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Conserved domains on  [gi|149363685|ref|NP_056140|]
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little elongation complex subunit 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mplasa_alph_rch super family cl37461
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 25-193 2.48e-06

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


The actual alignment was detected with superfamily member TIGR04523:

Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 52.72  E-value: 2.48e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685    25 SLQQNLNEYVEALITLKQkiiNTDNLLTEYQKKCDELQFARRENSNLHHQVEEMLQKISPLQKCQEELGSLKAELEEKKS 104
Cdd:TIGR04523  465 SLETQLKVLSRSINKIKQ---NLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKIS 541

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685   105 SLklyqdthqeyarvKEECLKSDaqkkkLEAKVKKLQEAAVKQTQDFKQLRNEKKILEKEFKKTQERLDEFSKQKNE--K 182
Cdd:TIGR04523  542 DL-------------EDELNKDD-----FELKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDliK 603

                          170
                   ....*....|.
gi 149363685   183 ELRHIGTQISS 193
Cdd:TIGR04523  604 EIEEKEKKISS 614
 
Name Accession Description Interval E-value
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 25-193 2.48e-06

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 52.72  E-value: 2.48e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685    25 SLQQNLNEYVEALITLKQkiiNTDNLLTEYQKKCDELQFARRENSNLHHQVEEMLQKISPLQKCQEELGSLKAELEEKKS 104
Cdd:TIGR04523  465 SLETQLKVLSRSINKIKQ---NLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKIS 541

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685   105 SLklyqdthqeyarvKEECLKSDaqkkkLEAKVKKLQEAAVKQTQDFKQLRNEKKILEKEFKKTQERLDEFSKQKNE--K 182
Cdd:TIGR04523  542 DL-------------EDELNKDD-----FELKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDliK 603

                          170
                   ....*....|.
gi 149363685   183 ELRHIGTQISS 193
Cdd:TIGR04523  604 EIEEKEKKISS 614
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
24-185 8.77e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 50.92  E-value: 8.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685   24 ASLQQNLNEYVEALITLKQKIINTDNLLTEYQKKCD------ELQFARRENSNLHHQVEEMLQKISPLQKCQEELGSLKA 97
Cdd:COG4717    91 AELQEELEELEEELEELEAELEELREELEKLEKLLQllplyqELEALEAELAELPERLEELEERLEELRELEEELEELEA 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685   98 ELEEKKSSL--KLYQDTHQEYARVKEecLKSDAQkkkleakvkKLQEAAVKQTQDFKQLRNEKKILEKEFKKTQERLDEF 175
Cdd:COG4717   171 ELAELQEELeeLLEQLSLATEEELQD--LAEELE---------ELQQRLAELEEELEEAQEELEELEEELEQLENELEAA 239

                         170
                  ....*....|
gi 149363685  176 SKQKNEKELR 185
Cdd:COG4717   240 ALEERLKEAR 249
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
30-183 2.24e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 46.60  E-value: 2.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685   30 LNEYVEALITLKQKIINTDNLLTEYQKKCDELQFARRENSNLHHQVEEMLQKISPLQKCQEELGSLKAELEEKKSSLKLY 109
Cdd:PRK03918  278 LEEKVKELKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEEL 357

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 149363685  110 QDTHQEYARVKEecLKSDAQKKKLEAKVKKLQEAAVKqtqdFKQLRNEKKILEKEFKKTQERLDEFSKQKNEKE 183
Cdd:PRK03918  358 EERHELYEEAKA--KKEELERLKKRLTGLTPEKLEKE----LEELEKAKEEIEEEISKITARIGELKKEIKELK 425
IFT57 pfam10498
Intra-flagellar transport protein 57; Eukaryotic cilia and flagella are specialized organelles ...
 26-106 8.97e-04

Intra-flagellar transport protein 57; Eukaryotic cilia and flagella are specialized organelles found at the periphery of cells of diverse organizms. Intra-flagellar transport (IFT) is required for the assembly and maintenance of eukaryotic cilia and flagella, and consists of the bidirectional movement of large protein particles between the base and the distal tip of the organelle. IFT particles contain multiple copies of two distinct protein complexes, A and B, which contain at least 6 and 11 protein subunits. IFT57 is part of complex B but is not, however, required for the core subunits to stay associated. This protein is known as Huntington-interacting protein-1 in humans.


Pssm-ID: 463118 [Multi-domain]  Cd Length: 360  Bit Score: 44.17  E-value: 8.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685    26 LQQNLNEYVEALITlKQKIINT--DNLLTEYQKKCDELQFARRENSNLHHQVEEMLQKispLQKCQEELGSLKAELEEKK 103
Cdd:pfam10498  248 LHTDISKTLEKIES-REKYINSqlEPLIQEYREAQDELSEVQEKYKQLSEGVTERTRE---LAEITEELEKVKQEMEERG 323


                   ...
gi 149363685   104 SSL 106
Cdd:pfam10498  324 SSM 326
 
Name Accession Description Interval E-value
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 25-193 2.48e-06

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 52.72  E-value: 2.48e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685    25 SLQQNLNEYVEALITLKQkiiNTDNLLTEYQKKCDELQFARRENSNLHHQVEEMLQKISPLQKCQEELGSLKAELEEKKS 104
Cdd:TIGR04523  465 SLETQLKVLSRSINKIKQ---NLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKIS 541

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685   105 SLklyqdthqeyarvKEECLKSDaqkkkLEAKVKKLQEAAVKQTQDFKQLRNEKKILEKEFKKTQERLDEFSKQKNE--K 182
Cdd:TIGR04523  542 DL-------------EDELNKDD-----FELKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDliK 603

                          170
                   ....*....|.
gi 149363685   183 ELRHIGTQISS 193
Cdd:TIGR04523  604 EIEEKEKKISS 614
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
24-185 8.77e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 50.92  E-value: 8.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685   24 ASLQQNLNEYVEALITLKQKIINTDNLLTEYQKKCD------ELQFARRENSNLHHQVEEMLQKISPLQKCQEELGSLKA 97
Cdd:COG4717    91 AELQEELEELEEELEELEAELEELREELEKLEKLLQllplyqELEALEAELAELPERLEELEERLEELRELEEELEELEA 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685   98 ELEEKKSSL--KLYQDTHQEYARVKEecLKSDAQkkkleakvkKLQEAAVKQTQDFKQLRNEKKILEKEFKKTQERLDEF 175
Cdd:COG4717   171 ELAELQEELeeLLEQLSLATEEELQD--LAEELE---------ELQQRLAELEEELEEAQEELEELEEELEQLENELEAA 239

                         170
                  ....*....|
gi 149363685  176 SKQKNEKELR 185
Cdd:COG4717   240 ALEERLKEAR 249
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 24-181 1.34e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 47.36  E-value: 1.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685    24 ASLQQNLNEYVEALITLKQKIintDNLLTEYQKKCDELQFARRENSNLHHQVEEMLQKISPLQKCQEELGSLKAELEEKK 103
Cdd:TIGR02168  855 ESLAAEIEELEELIEELESEL---EALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRL 931

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685   104 SSLKLYQDTHQEYARVKEEcLKSDAQKKKLEAKVKKLQEAAvkqtQDFKQLRNEKKIL-------EKEFKKTQERLDEFS 176
Cdd:TIGR02168  932 EGLEVRIDNLQERLSEEYS-LTLEEAEALENKIEDDEEEAR----RRLKRLENKIKELgpvnlaaIEEYEELKERYDFLT 1006


                   ....*
gi 149363685   177 KQKNE 181
Cdd:TIGR02168 1007 AQKED 1011
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 41-210 2.19e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 46.55  E-value: 2.19e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685    41 KQKIINTDNLLTEYQKKCDELQFARRENSNLHHQVEEMLQKISPLQKCQEELGSLKAELEEKKSSLKLyqdthqEYARVK 120
Cdd:TIGR04523  408 QQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSR------SINKIK 481

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685   121 EEclksdaqkkkleakVKKLQEAAVKQTQDFKQLRNEKKILEKEFKKTQERLDEF-SKQKN-EKELRHIGTQISS--DSY 196
Cdd:TIGR04523  482 QN--------------LEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLkEKIEKlESEKKEKESKISDleDEL 547

                          170
                   ....*....|....
gi 149363685   197 GSIDKRKVKLLLKE 210
Cdd:TIGR04523  548 NKDDFELKKENLEK 561
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
30-183 2.24e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 46.60  E-value: 2.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685   30 LNEYVEALITLKQKIINTDNLLTEYQKKCDELQFARRENSNLHHQVEEMLQKISPLQKCQEELGSLKAELEEKKSSLKLY 109
Cdd:PRK03918  278 LEEKVKELKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEEL 357

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 149363685  110 QDTHQEYARVKEecLKSDAQKKKLEAKVKKLQEAAVKqtqdFKQLRNEKKILEKEFKKTQERLDEFSKQKNEKE 183
Cdd:PRK03918  358 EERHELYEEAKA--KKEELERLKKRLTGLTPEKLEKE----LEELEKAKEEIEEEISKITARIGELKKEIKELK 425
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 23-192 2.71e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 46.20  E-value: 2.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685    23 CASLQQNLNEYVEALITLKQKIINTDNLLTEYQKKCDEL-----------QFARRENSNLHHQVEEMLQKISPLQKCQEE 91
Cdd:TIGR02168  255 LEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALaneisrleqqkQILRERLANLERQLEELEAQLEELESKLDE 334

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685    92 LGSLKAELEEKKSSLKlyqdthQEYARVKEECLKSDAQKKKLEAKVKKLQEAAVKQTQDFKQLRNE-------------- 157
Cdd:TIGR02168  335 LAEELAELEEKLEELK------EELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQiaslnneierlear 408

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 149363685   158 KKILEKEFKKTQERLDEFSKQKNEKELRHIGTQIS 192
Cdd:TIGR02168  409 LERLEDRRERLQQEIEELLKKLEEAELKELQAELE 443
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 35-210 2.96e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 46.21  E-value: 2.96e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685    35 EALITLKQKIintDNLLTEYQKKCDELQFARRENSNLHHQVEEMLQKISPLQKCQEELGSLKAELEEKKSslklyqDTHQ 114
Cdd:TIGR02169  357 EEYAELKEEL---EDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELA------DLNA 427

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685   115 EYARVKEECLKSDAQkkkleakVKKLQEAAVKQTQDFKQLRNEKKILEKEFKKTQERLDEFSKQ--KNEKELRHIGTQIS 192
Cdd:TIGR02169  428 AIAGIEAKINELEEE-------KEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKElsKLQRELAEAEAQAR 500

                          170
                   ....*....|....*...
gi 149363685   193 SDSYGSIDKRKVKLLLKE 210
Cdd:TIGR02169  501 ASEERVRGGRAVEEVLKA 518
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 6-185 3.89e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.82  E-value: 3.89e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685     6 THSAAPGTAADLSRCQGCASLQQNLNEYVEALITLKQKIINTDNLLTEYQKKCDELQFARRENSNLHHQVEEMLQKIS-P 84
Cdd:TIGR02168  662 TGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEaE 741

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685    85 LQKCQEELGSLKAELEEKKSSLKLYQDTHQEYARVKEEClksDAQKKKLEAKVKKLQEAAVKQTQDFKQLRNEKKILEKE 164
Cdd:TIGR02168  742 VEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEA---EAEIEELEAQIEQLKEELKALREALDELRAELTLLNEE 818

                          170       180
                   ....*....|....*....|.
gi 149363685   165 FKKTQERLDEFSKQKNEKELR 185
Cdd:TIGR02168  819 AANLRERLESLERRIAATERR 839
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
24-211 4.86e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 44.89  E-value: 4.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685   24 ASLQQNLNEYVEALITLKQKIINT----DNLLTEYQKKCDELQFARRENSNLHHQVEEMLQKispLQKCQEELGSLKAEL 99
Cdd:COG4372    27 AALSEQLRKALFELDKLQEELEQLreelEQAREELEQLEEELEQARSELEQLEEELEELNEQ---LQAAQAELAQAQEEL 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685  100 EEKKSSlklYQDTHQEYARVKEECLKSDAQKKKLEAKVKKLQEAAVKQTQDFKQLRNEKKILEKEFKKTQERLDEFSKQK 179
Cdd:COG4372   104 ESLQEE---AEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAE 180

                         170       180       190
                  ....*....|....*....|....*....|..
gi 149363685  180 NEKELRHIGTQISSDSYGSIDKRKVKLLLKEL 211
Cdd:COG4372   181 AEQALDELLKEANRNAEKEEELAEAEKLIESL 212
IFT57 pfam10498
Intra-flagellar transport protein 57; Eukaryotic cilia and flagella are specialized organelles ...
 26-106 8.97e-04

Intra-flagellar transport protein 57; Eukaryotic cilia and flagella are specialized organelles found at the periphery of cells of diverse organizms. Intra-flagellar transport (IFT) is required for the assembly and maintenance of eukaryotic cilia and flagella, and consists of the bidirectional movement of large protein particles between the base and the distal tip of the organelle. IFT particles contain multiple copies of two distinct protein complexes, A and B, which contain at least 6 and 11 protein subunits. IFT57 is part of complex B but is not, however, required for the core subunits to stay associated. This protein is known as Huntington-interacting protein-1 in humans.


Pssm-ID: 463118 [Multi-domain]  Cd Length: 360  Bit Score: 44.17  E-value: 8.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685    26 LQQNLNEYVEALITlKQKIINT--DNLLTEYQKKCDELQFARRENSNLHHQVEEMLQKispLQKCQEELGSLKAELEEKK 103
Cdd:pfam10498  248 LHTDISKTLEKIES-REKYINSqlEPLIQEYREAQDELSEVQEKYKQLSEGVTERTRE---LAEITEELEKVKQEMEERG 323


                   ...
gi 149363685   104 SSL 106
Cdd:pfam10498  324 SSM 326
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
28-177 1.29e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 43.90  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685   28 QNLNEYVEALITLKQKIINTDNLLTEYQKKCDELQFARRENSNLHHQVEEMLQKISPLQKCQEELGSLKAELEEKKSSLK 107
Cdd:PRK03918  207 REINEISSELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELK 286

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 149363685  108 LYQDTHQEYARVKE---ECLKSDAQKKKLEAKVKKLQEAAVKQTQDFKQLRNEKKILEKEFKKTQERLDEFSK 177
Cdd:PRK03918  287 ELKEKAEEYIKLSEfyeEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEE 359
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 64-175 2.67e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 42.89  E-value: 2.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685   64 ARRENSNLHHQVEEMLQKISPLQKCQE-----------ELGSLKAELEEKKSSL-----KLYQDTHQEYARVKEECLKSD 127
Cdd:PRK00409  507 AKKLIGEDKEKLNELIASLEELERELEqkaeeaeallkEAEKLKEELEEKKEKLqeeedKLLEEAEKEAQQAIKEAKKEA 586

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 149363685  128 AQKKKLEAKVKKLQEAAVK--QTQD-FKQLRNEKKILEKEFKKTQERLDEF 175
Cdd:PRK00409  587 DEIIKELRQLQKGGYASVKahELIEaRKRLNKANEKKEKKKKKQKEKQEEL 637
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 51-211 4.74e-03

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 42.02  E-value: 4.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685    51 LTEYQKKCDELQFARRENSNLHHQVEEMLQKISP-LQKCQEELGSLKAELEEKKSSLK-------------------LYQ 110
Cdd:pfam05483  249 ITEKENKMKDLTFLLEESRDKANQLEEKTKLQDEnLKELIEKKDHLTKELEDIKMSLQrsmstqkaleedlqiatktICQ 328

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685   111 DTHQEYARVkEECLKSDAQKK----KLEAKVKKLQEAAVKQTQDFKQLRNEKKILEKEFKKTQERLDEFSKQKNEK--EL 184
Cdd:pfam05483  329 LTEEKEAQM-EELNKAKAAHSfvvtEFEATTCSLEELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKFKNNKevEL 407

                          170       180
                   ....*....|....*....|....*..
gi 149363685   185 RHIGTQISSDSYGSIDKRKVKLLLKEL 211
Cdd:pfam05483  408 EELKKILAEDEKLLDEKKQFEKIAEEL 434
PYST-B TIGR01597
Plasmodium yoelii subtelomeric family PYST-B; This model represents a paralogous family of ...
 27-181 5.22e-03

Plasmodium yoelii subtelomeric family PYST-B; This model represents a paralogous family of Plasmodium yoelii genes preferentially located in the subtelomeric regions of the chromosomes. There are no obvious homologs to these genes in any other organism.


Pssm-ID: 130658  Cd Length: 255  Bit Score: 41.03  E-value: 5.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685    27 QQNLNEYVEALITLKqkiintdNLLTEYQKKCDELQFAR----------RENSNLH--HQVEEMLQKIspLQKCQEELGS 94
Cdd:TIGR01597   54 QFDLNEFYQSTLSLA-------NQFNDCNDDDKEIAHLRniidshikkhKERNTLPdlNNVDKKTKKL--INKLQKELEE 124

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685    95 LKAELEEKKSSLKLYQDTHQEYARVKEEclksdaqkkkleakvkklqEAAVKQTQDFKQLRNEKKILEKEFKKTQERLDE 174
Cdd:TIGR01597  125 LKKELDNEMNDELTIQPIHDKIIIKKDE-------------------NNSVSEHEDFKQLENEKNSSVSEHEEFDIASSD 185


                   ....*..
gi 149363685   175 FSKQKNE 181
Cdd:TIGR01597  186 NLKIKRK 192
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 91-185 5.22e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 42.35  E-value: 5.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685    91 ELGSLKAELEEKKSSLKLYQDTHQEYARVKEEClksDAQKKKLEAKVKKLQEAAVKQTQDFKQLRNEKKILEKEFKKTQE 170
Cdd:TIGR02168  233 RLEELREELEELQEELKEAEEELEELTAELQEL---EEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRE 309

                           90
                   ....*....|....*
gi 149363685   171 RLDEFSKQKNEKELR 185
Cdd:TIGR02168  310 RLANLERQLEELEAQ 324
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
24-185 6.95e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 41.05  E-value: 6.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685   24 ASLQQNLNEyVEALITLKQKIintDNLLTEYQKKcdelqfaRRENSNLHHQVEEMLQKIsplQKCQEELGSLKAELEEKK 103
Cdd:COG1340   143 KELEKELEK-AKKALEKNEKL---KELRAELKEL-------RKEAEEIHKKIKELAEEA---QELHEEMIELYKEADELR 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685  104 SSLKLYqdtHQEYarvkeeclksdaqkkkleakvKKLQEAAVKQTQDFKQLRNEKKILEKEFKKTQERLDEFSKQKNEKE 183
Cdd:COG1340   209 KEADEL---HKEI---------------------VEAQEKADELHEEIIELQKELRELRKELKKLRKKQRALKREKEKEE 264


                  ..
gi 149363685  184 LR 185
Cdd:COG1340   265 LE 266
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 25-186 7.48e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 41.54  E-value: 7.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685    25 SLQQNLNEYVEALITLKQKIINT----DNLLTEYQKKCDELQFARRENSNLHHQVEEMLQKISPL--QKCQEELGSLKAE 98
Cdd:TIGR04523  236 KKQQEINEKTTEISNTQTQLNQLkdeqNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLnnQKEQDWNKELKSE 315

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149363685    99 LEEKKSSL-----------KLYQDTHQEYARVKEEC-------LKSDAQKKKLEAKVKKLQEAAVKQTQDFKQLRNEKKI 160
Cdd:TIGR04523  316 LKNQEKKLeeiqnqisqnnKIISQLNEQISQLKKELtnsesenSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQIND 395

                          170       180       190
                   ....*....|....*....|....*....|...
gi 149363685   161 LEKEFKKT-------QERLDEFSKQKNEKELRH 186
Cdd:TIGR04523  396 LESKIQNQeklnqqkDEQIKKLQQEKELLEKEI 428
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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