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Conserved domains on  [gi|29469071|ref|NP_055530|]
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rho GTPase-activating protein 32 isoform 2 [Homo sapiens]

Protein Classification

Rho GTPase-activating protein( domain architecture ID 10138166)

Rho GTPase-activating protein for Rho/Rac/Cdc42-like small GTPases that act as molecular switches, active in their GTP-bound form but inactive when bound to GDP

CATH:  1.10.555.10
Gene Ontology:  GO:0007165|GO:0005096
PubMed:  17222083|12480336
SCOP:  4001255

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 19-213 1.49e-128

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 399.18  E-value: 1.49e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   19 RVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCK 98
Cdd:cd04384    1 RVFGCDLTEHLLNSGQDVPQVLKSCTEFIEKHGIVDGIYRLSGIASNIQRLRHEFDSEQIPDLTKDVYIQDIHSVSSLCK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   99 LYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAP 178
Cdd:cd04384   81 LYFRELPNPLLTYQLYEKFSEAVSAASDEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKNLAIVWAP 160

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 29469071  179 NLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNH 213
Cdd:cd04384  161 NLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNH 195
 
Name Accession Description Interval E-value
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 19-213 1.49e-128

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 399.18  E-value: 1.49e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   19 RVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCK 98
Cdd:cd04384    1 RVFGCDLTEHLLNSGQDVPQVLKSCTEFIEKHGIVDGIYRLSGIASNIQRLRHEFDSEQIPDLTKDVYIQDIHSVSSLCK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   99 LYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAP 178
Cdd:cd04384   81 LYFRELPNPLLTYQLYEKFSEAVSAASDEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKNLAIVWAP 160

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 29469071  179 NLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNH 213
Cdd:cd04384  161 NLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNH 195
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 37-185 2.21e-57

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 195.07  E-value: 2.21e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071     37 PQVLQSCTAFIERYGI-VDGIYRLSGVASNIQRLRHEFDSEHVPDLtkEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYE 115
Cdd:pfam00620    1 PLIVRKCVEYLEKRGLdTEGIFRVSGSASRIKELREAFDRGPDVDL--DLEEEDVHVVASLLKLFLRELPEPLLTFELYE 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071    116 KFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQ 185
Cdd:pfam00620   79 EFIEAAKLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 35-214 3.73e-56

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 192.87  E-value: 3.73e-56
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071      35 EVPQVLQSCTAFIERYGI-VDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYvqDIHSVGSLCKLYFRELPNPLLTYQL 113
Cdd:smart00324    2 PIPIIVEKCIEYLEKRGLdTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLSEY--DVHDVAGLLKLFLRELPEPLITYEL 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071     114 YEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESacfsg 193
Cdd:smart00324   80 YEEFIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGEV----- 154

                           170       180
                    ....*....|....*....|.
gi 29469071     194 tAAFMEVRIQSVVVEFILNHV 214
Cdd:smart00324  155 -ASLKDIRHQNTVIEFLIENA 174
 
Name Accession Description Interval E-value
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 19-213 1.49e-128

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 399.18  E-value: 1.49e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   19 RVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCK 98
Cdd:cd04384    1 RVFGCDLTEHLLNSGQDVPQVLKSCTEFIEKHGIVDGIYRLSGIASNIQRLRHEFDSEQIPDLTKDVYIQDIHSVSSLCK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   99 LYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAP 178
Cdd:cd04384   81 LYFRELPNPLLTYQLYEKFSEAVSAASDEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKNLAIVWAP 160

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 29469071  179 NLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNH 213
Cdd:cd04384  161 NLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNH 195
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 37-185 2.21e-57

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 195.07  E-value: 2.21e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071     37 PQVLQSCTAFIERYGI-VDGIYRLSGVASNIQRLRHEFDSEHVPDLtkEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYE 115
Cdd:pfam00620    1 PLIVRKCVEYLEKRGLdTEGIFRVSGSASRIKELREAFDRGPDVDL--DLEEEDVHVVASLLKLFLRELPEPLLTFELYE 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071    116 KFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQ 185
Cdd:pfam00620   79 EFIEAAKLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 35-214 3.73e-56

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 192.87  E-value: 3.73e-56
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071      35 EVPQVLQSCTAFIERYGI-VDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYvqDIHSVGSLCKLYFRELPNPLLTYQL 113
Cdd:smart00324    2 PIPIIVEKCIEYLEKRGLdTEGIYRVSGSKSRVKELRDAFDSGPDPDLDLSEY--DVHDVAGLLKLFLRELPEPLITYEL 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071     114 YEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESacfsg 193
Cdd:smart00324   80 YEEFIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGEV----- 154

                           170       180
                    ....*....|....*....|.
gi 29469071     194 tAAFMEVRIQSVVVEFILNHV 214
Cdd:smart00324  155 -ASLKDIRHQNTVIEFLIENA 174
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 37-213 6.79e-52

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 180.19  E-value: 6.79e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   37 PQVLQSCTAFIERYGI-VDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEpyvQDIHSVGSLCKLYFRELPNPLLTYQLYE 115
Cdd:cd00159    1 PLIIEKCIEYLEKNGLnTEGIFRVSGSASKIEELKKKFDRGEDIDDLED---YDVHDVASLLKLYLRELPEPLIPFELYD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071  116 KFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQiesacfSGTA 195
Cdd:cd00159   78 EFIELAKIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLLRPPD------SDDE 151

                        170
                 ....*....|....*...
gi 29469071  196 AFMEVRIQSVVVEFILNH 213
Cdd:cd00159  152 LLEDIKKLNEIVEFLIEN 169
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 21-218 9.70e-44

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 157.95  E-value: 9.70e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   21 FGCDLGEHLLNSGFEVPQVLQSCTAFIERYGI-VDGIYRLSGVASNIQRLRHEFDSE--HVPDLTKEPYVQDIHSVGSLC 97
Cdd:cd04398    1 FGVPLEDLILREGDNVPNIVYQCIQAIENFGLnLEGIYRLSGNVSRVNKLKELFDKDplNVLLISPEDYESDIHSVASLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   98 KLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWA 177
Cdd:cd04398   81 KLFFRELPEPLLTKALSREFIEAAKIEDESRRRDALHGLINDLPDANYATLRALMFHLARIKEHESVNRMSVNNLAIIWG 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 29469071  178 PNLLRSKqiesacfSGTAAfmEVRIQSVVVEFILNHVDVLF 218
Cdd:cd04398  161 PTLMNAA-------PDNAA--DMSFQSRVIETLLDNAYQIF 192
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 19-220 5.05e-42

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 153.38  E-value: 5.05e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   19 RVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVD-GIYRLSGVASNIQRLRHEFDSEHVpDLTKEPYVQDIHSVGSLC 97
Cdd:cd04386    3 PVFGTPLEEHLKRTGREIALPIEACVMCLLETGMNEeGLFRVGGGASKLKRLKAALDAGTF-SLPLDEFYSDPHAVASAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   98 KLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWA 177
Cdd:cd04386   82 KSYLRELPDPLLTYNLYEDWVQAANKPDEDERLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDENKMSPSNIAIVLA 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 29469071  178 PNLLRSKqIESACFSGTAAfMEVRIqSVVVEFILNHVDVLFSG 220
Cdd:cd04386  162 PNLLWAK-NEGSLAEMAAG-TSVHV-VAIVELIISHADWFFPG 201
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 21-218 2.12e-36

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 136.88  E-value: 2.12e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   21 FGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIV-DGIYRLSGVASNIQRLRHEFDSE-HVPDLTKEPYvQDIHSVGSLCK 98
Cdd:cd04372    1 YGCDLTTLVKAHNTQRPMVVDMCIREIEARGLQsEGLYRVSGFAEEIEDVKMAFDRDgEKADISATVY-PDINVITGALK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   99 LYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAP 178
Cdd:cd04372   80 LYFRDLPIPVITYDTYPKFIDAAKISNPDERLEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKDNKMNAENLGIVFGP 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 29469071  179 NLLRSKQIesacfSGTAAFMEVRIQSVVVEFILNHVDVLF 218
Cdd:cd04372  160 TLMRPPED-----SALTTLNDMRYQILIVQLLITNEDVLF 194
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 21-211 2.14e-36

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 136.75  E-value: 2.14e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   21 FGCDLGEHLLNSGFEVPQVLQSCTAFIERYGI-VDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYvQDIHSVGSLCKL 99
Cdd:cd04403    1 FGCHLEALCQRENSTVPKFVRLCIEAVEKRGLdVDGIYRVSGNLAVIQKLRFAVDHDEKLDLDDSKW-EDIHVITGALKL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071  100 YFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPN 179
Cdd:cd04403   80 FFRELPEPLFPYSLFNDFVAAIKLSDYEQRVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEKNRMTTQNLAIVFGPT 159

                        170       180       190
                 ....*....|....*....|....*....|..
gi 29469071  180 LLRSKQiesacFSGTAAFMEVrIQSVVVEFIL 211
Cdd:cd04403  160 LLRPEQ-----ETGNIAVHMV-YQNQIVELIL 185
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 36-218 7.28e-35

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 132.52  E-value: 7.28e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   36 VPQVLQSCTAFIERYGI-VDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLY 114
Cdd:cd04395   18 VPLIVEVCCNIVEARGLeTVGIYRVPGNNAAISALQEELNRGGFDIDLQDPRWRDVNVVSSLLKSFFRKLPEPLFTNELY 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071  115 EKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIesacfSGT 194
Cdd:cd04395   98 PDFIEANRIEDPVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEVNKMEPRNLAIVFGPTLVRTSDD-----NME 172

                        170       180
                 ....*....|....*....|....
gi 29469071  195 AAFMEVRIQSVVVEFILNHVDVLF 218
Cdd:cd04395  173 TMVTHMPDQCKIVETLIQHYDWFF 196
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 21-182 5.71e-31

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 121.01  E-value: 5.71e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   21 FGCDLGEhLLNSGFEVPQVLQSCTAFIERYGI-VDGIYRLSGVASNIQRLRHEFDSEhvPDLTK-EPYvqDIHSVGSLCK 98
Cdd:cd04377    1 FGVSLSS-LTSEDRSVPLVLEKLLEHIEMHGLyTEGIYRKSGSANKIKELRQGLDTD--PDSVNlEDY--PIHVITSVLK 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   99 LYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAP 178
Cdd:cd04377   76 QWLRELPEPLMTFELYENFLRAMELEEKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALQEEVNRMSANALAIVFAP 155


                 ....
gi 29469071  179 NLLR 182
Cdd:cd04377  156 CILR 159
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 21-213 2.10e-30

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 119.83  E-value: 2.10e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   21 FGCDLGEHLLNSGFEVPQVLQSCTAFIE-RYGIVDGIYRLSGVASNIQRLRHEFD--------SEHVPdltkepyvqdiH 91
Cdd:cd04378    1 FGVDFSQVPRDFPDEVPFIIKKCTSEIEnRALGVQGIYRVSGSKARVEKLCQAFEngkdlvelSELSP-----------H 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   92 SVGSLCKLYFRELPNPLLTYQLYEKFSD-------------AVSAATDEERLI-KIHDVIQQLPPPHYRTLEFLMRHLSL 157
Cdd:cd04378   70 DISSVLKLFLRQLPEPLILFRLYNDFIAlakeiqrdteedkAPNTPIEVNRIIrKLKDLLRQLPASNYNTLQHLIAHLYR 149

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 29469071  158 LADYCSITNMHAKNLAIVWAPNLLRSKQIESACfsGTAAFMEVRIQSVVVEFILNH 213
Cdd:cd04378  150 VAEQFEENKMSPNNLGIVFGPTLIRPRPGDADV--SLSSLVDYGYQARLVEFLITN 203
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 36-213 3.14e-28

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 113.48  E-value: 3.14e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   36 VPQVLQSCTAFIERYGIVD-GIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVqDIHSVGSLCKLYFRELPNPLLTYQLY 114
Cdd:cd04387   16 VPYIVRQCVEEVERRGMEEvGIYRISGVATDIQALKAAFDTNNKDVSVMLSEM-DVNAIAGTLKLYFRELPEPLFTDELY 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071  115 EKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGT 194
Cdd:cd04387   95 PNFAEGIALSDPVAKESCMLNLLLSLPDPNLVTFLFLLHHLKRVAEREEVNKMSLHNLATVFGPTLLRPSEKESKIPTNT 174

                        170       180
                 ....*....|....*....|..
gi 29469071  195 AAF---MEVRIQSVVVEFILNH 213
Cdd:cd04387  175 MTDswsLEVMSQVQVLLYFLQL 196
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 26-213 4.01e-28

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 113.26  E-value: 4.01e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   26 GEHLLNS-GFevpQVLQSCTAFIERYGIVD-GIYRLSGVASNIQRLRHE-FDSEHVP--DLTKEPYVQDIHSVGSLCKLY 100
Cdd:cd04374   20 GEAQLDDiGF---KFVRKCIEAVETRGINEqGLYRVVGVNSKVQKLLSLgLDPKTSTpgDVDLDNSEWEIKTITSALKTY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071  101 FRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNL 180
Cdd:cd04374   97 LRNLPEPLMTYELHNDFINAAKSENLESRVNAIHSLVHKLPEKNREMLELLIKHLTNVSDHSKKNLMTVSNLGVVFGPTL 176

                        170       180       190
                 ....*....|....*....|....*....|...
gi 29469071  181 LRSKQiESacfsgTAAFMEVRIQSVVVEFILNH 213
Cdd:cd04374  177 LRPQE-ET-----VAAIMDIKFQNIVVEILIEN 203
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 35-218 1.24e-27

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 112.15  E-value: 1.24e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   35 EVPQVLQSCTAFIERYGI-VDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEpyvQDIHSVGSLCKLYFRELPNPLLTYQL 113
Cdd:cd04376    8 QVPRLVESCCQHLEKHGLqTVGIFRVGSSKKRVRQLREEFDRGIDVVLDEN---HSVHDVAALLKEFFRDMPDPLLPREL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071  114 YEKFSDAVSAATDeERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSIT-----------NMHAKNLAIVWAPNLLR 182
Cdd:cd04376   85 YTAFIGTALLEPD-EQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSidedgqevsgnKMTSLNLATIFGPNLLH 163

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 29469071  183 SKQIESACFSGTAAFMEVRIQSV-VVEFILNHVDVLF 218
Cdd:cd04376  164 KQKSGEREFVQASLRIEESTAIInVVQTMIDNYEELF 200
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 26-189 9.34e-27

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 108.93  E-value: 9.34e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   26 GEHLLN---SGFEVPQVLQSCTAFIERYGI-VDGIYRLSGVASNIQRLRHEF--DSEHVpDLTKEPYvqDIHSVGSLCKL 99
Cdd:cd04385    2 GPALEDqqlTDNDIPVIVDKCIDFITQHGLmSEGIYRKNGKNSSVKKLLEAFrkDARSV-QLREGEY--TVHDVADVLKR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071  100 YFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPN 179
Cdd:cd04385   79 FLRDLPDPLLTSELHAEWIEAAELENKDERIARYKELIRRLPPINRATLKVLIGHLYRVQKHSDENQMSVHNLALVFGPT 158

                        170
                 ....*....|
gi 29469071  180 LLRSKQIESA 189
Cdd:cd04385  159 LFQTDEHSVG 168
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 20-180 1.16e-26

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 108.60  E-value: 1.16e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   20 VFGCDLGEHL-LNS----GFEVPQVLQSCTAFIERYGIV--DGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHS 92
Cdd:cd04400    1 IFGSPLEEAVeLSShkynGRDLPSVVYRCIEYLDKNRAIyeEGIFRLSGSASVIKQLKERFNTEYDVDLFSSSLYPDVHT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   93 VGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDE-ERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKN 171
Cdd:cd04400   81 VAGLLKLYLRELPTLILGGELHNDFKRLVEENHDRsQRALELKDLVSQLPQANYDLLYVLFSFLRKIIEHSDVNKMNLRN 160


                 ....*....
gi 29469071  172 LAIVWAPNL 180
Cdd:cd04400  161 VCIVFSPTL 169
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 21-213 3.35e-25

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 105.27  E-value: 3.35e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   21 FGCDLGEHLLNSGFEVPQVLQSCTAFIE-RYGIVDGIYRLSGVASNIQRLRHEFDS-EHVPDLTkEPYVQDIHSVgslCK 98
Cdd:cd04409    1 FGADFAQVAKKSPDGIPFIIKKCTSEIEsRALCLKGIYRVNGAKSRVEKLCQAFENgKDLVELS-ELSPHDISNV---LK 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   99 LYFRELPNPLLTYQLYEKF------------SDAVSAATDEER----------LIKIHDVIQQLPPPHYRTLEFLMRHLS 156
Cdd:cd04409   77 LYLRQLPEPLILFRLYNEFiglakesqhvneTQEAKKNSDKKWpnmctelnriLLKSKDLLRQLPAPNYNTLQFLIVHLH 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 29469071  157 LLADYCSITNMHAKNLAIVWAPNLLRSKQIESACfsGTAAFMEVRIQSVVVEFILNH 213
Cdd:cd04409  157 RVSEQAEENKMSASNLGIIFGPTLIRPRPTDATV--SLSSLVDYPHQARLVELLITY 211
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 35-212 1.04e-24

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 102.92  E-value: 1.04e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   35 EVPQVLQSCTAFIERYGI-VDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVqdIHSVGSLCKLYFRELPNPLLTYQL 113
Cdd:cd04373   14 PIPIFLEKCVEFIEATGLeTEGIYRVSGNKTHLDSLQKQFDQDHNLDLVSKDFT--VNAVAGALKSFFSELPDPLIPYSM 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071  114 YEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSG 193
Cdd:cd04373   92 HLELVEAAKINDREQRLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKVNLMTSENLSICFWPTLMRPDFTSMEALSA 171

                        170
                 ....*....|....*....
gi 29469071  194 TAAFmevriQSVVVEFILN 212
Cdd:cd04373  172 TRIY-----QTIIETFIQQ 185
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 19-180 2.81e-24

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 101.77  E-value: 2.81e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   19 RVFGCDLGEhLLNSGF---EVPQVLQSCTAFIERYGIV-DGIYRLSGVASNIQRLRHEFDS-EHVpDLTKEpyvQDIHSV 93
Cdd:cd04393    1 KVFGVPLQE-LQQAGQpenGVPAVVRHIVEYLEQHGLEqEGLFRVNGNAETVEWLRQRLDSgEEV-DLSKE---ADVCSA 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   94 GSLCKLYFRELPNPLLT-------YQLYEKFSDavsaatDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITN 166
Cdd:cd04393   76 ASLLRLFLQELPEGLIPaslqirlMQLYQDYNG------EDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHENR 149

                        170
                 ....*....|....
gi 29469071  167 MHAKNLAIVWAPNL 180
Cdd:cd04393  150 MTAENLAAVFGPDV 163
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 15-213 9.27e-24

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 100.60  E-value: 9.27e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   15 ILKERVFGCDLgehllnsgfeVPQVLQSCTAFIERYGIVD-GIYRLSGVASNIQRLRHEFDSEHVPDLTKEpyvQDIHSV 93
Cdd:cd04390   11 VAYERKFGPRL----------VPILVEQCVDFIREHGLKEeGLFRLPGQANLVKQLQDAFDAGERPSFDSD---TDVHTV 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   94 GSLCKLYFRELPNPLLTYQLYEKF--SDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKN 171
Cdd:cd04390   78 ASLLKLYLRELPEPVIPWAQYEDFlsCAQLLSKDEEKGLGELMKQVSILPKVNYNLLSYICRFLDEVQSNSSVNKMSVQN 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 29469071  172 LAIVWAPNLLRSKqIESAcfsgtAAFME--VRIQSVVVEFILNH 213
Cdd:cd04390  158 LATVFGPNILRPK-VEDP-----ATIMEgtPQIQQLMTVMISKH 195
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 21-218 1.07e-23

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 100.49  E-value: 1.07e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   21 FGCDLgEHLLNSGFE---VPQVLQSCTAFIERYGI-VDGIYRLSGVASNIQRLRHEFDSEHVPDLTKepyVQDIHSVGSL 96
Cdd:cd04404    6 FGVSL-QFLKEKNPEqepIPPVVRETVEYLQAHALtTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQ---YEDVHLPAVI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   97 CKLYFRELPNPLLTYQLYEKFSdAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVW 176
Cdd:cd04404   82 LKTFLRELPEPLLTFDLYDDIV-GFLNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAVVF 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 29469071  177 APNLLRSKqiesacfSGTAAFMEVRIQSVVVEFILNHVDVLF 218
Cdd:cd04404  161 GPNLLWAK-------DASMSLSAINPINTFTKFLLDHQDEIF 195
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 19-182 1.25e-23

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 100.19  E-value: 1.25e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   19 RVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIV-DGIYRLSGVASNIQRLRHEFDSEHVPdLTKEPYVQDIHSVGSLC 97
Cdd:cd04383    1 KLFNGSLEEYIQDSGQAIPLVVESCIRFINLYGLQhQGIFRVSGSQVEVNDIKNAFERGEDP-LADDQNDHDINSVAGVL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   98 KLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWA 177
Cdd:cd04383   80 KLYFRGLENPLFPKERFEDLMSCVKLENPTERVHQIREILSTLPRSVIIVMRYLFAFLNHLSQFSDENMMDPYNLAICFG 159


                 ....*
gi 29469071  178 PNLLR 182
Cdd:cd04383  160 PTLMP 164
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 21-182 1.80e-22

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 96.60  E-value: 1.80e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   21 FGCDLGEhLLNSGFEVPQVLQSCTAFIERYGI-VDGIYRLSGVASNIQRLRHEFDSEhvPDLTK-EPYvqDIHSVGSLCK 98
Cdd:cd04407    1 FGVRVGS-LTSNKTSVPIVLEKLLEHVEMHGLyTEGIYRKSGSANRMKELHQLLQAD--PENVKlENY--PIHAITGLLK 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   99 LYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAP 178
Cdd:cd04407   76 QWLRELPEPLMTFAQYNDFLRAVELPEKQEQLQAIYRVLEQLPTANHNTLERLIFHLVKVALEEDVNRMSPNALAIVFAP 155


                 ....
gi 29469071  179 NLLR 182
Cdd:cd04407  156 CLLR 159
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 33-191 8.15e-22

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 94.42  E-value: 8.15e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   33 GFEVPQVLQSCTAFIERYGI-VDGIYRLSGVASNIQRLRHEFDSEHVPDLtkEPYvqDIHSVGSLCKLYFRELPNPLLTY 111
Cdd:cd04381   17 GIDLPLVFRECIDYVEKHGMkCEGIYKVSGIKSKVDELKAAYNRRESPNL--EEY--EPPTVASLLKQYLRELPEPLLTK 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071  112 QLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACF 191
Cdd:cd04381   93 ELMPRFEEACGRPTEAEREQELQRLLKELPECNRLLLAWLIVHMDHVIAQELETKMNIQNISIVLSPTVQISNRLLYALL 172
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 36-212 1.02e-21

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 94.67  E-value: 1.02e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   36 VPQVLQSCTAFIERYGIVD-GIYRLSGVASNIQRLRHEF-DSEHVPDLTKepyvQDIHSVGSLCKLYFRELPNPLLTYQL 113
Cdd:cd04382   17 IPALIVHCVNEIEARGLTEeGLYRVSGSEREVKALKEKFlRGKTVPNLSK----VDIHVICGCLKDFLRSLKEPLITFAL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071  114 YEKFSDAVSAAtDEERLIK-IHDVIQQLPPPHYRTLEFLMRHLSLLADyCSITNMHAKNLAIVWAPNLLRSKQIESacfS 192
Cdd:cd04382   93 WKEFMEAAEIL-DEDNSRAaLYQAISELPQPNRDTLAFLILHLQRVAQ-SPECKMDINNLARVFGPTIVGYSVPNP---D 167

                        170       180
                 ....*....|....*....|
gi 29469071  193 GTAAFMEVRIQSVVVEFILN 212
Cdd:cd04382  168 PMTILQDTVRQPRVVERLLE 187
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 35-213 2.15e-21

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 94.11  E-value: 2.15e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   35 EVPQVLQSCTAFIERYGI-VDGIYRLSGVASNIQRLRHEFD--------SEHVPdltkepyvqdiHSVGSLCKLYFRELP 105
Cdd:cd04408   15 EVPFVVVRCTAEIENRALgVQGIYRISGSKARVEKLCQAFEngrdlvdlSGHSP-----------HDITSVLKHFLKELP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071  106 NPLLTYQLYEKF------------SDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLA 173
Cdd:cd04408   84 EPVLPFQLYDDFialakelqrdseKAAESPSIVENIIRSLKELLGRLPVSNYNTLRHLMAHLYRVAERFEDNKMSPNNLG 163

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 29469071  174 IVWAPNLLR---SKQIESACfsgtaaFMEVRIQSVVVEFILNH 213
Cdd:cd04408  164 IVFGPTLLRplvGGDVSMIC------LLDTGYQAQLVEFLISN 200
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 36-218 2.42e-21

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 93.52  E-value: 2.42e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   36 VPQVLQSCTAFIERYG-IVDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPyvqdIHSVGSLCKLYFRELPNPLLTYQLY 114
Cdd:cd04402   15 LPKPILDMLSLLYQKGpSTEGIFRRSANAKACKELKEKLNSGVEVDLKAEP----VLLLASVLKDFLRNIPGSLLSSDLY 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071  115 EKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSkqieSACFSGT 194
Cdd:cd04402   91 EEWMSALDQENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAVCIAPSLLWP----PASSELQ 166

                        170       180
                 ....*....|....*....|....
gi 29469071  195 AAFMEVriQSVVVEFILNHVDVLF 218
Cdd:cd04402  167 NEDLKK--VTSLVQFLIENCQEIF 188
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 21-182 5.88e-21

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 92.37  E-value: 5.88e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   21 FGCDLGEhLLNSGFEVPQVLQSCTAFIERYGI-VDGIYRLSGVASNIQRLRHEFDSEhVPDLTKEPYvqDIHSVGSLCKL 99
Cdd:cd04406    1 FGVELSR-LTSEDRSVPLVVEKLINYIEMHGLyTEGIYRKSGSTNKIKELRQGLDTD-ANSVNLDDY--NIHVIASVFKQ 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071  100 YFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPN 179
Cdd:cd04406   77 WLRDLPNPLMTFELYEEFLRAMGLQERRETVRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEETNRMSANALAIVFAPC 156


                 ...
gi 29469071  180 LLR 182
Cdd:cd04406  157 ILR 159
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 36-185 5.24e-20

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 90.22  E-value: 5.24e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   36 VPQVLQSCTAFIERYGI-VDGIYRLSGVASNIQRLRHEFDSEHVP-DLTKEPYvQDIHSVGSLCKLYFRELPNPLLTYQL 113
Cdd:cd04379   18 VPIVLQKCVQEIERRGLdVIGLYRLCGSAAKKKELRDAFERNSAAvELSEELY-PDINVITGVLKDYLRELPEPLITPQL 96

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 29469071  114 YEKFSDAVSAATDEERLIKIHD---VIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQ 185
Cdd:cd04379   97 YEMVLEALAVALPNDVQTNTHLtlsIIDCLPLSAKATLLLLLDHLSLVLSNSERNKMTPQNLAVCFGPVLMFCSQ 171
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 53-184 4.65e-19

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 87.42  E-value: 4.65e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   53 VDGIYRLSGvasNIQRLR---HEFDSE--HVPDLTKEPYVQdihsVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDE 127
Cdd:cd04397   45 VEGVFRKNG---NIRRLKeltEEIDKNptEVPDLSKENPVQ----LAALLKKFLRELPDPLLTFKLYRLWISSQKIEDEE 117

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 29469071  128 ERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITN-----MHAKNLAIVWAPNLLRSK 184
Cdd:cd04397  118 ERKRVLHLVYCLLPKYHRDTMEVLFSFLKWVSSFSHIDEetgskMDIHNLATVITPNILYSK 179
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 20-218 5.82e-18

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 84.32  E-value: 5.82e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   20 VFGCDLGEHLLNS-----GFEVPQVLQSCTAFIERYGI-VDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQdIHSV 93
Cdd:cd04391    1 LFGVPLSTLLERDqkkvpGSKVPLIFQKLINKLEERGLeTEGILRIPGSAQRVKFLCQELEAKFYEGTFLWDQVK-QHDA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   94 GSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLA 173
Cdd:cd04391   80 ASLLKLFIRELPQPLLTVEYLPAFYSVQGLPSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKNKMNLWNVA 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 29469071  174 IVWAPNLLRSKQIESACFSGTAAFMEVRIQ-SVVVEFILNHVDVLF 218
Cdd:cd04391  160 MIMAPNLFPPRGKHSKDNESLQEEVNMAAGcANIMRLLIRYQDLLW 205
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 20-180 7.14e-17

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 81.31  E-value: 7.14e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   20 VFGCDLGEHLLNSGFEVPQVLQSCTAFIeRYGIVD--GIYRLSGVASNIQRLRHEFDSEHVPDLTKEpyvQDIHSVGSLC 97
Cdd:cd04375    4 VFGVPLLVNLQRTGQPLPRSIQQAMRWL-RNNALDqvGLFRKSGVKSRIQKLRSMIESSTDNVNYDG---QQAYDVADML 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   98 KLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWA 177
Cdd:cd04375   80 KQYFRDLPEPLLTNKLSETFIAIFQYVPKEQRLEAVQCAILLLPDENREVLQTLLYFLSDVAANSQENQMTATNLAVCLA 159


                 ...
gi 29469071  178 PNL 180
Cdd:cd04375  160 PSL 162
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 20-208 1.25e-16

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 80.21  E-value: 1.25e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   20 VFGCDL----GEHLLNSGfEVPQVLQSCTAFIERYGIVDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYvqdihSVGS 95
Cdd:cd04394    1 VFGVPLhslpHSTVPEYG-NVPKFLVDACTFLLDHLSTEGLFRKSGSVVRQKELKAKLEGGEACLSSALPC-----DVAG 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   96 LCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIV 175
Cdd:cd04394   75 LLKQFFRELPEPLLPYDLHEALLKAQELPTDEERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCSENKMDSSNLAVI 154

                        170       180       190
                 ....*....|....*....|....*....|...
gi 29469071  176 WAPNLLRSKQIESACFSGTAafMEVRIQSVVVE 208
Cdd:cd04394  155 FAPNLFQSEEGGEKMSSSTE--KRLRLQAAVVQ 185
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 54-182 1.22e-15

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 77.05  E-value: 1.22e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   54 DGIYRLSGVASNIQRLRHEFDSEHVPDLTKEpyvqDIHSVGSLCKLYFRELPNPLLTYQLYEkfsDAVSAATDEERLIKI 133
Cdd:cd04389   41 EGIFRVPGDIDEVNELKLRVDQWDYPLSGLE----DPHVPASLLKLWLRELEEPLIPDALYQ---QCISASEDPDKAVEI 113

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 29469071  134 hdvIQQLPPPHYRTLEFLMRHLSLLA--DYCSITNMHAKNLAIVWAPNLLR 182
Cdd:cd04389  114 ---VQKLPIINRLVLCYLINFLQVFAqpENVAHTKMDVSNLAMVFAPNILR 161
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 36-217 1.31e-12

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 68.98  E-value: 1.31e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   36 VPQVLQSCTAFIERYGI-VDGIYRLSGVASNIQRLRHEFDSEhvPDLTK----EPYvqDIHSVGSLCKLYFRELPNPLLT 110
Cdd:cd04396   32 IPVVVAKCGVYLKENATeVEGIFRVAGSSKRIRELQLIFSTP--PDYGKsfdwDGY--TVHDAASVLRRYLNNLPEPLVP 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071  111 YQLYEKFSDAVSAATDEERLIKIH-----------------DVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLA 173
Cdd:cd04396  108 LDLYEEFRNPLRKRPRILQYMKGRineplntdidqaikeyrDLITRLPNLNRQLLLYLLDLLAVFARNSDKNLMTASNLA 187

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 29469071  174 IVWAPNLLRSKQIESACfsgtaafMEVRIQSVVVEFILNHVDVL 217
Cdd:cd04396  188 AIFQPGILSHPDHEMDP-------KEYKLSRLVVEFLIEHQDKF 224
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 38-203 1.79e-08

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 56.70  E-value: 1.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   38 QVLQsCTAFIERYGIVDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYvqDIHSVGSLCKLYFRELPNPLLT---YQLY 114
Cdd:cd04392   12 QIYQ-LIEYLEKNLRVEGLFRKPGNSARQQELRDLLNSGTDLDLESGGF--HAHDCATVLKGFLGELPEPLLThahYPAH 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071  115 EKFSD--------AVSAATDEERLIK-IHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQ 185
Cdd:cd04392   89 LQIADlcqfdekgNKTSAPDKERLLEaLQLLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFTPHLICPRN 168

                        170       180
                 ....*....|....*....|....*
gi 29469071  186 I-------ESACFSGTAAFMEVRIQ 203
Cdd:cd04392  169 LtpedlheNAQKLNSIVTFMIKHSQ 193
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 34-212 4.41e-08

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 55.42  E-value: 4.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   34 FEVPQVLQSCTAFIERYGIVD-GIYRLSGVASN----IQRLRHEFDSEHVPDLTKepyvqDIHSVGSlCKLYF-RELPNP 107
Cdd:cd04380   48 LSIPKEIWRLVDYLYTRGLAQeGLFEEPGLPSEpgelLAEIRDALDTGSPFNSPG-----SAESVAE-ALLLFlESLPDP 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071  108 LLTYQLYEKFSDAVsaATDEERLIKIhdVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKqiE 187
Cdd:cd04380  122 IIPYSLYERLLEAV--ANNEEDKRQV--IRISLPPVHRNVFVYLCSFLRELLSESADRGLDENTLATIFGRVLLRDP--P 195

                        170       180
                 ....*....|....*....|....*
gi 29469071  188 SACFSGTAAFMEvRIQSVVVEFILN 212
Cdd:cd04380  196 RAGGKERRAERD-RKRAFIEQFLLN 219
RhoGAP_fRGD2 cd04399
RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 93-219 4.79e-06

RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD2-like proteins. Yeast Rgd2 is a GAP protein for Cdc42 and Rho5. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239864  Cd Length: 212  Bit Score: 49.25  E-value: 4.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   93 VGSLCKLYFRELPNPLLTYQLYEKFSDAVSA------ATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADycsITN 166
Cdd:cd04399   81 VASVLKLYLLELPDSLIPHDIYDLIRSLYSAyppsqeDSDTARIQGLQSTLSQLPKSHIATLDAIITHFYRLIE---ITK 157

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 29469071  167 M------HAKNLAIVWAPNLLRskqiesaCFSGTAAFMEVRIQSVVVEFILNHVDVLFS 219
Cdd:cd04399  158 MgeseeeYADKLATSLSREILR-------PIIESLLTIGDKHGYKFFRDLLTHKDQIFS 209
RhoGAP_p85 cd04388
RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 37-204 2.26e-05

RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) homology (BH) domain. Class IA PI3Ks are heterodimers, containing a regulatory subunit (p85) and a catalytic subunit (p110) and are activated by growth factor receptor tyrosine kinases (RTKs); this activation is mediated by the p85 subunit. p85 isoforms, alpha and beta, contain a C-terminal p110-binding domain flanked by two SH2 domains, an N-terminal SH3 domain, and a RhoGAP domain flanked by two proline-rich regions. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239853  Cd Length: 200  Bit Score: 47.18  E-value: 2.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071   37 PQVLQSCTAFIERYGIVDGIYRLSGVASNIQRLRHEFDSEhVPDLTKEPYvqDIHSVGSLCKLYFRELPNPLLTYQLY-E 115
Cdd:cd04388   16 PPLLIKLVEAIEKKGLESSTLYRTQSSSSLTELRQILDCD-AASVDLEQF--DVAALADALKRYLLDLPNPVIPAPVYsE 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29469071  116 KFSDAVSAATDEERLIKIHDVIQ--QLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSG 193
Cdd:cd04388   93 MISRAQEVQSSDEYAQLLRKLIRspNLPHQYWLTLQYLLKHFFRLCQSSSKNLLSARALAEIFSPLLFRFQPASSDSPEF 172

                        170
                 ....*....|.
gi 29469071  194 TAAFMEVRIQS 204
Cdd:cd04388  173 HIRIIEVLITS 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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