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Conserved domains on  [gi|41281429|ref|NP_055485|]
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eIF5-mimic protein 2 isoform 4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
W2 super family cl17013
C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of ...
 217-340 1.99e-50

C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of several translation initiation factors, including the epsilon chain of eIF2b, where it has been found to catalyze the conversion of eIF2.GDP to its active eIF2.GTP form. The structure of the domain resembles that of a set of concatenated HEAT repeats.


The actual alignment was detected with superfamily member cd11560:

Pssm-ID: 473053 [Multi-domain]  Cd Length: 194  Bit Score: 166.62  E-value: 1.99e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281429 217 ELFPANKQSVEHFTKYFTEAGLKELSEYVRNQQTIGARKELQKELQEQMSRGDPFKDIILYVKEEMKKN----------- 285
Cdd:cd11560   1 EFFPPNKRTEEHFAEHFKEEGLDELVEFYRKQASQEIKKELQQELKEMIAEEEPVKEIIAAVKEQMKKSslpehevvgll 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281429 286 -------------------------------------------------------NIHFMKAFQKIVVLFYKAEVLSEEP 310
Cdd:cd11560  81 wtalmdavewskkedqiaeqalrhlkkyapllaafcttaraelallnkiqeycyeNMKFMKVFQKIVKLLYKADVLSEDA 160

                       170       180       190
                ....*....|....*....|....*....|
gi 41281429 311 ILKWYKDAHVAKGKSVFLEQMKKFVEWLKN 340
Cdd:cd11560 161 ILKWYKKGHSPKGKQVFLKQMEPFVEWLQE 190
 
Name Accession Description Interval E-value
W2_eIF5C_like cd11560
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; ...
 217-340 1.99e-50

C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; eIF5C appears to be essential for the initiation of protein translation; its actual function, and specifically that of the C-terminal W2 domain, are not well understood. The Drosophila ortholog, kra (krasavietz) or exba (extra bases), may be involved in translational inhibition in neural development. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211398 [Multi-domain]  Cd Length: 194  Bit Score: 166.62  E-value: 1.99e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281429 217 ELFPANKQSVEHFTKYFTEAGLKELSEYVRNQQTIGARKELQKELQEQMSRGDPFKDIILYVKEEMKKN----------- 285
Cdd:cd11560   1 EFFPPNKRTEEHFAEHFKEEGLDELVEFYRKQASQEIKKELQQELKEMIAEEEPVKEIIAAVKEQMKKSslpehevvgll 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281429 286 -------------------------------------------------------NIHFMKAFQKIVVLFYKAEVLSEEP 310
Cdd:cd11560  81 wtalmdavewskkedqiaeqalrhlkkyapllaafcttaraelallnkiqeycyeNMKFMKVFQKIVKLLYKADVLSEDA 160

                       170       180       190
                ....*....|....*....|....*....|
gi 41281429 311 ILKWYKDAHVAKGKSVFLEQMKKFVEWLKN 340
Cdd:cd11560 161 ILKWYKKGHSPKGKQVFLKQMEPFVEWLQE 190
eIF5C smart00515
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
276-340 7.04e-18

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;


Pssm-ID: 214705  Cd Length: 83  Bit Score: 77.33  E-value: 7.04e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41281429    276 LYVKEEMKKNNIHFMKAFQKIVVLFYKAEVLSEEPILKWYKDAHVAKGKSVFLEQMKKFVEWLKN 340
Cdd:smart00515  18 LYAIEEFCVELEKLGKLLPKILKSLYDADILEEEAILKWYEKAVSAEGKKKVRKNAKPFVTWLQE 82
W2 pfam02020
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ...
 272-340 1.52e-13

eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.


Pssm-ID: 460415  Cd Length: 76  Bit Score: 65.24  E-value: 1.52e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281429   272 KDIILYVkEEMKKNNIHFMKAFQKIVVLFYKAEVLSEEPILKWYKDAH-VAKGKSVFLEQMKKFVEWLKN 340
Cdd:pfam02020   2 VDLLLAL-QEFCAKLEELLKLLLKILKALYDLDIVEEEAILKWWEDVSsAEKGMKKVRKQAKPFVEWLEE 70
 
Name Accession Description Interval E-value
W2_eIF5C_like cd11560
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; ...
 217-340 1.99e-50

C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; eIF5C appears to be essential for the initiation of protein translation; its actual function, and specifically that of the C-terminal W2 domain, are not well understood. The Drosophila ortholog, kra (krasavietz) or exba (extra bases), may be involved in translational inhibition in neural development. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211398 [Multi-domain]  Cd Length: 194  Bit Score: 166.62  E-value: 1.99e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281429 217 ELFPANKQSVEHFTKYFTEAGLKELSEYVRNQQTIGARKELQKELQEQMSRGDPFKDIILYVKEEMKKN----------- 285
Cdd:cd11560   1 EFFPPNKRTEEHFAEHFKEEGLDELVEFYRKQASQEIKKELQQELKEMIAEEEPVKEIIAAVKEQMKKSslpehevvgll 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281429 286 -------------------------------------------------------NIHFMKAFQKIVVLFYKAEVLSEEP 310
Cdd:cd11560  81 wtalmdavewskkedqiaeqalrhlkkyapllaafcttaraelallnkiqeycyeNMKFMKVFQKIVKLLYKADVLSEDA 160

                       170       180       190
                ....*....|....*....|....*....|
gi 41281429 311 ILKWYKDAHVAKGKSVFLEQMKKFVEWLKN 340
Cdd:cd11560 161 ILKWYKKGHSPKGKQVFLKQMEPFVEWLQE 190
eIF5C smart00515
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
276-340 7.04e-18

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;


Pssm-ID: 214705  Cd Length: 83  Bit Score: 77.33  E-value: 7.04e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41281429    276 LYVKEEMKKNNIHFMKAFQKIVVLFYKAEVLSEEPILKWYKDAHVAKGKSVFLEQMKKFVEWLKN 340
Cdd:smart00515  18 LYAIEEFCVELEKLGKLLPKILKSLYDADILEEEAILKWYEKAVSAEGKKKVRKNAKPFVTWLQE 82
W2 pfam02020
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ...
 272-340 1.52e-13

eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.


Pssm-ID: 460415  Cd Length: 76  Bit Score: 65.24  E-value: 1.52e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281429   272 KDIILYVkEEMKKNNIHFMKAFQKIVVLFYKAEVLSEEPILKWYKDAH-VAKGKSVFLEQMKKFVEWLKN 340
Cdd:pfam02020   2 VDLLLAL-QEFCAKLEELLKLLLKILKALYDLDIVEEEAILKWWEDVSsAEKGMKKVRKQAKPFVEWLEE 70
W2_eIF2B_epsilon cd11558
C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a ...
 261-340 8.27e-10

C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a heteropentameric complex which functions as a guanine nucleotide exchange factor in the recycling of eIF-2 during the initiation of translation in eukaryotes. The epsilon and gamma subunits are sequence similar and both are essential in yeast. Epsilon appears to be the catalytically active subunit, with gamma enhancing its activity. The C-terminal domain of the eIF2B epsilon subunit contains bipartite motifs rich in acidic and aromatic residues, which are responsible for the interaction with eIF2. The structure of the domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211396  Cd Length: 169  Bit Score: 57.27  E-value: 8.27e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281429 261 LQEQMSRGDPFKDIILYVkEEMKKNNIHFMKAFQKIVVLFYKAEVLSEEPILKWYK--DAHVAKGKSVFLEQMKKFVEWL 338
Cdd:cd11558  83 LENYVKSQDDQVELLLAL-EEFCLESEEGGPLFAKLLHALYDLDILEEEAILEWWEepDAGADEEMKKVRELVKKFIEWL 161


                ..
gi 41281429 339 KN 340
Cdd:cd11558 162 EE 163
W2 cd11473
C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of ...
 167-315 3.87e-09

C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of several translation initiation factors, including the epsilon chain of eIF2b, where it has been found to catalyze the conversion of eIF2.GDP to its active eIF2.GTP form. The structure of the domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211395  Cd Length: 135  Bit Score: 54.40  E-value: 3.87e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41281429 167 ILNSLYNENLVKEGVSAafavklfkswiNEKDINAVAASLRKVSMDNRlmelfpankqSVEHFTKYFTEAGL-----KEL 241
Cdd:cd11473   1 EKNKKLRDSLLKELEED-----------KSSDVESVKAAKSKLDLDPI----------SLEEVVKVLLTAVVnavesADS 59

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41281429 242 SEYVRNQQTIGARKELQKELQEQMSRGDPFKDIILYVKEEM--KKNNIHFMKAFQKIVVLFYKAEVLSEEPILKWY 315
Cdd:cd11473  60 ISLTQKEQLVLVLKKYGPVLRELLKLIKKDQLYLLLKIEKLclQLKLSELISLLEKILDLLYDADVLSEEAILSWF 135
W2_eIF5 cd11561
C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase ...
 289-340 2.12e-05

C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase acceleration protein (GAP), as well as a GDP dissociation inhibitor (GDI) during translational initiation in eukaryotes. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211399  Cd Length: 157  Bit Score: 44.14  E-value: 2.12e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 41281429 289 FMKAFQKIVVLFYKAEVLSEEPILKWYKDA---HVAKGKS-VFLEQMKKFVEWLKN 340
Cdd:cd11561  96 LLKKVPLILKALYDNDILEEEVILKWYEKVskkYVSKEKSkKVRKAAEPFVEWLEE 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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