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Conserved domains on  [gi|7662340|ref|NP_055756|]
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ATPase MORC2 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HATPase super family cl00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 1-73 1.13e-35

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


The actual alignment was detected with superfamily member cd16931:

Pssm-ID: 469604 [Multi-domain]  Cd Length: 118  Bit Score: 130.99  E-value: 1.13e-35
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7662340    1 MLCFLDDGAGMDPSDAASVIQFGKSAKRTPESTQIGQYGNGLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFH 73
Cdd:cd16931  46 MLSFLDDGNGMTPEEAHHMISFGFSDKRSDDHDHIGRYGNGFKSGSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 433-480 1.89e-16

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


:

Pssm-ID: 462181  Cd Length: 46  Bit Score: 73.88  E-value: 1.89e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 7662340    433 TTIQCDLCLKWRTLPFQLSSVEKdyPDTWVCSMNPDPEQDRCEASEQK 480
Cdd:pfam07496   1 YWVQCDSCLKWRRLPTEIDPYEL--PEPWYCSMNPDPKYNSCDAPEEI 46
Morc6_S5 super family cl39387
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 177-389 4.14e-12

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


The actual alignment was detected with superfamily member pfam17942:

Pssm-ID: 465579  Cd Length: 139  Bit Score: 64.49  E-value: 4.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662340    177 SFRAYAAVLY--IDPRMRIFIHGHKVQTKRLS-------CCLYKPrmykytssrfktraeqevkkaeHVARIAEEKArea 247
Cdd:pfam17942   2 SLRAYASILYlrLPPNFQIILRGKKVEHHNIAddlkypeKITYKP----------------------QVGGGKEVVV--- 56

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662340    248 eskartlEVRLGgdltrdsrvmlrqvqnraitlrreadvkkRIKEAKQralkepkeLNfVFGVNIEHRDldgmfiyncsR 327
Cdd:pfam17942  57 -------ITTIG-----------------------------FLKEAPH--------IN-VHGFNVYHKN----------R 81

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7662340    328 LIKMYEKVGPQ-----------LEGGmacggvvgvvdvpylVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYW 389
Cdd:pfam17942  82 LIKPFWRVGNQagskgrgvigvLEAN---------------FIEPTHDKQDFERTSLYQRLEARLKQMLKEYW 139
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 558-673 5.42e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 5.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662340    558 AVIRNAPSRPPSLPTPRPASQPRKAPVISSTPKLPALAAREEAstsrllqpPEAPRKPANTLVKTASRPAPLVQQLSPSL 637
Cdd:PHA03247 2726 AAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPA--------PAPPAAPAAGPPRRLTRPAVASLSESRES 2797

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 7662340    638 LPNSKSPREVPSPKVIKTPVVKKTESPIKLSPATPS 673
Cdd:PHA03247 2798 LPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTS 2833
 
Name Accession Description Interval E-value
HATPase_MORC-like cd16931
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
 1-73 1.13e-35

Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.


Pssm-ID: 340408 [Multi-domain]  Cd Length: 118  Bit Score: 130.99  E-value: 1.13e-35
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7662340    1 MLCFLDDGAGMDPSDAASVIQFGKSAKRTPESTQIGQYGNGLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFH 73
Cdd:cd16931  46 MLSFLDDGNGMTPEEAHHMISFGFSDKRSDDHDHIGRYGNGFKSGSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 1-107 3.52e-28

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 110.50  E-value: 3.52e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662340      1 MLCFLDDGAGMDPSDAASVIQFGKSAKRTP-ESTQIGQYGNGLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFHEEEGiD 79
Cdd:pfam13589  33 EIVIEDDGHGMSPEELINALRLATSAKEAKrGSTDLGRYGIGLKLASLSLGAKLTVTSKKEGKSSTLTLDRDKISNEN-D 111

                          90       100
                  ....*....|....*....|....*...
gi 7662340     80 EVIVPLPTWnartREPVTDNVEKFAIET 107
Cdd:pfam13589 112 WLLPLLTPA----PIENFDELDKDAHGT 135
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 433-480 1.89e-16

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 73.88  E-value: 1.89e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 7662340    433 TTIQCDLCLKWRTLPFQLSSVEKdyPDTWVCSMNPDPEQDRCEASEQK 480
Cdd:pfam07496   1 YWVQCDSCLKWRRLPTEIDPYEL--PEPWYCSMNPDPKYNSCDAPEEI 46
Morc6_S5 pfam17942
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 177-389 4.14e-12

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


Pssm-ID: 465579  Cd Length: 139  Bit Score: 64.49  E-value: 4.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662340    177 SFRAYAAVLY--IDPRMRIFIHGHKVQTKRLS-------CCLYKPrmykytssrfktraeqevkkaeHVARIAEEKArea 247
Cdd:pfam17942   2 SLRAYASILYlrLPPNFQIILRGKKVEHHNIAddlkypeKITYKP----------------------QVGGGKEVVV--- 56

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662340    248 eskartlEVRLGgdltrdsrvmlrqvqnraitlrreadvkkRIKEAKQralkepkeLNfVFGVNIEHRDldgmfiyncsR 327
Cdd:pfam17942  57 -------ITTIG-----------------------------FLKEAPH--------IN-VHGFNVYHKN----------R 81

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7662340    328 LIKMYEKVGPQ-----------LEGGmacggvvgvvdvpylVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYW 389
Cdd:pfam17942  82 LIKPFWRVGNQagskgrgvigvLEAN---------------FIEPTHDKQDFERTSLYQRLEARLKQMLKEYW 139
PHA03247 PHA03247
large tegument protein UL36; Provisional
 558-673 5.42e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 5.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662340    558 AVIRNAPSRPPSLPTPRPASQPRKAPVISSTPKLPALAAREEAstsrllqpPEAPRKPANTLVKTASRPAPLVQQLSPSL 637
Cdd:PHA03247 2726 AAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPA--------PAPPAAPAAGPPRRLTRPAVASLSESRES 2797

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 7662340    638 LPNSKSPREVPSPKVIKTPVVKKTESPIKLSPATPS 673
Cdd:PHA03247 2798 LPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTS 2833
PTZ00121 PTZ00121
MAEBL; Provisional
 223-302 8.04e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.12  E-value: 8.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662340    223 KTRAEQEVKKAEHVARIAEEKAREAESKARTLEVRLGGDLTRDSrvmlrQVQNRAITLRREADVKKRIKEAKQRALKEPK 302
Cdd:PTZ00121 1397 KKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKA-----EEAKKADEAKKKAEEAKKAEEAKKKAEEAKK 1471
 
Name Accession Description Interval E-value
HATPase_MORC-like cd16931
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
 1-73 1.13e-35

Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.


Pssm-ID: 340408 [Multi-domain]  Cd Length: 118  Bit Score: 130.99  E-value: 1.13e-35
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7662340    1 MLCFLDDGAGMDPSDAASVIQFGKSAKRTPESTQIGQYGNGLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFH 73
Cdd:cd16931  46 MLSFLDDGNGMTPEEAHHMISFGFSDKRSDDHDHIGRYGNGFKSGSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 1-107 3.52e-28

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 110.50  E-value: 3.52e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662340      1 MLCFLDDGAGMDPSDAASVIQFGKSAKRTP-ESTQIGQYGNGLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFHEEEGiD 79
Cdd:pfam13589  33 EIVIEDDGHGMSPEELINALRLATSAKEAKrGSTDLGRYGIGLKLASLSLGAKLTVTSKKEGKSSTLTLDRDKISNEN-D 111

                          90       100
                  ....*....|....*....|....*...
gi 7662340     80 EVIVPLPTWnartREPVTDNVEKFAIET 107
Cdd:pfam13589 112 WLLPLLTPA----PIENFDELDKDAHGT 135
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 433-480 1.89e-16

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 73.88  E-value: 1.89e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 7662340    433 TTIQCDLCLKWRTLPFQLSSVEKdyPDTWVCSMNPDPEQDRCEASEQK 480
Cdd:pfam07496   1 YWVQCDSCLKWRRLPTEIDPYEL--PEPWYCSMNPDPKYNSCDAPEEI 46
Morc6_S5 pfam17942
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 177-389 4.14e-12

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


Pssm-ID: 465579  Cd Length: 139  Bit Score: 64.49  E-value: 4.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662340    177 SFRAYAAVLY--IDPRMRIFIHGHKVQTKRLS-------CCLYKPrmykytssrfktraeqevkkaeHVARIAEEKArea 247
Cdd:pfam17942   2 SLRAYASILYlrLPPNFQIILRGKKVEHHNIAddlkypeKITYKP----------------------QVGGGKEVVV--- 56

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662340    248 eskartlEVRLGgdltrdsrvmlrqvqnraitlrreadvkkRIKEAKQralkepkeLNfVFGVNIEHRDldgmfiyncsR 327
Cdd:pfam17942  57 -------ITTIG-----------------------------FLKEAPH--------IN-VHGFNVYHKN----------R 81

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7662340    328 LIKMYEKVGPQ-----------LEGGmacggvvgvvdvpylVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYW 389
Cdd:pfam17942  82 LIKPFWRVGNQagskgrgvigvLEAN---------------FIEPTHDKQDFERTSLYQRLEARLKQMLKEYW 139
PHA03247 PHA03247
large tegument protein UL36; Provisional
 558-673 5.42e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 5.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662340    558 AVIRNAPSRPPSLPTPRPASQPRKAPVISSTPKLPALAAREEAstsrllqpPEAPRKPANTLVKTASRPAPLVQQLSPSL 637
Cdd:PHA03247 2726 AAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPA--------PAPPAAPAAGPPRRLTRPAVASLSESRES 2797

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 7662340    638 LPNSKSPREVPSPKVIKTPVVKKTESPIKLSPATPS 673
Cdd:PHA03247 2798 LPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTS 2833
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 571-677 8.71e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 46.61  E-value: 8.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662340   571 PTPRPASQPRKAPVISSTPKLPalaareeaSTSRLLQPPEAPRKPAN--TLVKTASRPAPLVQQL-----SPSLLPNSKS 643
Cdd:PTZ00449 561 PGPAKEHKPSKIPTLSKKPEFP--------KDPKHPKDPEEPKKPKRprSAQRPTRPKSPKLPELldipkSPKRPESPKS 632

                         90       100       110
                 ....*....|....*....|....*....|....
gi 7662340   644 PREVPSPKVIKTPvvKKTESPikLSPATPSRKRS 677
Cdd:PTZ00449 633 PKRPPPPQRPSSP--ERPEGP--KIIKSPKPPKS 662
PHA03247 PHA03247
large tegument protein UL36; Provisional
 562-676 1.85e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 1.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662340    562 NAPSRPPSLPTPrPASQPRKAPVISSTPKLPALA------AREEASTSRLLQPPEAPRKPANTLVKTASRPAPLV----- 630
Cdd:PHA03247 2755 ARPARPPTTAGP-PAPAPPAAPAAGPPRRLTRPAvaslseSRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLpppts 2833

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 7662340    631 -QQLSPSLLPNSKSPREVPSPKVIKTPVVKK--TESPIKLSPATPSRKR 676
Cdd:PHA03247 2834 aQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRrpPSRSPAAKPAAPARPP 2882
PHA03247 PHA03247
large tegument protein UL36; Provisional
 563-672 3.04e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 3.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662340    563 APSRPPSLPTPRPASQPRKAPVISSTPKLPALA-----------AREEASTSRLLQPPEAPRKPantlvktASRP--APL 629
Cdd:PHA03247 2623 APDPPPPSPSPAANEPDPHPPPTVPPPERPRDDpapgrvsrprrARRLGRAAQASSPPQRPRRR-------AARPtvGSL 2695

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 7662340    630 VQQLSPSllPNSKSPREVPSPKVIKTPVVKKTESPIKLSPATP 672
Cdd:PHA03247 2696 TSLADPP--PPPPTPEPAPHALVSATPLPPGPAAARQASPALP 2736
PHA03247 PHA03247
large tegument protein UL36; Provisional
 534-679 3.75e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 3.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662340    534 EVTTRPSTEEPVRRPQRPRSPPLPAVIRNAPSRPP-SLPTPRPASQPRKAPvisSTPKLPALAAREEASTSRLLQPPEAP 612
Cdd:PHA03247 2861 DVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTeSFALPPDQPERPPQP---QAPPPPQPQPQPPPPPQPQPPPPPPP 2937

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7662340    613 RKPANTLVKTASRPAPLVQQLSPSLLPNSKSPREVPSPKVIKTPVVKKTESPiklSPATPSRKRSVA 679
Cdd:PHA03247 2938 RPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAP---ASSTPPLTGHSL 3001
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 563-678 4.06e-04

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 43.31  E-value: 4.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662340   563 APSRPPSLPTPRPASQPRKAPVISSTPKLPALAAREEASTSRLLQPPEAPRKPANTLVKtASRPAPLVQQLSPSLLPNSK 642
Cdd:PHA02682 102 APAPAVTCPAPAPACPPATAPTCPPPAVCPAPARPAPACPPSTRQCPPAPPLPTPKPAP-AAKPIFLHNQLPPPDYPAAS 180

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 7662340   643 SPREVPSPKVikTPVVkKTESPIKLSPATPSRKRSV 678
Cdd:PHA02682 181 CPTIETAPAA--SPVL-EPRIPDKIIDADNDDKDLI 213
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 563-673 1.44e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.39  E-value: 1.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662340   563 APSRPPSLPT-PRPASQPRKAPVISSTPKLPALAAREEASTSrLLQPPEAPRKPANTLVKTASRPAplvqqlSPSLLPNS 641
Cdd:PRK14951 376 AEKKTPARPEaAAPAAAPVAQAAAAPAPAAAPAAAASAPAAP-PAAAPPAPVAAPAAAAPAAAPAA------APAAVALA 448

                         90       100       110
                 ....*....|....*....|....*....|..
gi 7662340   642 KSPREVPSPKVIKTPVVKKTESPIKLSPATPS 673
Cdd:PRK14951 449 PAPPAQAAPETVAIPVRVAPEPAVASAAPAPA 480
PHA03247 PHA03247
large tegument protein UL36; Provisional
 561-673 2.20e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 2.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662340    561 RNAPSrPPSLPTPRPASQPRKAPVISSTPKLPA-LAAREE-ASTSRLLQPPEAPRKPANTLVKTASR-PAPLVQQLSPSL 637
Cdd:PHA03247 2653 RDDPA-PGRVSRPRRARRLGRAAQASSPPQRPRrRAARPTvGSLTSLADPPPPPPTPEPAPHALVSAtPLPPGPAAARQA 2731

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 7662340    638 LPnsKSPREVPSPKVIKTPVVKKTESPIKlSPATPS 673
Cdd:PHA03247 2732 SP--ALPAAPAPPAVPAGPATPGGPARPA-RPPTTA 2764
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 562-669 3.35e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 41.07  E-value: 3.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662340   562 NAPSRPPSLPTPRPASQPRKAPVISSTPKLPALAAREE------ASTSRL--------LQPPEAPRKPANTLVKTASRPA 627
Cdd:PLN03209 322 KIPSQRVPPKESDAADGPKPVPTKPVTPEAPSPPIEEEppqpkaVVPRPLspytayedLKPPTSPIPTPPSSSPASSKSV 401

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 7662340   628 PLVQQL-SPSLLPNSKSPREVPSPKVIktPVVKKTESPikLSP 669
Cdd:PLN03209 402 DAVAKPaEPDVVPSPGSASNVPEVEPA--QVEAKKTRP--LSP 440
PTZ00121 PTZ00121
MAEBL; Provisional
 223-302 8.04e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.12  E-value: 8.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662340    223 KTRAEQEVKKAEHVARIAEEKAREAESKARTLEVRLGGDLTRDSrvmlrQVQNRAITLRREADVKKRIKEAKQRALKEPK 302
Cdd:PTZ00121 1397 KKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKA-----EEAKKADEAKKKAEEAKKAEEAKKKAEEAKK 1471
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 563-648 8.71e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 39.70  E-value: 8.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662340   563 APSRPPSLPTPRPASQPRKAPVISSTPKLPALAAREEAStsrllqPPEAPRKPANTLVKTASRPAPLVQQLSPSLLPNSK 642
Cdd:PRK14951 413 APAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAP------PAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAA 486


                 ....*.
gi 7662340   643 SPREVP 648
Cdd:PRK14951 487 RLTPTE 492
PHA03247 PHA03247
large tegument protein UL36; Provisional
 563-682 9.41e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 9.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662340    563 APSRPP-----SLPTPRPASQPRKAPVIS--STPKLPALAAREEA----STSRLLQPPEAPRKPANT-LVKTASRPAPLV 630
Cdd:PHA03247 2556 PPAAPPaapdrSVPPPRPAPRPSEPAVTSraRRPDAPPQSARPRApvddRGDPRGPAPPSPLPPDTHaPDPPPPSPSPAA 2635

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 7662340    631 QQL---SPSLLPNSKSPREVPSPKVIKTPVVKKTESPIKLSPATPSRKRSVAVSD 682
Cdd:PHA03247 2636 NEPdphPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARP 2690
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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