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Conserved domains on  [gi|14149696|ref|NP_056305|]
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protein transport protein Sec31B [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-332 2.34e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 116.28  E-value: 2.34e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   13 AWSPASQYplyLATGtsaqqldssfSTNGTLEIFEVDFRDPSLDLK-HRGVLSALSRFHklvwgsfgsglleSSGVIVGG 91
Cdd:cd00200   16 AFSPDGKL---LATG----------SGDGTIKVWDLETGELLRTLKgHTGPVRDVAASA-------------DGTYLASG 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   92 GDNGMLILYNVthilsSGKEPVIAQKQkHTGAVRALDLNPfQGNLLASGASDSEIFIWDLNNLNVPMTLGSKSQqppeDI 171
Cdd:cd00200   70 SSDKTIRLWDL-----ETGECVRTLTG-HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD----WV 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696  172 KALSWNrQAQHILSSAHPSGKAVVWDLRKNEPIIKVSDHSNRMHCsgLAWHPDiATQLVLCSEDDrlpVIQLWDLRfASS 251
Cdd:cd00200  139 NSVAFS-PDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNS--VAFSPD-GEKLLSSSSDG---TIKLWDLS-TGK 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696  252 PLKVLESHSRGILSVSWSQaDAELLLTSAKDSQILCRNLGSSEVVYKLPTQSSWCFDVQWCPRDPSVFSaASFNGWISLY 331
Cdd:cd00200  211 CLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLAS-GSADGTIRIW 288


                 .
gi 14149696  332 S 332
Cdd:cd00200  289 D 289
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 728-1076 5.17e-12

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 70.57  E-value: 5.17e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696    728 LRGPHGVSPGPATTYRVTQYANLLAAQGSLATAMSFLPRDCAQPPVQQlrdrlfhaqgsavlgqQSPPFPFPRIVVGATL 807
Cdd:pfam03154  174 LQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQT----------------QSTAAPHTLIQQTPTL 237

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696    808 HSKETSSYRLGSQPSHQVPTPSPRPRVFTPQSSPAMPLAP------------SHPSPYQG-PRTQNISDYRAP-GPQAIQ 873
Cdd:pfam03154  238 HPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPmphslqtgpshmQHPVPPQPfPLTPQSSQSQVPpGPSPAA 317

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696    874 PLPLSPGVRPASSQPQLlggqrvQVPNPvgfPGTWPLPGSPLPMacPGIMRPGSTSLPETPRLFP---LLPLRPLGPGRM 950
Cdd:pfam03154  318 PGQSQQRIHTPPSQSQL------QSQQP---PREQPLPPAPLSM--PHIKPPPTTPIPQLPNPQShkhPPHLSGPSPFQM 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696    951 VSHTPAPPASFPVPYLPGD--PGA--------PCSSVLPTTG----ILTPHPGPQDSWKEAPAPRGNLQRNKLP----ET 1012
Cdd:pfam03154  387 NSNLPPPPALKPLSSLSTHhpPSAhppplqlmPQSQQLPPPPaqppVLTQSQSLPPPAASHPPTSGLHQVPSQSpfpqHP 466

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 14149696   1013 FMP--PAPITAPVMSLTPELQGILPSQPPVSSVSHAPPGVPGELS-----LQLQHLPPEKMERKELPPEHQ 1076
Cdd:pfam03154  467 FVPggPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVScplppVQIKEEALDEAEEPESPPPPP 537
ACE1-Sec16-like super family cl14807
Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; COPII coat ...
 561-691 5.24e-05

Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; COPII coat complex plays an important role in vesicular traffic of newly synthezised proteins from the endoplasmatic reticulum (ER) to the Golgi apparatus by mediating the formation of transport vesicles. COPII consists of an outer coat, made up of the scaffold proteins Sec31 and Sec13, and the cargo adaptor complex, Sec23 and Sec24, which are recruited by the small GTPase Sar1. Sec16 is involved in the early steps of the assembly process. Sec16 forms elongated heterotetramers with Sec13, Sec13-(Sec16)2-Sec13. It interacts with Sec13 by insertion of a single beta-blade to close the six-bladded beta propeller of Sec13. In the same way Sec13 interacts with Sec31 and Nup145C, a nuclear pore protein, all of these contain a structurally related ancestral coatomer element 1 (ACE1). Sec16 is believed to be a key component in maintaining the integrity of the ER exit site.


The actual alignment was detected with superfamily member cd09233:

Pssm-ID: 449359 [Multi-domain]  Cd Length: 314  Bit Score: 46.87  E-value: 5.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696  561 KDIDGLLSQA-------LLLGELGPAVELCLKEERFADAIILAQAGGTDLLKQTQERYlAKKKTKISSLLACVVQ---KN 630
Cdd:cd09233   56 VGTDIAEQKAlnrfrnlLLTGNRKEALELALDNGLWAHALLLASSLGKETWAEVVSRF-ARSESKLNDPLQTLYQlfsGN 134

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 14149696  631 WKDVVCTCS---------LKNWREALALLLTySGTEKFPELCDM-LGTRMEQEGsraLTSEARLCYVCSGS 691
Cdd:cd09233  135 SPEAITELAdnpaeaewaLGNWREHLAIILS-NRTSNLDLEALVeLGDLLAQRG---LVEAAHICYLLAGV 201
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-332 2.34e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.28  E-value: 2.34e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   13 AWSPASQYplyLATGtsaqqldssfSTNGTLEIFEVDFRDPSLDLK-HRGVLSALSRFHklvwgsfgsglleSSGVIVGG 91
Cdd:cd00200   16 AFSPDGKL---LATG----------SGDGTIKVWDLETGELLRTLKgHTGPVRDVAASA-------------DGTYLASG 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   92 GDNGMLILYNVthilsSGKEPVIAQKQkHTGAVRALDLNPfQGNLLASGASDSEIFIWDLNNLNVPMTLGSKSQqppeDI 171
Cdd:cd00200   70 SSDKTIRLWDL-----ETGECVRTLTG-HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD----WV 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696  172 KALSWNrQAQHILSSAHPSGKAVVWDLRKNEPIIKVSDHSNRMHCsgLAWHPDiATQLVLCSEDDrlpVIQLWDLRfASS 251
Cdd:cd00200  139 NSVAFS-PDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNS--VAFSPD-GEKLLSSSSDG---TIKLWDLS-TGK 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696  252 PLKVLESHSRGILSVSWSQaDAELLLTSAKDSQILCRNLGSSEVVYKLPTQSSWCFDVQWCPRDPSVFSaASFNGWISLY 331
Cdd:cd00200  211 CLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLAS-GSADGTIRIW 288


                 .
gi 14149696  332 S 332
Cdd:cd00200  289 D 289
WD40 COG2319
WD40 repeat [General function prediction only];
13-333 6.41e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.85  E-value: 6.41e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   13 AWSPASQYplyLATGtsaqqldssfSTNGTLEIFEVDFRDPSLDLK-HRGVLSALSrFHklvwgsfgsglleSSG-VIVG 90
Cdd:COG2319  127 AFSPDGKT---LASG----------SADGTVRLWDLATGKLLRTLTgHSGAVTSVA-FS-------------PDGkLLAS 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   91 GGDNGMLILYNVThilsSGKEpvIAQKQKHTGAVRALDLNPfQGNLLASGASDSEIFIWDLNNLNVPMTLGSKSQQpped 170
Cdd:COG2319  180 GSDDGTVRLWDLA----TGKL--LRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS---- 248

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696  171 IKALSWNRQAQHILsSAHPSGKAVVWDLRKNEPIIKVSDHSNRMHcsGLAWHPDiATQLVLCSEDDRlpvIQLWDLRfAS 250
Cdd:COG2319  249 VRSVAFSPDGRLLA-SGSADGTVRLWDLATGELLRTLTGHSGGVN--SVAFSPD-GKLLASGSDDGT---VRLWDLA-TG 320

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696  251 SPLKVLESHSRGILSVSWSqADAELLLTSAKDSQILCRNLGSSEVVYKLPTQSSWCFDVQWCPrDPSVFSAASFNGWISL 330
Cdd:COG2319  321 KLLRTLTGHTGAVRSVAFS-PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRL 398


                 ...
gi 14149696  331 YSV 333
Cdd:COG2319  399 WDL 401
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 728-1076 5.17e-12

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 70.57  E-value: 5.17e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696    728 LRGPHGVSPGPATTYRVTQYANLLAAQGSLATAMSFLPRDCAQPPVQQlrdrlfhaqgsavlgqQSPPFPFPRIVVGATL 807
Cdd:pfam03154  174 LQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQT----------------QSTAAPHTLIQQTPTL 237

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696    808 HSKETSSYRLGSQPSHQVPTPSPRPRVFTPQSSPAMPLAP------------SHPSPYQG-PRTQNISDYRAP-GPQAIQ 873
Cdd:pfam03154  238 HPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPmphslqtgpshmQHPVPPQPfPLTPQSSQSQVPpGPSPAA 317

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696    874 PLPLSPGVRPASSQPQLlggqrvQVPNPvgfPGTWPLPGSPLPMacPGIMRPGSTSLPETPRLFP---LLPLRPLGPGRM 950
Cdd:pfam03154  318 PGQSQQRIHTPPSQSQL------QSQQP---PREQPLPPAPLSM--PHIKPPPTTPIPQLPNPQShkhPPHLSGPSPFQM 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696    951 VSHTPAPPASFPVPYLPGD--PGA--------PCSSVLPTTG----ILTPHPGPQDSWKEAPAPRGNLQRNKLP----ET 1012
Cdd:pfam03154  387 NSNLPPPPALKPLSSLSTHhpPSAhppplqlmPQSQQLPPPPaqppVLTQSQSLPPPAASHPPTSGLHQVPSQSpfpqHP 466

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 14149696   1013 FMP--PAPITAPVMSLTPELQGILPSQPPVSSVSHAPPGVPGELS-----LQLQHLPPEKMERKELPPEHQ 1076
Cdd:pfam03154  467 FVPggPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVScplppVQIKEEALDEAEEPESPPPPP 537
PHA03247 PHA03247
large tegument protein UL36; Provisional
 771-1076 1.63e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 69.20  E-value: 1.63e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   771 PPVQQLRDRLFHAQGSAVLGQQSPPFPFPRIVVGATLHSKETSsyRLGSQPSHQVPTPSPRPRVFTPQSSPAMPLA---P 847
Cdd:PHA03247 2626 PPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRAR--RLGRAAQASSPPQRPRRRAARPTVGSLTSLAdppP 2703

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   848 SHPSPYQGPRTQNISDYRAPGPQAIQ----PLPLSPGVRPASSQPQLLGGqrvqvPNPVGFPGTWPLPGSPLPMACPGIM 923
Cdd:PHA03247 2704 PPPTPEPAPHALVSATPLPPGPAAARqaspALPAAPAPPAVPAGPATPGG-----PARPARPPTTAGPPAPAPPAAPAAG 2778

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   924 RPGSTSLPEtprlfpllplrplgpgrmVSHTPAPPASFPVPYLPGDPGA----PCSSVLPTTGILTPHPGPQDSWKEAPA 999
Cdd:PHA03247 2779 PPRRLTRPA------------------VASLSESRESLPSPWDPADPPAavlaPAAALPPAASPAGPLPPPTSAQPTAPP 2840

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 14149696  1000 -PRGNLQRNKLPETFMPP-APITAPVMSLTPELQGILPSQPPVSSVSHAPPGVPGElSLQLQHLPPEKMERKELPPEHQ 1076
Cdd:PHA03247 2841 pPPGPPPPSLPLGGSVAPgGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTE-SFALPPDQPERPPQPQAPPPPQ 2918
ACE1-Sec16-like cd09233
Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; COPII coat ...
 561-691 5.24e-05

Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; COPII coat complex plays an important role in vesicular traffic of newly synthezised proteins from the endoplasmatic reticulum (ER) to the Golgi apparatus by mediating the formation of transport vesicles. COPII consists of an outer coat, made up of the scaffold proteins Sec31 and Sec13, and the cargo adaptor complex, Sec23 and Sec24, which are recruited by the small GTPase Sar1. Sec16 is involved in the early steps of the assembly process. Sec16 forms elongated heterotetramers with Sec13, Sec13-(Sec16)2-Sec13. It interacts with Sec13 by insertion of a single beta-blade to close the six-bladded beta propeller of Sec13. In the same way Sec13 interacts with Sec31 and Nup145C, a nuclear pore protein, all of these contain a structurally related ancestral coatomer element 1 (ACE1). Sec16 is believed to be a key component in maintaining the integrity of the ER exit site.


Pssm-ID: 187750 [Multi-domain]  Cd Length: 314  Bit Score: 46.87  E-value: 5.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696  561 KDIDGLLSQA-------LLLGELGPAVELCLKEERFADAIILAQAGGTDLLKQTQERYlAKKKTKISSLLACVVQ---KN 630
Cdd:cd09233   56 VGTDIAEQKAlnrfrnlLLTGNRKEALELALDNGLWAHALLLASSLGKETWAEVVSRF-ARSESKLNDPLQTLYQlfsGN 134

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 14149696  631 WKDVVCTCS---------LKNWREALALLLTySGTEKFPELCDM-LGTRMEQEGsraLTSEARLCYVCSGS 691
Cdd:cd09233  135 SPEAITELAdnpaeaewaLGNWREHLAIILS-NRTSNLDLEALVeLGDLLAQRG---LVEAAHICYLLAGV 201
PTZ00420 PTZ00420
coronin; Provisional
 80-202 1.11e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.48  E-value: 1.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696    80 GLLESSGVIV------GGGDNGMLILYNVTHilssgKEPVIAQKqKHTGAVRALDLNPFQGNLLASGASDSEIFIWDL-- 151
Cdd:PTZ00420   33 GIACSSGFVAvpweveGGGLIGAIRLENQMR-----KPPVIKLK-GHTSSILDLQFNPCFSEILASGSEDLTIRVWEIph 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 14149696   152 NNLNV-----PMTL--GSKSQqppedIKALSWNRQAQHILSSAHPSGKAVVWDLrKNE 202
Cdd:PTZ00420  107 NDESVkeikdPQCIlkGHKKK-----ISIIDWNPMNYYIMCSSGFDSFVNIWDI-ENE 158
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 120-150 2.37e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 2.37e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 14149696     120 HTGAVRALDLNPfQGNLLASGASDSEIFIWD 150
Cdd:smart00320   11 HTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
120-150 1.00e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 1.00e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 14149696    120 HTGAVRALDLNPfQGNLLASGASDSEIFIWD 150
Cdd:pfam00400   10 HTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 865-990 1.12e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 42.87  E-value: 1.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696    865 RAPGPQAIQPLPLSPgvrpASSQPQLLG-GQRVQVP-NPVGFPGTWPLPGSplpmacpgiMRPGSTSLPETPRLFPLLPL 942
Cdd:TIGR01628  379 QPRMRQLPMGSPMGG----AMGQPPYYGqGPQQQFNgQPLGWPRMSMMPTP---------MGPGGPLRPNGLAPMNAVRA 445

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 14149696    943 RPLGPGRMvshtPAPPASFPVPYLPGDPGAPCSSVLPTTGILTPHPGP 990
Cdd:TIGR01628  446 PSRNAQNA----AQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASQGGQ 489
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 810-1038 1.18e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 42.83  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   810 KETSSYRLGSQPSHQ--VPTPSPRPRVFTPQSSPAMPLAPSHPSPY-QGPRTQNISDYRAPGPQA-IQPLPLSPGVRPAS 885
Cdd:NF033839  290 KKPSAPKPGMQPSPQpeKKEVKPEPETPKPEVKPQLEKPKPEVKPQpEKPKPEVKPQLETPKPEVkPQPEKPKPEVKPQP 369

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   886 SQPQllggqrvqvpnpvgfPGTWPLPGSPLPMACPGIMRPGSTSLPETPRLFPLLPLRPLGPGRMVSHTPAPPAsfpvPY 965
Cdd:NF033839  370 EKPK---------------PEVKPQPETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPK----PE 430

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 14149696   966 LPGDPGAPCSSVLPTTGILTPHPGPQdswKEAPAPRGNLQRNKlPETFMPPAPITAPVMSLTPELQGILPSQP 1038
Cdd:NF033839  431 VKPQPEKPKPEVKPQPEKPKPEVKPQ---PETPKPEVKPQPEK-PKPEVKPQPEKPKPDNSKPQADDKKPSTP 499
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 736-1074 8.58e-03

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 40.05  E-value: 8.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696  736 PGPATTYRVTQYANLLAAQGS--------LATAMSFLPRDCAQPPVQQLRDRLFHAQGSavLGQQSPPFPFPRIVVGATL 807
Cdd:COG5180  133 PKAKVTREATSASAGVALAAAllqrsdpiLAKDPDGDSASTLPPPAEKLDKVLTEPRDA--LKDSPEKLDRPKVEVKDEA 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696  808 HSKETSSYRLGSQPSHQVPTPSPRPRVFTPQSSPAMPLAPSHPSPyqGPRTQNISDYRAPGPQAIQPLPLSPGVRPASSQ 887
Cdd:COG5180  211 QEEPPDLTGGADHPRPEAASSPKVDPPSTSEARSRPATVDAQPEM--RPPADAKERRRAAIGDTPAAEPPGLPVLEAGSE 288

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696  888 PQLlGGQRVQVPNPVGFPGTWPLPGSPLPMACPGIMRPGSTSLPEtprLFPLLPLRPLGPGRMVSHTPA--PPASFPVPY 965
Cdd:COG5180  289 PQS-DAPEAETARPIDVKGVASAPPATRPVRPPGGARDPGTPRPG---QPTERPAGVPEAASDAGQPPSayPPAEEAVPG 364

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696  966 LPGDPGAP--CSSVLPTTGILTPHPGPQDSWKEAPAPRGNLQRNKLPEtFMPPAPITAPVMSLTPELQGILPSQPPVSSV 1043
Cdd:COG5180  365 KPLEQGAPrpGSSGGDGAPFQPPNGAPQPGLGRRGAPGPPMGAGDLVQ-AALDGGGRETASLGGAAGGAGQGPKADFVPG 443

                        330       340       350
                 ....*....|....*....|....*....|.
gi 14149696 1044 SHAPPGVPGELSLQLQHLPPEKMERKELPPE 1074
Cdd:COG5180  444 DAESVSGPAGLADQAGAAASTAMADFVAPVT 474
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-332 2.34e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.28  E-value: 2.34e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   13 AWSPASQYplyLATGtsaqqldssfSTNGTLEIFEVDFRDPSLDLK-HRGVLSALSRFHklvwgsfgsglleSSGVIVGG 91
Cdd:cd00200   16 AFSPDGKL---LATG----------SGDGTIKVWDLETGELLRTLKgHTGPVRDVAASA-------------DGTYLASG 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   92 GDNGMLILYNVthilsSGKEPVIAQKQkHTGAVRALDLNPfQGNLLASGASDSEIFIWDLNNLNVPMTLGSKSQqppeDI 171
Cdd:cd00200   70 SSDKTIRLWDL-----ETGECVRTLTG-HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD----WV 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696  172 KALSWNrQAQHILSSAHPSGKAVVWDLRKNEPIIKVSDHSNRMHCsgLAWHPDiATQLVLCSEDDrlpVIQLWDLRfASS 251
Cdd:cd00200  139 NSVAFS-PDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNS--VAFSPD-GEKLLSSSSDG---TIKLWDLS-TGK 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696  252 PLKVLESHSRGILSVSWSQaDAELLLTSAKDSQILCRNLGSSEVVYKLPTQSSWCFDVQWCPRDPSVFSaASFNGWISLY 331
Cdd:cd00200  211 CLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLAS-GSADGTIRIW 288


                 .
gi 14149696  332 S 332
Cdd:cd00200  289 D 289
WD40 COG2319
WD40 repeat [General function prediction only];
13-333 6.41e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.85  E-value: 6.41e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   13 AWSPASQYplyLATGtsaqqldssfSTNGTLEIFEVDFRDPSLDLK-HRGVLSALSrFHklvwgsfgsglleSSG-VIVG 90
Cdd:COG2319  127 AFSPDGKT---LASG----------SADGTVRLWDLATGKLLRTLTgHSGAVTSVA-FS-------------PDGkLLAS 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   91 GGDNGMLILYNVThilsSGKEpvIAQKQKHTGAVRALDLNPfQGNLLASGASDSEIFIWDLNNLNVPMTLGSKSQQpped 170
Cdd:COG2319  180 GSDDGTVRLWDLA----TGKL--LRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS---- 248

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696  171 IKALSWNRQAQHILsSAHPSGKAVVWDLRKNEPIIKVSDHSNRMHcsGLAWHPDiATQLVLCSEDDRlpvIQLWDLRfAS 250
Cdd:COG2319  249 VRSVAFSPDGRLLA-SGSADGTVRLWDLATGELLRTLTGHSGGVN--SVAFSPD-GKLLASGSDDGT---VRLWDLA-TG 320

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696  251 SPLKVLESHSRGILSVSWSqADAELLLTSAKDSQILCRNLGSSEVVYKLPTQSSWCFDVQWCPrDPSVFSAASFNGWISL 330
Cdd:COG2319  321 KLLRTLTGHTGAVRSVAFS-PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRL 398


                 ...
gi 14149696  331 YSV 333
Cdd:COG2319  399 WDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 120-334 1.86e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 104.72  E-value: 1.86e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696  120 HTGAVRALDLNPfQGNLLASGASDSEIFIWDLNNLNVPMTLGSKSqQPPEDIKALSWNRQ-------------------- 179
Cdd:cd00200    8 HTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHT-GPVRDVAASADGTYlasgssdktirlwdletgec 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696  180 ------------------AQHILSSAHPSGKAVVWDLRKNEPIIKVSDHSNRMHCsgLAWHPDiaTQLVLCSEDDRLpvI 241
Cdd:cd00200   86 vrtltghtsyvssvafspDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNS--VAFSPD--GTFVASSSQDGT--I 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696  242 QLWDLRfASSPLKVLESHSRGILSVSWSqADAELLLTSAKDSQILCRNLGSSEVVYKLPTQSSWCFDVQWCPrDPSVFSA 321
Cdd:cd00200  160 KLWDLR-TGKCVATLTGHTGEVNSVAFS-PDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLAS 236

                        250
                 ....*....|...
gi 14149696  322 ASFNGWISLYSVM 334
Cdd:cd00200  237 GSEDGTIRVWDLR 249
WD40 COG2319
WD40 repeat [General function prediction only];
51-333 5.06e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.74  E-value: 5.06e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   51 RDPSLDLKHRGVLSALSRFHKLVWGSFGSGLLESSGVIVGGGDNGMLILYNVTHILSSGKEPVIAQKQKHTGAVRALDLN 130
Cdd:COG2319    8 ALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696  131 PfQGNLLASGASDSEIFIWDLNNLNVPMTLgsksQQPPEDIKALSWNRQAQHILSSAHPsGKAVVWDLRKNEPIIKVSDH 210
Cdd:COG2319   88 P-DGRLLASASADGTVRLWDLATGLLLRTL----TGHTGAVRSVAFSPDGKTLASGSAD-GTVRLWDLATGKLLRTLTGH 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696  211 SNRMHCsgLAWHPDiATQLVLCSEDDRlpvIQLWDLRfASSPLKVLESHSRGILSVSWSqADAELLLTSAKDSQILCRNL 290
Cdd:COG2319  162 SGAVTS--VAFSPD-GKLLASGSDDGT---VRLWDLA-TGKLLRTLTGHTGAVRSVAFS-PDGKLLASGSADGTVRLWDL 233

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 14149696  291 GSSEVVYKLPTQSSWCFDVQWCPrDPSVFSAASFNGWISLYSV 333
Cdd:COG2319  234 ATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDL 275
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 728-1076 5.17e-12

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 70.57  E-value: 5.17e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696    728 LRGPHGVSPGPATTYRVTQYANLLAAQGSLATAMSFLPRDCAQPPVQQlrdrlfhaqgsavlgqQSPPFPFPRIVVGATL 807
Cdd:pfam03154  174 LQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQT----------------QSTAAPHTLIQQTPTL 237

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696    808 HSKETSSYRLGSQPSHQVPTPSPRPRVFTPQSSPAMPLAP------------SHPSPYQG-PRTQNISDYRAP-GPQAIQ 873
Cdd:pfam03154  238 HPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPmphslqtgpshmQHPVPPQPfPLTPQSSQSQVPpGPSPAA 317

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696    874 PLPLSPGVRPASSQPQLlggqrvQVPNPvgfPGTWPLPGSPLPMacPGIMRPGSTSLPETPRLFP---LLPLRPLGPGRM 950
Cdd:pfam03154  318 PGQSQQRIHTPPSQSQL------QSQQP---PREQPLPPAPLSM--PHIKPPPTTPIPQLPNPQShkhPPHLSGPSPFQM 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696    951 VSHTPAPPASFPVPYLPGD--PGA--------PCSSVLPTTG----ILTPHPGPQDSWKEAPAPRGNLQRNKLP----ET 1012
Cdd:pfam03154  387 NSNLPPPPALKPLSSLSTHhpPSAhppplqlmPQSQQLPPPPaqppVLTQSQSLPPPAASHPPTSGLHQVPSQSpfpqHP 466

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 14149696   1013 FMP--PAPITAPVMSLTPELQGILPSQPPVSSVSHAPPGVPGELS-----LQLQHLPPEKMERKELPPEHQ 1076
Cdd:pfam03154  467 FVPggPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVScplppVQIKEEALDEAEEPESPPPPP 537
PHA03247 PHA03247
large tegument protein UL36; Provisional
 771-1076 1.63e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 69.20  E-value: 1.63e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   771 PPVQQLRDRLFHAQGSAVLGQQSPPFPFPRIVVGATLHSKETSsyRLGSQPSHQVPTPSPRPRVFTPQSSPAMPLA---P 847
Cdd:PHA03247 2626 PPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRAR--RLGRAAQASSPPQRPRRRAARPTVGSLTSLAdppP 2703

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   848 SHPSPYQGPRTQNISDYRAPGPQAIQ----PLPLSPGVRPASSQPQLLGGqrvqvPNPVGFPGTWPLPGSPLPMACPGIM 923
Cdd:PHA03247 2704 PPPTPEPAPHALVSATPLPPGPAAARqaspALPAAPAPPAVPAGPATPGG-----PARPARPPTTAGPPAPAPPAAPAAG 2778

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   924 RPGSTSLPEtprlfpllplrplgpgrmVSHTPAPPASFPVPYLPGDPGA----PCSSVLPTTGILTPHPGPQDSWKEAPA 999
Cdd:PHA03247 2779 PPRRLTRPA------------------VASLSESRESLPSPWDPADPPAavlaPAAALPPAASPAGPLPPPTSAQPTAPP 2840

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 14149696  1000 -PRGNLQRNKLPETFMPP-APITAPVMSLTPELQGILPSQPPVSSVSHAPPGVPGElSLQLQHLPPEKMERKELPPEHQ 1076
Cdd:PHA03247 2841 pPPGPPPPSLPLGGSVAPgGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTE-SFALPPDQPERPPQPQAPPPPQ 2918
PHA03247 PHA03247
large tegument protein UL36; Provisional
 794-1078 4.27e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.04  E-value: 4.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   794 PPFPFPRIvvgatlHSKETSSYRLGSQPSHQVPTPSPRP-RVFTPQSSPAMPLAPSHPSPYQGPRTQ-------NISDYR 865
Cdd:PHA03247 2626 PPPPSPSP------AANEPDPHPPPTVPPPERPRDDPAPgRVSRPRRARRLGRAAQASSPPQRPRRRaarptvgSLTSLA 2699

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   866 APGPQAIQPLPLSPGVRPASSQPQLLGGQRVQVPNPVGFPGTWPLPGSP-LPMACPGIMRPGSTSLPEtprlfpllplrp 944
Cdd:PHA03247 2700 DPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPaTPGGPARPARPPTTAGPP------------ 2767

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   945 lgpgrmvshTPAPPASFPVPYLPGDPGAPCSSVLPTTGILTPHPGPQDSWKEAPAPRGNLQRNKLPETFMPPAPITAPVM 1024
Cdd:PHA03247 2768 ---------APAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTA 2838

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 14149696  1025 SLTPElQGILPSQPPVSSVS-------HAPPGVPGELSLQLQHLPPEKMERKELPPEHQSL 1078
Cdd:PHA03247 2839 PPPPP-GPPPPSLPLGGSVApggdvrrRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESF 2898
PHA03247 PHA03247
large tegument protein UL36; Provisional
 821-1052 1.90e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 65.73  E-value: 1.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   821 PSHQVPTP--SPRP-------RVFTP-----QSSPAMPLAPSHPSPYQGPRTQNISDYRAPGPQAIQPLPLS---PGVRP 883
Cdd:PHA03247 2564 PDRSVPPPrpAPRPsepavtsRARRPdappqSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAAnepDPHPP 2643

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   884 ASSQPQLL-----GGQRVQVPNPVGFPGTWPLPGSPLPMACPGIMRPGSTSLPETPRLFPLLPLRPLGPGRMVSHTPAPP 958
Cdd:PHA03247 2644 PTVPPPERprddpAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPP 2723

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   959 -------ASFPVPYLPGDPGAPCSSVLP-----------TTGILTPHP------GPQDSWKEAPAPRGNLQRNKLPETFM 1014
Cdd:PHA03247 2724 gpaaarqASPALPAAPAPPAVPAGPATPggparparpptTAGPPAPAPpaapaaGPPRRLTRPAVASLSESRESLPSPWD 2803

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 14149696  1015 P---PAPITAPVMSLTPELQGILPSQPPVSSVSHAPPGVPG 1052
Cdd:PHA03247 2804 PadpPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG 2844
PHA03247 PHA03247
large tegument protein UL36; Provisional
 729-1081 4.16e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 64.57  E-value: 4.16e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   729 RGPHGVSPGPATTYRV-------TQYANLLAAQGSLATAMSFLPRDCAQPPVQQLRDRLfHAQGSAVLGQQSPPFPFPRI 801
Cdd:PHA03247 2609 RGPAPPSPLPPDTHAPdppppspSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRA-RRLGRAAQASSPPQRPRRRA 2687

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   802 VVGATlhSKETSSYRlgsqPSHQVPTPSPRPRVFTP------------QSSPAMPLAPSHPSPYQGPRTqNISDYRAPGP 869
Cdd:PHA03247 2688 ARPTV--GSLTSLAD----PPPPPPTPEPAPHALVSatplppgpaaarQASPALPAAPAPPAVPAGPAT-PGGPARPARP 2760

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   870 QAIQ--PLPLSPGVRPASSQPQL--------------LGGQRVQVPNPVGFPG-------------TWPLPGSPLPMACP 920
Cdd:PHA03247 2761 PTTAgpPAPAPPAAPAAGPPRRLtrpavaslsesresLPSPWDPADPPAAVLApaaalppaaspagPLPPPTSAQPTAPP 2840

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   921 GIMRPGSTSLPETPRLFPLLPLRPLGPGRMVSHTPAPPASFPVPYLPGDPGAPCSSVLPttgilTPHPGPQdswkeaPAP 1000
Cdd:PHA03247 2841 PPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFA-----LPPDQPE------RPP 2909

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696  1001 RGNLQRNKLPETFMPPAPITAPVMSLTPELQGILPSQPPVSSVSHAPPGVPGElslQLQHLPPEKME--RKELPPEHQSL 1078
Cdd:PHA03247 2910 QPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQP---WLGALVPGRVAvpRFRVPQPAPSR 2986


                  ...
gi 14149696  1079 KSS 1081
Cdd:PHA03247 2987 EAP 2989
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 793-1063 2.14e-08

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 58.63  E-value: 2.14e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696    793 SPPFPFPRIVVGATLHSKETSSYRlGSQPSHQVPT--------------------PSPRPRVFTPQSSPAMPLAPSHPSP 852
Cdd:pfam03154  145 SPSIPSPQDNESDSDSSAQQQILQ-TQPPVLQAQSgaasppsppppgttqaatagPTPSAPSVPPQGSPATSQPPNQTQS 223

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696    853 YQGP-----RTQNISDYRAPGPQ-AIQPLPLSP---GVRPASSQPQLLGGQRVQVPNPVGF-PGTWPLPGSPLPMACPGI 922
Cdd:pfam03154  224 TAAPhtliqQTPTLHPQRLPSPHpPLQPMTQPPppsQVSPQPLPQPSLHGQMPPMPHSLQTgPSHMQHPVPPQPFPLTPQ 303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696    923 MRPGSTSLPETPRLFPLLPLRplgpgrmvSHTPAPPASFPvpylPGDPgaPCSSVLPTTGILTPH--PGPQDSWKEAPAP 1000
Cdd:pfam03154  304 SSQSQVPPGPSPAAPGQSQQR--------IHTPPSQSQLQ----SQQP--PREQPLPPAPLSMPHikPPPTTPIPQLPNP 369

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 14149696   1001 rgnlQRNKLPETFMPPAPITAPVmSLTPElqgilPSQPPVSSVS-HAPPGV---PGELSLQLQHLPP 1063
Cdd:pfam03154  370 ----QSHKHPPHLSGPSPFQMNS-NLPPP-----PALKPLSSLStHHPPSAhppPLQLMPQSQQLPP 426
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
817-1053 1.49e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 52.57  E-value: 1.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   817 LGSQPSHQ-----VPTPSPRPRVFTPQSSPAMPLAPSHPSPYQGPRTQNISDYRAPGPQAIQPLPLSPGVRPASSQPQLL 891
Cdd:PRK12323  361 LAFRPGQSgggagPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQAS 440

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   892 GGQRVQVPNPVGFPGTWPLPGSPLPMACPGIMRPGSTSLPETPRLFPLLPlrplgpgrmvshtPAPPASFPVPYLPGDPG 971
Cdd:PRK12323  441 ARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPA-------------PADDDPPPWEELPPEFA 507

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   972 APcssvlpttGILTPHPGPQDsWKEAPAPRGNLQRNKLPETFMPPAPITAPVMSLTPELQGILPSQPPVSSVSHAPPGVP 1051
Cdd:PRK12323  508 SP--------APAQPDAAPAG-WVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFD 578


                  ..
gi 14149696  1052 GE 1053
Cdd:PRK12323  579 GD 580
PHA03247 PHA03247
large tegument protein UL36; Provisional
 791-1095 2.64e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.25  E-value: 2.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   791 QQSPPFPFPRIVVGATLHSKETSSYRLGSQPSHQVPTPSPRP----------RVFTPQS-----SPAMPLAPSHPSPYQG 855
Cdd:PHA03247 2704 PPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPagpatpggpaRPARPPTtagppAPAPPAAPAAGPPRRL 2783

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   856 PR----TQNISDYRAPGPQAIQPLP---------LSPGVRPASSQPQLLGGQRVQVPNPVGFP------GTWPLPGSPLP 916
Cdd:PHA03247 2784 TRpavaSLSESRESLPSPWDPADPPaavlapaaaLPPAASPAGPLPPPTSAQPTAPPPPPGPPppslplGGSVAPGGDVR 2863

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   917 MACPGIMRPGSTSLPETPRLFPLLPLRPLGPGRMVSHTPAPPASFPVPYLPGDPGAPcsSVLPTTGILTPHPGPQDSWKE 996
Cdd:PHA03247 2864 RRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQ--PQPPPPPQPQPPPPPPPRPQP 2941

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   997 APAPRGNLQRNKLPETFMP--------PAPITAPVMSLTPELQGI-LPSQPPVSSVSHAPPGV---PGELSLQLQHLPPE 1064
Cdd:PHA03247 2942 PLAPTTDPAGAGEPSGAVPqpwlgalvPGRVAVPRFRVPQPAPSReAPASSTPPLTGHSLSRVsswASSLALHEETDPPP 3021

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 14149696  1065 KMERKELPP----EHQSLKSSFEALLQRCSLSATD 1095
Cdd:PHA03247 3022 VSLKQTLWPpddtEDSDADSLFDSDSERSDLEALD 3056
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 792-1048 1.82e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 49.31  E-value: 1.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   792 QSPPFPFPRIVVgatlhSKETSSYRLGSQPSHQVPTPSPRPRVFTPQSSPAMPLAPsHPSPYQGPRTQNISDYRAPGPQA 871
Cdd:PRK10263  342 QTPPVASVDVPP-----AQPTVAWQPVPGPQTGEPVIAPAPEGYPQQSQYAQPAVQ-YNEPLQQPVQPQQPYYAPAAEQP 415

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   872 IQPLPLSPGVRPASSQPQLLGgqrvQVPNPVGFPGTWPLPGSPLpmacpgiMRPGSTSLPETPRLFpllplrplgpgrmv 951
Cdd:PRK10263  416 AQQPYYAPAPEQPAQQPYYAP----APEQPVAGNAWQAEEQQST-------FAPQSTYQTEQTYQQ-------------- 470

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   952 shtpapPASFPVPYLPGDPGAPCSSVLPTTGILTPHPG--PQDSWKEAPAPRGNlQRNKLPETFMP-PAPITAPVMSLTP 1028
Cdd:PRK10263  471 ------PAAQEPLYQQPQPVEQQPVVEPEPVVEETKPArpPLYYFEEVEEKRAR-EREQLAAWYQPiPEPVKEPEPIKSS 543

                         250       260
                  ....*....|....*....|
gi 14149696  1029 ELQGILPSQPPVSSVSHAPP 1048
Cdd:PRK10263  544 LKAPSVAAVPPVEAAAAVSP 563
ACE1-Sec16-like cd09233
Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; COPII coat ...
 561-691 5.24e-05

Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; COPII coat complex plays an important role in vesicular traffic of newly synthezised proteins from the endoplasmatic reticulum (ER) to the Golgi apparatus by mediating the formation of transport vesicles. COPII consists of an outer coat, made up of the scaffold proteins Sec31 and Sec13, and the cargo adaptor complex, Sec23 and Sec24, which are recruited by the small GTPase Sar1. Sec16 is involved in the early steps of the assembly process. Sec16 forms elongated heterotetramers with Sec13, Sec13-(Sec16)2-Sec13. It interacts with Sec13 by insertion of a single beta-blade to close the six-bladded beta propeller of Sec13. In the same way Sec13 interacts with Sec31 and Nup145C, a nuclear pore protein, all of these contain a structurally related ancestral coatomer element 1 (ACE1). Sec16 is believed to be a key component in maintaining the integrity of the ER exit site.


Pssm-ID: 187750 [Multi-domain]  Cd Length: 314  Bit Score: 46.87  E-value: 5.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696  561 KDIDGLLSQA-------LLLGELGPAVELCLKEERFADAIILAQAGGTDLLKQTQERYlAKKKTKISSLLACVVQ---KN 630
Cdd:cd09233   56 VGTDIAEQKAlnrfrnlLLTGNRKEALELALDNGLWAHALLLASSLGKETWAEVVSRF-ARSESKLNDPLQTLYQlfsGN 134

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 14149696  631 WKDVVCTCS---------LKNWREALALLLTySGTEKFPELCDM-LGTRMEQEGsraLTSEARLCYVCSGS 691
Cdd:cd09233  135 SPEAITELAdnpaeaewaLGNWREHLAIILS-NRTSNLDLEALVeLGDLLAQRG---LVEAAHICYLLAGV 201
PHA03378 PHA03378
EBNA-3B; Provisional
 808-1076 5.73e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 47.37  E-value: 5.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   808 HSKETSSYRLGSQPSHQVPTPSPR-------PRVF-TPQSSPAMPLAPSHPS-------PYQgPRTQNISDYRAP--GPQ 870
Cdd:PHA03378  614 HIPETSAPRQWPMPLRPIPMRPLRmqpitfnVLVFpTPHQPPQVEITPYKPTwtqighiPYQ-PSPTGANTMLPIqwAPG 692

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   871 AIQPLPLSPG-VRPASSQPqllggqrVQVPNPVGFPGTWPLPGSPLPMACPGIMRPGSTSLPETPRLFPLLPLRPLGPGR 949
Cdd:PHA03378  693 TMQPPPRAPTpMRPPAAPP-------GRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRAR 765

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   950 MVSHTPAPPASFPVPYLPGDP-----GAPCSS----VLPTTGILTPH--PGPQDSWKEA-------------PAPRGNLQ 1005
Cdd:PHA03378  766 PPAAAPGAPTPQPPPQAPPAPqqrprGAPTPQpppqAGPTSMQLMPRaaPGQQGPTKQIlrqlltggvkrgrPSLKKPAA 845

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696  1006 RNKLPETFMPPAP--------ITAPVM---SLTP-ELQGILPSQPPV--SSVSHAPPGVPGE----LSLQLQHLPPEKME 1067
Cdd:PHA03378  846 LERQAAAGPTPSPgsgtsdkiVQAPVFyppVLQPiQVMRQLGSVRAAaaSTVTQAPTEYTGErrgvGPMHPTDIPPSKRA 925


                  ....*....
gi 14149696  1068 RKELPPEHQ 1076
Cdd:PHA03378  926 KTDAYVESQ 934
WD40 COG2319
WD40 repeat [General function prediction only];
13-153 6.10e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.83  E-value: 6.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   13 AWSPASQYplyLATGtsaqqldssfSTNGTLEIFevdfrdpslDLKHRGVLSALSRFHKLVWG-SFGSglleSSGVIVGG 91
Cdd:COG2319  295 AFSPDGKL---LASG----------SDDGTVRLW---------DLATGKLLRTLTGHTGAVRSvAFSP----DGKTLASG 348

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 14149696   92 GDNGMLILYNvthiLSSGKEpvIAQKQKHTGAVRALDLNPfQGNLLASGASDSEIFIWDLNN 153
Cdd:COG2319  349 SDDGTVRLWD----LATGEL--LRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLAT 403
PTZ00420 PTZ00420
coronin; Provisional
 80-202 1.11e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.48  E-value: 1.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696    80 GLLESSGVIV------GGGDNGMLILYNVTHilssgKEPVIAQKqKHTGAVRALDLNPFQGNLLASGASDSEIFIWDL-- 151
Cdd:PTZ00420   33 GIACSSGFVAvpweveGGGLIGAIRLENQMR-----KPPVIKLK-GHTSSILDLQFNPCFSEILASGSEDLTIRVWEIph 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 14149696   152 NNLNV-----PMTL--GSKSQqppedIKALSWNRQAQHILSSAHPSGKAVVWDLrKNE 202
Cdd:PTZ00420  107 NDESVkeikdPQCIlkGHKKK-----ISIIDWNPMNYYIMCSSGFDSFVNIWDI-ENE 158
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 120-150 2.37e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 2.37e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 14149696     120 HTGAVRALDLNPfQGNLLASGASDSEIFIWD 150
Cdd:smart00320   11 HTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 114-312 6.01e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 43.73  E-value: 6.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   114 IAQKQKHTGAVRALDLNPFQGNLLASGASDSEIFIWDLNNLNVPMTLGSKSQQppedIKALSWNRQAQhILSSAHPSGKA 193
Cdd:PTZ00421  118 IVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQ----ITSLEWNLDGS-LLCTTSKDKKL 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   194 VVWDLRKNEPIIKVSDH-SNRMHCSGLAWHPDIATQLVLCSEDDRLpvIQLWDLRFASSPLKVLESHSRGILSVSWSQAD 272
Cdd:PTZ00421  193 NIIDPRDGTIVSSVEAHaSAKSQRCLWAKRKDLIITLGCSKSQQRQ--IMLWDTRKMASPYSTVDLDQSSALFIPFFDED 270

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 14149696   273 AELLLTSAKDSQIL------------CRNLGSSEVVYKLPTQSSWCFDVQWC 312
Cdd:PTZ00421  271 TNLLYIGSKGEGNIrcfelmnerltfCSSYSSVEPHKGLCMMPKWSLDTRKC 322
PHA03377 PHA03377
EBNA-3C; Provisional
 765-1051 9.65e-04

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 43.50  E-value: 9.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   765 PRDCAQPPVQQ-LRDRLFHAQgsavLGQQSPPFPFPRIVVGATLHSKETSSYRlgsQPSHQVPTPSPR--PRVFTPQSSP 841
Cdd:PHA03377  622 PRDMAPSVVRMfLRERLLEQS----TGPKPKSFWEMRAGRDGSGIQQEPSSRR---QPATQSTPPRPSwlPSVFVLPSVD 694

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   842 A---MPLAPSHPSPYQGprTQNISDYRAP---GPQAIQPLPLSPGVRPASSQPQLLGG----QRVQVPnpvgFPGTWPLP 911
Cdd:PHA03377  695 AgraQPSEESHLSSMSP--TQPISHEEQPryeDPDDPLDLSLHPDQAPPPSHQAPYSGheepQAQQAP----YPGYWEPR 768

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   912 GSPLPMAcpGIMRPGSTSLPETPRLFPLLPLRPLGPGRMVSHTPAPPASFPVPYLPGDPGAPCSsvlpttgiltPHPGPQ 991
Cdd:PHA03377  769 PPQAPYL--GYQEPQAQGVQVSSYPGYAGPWGLRAQHPRYRHSWAYWSQYPGHGHPQGPWAPRP----------PHLPPQ 836

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 14149696   992 dsWKEAPAPrGNLQRNKLPETFMPPAPITaPVMSLTPELQGILP----SQPPVSSVSHAPPGVP 1051
Cdd:PHA03377  837 --WDGSAGH-GQDQVSQFPHLQSETGPPR-LQLSQVPQLPYSQTlvssSAPSWSSPQPRAPIRP 896
WD40 pfam00400
WD domain, G-beta repeat;
120-150 1.00e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 1.00e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 14149696    120 HTGAVRALDLNPfQGNLLASGASDSEIFIWD 150
Cdd:pfam00400   10 HTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 865-990 1.12e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 42.87  E-value: 1.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696    865 RAPGPQAIQPLPLSPgvrpASSQPQLLG-GQRVQVP-NPVGFPGTWPLPGSplpmacpgiMRPGSTSLPETPRLFPLLPL 942
Cdd:TIGR01628  379 QPRMRQLPMGSPMGG----AMGQPPYYGqGPQQQFNgQPLGWPRMSMMPTP---------MGPGGPLRPNGLAPMNAVRA 445

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 14149696    943 RPLGPGRMvshtPAPPASFPVPYLPGDPGAPCSSVLPTTGILTPHPGP 990
Cdd:TIGR01628  446 PSRNAQNA----AQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASQGGQ 489
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 810-1038 1.18e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 42.83  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   810 KETSSYRLGSQPSHQ--VPTPSPRPRVFTPQSSPAMPLAPSHPSPY-QGPRTQNISDYRAPGPQA-IQPLPLSPGVRPAS 885
Cdd:NF033839  290 KKPSAPKPGMQPSPQpeKKEVKPEPETPKPEVKPQLEKPKPEVKPQpEKPKPEVKPQLETPKPEVkPQPEKPKPEVKPQP 369

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   886 SQPQllggqrvqvpnpvgfPGTWPLPGSPLPMACPGIMRPGSTSLPETPRLFPLLPLRPLGPGRMVSHTPAPPAsfpvPY 965
Cdd:NF033839  370 EKPK---------------PEVKPQPETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPK----PE 430

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 14149696   966 LPGDPGAPCSSVLPTTGILTPHPGPQdswKEAPAPRGNLQRNKlPETFMPPAPITAPVMSLTPELQGILPSQP 1038
Cdd:NF033839  431 VKPQPEKPKPEVKPQPEKPKPEVKPQ---PETPKPEVKPQPEK-PKPEVKPQPEKPKPDNSKPQADDKKPSTP 499
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 792-1011 1.57e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.83  E-value: 1.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696    792 QSPPFPFPRIVVGA--TLHSKETSSYRLGSQPSHQVP---TPSPRPRVFTPQSSPAMPLA-------PSH---PSPYQGP 856
Cdd:pfam03154  308 QVPPGPSPAAPGQSqqRIHTPPSQSQLQSQQPPREQPlppAPLSMPHIKPPPTTPIPQLPnpqshkhPPHlsgPSPFQMN 387

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696    857 RT----------QNISDYRAPG---------PQAiQPLPLSPGVRPASSQPQLLGGQRVQVPNPVGF---PGTWPLPGSP 914
Cdd:pfam03154  388 SNlppppalkplSSLSTHHPPSahppplqlmPQS-QQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLhqvPSQSPFPQHP 466

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696    915 LPMACPGIMRPGSTSLPETPRLFPllplrplgpgrmvshTPAPPASFPVPYLPGDPGAPcSSVLPTTGILTPHPGPQDSW 994
Cdd:pfam03154  467 FVPGGPPPITPPSGPPTSTSSAMP---------------GIQPPSSASVSSSGPVPAAV-SCPLPPVQIKEEALDEAEEP 530

                          250
                   ....*....|....*..
gi 14149696    995 KEAPAPrgnlQRNKLPE 1011
Cdd:pfam03154  531 ESPPPP----PRSPSPE 543
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 819-1052 1.85e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.47  E-value: 1.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   819 SQPSHQVPTPSPRPRvFTPQSSPAMPLAPSHPsPYQGPRTQNISDYRAPGPQaiqplPLSPGVRPASSQPQLLGGQRVQV 898
Cdd:PHA03307   73 PGPGTEAPANESRST-PTWSLSTLAPASPARE-GSPTPPGPSSPDPPPPTPP-----PASPPPSPAPDLSEMLRPVGSPG 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   899 PNPVGFPGTWPLPGSPLPMA---CPGIMRPgSTSLPETPRLFPLLPLRPLGPGRMVSHTPAPPAsfpvPYLPGDPGAPCS 975
Cdd:PHA03307  146 PPPAASPPAAGASPAAVASDaasSRQAALP-LSSPEETARAPSSPPAEPPPSTPPAAASPRPPR----RSSPISASASSP 220

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 14149696   976 SVLPT-TGILTPHPGPQDSWKEAPAPRGNLQRNKLPETfmPPAPITAPVMSLTPElQGILPSQPPVSSVSHAPPGVPG 1052
Cdd:PHA03307  221 APAPGrSAADDAGASSSDSSSSESSGCGWGPENECPLP--RPAPITLPTRIWEAS-GWNGPSSRPGPASSSSSPRERS 295
PHA03378 PHA03378
EBNA-3B; Provisional
 867-1076 1.94e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 42.36  E-value: 1.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   867 PGPQAIQPLPLSPGVRPASSQPQLlggqrVQVPNPVGFPGT-------------------WPLPGSPLPMAcPGIMRPGS 927
Cdd:PHA03378  569 LGPLQIQPLTSPTTSQLASSAPSY-----AQTPWPVPHPSQtpeppttqshipetsaprqWPMPLRPIPMR-PLRMQPIT 642

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   928 TSL---PETPRLFPLLPLRPLGPGRMVSHTPAPP------ASFPVPYLPGD---PGAPCSSVLPTTGILTPHPGPQDSWK 995
Cdd:PHA03378  643 FNVlvfPTPHQPPQVEITPYKPTWTQIGHIPYQPsptganTMLPIQWAPGTmqpPPRAPTPMRPPAAPPGRAQRPAAATG 722

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   996 EAPAPRGNLQRNKLPETfmppAPITAPVMSLTPElqgilPSQPPVSSVSHAPP--GVPGELSLQLQ-HLPPEKMERKELP 1072
Cdd:PHA03378  723 RARPPAAAPGRARPPAA----APGRARPPAAAPG-----RARPPAAAPGRARPpaAAPGAPTPQPPpQAPPAPQQRPRGA 793


                  ....
gi 14149696  1073 PEHQ 1076
Cdd:PHA03378  794 PTPQ 797
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 252-335 2.09e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.55  E-value: 2.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696  252 PLKVLESHSRGILSVSWSqADAELLLTSAKDSQILCRNLGSSEVVYKLPTQSSWCFDVQWCPRDPSVFSaASFNGWISLY 331
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFS-PDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLAS-GSSDKTIRLW 78


                 ....
gi 14149696  332 SVMG 335
Cdd:cd00200   79 DLET 82
half-pint TIGR01645
poly-U binding splicing factor, half-pint family; The proteins represented by this model ...
 829-1070 3.00e-03

poly-U binding splicing factor, half-pint family; The proteins represented by this model contain three RNA recognition motifs (rrm: pfam00076) and have been characterized as poly-pyrimidine tract binding proteins associated with RNA splicing factors. In the case of PUF60 (GP|6176532), in complex with p54, and in the presence of U2AF, facilitates association of U2 snRNP with pre-mRNA.


Pssm-ID: 130706 [Multi-domain]  Cd Length: 612  Bit Score: 41.59  E-value: 3.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696    829 SPRPRVFTPQSSPAMPLAPSHPSpyqGPRTQNISDYRAPGPQAIQPLPLSPGVRPASSQPQLLGGQRVqvpnpVGFPGTW 908
Cdd:TIGR01645  283 TPPDALLQPATVSAIPAAAAVAA---AAATAKIMAAEAVAGAAVLGPRAQSPATPSSSLPTDIGNKAV-----VSSAKKE 354

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696    909 PLPGSPLPMACPGIMRPGSTSLPetprlfpllplrplgpgrmvshTPAPPASFPVPYLPGDPGApcssVLPTtgilTPHP 988
Cdd:TIGR01645  355 AEEVPPLPQAAPAVVKPGPMEIP----------------------TPVPPPGLAIPSLVAPPGL----VAPT----EINP 404

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696    989 GPQDSwkeapaPRGNLQRNKLPETFMPpapitapvmsLTPELQGILPSQPPVSSVSHAPPGVPGELSLQLQHLPPEKMER 1068
Cdd:TIGR01645  405 SFLAS------PRKKMKREKLPVTFGA----------LDDTLAWKEPSKEDQTSEDGKMLAIMGEAAAALALEPKKKKKE 468


                   ..
gi 14149696   1069 KE 1070
Cdd:TIGR01645  469 KE 470
PHA03247 PHA03247
large tegument protein UL36; Provisional
 758-1049 3.28e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 3.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   758 ATAMSF-LPRDCAQPPVQQLRDRLFHAQGSAVLGQQSPPFPFPRIVVGATLHSKETssyrLGSQPSHQVPTPSPRPRVFT 836
Cdd:PHA03247  198 AGAMVFfVPSGPGPAAPADLTAAALHLYGASETYLQDEPFVERRVVISHPLRGDIA----APAPPPVVGEGADRAPETAR 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   837 PQSSPAMPLAPSHPSPYQGPRTQNISDYRAPGPQAIQPLPLSPGVRPASSQPQL---LGGQRVQVP-------NPVGFPG 906
Cdd:PHA03247  274 GATGPPPPPEAAAPNGAAAPPDGVWGAALAGAPLALPAPPDPPPPAPAGDAEEEddeDGAMEVVSPlprprqhYPLGFPK 353

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   907 ----TWPlPGSPLPMACPGIMRPGSTSLPETPRLFPLLPLRPLGPGRMVSHTPAP--PASFPVPyLPGDPGAPCSSVLPT 980
Cdd:PHA03247  354 rrrpTWT-PPSSLEDLSAGRHHPKRASLPTRKRRSARHAATPFARGPGGDDQTRPaaPVPASVP-TPAPTPVPASAPPPP 431

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 14149696   981 TgilTPHPGPQDSWKEAPAPRGNLQrnklPETFMPPAPITAPVMSLTPELQGILPSQPPvssvshAPPG 1049
Cdd:PHA03247  432 A---TPLPSAEPGSDDGPAPPPERQ----PPAPATEPAPDDPDDATRKALDALRERRPP------EPPG 487
PHA03379 PHA03379
EBNA-3A; Provisional
 804-1081 7.25e-03

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 40.43  E-value: 7.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   804 GATLHSKET---SSYRLGSQPSHQVPTPSPRPRVFTPQSSPAMPLAPSHPSPYQGPRTQNISDYRAPGPQAIQPLPLSPg 880
Cdd:PHA03379  396 KLTERAREAlekASEPTYGTPRPPVEKPRPEVPQSLETATSHGSAQVPEPPPVHDLEPGPLHDQHSMAPCPVAQLPPGP- 474

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   881 VRPASSQPQLLGgqrvQVPNPVGFPGTWPLPGSPlpmacpgIMRPGSTSLPETPRLFPLLplrplgpgrmVSHTPAPPAS 960
Cdd:PHA03379  475 LQDLEPGDQLPG----VVQDGRPACAPVPAPAGP-------IVRPWEASLSQVPGVAFAP----------VMPQPMPVEP 533

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696   961 FPVPYLPGD-PGAPCSSVLPTTGILTPHPGPQDSWKEAPAPrgnlqrnklpetfMPPAPITAPV-MSLTPELQGILP-SQ 1037
Cdd:PHA03379  534 VPVPTVALErPVCPAPPLIAMQGPGETSGIVRVRERWRPAP-------------WTPNPPRSPSqMSVRDRLARLRAeAQ 600

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 14149696  1038 PPVSSVSHAPPgvpgelslQLQHLPPEKMERKELPPEHQSLKSS 1081
Cdd:PHA03379  601 PYQASVEVQPP--------QLTQVSPQQPMEYPLEPEQQMFPGS 636
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 736-1074 8.58e-03

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 40.05  E-value: 8.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696  736 PGPATTYRVTQYANLLAAQGS--------LATAMSFLPRDCAQPPVQQLRDRLFHAQGSavLGQQSPPFPFPRIVVGATL 807
Cdd:COG5180  133 PKAKVTREATSASAGVALAAAllqrsdpiLAKDPDGDSASTLPPPAEKLDKVLTEPRDA--LKDSPEKLDRPKVEVKDEA 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696  808 HSKETSSYRLGSQPSHQVPTPSPRPRVFTPQSSPAMPLAPSHPSPyqGPRTQNISDYRAPGPQAIQPLPLSPGVRPASSQ 887
Cdd:COG5180  211 QEEPPDLTGGADHPRPEAASSPKVDPPSTSEARSRPATVDAQPEM--RPPADAKERRRAAIGDTPAAEPPGLPVLEAGSE 288

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696  888 PQLlGGQRVQVPNPVGFPGTWPLPGSPLPMACPGIMRPGSTSLPEtprLFPLLPLRPLGPGRMVSHTPA--PPASFPVPY 965
Cdd:COG5180  289 PQS-DAPEAETARPIDVKGVASAPPATRPVRPPGGARDPGTPRPG---QPTERPAGVPEAASDAGQPPSayPPAEEAVPG 364

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696  966 LPGDPGAP--CSSVLPTTGILTPHPGPQDSWKEAPAPRGNLQRNKLPEtFMPPAPITAPVMSLTPELQGILPSQPPVSSV 1043
Cdd:COG5180  365 KPLEQGAPrpGSSGGDGAPFQPPNGAPQPGLGRRGAPGPPMGAGDLVQ-AALDGGGRETASLGGAAGGAGQGPKADFVPG 443

                        330       340       350
                 ....*....|....*....|....*....|.
gi 14149696 1044 SHAPPGVPGELSLQLQHLPPEKMERKELPPE 1074
Cdd:COG5180  444 DAESVSGPAGLADQAGAAASTAMADFVAPVT 474
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 704-901 8.74e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 40.40  E-value: 8.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696    704 QALSPMALQDLMEKVMVLNRSLEQLRGPHGVSPGPATTYRVTQYANLLAAQGSLATAMSFLPRDCAQPPVQQLRDRLFHA 783
Cdd:pfam09770  179 PAAQPASLPAPSRKMMSLEEVEAAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPG 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149696    784 QGSAVLGQQSPPFPFPrivvgatlhsketssyrlgsqpshQVPTPSPRPR-VFTPQSSPAMPLAPSHpsPYQGPRTQniS 862
Cdd:pfam09770  259 QGHPVTILQRPQSPQP------------------------DPAQPSIQPQaQQFHQQPPPVPVQPTQ--ILQNPNRL--S 310

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 14149696    863 DYRAPGPQAIQPLPLSPGVRPASSQPQLLGGQRVQVPNP 901
Cdd:pfam09770  311 AARVGYPQNPQPGVQPAPAHQAHRQQGSFGRQAPIITHP 349
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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