 258
LpsS COG4424
LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];
106-228 3.95e-03

LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443539  Cd Length: 238  Bit Score: 37.68  E-value: 3.95e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657633  106 RLIKSHLPY---RFLPSDLHNGDSKVIYMARNpkDLV---VSYY------QFHRS-------LRTMSYRgtFQEFCRrfm 166
Cdd:COG4424  81 KLFWDQLPRllqRALRLLAAFPDLKFIHLTRR--DKLaqaVSLViaqqtgQWHSDaddalapTAPPEYD--AEEIAR--- 153

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7657633  167 ndklgygsWFEHVQEF---WEHRMDSN---VLFLKYEDMHRDLVTMVEQLARFLGVSCDKAQLEALTE 228
Cdd:COG4424 154 --------LLEALQDFearWEAWFARTgitPLEITYEDLAADPVEVLNRVLDFLGVDPPLAPLRPALK 213
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
45-277 3.49e-68

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 212.20  E-value: 3.49e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657633     45 PSDVWIVTYPKSGTSLLQEVVYLVSQGADPD---EIGLMNIDEQLPVLE--------YPQPGLDIIKELTSPRLIKSHLP 113
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEkseEPHLFNNHNRSPFLEwypgdtyfDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657633    114 YRFLPSDLHNGDSKVIYMARNPKDLVVSYYQFHRSLRTMSYRGTFQEFCRRFMNDKLGYGSWFEHVQEFWEHRMDSNVLF 193
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657633    194 LKYEDMHRDLVTMVEQLARFLGVSCDKAQLEALTEHCHQLV---DQCCNAEALPVG------RGRVGLWKDIFTVSMNEK 264
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENmkgNPCLNYSKLPKEvspffrKGLVGDWKNYFTPEQAEK 240

                         250
                  ....*....|...
gi 7657633    265 FDLVYKQKMGKCD 277
Cdd:pfam00685 241 FDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 21-215 4.93e-23

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 96.53  E-value: 4.93e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657633    21 EFHGVR-LPPFCRGKMEEIANFPVRPSDVWIVTYPKSGTSLLQEVVYLVSQGADPDE----IGLMNIDEQLPVLE----- 90
Cdd:PLN02164  54 EYGGHWwLQPLLEGLLHAQEFFQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDssnpLLKRNPHEFVPYIEidfpf 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657633    91 YPQpgLDIIKELTSPrLIKSHLPYRFLPSDLHNGDSKVIYMARNPKDLVVSYYQFHRSLRT-----MSYRGTFQEFCRRF 165
Cdd:PLN02164 134 FPS--VDVLKDKGNT-LFSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSqqgplNSLEESFDMFCRGL 210

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 7657633   166 MndklGYGSWFEHVQEFWEHRMDS--NVLFLKYEDMHRDLVTMVEQLARFLG 215
Cdd:PLN02164 211 S----VYGPYLDHVLGYWKAYQENpdRILFLKYETMRADPLPYVKRLAEFMG 258
Sulfotransfer_3 pfam13469
Sulfotransferase family;
50-216 7.93e-11

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 59.61  E-value: 7.93e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657633     50 IVTYPKSGTSLLQEVVylvsqGADPDEIGLM----NIDEQLPVLEYPQPGLDIIKELTSP--RLIK---SHLPY-----R 115
Cdd:pfam13469   3 IVGLPRSGTTLLHRLL-----AAHPDVRPPEetwfVIPRILALLQAWGKSLEALARVPSYarWLCDkspSHLFHldlllK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657633    116 FLPsdlhngDSKVIYMARNPKDLVV-SYYQFHRSLRTmSYRGTFQEFCRRFMNDklgygsWFEHVQEFWEHRM---DSNV 191
Cdd:pfam13469  78 AFP------DAKFIHLHRDPVDTVIsSYCSLFGFTLS-SYSTAFLRDIGLALAR------WSRAYERLMAARArvpPGRF 144

                         170       180
                  ....*....|....*....|....*
gi 7657633    192 LFLKYEDMHRDLVTMVEQLARFLGV 216
Cdd:pfam13469 145 LDVRYEDLVADPEGTLRRILEFLGL 169
LpsS COG4424
LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];
106-228 3.95e-03

LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443539  Cd Length: 238  Bit Score: 37.68  E-value: 3.95e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657633  106 RLIKSHLPY---RFLPSDLHNGDSKVIYMARNpkDLV---VSYY------QFHRS-------LRTMSYRgtFQEFCRrfm 166
Cdd:COG4424  81 KLFWDQLPRllqRALRLLAAFPDLKFIHLTRR--DKLaqaVSLViaqqtgQWHSDaddalapTAPPEYD--AEEIAR--- 153

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7657633  167 ndklgygsWFEHVQEF---WEHRMDSN---VLFLKYEDMHRDLVTMVEQLARFLGVSCDKAQLEALTE 228
Cdd:COG4424 154 --------LLEALQDFearWEAWFARTgitPLEITYEDLAADPVEVLNRVLDFLGVDPPLAPLRPALK 213
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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