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Conserved domains on  [gi|46094076|ref|NP_056331|]
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tsukushi isoform b precursor [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
84-307 5.91e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.52  E-value: 5.91e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076  84 TTLAGLDLSHNlltsispTAFSRLRYLESLDLSHNGLTALPAE--SFTSspLSDVNLSHNQLREVSvSAFTTHSQGRALh 161
Cdd:COG4886  96 TNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEElaNLTN--LKELDLSNNQLTDLP-EPLGNLTNLKSL- 164

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076 162 vDLSHNLIHRLvphpTRAGLPAPTIQSLNLAWNRLHAVPN-LRDLP-LRYLSLDGNPLAVIgPGAFAGLGGLTHLSLAS- 238
Cdd:COG4886 165 -DLSNNQLTDL----PEELGNLTNLKELDLSNNQITDLPEpLGNLTnLEELDLSGNQLTDL-PEPLANLTNLETLDLSNn 238

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076 239 -LQRLPELApsgfrELPGLQVLDLSGNpKLNWAGAEvfSGLSSLQELDLSGTNLVPLPEALLLHLPALQS 307
Cdd:COG4886 239 qLTDLPELG-----NLTNLEELDLSNN-QLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNS 300
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
84-307 5.91e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.52  E-value: 5.91e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076  84 TTLAGLDLSHNlltsispTAFSRLRYLESLDLSHNGLTALPAE--SFTSspLSDVNLSHNQLREVSvSAFTTHSQGRALh 161
Cdd:COG4886  96 TNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEElaNLTN--LKELDLSNNQLTDLP-EPLGNLTNLKSL- 164

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076 162 vDLSHNLIHRLvphpTRAGLPAPTIQSLNLAWNRLHAVPN-LRDLP-LRYLSLDGNPLAVIgPGAFAGLGGLTHLSLAS- 238
Cdd:COG4886 165 -DLSNNQLTDL----PEELGNLTNLKELDLSNNQITDLPEpLGNLTnLEELDLSGNQLTDL-PEPLANLTNLETLDLSNn 238

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076 239 -LQRLPELApsgfrELPGLQVLDLSGNpKLNWAGAEvfSGLSSLQELDLSGTNLVPLPEALLLHLPALQS 307
Cdd:COG4886 239 qLTDLPELG-----NLTNLEELDLSNN-QLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNS 300
LRR_8 pfam13855
Leucine rich repeat;
89-143 9.42e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 9.42e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 46094076    89 LDLSHNLLTSISPTAFSRLRYLESLDLSHNGLTALPAESFTSSP-LSDVNLSHNQL 143
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPsLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 63-174 2.10e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.09  E-value: 2.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076   63 LDLSSNRL-EMVNESVLAGPgytTLAGLDLSHNLLTSISPTAFSRLRYLESLDLSHNGLTALPAESFTSSP-LSDVNLSH 140
Cdd:PLN00113 480 LDLSRNQFsGAVPRKLGSLS---ELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPvLSQLDLSQ 556

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 46094076  141 NQLrevsvSAFTTHSQGRA---LHVDLSHNLIHRLVP 174
Cdd:PLN00113 557 NQL-----SGEIPKNLGNVeslVQVNISHNHLHGSLP 588
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 38-291 1.81e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.89  E-value: 1.81e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076  38 SLTRVDCSGLGPHIMPVPiplDTAHLDLSSNRLEMVNESV-LAGPGYTTLAGL---DLSHNLLTSISPTAFSRLR---YL 110
Cdd:cd00116  34 TLGEEAAKALASALRPQP---SLKELCLSLNETGRIPRGLqSLLQGLTKGCGLqelDLSDNALGPDGCGVLESLLrssSL 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076 111 ESLDLSHNGL----TALPAESFTSSP--LSDVNLSHNQLrevsvsaftTHSQGRALHVDLSHNlihrlvphptraglpaP 184
Cdd:cd00116 111 QELKLNNNGLgdrgLRLLAKGLKDLPpaLEKLVLGRNRL---------EGASCEALAKALRAN----------------R 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076 185 TIQSLNLAWNRLHA------VPNLRDLP-LRYLSLDGNPLAVIGPGAFAGlgglthlslaslqrlpelapsGFRELPGLQ 257
Cdd:cd00116 166 DLKELNLANNGIGDagiralAEGLKANCnLEVLDLNNNGLTDEGASALAE---------------------TLASLKSLE 224

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 46094076 258 VLDLSGNPKLNWAGAEVFSGL----SSLQELDLSGTNL 291
Cdd:cd00116 225 VLNLGDNNLTDAGAAALASALlspnISLLTLSLSCNDI 262
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
84-307 5.91e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.52  E-value: 5.91e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076  84 TTLAGLDLSHNlltsispTAFSRLRYLESLDLSHNGLTALPAE--SFTSspLSDVNLSHNQLREVSvSAFTTHSQGRALh 161
Cdd:COG4886  96 TNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEElaNLTN--LKELDLSNNQLTDLP-EPLGNLTNLKSL- 164

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076 162 vDLSHNLIHRLvphpTRAGLPAPTIQSLNLAWNRLHAVPN-LRDLP-LRYLSLDGNPLAVIgPGAFAGLGGLTHLSLAS- 238
Cdd:COG4886 165 -DLSNNQLTDL----PEELGNLTNLKELDLSNNQITDLPEpLGNLTnLEELDLSGNQLTDL-PEPLANLTNLETLDLSNn 238

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076 239 -LQRLPELApsgfrELPGLQVLDLSGNpKLNWAGAEvfSGLSSLQELDLSGTNLVPLPEALLLHLPALQS 307
Cdd:COG4886 239 qLTDLPELG-----NLTNLEELDLSNN-QLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNS 300
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
63-314 1.09e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.75  E-value: 1.09e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076  63 LDLSSNRLEMVNESVlagPGYTTLAGLDLSHNLLTSIsPTAFSRLRYLESLDLSHNGLTALPAESFTSSPLSDVNLSHNQ 142
Cdd:COG4886 118 LDLSGNQLTDLPEEL---ANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQ 193

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076 143 LREVSvSAFtthSQGRAL-HVDLSHNLIHRLvPHPTrAGLPAptIQSLNLAWNRLHAVPNLRDLP-LRYLSLDGNPLAVI 220
Cdd:COG4886 194 ITDLP-EPL---GNLTNLeELDLSGNQLTDL-PEPL-ANLTN--LETLDLSNNQLTDLPELGNLTnLEELDLSNNQLTDL 265

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076 221 GPgaFAGLGGLTHLSLaSLQRLPELAPSGFRELPGLQVLDLSGNPKLNWAGAEVFSGLSSLQELDLSGTNLVPLPEALLL 300
Cdd:COG4886 266 PP--LANLTNLKTLDL-SNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342

                       250
                ....*....|....
gi 46094076 301 HLPALQSVSVGQDV 314
Cdd:COG4886 343 SLSLLALLTLLLLL 356
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
58-310 2.65e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.51  E-value: 2.65e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076  58 LDTAHLDLSSNRLEMVNESVLAGPGYTTLAGLDLSHNLLTSISPTAFSRLRYLESLDLSHNgltalpAESFTSSPLSDVN 137
Cdd:COG4886  46 LLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLD 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076 138 LSHNQLREVSVSAftthSQGRAL-HVDLSHNLIHRLVPhptraGLPA-PTIQSLNLAWNRLHAVPN-LRDLP-LRYLSLD 213
Cdd:COG4886 120 LSGNQLTDLPEEL----ANLTNLkELDLSNNQLTDLPE-----PLGNlTNLKSLDLSNNQLTDLPEeLGNLTnLKELDLS 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076 214 GNPLAVIgPGAFAGLGGLTHLSLAS--LQRLPElapsGFRELPGLQVLDLSGNP--KLNWagaevFSGLSSLQELDLSGT 289
Cdd:COG4886 191 NNQITDL-PEPLGNLTNLEELDLSGnqLTDLPE----PLANLTNLETLDLSNNQltDLPE-----LGNLTNLEELDLSNN 260

                       250       260
                ....*....|....*....|.
gi 46094076 290 NLVPLPEalLLHLPALQSVSV 310
Cdd:COG4886 261 QLTDLPP--LANLTNLKTLDL 279
LRR_8 pfam13855
Leucine rich repeat;
89-143 9.42e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.07  E-value: 9.42e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 46094076    89 LDLSHNLLTSISPTAFSRLRYLESLDLSHNGLTALPAESFTSSP-LSDVNLSHNQL 143
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPsLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 63-174 2.10e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.09  E-value: 2.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076   63 LDLSSNRL-EMVNESVLAGPgytTLAGLDLSHNLLTSISPTAFSRLRYLESLDLSHNGLTALPAESFTSSP-LSDVNLSH 140
Cdd:PLN00113 480 LDLSRNQFsGAVPRKLGSLS---ELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPvLSQLDLSQ 556

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 46094076  141 NQLrevsvSAFTTHSQGRA---LHVDLSHNLIHRLVP 174
Cdd:PLN00113 557 NQL-----SGEIPKNLGNVeslVQVNISHNHLHGSLP 588
LRR_8 pfam13855
Leucine rich repeat;
63-120 4.15e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 4.15e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 46094076    63 LDLSSNRLEMVNESVLAGPgyTTLAGLDLSHNLLTSISPTAFSRLRYLESLDLSHNGL 120
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGL--SNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
62-261 1.08e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.48  E-value: 1.08e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076  62 HLDLSSNRLEMVNESVlagPGYTTLAGLDLSHNLLTSISptAFSRLRYLESLDLSHNGLTALPAESFTSSpLSDVNLSHN 141
Cdd:COG4886 209 ELDLSGNQLTDLPEPL---ANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLANLTN-LKTLDLSNN 282

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076 142 QLREVSVSAFTTHSQGRALHVDLSHNLIHRLVPHPTRAGLPAPTIQSLNLAWNRLHAVPNLRDLPLRYLSLDGNPLAVIG 221
Cdd:COG4886 283 QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLL 362

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 46094076 222 PGAFAGLGGLTHLSLASLQRLPELAPSGFRELPGLQVLDL 261
Cdd:COG4886 363 LTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLL 402
LRR_8 pfam13855
Leucine rich repeat;
207-265 2.79e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 2.79e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 46094076   207 LRYLSLDGNPLAVIGPGAFAGLGGLTHLSLaSLQRLPELAPSGFRELPGLQVLDLSGNP 265
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDL-SNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
52-265 6.89e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 54.32  E-value: 6.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076   52 MPVPIPLDTAHLDLSSNRLEMVNESVlagPgyTTLAGLDLSHNLLTSISPTAFSRLRYlesLDLSHNGLTALPAEsfTSS 131
Cdd:PRK15370 235 IPATLPDTIQEMELSINRITELPERL---P--SALQSLDLFHNKISCLPENLPEELRY---LSVYDNSIRTLPAH--LPS 304

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076  132 PLSDVNLSHNQLrevsvsaftthsqgRALHVDLSHNLIHRLVPHPTRAGLPA---PTIQSLNLAWNRLHAVPNLRDLPLR 208
Cdd:PRK15370 305 GITHLNVQSNSL--------------TALPETLPPGLKTLEAGENALTSLPAslpPELQVLDVSKNQITVLPETLPPTIT 370

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 46094076  209 YLSLDGNPLAVIGPGAFAGLGGLtHLSLASLQRLPELAPSGFRELPGLQVLDLSGNP 265
Cdd:PRK15370 371 TLDVSRNALTNLPENLPAALQIM-QASRNNLVRLPESLPHFRGEGPQPTRIIVEYNP 426
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
113-328 1.12e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.55  E-value: 1.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076  113 LDLSHNGLTALPA---ESFTSSPLSDVNLS------HNQLREVSVSAFTTHSQGRAL-----HVDLSHNLIHRLVPHptr 178
Cdd:PRK15370 183 LRLKILGLTTIPAcipEQITTLILDNNELKslpenlQGNIKTLYANSNQLTSIPATLpdtiqEMELSINRITELPER--- 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076  179 agLPApTIQSLNLAWNRLHAVPNlrDLP--LRYLSLDGNPLAVIgPGAFAGlgGLTHLSLA--SLQRLPELAPSGFREL- 253
Cdd:PRK15370 260 --LPS-ALQSLDLFHNKISCLPE--NLPeeLRYLSVYDNSIRTL-PAHLPS--GITHLNVQsnSLTALPETLPPGLKTLe 331

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076  254 --------------PGLQVLDLSGN-----PKlnwagaevfSGLSSLQELDLSGTNLVPLPEALLLHLPALQSvSVGQDV 314
Cdd:PRK15370 332 agenaltslpaslpPELQVLDVSKNqitvlPE---------TLPPTITTLDVSRNALTNLPENLPAALQIMQA-SRNNLV 401

                        250
                 ....*....|....*...
gi 46094076  315 RCRR----LVREGTYPRR 328
Cdd:PRK15370 402 RLPEslphFRGEGPQPTR 419
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
40-298 9.88e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.47  E-value: 9.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076   40 TRVDCSGLGPHIMPVPIPLDTAHLDLSSNRLE-------------MVNESVLAGPGYT---TLAGLDLSHNLLTSIS--- 100
Cdd:PRK15370 181 TELRLKILGLTTIPACIPEQITTLILDNNELKslpenlqgniktlYANSNQLTSIPATlpdTIQEMELSINRITELPerl 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076  101 PTAfsrlryLESLDLSHNGLTALPAesftssplsdvNLShNQLREVSVsaftTHSQGRALHVDLSHNLIHRLVPHPTRAG 180
Cdd:PRK15370 261 PSA------LQSLDLFHNKISCLPE-----------NLP-EELRYLSV----YDNSIRTLPAHLPSGITHLNVQSNSLTA 318

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076  181 LPA---PTIQSLNLAWNRLHAVPNLRDLPLRYLSLDGNPLAVigpgafaglgglthlslaslqrLPELAPsgfrelPGLQ 257
Cdd:PRK15370 319 LPEtlpPGLKTLEAGENALTSLPASLPPELQVLDVSKNQITV----------------------LPETLP------PTIT 370

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 46094076  258 VLDLSGNPKLNWAgaevfSGL-SSLQELDLSGTNLVPLPEAL 298
Cdd:PRK15370 371 TLDVSRNALTNLP-----ENLpAALQIMQASRNNLVRLPESL 407
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 38-291 1.81e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.89  E-value: 1.81e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076  38 SLTRVDCSGLGPHIMPVPiplDTAHLDLSSNRLEMVNESV-LAGPGYTTLAGL---DLSHNLLTSISPTAFSRLR---YL 110
Cdd:cd00116  34 TLGEEAAKALASALRPQP---SLKELCLSLNETGRIPRGLqSLLQGLTKGCGLqelDLSDNALGPDGCGVLESLLrssSL 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076 111 ESLDLSHNGL----TALPAESFTSSP--LSDVNLSHNQLrevsvsaftTHSQGRALHVDLSHNlihrlvphptraglpaP 184
Cdd:cd00116 111 QELKLNNNGLgdrgLRLLAKGLKDLPpaLEKLVLGRNRL---------EGASCEALAKALRAN----------------R 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076 185 TIQSLNLAWNRLHA------VPNLRDLP-LRYLSLDGNPLAVIGPGAFAGlgglthlslaslqrlpelapsGFRELPGLQ 257
Cdd:cd00116 166 DLKELNLANNGIGDagiralAEGLKANCnLEVLDLNNNGLTDEGASALAE---------------------TLASLKSLE 224

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 46094076 258 VLDLSGNPKLNWAGAEVFSGL----SSLQELDLSGTNL 291
Cdd:cd00116 225 VLNLGDNNLTDAGAAALASALlspnISLLTLSLSCNDI 262
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 62-217 1.05e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 47.09  E-value: 1.05e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076  62 HLDLSSNRLEmvNESVLAGPGY----TTLAGLDLSHNLLT-----SISpTAFSRLRYLESLDLSHNGLTALPAESF---- 128
Cdd:COG5238 240 TLDLSNNQIG--DEGVIALAEAlknnTTVETLYLSGNQIGaegaiALA-KALQGNTTLTSLDLSVNRIGDEGAIALaegl 316

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076 129 -TSSPLSDVNLSHNQLREVSVSAFTTHSQ-GRALH-VDLSHN---------LIHRLVPHptraglpaPTIQSLNLAWNRL 196
Cdd:COG5238 317 qGNKTLHTLNLAYNGIGAQGAIALAKALQeNTTLHsLDLSDNqigdegaiaLAKYLEGN--------TTLRELNLGKNNI 388

                       170       180
                ....*....|....*....|....*..
gi 46094076 197 HAV------PNLRDLPLRYLSLDGNPL 217
Cdd:COG5238 389 GKQgaealiDALQTNRLHTLILDGNLI 415
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 86-298 1.29e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.15  E-value: 1.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076   86 LAGLDLS-HNLLTSISPTAFsRLRYLESLDLSHNGLTA-LPAESF-TSSPLSDVNLSHNQLREVSVSAFTTHSQGralhV 162
Cdd:PLN00113  71 VVSIDLSgKNISGKISSAIF-RLPYIQTINLSNNQLSGpIPDDIFtTSSSLRYLNLSNNNFTGSIPRGSIPNLET----L 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076  163 DLSHNLIHRLVPhptraglpaptiQSLNLAWNrlhavpnlrdlpLRYLSLDGNPLAVIGPGAFAGLGGLTHLSLASLQRL 242
Cdd:PLN00113 146 DLSNNMLSGEIP------------NDIGSFSS------------LKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLV 201

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076  243 PELaPSGFRELPGLQVLDLSGNpklNWAGaEV---FSGLSSLQELDLSGTNLV-PLPEAL 298
Cdd:PLN00113 202 GQI-PRELGQMKSLKWIYLGYN---NLSG-EIpyeIGGLTSLNHLDLVYNNLTgPIPSSL 256
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 82-197 1.99e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.38  E-value: 1.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076   82 GYTTLAGLDLSHNLLTSISPTAFSRLRYLESLDLSHNGLTA-LPAESFTSSPLSDVNLSHNQLR---EVSVSAFTTHSQg 157
Cdd:PLN00113 473 GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGeIPDELSSCKKLVSLDLSHNQLSgqiPASFSEMPVLSQ- 551

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 46094076  158 ralhVDLSHNLIHRLVphPTRAGLPAPTIQsLNLAWNRLH 197
Cdd:PLN00113 552 ----LDLSQNQLSGEI--PKNLGNVESLVQ-VNISHNHLH 584
LRR_8 pfam13855
Leucine rich repeat;
108-169 1.00e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 1.00e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 46094076   108 RYLESLDLSHNGLTALPAESFTS-SPLSDVNLSHNQLREVSVSAFtthSQGRAL-HVDLSHNLI 169
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGlSNLKVLDLSNNLLTTLSPGAF---SGLPSLrYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
254-307 2.47e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 2.47e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 46094076   254 PGLQVLDLSGNpKLNWAGAEVFSGLSSLQELDLSGTNLVPLPEALLLHLPALQS 307
Cdd:pfam13855   1 PNLRSLDLSNN-RLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRY 53
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 63-264 3.43e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 3.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076   63 LDLSSNRLEMVNESVLAGPGYttLAGLDLSHNLLTSISPTAFSRLRYLESLDLSHNGLTALPAESFTSSPLSD-VNLSHN 141
Cdd:PLN00113 361 LDLSTNNLTGEIPEGLCSSGN--LFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYfLDISNN 438

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076  142 QLREVSVSAFTTHSQGRALhvDLSHNLIHRLVPHPTRAglpaPTIQSLNLAWNRLH-AVPN-LRDLP-LRYLSLDGNPLA 218
Cdd:PLN00113 439 NLQGRINSRKWDMPSLQML--SLARNKFFGGLPDSFGS----KRLENLDLSRNQFSgAVPRkLGSLSeLMQLKLSENKLS 512

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 46094076  219 VIGPGAFAGLGGLTHLSLaSLQRLPELAPSGFRELPGLQVLDLSGN 264
Cdd:PLN00113 513 GEIPDELSSCKKLVSLDL-SHNQLSGQIPASFSEMPVLSQLDLSQN 557
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
181-311 4.90e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.84  E-value: 4.90e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076 181 LPAPTIQSLNLAWNRLHAVPNLRDLPLRYLSLDGNPLAVIGPGAFAGLGGLTHLSLASLQRLPELApsgfrELPGLQVLD 260
Cdd:COG4886  45 LLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELS-----NLTNLESLD 119

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 46094076 261 LSGNpKLNWAGAEvFSGLSSLQELDLSGTNLVPLPEAlLLHLPALQSVSVG 311
Cdd:COG4886 120 LSGN-QLTDLPEE-LANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLS 167
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 89-214 2.80e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 2.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076   89 LDLSHNLLTSISPTAFSRLRYLESLDLSHNGLTALPAESFTSSPLSDVNLSHNQLREVSVSAFTTHSQgrALHVDLSHNL 168
Cdd:PLN00113 433 LDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSE--LMQLKLSENK 510

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 46094076  169 IHRLVPHPTRAglpAPTIQSLNLAWNRLHA--------VPNLRDLPLRYLSLDG 214
Cdd:PLN00113 511 LSGEIPDELSS---CKKLVSLDLSHNQLSGqipasfseMPVLSQLDLSQNQLSG 561
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 89-141 3.80e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.23  E-value: 3.80e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 46094076  89 LDLSHNLLTSISPtaFSRLRYLESLDLSHNGLTALP--AESFTSSP-LSDVNLSHN 141
Cdd:cd21340 125 LNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWPsLRELDLTGN 178
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 183-288 6.12e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.46  E-value: 6.12e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076 183 APTIQSLNLAWNRLHAVPNLRDLP-LRYLSLDGNPLAVIgpgafAGLGG---LTHLSLASlQRLPE-------------L 245
Cdd:cd21340  45 LTNLTHLYLQNNQIEKIENLENLVnLKKLYLGGNRISVV-----EGLENltnLEELHIEN-QRLPPgekltfdprslaaL 118

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 46094076 246 APS---------------GFRELPGLQVLDLSGNPKLNWAG-AEVFSGLSSLQELDLSG 288
Cdd:cd21340 119 SNSlrvlnisgnnidslePLAPLRNLEQLDASNNQISDLEElLDLLSSWPSLRELDLTG 177
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 89-218 9.92e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.07  E-value: 9.92e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094076  89 LDLSHNLLTSISPtaFSRLRYLESLDLSHN------GLTALPAesftsspLSDVNLSHNQLREVSVSAF---TTHSQGRA 159
Cdd:cd21340  51 LYLQNNQIEKIEN--LENLVNLKKLYLGGNrisvveGLENLTN-------LEELHIENQRLPPGEKLTFdprSLAALSNS 121

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 46094076 160 LHV-DLSHNLIHRLVPhptRAGLPAptIQSLNLAWNRLHAVPNLRDL-----PLRYLSLDGNPLA 218
Cdd:cd21340 122 LRVlNISGNNIDSLEP---LAPLRN--LEQLDASNNQISDLEELLDLlsswpSLRELDLTGNPVC 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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