|
Name |
Accession |
Description |
Interval |
E-value |
| SAPS |
pfam04499 |
SIT4 phosphatase-associated protein; This family includes a conserved region from a group of ... |
128-519 |
5.52e-152 |
|
SIT4 phosphatase-associated protein; This family includes a conserved region from a group of yeast proteins that associate with the SIT4 phosphatase. This association is required for SIT4's role in G1 cyclin transcription and for bud formation. This family also includes homologous regions from other eukaryotes.
Pssm-ID: 398279 Cd Length: 383 Bit Score: 451.69 E-value: 5.52e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 128 MGILINRKTDQLVSFLRKKDDFVDLLLQHIGTSAIMDLLLRLLTCVErPQLRQDVVNWLNEEKIVQRLIEQIHPSKDENQ 207
Cdd:pfam04499 1 NENLLDRKTDQMIEFIRKQENFVDKFLKHIDTPAIMDLLLKLISTDK-PELPTGVIEWLNEQNLIPKLLDLLSPSYDEDI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 208 HSNASQSLCDIIRLSREQMIQVQDSPEPDQLLATLEKQETIEQLLSNMFEGeQSQSVIVSGIQVLLTLLEPRRPRSESVT 287
Cdd:pfam04499 80 QSNASDFLKAIITISRNAPLQLQSSIGPNELTRELVSEESVEKLLDNMLKG-KSGSALVNGVGIIIELIRKNNSDYDPVQ 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 288 VNSFfssvdgQLELLAQGALESTVSSVgALHALRPRLSCFHQLLLEPPKLEPLQMTWGMLAPPLGNTRLHVVKLLASALS 367
Cdd:pfam04499 159 LLYT------TLEEHPPSDRDPIYLGH-LLRAFSPHLPDFHQLLLDPPKDSPLQTTLGVLIEPLGFERFKIVELIAELLH 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 368 ANDAALTHE---------LLALDVPNTMLDLFFHYVFNNFLHAQVEGCVSTMLSlgpppdSSPETPIQNPVVKHLLQQCR 438
Cdd:pfam04499 232 CSNMSLLNEkkgeklkikLVDLGIIPTILDLFFKYPWNNFLHNVVEDIIQQILN------GPMDFSYNSFLVVDLFTDCN 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 439 LVERILTSWEENDRVQCAGGPRKGYMGHLTRVAGALVQNTEKGPNAEQLRQLLKELpseQQEQWEAFVSGPLAETNKKNM 518
Cdd:pfam04499 306 LTQRILEGQKESDRFQAEKGPRLGYMGHLTLIAEEVVKFSEKYPPELISPDILEIL---ENEEWEEYVEETLEETRERYN 382
|
.
gi 151101459 519 V 519
Cdd:pfam04499 383 V 383
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
688-879 |
1.07e-07 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 56.10 E-value: 1.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 688 GCAARGGATPLSYPSPGPQPPGPSWTATFDPVPTDAPTSPRvsgEEELHTGPPAPQGPLSVPQGLPTQSLA-SPPARDAL 766
Cdd:PHA03247 2671 GRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPA---PHALVSATPLPPGPAAARQASPALPAApAPPAVPAG 2747
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 767 QLRSQDPTPPSAPQEATEGSKVTEPSAPC---QALVSIGDLQATFHGIRSAPSSSDSAtrDPSTSVPASGAHQPPQTTEG 843
Cdd:PHA03247 2748 PATPGGPARPARPPTTAGPPAPAPPAAPAagpPRRLTRPAVASLSESRESLPSPWDPA--DPPAAVLAPAAALPPAASPA 2825
|
170 180 190
....*....|....*....|....*....|....*.
gi 151101459 844 EKSPEPLGlpQSQSAQALTPPPIPNGSAPEGPASPG 879
Cdd:PHA03247 2826 GPLPPPTS--AQPTAPPPPPGPPPPSLPLGGSVAPG 2859
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
714-881 |
3.64e-07 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 54.56 E-value: 3.64e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 714 ATFDPVPTDAPTSPRVSGEEELHTGPPAPQGPLS-----VPQGLPTQSLASPP-------------------------AR 763
Cdd:PHA03247 2735 LPAAPAPPAVPAGPATPGGPARPARPPTTAGPPApappaAPAAGPPRRLTRPAvaslsesreslpspwdpadppaavlAP 2814
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 764 DALQLRSQDPTPPSAPQEATEGSKVTEPSAPCQALVSIGDLQATFHGI-RSAPSSSDSATRDPSTSVPASGAHQPPQTte 842
Cdd:PHA03247 2815 AAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVrRRPPSRSPAAKPAAPARPPVRRLARPAVS-- 2892
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 151101459 843 geKSPEPLGLPQSQSAQALTP-PPIPNGSAPEGPASPGSQ 881
Cdd:PHA03247 2893 --RSTESFALPPDQPERPPQPqAPPPPQPQPQPPPPPQPQ 2930
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
717-878 |
1.42e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 52.63 E-value: 1.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 717 DPVPTDAPTSPRVSGEEELHTGPPAPQGPLSVPQGLPTQSLASPPARDALQLRS-------QDPTPPSAPQEATEGSKVT 789
Cdd:PHA03247 2620 DTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAaqassppQRPRRRAARPTVGSLTSLA 2699
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 790 EPSAP-------CQALVSIGDLQAtfhGIRSAPSSSDSATRDPSTSVPASGAHQP--------PQTTEGEKSPEPLGLPQ 854
Cdd:PHA03247 2700 DPPPPpptpepaPHALVSATPLPP---GPAAARQASPALPAAPAPPAVPAGPATPggparparPPTTAGPPAPAPPAAPA 2776
|
170 180
....*....|....*....|....
gi 151101459 855 SQSAQALTPPPIPNgSAPEGPASP 878
Cdd:PHA03247 2777 AGPPRRLTRPAVAS-LSESRESLP 2799
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
718-878 |
1.25e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.55 E-value: 1.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 718 PVPTDAPTSPRVSGEEELHTGPP------APQGPLSVPQGLPTQSLASPPARDALQLRSQDPTPPSAPQEATEGSKVTEP 791
Cdd:PHA03247 257 PPPVVGEGADRAPETARGATGPPpppeaaAPNGAAAPPDGVWGAALAGAPLALPAPPDPPPPAPAGDAEEEDDEDGAMEV 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 792 SAPC---QALVSIG----------------DLQATFHGIRSA--PSSSDSATRDPSTSVPAS--GAHQPPQTTEGEKS-- 846
Cdd:PHA03247 337 VSPLprpRQHYPLGfpkrrrptwtppssleDLSAGRHHPKRAslPTRKRRSARHAATPFARGpgGDDQTRPAAPVPASvp 416
|
170 180 190
....*....|....*....|....*....|...
gi 151101459 847 -PEPLGLPQSQSAQALTPPPIPNGSAPEGPASP 878
Cdd:PHA03247 417 tPAPTPVPASAPPPPATPLPSAEPGSDDGPAPP 449
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
718-880 |
2.95e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 48.01 E-value: 2.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 718 PVPTDAPTSPRVSGEEELHTGPP---APQGPLSVPQGLPTQSLASPPARDALQLRSQDPTPPSAPQEATEGSKVTEPSAP 794
Cdd:PHA03247 2571 PRPAPRPSEPAVTSRARRPDAPPqsaRPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPE 2650
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 795 CQALVSIG-----DLQATFHGIRSAPSSSDSATRDPSTSVP----ASGAHQPPQTTEGEKSPEPL--GLP-------QSQ 856
Cdd:PHA03247 2651 RPRDDPAPgrvsrPRRARRLGRAAQASSPPQRPRRRAARPTvgslTSLADPPPPPPTPEPAPHALvsATPlppgpaaARQ 2730
|
170 180
....*....|....*....|....
gi 151101459 857 SAQALTPPPIPNgSAPEGPASPGS 880
Cdd:PHA03247 2731 ASPALPAAPAPP-AVPAGPATPGG 2753
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
718-876 |
5.81e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 46.90 E-value: 5.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 718 PVPTDAPTSPRVSGEeelhTGPPAPQGPLSVPQGLPTQSLASPPARDALQLRSQDPTPPSAPQEATEGSKVTEPSAPcqa 797
Cdd:PRK07764 609 PEEAARPAAPAAPAA----PAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAP--- 681
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 151101459 798 lvsigdlqatfhgirsAPSSSDSATRDPSTSVPASGAHQPPQTTEGEKSPEPLGLPQSQSAQALTPPPIPNGSAPEGPA 876
Cdd:PRK07764 682 ----------------PPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPE 744
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
738-880 |
8.68e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 46.38 E-value: 8.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 738 GPPAPQGPLSVPQGLPTQSLASPPARDALQLRSQDPTPPSAPQEATEGSKVTEPSAPCQALVSigdlqatfhgiRSAPS- 816
Cdd:PRK07003 366 GAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPA-----------APAPPa 434
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 151101459 817 SSDSATR---DPSTSVPASGAHQPPQTTEGEKSPEPLGLPQSQSAQAL-TPPPIPNGSAPEGPASPGS 880
Cdd:PRK07003 435 TADRGDDaadGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASdAPPDAAFEPAPRAAAPSAA 502
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
718-875 |
2.22e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 45.14 E-value: 2.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 718 PVPTDAPTSPRVSGEEELHTGPPAPQGPLSVPQGLP--------TQSLASPpardaLQLRSQDPT--PPSAPQEATEGSK 787
Cdd:pfam03154 177 QSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPatsqppnqTQSTAAP-----HTLIQQTPTlhPQRLPSPHPPLQP 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 788 VTEPSAPCQalVSIGDL-QATFHG-IRSAPSSSDSATRDPSTSVPASGAHQPPQTTEGEKSPEPLGLPQSQSAQAL-TPP 864
Cdd:pfam03154 252 MTQPPPPSQ--VSPQPLpQPSLHGqMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIhTPP 329
|
170
....*....|.
gi 151101459 865 PIPNGSAPEGP 875
Cdd:pfam03154 330 SQSQLQSQQPP 340
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
693-877 |
2.86e-04 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 44.67 E-value: 2.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 693 GGATPLSYPSPGPQPPGPSWTAT----FDPVPTDAPTSPRVSGEEELHTGPPAPQGPLSVPQGLPTqslaspPARdalql 768
Cdd:PHA03378 647 VFPTPHQPPQVEITPYKPTWTQIghipYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPG------RAQ----- 715
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 769 RSQDPTPPSAPQEATEGSKVTEPSAPCQAlvsigdlqatfhgirSAPSSSDSATRDPSTsvpASGAHQPPQTTEGEKSPE 848
Cdd:PHA03378 716 RPAAATGRARPPAAAPGRARPPAAAPGRA---------------RPPAAAPGRARPPAA---APGRARPPAAAPGAPTPQ 777
|
170 180 190
....*....|....*....|....*....|...
gi 151101459 849 PL----GLPQSQSAQALTPPPIPNGsapeGPAS 877
Cdd:PHA03378 778 PPpqapPAPQQRPRGAPTPQPPPQA----GPTS 806
|
|
| PTZ00249 |
PTZ00249 |
variable surface protein Vir28; Provisional |
718-863 |
3.03e-04 |
|
variable surface protein Vir28; Provisional
Pssm-ID: 140276 [Multi-domain] Cd Length: 516 Bit Score: 44.25 E-value: 3.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 718 PVPTDAPTSPRVSGEEELHTGPPAPQGpLSVPQ--GLP-----TQSLASPPARDALQLRS-QDPTPPSapqeategskVT 789
Cdd:PTZ00249 239 PPKHISFSSPHAHGRPPVETRPPNPVS-VSSPQahGRHpgethTPPLVTVPSSKAHDRNPvQTPTPTS----------VS 307
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 151101459 790 EPSAPCQALvsigDLQAtfhGIRSAPSSSDSATRDPST-----SVPASGAHQPPQTTEGEKSPEPLGLPQSQSAQALTP 863
Cdd:PTZ00249 308 GYSSQAKGL----EKQA---GGESERTSSVPSEQFPLPlpvllPLGQSGPLESSESEETDEYAGPKGLPEPELELVELQ 379
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
720-878 |
3.88e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 44.54 E-value: 3.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 720 PTDAPTSPR----VSGEEELHT----GPPAPQGPLSVP----QGLPTQSLASPPARDALQLRSQDPTPPsaPQEATEGSK 787
Cdd:PHA03247 2524 PVGEPVHPRmltwIRGLEELASddagDPPPPLPPAAPPaapdRSVPPPRPAPRPSEPAVTSRARRPDAP--PQSARPRAP 2601
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 788 VTEPSAPCQALvsigdlqatfhgiRSAPSSSDSATRDPSTSVPASGAHQP--------PQTTEGEKSPEPLGLPQSQSAQ 859
Cdd:PHA03247 2602 VDDRGDPRGPA-------------PPSPLPPDTHAPDPPPPSPSPAANEPdphppptvPPPERPRDDPAPGRVSRPRRAR 2668
|
170
....*....|....*....
gi 151101459 860 ALTPPPIPNgSAPEGPASP 878
Cdd:PHA03247 2669 RLGRAAQAS-SPPQRPRRR 2686
|
|
| PHA03195 |
PHA03195 |
tegument protein VP11/12; Provisional |
742-875 |
6.85e-04 |
|
tegument protein VP11/12; Provisional
Pssm-ID: 177556 Cd Length: 746 Bit Score: 43.46 E-value: 6.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 742 PQGPLSVPQGLPT----------------QSLASPPaRDALQLRSQDPTPPSAPQEATEGSKVTEPSAPCQALVSIGDLQ 805
Cdd:PHA03195 441 PQGPLPAPPNSKTrgtfrrprpgsvrgsrQLPASPP-SNIVSPRTNPAAEGSTAAKNGQGAETIQVRSSGEFNDCIWYLN 519
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 151101459 806 ATFHGIRSAPSSSDSATRD----PSTSVPASgahqPPQTTEGEKSPEPLGLPQSQSAQALTPPPIPNGSAPEGP 875
Cdd:PHA03195 520 GAYPHQRSDSSSSDNSTCSstetQYITLPST----PSPTGEVVYTNPLLGPDEEVDASPQPVDPVSDYSAPKNP 589
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
736-880 |
2.34e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 41.51 E-value: 2.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 736 HTGPPAPQGPLSVPQGLPTQSLASPPARDALQLRSQDPTPPSAPQEATEGSkvtepsapcqalvsigdlqatfhgirsAP 815
Cdd:PRK07764 390 GAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPA---------------------------PP 442
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 151101459 816 SSSDSATRDPSTSVPASGAHQPPQTTEGEKSPEPLGLPQSQSAQALTPPPIPNGSAPEGPASPGS 880
Cdd:PRK07764 443 SPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGAD 507
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
716-879 |
2.89e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 41.40 E-value: 2.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 716 FDPVPTDAPTSPRVSGEEELHTGPPAPQGPLSVpqglpTQSLASPPARDAlqlrsqdPTPPSAPQEATEGSKVTEPSAPC 795
Cdd:PRK12323 363 FRPGQSGGGAGPATAAAAPVAQPAPAAAAPAAA-----APAPAAPPAAPA-------AAPAAAAAARAVAAAPARRSPAP 430
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 796 QALVSIGDLQATFHGIRSAPSSSDSATRDPSTSVPASGAHQPPQTtegEKSPEPLGLPQSQSAQALTPPPiPNGSAPEGP 875
Cdd:PRK12323 431 EALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAA---AAAAPARAAPAAAPAPADDDPP-PWEELPPEF 506
|
....
gi 151101459 876 ASPG 879
Cdd:PRK12323 507 ASPA 510
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
737-881 |
4.11e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 40.74 E-value: 4.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 737 TGPPAPQGPLSVPQGL--PTQSLASPPARDALQLRSQDPTPPSAPQEATEGSKVTEPSAPCQALVSIGDLQATFHGIRSA 814
Cdd:PRK07764 598 EGPPAPASSGPPEEAArpAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAA 677
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 815 PSSS-----DSATRDPSTSVPASGAHQPPQTTEGEKSPEPLGLPQSQSAQALTP-------------------------- 863
Cdd:PRK07764 678 PAAPppapaPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPspaaddpvplppepddppdpagapaq 757
|
170 180
....*....|....*....|..
gi 151101459 864 ----PPIPNGSAPEGPASPGSQ 881
Cdd:PRK07764 758 ppppPAPAPAAAPAAAPPPSPP 779
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
713-877 |
4.74e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 40.60 E-value: 4.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 713 TATFDPVPTDAPTSPRVSGeeelhtGPPAPQGPLSVPQGLPTQSLAsPPARDAlQLRSQDPTPPSAPQEATEGSKVTEPS 792
Cdd:PRK07003 386 RAAAAVGASAVPAVTAVTG------AAGAALAPKAAAAAAATRAEA-PPAAPA-PPATADRGDDAADGDAPVPAKANARA 457
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 793 APCQALVSIGDLQATFHGIRSAPSSSdsaTRDPSTSVPASGAHQP-PQTTEGEKSPEPLGLPQSQSAQALTPPPIPNGSA 871
Cdd:PRK07003 458 SADSRCDERDAQPPADSGSASAPASD---APPDAAFEPAPRAAAPsAATPAAVPDARAPAAASREDAPAAAAPPAPEARP 534
|
....*.
gi 151101459 872 PEGPAS 877
Cdd:PRK07003 535 PTPAAA 540
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
690-794 |
6.62e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 40.31 E-value: 6.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 690 AARGGATPLSYPSPGPQPPGPSWTAtfdPVPTDAPTSPRVsgeeeLHTGPPAPQGPLSVPQGLPTQSLASPPARD--ALQ 767
Cdd:PHA03247 387 SARHAATPFARGPGGDDQTRPAAPV---PASVPTPAPTPV-----PASAPPPPATPLPSAEPGSDDGPAPPPERQppAPA 458
|
90 100
....*....|....*....|....*..
gi 151101459 768 LRSQDPTPPSAPQEATEGSKVTEPSAP 794
Cdd:PHA03247 459 TEPAPDDPDDATRKALDALRERRPPEP 485
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
719-873 |
7.86e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 40.14 E-value: 7.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 719 VPTDAPTSPRVSGEEEL--HTGPPAPQGPLSV-PQGlptQSLASPPARDALQLRSQDPTPPSA--PQEATEGSKVTEPSA 793
Cdd:pfam03154 386 MNSNLPPPPALKPLSSLstHHPPSAHPPPLQLmPQS---QQLPPPPAQPPVLTQSQSLPPPAAshPPTSGLHQVPSQSPF 462
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 151101459 794 PCQALVSIGDLQAT-FHGIRSAPSSSDSATRDPSTSVPASGAHQPPQTTEGEKSPEPLGLPQSQSAQALTPPPIPNGSAP 872
Cdd:pfam03154 463 PQHPFVPGGPPPITpPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRSPSP 542
|
.
gi 151101459 873 E 873
Cdd:pfam03154 543 E 543
|
|
|