BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 2 (KCTD2); KCTD2 is a BTB/POZ domain-containing protein that functions as an adaptor of Cullin3 E3 ubiquitin ligase. It suppresses gliomagenesis by destabilizing c-Myc. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domain, highly similar to KCTD2, form pentamer structures.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829365  72 RWVRLNVGGTYFVTTRQTLGREPKSFLCRLCcQEDPELDSDKDETGAYLIDRDPTYFGPILNYLRHGKLIITKELAEEGV 151
Cdd:cd18389   1 KWVRLNVGGTYFVSTKQTLCRDPKSFLYRLC-QEDPDLDSDKDETGAYLIDRDPTYFGPILNYLRHGKLIINKELAEEGV 79

                        90       100
                ....*....|....*....|....*.
gi 53829365 152 LEEAEFYNIASLVRLVKERIRDNENR 177
Cdd:cd18389  80 LEEAEFYNIASLVRLVKERIRDNENR 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 2 (KCTD2); KCTD2 is a BTB/POZ domain-containing protein that functions as an adaptor of Cullin3 E3 ubiquitin ligase. It suppresses gliomagenesis by destabilizing c-Myc. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domain, highly similar to KCTD2, form pentamer structures.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829365  72 RWVRLNVGGTYFVTTRQTLGREPKSFLCRLCcQEDPELDSDKDETGAYLIDRDPTYFGPILNYLRHGKLIITKELAEEGV 151
Cdd:cd18389   1 KWVRLNVGGTYFVSTKQTLCRDPKSFLYRLC-QEDPDLDSDKDETGAYLIDRDPTYFGPILNYLRHGKLIINKELAEEGV 79

                        90       100
                ....*....|....*....|....*.
gi 53829365 152 LEEAEFYNIASLVRLVKERIRDNENR 177
Cdd:cd18389  80 LEEAEFYNIASLVRLVKERIRDNENR 105

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829365     73 WVRLNVGGTYFVTTRQTLGREPKSFLCRLCCQEDpeldsDKDETGAYLIDRDPTYFGPILNYLRHGKLIITKELAEEgVL 152
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFK-----ESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEE-LL 74

                           90       100
                   ....*....|....*....|...
gi 53829365    153 EEAEFYNIASLVRLVKERIRDNE 175
Cdd:smart00225  75 ELADYLQIPGLVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 2 (KCTD2); KCTD2 is a BTB/POZ domain-containing protein that functions as an adaptor of Cullin3 E3 ubiquitin ligase. It suppresses gliomagenesis by destabilizing c-Myc. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domain, highly similar to KCTD2, form pentamer structures.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829365  72 RWVRLNVGGTYFVTTRQTLGREPKSFLCRLCcQEDPELDSDKDETGAYLIDRDPTYFGPILNYLRHGKLIITKELAEEGV 151
Cdd:cd18389   1 KWVRLNVGGTYFVSTKQTLCRDPKSFLYRLC-QEDPDLDSDKDETGAYLIDRDPTYFGPILNYLRHGKLIINKELAEEGV 79

                        90       100
                ....*....|....*....|....*.
gi 53829365 152 LEEAEFYNIASLVRLVKERIRDNENR 177
Cdd:cd18389  80 LEEAEFYNIASLVRLVKERIRDNENR 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, and similar proteins; This subfamily includes potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, all of which function as adaptors of Cullin3 based ubiquitin E3 ubiquitin ligases. KCTD2 suppresses gliomagenesis by destabilizing c-Myc. KCTD5 is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. KCTD17 polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domains form pentamer structures.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829365  73 WVRLNVGGTYFVTTRQTLGREPKSFLCRLCcQEDPELDSDKDETGAYLIDRDPTYFGPILNYLRHGKLIITKELAEEGVL 152
Cdd:cd18362   1 WVKLNVGGTYFLTTRTTLCRDPKSFLCRLC-QEDPDLPSDKDETGAYLIDRDPTYFGPILNYLRHGKLIIDKDLAEEGVL 79

                ....*.
gi 53829365 153 EEAEFY 158
Cdd:cd18362  80 EEAEFY 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 9 (KCTD9); KCTD9 is a BTB/POZ domain-containing protein that contributes to liver injury through NK cell activation during hepatitis B virus-induced acute-on-chronic liver failure. It functions as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD9 BTB domain forms a pentameric structure.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829365  72 RWVRLNVGGTYFVTTRQTL-GREPKSFLCRLCcQEDPELDSDKDETGAYLIDRDPTYFGPILNYLRHGKLIITKELAEEG 150
Cdd:cd18368   1 DWIKLNVGGRIFTTTRSTLvKKEPDSMLARMF-SDDSTWPSSRDENGAYLIDRSPEYFEPILNYLRHGQLILNDGLNPLG 79

                        90
                ....*....|....
gi 53829365 151 VLEEAEFYNIASLV 164
Cdd:cd18368  80 VLEEAKFFGIQSLI 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins; This family includes two protein groups: voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins. Kv channels are membrane proteins with fundamental physiological roles. They are responsible for a variety of electrical phenomena, such as the repolarization of the action potential, spike frequency adaptation, synaptic repolarization, and smooth muscle contraction. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels, and others. All family members contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829365  74 VRLNVGGTYFVTTRQTLGREPKSFLCRLCCQEdpELDSDKDETGAYLIDRDPTYFGPILNYLRHGKLIITKELAEEGVLE 153
Cdd:cd18187   1 VVLNVSGTRFVTNRQTLTRHPDTLLGRMFKPG--REFTFPNETGEYFIDRDPTVFRTILNYYRTGKLNCPDGISIPDLRE 78

                ....*
gi 53829365 154 EAEFY 158
Cdd:cd18187  79 ECDFY 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in SH3KBP1-binding protein 1 (SHKBP1); SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829365  74 VRLNVGGTYFVTTRQTLGREPKSFLCRLCCQEDPELdsdKDETGAYLIDRDPTYFGPILNYLRhgkliiTKELAEEGV-- 151
Cdd:cd18393   4 IHLNVGGKRFSTSRQTLTWIPDSFFSSLLSGRISTL---KDETGAIFIDRDPTVFAPILNFLR------TKELDPRGIhv 74

                        90       100       110
                ....*....|....*....|....*....|.
gi 53829365 152 ---LEEAEFYNIASLVRlvKERIRDNENRTS 179
Cdd:cd18393  75 sllLHEAQFYGITPLVR--RLQLCEELDRSS 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3); KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829365  74 VRLNVGGTYFVTTRQTLGREPKSFLCRLCcqeDPELDSDKDETGAYLIDRDPTYFGPILNYLRhgkliiTKELAEEGV-- 151
Cdd:cd18392   4 IQLNVGGTRFSTSRQTLMWIPDSFFSSLL---SGRISSLKDETGAIFIDRDPTAFVPILNFLR------TKELDLRGVni 74

                        90
                ....*....|...
gi 53829365 152 ---LEEAEFYNIA 161
Cdd:cd18392  75 nvlRHEAEFYGIT 87

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829365     73 WVRLNVGGTYFVTTRQTLGREPKSFLCRLCCQEDpeldsDKDETGAYLIDRDPTYFGPILNYLRHGKLIITKELAEEgVL 152
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFK-----ESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEE-LL 74

                           90       100
                   ....*....|....*....|...
gi 53829365    153 EEAEFYNIASLVRLVKERIRDNE 175
Cdd:smart00225  75 ELADYLQIPGLVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 7 (KCTD7); KCTD7 is a BTB/POZ domain-containing protein that has an impact on K+ fluxes, neurotransmitter synthesis, and neuronal function. It functions as a regulator of potassium conductance in neurons, and is involved in the control of excitability of cortical neurons. Mutations in KCTD7 may cause progressive myoclonus epilepsy (PME). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829365  74 VRLNVGGTYFVTTRQTLGREPKSFLCRLCCQEDpelDSDKDETGAYLIDRDPTYFGPILNYLRHGKLiITKELAEEgVLE 153
Cdd:cd18366   6 VPLNVGGMHFTTRLSTLRKYEDSMLAAMFSGRH---HIPKDSEGRYFIDRDGSYFGYILNFLRDGDL-PPRERARA-VYK 80

                        90
                ....*....|.
gi 53829365 154 EAEFYNIASLV 164
Cdd:cd18366  81 EAQYYGIGPLI 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD6, KCTD21 and similar proteins; KCTD6, also called KCASH3 (KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 3), is a substrate-specific adaptor of cullin-3, effectively regulating protein levels of the muscle small ankyrin-1 isoform 5 (sAnk1.5). KCTD21, also called KCASH2, functions as a substrate-specific adaptor of cullin-3, promoting the ubiquitination and degradation of histone deacetylase HDAC1, thereby inhibiting the deacetylation-mediated transcriptional activation of the Hedgehog effectors Gli1 and Gli2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829365  74 VRLNVGGTYFVTTRQTLGREPKSFLCRLCCQEDPeldSDKDETGAYLIDRDPTYFGPILNYLRHGKLIITKELAEEGVLE 153
Cdd:cd18365   3 VNLNVGGVHYTTTLATLTRFPDSMLGAMFSGSMP---TTRDDQGNYFIDRDGTLFRYILNFLRSSQLSLPEDFKEYDLLL 79

                        90
                ....*....|..
gi 53829365 154 -EAEFYNIASLV 164
Cdd:cd18365  80 rEADFYQIEPLI 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel regulatory protein (KCNRG); KCNRG, also called potassium channel regulator or protein CLLD4, is an endoplasmic reticulum (ER)-associated tumor suppressor that regulates Kv1 family potassium channel proteins by retaining a fraction of the channels in endomembranes. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829365  74 VRLNVGGTYFVTTRQTLGREPKSFLCRLCCQEDPELdsdKDETGAYLIDRDPTYFGPILNYLRHGKLIITKELAE-EGVL 152
Cdd:cd18375   3 VTLNVGGKKFTTRPSTLRRFPDSRLARMLDGKDQDF---KVVNGQFFVDRDGSLFSYILDYLRTGQLTLPTEFSDyNRLA 79

                        90
                ....*....|....*
gi 53829365 153 EEAEFYNIASLVRLV 167
Cdd:cd18375  80 REAEFYGLYSLADLL 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD1 and KCTD15; This subfamily of KCTD proteins includes KCTD1 and KCTD15. KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829365  74 VRLNVGGTYFVTTRQTLGREPKSFLCRLCCQEDP-ELDSDKDEtgaYLIDRDPTYFGPILNYLRHGKLIITKELAE-EGV 151
Cdd:cd18361   1 VHIDVGGHIYTSSLETLTKYPESRLGKLFNGSIPiVLDSLKQH---YFIDRDGKMFRHILNFLRTSKLLLPDDFTEfDLL 77

                        90
                ....*....|....
gi 53829365 152 LEEAEFYNIASLVR 165
Cdd:cd18361  78 YEEARYYELQPMVK 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 21 (KCTD21); KCTD21, also calledz KCTD containing, Cullin3 adaptor, suppressor of Hedgehog 2 (KCASH2), is a BTB/POZ domain-containing protein that functions as a substrate-specific adaptor of cullin-3, promoting the ubiquitination and degradation of histone deacetylase HDAC1, thereby inhibiting the deacetylation-mediated transcriptional activation of the Hedgehog effectors Gli1 and Gli2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829365  74 VRLNVGGTYFVTTRQTLGREPKSFLCRLCCQEDPeldSDKDETGAYLIDRDPTYFGPILNYLRHGKLIITKELAEEGVLE 153
Cdd:cd18395   3 ITLNVGGKLYTTSLATLTRYPDSMLGAMFSGKFP---TKKDSQGNCFIDRDGKIFRYILNFLRTSHLDLPEDFQEMGLLK 79

                        90
                ....*....|....*...
gi 53829365 154 -EAEFYNIASLVRLVKER 170
Cdd:cd18395  80 rEADFYQIQPLIEALQEK 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein KCTD11; KCTD11 may function as an antagonist of the Hedgehog pathway of cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in the undifferentiated state. It is a probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. It contains a BTB/POZ domain; in some cases the domain may be truncated. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. Variants of the human/mouse KCTD11 appear to contain truncated BTB/POZ domains.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829365  74 VRLNVGGTYFVTTRQTLGREPKSFLCRLC-CQEDPELDSDKDETGAYLIDRDPTYFGPILNYLRHGKLIITKELAEEGVL 152
Cdd:cd18370   1 VTLNVGGTLYSTTLETLTRFPDSMLGAMFrAGTPIPPNLNMQGGGHYFIDRDGKAFRHILNFLRLGRLDLPRGYGETALL 80

                ....*..
gi 53829365 153 E-EAEFY 158
Cdd:cd18370  81 RaEADFY 87

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 12 (KCTD12); KCTD12, also called predominantly fetal expressed T1 domain (Pfetin), is a BTB/POZ domain-containing protein that is an auxiliary subunit of GABAB receptors associated with mood disorders. It regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. It also regulates colorectal cancer cell stemness through the ERK pathway. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829365  74 VRLNVGGTYFVTTRQTLGREPKSFLCRLCCQEDPElDSDKDETGAYLIDRDPTYFGPILNYLRHGKLIITKELAEEGVLE 153
Cdd:cd18397   5 VELNVGGQVYVTRHTTLVSVPDSLLWHMFSQQKPG-ELARDSKGRFFLDRDGFLFRYILDYLRDLQLVLPDYFPERSRLQ 83

                        90
                ....*....|....*
gi 53829365 154 -EAEFYNIASLVRLV 167
Cdd:cd18397  84 rEAEFFQLPELVKRL 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in tumor necrosis factor, alpha-induced protein 1, endothelial (TNFAIP1); TNFAIP1, also called BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (BACURD2), or protein B12, is a BTB/POZ domain-containing protein that is involved in DNA replication, DNA damage repair and cell apoptosis, and is implicated in human diseases including cancer, Alzheimer's disease (AD) and type 2 diabetic nephropathy. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The BTB domains of other BACURD subfamily members, KCTD10 and KCTD13, form a novel two-fold symmetric tetramer that is distinct from the tetramer formed by voltage-gated potassium (Kv) channels.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829365  72 RWVRLNVGGTYFVTTRQTLGREPKsfLCRLCCQEDPELDSDKDetGAYLIDRDPTYFGPILNYLRHGKLIITKELAE-EG 150
Cdd:cd18401   3 KYVRLNVGGSLYYTTVQVLTRHDT--MLKAMFSGRMEVLTDKE--GWILIDRCGKHFGTILNYLRDDTVALPKSRQEiKE 78

                        90       100
                ....*....|....*....|....*.
gi 53829365 151 VLEEAEFYNIASLVRLVKERIRDNEN 176
Cdd:cd18401  79 LMAEAKYYLIQGLVDMCQAALQDKKD 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein KCTD8; KCTD8, a BTB/POZ domain-containing protein, is an auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. It interacts as a tetramer with GABRB1 and GABRB2. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829365  74 VRLNVGGTYFVTTRQTLGREPKSFLCRLCCQEDPElDSDKDETGAYLIDRDPTYFGPILNYLRHGKLIITKELAE-EGVL 152
Cdd:cd18396   6 VELNVGGQVYVTKHSTLLSVPDSTLASMFSRRAAR-ELPRDNRGRFFIDRDGFLFRYVLDYLRDKQLALPDHFPEkERLL 84

                        90
                ....*....|....*....
gi 53829365 153 EEAEFYNIASLVRLVKERI 171
Cdd:cd18396  85 REAEYFQLGDLVKLLTPKV 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 15 (KCTD15); KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains, closely related to KCTD15, form pentamers.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829365  74 VRLNVGGTYFVTTRQTLGREPKSFLCRLCCQEDP-ELDSDKDEtgaYLIDRDPTYFGPILNYLRHGKLIITKELAEEGVL 152
Cdd:cd18388   4 VHIDVGGHMYTSSLATLTKYPDSRISRLFNGTEPiVLDSLKQH---YFIDRDGEIFRYILSFLRTSKLLLPEDFKDFNLL 80

                        90
                ....*....|....
gi 53829365 153 -EEAEFYNIASLVR 165
Cdd:cd18388  81 yEEAKYYQLQPMVK 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 1 (KCNV1); KCNV1, also called neuronal potassium channel alpha subunit HNKA or voltage-gated potassium channel subunit Kv8.1, is a new neuronal voltage-gated potassium channel alpha subunit with specific inhibitory properties towards Shab and Shaw channels. It modulates KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2) channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. It can also down-regulate the channel activity of KCNB1, KCNB2, KCNC4 (also known as Kv3.4) and KCND1 (also known as Kv4.1), possibly by trapping them in intracellular membranes. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829365  76 LNVGGTYFVTTRQTLGREPKSFLCRLCCQEDP---ELDSDKD-ETGAYLIDRDPTYFGPILNYLRHGKLIITKELAEEGV 151
Cdd:cd18424   3 INVGGSRFVLSQQVLSSHPETRLGKLAVSVRDsvlELCDDANfVDNEYFFDRSSQAFKYIMNYYKTGHLHVMEELCAISF 82

                        90
                ....*....|..
gi 53829365 152 LEEAEFYNIASL 163
Cdd:cd18424  83 LQEIEYWGIDEL 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 2 (KCND2); KCND2, also called voltage-gated potassium channel subunit Kv4.2, is a major pore-forming subunit in somatodendritic subthreshold A-type potassium current I(SA) channels. It mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829365  74 VRLNVGGTYFVTTRQTLGREPKSFLCrlccqedpelDSDKD-----ETGAYLIDRDPTYFGPILNYLRHGKLIITKELAE 148
Cdd:cd18418   2 IVLNVSGTRFQTWRNTLERYPDTLLG----------SSERDffyheETQEYFFDRDPDIFRHILNFYRTGKLHYPRHECI 71

                        90
                ....*....|..
gi 53829365 149 EGVLEEAEFYNI 160
Cdd:cd18418  72 SAYDEELAFFGI 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel protein Shaw; Shaw, also called Shaw2, is a voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shaw is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829365  74 VRLNVGGTYFVTTRQTLGREPKSFLCRLC---CQEDPELDSdkdetgaYLIDRDPTYFGPILNYLRHGKLIITKELAEEG 150
Cdd:cd18416   4 VVLNVGGIRHETYKATLKKIPATRLSRLTealANYDPVLNE-------YFFDRHPGVFAQILNYYRTGKLHYPTDVCGPL 76

                        90
                ....*....|..
gi 53829365 151 VLEEAEFYNIAS 162
Cdd:cd18416  77 FEEELEFWGLDA 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 18 (KCTD18); KCTD18 is a BTB/POZ domain-containing protein with with unknown biological function. A duplication of the KCTD18 gene has been found in a patient with epilepsy, developmental delay, and autistic behavior, which may contribute to the phenotype. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829365  74 VRLNVGGTYFVTTRQTLGREPKSFLCRLCCQEDPeldSDKDETGAYLIDRDPTYFGPILNYLrHGKLIITK-ELAEEGVL 152
Cdd:cd18372   3 LRLNVGGCIYTARRESLCRFKDSMLSSMFSGRFP---LKLDESGACVIDRDGRLFKYLLDYL-HGELQIPEdEQTRLALQ 78

                ....*...
gi 53829365 153 EEAEFYNI 160
Cdd:cd18372  79 EEADYFGI 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 1 (KCTD1); KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829365  74 VRLNVGGTYFVTTRQTLGREPKSFLCRLCCQEDP-ELDSDKDEtgaYLIDRDPTYFGPILNYLRHGKLIITKELAEEGVL 152
Cdd:cd18387   5 VHIDVGGHMYTSSLATLTKYPESRIGRLFDGTEPiVLDSLKQH---YFIDRDGQMFRYILNFLRTSKLLIPDDFKDYSLL 81

                        90       100
                ....*....|....*....|....*
gi 53829365 153 -EEAEFYNIASLvRLVKERIRDNEN 176
Cdd:cd18387  82 yEEAKYFQLQPM-LLELERWKQDRE 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 1 (KCND1); KCND1, also called voltage-gated potassium channel subunit Kv4.1, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. It may contribute to I (To) current in heart and I (Sa) current in neurons. Its properties are modulated by interactions with other alpha subunits and with regulatory subunits. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829365  76 LNVGGTYFVTTRQTLGREPKSFLCrlccQEDPELDSDKDeTGAYLIDRDPTYFGPILNYLRHGKLIITKELAEEGVLEEA 155
Cdd:cd18417  39 VNVSGRRFQTWKNTLDRYPDTLLG----SSEKEFFYNED-TQEYFFDRDPEMFRHILNFYRTGRLHYPRHECIQAFDEEL 113

                ....*
gi 53829365 156 EFYNI 160
Cdd:cd18417 114 SFYGI 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 1 (KCNB1); KCNB1, also called delayed rectifier potassium channel 1 (DRK1) or voltage-gated potassium channel subunit Kv2.1, mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNB1 is involved in the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNB1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829365  71 ARWVRLNVGGTYFVTTRQTLGREPKSFLCRL--CCQEDPELDSDKD---ETGAYLIDRDPTYFGPILNYLRHGKLIITKE 145
Cdd:cd18411   9 SRRVKLNVGGLAHEVLWRTLDRLPRTRLGKLrdCNTHESLMEICDDynlEENEYFFDRHPGAFTSILNFYRTGKLHMMEE 88

                        90
                ....*....|....*
gi 53829365 146 LAEEGVLEEAEFYNI 160
Cdd:cd18411  89 MCALSFSQELDYWGI 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G member 3 (KCNG3); KCNG3, also called voltage-gated potassium channel subunit Kv6.3 or voltage-gated potassium channel subunit Kv10.1, is an electrically silent modulatory subunit that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG3 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829365  74 VRLNVGGTYFVTTRQTLGREPKSFLCRL--CCQEDP--ELDSDKD-ETGAYLIDRDPTYFGPILNYLRHGKLIITKELAe 148
Cdd:cd18422   1 VTLNVGGTRYSFSREVIKDFPLRRVSRLhgCLSEQDvlEVCDDYDrERNEYFFDRHSEAFGFIMLYVKYGKLRFVPQMC- 79

                        90
                ....*....|.
gi 53829365 149 egvleEAEFYN 159
Cdd:cd18422  80 -----ELSFYN 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shab and similar proteins; Shab is a slow delayed rectifier voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shab is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829365  71 ARWVRLNVGGTYFVTTRQTLGREPKSFLCRL--CCQEDPELDSDKDETGA---YLIDRDPTYFGPILNYLRHGKLIITKE 145
Cdd:cd18413   1 NRRVVINVGGVKHEVLWRTLDRMPHTRLGKLrdSNTHEAIVELCDDYSLAdneYFFDRHPRSFASILNFYRTGKLHLVEE 80

                        90
                ....*....|....*...
gi 53829365 146 LAEEGVLEEAEFYNIASL 163
Cdd:cd18413  81 MCVLAFSDDLEYWGVDEL 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4; KCNC2, also called Shaw-like potassium channel or voltage-gated potassium channel Kv3.2, is a delayed rectifier voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. It contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. KCNC4, also called KSHIIIC or voltage-gated potassium channel subunit Kv3.4, is a novel high-voltage-activating, tetraethylammonium (TEA)-sensitive, type-A potassium channel that mediates the voltage-dependent potassium ion permeability of excitable membranes. It plays a pivotal role in oxidative stress-related neural cell damage as an oxidation-sensitive channel. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC2 and KCNC4 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 53829365  74 VRLNVGGTYFVTTRQTLGREPKSFLCRLCCQEDPE--------LDSDKDETGA---YLIDRDPTYFGPILNYLRHGKL 140
Cdd:cd18415   4 IILNVGGTRHETYRSTLKTLPGTRLALLASSDPQGdcltqcsqVGGSDGSPGGgneFFFDRHPGVFAYVLNYYRTGKL 81

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNS/Kv9 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv9, also known as subfamily S, includes KCNS1 (Kv9.1), KCNS2 (Kv9.2) and KCNS3 (Kv9.3). They are regulatory alpha subunits that cannot form functional homo-tetrameric channels. Both KCNS1 and KCNS2 are delayed-rectifier K(+) channel alpha subunits that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. KCNS3 is a delayed-rectifier K(+) channel alpha subunit linked to tissue oxygenation responses. It can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829365  74 VRLNVGGTYFVTTRQTLGREPKSFLCRL--CCQEDP--ELDSDKDETG-AYLIDRDPTYFGPILNYLRHGKLIITKELAE 148
Cdd:cd18384   1 IRINVGGFRRRLSASALLRFPGTRLGRLlaCHSEEAilELCDDYDVAArEFYFDRNPGFFLYVLHFYRTGKLHVMDELCV 80

                        90
                ....*....|..
gi 53829365 149 EGVLEEAEFYNI 160
Cdd:cd18384  81 FSFSQEIEYWGI 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 1 (KCNS1); KCNS1, also called delayed-rectifier K(+) channel alpha subunit 1 or voltage-gated potassium channel subunit Kv9.1, is a modulatory alpha subunit of voltage-gated potassium channel that mediates neuropathic pain following nerve injury. It can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53829365  74 VRLNVGGTYFVTTRQTLGREPKSFLCRL--CCQEDPEL----DSDKDETGAYLiDRDPTYFGPILNYLRHGKLIITKELA 147
Cdd:cd18426   1 ININVGGLKRRLSSSTLSKFPDTRLGRLlsCDSEESILqicdDYDVSAKEFYF-DRNPGLFPYVLHFYQTGKLHIMEELC 79