NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|260656052|ref|NP_056512|]
View 

4-hydroxybenzoate polyprenyltransferase, mitochondrial isoform 1 [Homo sapiens]

Protein Classification

UbiA prenyltransferase family protein( domain architecture ID 91)

UbiA prenyltransferase family protein, an aromatic prenyltransferase, plays an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PT_UbiA super family cl00337
UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA ...
 118-403 1.50e-153

UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


The actual alignment was detected with superfamily member PLN02809:

Pssm-ID: 469727  Cd Length: 289  Bit Score: 435.66  E-value: 1.50e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 118 PRPLQPYLRLMRLDKPIGTWLLYLPCTWSIGLAAEPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANR 197
Cdd:PLN02809   3 PPSLRPYAKLARLDKPIGTWLLAWPCMWSIALAAPPGSLPDLKMLALFGCGALLLRGAGCTINDLLDRDIDKKVERTKLR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 198 PIAAGDISTFQSFVFLGGQLTLALGVLLCLNYYSIALGAGSLLLVITYPLMKRISYWPQLALGLTFNWGALLGWSAIKGS 277
Cdd:PLN02809  83 PIASGALTPFQGVGFLGAQLLLGLGILLQLNNYSRILGASSLLLVFTYPLMKRFTFWPQAFLGLTFNWGALLGWAAVKGS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 278 CDPSVCLPLYFSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFSVAMLGALSLVGVNSGQTAPYYAAL 357
Cdd:PLN02809 163 LDPAVVLPLYASGVCWTLVYDTIYAHQDKEDDLKVGVKSTALRFGDDTKLWLTGFGAASIGGLALSGYNAGLGWPYYAGL 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 260656052 358 GAVGAHLTHQIYTLDIHRPEDCWNKFISNRTLGLIVFLGIVLGNLW 403
Cdd:PLN02809 243 AAAAGHLAWQIQTVDLSSRADCNRKFVSNKWFGAIVFAGIVLGKLF 288
 
Name Accession Description Interval E-value
PLN02809 PLN02809
4-hydroxybenzoate nonaprenyltransferase
 118-403 1.50e-153

4-hydroxybenzoate nonaprenyltransferase


Pssm-ID: 178405  Cd Length: 289  Bit Score: 435.66  E-value: 1.50e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 118 PRPLQPYLRLMRLDKPIGTWLLYLPCTWSIGLAAEPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANR 197
Cdd:PLN02809   3 PPSLRPYAKLARLDKPIGTWLLAWPCMWSIALAAPPGSLPDLKMLALFGCGALLLRGAGCTINDLLDRDIDKKVERTKLR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 198 PIAAGDISTFQSFVFLGGQLTLALGVLLCLNYYSIALGAGSLLLVITYPLMKRISYWPQLALGLTFNWGALLGWSAIKGS 277
Cdd:PLN02809  83 PIASGALTPFQGVGFLGAQLLLGLGILLQLNNYSRILGASSLLLVFTYPLMKRFTFWPQAFLGLTFNWGALLGWAAVKGS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 278 CDPSVCLPLYFSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFSVAMLGALSLVGVNSGQTAPYYAAL 357
Cdd:PLN02809 163 LDPAVVLPLYASGVCWTLVYDTIYAHQDKEDDLKVGVKSTALRFGDDTKLWLTGFGAASIGGLALSGYNAGLGWPYYAGL 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 260656052 358 GAVGAHLTHQIYTLDIHRPEDCWNKFISNRTLGLIVFLGIVLGNLW 403
Cdd:PLN02809 243 AAAAGHLAWQIQTVDLSSRADCNRKFVSNKWFGAIVFAGIVLGKLF 288
ubiA_proteo TIGR01474
4-hydroxybenzoate polyprenyl transferase, proteobacterial; This model represents a family of ...
 121-402 1.53e-149

4-hydroxybenzoate polyprenyl transferase, proteobacterial; This model represents a family of integral membrane proteins that condenses para-hydroxybenzoate with any of several polyprenyldiphosphates. Heterologous expression studies suggest that for, many but not all members, the activity seen (e.g. octaprenyltransferase in E. coli) reflects available host isoprenyl pools rather than enzyme specificity. A fairly deep split by both clustering (UPGMA) and phylogenetics (NJ tree) separates this group (mostly Proteobacterial and mitochondrial), with several characterized members, from another group (mostly archaeal and Gram-positive bacterial) lacking characterized members. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 130539  Cd Length: 281  Bit Score: 425.19  E-value: 1.53e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052  121 LQPYLRLMRLDKPIGTWLLYLPCTWSIGLAAEPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANRPIA 200
Cdd:TIGR01474   1 LLPYAKLMRADKPIGTLLLLWPCLWSLLLAAQAGGIPPLYLLGLFTVGAILMRGAGCVINDIWDRDFDPQVERTKSRPLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052  201 AGDISTFQSFVFLGGQLTLALGVLLCLNYYSIALGAGSLLLVITYPLMKRISYWPQLALGLTFNWGALLGWSAIKGSCDP 280
Cdd:TIGR01474  81 SGAVSVRQAILFLLVQLLVALGVLLQLNPLTILLGVASLALVATYPFMKRITYWPQLVLGLAFGWGALMGWAAVTGDLST 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052  281 sVCLPLYFSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFSVAMLGALSLVGVNSGQTAPYYAALGAV 360
Cdd:TIGR01474 161 -AAWVLYLANILWTLGYDTIYAMQDKEDDIKIGVKSTALRFGDNTKPWLGGLYALMILLLALAGLIAGLGPVYYLGLAAA 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 260656052  361 GAHLTHQIYTLDIHRPEDCWNKFISNRTLGLIVFLGIVLGNL 402
Cdd:TIGR01474 240 ALLLIRQIATLDIRDPENCLKLFKANNYVGLLLFAGIALGWL 281
PT_UbiA_COQ2 cd13959
4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known ...
 128-400 7.14e-121

4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known as Coq2, catalyzes the prenylation of p-hydroxybenzoate with an all-trans polyprenyl group, an important step in ubiquinone (CoQ) biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260122 [Multi-domain]  Cd Length: 272  Bit Score: 352.15  E-value: 7.14e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 128 MRLDKPIGTWLLYLPCTWSIGLAAEPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANRPIAAGDISTF 207
Cdd:cd13959    1 MRLDKPIGTLLLLPPALWGLLLAAGGLPLPLLKLLLLFLLGAFLMRSAGCTINDIADRDIDAKVPRTKNRPLASGAISVK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 208 QSFVFLGGQLTLALGVLLCLNYYSIALGAGSLLLVITYPLMKRISYWPQLALGLTFNWGALLGWSAIKGSCDPsVCLPLY 287
Cdd:cd13959   81 EALLFLAVQLLLGLALLLQLNPLTILLSPIALLLVLIYPLMKRFTYWPQLVLGLAFGWGPLMGWAAVTGSLPL-PALLLY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 288 FSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFSVAMLGALSLVGVNSGQTAPYYAALGAVgAHLTHQ 367
Cdd:cd13959  160 LAVIFWTAGYDTIYAHQDREDDRKIGVKSTAVLFGDRTKLILALLLHLFVALLLLAGGLAGLGWPYYLGLGAA-AHLLWQ 238

                        250       260       270
                 ....*....|....*....|....*....|....
gi 260656052 368 IYTLDIHRPE-DCWNKFISNRTLGLIVFLGIVLG 400
Cdd:cd13959  239 EHRLDLPDPLrSCLAFFLSNGWVGLLLFAGLLLD 272
UbiA COG0382
4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate ...
 122-399 8.62e-75

4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate polyprenyltransferase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440151  Cd Length: 280  Bit Score: 234.74  E-value: 8.62e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 122 QPYLRLMRLDKPIGTWLLYLPCTWSIGLAAepGCFPDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANRPIAA 201
Cdd:COG0382    1 RAYLRLLRLDRPIGILLLLWPTLWALFLAA--GGLPDLLLLLLAVLGTVLMRSAGYVINDYFDREIDRINERKPNRPLAS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 202 GDISTFQSFVFLGGQLTLALGVLLCLNYYSIALGAGSLLLVITYPL-MKRISYWPQLALGLTFNWGALLGWSAIKGSCDP 280
Cdd:COG0382   79 GRISLREALLLAIVLLLLALALALLLNPLTFLLALAALALAWAYSLfLKRFTLLGNLVLGLLFGLGILMGFAAVTGSLPL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 281 SVcLPLYFSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSG-FSVAMLGALSLVGVNSGQTAPYYAALGA 359
Cdd:COG0382  159 SA-WLLALAAFLWTLAYDTIYDLEDREGDRKIGIKTLAILFGVRDALIIAGvLYALAVLLLLLLGLLAGLGLLYLLGLLA 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 260656052 360 VGAHL-THQIYTLD--IHRPEDCWNKFISNRTLGLIVFLGIVL 399
Cdd:COG0382  238 ALLLLyLSQLWLLRprKKDPARALKLFKLNMLLGLLLFLGIAL 280
UbiA pfam01040
UbiA prenyltransferase family;
147-383 4.10e-46

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 159.31  E-value: 4.10e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052  147 IGLAAEPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANRPIAAGDISTFQSFVFLGGQLTLALGVLLC 226
Cdd:pfam01040   7 AGLALAAGGVPDLLLLLLALLGTVLARAAANALNDYYDRDIDAIMPRTPNRPLPSGRISPREALIFALVLLALGLLLLLL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052  227 LNYYSIALGAGSLLLVITYPL-MKRISYWPQLALGLTFNWGALLGWSAIKGSCDPSVcLPLYFSGVMWTLIYDTIYAHQD 305
Cdd:pfam01040  87 LNPLTALLGLAALLLYVLYTLrLKRRTLLGQLVGGLAFGLPPLLGWAAVTGSLSPLA-LLLALALFLWTWAIALANDLRD 165

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 260656052  306 KRDDVLIGLKSTALRFGENTKPWLS-GFSVAMLGALSLVGVNSGQTAPYYAALGAVGAHLTHQIYTLDIHRPEDCWNKF 383
Cdd:pfam01040 166 REDDRKAGIKTLPVVLGRKAARILLaLLLAVALLLLLLLLLLLLGGLYLLLALLLAALALLYAARLLRLRDPKKDAKAF 244
 
Name Accession Description Interval E-value
PLN02809 PLN02809
4-hydroxybenzoate nonaprenyltransferase
 118-403 1.50e-153

4-hydroxybenzoate nonaprenyltransferase


Pssm-ID: 178405  Cd Length: 289  Bit Score: 435.66  E-value: 1.50e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 118 PRPLQPYLRLMRLDKPIGTWLLYLPCTWSIGLAAEPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANR 197
Cdd:PLN02809   3 PPSLRPYAKLARLDKPIGTWLLAWPCMWSIALAAPPGSLPDLKMLALFGCGALLLRGAGCTINDLLDRDIDKKVERTKLR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 198 PIAAGDISTFQSFVFLGGQLTLALGVLLCLNYYSIALGAGSLLLVITYPLMKRISYWPQLALGLTFNWGALLGWSAIKGS 277
Cdd:PLN02809  83 PIASGALTPFQGVGFLGAQLLLGLGILLQLNNYSRILGASSLLLVFTYPLMKRFTFWPQAFLGLTFNWGALLGWAAVKGS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 278 CDPSVCLPLYFSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFSVAMLGALSLVGVNSGQTAPYYAAL 357
Cdd:PLN02809 163 LDPAVVLPLYASGVCWTLVYDTIYAHQDKEDDLKVGVKSTALRFGDDTKLWLTGFGAASIGGLALSGYNAGLGWPYYAGL 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 260656052 358 GAVGAHLTHQIYTLDIHRPEDCWNKFISNRTLGLIVFLGIVLGNLW 403
Cdd:PLN02809 243 AAAAGHLAWQIQTVDLSSRADCNRKFVSNKWFGAIVFAGIVLGKLF 288
ubiA_proteo TIGR01474
4-hydroxybenzoate polyprenyl transferase, proteobacterial; This model represents a family of ...
 121-402 1.53e-149

4-hydroxybenzoate polyprenyl transferase, proteobacterial; This model represents a family of integral membrane proteins that condenses para-hydroxybenzoate with any of several polyprenyldiphosphates. Heterologous expression studies suggest that for, many but not all members, the activity seen (e.g. octaprenyltransferase in E. coli) reflects available host isoprenyl pools rather than enzyme specificity. A fairly deep split by both clustering (UPGMA) and phylogenetics (NJ tree) separates this group (mostly Proteobacterial and mitochondrial), with several characterized members, from another group (mostly archaeal and Gram-positive bacterial) lacking characterized members. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 130539  Cd Length: 281  Bit Score: 425.19  E-value: 1.53e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052  121 LQPYLRLMRLDKPIGTWLLYLPCTWSIGLAAEPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANRPIA 200
Cdd:TIGR01474   1 LLPYAKLMRADKPIGTLLLLWPCLWSLLLAAQAGGIPPLYLLGLFTVGAILMRGAGCVINDIWDRDFDPQVERTKSRPLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052  201 AGDISTFQSFVFLGGQLTLALGVLLCLNYYSIALGAGSLLLVITYPLMKRISYWPQLALGLTFNWGALLGWSAIKGSCDP 280
Cdd:TIGR01474  81 SGAVSVRQAILFLLVQLLVALGVLLQLNPLTILLGVASLALVATYPFMKRITYWPQLVLGLAFGWGALMGWAAVTGDLST 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052  281 sVCLPLYFSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFSVAMLGALSLVGVNSGQTAPYYAALGAV 360
Cdd:TIGR01474 161 -AAWVLYLANILWTLGYDTIYAMQDKEDDIKIGVKSTALRFGDNTKPWLGGLYALMILLLALAGLIAGLGPVYYLGLAAA 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 260656052  361 GAHLTHQIYTLDIHRPEDCWNKFISNRTLGLIVFLGIVLGNL 402
Cdd:TIGR01474 240 ALLLIRQIATLDIRDPENCLKLFKANNYVGLLLFAGIALGWL 281
PT_UbiA_COQ2 cd13959
4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known ...
 128-400 7.14e-121

4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known as Coq2, catalyzes the prenylation of p-hydroxybenzoate with an all-trans polyprenyl group, an important step in ubiquinone (CoQ) biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260122 [Multi-domain]  Cd Length: 272  Bit Score: 352.15  E-value: 7.14e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 128 MRLDKPIGTWLLYLPCTWSIGLAAEPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANRPIAAGDISTF 207
Cdd:cd13959    1 MRLDKPIGTLLLLPPALWGLLLAAGGLPLPLLKLLLLFLLGAFLMRSAGCTINDIADRDIDAKVPRTKNRPLASGAISVK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 208 QSFVFLGGQLTLALGVLLCLNYYSIALGAGSLLLVITYPLMKRISYWPQLALGLTFNWGALLGWSAIKGSCDPsVCLPLY 287
Cdd:cd13959   81 EALLFLAVQLLLGLALLLQLNPLTILLSPIALLLVLIYPLMKRFTYWPQLVLGLAFGWGPLMGWAAVTGSLPL-PALLLY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 288 FSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFSVAMLGALSLVGVNSGQTAPYYAALGAVgAHLTHQ 367
Cdd:cd13959  160 LAVIFWTAGYDTIYAHQDREDDRKIGVKSTAVLFGDRTKLILALLLHLFVALLLLAGGLAGLGWPYYLGLGAA-AHLLWQ 238

                        250       260       270
                 ....*....|....*....|....*....|....
gi 260656052 368 IYTLDIHRPE-DCWNKFISNRTLGLIVFLGIVLG 400
Cdd:cd13959  239 EHRLDLPDPLrSCLAFFLSNGWVGLLLFAGLLLD 272
UbiA COG0382
4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate ...
 122-399 8.62e-75

4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate polyprenyltransferase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440151  Cd Length: 280  Bit Score: 234.74  E-value: 8.62e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 122 QPYLRLMRLDKPIGTWLLYLPCTWSIGLAAepGCFPDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANRPIAA 201
Cdd:COG0382    1 RAYLRLLRLDRPIGILLLLWPTLWALFLAA--GGLPDLLLLLLAVLGTVLMRSAGYVINDYFDREIDRINERKPNRPLAS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 202 GDISTFQSFVFLGGQLTLALGVLLCLNYYSIALGAGSLLLVITYPL-MKRISYWPQLALGLTFNWGALLGWSAIKGSCDP 280
Cdd:COG0382   79 GRISLREALLLAIVLLLLALALALLLNPLTFLLALAALALAWAYSLfLKRFTLLGNLVLGLLFGLGILMGFAAVTGSLPL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 281 SVcLPLYFSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSG-FSVAMLGALSLVGVNSGQTAPYYAALGA 359
Cdd:COG0382  159 SA-WLLALAAFLWTLAYDTIYDLEDREGDRKIGIKTLAILFGVRDALIIAGvLYALAVLLLLLLGLLAGLGLLYLLGLLA 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 260656052 360 VGAHL-THQIYTLD--IHRPEDCWNKFISNRTLGLIVFLGIVL 399
Cdd:COG0382  238 ALLLLyLSQLWLLRprKKDPARALKLFKLNMLLGLLLFLGIAL 280
UbiA pfam01040
UbiA prenyltransferase family;
147-383 4.10e-46

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 159.31  E-value: 4.10e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052  147 IGLAAEPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANRPIAAGDISTFQSFVFLGGQLTLALGVLLC 226
Cdd:pfam01040   7 AGLALAAGGVPDLLLLLLALLGTVLARAAANALNDYYDRDIDAIMPRTPNRPLPSGRISPREALIFALVLLALGLLLLLL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052  227 LNYYSIALGAGSLLLVITYPL-MKRISYWPQLALGLTFNWGALLGWSAIKGSCDPSVcLPLYFSGVMWTLIYDTIYAHQD 305
Cdd:pfam01040  87 LNPLTALLGLAALLLYVLYTLrLKRRTLLGQLVGGLAFGLPPLLGWAAVTGSLSPLA-LLLALALFLWTWAIALANDLRD 165

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 260656052  306 KRDDVLIGLKSTALRFGENTKPWLS-GFSVAMLGALSLVGVNSGQTAPYYAALGAVGAHLTHQIYTLDIHRPEDCWNKF 383
Cdd:pfam01040 166 REDDRKAGIKTLPVVLGRKAARILLaLLLAVALLLLLLLLLLLLGGLYLLLALLLAALALLYAARLLRLRDPKKDAKAF 244
ubiA PRK12873
4-hydroxybenzoate polyprenyltransferase;
121-403 1.13e-41

4-hydroxybenzoate polyprenyltransferase;


Pssm-ID: 171787 [Multi-domain]  Cd Length: 294  Bit Score: 149.04  E-value: 1.13e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 121 LQPYLRLMRLDKPIGTWLLYLPCTWSIGLAaePGCFPDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANRPIA 200
Cdd:PRK12873   7 LSPWFELLRWNKPTGRLILLIPAGWSLWLT--PSAPPSLLLLLLIILGGLAVSGAGCIANDLWDRRIDRKVERTKNRPLA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 201 AGDISTFQSFVFLGGQLTLALGVLLCL----NYYSIALGAGSLLLVITYPLMKRISYWPQLALGLTFNWGALLGWSAIKG 276
Cdd:PRK12873  85 RGKISLKTAYSLLIVLLLLSLFVVLSLpqpsRNLCLSLAFLALPPILIYPSAKRWFAYPQAILALCWGFAVLIPWAAAEG 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 277 SCDPSVclPLYFS---GVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFSVAMLGALSLVGVNSGQTAPY 353
Cdd:PRK12873 165 SLNGGW--PLLFCwlaTLLWTFGFDTVYAMADRRDDAKIGLNSSALSLGSNALKTVQICYFLTSIFLALAAFIAQVGFIF 242

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 260656052 354 YAAlgAVGAHLTHQIYTLDIHRPEDCWNKF---ISNRT-LGLIVFLGIVLGNLW 403
Cdd:PRK12873 243 WPF--WLIASIGMQRDILKLFPEKQSIKTIgnhFSNQViLGSLLLLGLILARGG 294
ubiA_other TIGR01475
putative 4-hydroxybenzoate polyprenyltransferase; A fairly deep split separates this ...
 124-403 3.69e-28

putative 4-hydroxybenzoate polyprenyltransferase; A fairly deep split separates this polyprenyltransferase subfamily from the set of mitochondrial and proteobacterial 4-hydroxybenzoate polyprenyltransferases, described in TIGR01474. Protoheme IX farnesyltransferase (heme O synthase) (TIGR01473) is more distantly related. Because no species appears to have both this protein and a member of TIGR01474, it is likely that this model represents 4-hydroxybenzoate polyprenyltransferase, a critical enzyme of ubiquinone biosynthesis, in the Archaea, Gram-positive bacteria, Aquifex aeolicus, the Chlamydias, etc. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273646  Cd Length: 282  Bit Score: 112.06  E-value: 3.69e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052  124 YLRLMRLDKPIgtwlLYLPCTWSIGLAAEPGcFPDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANRPIAAGD 203
Cdd:TIGR01475   5 ILELIKFEHTV----FALPFAYAGALLAAKG-LPGLKTLILILIAAVSARTAAMAFNRIIDRAIDARNPRTKNRPLVSGL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052  204 ISTFQSFVFLGGQLTLALGVLLCLNYYSIALGAGSLLLVITYPLMKRISYWPQLALGLTFNWGALLGWSAIKGSCDPSVC 283
Cdd:TIGR01475  80 ISKKEARTMIILSLALFLSASYFLNPLAFILSPLVLLVLIIYPYTKRFTFLCHYVLGSTYGLAPLAGWVAVIGTISFFLV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052  284 LPLYFSGV-MWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFS-VAMLGALSLVGVNSGQTAPYYAALGAVG 361
Cdd:TIGR01475 160 AWLLGIGVgFWIAGFDLIYAIQDYEFDRKNGLHSIPARFGIKAALKIASLShVITFILLLLVGFYVGNGYIALLALILIG 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 260656052  362 AHLTHQIYTLDIHRPEDCWNKFIS-NRTLGLIVFLGIVLGNLW 403
Cdd:TIGR01475 240 LILAYEHYIVDPGDQSKIQRAFFYaNGFLSITFLIGVIIDVLL 282
PT_UbiA cd13956
UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA ...
 129-400 7.53e-17

UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260119 [Multi-domain]  Cd Length: 271  Bit Score: 80.08  E-value: 7.53e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 129 RLDKPIGTWLLYLPCTWSIGLAAEPGCFPDWYMLSLFGtGAILMRGAGCTINDMWDQDYDKKvtRTANRPIAAGDISTFQ 208
Cdd:cd13956    2 RLMRPYTLLYVLAPALAGAALAGAFAGPLPALLLLALL-AVFLGAGAGYALNDYTDRELDAI--NKPDRPLPSGRLSPRQ 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 209 SFVFLGGQLTLALGVLLCLNYYSIALGAGSLLLVITYPLMKRISYWPQLA-LGLTFNWGALLGWSAIKGSCDPSVCLPLY 287
Cdd:cd13956   79 ALAFAAALLLVGLALALALGPLALLLLLAGLLLGLAYSLGLKRLKLGGWGvLGYATGLALLPGLGAVAAGGLVPLALLLA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 288 FSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLS-GFSVAMLGALSLVGVNSGQTAPYYAALGAVGAhLTH 366
Cdd:cd13956  159 LVFLLLGLGINLYNDLPDVEGDRAAGIRTLPVRLGPRRARRLAaGLLLAALILVVLLAVAGLLGPLALLALLAVAL-LAL 237

                        250       260       270
                 ....*....|....*....|....*....|....
gi 260656052 367 QIYTLDIHRPEDCWNKFISNRTLGLIVFLGIVLG 400
Cdd:cd13956  238 RARFARADRLPALPRGFLLLAVYRLLLFAALLLA 271
ubiA PRK12874
4-hydroxybenzoate polyprenyltransferase;
179-403 4.37e-14

4-hydroxybenzoate polyprenyltransferase;


Pssm-ID: 237242  Cd Length: 291  Bit Score: 72.35  E-value: 4.37e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 179 INDMWDQDYDKKVTRTANRPIAAGDISTFQSFVFLGGQLTLALGVLLCLNYYSIALGAGSLLLVITYPLMKRISYWPQLA 258
Cdd:PRK12874  66 FNRLVDRDIDKDNPRTANRPSVDGRISVKSMVLFIVLNALIFIGVSYFINPLAFKLSFPFLIVLGGYSYFKRFSSLAHLV 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 259 LGLTFNWGALLGWSAIKGSCDP-SVCLPLyfsGVM-WTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFS--V 334
Cdd:PRK12874 146 LGLSLGLAPIAGVVAVLGEIPLwSVFLAL---GVMfWVAGFDLLYSLQDMEFDKKRGLHSIPSKFGEKATLFISRLFhlL 222

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 335 AMLGALSLVGV-NSGQTAPYYAALGAVGAHLTHQIYTLDIHRPEDCWnkFISNRTLGLIVFLGIVLGNLW 403
Cdd:PRK12874 223 AVLFWLLFVWCaHLGLFAYLGVIVSALILLYEHYLVRKDFKKIDKAF--FTLNGYLGIVFFIFIVLDVLF 290
PT_UbiA_Cox10 cd13957
Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O ...
 128-280 5.68e-14

Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O synthase, heme A:farnesyltransferase, cytochrome c oxidase subunit X [Cox10]) converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of the heme B porphyrin ring with a hydroxyethyl farnesyl side group. It is localized at the mitochondrial inner membrane. Eukaryotic Cox10 is important for the maturation of the heme A prosthetic group of cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, that catalyzes the electron transfer from reduced cytochrome c to oxygen. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260120  Cd Length: 271  Bit Score: 71.70  E-value: 5.68e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 128 MRLDKPIGTWLLYLpcTWSIGLAAEPGCFPDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANRPIAAGDISTF 207
Cdd:cd13957    1 LELTKPRITLLVLL--TALAGYLLAPGGVPDLLLLLLTLLGTALVSASANALNQYIERDIDAKMKRTRNRPLPSGRISPK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 208 QSFVFLGGQLTLALGVL-LCLNYYSIALGAGSLLL-VITYPLMKRISYWpqlalgltFN--WGA-------LLGWSAIKG 276
Cdd:cd13957   79 HALIFGLVLGILGLALLaLFVNPLTALLGLLGIFLyVFVYTPLKKRTTP--------LNtvIGGiagaippLIGWAAATG 150


                 ....
gi 260656052 277 SCDP 280
Cdd:cd13957  151 SLDL 154
ubiA PRK12886
prenyltransferase; Reviewed
 158-364 1.38e-13

prenyltransferase; Reviewed


Pssm-ID: 237247  Cd Length: 291  Bit Score: 70.87  E-value: 1.38e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 158 DWYMLSLFGTgailmRGAGCTINDMWDQDYDKKVTRTANRPIAAGDISTFQSFVFLGGQLTLALGVLLCLNYYSIALGAG 237
Cdd:PRK12886  45 DWILMAMVGA-----RTAAMGFNRLIDAEIDARNPRTAGRAIPAGLISKGSAILFIVLSSLLMLFAAWFLNPLCLYLSPP 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 238 SLLLVITYPLMKRISYWPQLALGLTFNWGALLGWSAIKGSCDPSVCLpLYFSGVMWTLIYDTIYAHQDKRDDVLIGLKST 317
Cdd:PRK12886 120 ALFFLLLYSYCKRFTALAHVVLGFCLALAPLGAWIAIRGTIELPAIL-LGLAVLFWVAGFDILYALQDLEFDRKEGLHSI 198

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 260656052 318 ALRFGENTKPWLS-GFSVAMLGALSLVGVNSGQTAPYYAALGAVGAHL 364
Cdd:PRK12886 199 PAKLGVNGSLWIArVFHLLMIGFLFALGISAGLGPWFLAGLAVTGILL 246
ubiA PRK13106
prenyltransferase; Reviewed
 124-399 6.87e-13

prenyltransferase; Reviewed


Pssm-ID: 237283  Cd Length: 300  Bit Score: 68.99  E-value: 6.87e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 124 YLRLMRLDKPigtwLLYLPCTWSIGLAAEPGcFPDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANRPIAAGD 203
Cdd:PRK13106  18 ILRFLRIEQT----FFSLPMAYLGAFVAIKG-IPPISTLILIFLALFFLRTAGMTNDNLADLEIDAKNPRTKNRPLVTGA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 204 ISTFQSFVFLGGQLTLALGVLLCLNYYSIALGAGSLLLVITYPLMKRISYWPQLALGLTFNWGALLGWSAIKGSCDPSVC 283
Cdd:PRK13106  93 IKISEAKALITAGLILFFASAYLVNRWALLLSPIVALIAMSYPYMKRYTAFANYHLASIQGLAVFSGAVAVLGLYANSLI 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 284 LPLY-------FSGVMWTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPwLSGFSVAMLGALSLVGVNSGQTAPYYAA 356
Cdd:PRK13106 173 QVLLrvpwlfvIGTILWAAGFDLYNHIPDAEFDREMGLHSFAVVLGKWALT-FAGLNQLFSVVLDLLGDLYYGLGPIAIA 251

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 260656052 357 LGAVGAHLTHQIYTLdIHRPEDCWNKFISNRTLGLIVFLGIVL 399
Cdd:PRK13106 252 ATILHGLIMAYAYYL-ASKKGDFGRAFYYNIYSSIVLGLGIII 293
PRK04375 PRK04375
protoheme IX farnesyltransferase; Provisional
 149-280 5.48e-12

protoheme IX farnesyltransferase; Provisional


Pssm-ID: 235293  Cd Length: 296  Bit Score: 65.93  E-value: 5.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 149 LAAEPGCFPDWYML-SLFGTGaiLMRGAGCTINDMWDQDYDKKVTRTANRPIAAGDISTFQSFVFLGGQLTLALGVLLCL 227
Cdd:PRK04375  34 LLAPPGVPPLLLLLlTLLGIA--LVAGAAGALNNYIDRDIDAKMERTKNRPLVTGRISPREALIFGLVLGVLGFLLLGLF 111

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 260656052 228 -NYYSIALGAGSLLL-VITYPL-MKRISywPQ------LAlgltfnwGA---LLGWSAIKGSCDP 280
Cdd:PRK04375 112 vNPLAAWLTLAGIFFyVVVYTLwLKRRT--PQniviggAA-------GAmppLIGWAAVTGSLSW 167
ubiA PRK12876
prenyltransferase; Reviewed
 139-323 9.76e-12

prenyltransferase; Reviewed


Pssm-ID: 237244  Cd Length: 300  Bit Score: 65.54  E-value: 9.76e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 139 LYLPCTwSIGLAAEPGcfpdWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANRPIAAGDISTfqSFVFLGGQLT 218
Cdd:PRK12876  31 LSLPEI-SFSLFSLGG----IKTISLGGSAFFCARTVGIIVNQIIDCAIDKKNPRTSSRVLPAKLLSI--NFSMLLLTLC 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 219 LALGVLLC--LNYYSIALGAGSLLLVITYPLMKRISYWPQLALGLTFNWGALLGWSAIKGScdpSVCLPLYFSGVMWTLI 296
Cdd:PRK12876 104 SFLFLSLCwlLNPLCFSLAVLSTLLMIIYPYTKRVTFLCHWILGLVYYLAILMNFFAIIET---PLSFSLFCMASLWGIS 180

                        170       180       190
                 ....*....|....*....|....*....|....
gi 260656052 297 Y-------DTIYAHQDKRDDVLIGLKSTALRFGE 323
Cdd:PRK12876 181 FgmiiaanDIIYAIQDLEFDRKEGLFSIPARFGE 214
ubiA PRK12888
4-hydroxybenzoate octaprenyltransferase;
157-378 4.91e-10

4-hydroxybenzoate octaprenyltransferase;


Pssm-ID: 183814  Cd Length: 284  Bit Score: 60.12  E-value: 4.91e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 157 PDWYMLSLFGTGAILMRGAGCTINDMWDQDYDKKVTRTANRPIAAGDISTFQSFVFLGGQLTLALGVLLCLNYYSIALGA 236
Cdd:PRK12888  36 VHWADLLLVTVAMVGARTFAMAANRIIDREIDARNPRTAGRELVTGAVSVRTAWTGALVALAVFLGAAALLNPLCLALAP 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 237 GSLLLVITYPLMKRISYWPQLALGLTFNWGALLGWSAIKGSCD-PSVCLPLYFSgvMWTLIYDTIYAHQDKRDDVLIGLK 315
Cdd:PRK12888 116 LAVAPLVVYPYAKRFTNFPHAILGLAQAVGPVGAWIAVTGTWSwPAVLLGLAVG--LWIGGFDLIYACQDAEVDRRIGVR 193

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 260656052 316 STALRFGENTKPWLSGFS-VAMLGALSLVGVNSGQTAPYYAALGAVGAHLthqIYTLDIHRPED 378
Cdd:PRK12888 194 SVPARFGVRAALWASRVAhVVTFALFVWFGLAVGFGALWWIGLAITAGAF---AYEHAIVSPTD 254
ubiA PRK12895
prenyltransferase; Reviewed
 149-400 7.11e-07

prenyltransferase; Reviewed


Pssm-ID: 237251  Cd Length: 286  Bit Score: 50.58  E-value: 7.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 149 LAAEPGCFPDWYMLSLFGtgAILMRGAGCTINDMWDQDYDKKVTRTANRPIAAGDISTFQSFVFLGGQLTLALGVLLCLN 228
Cdd:PRK12895  28 IAAGHYIHPIKILLILIA--AVSARTSAMSINRIEGLRYDMINPRKKDWALVSGRIKMREAIAFTIIFIAIFEICTFLLN 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 229 YYSIALGAGSLLLVITYPLMKRISYWPQLALGLTFNWGALLGWSAIKGS--CDPSVCLpLYFSGVMWTLIYDTIYAHQDK 306
Cdd:PRK12895 106 RLVFILSPIVIFLFIIDPFLKRYTAWRHIYMGSIIGLGVLAGYLAVIPAfpYNLLIYI-IFISSSLWIAGFDIIYVIPDI 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 307 RDDVLIGLKSTALRFGENTKPWLSGF---SVAMLGALSLVGVNsgqTAPYYAALGAVGAHLTHQIYTLDIHRPEDCWNKF 383
Cdd:PRK12895 185 EYDKINGLKTIMNTYGIKNGLYISDIfhiSSLILFWISGIYIR---TLWYLAALIIIYTLVIYQHLIIDPRNPINKRMSF 261

                        250
                 ....*....|....*...
gi 260656052 384 I-SNRTLGLIVFLGIVLG 400
Cdd:PRK12895 262 FnANSFIGFVFLIGIILS 279
PT_UbiA_2 cd13963
UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of ...
 179-274 6.47e-04

UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways. The function of this subgroup is unknown.


Pssm-ID: 260126  Cd Length: 278  Bit Score: 41.31  E-value: 6.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 179 INDMWDQDYDKKVTRTANRPIAAGDISTFQSFVFLGGQLTLALGVLLCLNYYSIALGAGSLLLVITYPL-MKRISYWPQL 257
Cdd:cd13963   52 LNDLLDLEADRLHPTKRNRPIASGRLSIPAALALAVVLLLAGLALALLLSPAFLLVLLAYLVLNLAYSLkLKRIPLLDVF 131

                         90
                 ....*....|....*..
gi 260656052 258 ALGLTFNWGALLGWSAI 274
Cdd:cd13963  132 VIAAGFVLRVLAGAVAI 148
PT_UbiA_DGGGPS cd13961
Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Digeranylgeranylglyceryl phosphate ...
 123-360 9.35e-04

Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Digeranylgeranylglyceryl phosphate synthase (DGGGPS) transfers a geranylgeranyl group from geranylgeranyl diphosphate to (S)-3-O-geranylgeranylglyceryl phosphate to form (S)-2,3-di-O-geranylgeranylglyceryl phosphate, as part of the isoprenoid ether lipid biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260124  Cd Length: 270  Bit Score: 40.95  E-value: 9.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 123 PYLRLMRLDKP----IGTWLLYlpctwsIGLAAEPGCFPDWYMLSLFGTGAILMrGAGCTINDMWDQDYDKkVTRTaNRP 198
Cdd:cd13961    1 AYLELIRPPNLlmaaLAQYLGA------LFALGPLLSLNDLELLLLFLSVFLIA-AAGYIINDYFDVEIDR-INKP-DRP 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 199 IAAGDIStfQSFVFLGGQLTLALGVLL--CLNYYSIALGAGSLLLVITYP-LMKRISYWPQLA----LGLTFNWGALLGW 271
Cdd:cd13961   72 IPSGRIS--RREALILSILLNALGLILafLLSPLALLIALLNSLLLWLYShKLKRTPLIGNLLvallTGLPFLFGGLAAG 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 272 SAIKGSCDPSVCLPLYfsgvmwTLIYDTIYAHQDKRDDVLIGLKSTALRFGENTKPWLSGFSVAMLGALSLVGVNSGQTA 351
Cdd:cd13961  150 NLLLIILLLALFAFLI------TLGREIVKDIEDVEGDRAEGARTLPIVYGIKKAKKIAALLLLLAILLSPLPYLLGGLG 223


                 ....*....
gi 260656052 352 PYYAALGAV 360
Cdd:cd13961  224 ILYLILIII 232
PLN02776 PLN02776
prenyltransferase
 178-288 9.86e-04

prenyltransferase


Pssm-ID: 215415  Cd Length: 341  Bit Score: 40.88  E-value: 9.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 260656052 178 TINDMWDQDYDKKVTRTANRPIAAGDIS-----TFQSFVFLGGQLTLALGVllclNYYSIALGAGSLLL-VITYPLMKRI 251
Cdd:PLN02776  47 TLNQVFEVKNDSKMKRTMRRPLPSGRISvphavAWAVVVGAAGVALLAYKT----NMLTAGLGAGNILLyAFVYTPLKQI 122

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 260656052 252 SYWPqlalgltfNW-GA-------LLGWSAIKGSCDP-SVCLP--LYF 288
Cdd:PLN02776 123 HPAN--------TWvGAvvgaippLMGWAAASGQLDAgAMVLAaaLYF 162
ubiA PRK12882
prenyltransferase; Reviewed
 170-245 8.43e-03

prenyltransferase; Reviewed


Pssm-ID: 183811  Cd Length: 276  Bit Score: 38.03  E-value: 8.43e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 260656052 170 ILMRGAGCTINDMWDQDYDkKVTRtANRPIAAGDISTFQSFVFLGGQLTLALGVLLCLNYYSIALGAGSLLLVITY 245
Cdd:PRK12882  48 FLATGAGNAINDYFDREID-RINR-PDRPIPSGAVSPRGALAFSILLFAAGVALAFLLPPLCLAIALFNSLLLVLY 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH