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Conserved domains on  [gi|7657530|ref|NP_055248|]
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radial spoke head 14 homolog [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 220-255 2.68e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


:

Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 37.82  E-value: 2.68e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 7657530    220 SREGKKQVCHFDVIPILVHLLKDPVEHVKSNAAGAL 255
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWAL 36
HEAT COG1413
HEAT repeat [General function prediction only];
183-303 4.60e-04

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.00  E-value: 4.60e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657530  183 ATEALG----SNVVLVLKQKLLSANQNIRSKAARALlnvsisregkKQVCHFDVIPILVHLLKDPVEHVKSNAAGALmfa 258
Cdd:COG1413   5 AARALGrlgdPAAVPALIAALADEDPDVRAAAARAL----------GRLGDPRAVPALLEALKDPDPEVRAAAAEAL--- 71

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 7657530  259 tviteGKYAAleAQAIGLLLELLHSPMTIARLNATKALTMLAEAP 303
Cdd:COG1413  72 -----GRIGD--PEAVPALIAALKDEDPEVRRAAAEALGRLGDPA 109
 
Name Accession Description Interval E-value
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 220-255 2.68e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 37.82  E-value: 2.68e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 7657530    220 SREGKKQVCHFDVIPILVHLLKDPVEHVKSNAAGAL 255
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWAL 36
HEAT COG1413
HEAT repeat [General function prediction only];
183-303 4.60e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.00  E-value: 4.60e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657530  183 ATEALG----SNVVLVLKQKLLSANQNIRSKAARALlnvsisregkKQVCHFDVIPILVHLLKDPVEHVKSNAAGALmfa 258
Cdd:COG1413   5 AARALGrlgdPAAVPALIAALADEDPDVRAAAARAL----------GRLGDPRAVPALLEALKDPDPEVRAAAAEAL--- 71

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 7657530  259 tviteGKYAAleAQAIGLLLELLHSPMTIARLNATKALTMLAEAP 303
Cdd:COG1413  72 -----GRIGD--PEAVPALIAALKDEDPEVRRAAAEALGRLGDPA 109
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 220-255 3.67e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 34.71  E-value: 3.67e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 7657530     220 SREGKKQVCHFDVIPILVHLLKDPVEHVKSNAAGAL 255
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWAL 36
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 192-296 8.33e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 35.01  E-value: 8.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657530    192 VLVLKQKLL-SANQNIRSKAARALlnvsisregkKQVCHFDVIPILVHLLKDPVEHVKSNAAGALMFATvitegkyaalE 270
Cdd:pfam13646   1 LPALLQALLrDPDPEVRAAAIRAL----------GRIGDPEAVPALLELLKDEDPAVRRAAAEALGKIG----------D 60

                          90       100
                  ....*....|....*....|....*..
gi 7657530    271 AQAIGLLLELL-HSPMTIARLNATKAL 296
Cdd:pfam13646  61 PEALPALLELLrDDDDDVVRAAAAEAL 87
 
Name Accession Description Interval E-value
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 220-255 2.68e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 37.82  E-value: 2.68e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 7657530    220 SREGKKQVCHFDVIPILVHLLKDPVEHVKSNAAGAL 255
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWAL 36
HEAT COG1413
HEAT repeat [General function prediction only];
183-303 4.60e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.00  E-value: 4.60e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657530  183 ATEALG----SNVVLVLKQKLLSANQNIRSKAARALlnvsisregkKQVCHFDVIPILVHLLKDPVEHVKSNAAGALmfa 258
Cdd:COG1413   5 AARALGrlgdPAAVPALIAALADEDPDVRAAAARAL----------GRLGDPRAVPALLEALKDPDPEVRAAAAEAL--- 71

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 7657530  259 tviteGKYAAleAQAIGLLLELLHSPMTIARLNATKALTMLAEAP 303
Cdd:COG1413  72 -----GRIGD--PEAVPALIAALKDEDPEVRRAAAEALGRLGDPA 109
HEAT COG1413
HEAT repeat [General function prediction only];
180-296 1.01e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 38.84  E-value: 1.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657530  180 QEDATEALG----SNVVLVLKQKLLSANQNIRSKAARALLNVSISRegkkqvchfdVIPILVHLLKDPVEHVKSNAAGAL 255
Cdd:COG1413  33 RAAAARALGrlgdPRAVPALLEALKDPDPEVRAAAAEALGRIGDPE----------AVPALIAALKDEDPEVRRAAAEAL 102

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 7657530  256 mfatvitegkYAALEAQAIGLLLELLHSPMTIARLNATKAL 296
Cdd:COG1413 103 ----------GRLGDPAAVPALLEALKDPDWEVRRAAARAL 133
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 220-255 3.67e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 34.71  E-value: 3.67e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 7657530     220 SREGKKQVCHFDVIPILVHLLKDPVEHVKSNAAGAL 255
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWAL 36
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 192-296 8.33e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 35.01  E-value: 8.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657530    192 VLVLKQKLL-SANQNIRSKAARALlnvsisregkKQVCHFDVIPILVHLLKDPVEHVKSNAAGALMFATvitegkyaalE 270
Cdd:pfam13646   1 LPALLQALLrDPDPEVRAAAIRAL----------GRIGDPEAVPALLELLKDEDPAVRRAAAEALGKIG----------D 60

                          90       100
                  ....*....|....*....|....*..
gi 7657530    271 AQAIGLLLELL-HSPMTIARLNATKAL 296
Cdd:pfam13646  61 PEALPALLELLrDDDDDVVRAAAAEAL 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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