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Conserved domains on  [gi|21327667|ref|NP_056016|]
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ribosome biogenesis protein BOP1 [Homo sapiens]

Protein Classification

WD repeat BOP1/ERB1 family ribosome biogenesis protein( domain architecture ID 12086938)

WD repeat BOP1/ERB1 family ribosome biogenesis protein is a component of a complex that is required for maturation of ribosomal RNAs and formation of the 60S ribosome

CATH:  2.130.10.10
Gene Ontology:  GO:0042254|GO:0003676|GO:0043021|GO:0006364
PubMed:  10322433|30069656|21468892
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BOP1NT pfam08145
BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.
 144-402 1.04e-165

BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.


:

Pssm-ID: 462371  Cd Length: 259  Bit Score: 477.41  E-value: 1.04e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667   144 YDDFPHVGYDLDGRRIYKPlRTRDELDQFLDKMDDPDYWRTVQDPMTGRDLRLTDEQVALVRRLQSGQFGDVGFNPYEPA 223
Cdd:pfam08145   1 YDDYPHIGYDIDGKKIMKP-AKGDALDKFLDSMDDPNAWRTVYDKLTGKDVVLTDEDLELIRRIQKGEFPDAGYDPYEPY 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667   224 VDFFSGDVMIHPVTNRPADKRSFIPSLVEKEKVSRMVHAIKMGWIQPRRPRDPTPSFYDLWAQEDPNAVLGRHKM-HVPA 302
Cdd:pfam08145  80 VEWFTSEDEIHPLSNAPEPKRRFIPSKWEAKKVMKLVRAIRMGRIKPRKPKEEEPKFYDLWADEDETEEERRRRPdHIPA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667   303 PKLALPGHAESYNPPPEYLLSEEERLAWEQQEPGERKLSFLPRKFPSLRAVPAYGRFIQERFERCLDLYLCPRQRKMRVN 382
Cdd:pfam08145 160 PKLPLPGHAESYNPPPEYLPTEEERKKWEEMDPEDRKLNFLPQKYDSLRLVPAYEKFIKERFERCLDLYLCPRVRKNRLN 239

                         250       260
                  ....*....|....*....|
gi 21327667   383 VDPEDLIPKLPRPRDLQPFP 402
Cdd:pfam08145 240 IDPESLLPKLPSPKDLRPFP 259
WD40 COG2319
WD40 repeat [General function prediction only];
408-744 3.35e-38

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.98  E-value: 3.35e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667 408 VYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPV-GGVVKSVAWNPSpavclvaaavedsvlllnpal 486
Cdd:COG2319 115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGhSGAVTSVAFSPD--------------------- 173

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667 487 GDRLVAGSTDQLLsafvppeepplqpARWLEASEEERQVgLRlriCHGKPVTQVTWHGRGDYLAVvlATQGHTqVLIHQL 566
Cdd:COG2319 174 GKLLASGSDDGTV-------------RLWDLATGKLLRT-LT---GHTGAVRSVAFSPDGKLLAS--GSADGT-VRLWDL 233

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667 567 SRRRSQSPFRRSHGQVQRVAFHPARPFLLVASQ-RSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGSYDSKLV 645
Cdd:COG2319 234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAdGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667 646 WFDLDlSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVChgmvynDLLQNPLLvpvKVLKGHvltrDLGVLDVI 725
Cdd:COG2319 314 LWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW------DLATGELL---RTLTGH----TGAVTSVA 379

                       330
                ....*....|....*....
gi 21327667 726 FHPTQPWVFSSGADGTVRL 744
Cdd:COG2319 380 FSPDGRTLASGSADGTVRL 398
 
Name Accession Description Interval E-value
BOP1NT pfam08145
BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.
 144-402 1.04e-165

BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.


Pssm-ID: 462371  Cd Length: 259  Bit Score: 477.41  E-value: 1.04e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667   144 YDDFPHVGYDLDGRRIYKPlRTRDELDQFLDKMDDPDYWRTVQDPMTGRDLRLTDEQVALVRRLQSGQFGDVGFNPYEPA 223
Cdd:pfam08145   1 YDDYPHIGYDIDGKKIMKP-AKGDALDKFLDSMDDPNAWRTVYDKLTGKDVVLTDEDLELIRRIQKGEFPDAGYDPYEPY 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667   224 VDFFSGDVMIHPVTNRPADKRSFIPSLVEKEKVSRMVHAIKMGWIQPRRPRDPTPSFYDLWAQEDPNAVLGRHKM-HVPA 302
Cdd:pfam08145  80 VEWFTSEDEIHPLSNAPEPKRRFIPSKWEAKKVMKLVRAIRMGRIKPRKPKEEEPKFYDLWADEDETEEERRRRPdHIPA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667   303 PKLALPGHAESYNPPPEYLLSEEERLAWEQQEPGERKLSFLPRKFPSLRAVPAYGRFIQERFERCLDLYLCPRQRKMRVN 382
Cdd:pfam08145 160 PKLPLPGHAESYNPPPEYLPTEEERKKWEEMDPEDRKLNFLPQKYDSLRLVPAYEKFIKERFERCLDLYLCPRVRKNRLN 239

                         250       260
                  ....*....|....*....|
gi 21327667   383 VDPEDLIPKLPRPRDLQPFP 402
Cdd:pfam08145 240 IDPESLLPKLPSPKDLRPFP 259
BOP1NT smart01035
BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.
 144-402 1.02e-164

BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.


Pssm-ID: 214986  Cd Length: 264  Bit Score: 475.27  E-value: 1.02e-164
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667    144 YDDFPHVGYDLDGRRIYKPLRTrDELDQFLDKMDDPDYWRTVQDPMTGRDLRLTDEQVALVRRLQSGQFGDVGFNPYEPA 223
Cdd:smart01035   1 YDDYPHIGYDIDGKKIMKPAKG-DALDKFLDSIDDPNFWRTVYDKQTGKDVNLTDEELELIKRIQRGEIPDENYDPYEPY 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667    224 VDFFSGDVMIHPVTNRPADKRSFIPSLVEKEKVSRMVHAIKMGWIQPRRPR------DPTPSFYDLWAQEDPNAVLGRHK 297
Cdd:smart01035  80 VEWFTSEVEIMPLSNAPEPKRRFVPSKHEAKKIMKLVHAIRMGWIKPDKPPkekeeeEEYPKFYDLWADEDETETKFRII 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667    298 MHVPAPKLALPGHAESYNPPPEYLLSEEERLAWEQQEPGERKLSFLPRKFPSLRAVPAYGRFIQERFERCLDLYLCPRQR 377
Cdd:smart01035 160 MHIPAPKLPLPGHAESYNPPPEYLPTEEEKKEWEELEPEDRKLNFLPQKFDSLRKVPGYTNFIKERFERCLDLYLAPRQR 239

                          250       260
                   ....*....|....*....|....*
gi 21327667    378 KMRVNVDPEDLIPKLPRPRDLQPFP 402
Cdd:smart01035 240 RNKLNIDPESLLPKLPSPKDLRPFP 264
WD40 COG2319
WD40 repeat [General function prediction only];
408-744 3.35e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.98  E-value: 3.35e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667 408 VYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPV-GGVVKSVAWNPSpavclvaaavedsvlllnpal 486
Cdd:COG2319 115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGhSGAVTSVAFSPD--------------------- 173

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667 487 GDRLVAGSTDQLLsafvppeepplqpARWLEASEEERQVgLRlriCHGKPVTQVTWHGRGDYLAVvlATQGHTqVLIHQL 566
Cdd:COG2319 174 GKLLASGSDDGTV-------------RLWDLATGKLLRT-LT---GHTGAVRSVAFSPDGKLLAS--GSADGT-VRLWDL 233

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667 567 SRRRSQSPFRRSHGQVQRVAFHPARPFLLVASQ-RSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGSYDSKLV 645
Cdd:COG2319 234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAdGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667 646 WFDLDlSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVChgmvynDLLQNPLLvpvKVLKGHvltrDLGVLDVI 725
Cdd:COG2319 314 LWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW------DLATGELL---RTLTGH----TGAVTSVA 379

                       330
                ....*....|....*....
gi 21327667 726 FHPTQPWVFSSGADGTVRL 744
Cdd:COG2319 380 FSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 408-745 3.86e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 132.07  E-value: 3.86e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667 408 VYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPV-GGVVKSVAWNPSpavclvaaavedsvlllnpal 486
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGhTGPVRDVAASAD--------------------- 62

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667 487 GDRLVAGSTDQLLSafvppeepplqpaRW-LEASEEERQVGlrlriCHGKPVTQVTWHGRGDYLAvvlATQGHTQVLIHQ 565
Cdd:cd00200  63 GTYLASGSSDKTIR-------------LWdLETGECVRTLT-----GHTSYVSSVAFSPDGRILS---SSSRDKTIKVWD 121

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667 566 LSRRRSQSPFRrSH-GQVQRVAFHPARPFLLVASQ-RSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGSYDSK 643
Cdd:cd00200 122 VETGKCLTTLR-GHtDWVNSVAFSPDGTFVASSSQdGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT 200

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667 644 L-VWfdlDLST-KPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVchgmvYNDLLQnpllVPVKVLKGHvltrDLGV 721
Cdd:cd00200 201 IkLW---DLSTgKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRV-----WDLRTG----ECVQTLSGH----TNSV 264

                       330       340
                ....*....|....*....|....
gi 21327667 722 LDVIFHPTQPWVFSSGADGTVRLF 745
Cdd:cd00200 265 TSLAWSPDGKRLASGSADGTIRIW 288
WD40 pfam00400
WD domain, G-beta repeat;
408-441 3.41e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.73  E-value: 3.41e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 21327667   408 VYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWE 441
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 408-441 5.07e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 5.07e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 21327667    408 VYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWE 441
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
BOP1NT pfam08145
BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.
 144-402 1.04e-165

BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.


Pssm-ID: 462371  Cd Length: 259  Bit Score: 477.41  E-value: 1.04e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667   144 YDDFPHVGYDLDGRRIYKPlRTRDELDQFLDKMDDPDYWRTVQDPMTGRDLRLTDEQVALVRRLQSGQFGDVGFNPYEPA 223
Cdd:pfam08145   1 YDDYPHIGYDIDGKKIMKP-AKGDALDKFLDSMDDPNAWRTVYDKLTGKDVVLTDEDLELIRRIQKGEFPDAGYDPYEPY 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667   224 VDFFSGDVMIHPVTNRPADKRSFIPSLVEKEKVSRMVHAIKMGWIQPRRPRDPTPSFYDLWAQEDPNAVLGRHKM-HVPA 302
Cdd:pfam08145  80 VEWFTSEDEIHPLSNAPEPKRRFIPSKWEAKKVMKLVRAIRMGRIKPRKPKEEEPKFYDLWADEDETEEERRRRPdHIPA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667   303 PKLALPGHAESYNPPPEYLLSEEERLAWEQQEPGERKLSFLPRKFPSLRAVPAYGRFIQERFERCLDLYLCPRQRKMRVN 382
Cdd:pfam08145 160 PKLPLPGHAESYNPPPEYLPTEEERKKWEEMDPEDRKLNFLPQKYDSLRLVPAYEKFIKERFERCLDLYLCPRVRKNRLN 239

                         250       260
                  ....*....|....*....|
gi 21327667   383 VDPEDLIPKLPRPRDLQPFP 402
Cdd:pfam08145 240 IDPESLLPKLPSPKDLRPFP 259
BOP1NT smart01035
BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.
 144-402 1.02e-164

BOP1NT (NUC169) domain; This N terminal domain is found in BOP1-like WD40 proteins.


Pssm-ID: 214986  Cd Length: 264  Bit Score: 475.27  E-value: 1.02e-164
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667    144 YDDFPHVGYDLDGRRIYKPLRTrDELDQFLDKMDDPDYWRTVQDPMTGRDLRLTDEQVALVRRLQSGQFGDVGFNPYEPA 223
Cdd:smart01035   1 YDDYPHIGYDIDGKKIMKPAKG-DALDKFLDSIDDPNFWRTVYDKQTGKDVNLTDEELELIKRIQRGEIPDENYDPYEPY 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667    224 VDFFSGDVMIHPVTNRPADKRSFIPSLVEKEKVSRMVHAIKMGWIQPRRPR------DPTPSFYDLWAQEDPNAVLGRHK 297
Cdd:smart01035  80 VEWFTSEVEIMPLSNAPEPKRRFVPSKHEAKKIMKLVHAIRMGWIKPDKPPkekeeeEEYPKFYDLWADEDETETKFRII 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667    298 MHVPAPKLALPGHAESYNPPPEYLLSEEERLAWEQQEPGERKLSFLPRKFPSLRAVPAYGRFIQERFERCLDLYLCPRQR 377
Cdd:smart01035 160 MHIPAPKLPLPGHAESYNPPPEYLPTEEEKKEWEELEPEDRKLNFLPQKFDSLRKVPGYTNFIKERFERCLDLYLAPRQR 239

                          250       260
                   ....*....|....*....|....*
gi 21327667    378 KMRVNVDPEDLIPKLPRPRDLQPFP 402
Cdd:smart01035 240 RNKLNIDPESLLPKLPSPKDLRPFP 264
WD40 COG2319
WD40 repeat [General function prediction only];
408-744 3.35e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.98  E-value: 3.35e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667 408 VYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPV-GGVVKSVAWNPSpavclvaaavedsvlllnpal 486
Cdd:COG2319 115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGhSGAVTSVAFSPD--------------------- 173

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667 487 GDRLVAGSTDQLLsafvppeepplqpARWLEASEEERQVgLRlriCHGKPVTQVTWHGRGDYLAVvlATQGHTqVLIHQL 566
Cdd:COG2319 174 GKLLASGSDDGTV-------------RLWDLATGKLLRT-LT---GHTGAVRSVAFSPDGKLLAS--GSADGT-VRLWDL 233

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667 567 SRRRSQSPFRRSHGQVQRVAFHPARPFLLVASQ-RSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGSYDSKLV 645
Cdd:COG2319 234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAdGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667 646 WFDLDlSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVChgmvynDLLQNPLLvpvKVLKGHvltrDLGVLDVI 725
Cdd:COG2319 314 LWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW------DLATGELL---RTLTGH----TGAVTSVA 379

                       330
                ....*....|....*....
gi 21327667 726 FHPTQPWVFSSGADGTVRL 744
Cdd:COG2319 380 FSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 408-745 3.86e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 132.07  E-value: 3.86e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667 408 VYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPV-GGVVKSVAWNPSpavclvaaavedsvlllnpal 486
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGhTGPVRDVAASAD--------------------- 62

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667 487 GDRLVAGSTDQLLSafvppeepplqpaRW-LEASEEERQVGlrlriCHGKPVTQVTWHGRGDYLAvvlATQGHTQVLIHQ 565
Cdd:cd00200  63 GTYLASGSSDKTIR-------------LWdLETGECVRTLT-----GHTSYVSSVAFSPDGRILS---SSSRDKTIKVWD 121

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667 566 LSRRRSQSPFRrSH-GQVQRVAFHPARPFLLVASQ-RSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGSYDSK 643
Cdd:cd00200 122 VETGKCLTTLR-GHtDWVNSVAFSPDGTFVASSSQdGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT 200

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667 644 L-VWfdlDLST-KPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVchgmvYNDLLQnpllVPVKVLKGHvltrDLGV 721
Cdd:cd00200 201 IkLW---DLSTgKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRV-----WDLRTG----ECVQTLSGH----TNSV 264

                       330       340
                ....*....|....*....|....
gi 21327667 722 LDVIFHPTQPWVFSSGADGTVRLF 745
Cdd:cd00200 265 TSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
405-745 4.05e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.46  E-value: 4.05e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667 405 QALVYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRT-VPVGGVVKSVAWNPSpavclvaaavedsvllln 483
Cdd:COG2319  70 LLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTlTGHTGAVRSVAFSPD------------------ 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667 484 palGDRLVAGSTDQllsafvppeepplqparwleaseeerqvGLRL-RICHGKPVTQVTWHgrgdylavvlatqghtqvl 562
Cdd:COG2319 132 ---GKTLASGSADG----------------------------TVRLwDLATGKLLRTLTGH------------------- 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667 563 ihqlsrrrsqspfrrsHGQVQRVAFHPARPFLLVASQ-RSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGSYD 641
Cdd:COG2319 162 ----------------SGAVTSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSAD 225

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667 642 SKLVWFDLDlSTKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVivchgMVYNdlLQNPLLVpvKVLKGHvltrDLGV 721
Cdd:COG2319 226 GTVRLWDLA-TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV-----RLWD--LATGELL--RTLTGH----SGGV 291

                       330       340
                ....*....|....*....|....
gi 21327667 722 LDVIFHPTQPWVFSSGADGTVRLF 745
Cdd:COG2319 292 NSVAFSPDGKLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
513-745 1.76e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.43  E-value: 1.76e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667 513 ARWLEASEEERQVGLRLRICHGKPVTQVTWHGRGDYLAVVLATQGHTQVLIHQLSRRRsqsPFRRSHGQVQRVAFHPARP 592
Cdd:COG2319  15 DLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLA---TLLGHTAAVLSVAFSPDGR 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667 593 FLLVAS-QRSVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGSYDSKLVWFDLDlSTKPYRMLRHHKKALRAVAF 671
Cdd:COG2319  92 LLASASaDGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA-TGKLLRTLTGHSGAVTSVAF 170

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21327667 672 HPRYPLFASGSDDGSVIVChgmvynDLLQNPLLvpvKVLKGHvltrDLGVLDVIFHPTQPWVFSSGADGTVRLF 745
Cdd:COG2319 171 SPDGKLLASGSDDGTVRLW------DLATGKLL---RTLTGH----TGAVRSVAFSPDGKLLASGSADGTVRLW 231
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 655-745 1.85e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.66  E-value: 1.85e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667 655 PYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIVChgmvynDLLQNPLLvpvKVLKGHvltrDLGVLDVIFHPTQPWVF 734
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVW------DLETGELL---RTLKGH----TGPVRDVAASADGTYLA 67

                        90
                ....*....|.
gi 21327667 735 SSGADGTVRLF 745
Cdd:cd00200  68 SGSSDKTIRLW 78
WD40 pfam00400
WD domain, G-beta repeat;
408-441 3.41e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.73  E-value: 3.41e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 21327667   408 VYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWE 441
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 408-441 5.07e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 5.07e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 21327667    408 VYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWE 441
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
408-444 2.22e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 53.76  E-value: 2.22e-07
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 21327667 408 VYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVAT 444
Cdd:COG2319 367 TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 408-441 2.75e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.64  E-value: 2.75e-06
                        10        20        30
                ....*....|....*....|....*....|....
gi 21327667 408 VYRGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWE 441
Cdd:cd00200 256 TLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 652-689 6.11e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 6.11e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 21327667    652 STKPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIV 689
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKL 38
WD40 pfam00400
WD domain, G-beta repeat;
654-689 3.53e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 3.53e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 21327667   654 KPYRMLRHHKKALRAVAFHPRYPLFASGSDDGSVIV 689
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
WD40 pfam00400
WD domain, G-beta repeat;
706-745 9.70e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 9.70e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 21327667   706 PVKVLKGHvltrDLGVLDVIFHPTQPWVFSSGADGTVRLF 745
Cdd:pfam00400   3 LLKTLEGH----TGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 706-745 1.68e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.68e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 21327667    706 PVKVLKGHvltrDLGVLDVIFHPTQPWVFSSGADGTVRLF 745
Cdd:smart00320   4 LLKTLKGH----TGPVTSVAFSPDGKYLASGSDDGTIKLW 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 397-463 8.01e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.18  E-value: 8.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21327667   397 DLQPFPTC--QALVYR------------GHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVG-GVVKSVA 461
Cdd:pfam12894   8 DLIALATEdgELLLHRlnwqrvwtlspdKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGsDLITCLG 87


                  ..
gi 21327667   462 WN 463
Cdd:pfam12894  88 WG 89
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 410-446 5.16e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 39.67  E-value: 5.16e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 21327667   410 RGHSDLVRCLSVSPGGQWLVSGSDDGSLRLWEVATAR 446
Cdd:pfam20426 121 RQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGR 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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