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Conserved domains on  [gi|38202246|ref|NP_055538|]
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syntaphilin isoform 2 [Homo sapiens]

Protein Classification

syntaphilin domain-containing protein( domain architecture ID 10633823)

syntaphilin domain-containing protein similar to Homo sapiens syntaphilin, a syntaxin-1 clamp that controls SNARE assembly, and syntabulin, a microtubule-associated protein implicated in syntaxin transport in neurons

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Syntaphilin pfam15290
Golgi-localized syntaxin-1-binding clamp; Syntaphilin or Syntabulin is a family of eukaryotic ...
 18-329 3.84e-170

Golgi-localized syntaxin-1-binding clamp; Syntaphilin or Syntabulin is a family of eukaryotic proteins. Syntaphilin binds to syntaxin-1 thereby inhibiting SNARE complex formation by absorbing free syntaxin-1. So it is a syntaxin-1 clamp that controls SNARE assembly.


:

Pssm-ID: 464617 [Multi-domain]  Cd Length: 305  Bit Score: 481.54  E-value: 3.84e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38202246    18 RTSPPVSVRDAYGTSSLSSSSNSGSYKGSDSSPTPRRSMKYTLCSDNHGIKPPTPEQYLTPLQQKEVCIRHLKARLKDTQ 97
Cdd:pfam15290   1 NQGSPVNNRDAYGPSSLSSSSNSGSCKGSDSSPTRRRSGRYHSCGDNHGIKPPNPEQYLTPLQQKEVTIRHLKTKLKESE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38202246    98 DRLQDRDTEIDDLKTQLSRMQEDWIEEECHRVEAQLALKEARKEIKQLKQVIDTVKNNLIDKDKGLQKYFVDINIQNKKL 177
Cdd:pfam15290  81 NRLQDRETEIEELKSQLSRMREDWIEEECHRVEAQLALKEARKEIKQLKQVIETMKSSLAEKDKGIQKYFVDINIQNKKL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38202246   178 ETLLHSMEVAQNGMAKEDGTGESAGGSPARSLTRSSTYTKLSDPAVcGDRQPGDPSSGSAEDGADSGFAAADDTLSRTDA 257
Cdd:pfam15290 161 ESLLQSMELAQNGSLRDEGTLEFACDSPAKSLTRSSTYTKLSDQLA-AEENGLELEDQSAEEMADSGLLANDEMANRTDL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38202246   258 LeassllssgvdcgtEETSLHSSFGLGPRFPASNTYEKLL---CGMEAGVQA-----SCMQERAIQTDFVQYQPDLDTIL 329
Cdd:pfam15290 240 L--------------EEVFMSTAVEAGDLAPFSSTYEKLMgsqKSVEALPSCseekqQMVEEQAIQTDVVPYSPDLDTLL 305
 
Name Accession Description Interval E-value
Syntaphilin pfam15290
Golgi-localized syntaxin-1-binding clamp; Syntaphilin or Syntabulin is a family of eukaryotic ...
 18-329 3.84e-170

Golgi-localized syntaxin-1-binding clamp; Syntaphilin or Syntabulin is a family of eukaryotic proteins. Syntaphilin binds to syntaxin-1 thereby inhibiting SNARE complex formation by absorbing free syntaxin-1. So it is a syntaxin-1 clamp that controls SNARE assembly.


Pssm-ID: 464617 [Multi-domain]  Cd Length: 305  Bit Score: 481.54  E-value: 3.84e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38202246    18 RTSPPVSVRDAYGTSSLSSSSNSGSYKGSDSSPTPRRSMKYTLCSDNHGIKPPTPEQYLTPLQQKEVCIRHLKARLKDTQ 97
Cdd:pfam15290   1 NQGSPVNNRDAYGPSSLSSSSNSGSCKGSDSSPTRRRSGRYHSCGDNHGIKPPNPEQYLTPLQQKEVTIRHLKTKLKESE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38202246    98 DRLQDRDTEIDDLKTQLSRMQEDWIEEECHRVEAQLALKEARKEIKQLKQVIDTVKNNLIDKDKGLQKYFVDINIQNKKL 177
Cdd:pfam15290  81 NRLQDRETEIEELKSQLSRMREDWIEEECHRVEAQLALKEARKEIKQLKQVIETMKSSLAEKDKGIQKYFVDINIQNKKL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38202246   178 ETLLHSMEVAQNGMAKEDGTGESAGGSPARSLTRSSTYTKLSDPAVcGDRQPGDPSSGSAEDGADSGFAAADDTLSRTDA 257
Cdd:pfam15290 161 ESLLQSMELAQNGSLRDEGTLEFACDSPAKSLTRSSTYTKLSDQLA-AEENGLELEDQSAEEMADSGLLANDEMANRTDL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38202246   258 LeassllssgvdcgtEETSLHSSFGLGPRFPASNTYEKLL---CGMEAGVQA-----SCMQERAIQTDFVQYQPDLDTIL 329
Cdd:pfam15290 240 L--------------EEVFMSTAVEAGDLAPFSSTYEKLMgsqKSVEALPSCseekqQMVEEQAIQTDVVPYSPDLDTLL 305
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 79-185 2.41e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 51.85  E-value: 2.41e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38202246  79 LQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEDW--IEEECHRVEAQLALKEARkeIKQLKQVIDTVKNNl 156
Cdd:COG1579  12 LQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELedLEKEIKRLELEIEEVEAR--IKKYEEQLGNVRNN- 88

                        90       100       110
                ....*....|....*....|....*....|....
gi 38202246 157 idKD-KGLQKyfvDINIQNKKLETL----LHSME 185
Cdd:COG1579  89 --KEyEALQK---EIESLKRRISDLedeiLELME 117
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 79-180 1.10e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 45.01  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38202246    79 LQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQlsrMQEDWIEE--------ECHRVEAQLALKEARKEIKQLKQVID 150
Cdd:TIGR04523 269 LSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQ---KEQDWNKElkselknqEKKLEEIQNQISQNNKIISQLNEQIS 345

                          90       100       110
                  ....*....|....*....|....*....|
gi 38202246   151 TVKNNLIDKDKGLQKYFVDINIQNKKLETL 180
Cdd:TIGR04523 346 QLKKELTNSESENSEKQRELEEKQNEIEKL 375
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
86-180 1.65e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 44.28  E-value: 1.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38202246   86 IRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEdwIEEEchrVEAQLALKEARKEIKQLKQVIDTVKNNLIDKDKGLQK 165
Cdd:PRK03918 254 KRKLEEKIRELEERIEELKKEIEELEEKVKELKE--LKEK---AEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEE 328

                         90
                 ....*....|....*
gi 38202246  166 YFVDINIQNKKLETL 180
Cdd:PRK03918 329 RIKELEEKEERLEEL 343
 
Name Accession Description Interval E-value
Syntaphilin pfam15290
Golgi-localized syntaxin-1-binding clamp; Syntaphilin or Syntabulin is a family of eukaryotic ...
 18-329 3.84e-170

Golgi-localized syntaxin-1-binding clamp; Syntaphilin or Syntabulin is a family of eukaryotic proteins. Syntaphilin binds to syntaxin-1 thereby inhibiting SNARE complex formation by absorbing free syntaxin-1. So it is a syntaxin-1 clamp that controls SNARE assembly.


Pssm-ID: 464617 [Multi-domain]  Cd Length: 305  Bit Score: 481.54  E-value: 3.84e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38202246    18 RTSPPVSVRDAYGTSSLSSSSNSGSYKGSDSSPTPRRSMKYTLCSDNHGIKPPTPEQYLTPLQQKEVCIRHLKARLKDTQ 97
Cdd:pfam15290   1 NQGSPVNNRDAYGPSSLSSSSNSGSCKGSDSSPTRRRSGRYHSCGDNHGIKPPNPEQYLTPLQQKEVTIRHLKTKLKESE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38202246    98 DRLQDRDTEIDDLKTQLSRMQEDWIEEECHRVEAQLALKEARKEIKQLKQVIDTVKNNLIDKDKGLQKYFVDINIQNKKL 177
Cdd:pfam15290  81 NRLQDRETEIEELKSQLSRMREDWIEEECHRVEAQLALKEARKEIKQLKQVIETMKSSLAEKDKGIQKYFVDINIQNKKL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38202246   178 ETLLHSMEVAQNGMAKEDGTGESAGGSPARSLTRSSTYTKLSDPAVcGDRQPGDPSSGSAEDGADSGFAAADDTLSRTDA 257
Cdd:pfam15290 161 ESLLQSMELAQNGSLRDEGTLEFACDSPAKSLTRSSTYTKLSDQLA-AEENGLELEDQSAEEMADSGLLANDEMANRTDL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38202246   258 LeassllssgvdcgtEETSLHSSFGLGPRFPASNTYEKLL---CGMEAGVQA-----SCMQERAIQTDFVQYQPDLDTIL 329
Cdd:pfam15290 240 L--------------EEVFMSTAVEAGDLAPFSSTYEKLMgsqKSVEALPSCseekqQMVEEQAIQTDVVPYSPDLDTLL 305
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 79-185 2.41e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 51.85  E-value: 2.41e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38202246  79 LQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEDW--IEEECHRVEAQLALKEARkeIKQLKQVIDTVKNNl 156
Cdd:COG1579  12 LQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELedLEKEIKRLELEIEEVEAR--IKKYEEQLGNVRNN- 88

                        90       100       110
                ....*....|....*....|....*....|....
gi 38202246 157 idKD-KGLQKyfvDINIQNKKLETL----LHSME 185
Cdd:COG1579  89 --KEyEALQK---EIESLKRRISDLedeiLELME 117
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 99-188 7.26e-06

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 47.23  E-value: 7.26e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38202246  99 RLQDRDTEIDDLKTQ-------LSRMQEDWIEEECHRVEAQLALKEARKEIKQLKQVIDTVKnNLIDKDKGLQKyfvdiN 171
Cdd:COG1579  11 DLQELDSELDRLEHRlkelpaeLAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVE-ARIKKYEEQLG-----N 84

                        90
                ....*....|....*...
gi 38202246 172 IQN-KKLETLLHSMEVAQ 188
Cdd:COG1579  85 VRNnKEYEALQKEIESLK 102
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 79-180 1.10e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 45.01  E-value: 1.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38202246    79 LQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQlsrMQEDWIEE--------ECHRVEAQLALKEARKEIKQLKQVID 150
Cdd:TIGR04523 269 LSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQ---KEQDWNKElkselknqEKKLEEIQNQISQNNKIISQLNEQIS 345

                          90       100       110
                  ....*....|....*....|....*....|
gi 38202246   151 TVKNNLIDKDKGLQKYFVDINIQNKKLETL 180
Cdd:TIGR04523 346 QLKKELTNSESENSEKQRELEEKQNEIEKL 375
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
81-193 1.56e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 44.12  E-value: 1.56e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38202246  81 QKEvcIRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQE--DWIEEECHRVEAQLA-----LKEARKEIKQLKQVIDTVK 153
Cdd:COG4372  44 QEE--LEQLREELEQAREELEQLEEELEQARSELEQLEEelEELNEQLQAAQAELAqaqeeLESLQEEAEELQEELEELQ 121

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 38202246 154 N---NLIDKDKGLQ----KYFVDINIQNKKLETLLHSMEVAQNGMAK 193
Cdd:COG4372 122 KerqDLEQQRKQLEaqiaELQSEIAEREEELKELEEQLESLQEELAA 168
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
86-180 1.65e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 44.28  E-value: 1.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38202246   86 IRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEdwIEEEchrVEAQLALKEARKEIKQLKQVIDTVKNNLIDKDKGLQK 165
Cdd:PRK03918 254 KRKLEEKIRELEERIEELKKEIEELEEKVKELKE--LKEK---AEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEE 328

                         90
                 ....*....|....*
gi 38202246  166 YFVDINIQNKKLETL 180
Cdd:PRK03918 329 RIKELEEKEERLEEL 343
BAR pfam03114
BAR domain; BAR domains are dimerization, lipid binding and curvature sensing modules found in ...
 116-189 2.97e-04

BAR domain; BAR domains are dimerization, lipid binding and curvature sensing modules found in many different protein families. A BAR domain with an additional N-terminal amphipathic helix (an N-BAR) can drive membrane curvature. These N-BAR domains are found in amphiphysin, endophilin, BRAP and Nadrin. BAR domains are also frequently found alongside domains that determine lipid specificity, like pfam00169 and pfam00787 domains in beta centaurins and sorting nexins respectively.


Pssm-ID: 460810 [Multi-domain]  Cd Length: 235  Bit Score: 42.32  E-value: 2.97e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 38202246   116 RMQEDWieEECHRVEAQLALKEARKEIKQ-LKQVIDTVKNNLIDKDKGLQKYFVDINIQNKKLETLLHSMEVAQN 189
Cdd:pfam03114  80 AGKDLG--EDSSFGKALEDYGEALKRLAQlLEQLDDRVETNFLDPLRNLLKEFKEIQKHRKKLERKRLDYDAAKT 152
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 80-194 7.07e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 42.31  E-value: 7.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38202246    80 QQKEVCIRHLKARLKDTQDRLQDRDTE-------IDDLKTQLSRMQEDWIEEECHRVEAQLALKEARKEIKQLKQVIDTV 152
Cdd:TIGR04523 303 QKEQDWNKELKSELKNQEKKLEEIQNQisqnnkiISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSY 382

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 38202246   153 KN---NLIDKDKGLQKYFVDINIQNKKLETLLHSMEVAQNGMAKE 194
Cdd:TIGR04523 383 KQeikNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKE 427
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
79-194 7.84e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 41.81  E-value: 7.84e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38202246  79 LQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEDW--IEEECHRVEAQLA-----LKEARKEIKQLKQVIDT 151
Cdd:COG4372  61 LEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELesLQEEAEELQEELEelqkeRQDLEQQRKQLEAQIAE 140

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 38202246 152 VKNNLIDKDKGLQKYFVDINIQNKKLETLLHSMEVAQNGMAKE 194
Cdd:COG4372 141 LQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQ 183
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 105-180 9.15e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 41.93  E-value: 9.15e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38202246   105 TEIDDLKTQLSRMQEDWIEEECHRVEAQLALKEARKEIKQLKQVIDTVKNNLIDKDKglqkyfvDINIQNKKLETL 180
Cdd:TIGR04523 218 SQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQK-------ELEQNNKKIKEL 286
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 79-183 9.56e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 41.93  E-value: 9.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38202246    79 LQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQED--WIEEECHRVEAQLALKEarKEIKQLKQVI----DTV 152
Cdd:TIGR04523 365 LEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLnqQKDEQIKKLQQEKELLE--KEIERLKETIiknnSEI 442

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 38202246   153 KnNLIDKDKGLQKYFVDIN----IQNKKLETLLHS 183
Cdd:TIGR04523 443 K-DLTNQDSVKELIIKNLDntreSLETQLKVLSRS 476
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 86-180 1.46e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 41.16  E-value: 1.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38202246    86 IRHLKARLKDTQDRLQDRDTEIDDLKTQLSRM--QEDWIEEECHRVEAQLalKEARKEIKQLKQVIDTVKNNLIDKDKGL 163
Cdd:TIGR04523  77 IKILEQQIKDLNDKLKKNKDKINKLNSDLSKInsEIKNDKEQKNKLEVEL--NKLEKQKKENKKNIDKFLTEIKKKEKEL 154

                          90
                  ....*....|....*..
gi 38202246   164 QKYFVDINIQNKKLETL 180
Cdd:TIGR04523 155 EKLNNKYNDLKKQKEEL 171
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 73-188 2.12e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.52  E-value: 2.12e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38202246  73 EQYLTPLQQKevcIRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEDWIEEECHRVEAQLALKEARKEIKQLKQVIDTV 152
Cdd:COG4942  26 EAELEQLQQE---IAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQ 102

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 38202246 153 KNNLIDKDKGLQKyfvdiNIQNKKLETLLHSMEVAQ 188
Cdd:COG4942 103 KEELAELLRALYR-----LGRQPPLALLLSPEDFLD 133
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 77-183 3.64e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 39.81  E-value: 3.64e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38202246  77 TPLQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEDwieeechrveaqlaLKEARKEIKQLKQVIDTVKNNL 156
Cdd:COG3883  16 PQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAE--------------LEALQAEIDKLQAEIAEAEAEI 81

                        90       100       110
                ....*....|....*....|....*....|
gi 38202246 157 IDKDKGLQKYFVDINIQ---NKKLETLLHS 183
Cdd:COG3883  82 EERREELGERARALYRSggsVSYLDVLLGS 111
46 PHA02562
endonuclease subunit; Provisional
 89-188 4.14e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 39.61  E-value: 4.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38202246   89 LKARLKDTQDRLQDRDTEIDDLKTQLsRMQEDWIEE-----ECHRVEAQLALKEARKEIKQLKQVIDTVKNNLIDKDKGL 163
Cdd:PHA02562 172 NKDKIRELNQQIQTLDMKIDHIQQQI-KTYNKNIEEqrkknGENIARKQNKYDELVEEAKTIKAEIEELTDELLNLVMDI 250

                         90       100
                 ....*....|....*....|....*..
gi 38202246  164 QKYFVDINiqnkKLETLLH--SMEVAQ 188
Cdd:PHA02562 251 EDPSAALN----KLNTAAAkiKSKIEQ 273
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
86-193 4.48e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 39.50  E-value: 4.48e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38202246  86 IRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQedwieEECHRVEAQlaLKEARKEIKQLKQvidtvknNLIDKDKGLQK 165
Cdd:COG4372  26 IAALSEQLRKALFELDKLQEELEQLREELEQAR-----EELEQLEEE--LEQARSELEQLEE-------ELEELNEQLQA 91

                        90       100
                ....*....|....*....|....*...
gi 38202246 166 YFVDINIQNKKLETLLHSMEVAQNGMAK 193
Cdd:COG4372  92 AQAELAQAQEELESLQEEAEELQEELEE 119
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
86-185 7.91e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 39.13  E-value: 7.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38202246   86 IRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQE----------------DW--IEEECHRVEAQLA--------LKEAR 139
Cdd:COG4913  612 LAALEAELAELEEELAEAEERLEALEAELDALQErrealqrlaeyswdeiDVasAEREIAELEAELErldassddLAALE 691

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 38202246  140 KEIKQLKQVIDTVKNNLIDKDK---GLQKYFVDINIQNKKLETLLHSME 185
Cdd:COG4913  692 EQLEELEAELEELEEELDELKGeigRLEKELEQAEEELDELQDRLEAAE 740
TPR_MLP1_2 pfam07926
TPR/MLP1/MLP2-like protein; The sequences featured in this family are similar to a region of ...
 86-183 7.95e-03

TPR/MLP1/MLP2-like protein; The sequences featured in this family are similar to a region of human TPR protein and to yeast myosin-like proteins 1 (MLP1) and 2 (MLP2). These proteins share a number of features; for example, they all have coiled-coil regions and all three are associated with nuclear pores. TPR is thought to be a component of nuclear pore complex- attached intra-nuclear filaments, and is implicated in nuclear protein import. Moreover, its N-terminal region is involved in the activation of oncogenic kinases, possibly by mediating the dimerization of kinase domains or by targeting these kinases to the nuclear pore complex. MLP1 and MLP2 are involved in the process of telomere length regulation, where they are thought to interact with proteins such as Tel1p and modulate their activity.


Pssm-ID: 462316 [Multi-domain]  Cd Length: 129  Bit Score: 36.46  E-value: 7.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38202246    86 IRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQEDWIEEEchrveaqlalKEARKEIKQLKQVIDtvknnlidkdkglqk 165
Cdd:pfam07926  59 LQALREELNELKAEIAELKAEAESAKAELEESEESWEEQK----------KELEKELSELEKRIE--------------- 113

                          90
                  ....*....|....*...
gi 38202246   166 yfvDINIQNKkletLLHS 183
Cdd:pfam07926 114 ---DLNEQNK----LLHD 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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