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Conserved domains on  [gi|270288733|ref|NP_055513|]
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CSC1-like protein 1 [Homo sapiens]

Protein Classification

OSCA/TMEM63 family ion channel( domain architecture ID 10342091)

OSCA/TMEM63 family ion channel is an an osmosensitive calcium-permeable cation channel that converts mechanical stimuli into electric signals

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RSN1_7TM pfam02714
Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane ...
439-692 9.22e-59

Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane domain region of putative phosphate transporter. The family is the 7TM region of osmosensitive calcium-permeable cation channels.


:

Pssm-ID: 460661  Cd Length: 273  Bit Score: 201.21  E-value: 9.22e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733  439 PSIILSTMDKFNVTKPIHALNNPI----------ISQFFPTLLLWSFSALLPSIVYYSTLLESHWTKSGENQIMMTKVYI 508
Cdd:pfam02714  19 PVAFVGLLSNLETLTKVWPFLKWIlelppkllglVTGLLPPLLLSLLMALLPIILRFLSKLQGAPSRSDIELSVQSKYFA 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733  509 FLIFMVLILPSLGLTSLDFffrWLFDKTSSEASIRLECVFLPDQGAFFVNYVIASAFIGNGMELLRLPGLILYTFRMIMA 588
Cdd:pfam02714  99 FLVVNVFLVFTLASSASSL---IEQIIDNPTSIPTLLATNLPKASNFFITYILLQGLSGAAGELLQLGPLILFYIKRKFL 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733  589 KTAADRRNVKQNQAFQYEFGAMYAWMLCVFTVIVAYSITCPIIAPFGLIYILLKHMVDRHNLYFVYLPAKLEKGIHF-AA 667
Cdd:pfam02714 176 DKTPRDKYERYTTPPSFDYGTVYPVFLLIFTIGLIYSVIAPLILPFGLVYFGLGYFVYKYQLLYVYVTKYESGGRFWpRA 255
                         250       260
                  ....*....|....*....|....*
gi 270288733  668 VNQalaapilCLFWLYFFSFLRLGM 692
Cdd:pfam02714 256 LNR-------LLVGLYLFQLCLIGL 273
PHM7_cyt pfam14703
Cytosolic domain of 10TM putative phosphate transporter; PHM7_cyt is the predicted cytosolic ...
228-410 3.13e-50

Cytosolic domain of 10TM putative phosphate transporter; PHM7_cyt is the predicted cytosolic domain of integral membrane proteins, such as yeast PHM7 and TM63A_HUMAN TRANSMEMBRANE PROTEIN 63A, SwissProt:O94886. This domain usually precedes the 7TM region, pfam02714, and follows a RSN1_TM, pfam13967. Fold recognition programs consistently and with high significance predict this domain to be distantly homologous to RNA binding proteins from the RRM clan.


:

Pssm-ID: 464272  Cd Length: 164  Bit Score: 173.66  E-value: 3.13e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733  228 RTLFITGLPRDAR-KETVESHFRDAYPTCEVVDVQLCYNVAKLIYLCKEKKKTEKSLTYYTNLQVKTGQRtlINPKPCGQ 306
Cdd:pfam14703   2 RTVLVTGIPKDLRsEEKLRSFFEELYPGTVVERVQIVRDVKKLPKLVEEREKAVRKLEAALAKYLKNGKK--PKKRPTHK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733  307 FCCCEVLGcEWEDAISYYTRMKDRLLERITEEERHVQDQPLGMAFVTFQEKSMATYILKdfnackcqslqckgepqpSSH 386
Cdd:pfam14703  80 LGFLGLFG-KKVDAIDYYTEKLEELEEEIEEEREKVDKKPLGAAFVTFKSERSAAAAAA------------------QIN 140
                         170       180
                  ....*....|....*....|....
gi 270288733  387 SRELYTSKWTVTFAADPEDICWKN 410
Cdd:pfam14703 141 PQLMHPKGWTVELAPEPRDVIWEN 164
RSN1_TM super family cl16507
Late exocytosis, associated with Golgi transport; This family represents the first three ...
52-210 1.81e-14

Late exocytosis, associated with Golgi transport; This family represents the first three transmembrane regions of 11-TM proteins involved in vesicle transport. In S. cerevisiae these proteins are members of the yeast facilitator superfamily and are integral membrane proteins localized to the cell periphery, in particular to the bud-neck region. The distribution is consistent with a role in late exocytosis which is in agreement with the proteins' ability to substitute for the function of Sro7p, required for the sorting of the protein Enap1 into Golgi-derived vesicles destined for the cell surface.


The actual alignment was detected with superfamily member pfam13967:

Pssm-ID: 433613  Cd Length: 158  Bit Score: 71.45  E-value: 1.81e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733   52 TVLLIDVSCFLFLILVFSIIRRRFWD--YGRIALVSEadsESRFQRLSSTSSSGqqdfenelgccpWLTAIFRLHDDQIL 129
Cdd:pfam13967   4 TSLVINLVIALVFLLLFSILRPKNKRvyAPRTYLAPE---EERTPPLPGTGLFG------------WIPPLLKIPDEEIL 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733  130 EWCGEDAIHYLSFQRHIIFLLVVVSFLSLCVILPVNLSGDLLDKDPYSFGRT-----TIANLQTDNDLLWLHTIFAVIYL 204
Cdd:pfam13967  69 QHAGLDAYVFLRFLKMLIKIFLVGCLIGWPILLPVNATGGNGEDDGDSLTRTgldklSSSNNVEGSNRLWAHVVVAYIFT 148

                  ....*.
gi 270288733  205 FLTVGF 210
Cdd:pfam13967 149 GFVLYL 154
 
Name Accession Description Interval E-value
RSN1_7TM pfam02714
Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane ...
439-692 9.22e-59

Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane domain region of putative phosphate transporter. The family is the 7TM region of osmosensitive calcium-permeable cation channels.


Pssm-ID: 460661  Cd Length: 273  Bit Score: 201.21  E-value: 9.22e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733  439 PSIILSTMDKFNVTKPIHALNNPI----------ISQFFPTLLLWSFSALLPSIVYYSTLLESHWTKSGENQIMMTKVYI 508
Cdd:pfam02714  19 PVAFVGLLSNLETLTKVWPFLKWIlelppkllglVTGLLPPLLLSLLMALLPIILRFLSKLQGAPSRSDIELSVQSKYFA 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733  509 FLIFMVLILPSLGLTSLDFffrWLFDKTSSEASIRLECVFLPDQGAFFVNYVIASAFIGNGMELLRLPGLILYTFRMIMA 588
Cdd:pfam02714  99 FLVVNVFLVFTLASSASSL---IEQIIDNPTSIPTLLATNLPKASNFFITYILLQGLSGAAGELLQLGPLILFYIKRKFL 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733  589 KTAADRRNVKQNQAFQYEFGAMYAWMLCVFTVIVAYSITCPIIAPFGLIYILLKHMVDRHNLYFVYLPAKLEKGIHF-AA 667
Cdd:pfam02714 176 DKTPRDKYERYTTPPSFDYGTVYPVFLLIFTIGLIYSVIAPLILPFGLVYFGLGYFVYKYQLLYVYVTKYESGGRFWpRA 255
                         250       260
                  ....*....|....*....|....*
gi 270288733  668 VNQalaapilCLFWLYFFSFLRLGM 692
Cdd:pfam02714 256 LNR-------LLVGLYLFQLCLIGL 273
PHM7_cyt pfam14703
Cytosolic domain of 10TM putative phosphate transporter; PHM7_cyt is the predicted cytosolic ...
228-410 3.13e-50

Cytosolic domain of 10TM putative phosphate transporter; PHM7_cyt is the predicted cytosolic domain of integral membrane proteins, such as yeast PHM7 and TM63A_HUMAN TRANSMEMBRANE PROTEIN 63A, SwissProt:O94886. This domain usually precedes the 7TM region, pfam02714, and follows a RSN1_TM, pfam13967. Fold recognition programs consistently and with high significance predict this domain to be distantly homologous to RNA binding proteins from the RRM clan.


Pssm-ID: 464272  Cd Length: 164  Bit Score: 173.66  E-value: 3.13e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733  228 RTLFITGLPRDAR-KETVESHFRDAYPTCEVVDVQLCYNVAKLIYLCKEKKKTEKSLTYYTNLQVKTGQRtlINPKPCGQ 306
Cdd:pfam14703   2 RTVLVTGIPKDLRsEEKLRSFFEELYPGTVVERVQIVRDVKKLPKLVEEREKAVRKLEAALAKYLKNGKK--PKKRPTHK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733  307 FCCCEVLGcEWEDAISYYTRMKDRLLERITEEERHVQDQPLGMAFVTFQEKSMATYILKdfnackcqslqckgepqpSSH 386
Cdd:pfam14703  80 LGFLGLFG-KKVDAIDYYTEKLEELEEEIEEEREKVDKKPLGAAFVTFKSERSAAAAAA------------------QIN 140
                         170       180
                  ....*....|....*....|....
gi 270288733  387 SRELYTSKWTVTFAADPEDICWKN 410
Cdd:pfam14703 141 PQLMHPKGWTVELAPEPRDVIWEN 164
COG5594 COG5594
Uncharacterized integral membrane protein [Function unknown];
49-654 1.02e-28

Uncharacterized integral membrane protein [Function unknown];


Pssm-ID: 227881 [Multi-domain]  Cd Length: 827  Bit Score: 123.30  E-value: 1.02e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733  49 GIPTVLLIDVSCFLFLILVFSIIRRRF-WDYgrialvsEADSESRFQRLSSTSSSGQQDFEnelgccpWLTAIFRLHDDQ 127
Cdd:COG5594   23 AVITQLVFAGLIFLVFLILFLILRKRWkRLY-------APRTNFDGQNECLPEPNPSSYWG-------WLEPLVKIPDEF 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733 128 ILEWCGEDAIHYLSFQRHIIFLLVVVSFLSLCVILPVN---LSGDLLDKDPYS-FGRTTIANLQTDNDLlWLHtIFAVIY 203
Cdd:COG5594   89 LLQYAGLDGYFFLRFLKMLIKLLFILSLILIPILLPVNyhfQKATNGNSDSESgLDKLSISNVSPSNRL-YAH-VFLSWF 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733 204 LFLTVGF-----------MRHHT-------QSIKYKEENLVRRTLFITGLPRDARKETVESHFRDAYPTCEVVDVQLCYN 265
Cdd:COG5594  167 FFGYVLFiifrelrfyvvLRQAYlrsplyqQSLLTLQNNLSSRTVLISGLPSELRSDEELKELFDKLKVGEIDSDVLCRD 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733 266 VAKLIYLCKEK----KKTEKSLTYYTNLQVK-TGQRTLINPKPCGQFCCCEV-----------------------LGCEW 317
Cdd:COG5594  247 LGTLQELYKERdkilKKLEKALNELLNKLLKkSHLKTNKKSGKLTPSRKKEFeilpeyvpdkkrpkhrikklnkgIFGKK 326
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733 318 EDAISYYTRMKDRLLERITE-EERHVQDQPLGMAFVTFqeKSMATYilkdfNACKcqslqckgepQPSSHSRELYTSKwt 396
Cdd:COG5594  327 VDAIDYYSAKLTKLDAEIENaRKSLYENTPTKSGFITF--KSQASA-----QIAA----------QSQIYSRVLGKLK-- 387
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733 397 VTFAADPEDICWKNLSIQglRWW--LQWLGINFTLFLGLFFLTTPSIILSTMDKFN-VTKPIHALN---------NPIIS 464
Cdd:COG5594  388 VEIAPAPNDIIWDNLRLS--RKErlFKRISANILFILLIILWAFPVAFVGTISNLNtLSSLWPFLKfilkdppflAGILT 465
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733 465 QFFPTLLLWSFSALLPSIVYYSTLLESHWTKSGENQIMMTKVYIFL---IFMVLILPSLGLTSLDfffRWLFDKTSSEAS 541
Cdd:COG5594  466 GLLPTVALSLLMSIVPYFIRWLSYMQGLVSYSEEEIYVQNKYFAFLfvnLFLVVTLASSFSSIVW---SLLKEPTSIMTL 542
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733 542 IRLEcvfLPDQGAFFVNYVIASAFIGNGMELLRLPGLILYTFRM-IMAKTAADRRNvKQNQAFQYEFGAMYAWMLCVFTV 620
Cdd:COG5594  543 LANN---LPKASNFFISYIILQGLSGFPGTLLQIVPLLLSLVLGkFKDSTPRQKWN-RLETPPSFQFGTVLPQPILLFTI 618
                        650       660       670
                 ....*....|....*....|....*....|....
gi 270288733 621 IVAYSITCPIIAPFGLIYILLKHMVDRHNLYFVY 654
Cdd:COG5594  619 TICYSIISPLILLFGAVYFILNYLAYKYNLIYVS 652
RSN1_TM pfam13967
Late exocytosis, associated with Golgi transport; This family represents the first three ...
52-210 1.81e-14

Late exocytosis, associated with Golgi transport; This family represents the first three transmembrane regions of 11-TM proteins involved in vesicle transport. In S. cerevisiae these proteins are members of the yeast facilitator superfamily and are integral membrane proteins localized to the cell periphery, in particular to the bud-neck region. The distribution is consistent with a role in late exocytosis which is in agreement with the proteins' ability to substitute for the function of Sro7p, required for the sorting of the protein Enap1 into Golgi-derived vesicles destined for the cell surface.


Pssm-ID: 433613  Cd Length: 158  Bit Score: 71.45  E-value: 1.81e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733   52 TVLLIDVSCFLFLILVFSIIRRRFWD--YGRIALVSEadsESRFQRLSSTSSSGqqdfenelgccpWLTAIFRLHDDQIL 129
Cdd:pfam13967   4 TSLVINLVIALVFLLLFSILRPKNKRvyAPRTYLAPE---EERTPPLPGTGLFG------------WIPPLLKIPDEEIL 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733  130 EWCGEDAIHYLSFQRHIIFLLVVVSFLSLCVILPVNLSGDLLDKDPYSFGRT-----TIANLQTDNDLLWLHTIFAVIYL 204
Cdd:pfam13967  69 QHAGLDAYVFLRFLKMLIKIFLVGCLIGWPILLPVNATGGNGEDDGDSLTRTgldklSSSNNVEGSNRLWAHVVVAYIFT 148

                  ....*.
gi 270288733  205 FLTVGF 210
Cdd:pfam13967 149 GFVLYL 154
 
Name Accession Description Interval E-value
RSN1_7TM pfam02714
Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane ...
439-692 9.22e-59

Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane domain region of putative phosphate transporter. The family is the 7TM region of osmosensitive calcium-permeable cation channels.


Pssm-ID: 460661  Cd Length: 273  Bit Score: 201.21  E-value: 9.22e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733  439 PSIILSTMDKFNVTKPIHALNNPI----------ISQFFPTLLLWSFSALLPSIVYYSTLLESHWTKSGENQIMMTKVYI 508
Cdd:pfam02714  19 PVAFVGLLSNLETLTKVWPFLKWIlelppkllglVTGLLPPLLLSLLMALLPIILRFLSKLQGAPSRSDIELSVQSKYFA 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733  509 FLIFMVLILPSLGLTSLDFffrWLFDKTSSEASIRLECVFLPDQGAFFVNYVIASAFIGNGMELLRLPGLILYTFRMIMA 588
Cdd:pfam02714  99 FLVVNVFLVFTLASSASSL---IEQIIDNPTSIPTLLATNLPKASNFFITYILLQGLSGAAGELLQLGPLILFYIKRKFL 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733  589 KTAADRRNVKQNQAFQYEFGAMYAWMLCVFTVIVAYSITCPIIAPFGLIYILLKHMVDRHNLYFVYLPAKLEKGIHF-AA 667
Cdd:pfam02714 176 DKTPRDKYERYTTPPSFDYGTVYPVFLLIFTIGLIYSVIAPLILPFGLVYFGLGYFVYKYQLLYVYVTKYESGGRFWpRA 255
                         250       260
                  ....*....|....*....|....*
gi 270288733  668 VNQalaapilCLFWLYFFSFLRLGM 692
Cdd:pfam02714 256 LNR-------LLVGLYLFQLCLIGL 273
PHM7_cyt pfam14703
Cytosolic domain of 10TM putative phosphate transporter; PHM7_cyt is the predicted cytosolic ...
228-410 3.13e-50

Cytosolic domain of 10TM putative phosphate transporter; PHM7_cyt is the predicted cytosolic domain of integral membrane proteins, such as yeast PHM7 and TM63A_HUMAN TRANSMEMBRANE PROTEIN 63A, SwissProt:O94886. This domain usually precedes the 7TM region, pfam02714, and follows a RSN1_TM, pfam13967. Fold recognition programs consistently and with high significance predict this domain to be distantly homologous to RNA binding proteins from the RRM clan.


Pssm-ID: 464272  Cd Length: 164  Bit Score: 173.66  E-value: 3.13e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733  228 RTLFITGLPRDAR-KETVESHFRDAYPTCEVVDVQLCYNVAKLIYLCKEKKKTEKSLTYYTNLQVKTGQRtlINPKPCGQ 306
Cdd:pfam14703   2 RTVLVTGIPKDLRsEEKLRSFFEELYPGTVVERVQIVRDVKKLPKLVEEREKAVRKLEAALAKYLKNGKK--PKKRPTHK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733  307 FCCCEVLGcEWEDAISYYTRMKDRLLERITEEERHVQDQPLGMAFVTFQEKSMATYILKdfnackcqslqckgepqpSSH 386
Cdd:pfam14703  80 LGFLGLFG-KKVDAIDYYTEKLEELEEEIEEEREKVDKKPLGAAFVTFKSERSAAAAAA------------------QIN 140
                         170       180
                  ....*....|....*....|....
gi 270288733  387 SRELYTSKWTVTFAADPEDICWKN 410
Cdd:pfam14703 141 PQLMHPKGWTVELAPEPRDVIWEN 164
COG5594 COG5594
Uncharacterized integral membrane protein [Function unknown];
49-654 1.02e-28

Uncharacterized integral membrane protein [Function unknown];


Pssm-ID: 227881 [Multi-domain]  Cd Length: 827  Bit Score: 123.30  E-value: 1.02e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733  49 GIPTVLLIDVSCFLFLILVFSIIRRRF-WDYgrialvsEADSESRFQRLSSTSSSGQQDFEnelgccpWLTAIFRLHDDQ 127
Cdd:COG5594   23 AVITQLVFAGLIFLVFLILFLILRKRWkRLY-------APRTNFDGQNECLPEPNPSSYWG-------WLEPLVKIPDEF 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733 128 ILEWCGEDAIHYLSFQRHIIFLLVVVSFLSLCVILPVN---LSGDLLDKDPYS-FGRTTIANLQTDNDLlWLHtIFAVIY 203
Cdd:COG5594   89 LLQYAGLDGYFFLRFLKMLIKLLFILSLILIPILLPVNyhfQKATNGNSDSESgLDKLSISNVSPSNRL-YAH-VFLSWF 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733 204 LFLTVGF-----------MRHHT-------QSIKYKEENLVRRTLFITGLPRDARKETVESHFRDAYPTCEVVDVQLCYN 265
Cdd:COG5594  167 FFGYVLFiifrelrfyvvLRQAYlrsplyqQSLLTLQNNLSSRTVLISGLPSELRSDEELKELFDKLKVGEIDSDVLCRD 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733 266 VAKLIYLCKEK----KKTEKSLTYYTNLQVK-TGQRTLINPKPCGQFCCCEV-----------------------LGCEW 317
Cdd:COG5594  247 LGTLQELYKERdkilKKLEKALNELLNKLLKkSHLKTNKKSGKLTPSRKKEFeilpeyvpdkkrpkhrikklnkgIFGKK 326
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733 318 EDAISYYTRMKDRLLERITE-EERHVQDQPLGMAFVTFqeKSMATYilkdfNACKcqslqckgepQPSSHSRELYTSKwt 396
Cdd:COG5594  327 VDAIDYYSAKLTKLDAEIENaRKSLYENTPTKSGFITF--KSQASA-----QIAA----------QSQIYSRVLGKLK-- 387
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733 397 VTFAADPEDICWKNLSIQglRWW--LQWLGINFTLFLGLFFLTTPSIILSTMDKFN-VTKPIHALN---------NPIIS 464
Cdd:COG5594  388 VEIAPAPNDIIWDNLRLS--RKErlFKRISANILFILLIILWAFPVAFVGTISNLNtLSSLWPFLKfilkdppflAGILT 465
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733 465 QFFPTLLLWSFSALLPSIVYYSTLLESHWTKSGENQIMMTKVYIFL---IFMVLILPSLGLTSLDfffRWLFDKTSSEAS 541
Cdd:COG5594  466 GLLPTVALSLLMSIVPYFIRWLSYMQGLVSYSEEEIYVQNKYFAFLfvnLFLVVTLASSFSSIVW---SLLKEPTSIMTL 542
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733 542 IRLEcvfLPDQGAFFVNYVIASAFIGNGMELLRLPGLILYTFRM-IMAKTAADRRNvKQNQAFQYEFGAMYAWMLCVFTV 620
Cdd:COG5594  543 LANN---LPKASNFFISYIILQGLSGFPGTLLQIVPLLLSLVLGkFKDSTPRQKWN-RLETPPSFQFGTVLPQPILLFTI 618
                        650       660       670
                 ....*....|....*....|....*....|....
gi 270288733 621 IVAYSITCPIIAPFGLIYILLKHMVDRHNLYFVY 654
Cdd:COG5594  619 TICYSIISPLILLFGAVYFILNYLAYKYNLIYVS 652
RSN1_TM pfam13967
Late exocytosis, associated with Golgi transport; This family represents the first three ...
52-210 1.81e-14

Late exocytosis, associated with Golgi transport; This family represents the first three transmembrane regions of 11-TM proteins involved in vesicle transport. In S. cerevisiae these proteins are members of the yeast facilitator superfamily and are integral membrane proteins localized to the cell periphery, in particular to the bud-neck region. The distribution is consistent with a role in late exocytosis which is in agreement with the proteins' ability to substitute for the function of Sro7p, required for the sorting of the protein Enap1 into Golgi-derived vesicles destined for the cell surface.


Pssm-ID: 433613  Cd Length: 158  Bit Score: 71.45  E-value: 1.81e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733   52 TVLLIDVSCFLFLILVFSIIRRRFWD--YGRIALVSEadsESRFQRLSSTSSSGqqdfenelgccpWLTAIFRLHDDQIL 129
Cdd:pfam13967   4 TSLVINLVIALVFLLLFSILRPKNKRvyAPRTYLAPE---EERTPPLPGTGLFG------------WIPPLLKIPDEEIL 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 270288733  130 EWCGEDAIHYLSFQRHIIFLLVVVSFLSLCVILPVNLSGDLLDKDPYSFGRT-----TIANLQTDNDLLWLHTIFAVIYL 204
Cdd:pfam13967  69 QHAGLDAYVFLRFLKMLIKIFLVGCLIGWPILLPVNATGGNGEDDGDSLTRTgldklSSSNNVEGSNRLWAHVVVAYIFT 148

                  ....*.
gi 270288733  205 FLTVGF 210
Cdd:pfam13967 149 GFVLYL 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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