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Conserved domains on  [gi|24307999|ref|NP_055956|]
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glycerol-3-phosphate dehydrogenase 1-like protein [Homo sapiens]

Protein Classification

glycerol-3-phosphate dehydrogenase family protein( domain architecture ID 11496765)

glycerol-3-phosphate dehydrogenase family protein is similar to human L-alpha-glycerol-3-phosphate dehydrogenase 1 (GPD1), which catalyzes the reversible biological conversion of dihydroxyacetone (DHAP) to glycerol-3-phosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 7-344 0e+00

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


:

Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 509.19  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999     7 KVCIVGSGNWGSAVAKIIGNNVKKL-QKFASTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAMSNLSEAV 85
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENARALpELFEESVRMWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLVAVPDLVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999    86 QDADLLVFVIPHQFIHRICDEITGRVPKKALGITLIKGIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAAEKFCE 165
Cdd:TIGR03376  81 KGADILVFVIPHQFLEGICKQLKGHVKPNARAISCIKGLEVSKDGVKLLSDIIEEELGIPCGVLSGANLANEVAKEKFSE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999   166 TTIGSKVMEN----GLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFA 241
Cdd:TIGR03376 161 TTVGYRDPADfdvdARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLEMIKFA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999   242 RIFCKGQVSTATFlESCGVADLITTCYGGRNRRVAEAFARTGKTIEELEKEMLNGQKLQGPQTSAEVYRILKQKGLLDKF 321
Cdd:TIGR03376 241 RMFFPTGEVTFTF-ESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKNKDDEF 319

                         330       340
                  ....*....|....*....|...
gi 24307999   322 PLFTAVYQICYESRPVQEMLSCL 344
Cdd:TIGR03376 320 PLFEAVYQILYEGLPPKKLPECL 342
 
Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 7-344 0e+00

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 509.19  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999     7 KVCIVGSGNWGSAVAKIIGNNVKKL-QKFASTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAMSNLSEAV 85
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENARALpELFEESVRMWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLVAVPDLVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999    86 QDADLLVFVIPHQFIHRICDEITGRVPKKALGITLIKGIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAAEKFCE 165
Cdd:TIGR03376  81 KGADILVFVIPHQFLEGICKQLKGHVKPNARAISCIKGLEVSKDGVKLLSDIIEEELGIPCGVLSGANLANEVAKEKFSE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999   166 TTIGSKVMEN----GLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFA 241
Cdd:TIGR03376 161 TTVGYRDPADfdvdARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLEMIKFA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999   242 RIFCKGQVSTATFlESCGVADLITTCYGGRNRRVAEAFARTGKTIEELEKEMLNGQKLQGPQTSAEVYRILKQKGLLDKF 321
Cdd:TIGR03376 241 RMFFPTGEVTFTF-ESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKNKDDEF 319

                         330       340
                  ....*....|....*....|...
gi 24307999   322 PLFTAVYQICYESRPVQEMLSCL 344
Cdd:TIGR03376 320 PLFEAVYQILYEGLPPKKLPECL 342
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 3-344 8.18e-163

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 459.49  E-value: 8.18e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999    3 AAPLKVCIVGSGNWGSAVAKIIGNNVKKLQKFASTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAMSNLS 82
Cdd:PTZ00345   9 CGPLKVSVIGSGNWGSAISKVVGENTQRNYIFHNEVRMWVLEEIVEGEKLSDIINTKHENVKYLPGIKLPDNIVAVSDLK 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999   83 EAVQDADLLVFVIPHQFIHRICDEI--TGRVPKKALGITLIKGIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAA 160
Cdd:PTZ00345  89 EAVEDADLLIFVIPHQFLESVLSQIkeNNNLKKHARAISLTKGIIVENGKPVLCSDVIEEELGIPCCALSGANVANDVAR 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999  161 EKFCETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAF 240
Cdd:PTZ00345 169 EEFSEATIGCEDKDDALIWQRLFDRPYFKINCVPDVIGVEVCGALKNIIALAAGFCDGLGLGTNTKSAIIRIGLEEMKLF 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999  241 ARIFCKgQVSTATFLESCGVADLITTCYGGRNRRVAEAFARTG--KTIEELEKEMLNGQKLQGPQTSAEVYRILKQKGLL 318
Cdd:PTZ00345 249 GKIFFP-NVMDETFFESCGLADLITTCLGGRNVRCAAEFAKRNgkKSWEEIEAELLNGQKLQGTVTLKEVYEVLESHDLK 327

                        330       340
                 ....*....|....*....|....*.
gi 24307999  319 DKFPLFTAVYQICYESRPVQEMLSCL 344
Cdd:PTZ00345 328 KEFPLFTVTYKIAFEGADPSSLIDVL 353
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 7-348 5.09e-91

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 275.38  E-value: 5.09e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999   7 KVCIVGSGNWGSAVAKIIGNNvkklqkfASTVKMWVFEETVngrklTDIINNDHENVKYLPGHKLPENVVAMSNLSEAVQ 86
Cdd:COG0240   2 KIAVLGAGSWGTALAKVLARN-------GHEVTLWGRDPEV-----AEEINETRENPRYLPGVKLPENLRATSDLEEALA 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999  87 DADLLVFVIPHQFIHRICDEITGRVPKKALGITLIKGIDegPEGLKLISDIIREKMGID--ISVLMGANIANEVAAEKFC 164
Cdd:COG0240  70 GADLVLLAVPSQALREVLEQLAPLLPPGAPVVSATKGIE--PGTGLLMSEVIAEELPGAlrIAVLSGPSFAEEVARGLPT 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999 165 ETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFARIF 244
Cdd:COG0240 148 AVVVASEDEEVAERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGVAL 227

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999 245 ckgQVSTATFLESCGVADLITTCYG--GRNRRVAEAFARtGKTIEELEKEMlnGQKLQGPQTSAEVYRILKQKGLldKFP 322
Cdd:COG0240 228 ---GARPETFMGLAGLGDLVLTCTSdlSRNRRFGLALGK-GKSLEEALAEM--GMVAEGVYTAKAVYELAEKLGV--EMP 299

                       330       340
                ....*....|....*....|....*.
gi 24307999 323 LFTAVYQICYESRPVQEMLSCLQSHP 348
Cdd:COG0240 300 ITEAVYAVLYEGKSPREAVEALMARP 325
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 195-341 9.79e-63

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 196.46  E-value: 9.79e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999   195 DADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFARIFCKgqvSTATFLESCGVADLITTCYGG--RN 272
Cdd:pfam07479   1 DVIGVELGGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLGKALGA---KPETFFGLAGLGDLIVTCTSGlsRN 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24307999   273 RRVAEAFARtGKTIEELEKEMlnGQKLQGPQTSAEVYRILKQKGLldKFPLFTAVYQICYESRPVQEML 341
Cdd:pfam07479  78 RRFGEALGK-GKSLEEAEKEL--GQVAEGVYTAKAVYELAKKLGV--EMPIFEAVYRILYEGKSPEEAL 141
 
Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 7-344 0e+00

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 509.19  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999     7 KVCIVGSGNWGSAVAKIIGNNVKKL-QKFASTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAMSNLSEAV 85
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENARALpELFEESVRMWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLVAVPDLVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999    86 QDADLLVFVIPHQFIHRICDEITGRVPKKALGITLIKGIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAAEKFCE 165
Cdd:TIGR03376  81 KGADILVFVIPHQFLEGICKQLKGHVKPNARAISCIKGLEVSKDGVKLLSDIIEEELGIPCGVLSGANLANEVAKEKFSE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999   166 TTIGSKVMEN----GLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFA 241
Cdd:TIGR03376 161 TTVGYRDPADfdvdARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLEMIKFA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999   242 RIFCKGQVSTATFlESCGVADLITTCYGGRNRRVAEAFARTGKTIEELEKEMLNGQKLQGPQTSAEVYRILKQKGLLDKF 321
Cdd:TIGR03376 241 RMFFPTGEVTFTF-ESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKNKDDEF 319

                         330       340
                  ....*....|....*....|...
gi 24307999   322 PLFTAVYQICYESRPVQEMLSCL 344
Cdd:TIGR03376 320 PLFEAVYQILYEGLPPKKLPECL 342
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 3-344 8.18e-163

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 459.49  E-value: 8.18e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999    3 AAPLKVCIVGSGNWGSAVAKIIGNNVKKLQKFASTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAMSNLS 82
Cdd:PTZ00345   9 CGPLKVSVIGSGNWGSAISKVVGENTQRNYIFHNEVRMWVLEEIVEGEKLSDIINTKHENVKYLPGIKLPDNIVAVSDLK 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999   83 EAVQDADLLVFVIPHQFIHRICDEI--TGRVPKKALGITLIKGIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAA 160
Cdd:PTZ00345  89 EAVEDADLLIFVIPHQFLESVLSQIkeNNNLKKHARAISLTKGIIVENGKPVLCSDVIEEELGIPCCALSGANVANDVAR 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999  161 EKFCETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAF 240
Cdd:PTZ00345 169 EEFSEATIGCEDKDDALIWQRLFDRPYFKINCVPDVIGVEVCGALKNIIALAAGFCDGLGLGTNTKSAIIRIGLEEMKLF 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999  241 ARIFCKgQVSTATFLESCGVADLITTCYGGRNRRVAEAFARTG--KTIEELEKEMLNGQKLQGPQTSAEVYRILKQKGLL 318
Cdd:PTZ00345 249 GKIFFP-NVMDETFFESCGLADLITTCLGGRNVRCAAEFAKRNgkKSWEEIEAELLNGQKLQGTVTLKEVYEVLESHDLK 327

                        330       340
                 ....*....|....*....|....*.
gi 24307999  319 DKFPLFTAVYQICYESRPVQEMLSCL 344
Cdd:PTZ00345 328 KEFPLFTVTYKIAFEGADPSSLIDVL 353
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 7-348 5.09e-91

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 275.38  E-value: 5.09e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999   7 KVCIVGSGNWGSAVAKIIGNNvkklqkfASTVKMWVFEETVngrklTDIINNDHENVKYLPGHKLPENVVAMSNLSEAVQ 86
Cdd:COG0240   2 KIAVLGAGSWGTALAKVLARN-------GHEVTLWGRDPEV-----AEEINETRENPRYLPGVKLPENLRATSDLEEALA 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999  87 DADLLVFVIPHQFIHRICDEITGRVPKKALGITLIKGIDegPEGLKLISDIIREKMGID--ISVLMGANIANEVAAEKFC 164
Cdd:COG0240  70 GADLVLLAVPSQALREVLEQLAPLLPPGAPVVSATKGIE--PGTGLLMSEVIAEELPGAlrIAVLSGPSFAEEVARGLPT 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999 165 ETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFARIF 244
Cdd:COG0240 148 AVVVASEDEEVAERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGVAL 227

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999 245 ckgQVSTATFLESCGVADLITTCYG--GRNRRVAEAFARtGKTIEELEKEMlnGQKLQGPQTSAEVYRILKQKGLldKFP 322
Cdd:COG0240 228 ---GARPETFMGLAGLGDLVLTCTSdlSRNRRFGLALGK-GKSLEEALAEM--GMVAEGVYTAKAVYELAEKLGV--EMP 299

                       330       340
                ....*....|....*....|....*.
gi 24307999 323 LFTAVYQICYESRPVQEMLSCLQSHP 348
Cdd:COG0240 300 ITEAVYAVLYEGKSPREAVEALMARP 325
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
7-344 1.93e-80

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 248.45  E-value: 1.93e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999    7 KVCIVGSGNWGSAVAKIIGNNVKKlqkfastVKMWVFEETVngrklTDIINNDHENVKYLPGHKLPENVVAMSNLSEAVQ 86
Cdd:PRK00094   3 KIAVLGAGSWGTALAIVLARNGHD-------VTLWARDPEQ-----AAEINADRENPRYLPGIKLPDNLRATTDLAEALA 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999   87 DADLLVFVIPHQFIHRICDEITGRVPKKALGITLIKGIDEGPegLKLISDIIREKMG--IDISVLMGANIANEVAAEKFC 164
Cdd:PRK00094  71 DADLILVAVPSQALREVLKQLKPLLPPDAPIVWATKGIEPGT--GKLLSEVLEEELPdlAPIAVLSGPSFAKEVARGLPT 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999  165 ETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFARIF 244
Cdd:PRK00094 149 AVVIASTDEELAERVQELFHSPYFRVYTNTDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEITRLGVAL 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999  245 -CKgqvsTATFLESCGVADLITTCYG--GRNRRVAEAFARtGKTIEELEKEMlnGQKLQGPQTSAEVYRILKQKGLldKF 321
Cdd:PRK00094 229 gAN----PETFLGLAGLGDLVLTCTSplSRNRRFGLALGQ-GKSLEEALAEI--GMVAEGVRTAKAVYELAKKLGV--EM 299

                        330       340
                 ....*....|....*....|...
gi 24307999  322 PLFTAVYQICYESRPVQEMLSCL 344
Cdd:PRK00094 300 PITEAVYAVLYEGKDPREAVEDL 322
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 195-341 9.79e-63

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 196.46  E-value: 9.79e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999   195 DADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFARIFCKgqvSTATFLESCGVADLITTCYGG--RN 272
Cdd:pfam07479   1 DVIGVELGGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLGKALGA---KPETFFGLAGLGDLIVTCTSGlsRN 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24307999   273 RRVAEAFARtGKTIEELEKEMlnGQKLQGPQTSAEVYRILKQKGLldKFPLFTAVYQICYESRPVQEML 341
Cdd:pfam07479  78 RRFGEALGK-GKSLEEAEKEL--GQVAEGVYTAKAVYELAKKLGV--EMPIFEAVYRILYEGKSPEEAL 141
NAD_Gly3P_dh_N pfam01210
NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent ...
 7-175 2.09e-59

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.


Pssm-ID: 395967 [Multi-domain]  Cd Length: 158  Bit Score: 188.55  E-value: 2.09e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999     7 KVCIVGSGNWGSAVAKIIGNNvkklqkfASTVKMWVFEEtvngrKLTDIINNDHENVKYLPGHKLPENVVAMSNLSEAVQ 86
Cdd:pfam01210   1 KIAVLGAGSWGTALAKVLADN-------GHEVRLWGRDE-----ELIEEINTTHENVRYLPGIKLPENLKATTDLAEALK 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999    87 DADLLVFVIPHQFIHRICDEITGRVPKKALGITLIKGIDEGpeGLKLISDIIREKMGI--DISVLMGANIANEVAAEKFC 164
Cdd:pfam01210  69 GADIIVIVVPSQALREVLKQLKGLLKPDAILVSLSKGIEPG--TLKLLSEVIEEELGIqpPIAVLSGPSHAEEVAQGLPT 146

                         170
                  ....*....|.
gi 24307999   165 ETTIGSKVMEN 175
Cdd:pfam01210 147 ATVIASKDEEA 157
PRK12439 PRK12439
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 1-317 1.02e-45

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 171500 [Multi-domain]  Cd Length: 341  Bit Score: 159.18  E-value: 1.02e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999    1 MAAA--PLKVCIVGSGNWGSAVAKIIGNNVKKLQkfastvkmWV-FEETVNGrkltdiINNDHENVKYLP-GHKLPENVV 76
Cdd:PRK12439   1 MAAAkrEPKVVVLGGGSWGTTVASICARRGPTLQ--------WVrSAETADD------INDNHRNSRYLGnDVVLSDTLR 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999   77 AMSNLSEAVQDADLLVFVIP-HQF---IHRICDEITGRVPKkalgITLIKGIDEGPEglKLISDIIREKM-GIDISVLMG 151
Cdd:PRK12439  67 ATTDFAEAANCADVVVMGVPsHGFrgvLTELAKELRPWVPV----VSLVKGLEQGTN--MRMSQIIEEVLpGHPAGILAG 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999  152 ANIANEVAAEKFCETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIR 231
Cdd:PRK12439 141 PNIAREVAEGYAAAAVLAMPDQHLATRLSPLFRTRRFRVYTTDDVVGVEMAGALKNVFAIAVGMGYSLGIGENTRAMVIA 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999  232 LGLMEMiafARIFCKGQVSTATFLESCGVADLITTCYG--GRNRRVAEAFARtGKTIEELEKEMlnGQKLQGPQTSAEVY 309
Cdd:PRK12439 221 RALREM---TKLGVAMGGNPETFAGLAGMGDLIVTCTSqrSRNRHVGEQLGA-GKPIDEIIASM--NQVAEGVKAASVVM 294


                 ....*...
gi 24307999  310 RILKQKGL 317
Cdd:PRK12439 295 EFADEYGL 302
PRK14618 PRK14618
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 8-349 2.19e-39

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237770 [Multi-domain]  Cd Length: 328  Bit Score: 141.93  E-value: 2.19e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999    8 VCIVGSGNWGSAVAKIignnvkkLQKFASTVKMWVFEETVNGRkltdiINNDHENVKYLPGHKLPENVVAMSNLSEAVQD 87
Cdd:PRK14618   7 VAVLGAGAWGTALAVL-------AASKGVPVRLWARRPEFAAA-----LAAERENREYLPGVALPAELYPTADPEEALAG 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999   88 ADLLVFVIPHQFIHricdEITGRVPKkALGITL-IKGIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAAEKFCET 166
Cdd:PRK14618  75 ADFAVVAVPSKALR----ETLAGLPR-ALGYVScAKGLAPDGGRLSELARVLEFLTQARVAVLSGPNHAEEIARFLPAAT 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999  167 TIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFARIFCK 246
Cdd:PRK14618 150 VVASPEPGLARRVQAAFSGPSFRVYTSRDRVGVELGGALKNVIALAAGMVDGLKLGDNAKAALITRGLREMVRFGVALGA 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999  247 GQvstATFLESCGVADLITTCYG--GRNRRVAEAFARtgktieelekemlnGQKLQGPQTSAEVYRILKQKGLLDKF--- 321
Cdd:PRK14618 230 EE---ATFYGLSGLGDLIATATSphSRNRAAGEAIVR--------------GVDREHLEAGGKVVEGLYTVKALDAWaka 292

                        330       340       350
                 ....*....|....*....|....*....|....
gi 24307999  322 -----PLFTAVYQICY-ESRPVQEMLSCLQSHPE 349
Cdd:PRK14618 293 hghdlPIVEAVARVARgGWDPLAGLRSLMGREAK 326
PRK14620 PRK14620
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 6-346 5.41e-32

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 173083 [Multi-domain]  Cd Length: 326  Bit Score: 122.25  E-value: 5.41e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999    6 LKVCIVGSGNWGSAVAKIIGNNvkklqkfASTVKMWvfeetvnGRKLTDI--INNDHENVKYLPGHKLPENVVAMSNLSE 83
Cdd:PRK14620   1 MKISILGAGSFGTAIAIALSSK-------KISVNLW-------GRNHTTFesINTKRKNLKYLPTCHLPDNISVKSAIDE 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999   84 AVQD-ADLLVFVIPHQFIHRICDEITGRVPKKALGITLI-KGIDEgpEGLKLISDIIREKMGID-ISVLMGANIANEVAA 160
Cdd:PRK14620  67 VLSDnATCIILAVPTQQLRTICQQLQDCHLKKNTPILICsKGIEK--SSLKFPSEIVNEILPNNpIAILSGPSFAKEIAE 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999  161 EKFCETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGlMEMIAF 240
Cdd:PRK14620 145 KLPCSIVLAGQNETLGSSLISKLSNENLKIIYSQDIIGVQIGAALKNIIAIACGIVLGKNLGNNAHAAVITKG-MNEIKT 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999  241 ARIFCKGQVSTATFLESCGVADLITTCYGGRNRRVAEAFA-RTGKTIEELEKEmlNGQKLQGPQTSAEVYRILKQkgLLD 319
Cdd:PRK14620 224 LYSAKNGSIDLNTLIGPSCLGDLILTCTTLHSRNMSFGFKiGNGFNINQILSE--GKSVIEGFSTVKPLISLAKK--LNI 299

                        330       340
                 ....*....|....*....|....*..
gi 24307999  320 KFPLFTAVYQICYESRPVQEMLSCLQS 346
Cdd:PRK14620 300 ELPICESIYNLLYENISLEKTISVILS 326
PRK14619 PRK14619
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 5-344 7.95e-27

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237771 [Multi-domain]  Cd Length: 308  Bit Score: 107.77  E-value: 7.95e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999    5 PLKVCIVGSGNWGSAVAKIIGNNvkklqkfASTVKMWvfeetvnGRKLTDiinndhenvkylpghklpenvvamsNLSEA 84
Cdd:PRK14619   4 PKTIAILGAGAWGSTLAGLASAN-------GHRVRVW-------SRRSGL-------------------------SLAAV 44

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999   85 VQDADLLVFVIPHQFIHRICDEITG-RVPKKALGITLIKGIDegPEGLKLISDIIREKMGI-DISVLMGANIANEVAAEK 162
Cdd:PRK14619  45 LADADVIVSAVSMKGVRPVAEQVQAlNLPPETIIVTATKGLD--PETTRTPSQIWQAAFPNhPVVVLSGPNLSKEIQQGL 122

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999  163 FCETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIafaR 242
Cdd:PRK14619 123 PAATVVASRDLAAAETVQQIFSSERFRVYTNSDPLGTELGGTLKNVIAIAAGVCDGLQLGTNAKAALVTRALPEMI---R 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307999  243 IFCKGQVSTATFLESCGVADLITTCYG--GRNRRVAEAFARtGKTIEE-LEKemLNGQKlQGPQTSAEVYRILKQKGLld 319
Cdd:PRK14619 200 VGTHLGAQTETFYGLSGLGDLLATCTSplSRNYQVGYGLAQ-GKSLEQiLAE--LEGTA-EGVNTANVLVQLAQQQNI-- 273

                        330       340
                 ....*....|....*....|....*
gi 24307999  320 KFPLFTAVYQICYESRPVQEMLSCL 344
Cdd:PRK14619 274 AVPITEQVYRLLQGEITPQQALEEL 298
GPD_NAD_C_bact pfam20618
Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent ...
 258-327 6.54e-07

Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent glycerol-3-phosphate dehydrogenase (GPD) from bacteria and archaea. GPD catalyzes the reversible reduction of dihydroxyacetone phosphate to glycerol-3-phosphate.


Pssm-ID: 466767 [Multi-domain]  Cd Length: 66  Bit Score: 45.95  E-value: 6.54e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24307999   258 CGVADLITTCYGG--RNRRVAEAFARtGKTIEELEKEMLngqkLQGPQTSAEVYRILKQKGLLDkFPLFTAV 327
Cdd:pfam20618   1 AGLGDLVLTCTSDlsRNRTFGLLLGK-GMTLAEAGNGQV----AEGVRTAKAVAAILARAHNVE-MPILEAV 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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