|
Name |
Accession |
Description |
Interval |
E-value |
| COG5028 |
COG5028 |
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ... |
132-1027 |
1.39e-166 |
|
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];
Pssm-ID: 227361 [Multi-domain] Cd Length: 861 Bit Score: 511.26 E-value: 1.39e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 132 YGSGMAPPSQGPPGPlSATSLQTPPRPPQPSILQPGSQVLPPPPTTlngpgaSPLPLPMYRPDGLSGPPPPNAQYQPPPl 211
Cdd:COG5028 4 HKKGVYPQAQSQVHT-GAASSKKSARPHRAYANFSAGQMGMPPYTT------PPLQQQSRRQIDQAATAMHNTGANNPA- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 212 pgQTLGAGYPPQQANsgpqmagaqlsYPGGFPGGPAQMAGPPQpqkkldpdSIPSPIQVIENDRASRGGQVYATnTRGQI 291
Cdd:COG5028 76 --PSVMSPAFQSQQK-----------FSSPYGGSMADGTAPKP--------TNPLVPVDLFEDQPPPISDLFLP-PPPIV 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 292 PPLvTTDCMIQDQGNASPRFIRCTTYCFPCTSDMAKQAQIPLAAVIKPFATIPSNESPLYLVNHGEsgPVRCNRCKAYMC 371
Cdd:COG5028 134 PPL-TTNFVGSEQSNCSPKYVRSTMYAIPETNDLLKKSKIPFGLVIRPFLELYPEEDPVPLVEDGS--IVRCRRCRSYIN 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 372 PFMQFIEGGRRYQCGFCNCVNDVPPFYFQHLDHIGRRLDHYEKPELSLGSYEYVATLDYcrKSKPPNPPAFIFMIDVSYS 451
Cdd:COG5028 211 PFVQFIEQGRKWRCNICRSKNDVPEGFDNPSGPNDPRSDRYSRPELKSGVVDFLAPKEY--SLRQPPPPVYVFLIDVSFE 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 452 NIKNGLVKLICEELKTMLEKIPKEEQEetsaIRVGFITYNKVLHFFNVKSNLaQPQMMVVTDVGEVFVPLLDG-FLVNYQ 530
Cdd:COG5028 289 AIKNGLVKAAIRAILENLDQIPNFDPR----TKIAIICFDSSLHFFKLSPDL-DEQMLIVSDLDEPFLPFPSGlFVLPLK 363
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 531 ESQSVIHNLLDQIPDMFADSNENETVFAPVIQAGMEALKAadCPGKLFIFHSSLPTAeAPGKLKNRDDKklvntdkEKIL 610
Cdd:COG5028 364 SCKQIIETLLDRVPRIFQDNKSPKNALGPALKAAKSLIGG--TGGKIIVFLSTLPNM-GIGKLQLREDK-------ESSL 433
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 611 FQPQTNVYDSLAKDCVAHGCSVTLFLFPSQYVDVASLGLVPQLTGGTLYKYNNFQM--HLDRQQFLNDLRNDIEKKIGFD 688
Cdd:COG5028 434 LSCKDSFYKEFAIECSKVGISVDLFLTSEDYIDVATLSHLCRYTGGQTYFYPNFSAtrPNDATKLANDLVSHLSMEIGYE 513
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 689 AIMRVRTSTGFRATDFFGGILMNNTTDVEMAAIDCDKAVTVEFKHDDKLSeDSGALIQCAVLYTTISGQRRLRIHNLGLN 768
Cdd:COG5028 514 AVMRVRCSTGLRVSSFYGNFFNRSSDLCAFSTMPRDTSLLVEFSIDEKLM-TSDVYFQVALLYTLNDGERRIRVVNLSLP 592
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 769 CSSQLADLYKSCETDALINFFAKSAFKAVLHQPLKVIREILVNQTAHMLACYRKNCASPSAASQLILPDSMKVLPVYMNC 848
Cdd:COG5028 593 TSSSIREVYASADQLAIACILAKKASTKALNSSLKEARVLINKSMVDILKAYKKELVKSNTSTQLPLPANLKLLPLLMLA 672
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 849 LLKNcVLLSRPEISTDERAYQRQLVMTMGVADSQLFFYPQLLPIHTL-------DVKSTMLPAAVRCSESRLSEEGIFLL 921
Cdd:COG5028 673 LLKS-SAFRSGSTPSDIRISALNRLTSLPLKQLMRNIYPTLYALHDMpieaglpDEGLLVLPSPINATSSLLESGGLYLI 751
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 922 ANGLHMFLWLGVSSPPELIQGIFNVPSFAHINTDMTLLPEVGNPYSQQLRMIMGIIQQKRPYS-MKLTIVKQREQP--EM 998
Cdd:COG5028 752 DTGQKIFLWFGKDAVPSLLQDLFGVDSLSDIPSGKFTLPPTGNEFNERVRNIIGELRSVNDDStLPLVLVRGGGDPslRL 831
|
890 900
....*....|....*....|....*....
gi 190343021 999 VFRQFLVEDKgLYGGSSYVDFLCCVHKEI 1027
Cdd:COG5028 832 WFFSTLVEDK-TLNIPSYLDYLQILHEKI 859
|
|
| Sec24-like |
cd01479 |
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ... |
437-696 |
7.39e-119 |
|
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.
Pssm-ID: 238756 [Multi-domain] Cd Length: 244 Bit Score: 364.29 E-value: 7.39e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 437 PNPPAFIFMIDVSYSNIKNGLVKLICEELKTMLEKIPKEEqeetSAIRVGFITYNKVLHFFNVKSNLAQPQMMVVTDVGE 516
Cdd:cd01479 1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGDD----PRTRVGFITFDSTLHFFNLKSSLEQPQMMVVSDLDD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 517 VFVPLLDGFLVNYQESQSVIHNLLDQIPDMFADSNENETVFAPVIQAGMEALKaaDCPGKLFIFHSSLPTAEApGKLKNR 596
Cdd:cd01479 77 PFLPLPDGLLVNLKESRQVIEDLLDQIPEMFQDTKETESALGPALQAAFLLLK--ETGGKIIVFQSSLPTLGA-GKLKSR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 597 DDKKLVNTDKEKILFQPQTNVYDSLAKDCVAHGCSVTLFLFPSQYVDVASLGLVPQLTGGTLYKYNNFQmhldrqqflND 676
Cdd:cd01479 154 EDPKLLSTDKEKQLLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYYPSFN---------FS 224
|
250 260
....*....|....*....|
gi 190343021 677 LRNDIEKKIGFDAIMRVRTS 696
Cdd:cd01479 225 APNDVEKLVNELARYLTRKI 244
|
|
| Sec23_trunk |
pfam04811 |
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ... |
437-681 |
6.32e-111 |
|
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.
Pssm-ID: 398467 [Multi-domain] Cd Length: 241 Bit Score: 343.46 E-value: 6.32e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 437 PNPPAFIFMIDVSYSNIKNGLVKLICEELKTMLEKIPKEeqeetSAIRVGFITYNKVLHFFNVKSNLAQPQMMVVTDVGE 516
Cdd:pfam04811 1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGD-----PRARVGFITFDSTVHFFNLGSSLRQPQMLVVSDLQD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 517 VFVPLLDGFLVNYQESQSVIHNLLDQIPDMFADSNENETVFAPVIQAGMEALKAADCPGKLFIFHSSLPTAEAPGKLKNR 596
Cdd:pfam04811 76 MFLPLPDRFLVPLSECRFVLEDLLEQLPPMFPVTKRPERCLGPALQAAFLLLKAAFTGGKIMVFQGGLPTVGPGGKLKSR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 597 DDKKLVNTDKEKILFQPQTN-VYDSLAKDCVAHGCSVTLFLFPSQYVDVASLGLVPQLTGGTLYKYNNFQMHLDRQQFLN 675
Cdd:pfam04811 156 LDESHHGTDKEKAKLVKKADkFYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADVDGSKFKQ 235
|
....*.
gi 190343021 676 DLRNDI 681
Cdd:pfam04811 236 DLQRYF 241
|
|
| trunk_domain |
cd01468 |
trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi ... |
437-677 |
7.13e-98 |
|
trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface. Some members of this family possess a partial MIDAS motif that is a characteristic feature of most vWA domain proteins.
Pssm-ID: 238745 [Multi-domain] Cd Length: 239 Bit Score: 308.79 E-value: 7.13e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 437 PNPPAFIFMIDVSYSNIKNGLVKLICEELKTMLEKIPKEeqeetSAIRVGFITYNKVLHFFNVKSNLAQPQMMVVTDVGE 516
Cdd:cd01468 1 PQPPVFVFVIDVSYEAIKEGLLQALKESLLASLDLLPGD-----PRARVGLITYDSTVHFYNLSSDLAQPKMYVVSDLKD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 517 VFVPLLDGFLVNYQESQSVIHNLLDQIPDMFAD--SNENETVFAPVIQAGMEALKAADCPGKLFIFHSSLPTAEaPGKLK 594
Cdd:cd01468 76 VFLPLPDRFLVPLSECKKVIHDLLEQLPPMFWPvpTHRPERCLGPALQAAFLLLKGTFAGGRIIVFQGGLPTVG-PGKLK 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 595 NRDDKKLVNTDKEKILFQPQTNVYDSLAKDCVAHGCSVTLFLFPSQYVDVASLGLVPQLTGGTLYKYNNFQMHLDRQQFL 674
Cdd:cd01468 155 SREDKEPIRSHDEAQLLKPATKFYKSLAKECVKSGICVDLFAFSLDYVDVATLKQLAKSTGGQVYLYDSFQAPNDGSKFK 234
|
...
gi 190343021 675 NDL 677
Cdd:cd01468 235 QDL 237
|
|
| PTZ00395 |
PTZ00395 |
Sec24-related protein; Provisional |
439-1025 |
1.45e-50 |
|
Sec24-related protein; Provisional
Pssm-ID: 185594 [Multi-domain] Cd Length: 1560 Bit Score: 195.29 E-value: 1.45e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 439 PPAFIFMIDVSYSNIKNGLVKLICEELKTMLEKIpkeeqeETSAIRVGFITYNKVLHFFNVKSNLAQP------------ 506
Cdd:PTZ00395 952 PPYFVFVVECSYNAIYNNITYTILEGIRYAVQNV------KCPQTKIAIITFNSSIYFYHCKGGKGVSgeegdggggsgn 1025
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 507 -QMMVVTDVGEVFVPL-LDGFLVNYQESQSVIHNLLDQIPDMFADSNENETVFAPVIQAGMEALKAADCPGKLFIFHSSL 584
Cdd:PTZ00395 1026 hQVIVMSDVDDPFLPLpLEDLFFGCVEEIDKINTLIDTIKSVSTTMQSYGSCGNSALKIAMDMLKERNGLGSICMFYTTT 1105
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 585 PTAeAPGKLKnrddkKLVNTDKEKILFQPQTNVYDSLAKDCVAHGCSVTLFLFPSQYVDVA--SLGLVPQLTGGTLYKYN 662
Cdd:PTZ00395 1106 PNC-GIGAIK-----ELKKDLQENFLEVKQKIFYDSLLLDLYAFNISVDIFIISSNNVRVCvpSLQYVAQNTGGKILFVE 1179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 663 NFQMHLDRQQ-FLNDLRNDIEKKIGFDAIMRVRTSTG------FRATDFFGGILMNNTtdVEMAAIDCDKAVTVEFKHDD 735
Cdd:PTZ00395 1180 NFLWQKDYKEiYMNIMDTLTSEDIAYCCELKLRYSHHmsvkklFCCNNNFNSIISVDT--IKIPKIRHDQTFAFLLNYSD 1257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 736 KLSEDSGALIQCAVLYTTISGQRRLRIHNLGLNCSSQLADLYKSCETDALINFFAKSAFKAVLHQplKVIREILVNQTAH 815
Cdd:PTZ00395 1258 ISESKKQIYFQCACIYTNLWGDRFVRLHTTHMNLTSSLSTVFRYTDAEALMNILIKQLCTNILHN--DNYSKIIIDNLAA 1335
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 816 MLACYRKNCASPSAASQLILPDSMKVLPVYMNCLLKNCVllSRPEISTDERAYQRQLVMTMGVADSQLFFYPQLLPIH-- 893
Cdd:PTZ00395 1336 ILFSYRINCASSAHSGQLILPDTLKLLPLFTSSLLKHNV--TKKEILHDLKVYSLIKLLSMPIISSLLYVYPVMYVIHik 1413
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 894 -------TLDVKSTM-LPAAVRCSESRLSEEGIFLLANGLHMFLWLGVSSPPELIQGIF-NVPSFAHINTdmtlLPEVGN 964
Cdd:PTZ00395 1414 gktneidSMDVDDDLfIPKTIPSSAEKIYSNGIYLLDACTHFYLYFGFHSDANFAKEIVgDIPTEKNAHE----LNLTDT 1489
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 190343021 965 PYSQQLRMIMGIIQQKRPYS--MKLTIVKQREQPEMVFRQFLVEDKGlYGGSSYVDFLCCVHK 1025
Cdd:PTZ00395 1490 PNAQKVQRIIKNLSRIHHFNkyVPLVMVAPKSNEEEHLISLCVEDKA-DKEYSYVNFLCFIHK 1551
|
|
| Sec23_helical |
pfam04815 |
Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic ... |
783-883 |
1.57e-32 |
|
Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is composed of five alpha helices.
Pssm-ID: 461441 [Multi-domain] Cd Length: 103 Bit Score: 121.84 E-value: 1.57e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 783 DALINFFAKSAFKAVLHQPLKVIREILVNQTAHMLACYRKNCASPSAASQLILPDSMKVLPVYMNCLLKNCVLLSRPEIS 862
Cdd:pfam04815 3 EAIAVLLAKKAVEKALSSSLSDAREALDNKLVDILAAYRKYCASSSSPGQLILPESLKLLPLYMLALLKSPALRGGNSSP 82
|
90 100
....*....|....*....|.
gi 190343021 863 TDERAYQRQLVMTMGVADSQL 883
Cdd:pfam04815 83 SDERAYARHLLLSLPVEELLL 103
|
|
| Sec23_BS |
pfam08033 |
Sec23/Sec24 beta-sandwich domain; |
686-770 |
4.52e-29 |
|
Sec23/Sec24 beta-sandwich domain;
Pssm-ID: 429794 [Multi-domain] Cd Length: 86 Bit Score: 111.09 E-value: 4.52e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 686 GFDAIMRVRTSTGFRATDFFGGILMNNTTD-VEMAAIDCDKAVTVEFKHDDKLSEDSGALIQCAVLYTTISGQRRLRIHN 764
Cdd:pfam08033 1 GFNAVLRVRTSKGLKVSGFIGNFVSRSSGDtWKLPSLDPDTSYAFEFDIDEPLPNGSNAYIQFALLYTHSSGERRIRVTT 80
|
....*.
gi 190343021 765 LGLNCS 770
Cdd:pfam08033 81 VALPVT 86
|
|
| SEC23 |
COG5047 |
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion]; |
312-900 |
1.71e-21 |
|
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];
Pssm-ID: 227380 [Multi-domain] Cd Length: 755 Bit Score: 100.73 E-value: 1.71e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 312 IRCTTYCFPCTSDMAKQAQIPLAAVIKPFatipsNESPLYLVNHGEsgPVRCNR-CKAYMCPFMQFIEGGRRYQCGFCNC 390
Cdd:COG5047 12 IRLTWNVFPATRGDATRTVIPIACLYTPL-----HEDDALTVNYYE--PVKCTApCKAVLNPYCHIDERNQSWICPFCNQ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 391 VNDVPPFYfqhldhigRRLDHYEKP-ELSLGS--YEYVAtldycrkSKPPN-PPAFIFMIDVSYSNIKNGLVKlicEELK 466
Cdd:COG5047 85 RNTLPPQY--------RDISNANLPlELLPQSstIEYTL-------SKPVIlPPVFFFVVDACCDEEELTALK---DSLI 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 467 TMLEKIPKEeqeetsAIrVGFITYNKVLHFFNV------KSNLAQP----QMMVVTDVGEVFVPLLDG------------ 524
Cdd:COG5047 147 VSLSLLPPE------AL-VGLITYGTSIQVHELnaenhrRSYVFSGnkeyTKENLQELLALSKPTKSGgfeskisgigqf 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 525 ----FLVNYQESQSVIHNLLDQI-PDMFADSNENE----TVFAPVIQAGMEALKAADCPGKLFIFHSSlPTAEAPGKLKN 595
Cdd:COG5047 220 assrFLLPTQQCEFKLLNILEQLqPDPWPVPAGKRplrcTGSALNIASSLLEQCFPNAGCHIVLFAGG-PCTVGPGTVVS 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 596 RDDKK------LVNTDKEKiLFQPQTNVYDSLAKDCVAHGCSVTLFLfpSQYVDVASLGLVP--QLTGGTLYKYNNFQMH 667
Cdd:COG5047 299 TELKEpmrshhDIESDSAQ-HSKKATKFYKGLAERVANQGHALDIFA--GCLDQIGIMEMEPltTSTGGALVLSDSFTTS 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 668 LDRQQFLN--DLRNDIEKKIGFDAIMRVRTSTGFRATDFFG---------------GILMNNTTDVEMAAIDCDKAVTVE 730
Cdd:COG5047 376 IFKQSFQRifNRDSEGYLKMGFNANMEVKTSKNLKIKGLIGhavsvkkkannisdsEIGIGATNSWKMASLSPKSNYALY 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 731 FK-----HDDKLSEDSGALIQCAVLYTTISGQRRLRIHNLGLNCSSQLADL-YKSCETDALINFFAK-SAFKAVLHQPLK 803
Cdd:COG5047 456 FEialgaASGSAQRPAEAYIQFITTYQHSSGTYRIRVTTVARMFTDGGLPKiNRSFDQEAAAVFMARiAAFKAETEDIID 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 804 VIREI---LVNQTAHmLACYRKNcaspsAASQLILPDSMKVLPVYMnCLLKNCVLLSRPEISTDERAYQRQLVMTMGVAD 880
Cdd:COG5047 536 VFRWIdrnLIRLCQK-FADYRKD-----DPSSFRLDPNFTLYPQFM-YHLRRSPFLSVFNNSPDETAFYRHMLNNADVND 608
|
650 660
....*....|....*....|....*...
gi 190343021 881 SQLFFYPQLLPIH--------TLDVKST 900
Cdd:COG5047 609 SLIMIQPTLQSYSfekggvpvLLDSVSV 636
|
|
| zf-Sec23_Sec24 |
pfam04810 |
Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum ... |
360-396 |
1.06e-15 |
|
Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is found to be zinc binding domain.
Pssm-ID: 461437 [Multi-domain] Cd Length: 38 Bit Score: 71.71 E-value: 1.06e-15
10 20 30
....*....|....*....|....*....|....*..
gi 190343021 360 PVRCNRCKAYMCPFMQFIEGGRRYQCGFCNCVNDVPP 396
Cdd:pfam04810 1 PVRCRRCRAYLNPFCQFDFGGKKWTCNFCGTRNPVPP 37
|
|
| PLN00162 |
PLN00162 |
transport protein sec23; Provisional |
312-656 |
6.13e-11 |
|
transport protein sec23; Provisional
Pssm-ID: 215083 [Multi-domain] Cd Length: 761 Bit Score: 66.50 E-value: 6.13e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 312 IRCTTYCFPCTSDMAKQAQIPLAAVIKPFAtiPSNESPL--YlvnhgesGPVRCNRCKAYMCPFMQFIEGGRRYQCGFCN 389
Cdd:PLN00162 12 VRMSWNVWPSSKIEASKCVIPLAALYTPLK--PLPELPVlpY-------DPLRCRTCRAVLNPYCRVDFQAKIWICPFCF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 390 CVNDVPPFYFQhldhIGrrlDHYEKPELslgsYEYVATLDY---CRKSKPPNPPAFIFMIDVSYSNIKNGLVKlicEELK 466
Cdd:PLN00162 83 QRNHFPPHYSS----IS---ETNLPAEL----FPQYTTVEYtlpPGSGGAPSPPVFVFVVDTCMIEEELGALK---SALL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 467 TMLEKIPkeeqeETSaiRVGFITY----------------------------NKVLHFFNVKSNLAQPQMMVVTDVGEVF 518
Cdd:PLN00162 149 QAIALLP-----ENA--LVGLITFgthvhvhelgfsecsksyvfrgnkevskDQILEQLGLGGKKRRPAGGGIAGARDGL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 519 VPL-LDGFLVNYQESQSVIHNLLDQI-PDMFADSNENE----TVFAPVIQAGMEALKAADCPGKLFIFHSSlPTAEAPGK 592
Cdd:PLN00162 222 SSSgVNRFLLPASECEFTLNSALEELqKDPWPVPPGHRparcTGAALSVAAGLLGACVPGTGARIMAFVGG-PCTEGPGA 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 190343021 593 LKNRDDKKLVNTDKEKI-----LFQPQTNVYDSLAKDCVAHGCSVTLFLFPSQYVDVASLGLVPQLTGG 656
Cdd:PLN00162 301 IVSKDLSEPIRSHKDLDkdaapYYKKAVKFYEGLAKQLVAQGHVLDVFACSLDQVGVAEMKVAVERTGG 369
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
96-269 |
2.47e-10 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 64.70 E-value: 2.47e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 96 SHAPyQPSAQSSYPGPISTSSVTQLGSQLSAMQINSYGSGMAPPsQGPPGPLSATSLQTPPRPPQPSILQPGSQVLPP-P 174
Cdd:PHA03378 613 SHIP-ETSAPRQWPMPLRPIPMRPLRMQPITFNVLVFPTPHQPP-QVEITPYKPTWTQIGHIPYQPSPTGANTMLPIQwA 690
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 175 PTTLNGPGASPLPL--------PMYRPDGLSGPPPPNAQYQPPPLPGQTLGAGYPPQQANSG----PQMAGAQLSYPGGF 242
Cdd:PHA03378 691 PGTMQPPPRAPTPMrppaappgRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGrarpPAAAPGRARPPAAA 770
|
170 180 190
....*....|....*....|....*....|
gi 190343021 243 PGGPAQM---AGPPQPQKKldPDSIPSPIQ 269
Cdd:PHA03378 771 PGAPTPQpppQAPPAPQQR--PRGAPTPQP 798
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
8-293 |
6.09e-10 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 63.80 E-value: 6.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 8 ATPPYSQPQPGIGLSPPHYGhygDPSHTASPTGMMKPAGPlGATATRGMLPPGPPPPGPhqfgqnGAHATGHPPQRFPGP 87
Cdd:PHA03247 2718 ATPLPPGPAAARQASPALPA---APAPPAVPAGPATPGGP-ARPARPPTTAGPPAPAPP------AAPAAGPPRRLTRPA 2787
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 88 PPVNNVASSHAPyQPSAQSSYPGPISTSSVTQLGSQLSAmqinsygSGMAPPSQGPPgplsaTSLQTPPRPPQPSiLQPG 167
Cdd:PHA03247 2788 VASLSESRESLP-SPWDPADPPAAVLAPAAALPPAASPA-------GPLPPPTSAQP-----TAPPPPPGPPPPS-LPLG 2853
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 168 SQVLPPPPTTLNGPGASPLPLP----------MYRPdGLSGPPPPNAQYQPPPLPGQTlgagyPPQQANSGPQMAGAQLS 237
Cdd:PHA03247 2854 GSVAPGGDVRRRPPSRSPAAKPaaparppvrrLARP-AVSRSTESFALPPDQPERPPQ-----PQAPPPPQPQPQPPPPP 2927
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 190343021 238 YPGGFPGGPAQMAGPPQPQKKLDPDSIPSPIQVIENDRASRGGQVYAtnTRGQIPP 293
Cdd:PHA03247 2928 QPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAV--PRFRVPQ 2981
|
|
| Gelsolin |
pfam00626 |
Gelsolin repeat; |
899-974 |
1.06e-09 |
|
Gelsolin repeat;
Pssm-ID: 395501 [Multi-domain] Cd Length: 76 Bit Score: 55.78 E-value: 1.06e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 190343021 899 STMLPAAVRCSESRLSEEGIFLLANGLHMFLWLGVSSppELIQGIFNVPSFAHINTDM-TLLPEVGN-PYSQQLRMIM 974
Cdd:pfam00626 1 KFVLPPPVPLSQESLNSGDCYLLDNGFTIFLWVGKGS--SLLEKLFAALLAAQLDDDErFPLPEVIRvPQGKEPARFL 76
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
96-255 |
1.50e-09 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 62.09 E-value: 1.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 96 SHAPYQPSAQSSYPGPISTSSVTQLGSQLSAMQINSygsgmAPPSQGPPGPLSATSLQTP-PRPPQPSILQPGSQVLPPP 174
Cdd:pfam03154 143 STSPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQS-----GAASPPSPPPPGTTQAATAgPTPSAPSVPPQGSPATSQP 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 175 PTTLNGPgASPLPL----PMYRPDGLSGPPPPNAQYQPPPLPGQTlgagypPQQANSGPQMAGAQLSYPGGFPGGPAQM- 249
Cdd:pfam03154 218 PNQTQST-AAPHTLiqqtPTLHPQRLPSPHPPLQPMTQPPPPSQV------SPQPLPQPSLHGQMPPMPHSLQTGPSHMq 290
|
....*..
gi 190343021 250 -AGPPQP 255
Cdd:pfam03154 291 hPVPPQP 297
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
93-273 |
1.83e-08 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 58.63 E-value: 1.83e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 93 VASSHAPYQPSAQSSYPGPISTSSVTQLGSQLSAMQINSYGSGMAPPS---QGP-------PGPLSATSLQTPPRPPQPS 162
Cdd:pfam03154 182 SPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTliqQTPtlhpqrlPSPHPPLQPMTQPPPPSQV 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 163 ILQPGSQV-----LPPPPTTLN-GPGASPLPLPmyrPDGLsGPPPPNAQYQPPPLPGQTLGAGYPPQQANSGPQMAGAQL 236
Cdd:pfam03154 262 SPQPLPQPslhgqMPPMPHSLQtGPSHMQHPVP---PQPF-PLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQ 337
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 190343021 237 SYPGGFPGGPAQMAGP-------------PQPQKKLDPD--SIPSPIQVIEN 273
Cdd:pfam03154 338 QPPREQPLPPAPLSMPhikpppttpipqlPNPQSHKHPPhlSGPSPFQMNSN 389
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
7-288 |
5.42e-08 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 57.26 E-value: 5.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 7 VATPPYSQPQPGIGLSPPHYGHYGDPSHTASPTGMMKPAGPLGATATRgmlppgppppgphqfgqngahatghppqrfpg 86
Cdd:PHA03247 2776 AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAS-------------------------------- 2823
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 87 pppvnnvASSHAPYQPSAQSSYPGPISTSSVTQLgsqlsamqinSYGSGMAP----PSQGPPGPlSATSLQTPPRPPQPS 162
Cdd:PHA03247 2824 -------PAGPLPPPTSAQPTAPPPPPGPPPPSL----------PLGGSVAPggdvRRRPPSRS-PAAKPAAPARPPVRR 2885
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 163 ILQPgsqvlPPPPTTlngpgaSPLPLPmyrPDGLSGPPPPNAQYQP---PPLPGQTLGAGYPPQQANSGPQMAGAQLSYP 239
Cdd:PHA03247 2886 LARP-----AVSRST------ESFALP---PDQPERPPQPQAPPPPqpqPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAG 2951
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 190343021 240 GGFPGGpaqmaGPPQPQ-KKLDPDSIPSPIQVIENDRASRGGQVYATNTR 288
Cdd:PHA03247 2952 AGEPSG-----AVPQPWlGALVPGRVAVPRFRVPQPAPSREAPASSTPPL 2996
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
99-289 |
6.90e-08 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 56.70 E-value: 6.90e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 99 PYQPSAQS-SYPGPISTSSVTQLGSQLS---AMQINSYGSGMAPPSQGPPgPLS--ATSLQTPPRPPQPSILQPgSQVLP 172
Cdd:pfam03154 364 PQLPNPQShKHPPHLSGPSPFQMNSNLPpppALKPLSSLSTHHPPSAHPP-PLQlmPQSQQLPPPPAQPPVLTQ-SQSLP 441
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 173 P-----PPTTLNGPGASPLPLPMYrPDGLSGPPPPNAQYQPPPLPGQTLGAGYPPQQAN---SGPQMAGAQLSYPggfpg 244
Cdd:pfam03154 442 PpaashPPTSGLHQVPSQSPFPQH-PFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASvssSGPVPAAVSCPLP----- 515
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 190343021 245 gPAQMAGPP-----QPQKKLDPDSIPSPIQVIEN--DRASRGGQVYATNTRG 289
Cdd:pfam03154 516 -PVQIKEEAldeaeEPESPPPPPRSPSPEPTVVNtpSHASQSARFYKHLDRG 566
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
10-261 |
8.34e-08 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 56.87 E-value: 8.34e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 10 PPYSQPQPGIGLSPPHYGHYGDPSHTASPTGMMKPAGPLGATATRGMLPPGPPPPGPHQFGQNGAHATGHPPQRFPGPPP 89
Cdd:PHA03247 2741 PPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPP 2820
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 90 VNNVASSHAP---YQPSAQSSYPGPISTSSVTQlGSQLSAMQINSYGSGMAPPSQ-------------GPPGPLSATSLQ 153
Cdd:PHA03247 2821 AASPAGPLPPptsAQPTAPPPPPGPPPPSLPLG-GSVAPGGDVRRRPPSRSPAAKpaaparppvrrlaRPAVSRSTESFA 2899
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 154 TPPRPPQPsilqPGSQVLPPPPTTLNGPGASPLPLPMYRPDGLSGPP-PPNAQYQPPPLPGqtlGAGYPPQQANSGP-QM 231
Cdd:PHA03247 2900 LPPDQPER----PPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPlAPTTDPAGAGEPS---GAVPQPWLGALVPgRV 2972
|
250 260 270
....*....|....*....|....*....|
gi 190343021 232 AGAQLSYPGGFPGGPAQMAGPPQPQKKLDP 261
Cdd:PHA03247 2973 AVPRFRVPQPAPSREAPASSTPPLTGHSLS 3002
|
|
| dnaA |
PRK14086 |
chromosomal replication initiator protein DnaA; |
98-261 |
2.52e-07 |
|
chromosomal replication initiator protein DnaA;
Pssm-ID: 237605 [Multi-domain] Cd Length: 617 Bit Score: 54.83 E-value: 2.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 98 APYQPSAQSSYPGPISTSSVTQLGSQLSAMQINSYGSGMAPPSQGPPGPLSATSLQTPPRP----PQPSILQPGSQVLPP 173
Cdd:PRK14086 95 PAPPPPHARRTSEPELPRPGRRPYEGYGGPRADDRPPGLPRQDQLPTARPAYPAYQQRPEPgawpRAADDYGWQQQRLGF 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 174 PPTTLNGPGASPLPLPMY--------RPDGLSGPPP---PNAQYQPP-----PLPGQTLGAGYPPQQANSGPQMAGAQL- 236
Cdd:PRK14086 175 PPRAPYASPASYAPEQERdrepydagRPEYDQRRRDydhPRPDWDRPrrdrtDRPEPPPGAGHVHRGGPGPPERDDAPVv 254
|
170 180
....*....|....*....|....*....
gi 190343021 237 ----SYPGGFPGGPAQMAGPPQPQKKLDP 261
Cdd:PRK14086 255 pirpSAPGPLAAQPAPAPGPGEPTARLNP 283
|
|
| Pro-rich |
pfam15240 |
Proline-rich protein; This family includes several eukaryotic proline-rich proteins. |
103-248 |
3.84e-07 |
|
Proline-rich protein; This family includes several eukaryotic proline-rich proteins.
Pssm-ID: 464580 [Multi-domain] Cd Length: 167 Bit Score: 51.19 E-value: 3.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 103 SAQSSYPGPISTSSVTQLGSQLSAMQINSYGSGMAPPSQGPPGPLSATSLQTPPRP--PQPSILQPGS---QVLPPPPTT 177
Cdd:pfam15240 15 SAQSSSEDVSQEDSPSLISEEEGQSQQGGQGPQGPPPGGFPPQPPASDDPPGPPPPggPQQPPPQGGKqkpQGPPPQGGP 94
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 190343021 178 LNGPGASPLPLPMYRPDGLSGPPPPNAQYQPPPLPGQTLGAGYP--PQQANSGPQMAGAQLSYPGGFPGGPAQ 248
Cdd:pfam15240 95 RPPPGKPQGPPPQGGNQQQGPPPPGKPQGPPPQGGGPPPQGGNQqgPPPPPPGNPQGPPQRPPQPGNPQGPPQ 167
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
94-258 |
9.55e-07 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 53.12 E-value: 9.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 94 ASSHAPYQPSAQSSYPGPISTSSVTQLGSQLSAMQINSYGSGMAPPSQGPPGPLSATSLQTPPRPPQPSILQPGSQVLPP 173
Cdd:pfam09770 205 AQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQ 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 174 PPTTLNGPGASPlPLPMY------RPDGLSGPPPPNAQYQPPPLPGQtlgagYPPQQANSGPQMAGAQLsypggfpgGPA 247
Cdd:pfam09770 285 AQQFHQQPPPVP-VQPTQilqnpnRLSAARVGYPQNPQPGVQPAPAH-----QAHRQQGSFGRQAPIIT--------HPQ 350
|
170
....*....|.
gi 190343021 248 QMAGPPQPQKK 258
Cdd:pfam09770 351 QLAQLSEEEKA 361
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
138-349 |
1.21e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 53.02 E-value: 1.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 138 PPSQGP---PGPLSATS-LQTPPRPPQPSILQPGSQVLPPPPTTLNGPGASPLPLPMYRPDGLSGPP---PPNAQYQPPP 210
Cdd:PHA03247 2701 PPPPPPtpePAPHALVSaTPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPapaPPAAPAAGPP 2780
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 211 -----LPGQTLGAGYPPQQANSGPQMAGAQLSYPGG---FPGGPAQMAGPPQPQKKLDPDSIPSPIQVIENDRAS--RGG 280
Cdd:PHA03247 2781 rrltrPAVASLSESRESLPSPWDPADPPAAVLAPAAalpPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSvaPGG 2860
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 281 QVYATNTRGQIPPLVTTDCMIQDQGNASPRFIRcTTYCFPCTSD-MAKQAQIPLAAVIKPFATIPSNESP 349
Cdd:PHA03247 2861 DVRRRPPSRSPAAKPAAPARPPVRRLARPAVSR-STESFALPPDqPERPPQPQAPPPPQPQPQPPPPPQP 2929
|
|
| SOBP |
pfam15279 |
Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual ... |
90-253 |
1.02e-05 |
|
Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual disability. It carries a zinc-finger of the zf-C2H2 type at the N-terminus, and a highly characteriztic C-terminal PhPhPhPhPhPh motif. The deduced 873-amino acid protein contains an N-terminal nuclear localization signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif. SOBP is expressed in various human tissues, including developing mouse brain at embryonic day 14. In postnatal and adult mouse brain SOBP is expressed in all neurons, with intense staining in the limbic system. Highest expression is in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of SOBP in the limbic system corresponds to a time of active synaptogenesis. the family is also referred to as Jackson circler, JXC1. In seven affected siblings from a consanguineous Israeli Arab family with mental retardation, anterior maxillary protrusion, and strabismus mutations were found in this protein.
Pssm-ID: 464609 [Multi-domain] Cd Length: 325 Bit Score: 48.66 E-value: 1.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 90 VNNVASSHAPYQPSAQSSYPGPISTSSVT----------QLGSQLSAMQINSYGSGMAPPSQGPPGPLSAT----SLQTP 155
Cdd:pfam15279 119 VASSSKLLAPKPHEPPSLPPPPLPPKKGRrhrpglhpplGRPPGSPPMSMTPRGLLGKPQQHPPPSPLPAFmepsSMPPP 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 156 PRPPQPSILQPGSQVLPP------PPTTLNGPGASPlPLPMYRPD-GLSGPPPPNAQYQPPPLPGQTLGAGYPPQQANSG 228
Cdd:pfam15279 199 FLRPPPSIPQPNSPLSNPmlpgigPPPKPPRNLGPP-SNPMHRPPfSPHHPPPPPTPPGPPPGLPPPPPRGFTPPFGPPF 277
|
170 180
....*....|....*....|....*
gi 190343021 229 PQMAGAQLSYPGGFPGGPAQMAGPP 253
Cdd:pfam15279 278 PPVNMMPNPPEMNFGLPSLAPLVPP 302
|
|
| Pro-rich |
pfam15240 |
Proline-rich protein; This family includes several eukaryotic proline-rich proteins. |
115-269 |
1.02e-05 |
|
Proline-rich protein; This family includes several eukaryotic proline-rich proteins.
Pssm-ID: 464580 [Multi-domain] Cd Length: 167 Bit Score: 46.95 E-value: 1.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 115 SSVTQLGSQLSAMQINSYGSGMAPPSQGPpgplsATSLQTPPRPPQPSilQPGSQVLPPPPTTLNGPGASPLPLPMYRPD 194
Cdd:pfam15240 14 SSAQSSSEDVSQEDSPSLISEEEGQSQQG-----GQGPQGPPPGGFPP--QPPASDDPPGPPPPGGPQQPPPQGGKQKPQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 195 GLSGP----PPPNAQYQPPPLPGQTLGAGYPPQQANSGPQMAGAQLSYPGGFPGGPAQMAGPPQ--PQKKLDPDSIPSPI 268
Cdd:pfam15240 87 GPPPQggprPPPGKPQGPPPQGGNQQQGPPPPGKPQGPPPQGGGPPPQGGNQQGPPPPPPGNPQgpPQRPPQPGNPQGPP 166
|
.
gi 190343021 269 Q 269
Cdd:pfam15240 167 Q 167
|
|
| MISS |
pfam15822 |
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic ... |
139-255 |
1.74e-05 |
|
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic MAPK-interacting and spindle-stabilising protein-like proteins. MISS is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localization signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII spindle. MISS is the first example of a physiological MAPK-substrate that is stabilized in MII that specifically regulates MII spindle integrity during the CSF arrest.
Pssm-ID: 318115 [Multi-domain] Cd Length: 238 Bit Score: 47.29 E-value: 1.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 139 PSQGPPGPLSATSLQTPPRPPQ--PSILQPGSQVLPPPPT----TLNGPGASPLPLPMYRPDGLSGPPPpNAQYQPPPLP 212
Cdd:pfam15822 26 PPQGWPGSNPWNNPSAPPAVPSglPPSTAPSTVPFGPAPTgmypSIPLTGPSPGPPAPFPPSGPSCPPP-GGPYPAPTVP 104
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 190343021 213 GQTLGAGYPPqqansgPQMAGAQLSYPGGFPGGPAQmAGPPQP 255
Cdd:pfam15822 105 GPGPIGPYPT------PNMPFPELPRPYGAPTDPAA-AAPSGP 140
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
30-284 |
1.94e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 48.83 E-value: 1.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 30 GDPSHTASPTGMMKPAGPLGATATRGMLPPGPPPPGPHQFGQNGAHAtghppqrfpgpppvnnvasshapyqPSAQSSYP 109
Cdd:PRK07764 589 GPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAA-------------------------PAEASAAP 643
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 110 GPISTSSVTQLGSqlSAMQINSYGSGMAPPSQGPPGPLSATSLQTPPRPPQPSILQPGSQVLPPPPTTLNGPGASPLPLP 189
Cdd:PRK07764 644 APGVAAPEHHPKH--VAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQP 721
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 190 MYRPDGLSGPPPPNAQYQPPPlpgqtLGAGYPPQQANSGPQMAGAQLSYPGGFPGGPAQMAGPPQPQKKLDPDsIPSPiq 269
Cdd:PRK07764 722 PQAAQGASAPSPAADDPVPLP-----PEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDD-APSM-- 793
|
250
....*....|....*
gi 190343021 270 vieNDRASRGGQVYA 284
Cdd:PRK07764 794 ---DDEDRRDAEEVA 805
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
86-267 |
2.24e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 48.78 E-value: 2.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 86 GPPPVNNVASSHAPYQPSA--------QSSYPGPISTSSVTQLGSQLSAMQINSYGSGMAPPSQGPP----GPLSATSLQ 153
Cdd:PHA03247 2598 PRAPVDDRGDPRGPAPPSPlppdthapDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPrrarRLGRAAQAS 2677
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 154 TPPRPPQPSILQPGSQVL-------PPPPTTLNGPGA--SPLPLPMYRPDGLSGPPPPNAQYQPPPLPGQTLGAGYPPQQ 224
Cdd:PHA03247 2678 SPPQRPRRRAARPTVGSLtsladppPPPPTPEPAPHAlvSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARP 2757
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 190343021 225 AnSGPQMAGAQLSYPGGFPGGPAQMAGPPQPQKKLDP--DSIPSP 267
Cdd:PHA03247 2758 A-RPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSEsrESLPSP 2801
|
|
| PRK13729 |
PRK13729 |
conjugal transfer pilus assembly protein TraB; Provisional |
117-214 |
2.35e-05 |
|
conjugal transfer pilus assembly protein TraB; Provisional
Pssm-ID: 184281 [Multi-domain] Cd Length: 475 Bit Score: 48.28 E-value: 2.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 117 VTQLGSQLSAMQINSYGSGMAPP-SQGPPGPLSATSLQTPPRPPQPSilqPGSQVLPPppttlNGPGASPLPLPMYrpDG 195
Cdd:PRK13729 106 IEKLGQDNAALAEQVKALGANPVtATGEPVPQMPASPPGPEGEPQPG---NTPVSFPP-----QGSVAVPPPTAFY--PG 175
|
90
....*....|....*....
gi 190343021 196 LSGPPPPNAQYQPPPLPGQ 214
Cdd:PRK13729 176 NGVTPPPQVTYQSVPVPNR 194
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
137-280 |
2.56e-05 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 48.63 E-value: 2.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 137 APPSQGPPGPLSATSLQTPPRPPQPsilqpgsqVLPPPPTtlnGPGASPLPLPMYRPDGLSGPPPPNAQYQPPPLPGQTL 216
Cdd:PHA03307 99 SPAREGSPTPPGPSSPDPPPPTPPP--------ASPPPSP---APDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAA 167
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 190343021 217 GAGYPPQQANSGPQMAGAQLSYPGGFPGGPAQMAGPPQPQKKLDPDSIPSPIQVIENDRASRGG 280
Cdd:PHA03307 168 SSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADD 231
|
|
| FAP |
pfam07174 |
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment ... |
137-230 |
2.99e-05 |
|
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix.
Pssm-ID: 429334 Cd Length: 301 Bit Score: 47.23 E-value: 2.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 137 APPSQGPPGPLSATSLQTPPRPPQPsilqPGSQVLPPPPTTLNGPGASPlplpmyrpdglsGPPPPNAQYQPPPLPgqtl 216
Cdd:pfam07174 39 ADPEPAPPPPSTATAPPAPPPPPPA----PAAPAPPPPPAAPNAPNAPP------------PPADPNAPPPPPADP---- 98
|
90
....*....|....
gi 190343021 217 GAGYPPQQANSGPQ 230
Cdd:pfam07174 99 NAPPPPAVDPNAPE 112
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
134-293 |
3.27e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 47.95 E-value: 3.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 134 SGMAPPSQGPPGPLSATSLQTPPRPPQPSILQPGSQVLPPPPTTLNGPGA---SPLPLPMYRPDGLSGPPPPNAqyqPPP 210
Cdd:PRK12323 376 TAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARrspAPEALAAARQASARGPGGAPA---PAP 452
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 211 LPGQTLGAGYPPQQANSGPQMAGAQLSYPGGFPGGPAQMAGPPQPQKKLDPDSIPSPiQVIENDRASRGGQVYATNTRGQ 290
Cdd:PRK12323 453 APAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASP-APAQPDAAPAGWVAESIPDPAT 531
|
...
gi 190343021 291 IPP 293
Cdd:PRK12323 532 ADP 534
|
|
| Med15 |
pfam09606 |
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ... |
123-256 |
3.98e-05 |
|
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.
Pssm-ID: 312941 [Multi-domain] Cd Length: 732 Bit Score: 47.70 E-value: 3.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 123 QLSAMQINSYGSGMAPPSQGPPGPLSAtsLQTPP----RPPQPSILQPGSQvlPPPPTTLNGPG-ASPLPLPMYRPD--- 194
Cdd:pfam09606 59 QQQQPQGGQGNGGMGGGQQGMPDPINA--LQNLAgqgtRPQMMGPMGPGPG--GPMGQQMGGPGtASNLLASLGRPQmpm 134
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 190343021 195 -GLSGPPPPNA--QYQP----PPLPGQTLGAGYPPQQANSGPQMAGAQLSYPGGFPGGPAQMAGPPQPQ 256
Cdd:pfam09606 135 gGAGFPSQMSRvgRMQPggqaGGMMQPSSGQPGSGTPNQMGPNGGPGQGQAGGMNGGQQGPMGGQMPPQ 203
|
|
| dnaA |
PRK14086 |
chromosomal replication initiator protein DnaA; |
139-280 |
4.35e-05 |
|
chromosomal replication initiator protein DnaA;
Pssm-ID: 237605 [Multi-domain] Cd Length: 617 Bit Score: 47.51 E-value: 4.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 139 PSQGPPGPLSatslQTPPRPPQPSILQPGSQvlppPPTTLNGPGASPLPLPMYRPDGLSGPPPPNAQYQPPPLPGQtlga 218
Cdd:PRK14086 90 PSAGEPAPPP----PHARRTSEPELPRPGRR----PYEGYGGPRADDRPPGLPRQDQLPTARPAYPAYQQRPEPGA---- 157
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 190343021 219 gYPPQQANSGPQMAgaqlsyPGGFPgGPAQMAGPPQPQKKLDPDSIPSPIQVIENDRASRGG 280
Cdd:PRK14086 158 -WPRAADDYGWQQQ------RLGFP-PRAPYASPASYAPEQERDREPYDAGRPEYDQRRRDY 211
|
|
| Med15 |
pfam09606 |
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ... |
148-295 |
6.09e-05 |
|
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.
Pssm-ID: 312941 [Multi-domain] Cd Length: 732 Bit Score: 46.93 E-value: 6.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 148 SATSLQTPPRPPQPSILQPGSQVLPPPPTTL-NGPGASPLPlPMYRPDGLSGPPPPNAQYQPPPLPGQTLGAGYPPQQAN 226
Cdd:pfam09606 56 KAAQQQQPQGGQGNGGMGGGQQGMPDPINALqNLAGQGTRP-QMMGPMGPGPGGPMGQQMGGPGTASNLLASLGRPQMPM 134
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 190343021 227 SGPQMAGAQLSYPGGFPGGpaQMAGPPQPQKKLDPDSIPspiQVIENDRASRGGQVYATNTRGQIPPLV 295
Cdd:pfam09606 135 GGAGFPSQMSRVGRMQPGG--QAGGMMQPSSGQPGSGTP---NQMGPNGGPGQGQAGGMNGGQQGPMGG 198
|
|
| BimA_second |
NF040983 |
trimeric autotransporter actin-nucleating factor BimA; This HMM describes BimA (Burkholderia ... |
143-246 |
6.58e-05 |
|
trimeric autotransporter actin-nucleating factor BimA; This HMM describes BimA (Burkholderia intracellular motility A), WP_004266405.1-like proteins in Burkholderia mallei or B. pseudomallei. The term BimA has also been used for WP_011205626.1-like homologs that have a very different N-terminal half.
Pssm-ID: 468913 [Multi-domain] Cd Length: 382 Bit Score: 46.43 E-value: 6.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 143 PPGPLSATSLQTPPRPPQPSilqpgsqvlPPPPTTLNGPGASPLPLPmyrPDGLSGPPPPNAQYQPPPLPGQTLGAGYPP 222
Cdd:NF040983 79 PVGDRTLPNKVPPPPPPPPP---------PPPPPPTPPPPPPPPPPP---PPPSPPPPPPPSPPPSPPPPTTTPPTRTTP 146
|
90 100
....*....|....*....|....
gi 190343021 223 QQANSGPQMAGAQlsyPGGFPGGP 246
Cdd:NF040983 147 STTTPTPSMHPIQ---PTQLPSIP 167
|
|
| DUF3729 |
pfam12526 |
Protein of unknown function (DUF3729); This family of proteins is found in viruses. Proteins ... |
136-221 |
7.11e-05 |
|
Protein of unknown function (DUF3729); This family of proteins is found in viruses. Proteins in this family are typically between 145 and 1707 amino acids in length. The family is found in association with pfam01443, pfam01661, pfam05417, pfam01660, pfam00978. There is a single completely conserved residue L that may be functionally important.
Pssm-ID: 372164 [Multi-domain] Cd Length: 115 Bit Score: 43.14 E-value: 7.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 136 MAPPSQGPPGPLSATSLQTPPRPPQPSilqPGSQVLPPPPTTLNGPGASPLPLPMYRPDGLSGPPppnaqyQPPPLPGQT 215
Cdd:pfam12526 39 PPPPVGDPRPPVVDTPPPVSAVWVLPP---PSEPAAPEPDLVPPVTGPAGPPSPLAPPAPAQKPP------LPPPRPQRR 109
|
....*.
gi 190343021 216 LGAGYP 221
Cdd:pfam12526 110 LLHTYP 115
|
|
| PRK13729 |
PRK13729 |
conjugal transfer pilus assembly protein TraB; Provisional |
181-256 |
1.10e-04 |
|
conjugal transfer pilus assembly protein TraB; Provisional
Pssm-ID: 184281 [Multi-domain] Cd Length: 475 Bit Score: 45.97 E-value: 1.10e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 190343021 181 PGASP-LPLPMYRPDGLSGPPPPNAQYQPPPLPgqtlgAGYPPQQANSGPQMAGAqlsYPGGFPGGPAQMAGPPQPQ 256
Cdd:PRK13729 123 LGANPvTATGEPVPQMPASPPGPEGEPQPGNTP-----VSFPPQGSVAVPPPTAF---YPGNGVTPPPQVTYQSVPV 191
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
94-267 |
1.21e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 46.02 E-value: 1.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 94 ASSHAPYQPSAQSSYPGPISTSSVTQLGSQLSAMQINSYGSGMAPPSQGPPGPLSATSLQTPPRPPQPSILQPGSQVLPP 173
Cdd:PRK12323 400 AAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAA 479
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 174 PPttLNGPGASPLPLPMYRPDGLSGPPPPnaqyqPPPLPGQTlGAGYPPQQANSGPQMAGAQLSYPggFPGGPAQMAGPP 253
Cdd:PRK12323 480 PA--RAAPAAAPAPADDDPPPWEELPPEF-----ASPAPAQP-DAAPAGWVAESIPDPATADPDDA--FETLAPAPAAAP 549
|
170
....*....|....
gi 190343021 254 QPQKKLDPDSIPSP 267
Cdd:PRK12323 550 APRAAAATEPVVAP 563
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
137-241 |
1.21e-04 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 46.13 E-value: 1.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 137 APPSQGPPGPLSATSLQTPPRPPQPSILQPGSQVLPPPPTtlnGPGASPLPLPMYRPDGLSGPPPPNAQYQPPPLPGQTL 216
Cdd:PRK07764 404 AAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPS---PAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAP 480
|
90 100
....*....|....*....|....*
gi 190343021 217 GAGYPPQQANSGPQMAGAQLSYPGG 241
Cdd:PRK07764 481 APAPPAAPAPAAAPAAPAAPAAPAG 505
|
|
| PABP-1234 |
TIGR01628 |
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ... |
102-231 |
1.22e-04 |
|
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.
Pssm-ID: 130689 [Multi-domain] Cd Length: 562 Bit Score: 45.95 E-value: 1.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 102 PSAQSSYPGPISTS-SVTQLGSQLSAMQINSY-----GSGMAPPSQGppgplsatslqtPPRPPQPSILQPGSQVLPPPP 175
Cdd:TIGR01628 381 RMRQLPMGSPMGGAmGQPPYYGQGPQQQFNGQplgwpRMSMMPTPMG------------PGGPLRPNGLAPMNAVRAPSR 448
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 190343021 176 TTLNGPGASPLPLPMYRPDGLSGPPPPNAQyQPPPLPGQTLGAGYPPQQ-ANSGPQM 231
Cdd:TIGR01628 449 NAQNAAQKPPMQPVMYPPNYQSLPLSQDLP-QPQSTASQGGQNKKLAQVlASATPQM 504
|
|
| PHA03379 |
PHA03379 |
EBNA-3A; Provisional |
98-332 |
1.24e-04 |
|
EBNA-3A; Provisional
Pssm-ID: 223066 [Multi-domain] Cd Length: 935 Bit Score: 46.20 E-value: 1.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 98 APYQPSAQSSYPGPISTSSVTQLGSQlsamqinsygSGMAP--PSQGPPGPLSATSL--QTP-----PRP-PQPSILQPG 167
Cdd:PHA03379 434 ATSHGSAQVPEPPPVHDLEPGPLHDQ----------HSMAPcpVAQLPPGPLQDLEPgdQLPgvvqdGRPaCAPVPAPAG 503
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 168 SQVLPPPPTTLNGPGASPLPlpmYRPDGLSGP--PPPNAQYQPPPLPGQTLGAGYPPQQANSGPQmagAQLSYpggfpGG 245
Cdd:PHA03379 504 PIVRPWEASLSQVPGVAFAP---VMPQPMPVEpvPVPTVALERPVCPAPPLIAMQGPGETSGIVR---VRERW-----RP 572
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 246 PAQMAGPPQPqkkldpdsiPSPIQVieNDRASRG---GQVYATNTRGQIPPLVTTDCMIQDQGNASPRFIRCTTYCFPCT 322
Cdd:PHA03379 573 APWTPNPPRS---------PSQMSV--RDRLARLraeAQPYQASVEVQPPQLTQVSPQQPMEYPLEPEQQMFPGSPFSQV 641
|
250
....*....|
gi 190343021 323 SDMAKQAQIP 332
Cdd:PHA03379 642 ADVMRAGGVP 651
|
|
| PBP1 |
COG5180 |
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ... |
99-275 |
1.95e-04 |
|
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];
Pssm-ID: 444064 [Multi-domain] Cd Length: 548 Bit Score: 45.44 E-value: 1.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 99 PYQPSAQSSyPGPISTSSvtqlgSQLSAMQINSYGSGMAPPSQGPPGPLSATSLQTPPRPPQ------------------ 160
Cdd:COG5180 278 PGLPVLEAG-SEPQSDAP-----EAETARPIDVKGVASAPPATRPVRPPGGARDPGTPRPGQpterpagvpeaasdagqp 351
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 161 PSILQPGSQVLP--------PPPTTLNGPGASPLPLPMYRPDGLSGPPPPNAqyqPPPLPGQTLGAGYPPQQANSGPQMA 232
Cdd:COG5180 352 PSAYPPAEEAVPgkpleqgaPRPGSSGGDGAPFQPPNGAPQPGLGRRGAPGP---PMGAGDLVQAALDGGGRETASLGGA 428
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 190343021 233 GAQLSYPGGFPGGPAQMAGPPQPQKKLDPDSIPSPIQVIENDR 275
Cdd:COG5180 429 AGGAGQGPKADFVPGDAESVSGPAGLADQAGAAASTAMADFVA 471
|
|
| COG3416 |
COG3416 |
Uncharacterized conserved protein, DUF2076 domain [Function unknown]; |
117-250 |
2.01e-04 |
|
Uncharacterized conserved protein, DUF2076 domain [Function unknown];
Pssm-ID: 442642 [Multi-domain] Cd Length: 237 Bit Score: 44.24 E-value: 2.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 117 VTQLGSQLSAMQinsygsgmAPPSQGPPGPLSATSLQTPPRPPQPSILQPGSQVLPPPPttlngpgasplplpmyrpdgl 196
Cdd:COG3416 64 IQELEAQLAQLQ--------QQQPQSSGGFLSGLFGGGQRPPPAPQPSQPGPQQQPAPP--------------------- 114
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 190343021 197 sgPPPPNAQYQPPPlpgqtlGAGYPPQQAnsgPQMAGAQlsyPGGFPGGPAQMA 250
Cdd:COG3416 115 --SGPWGQAAPQQP------GYGQPQYGQ---PAAGPSG---GGGFLGGALQTA 154
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
132-264 |
2.05e-04 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 45.36 E-value: 2.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 132 YGSGMAPPSQGPPGPLSATslqTPPRPPQPSILQPGSQVLPPPPTTLNGPGASPLPlpmyRPDGLSGPPPPNAQYQPPPL 211
Cdd:PRK07764 387 VAGGAGAPAAAAPSAAAAA---PAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAP----APPSPAGNAPAGGAPSPPPA 459
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 190343021 212 PGQTLGAGYPPQQANSGPQMAGAQLSYPGGFPGGPAQMAGPPQPQKKLDPDSI 264
Cdd:PRK07764 460 AAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATL 512
|
|
| Med25_SD1 |
pfam11235 |
Mediator complex subunit 25 synapsin 1; The overall function of the full-length Med25 is ... |
102-248 |
2.20e-04 |
|
Mediator complex subunit 25 synapsin 1; The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA, domain, this SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This The function of the SD domains is unclear.
Pssm-ID: 463244 [Multi-domain] Cd Length: 157 Bit Score: 42.85 E-value: 2.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 102 PSAQSSYPGPISTSSVTQL------GSQLSAMQINSYGSgmAPPSQGPPGPLSATSL--QTPPRPPQPSILQPGSQVLPP 173
Cdd:pfam11235 2 PVGGGSAPGPLQSKQPVPLppaapsGATLSAAPQQPLPP--VPPQYQVPGNLSAAQVaaQNAVEAAKNQKAGLGPRFSPI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 174 PPTTLNGPGASPlplPMYRPDGLSGPP-PPNAQYQPPPLPGQTL------GAGYPPQQANSGPQMAGAqlSYPGGFPG-G 245
Cdd:pfam11235 80 TPLQQAAPGVGP---PFSQAPAPQLPPgPPGAPKPVPPASQPSLvstvapGSGLAPTAQPGAPSMAGT--VAPGGVSGpS 154
|
...
gi 190343021 246 PAQ 248
Cdd:pfam11235 155 PAQ 157
|
|
| Drf_FH1 |
pfam06346 |
Formin Homology Region 1; This region is found in some of the Diaphanous related formins (Drfs) ... |
143-212 |
2.41e-04 |
|
Formin Homology Region 1; This region is found in some of the Diaphanous related formins (Drfs). It consists of low complexity repeats of around 12 residues.
Pssm-ID: 461881 [Multi-domain] Cd Length: 157 Bit Score: 42.55 E-value: 2.41e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 143 PPGPLSATSLQTPPRPPQPsilqpGSQVLPPPPTTLngPGASPLPLPMYRPDGLSGPPPPNAQYQPPPLP 212
Cdd:pfam06346 83 PPPPLPGGAGIPPPPPPLP-----GGAGVPPPPPPL--PGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPP 145
|
|
| BimA_first |
NF040984 |
trimeric autotransporter actin-nucleating factor BimA; BimA (B. pseudomallei intracellular ... |
94-211 |
2.45e-04 |
|
trimeric autotransporter actin-nucleating factor BimA; BimA (B. pseudomallei intracellular motility protein A) is a trimeric autotransporter, homologous in its C-terminal half to a number of trimeric autotransporter adhesins. It is a virulence factor that nucleates actin, so that actin polymerization can drive escape by B. pseudomallei out of one cell and into a neighboring cell. HMM NF040983 describes a homolog with similar activity but substantial difference in sequence architecture in the N-terminal region.
Pssm-ID: 468914 [Multi-domain] Cd Length: 517 Bit Score: 44.86 E-value: 2.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 94 ASSHAPYQPSaqssyPGPISTSSVTQLGSQLSAMQINSYGSgmappsqgPPGPLSATSLQTPPrpPQPSilqPGSQVLPP 173
Cdd:NF040984 6 SSSHAPDAPK-----PSSIATTLCRALASLSLGLSMDAEAN--------PPEPPGGTNIPVPP--PMPG---GGANIPVP 67
|
90 100 110
....*....|....*....|....*....|....*...
gi 190343021 174 PPTTLNGPGASPLPLPmyrPDGLSGPPPpnaqyQPPPL 211
Cdd:NF040984 68 PPMPGGGANIPPPPPP---PGGIGGATP-----SPPPL 97
|
|
| DUF3824 |
pfam12868 |
Domain of unknwon function (DUF3824); This is a repeating domain found in fungal proteins. It ... |
172-255 |
3.25e-04 |
|
Domain of unknwon function (DUF3824); This is a repeating domain found in fungal proteins. It is proline-rich, and the function is not known.
Pssm-ID: 372351 [Multi-domain] Cd Length: 145 Bit Score: 42.04 E-value: 3.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 172 PPPPTtlnGPGASPLPlpmYRPDGLSGPPPPNAqYQPPPLPGQTLGAGYPPQQANSGPQMAGAQLSYPGGFPGGPAQMAG 251
Cdd:pfam12868 62 PPSPA---GPYASQGQ---YYPETNYFPPPPGS-TPQPPVDPQPNAPPPPYNPADYPPPPGAAPPPQPYQYPPPPGPDPY 134
|
....
gi 190343021 252 PPQP 255
Cdd:pfam12868 135 APRP 138
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
137-293 |
3.84e-04 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 44.59 E-value: 3.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 137 APPSQGPPGPLSATSLQTPPRPPQPSILQPGSQVLPPPPTtlngPGASPLPLPMYRPDG---LSGPPPPNAQYQPPPLPG 213
Cdd:PRK07764 614 RPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHH----PKHVAVPDASDGGDGwpaKAGGAAPAAPPPAPAPAA 689
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 214 QTLGAGYPPQQANSGP--QMAGAQLSYPGGFPGGPAQMAG----------PPQPQKKLDPDSIPSPIQVIENDRASRGGQ 281
Cdd:PRK07764 690 PAAPAGAAPAQPAPAPaaTPPAGQADDPAAQPPQAAQGASapspaaddpvPLPPEPDDPPDPAGAPAQPPPPPAPAPAAA 769
|
170
....*....|..
gi 190343021 282 VYATNTRGQIPP 293
Cdd:PRK07764 770 PAAAPPPSPPSE 781
|
|
| PRK14971 |
PRK14971 |
DNA polymerase III subunit gamma/tau; |
121-228 |
5.93e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237874 [Multi-domain] Cd Length: 614 Bit Score: 43.61 E-value: 5.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 121 GSQLSAMQINSYGSGMAPPSQGPPGPLSATSLQTPPRPPQPSILQPGSQVLP-PPPTTLNGPGASPLPLPMYRPDglSGP 199
Cdd:PRK14971 371 GGRGPKQHIKPVFTQPAAAPQPSAAAAASPSPSQSSAAAQPSAPQSATQPAGtPPTVSVDPPAAVPVNPPSTAPQ--AVR 448
|
90 100 110
....*....|....*....|....*....|....*
gi 190343021 200 PPPNAQYQPPPLPGQ------TLGAGYPPQQANSG 228
Cdd:PRK14971 449 PAQFKEEKKIPVSKVsslgpsTLRPIQEKAEQATG 483
|
|
| DUF3729 |
pfam12526 |
Protein of unknown function (DUF3729); This family of proteins is found in viruses. Proteins ... |
139-214 |
7.12e-04 |
|
Protein of unknown function (DUF3729); This family of proteins is found in viruses. Proteins in this family are typically between 145 and 1707 amino acids in length. The family is found in association with pfam01443, pfam01661, pfam05417, pfam01660, pfam00978. There is a single completely conserved residue L that may be functionally important.
Pssm-ID: 372164 [Multi-domain] Cd Length: 115 Bit Score: 40.45 E-value: 7.12e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 190343021 139 PSQGPPGPLSATSLQTPPRPPQPSILQPGSQVLPPPPTTLNGPGASPLPLPMYRPDGLSGPPPPNAQYQPPPLPGQ 214
Cdd:pfam12526 29 FSPPESAHPDPPPPVGDPRPPVVDTPPPVSAVWVLPPPSEPAAPEPDLVPPVTGPAGPPSPLAPPAPAQKPPLPPP 104
|
|
| ARS2 |
pfam04959 |
Arsenite-resistance protein 2; Arsenite is a carcinogenic compound which can act as a ... |
152-246 |
7.17e-04 |
|
Arsenite-resistance protein 2; Arsenite is a carcinogenic compound which can act as a co-mutagen by inhibiting DNA repair. Arsenite-resistance protein 2 is thought to play a role in arsenite resistance.
Pssm-ID: 461498 Cd Length: 195 Bit Score: 41.79 E-value: 7.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 152 LQTPPRPPQPSiLQPgsqvlPPPPTTLNGPGASPLPLPMYRPDGLSGppppnAQYQPPPLPGQTLGAGYPPQQANSGPQM 231
Cdd:pfam04959 109 LADAKRPATPE-LKP-----KPPPRPANRRERPGRAFPSQRPQGQMS-----DGHPRPPMDGPGGGPPFPPNQYGGGRGN 177
|
90
....*....|....*.
gi 190343021 232 AGA-QLSYPGGFPGGP 246
Cdd:pfam04959 178 YDNfRGQGGGGYPPKP 193
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
94-293 |
7.88e-04 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 43.49 E-value: 7.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 94 ASSHAPYQPsAQSSY-----PGPIS----TSSVTQLGSQLSAMQINSYGSGMAPPSQGPPGP--LS------ATSLQTPP 156
Cdd:pfam09770 131 QQSQQPSKP-VRTGYekykePEPIPdlqvDASLWGVAPKKAAAPAPAPQPAAQPASLPAPSRkmMSleeveaAMRAQAKK 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 157 RPPQPSILQPGSQVLPPPPttlngpgasplplpmyrpdglSGPPPPNAQYQPPPLPGQTLGAGYPPQQANSGPQMagAQL 236
Cdd:pfam09770 210 PAQQPAPAPAQPPAAPPAQ---------------------QAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPV--TIL 266
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 237 SYPGGFPGGPAQMAGPPQPQ--KKLDPDSIPSPIQVIEN-DRASRGGQVYATNTRGQIPP 293
Cdd:pfam09770 267 QRPQSPQPDPAQPSIQPQAQqfHQQPPPVPVQPTQILQNpNRLSAARVGYPQNPQPGVQP 326
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
93-217 |
1.06e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 42.78 E-value: 1.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 93 VASSHAPYQPSAQSSYPGPIStssVTQLGSQLSAMQINSYGSGMAPPSQGPPGPLSATSLQTPPRPPQPsilqpGSQVLP 172
Cdd:PRK14951 375 PAEKKTPARPEAAAPAAAPVA---QAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAA-----APAAVA 446
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 190343021 173 PPPTTLNGPGASPLPLPMY---RPDGLSGPPPPNAQYQPPPLPGQTLG 217
Cdd:PRK14951 447 LAPAPPAQAAPETVAIPVRvapEPAVASAAPAPAAAPAAARLTPTEEG 494
|
|
| Prog_receptor |
pfam02161 |
Progesterone receptor; |
99-200 |
1.74e-03 |
|
Progesterone receptor;
Pssm-ID: 460470 Cd Length: 564 Bit Score: 42.22 E-value: 1.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 99 PYQPSAQSSYPGPIS------TSSVTQLGSQLSAMQINSYGSGMAPPSQGPPGPLsatslqtPPRPPQPSILQPGSQVLP 172
Cdd:pfam02161 424 PLPPRAPSSRPGEAAvaaapaSASVSSASSSGSTLECILYKAEGAPPQQGPFAPP-------PCKPPGAGACLLPRDGLP 496
|
90 100
....*....|....*....|....*...
gi 190343021 173 PPPTTLNGPGASPlplPMYRPDGLSGPP 200
Cdd:pfam02161 497 STSASAAAAGAAP---ALYPPLGLNGLP 521
|
|
| PHA03264 |
PHA03264 |
envelope glycoprotein D; Provisional |
172-265 |
1.89e-03 |
|
envelope glycoprotein D; Provisional
Pssm-ID: 223029 [Multi-domain] Cd Length: 416 Bit Score: 41.91 E-value: 1.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 172 PPPPTTLNGPGASPLPLPMYRPDGLSGPPPPNAQ--YQPPPLPGQTLGAGYPPQQANSGPQMAGAQLSYPGGFPGGPAQM 249
Cdd:PHA03264 266 PPPAPSGGSPAPPGDDRPEAKPEPGPVEDGAPGRetGGEGEGPEPAGRDGAAGGEPKPGPPRPAPDADRPEGWPSLEAIT 345
|
90
....*....|....*.
gi 190343021 250 AGPPQPQKKLDPDSIP 265
Cdd:PHA03264 346 FPPPTPATPAVPRARP 361
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
137-236 |
2.47e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 41.90 E-value: 2.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 137 APPSQGPPGPLSATSLQTPPRPPQPSILQPGSQVLPPPPTTLNGPGASPLPLPM----YRPDGLSGPPPPNAQYQPPPLP 212
Cdd:PRK07764 416 APAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPApaaaPEPTAAPAPAPPAAPAPAAAPA 495
|
90 100
....*....|....*....|....
gi 190343021 213 GQTLGAGYPPQQANSGPQMAGAQL 236
Cdd:PRK07764 496 APAAPAAPAGADDAATLRERWPEI 519
|
|
| Gag_spuma |
pfam03276 |
Spumavirus gag protein; |
134-271 |
3.22e-03 |
|
Spumavirus gag protein;
Pssm-ID: 460872 [Multi-domain] Cd Length: 614 Bit Score: 41.27 E-value: 3.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 134 SGMAPPSQGPPGPLSATSlqtppRPPQPSILQPGSQVLPPPPTTLNGPGASPLPLPMYRPDGLSGPPPPNAQYQPPPLPG 213
Cdd:pfam03276 176 AEISPGAQGGIPPGASFS-----GLPSLPAIGGIHLPAIPGIHARAPPGNIARSLGDDIMPSLGDAGMPQPRFAFHPGNP 250
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 190343021 214 QTLGAGYPPQQAnSGPQMAGAQLSYPGGFPGGPAQMAGPPQPQKKLDPDSIPSPIQVI 271
Cdd:pfam03276 251 FAEAEGHPFAEA-EGERPRDIPRAPRIDAPSAPAIPAIQPIAPPMIPPIGAPIPIPHG 307
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
137-210 |
4.07e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 41.46 E-value: 4.07e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 190343021 137 APPSQGPPGPLSATSLQTPPRPPQPSIlqpgsqvlPPPPTTLNGPGASPL----PLPMYRPDGLSGPPPPNAQYQPPP 210
Cdd:PHA03247 388 ARHAATPFARGPGGDDQTRPAAPVPAS--------VPTPAPTPVPASAPPppatPLPSAEPGSDDGPAPPPERQPPAP 457
|
|
| Med15 |
pfam09606 |
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ... |
3-240 |
4.19e-03 |
|
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.
Pssm-ID: 312941 [Multi-domain] Cd Length: 732 Bit Score: 41.15 E-value: 4.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 3 QQGYVATPPYSQPQPGIGLSPPHYGHYGDPShtASPTGMmkPAGPLGATATR-----------GMLPPGPPPPGPHQFGQ 71
Cdd:pfam09606 243 MQQQQPQQQGQQSQLGMGINQMQQMPQGVGG--GAGQGG--PGQPMGPPGQQpgampnvmsigDQNNYQQQQTRQQQQQQ 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 72 NGAHATGHPPQRFPGPPPVNNVASshAPYQPSAQSSYPGPISTSSVTQLGSQLSAMqinsygsgMAPPSQGPPGPL-SAT 150
Cdd:pfam09606 319 GGNHPAAHQQQMNQSVGQGGQVVA--LGGLNHLETWNPGNFGGLGANPMQRGQPGM--------MSSPSPVPGQQVrQVT 388
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 151 SLQTPPRPPQPSILQPGsqvlppppttlnGPGASPLPLPMYRPdglsgPPPPNAQYQPPPLPGQTlgagyPPQQANSGPQ 230
Cdd:pfam09606 389 PNQFMRQSPQPSVPSPQ------------GPGSQPPQSHPGGM-----IPSPALIPSPSPQMSQQ-----PAQQRTIGQD 446
|
250
....*....|
gi 190343021 231 MAGAQLSYPG 240
Cdd:pfam09606 447 SPGGSLNTPG 456
|
|
| SP6_N |
cd22544 |
N-terminal domain of transcription factor Specificity Protein (SP) 6; Specificity Proteins ... |
114-253 |
4.44e-03 |
|
N-terminal domain of transcription factor Specificity Protein (SP) 6; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP6, also known as epiprofin, shows specific expression pattern in hair follicles and the apical ectodermal ridge (AER) of the developing limbs. SP6 null mice are nude and show defects in skin, teeth, limbs (syndactyly and oligodactyly), and lung alveoli. SP6 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. This model represents the N-terminal domain of SP6.
Pssm-ID: 411693 [Multi-domain] Cd Length: 245 Bit Score: 39.90 E-value: 4.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 114 TSSVTQLGSQLSAMQINSYGSGMAPPSQ-----------GPPGPLSATSLQTPPRPPQPSILQPGSQVlPPPPTTLNGPG 182
Cdd:cd22544 3 TAVCGSLGNQHSETPRASPPTLDLQPLQpyqihsspeagDYPSPLQPTELQSLPLGPGVDFSARESYE-PHSSRRTCLDL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 183 ASPLPLPMYRPdgLSGPPPPNAQ-YQP---PPLPGQTLGAG-----------------YPPQQANSGPQMAGAQLSYPGG 241
Cdd:cd22544 82 ESDLPLGPFPK--LLHPPPDMAHpYESwfrPPHPGGSGEEGgvpswwdlhagsswmdlQHGQGGLQSPGPPGGLQPPLGG 159
|
170
....*....|..
gi 190343021 242 FpGGPAQMAGPP 253
Cdd:cd22544 160 Y-GSEHQLCGPP 170
|
|
| SAV_2336_NTERM |
NF041121 |
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ... |
138-205 |
5.36e-03 |
|
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.
Pssm-ID: 469044 [Multi-domain] Cd Length: 473 Bit Score: 40.37 E-value: 5.36e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 190343021 138 PPSQGPPGPLSATSLQTPPRPPQPSILQPGSQVLPPPPTTLNGPGASPLPLPMYRPDglsGPPPPNAQ 205
Cdd:NF041121 39 PPPAAPPSPPGDPPEPPAPEPAPLPAPYPGSLAPPPPPPPGPAGAAPGAALPVRVPA---PPALPNPL 103
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
132-267 |
6.44e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 40.54 E-value: 6.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 132 YGS-GMAPPSQGP---PGPLSATSLQTPPRPPQ-----PSILQPGSQVLPPPPTTLNGPGASPLPLPMYRPDGLSGPPPP 202
Cdd:PHA03307 37 SGSqGQLVSDSAElaaVTVVAGAAACDRFEPPTgpppgPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDP 116
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 190343021 203 NAQYQPPPLPGQTLGAGYPPQQANSGPQMAGAQLSYPGGFPGGPAQMAGPPQPQKKLDPDSIPSP 267
Cdd:PHA03307 117 PPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEE 181
|
|
| SSDP |
pfam04503 |
Single-stranded DNA binding protein, SSDP; This is a family of eukaryotic single-stranded DNA ... |
87-255 |
7.09e-03 |
|
Single-stranded DNA binding protein, SSDP; This is a family of eukaryotic single-stranded DNA binding proteins with specificity to a pyrimidine-rich element found in the promoter region of the alpha2(I) collagen gene.
Pssm-ID: 461334 [Multi-domain] Cd Length: 293 Bit Score: 39.55 E-value: 7.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 87 PPPVNNVASSHAPYQPSAQSSYP-GPISTSSVTQLGSQLSamqinsygsgmAPPSQGPPGPLSAtslqTPPRPPQPSILQ 165
Cdd:pfam04503 61 PPPHNPATMMGPHSQPFMGPRYPgGPRPSVRMPQQGNDFN-----------GPPGQQPMMPNSM----DPTRPGGHPNMG 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 166 PGSQVLPPPpttlNGPGASPLPLPMYRPdGLSGpPPPNAQYQPPPLPGQTLGAGYPPQQANSGpqmAGAQLSYPGGFPG- 244
Cdd:pfam04503 126 GPMQRMNPP----RGPGMGPMGPQSYGP-GMRG-PPPNSTDGPGGMPPMNMGPGGRRPWPQPN---ASNPLPYSSSSPGs 196
|
170
....*....|...
gi 190343021 245 --GPAQMAGPPQP 255
Cdd:pfam04503 197 ygGPPGGGGPPGP 209
|
|
| SAV_2336_NTERM |
NF041121 |
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 ... |
137-214 |
7.43e-03 |
|
SAV_2336 family N-terminal domain; This HMM describes an N-terminal domain shared by SAV_2336 (BAC70047.1) whose C-terminal region suggests restriction enzyme activity (PMID: 18456708), and with other proteins with unrelated C-terminal regions. A member protein was also identified in a kanamycin biosynthetic gene cluster (PMID:16766657), while N-terminal regions of two other member proteins were named Trypco1 in a bioinformatic study (PMID:32101166) of predicted bacterial conflict systems.
Pssm-ID: 469044 [Multi-domain] Cd Length: 473 Bit Score: 39.99 E-value: 7.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 137 APPSQGPPGPLSATSLQTPPRPPQPSiLQPGSQVLPPPPTTLNGPGASP--LPLPMYRPDGLSGPPPPNAQ----YQPPP 210
Cdd:NF041121 20 APPSPEGPAPTAASQPATPPPPAAPP-SPPGDPPEPPAPEPAPLPAPYPgsLAPPPPPPPGPAGAAPGAALpvrvPAPPA 98
|
....
gi 190343021 211 LPGQ 214
Cdd:NF041121 99 LPNP 102
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
64-226 |
7.68e-03 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 40.40 E-value: 7.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 64 PGPHQfGQNGAHATGHPPQRFPgpppvnnvASSHAPYQPSAQSSYPGPISTSSVTQLGSQLSAMQinsygSGMAPPSQGP 143
Cdd:pfam09770 215 APAPA-QPPAAPPAQQAQQQQQ--------FPPQIQQQQQPQQQPQQPQQHPGQGHPVTILQRPQ-----SPQPDPAQPS 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 144 PGPLSATSLQTPPRPPQpsilQPgSQVLPPPpttlNGPGASPLPLPMYRPDGLSGPPPPNAQYQPPPLPGQTLGAGYPPQ 223
Cdd:pfam09770 281 IQPQAQQFHQQPPPVPV----QP-TQILQNP----NRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPIITHPQQ 351
|
...
gi 190343021 224 QAN 226
Cdd:pfam09770 352 LAQ 354
|
|
| PHA03201 |
PHA03201 |
uracil DNA glycosylase; Provisional |
156-225 |
7.91e-03 |
|
uracil DNA glycosylase; Provisional
Pssm-ID: 165468 Cd Length: 318 Bit Score: 39.49 E-value: 7.91e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 190343021 156 PRPPQPSilqPGSQVLPPPPTTLNGPGASPLPLPMYRPDGLSGPPPPNAQYQPPPL-------PGQTLGAGYPPQQA 225
Cdd:PHA03201 4 ARSRSPS---PPRRPSPPRPTPPRSPDASPEETPPSPPGPGAEPPPGRAAGPAAPRrrprgcpAGVTFSSSAPPRPP 77
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
11-267 |
8.41e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 40.31 E-value: 8.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 11 PYSQPQPGiGLSPPHYGHYGDPSHTA------SPTGmmKPAGPLGATATRGM--------------LPPGPPPPGPHQfg 70
Cdd:PHA03247 2492 AGAAPDPG-GGGPPDPDAPPAPSRLApailpdEPVG--EPVHPRMLTWIRGLeelasddagdppppLPPAAPPAAPDR-- 2566
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 71 qngahatghppqrfpgpppvnnvasSHAPYQPSAQSsyPGPISTSSVTQLGSQLSAmqinsyGSGMAP--PSQGPPGPLS 148
Cdd:PHA03247 2567 -------------------------SVPPPRPAPRP--SEPAVTSRARRPDAPPQS------ARPRAPvdDRGDPRGPAP 2613
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 149 ATSL---QTPPRPPQPS-------ILQPGSQVLPPPPTTLNGPGASPLPLP-----MYRPDGLSG--------------- 198
Cdd:PHA03247 2614 PSPLppdTHAPDPPPPSpspaanePDPHPPPTVPPPERPRDDPAPGRVSRPrrarrLGRAAQASSppqrprrraarptvg 2693
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 199 -------PPPPNAQYQPPPLP----------GQTLGAGYPPQQANSGPQMAGAQLSYPGG--FPGGPAQMAGPPQPQKKL 259
Cdd:PHA03247 2694 sltsladPPPPPPTPEPAPHAlvsatplppgPAAARQASPALPAAPAPPAVPAGPATPGGpaRPARPPTTAGPPAPAPPA 2773
|
....*...
gi 190343021 260 DPDSIPSP 267
Cdd:PHA03247 2774 APAAGPPR 2781
|
|
| PHA03379 |
PHA03379 |
EBNA-3A; Provisional |
94-278 |
8.66e-03 |
|
EBNA-3A; Provisional
Pssm-ID: 223066 [Multi-domain] Cd Length: 935 Bit Score: 40.04 E-value: 8.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 94 ASSHAPYQ----PSAQSSYPGPISTSS------VTQL----------GSQLSAmqINSYGSGMAPPSQGPPGPL----SA 149
Cdd:PHA03379 434 ATSHGSAQvpepPPVHDLEPGPLHDQHsmapcpVAQLppgplqdlepGDQLPG--VVQDGRPACAPVPAPAGPIvrpwEA 511
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 150 TSLQTPPRPPQPSILQPGSQVLPPPPTTLNGPGASPLP--LPMYRPDGLSG---------PPP--PNAQYQPPPLPGQT- 215
Cdd:PHA03379 512 SLSQVPGVAFAPVMPQPMPVEPVPVPTVALERPVCPAPplIAMQGPGETSGivrvrerwrPAPwtPNPPRSPSQMSVRDr 591
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 190343021 216 LGAGYPPQQANSGPqmAGAQlsyPGGFPGGPAQ--MAGPPQPQKKLDPDSIPSpiQVIENDRASR 278
Cdd:PHA03379 592 LARLRAEAQPYQAS--VEVQ---PPQLTQVSPQqpMEYPLEPEQQMFPGSPFS--QVADVMRAGG 649
|
|
| Drf_FH1 |
pfam06346 |
Formin Homology Region 1; This region is found in some of the Diaphanous related formins (Drfs) ... |
143-267 |
8.98e-03 |
|
Formin Homology Region 1; This region is found in some of the Diaphanous related formins (Drfs). It consists of low complexity repeats of around 12 residues.
Pssm-ID: 461881 [Multi-domain] Cd Length: 157 Bit Score: 37.93 E-value: 8.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190343021 143 PPGPLSATSLQTPPRPPQPSIlqpgsqvlpPPPTTLNGPGASPLPLPMYRPDGLSGPPP-PNAQY--QPPPLPGqtlGAG 219
Cdd:pfam06346 1 PPPPPLPGDSSTIPLPPGACI---------PTPPPLPGGGGPPPPPPLPGSAAIPPPPPlPGGTSipPPPPLPG---AAS 68
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 190343021 220 YPPQQANSGPQMAGAQLSYPG--GFPGGPAQMAG----PPQPQKKLDPDSIPSP 267
Cdd:pfam06346 69 IPPPPPLPGSTGIPPPPPLPGgaGIPPPPPPLPGgagvPPPPPPLPGGPGIPPP 122
|
|
| |
