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Conserved domains on  [gi|7657220|ref|NP_056605|]
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ICOS ligand precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_B7-H2 cd20935
Immunoglobulin Variable (IgV) domain of B7-H2 (B7 homolog 2); The members here are composed of ...
 48-161 5.74e-67

Immunoglobulin Variable (IgV) domain of B7-H2 (B7 homolog 2); The members here are composed of the immunoglobulin variable (IgV) domain of B7-H2 (B7 homolog 2 also known as ICOSL (inducible T cell costimulator ligand) or CD275). B7-H2 is a ligand for the T-cell-specific cell surface receptor ICOS and acts as a costimulatory signal for T-cell proliferation and cytokine secretion. The interaction of ICOS with ICOSL (B7-H2) regulates T cell activation and expansion, is involved in T cell dependent B cell activation, and T-helper cell differentiation. It is a member of the B7 family of immune regulatory proteins and shares homology with other B7 ligands, such as B7-1, B7-2, B7-H1 (PD-L1), PD-L2, and B7-H3. The extracellular domains of B7 proteins contain two Ig-like domains and all members have short cytoplasmic domains. These ligands are typically expressed on antigen presenting cells (such as macrophages, B cells and dendritic cells) and have the ability to regulate T-cell proliferation and function. Tumor cells are also capable of expressing the B7 family members in order to evade immune surveillance.


:

Pssm-ID: 409529  Cd Length: 113  Bit Score: 205.48  E-value: 5.74e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657220   48 TEVGAMVGSNVVLSCIDPHRRHFNLSGLYVYWQIENPEVSVTYYLPYKSPGINVDSSYKNRGHLSLDSMKQGNFSLYLKN 127
Cdd:cd20935   1 KEVRAMVGSDVELSCICPEGSRFDLNDLYVYWQISESETVVTYHLPQNSSLENVDSHYRNRALLSLDSMKQGDFSLRLFN 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 7657220  128 VTPQDTQEFTCRVFMNTaTELVKILEEVVRLRVA 161
Cdd:cd20935  81 VTPQDEQKFHCLVFSQS-LELQKVLEVVVTLHVA 113
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 166-253 1.27e-07

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member pfam08205:

Pssm-ID: 472250  Cd Length: 89  Bit Score: 48.57  E-value: 1.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657220    166 TPVISTSDSSNPGQERTYTCMSKNGYPEPNLYWIntTDNSLIDTALQNNTVYLNKlGLYDVISTLRLPwTSRGD----VL 241
Cdd:pfam08205   2 TIEPPASLLEGEGPEVVATCSSAGGKPAPRITWY--LDGKPLEAAETSSEQDPES-GLVTVTSELKLV-PSRSDhgqsLT 77

                          90
                  ....*....|..
gi 7657220    242 CCVENVALHQNI 253
Cdd:pfam08205  78 CQVSYGALRGSI 89
 
Name Accession Description Interval E-value
IgV_B7-H2 cd20935
Immunoglobulin Variable (IgV) domain of B7-H2 (B7 homolog 2); The members here are composed of ...
 48-161 5.74e-67

Immunoglobulin Variable (IgV) domain of B7-H2 (B7 homolog 2); The members here are composed of the immunoglobulin variable (IgV) domain of B7-H2 (B7 homolog 2 also known as ICOSL (inducible T cell costimulator ligand) or CD275). B7-H2 is a ligand for the T-cell-specific cell surface receptor ICOS and acts as a costimulatory signal for T-cell proliferation and cytokine secretion. The interaction of ICOS with ICOSL (B7-H2) regulates T cell activation and expansion, is involved in T cell dependent B cell activation, and T-helper cell differentiation. It is a member of the B7 family of immune regulatory proteins and shares homology with other B7 ligands, such as B7-1, B7-2, B7-H1 (PD-L1), PD-L2, and B7-H3. The extracellular domains of B7 proteins contain two Ig-like domains and all members have short cytoplasmic domains. These ligands are typically expressed on antigen presenting cells (such as macrophages, B cells and dendritic cells) and have the ability to regulate T-cell proliferation and function. Tumor cells are also capable of expressing the B7 family members in order to evade immune surveillance.


Pssm-ID: 409529  Cd Length: 113  Bit Score: 205.48  E-value: 5.74e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657220   48 TEVGAMVGSNVVLSCIDPHRRHFNLSGLYVYWQIENPEVSVTYYLPYKSPGINVDSSYKNRGHLSLDSMKQGNFSLYLKN 127
Cdd:cd20935   1 KEVRAMVGSDVELSCICPEGSRFDLNDLYVYWQISESETVVTYHLPQNSSLENVDSHYRNRALLSLDSMKQGDFSLRLFN 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 7657220  128 VTPQDTQEFTCRVFMNTaTELVKILEEVVRLRVA 161
Cdd:cd20935  81 VTPQDEQKFHCLVFSQS-LELQKVLEVVVTLHVA 113
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 166-253 1.27e-07

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 48.57  E-value: 1.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657220    166 TPVISTSDSSNPGQERTYTCMSKNGYPEPNLYWIntTDNSLIDTALQNNTVYLNKlGLYDVISTLRLPwTSRGD----VL 241
Cdd:pfam08205   2 TIEPPASLLEGEGPEVVATCSSAGGKPAPRITWY--LDGKPLEAAETSSEQDPES-GLVTVTSELKLV-PSRSDhgqsLT 77

                          90
                  ....*....|..
gi 7657220    242 CCVENVALHQNI 253
Cdd:pfam08205  78 CQVSYGALRGSI 89
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 47-160 2.66e-05

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 42.83  E-value: 2.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657220     47 ETEVGAMVGSNVVLSCidphrrHFNLS----GLYVYW----QIENPEVSVTYYLPYKSPGInvdssYKNRGHLSLDSMKq 118
Cdd:pfam07686   3 PREVTVALGGSVTLPC------TYSSSmseaSTSVYWyrqpPGKGPTFLIAYYSNGSEEGV-----KKGRFSGRGDPSN- 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 7657220    119 GNFSLYLKNVTPQDTQEFTCRVFMNTATelvkILEEVVRLRV 160
Cdd:pfam07686  71 GDGSLTIQNLTLSDSGTYTCAVIPSGEG----VFGKGTRLTV 108
IGv smart00406
Immunoglobulin V-Type;
57-138 3.78e-05

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 41.60  E-value: 3.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657220      57 NVVLSCidpHRRHFNLSGLYVYWQIENPEVSVTYYLPYKSPGINVD-SSYKNRGHLSLDSMKqGNFSLYLKNVTPQDTQE 135
Cdd:smart00406   1 SVTLSC---KFSGSTFSSYYVSWVRQPPGKGLEWLGYIGSNGSSYYqESYKGRFTISKDTSK-NDVSLTISNLRVEDTGT 76


                   ...
gi 7657220     136 FTC 138
Cdd:smart00406  77 YYC 79
IgC1 cd00098
Immunoglobulin Constant-1 (C1)-set domain; The members here are composed of C1-set domains, ...
 168-254 1.44e-04

Immunoglobulin Constant-1 (C1)-set domain; The members here are composed of C1-set domains, classical Ig-like domains resembling the antibody constant domain. Members of the IgC1 family are components of immunoglobulin, T-cell receptors, CD1 cell surface glycoproteins, secretory glycoproteins A/C, and major histocompatibility complex (MHC) class I/II molecules. In immunoglobulins, each chain is composed of one variable domain (IgV) and one or more IgC domains. These names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. The IgV domain is responsible for antigen binding, while the IgC domain is involved in oligomerization and molecular interactions. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other strands by G, F, C, and C'.


Pssm-ID: 409354  Cd Length: 95  Bit Score: 40.14  E-value: 1.44e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657220  168 VISTSDSSNPGQERTYTCMSKNGYPEP-NLYWinTTDNSLIDTALQNNTVYLNKLGLYDVISTLRLP---WTSRGDVLCC 243
Cdd:cd00098   4 LLPPSPEEKGGGKVTLVCLVSGFYPKDiTVTW--LKNGVPLTSGVSTSSPVEPNDGTYSVTSSLTVPpsdWDEGATYTCV 81

                        90
                ....*....|.
gi 7657220  244 VENVALHQNIT 254
Cdd:cd00098  82 VTHESLKSPLS 92
 
Name Accession Description Interval E-value
IgV_B7-H2 cd20935
Immunoglobulin Variable (IgV) domain of B7-H2 (B7 homolog 2); The members here are composed of ...
 48-161 5.74e-67

Immunoglobulin Variable (IgV) domain of B7-H2 (B7 homolog 2); The members here are composed of the immunoglobulin variable (IgV) domain of B7-H2 (B7 homolog 2 also known as ICOSL (inducible T cell costimulator ligand) or CD275). B7-H2 is a ligand for the T-cell-specific cell surface receptor ICOS and acts as a costimulatory signal for T-cell proliferation and cytokine secretion. The interaction of ICOS with ICOSL (B7-H2) regulates T cell activation and expansion, is involved in T cell dependent B cell activation, and T-helper cell differentiation. It is a member of the B7 family of immune regulatory proteins and shares homology with other B7 ligands, such as B7-1, B7-2, B7-H1 (PD-L1), PD-L2, and B7-H3. The extracellular domains of B7 proteins contain two Ig-like domains and all members have short cytoplasmic domains. These ligands are typically expressed on antigen presenting cells (such as macrophages, B cells and dendritic cells) and have the ability to regulate T-cell proliferation and function. Tumor cells are also capable of expressing the B7 family members in order to evade immune surveillance.


Pssm-ID: 409529  Cd Length: 113  Bit Score: 205.48  E-value: 5.74e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657220   48 TEVGAMVGSNVVLSCIDPHRRHFNLSGLYVYWQIENPEVSVTYYLPYKSPGINVDSSYKNRGHLSLDSMKQGNFSLYLKN 127
Cdd:cd20935   1 KEVRAMVGSDVELSCICPEGSRFDLNDLYVYWQISESETVVTYHLPQNSSLENVDSHYRNRALLSLDSMKQGDFSLRLFN 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 7657220  128 VTPQDTQEFTCRVFMNTaTELVKILEEVVRLRVA 161
Cdd:cd20935  81 VTPQDEQKFHCLVFSQS-LELQKVLEVVVTLHVA 113
IgV_B7-H3 cd20934
Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint ...
 47-164 5.43e-10

Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint molecules; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H3 also known as CD276), a member of the B7 family of immune checkpoint molecules. B7-H3 is an important immune checkpoint member of the B7 family and shares homology with other B7 ligands such as programmed death ligand 1 (PD-L1). The B7 family molecules interact with CD28 on T-cells to provide co-stimulatory signals that regulate T-cell activation and T-helper cell differentiation. Although B7-H3 has been shown to have both co-stimulatory and co-inhibitory effects on T-cell responses, the most current studies describe B7-H3 as a T cell inhibitor that promotes tumor aggressiveness and proliferation. Moreover, B7-H3 is highly overexpressed on a wide range of human solid cancers and promotes tumor growth, metastasis, and drug resistance. Thus, B7-H3 expression in tumors often correlates with both negative prognosis and poor clinical outcome in cancer patients. B7-H3 protein contains a predicted signal peptide, V- and C-like Ig domains (IgV and IgC), a transmembrane region, and an intracellular tail.


Pssm-ID: 409528  Cd Length: 115  Bit Score: 56.07  E-value: 5.43e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657220   47 ETEVGAMVGSNVVLSCIDPHRRHFNLSGLYVYWQIENPEVSVTYYLPYKSPGINVDSSYKNRGHLSLDSMKQGNFSLYLK 126
Cdd:cd20934   4 EDPVVALVGTDATLRCSFSPEPGFSLAQLSVFWQLTDTKQLVHSFTESQDQGRDQGSAYANRTALFPDLLAQGNASLRLQ 83

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 7657220  127 NVTPQDTQEFTCRVFMNTATelvkilEEVVRLRVAANF 164
Cdd:cd20934  84 RVRVADEGSYTCFVSVQDFG------SAAVSLQVAAPF 115
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 166-253 1.27e-07

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 48.57  E-value: 1.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657220    166 TPVISTSDSSNPGQERTYTCMSKNGYPEPNLYWIntTDNSLIDTALQNNTVYLNKlGLYDVISTLRLPwTSRGD----VL 241
Cdd:pfam08205   2 TIEPPASLLEGEGPEVVATCSSAGGKPAPRITWY--LDGKPLEAAETSSEQDPES-GLVTVTSELKLV-PSRSDhgqsLT 77

                          90
                  ....*....|..
gi 7657220    242 CCVENVALHQNI 253
Cdd:pfam08205  78 CQVSYGALRGSI 89
IgV_PDl1 cd20947
Immunoglobulin Variable (IgV) domain of Programmed death ligand 1 (PD-L1); The members here ...
 55-140 1.49e-07

Immunoglobulin Variable (IgV) domain of Programmed death ligand 1 (PD-L1); The members here are composed of the immunoglobulin variable (IgV) domain of Programmed death ligand 1 (PD-L1; also known as Cluster of Differentiation 274 (CD274)). PD-L1 is a cell-surface ligand that competes with PD-L2 for binding to the immunosuppressive receptor programmed death-1 (PD-1). PD-1 is a member of the B7 family that plays an important role in negatively regulating immune responses upon interaction with its two ligands, PD-L1 or PD-L2. Like PD-L2, PD-L1 interacts with PD-1 and suppresses T cell proliferation and cytokine production. The PD-1 receptor is expressed on the surface of activated T cells, while PD-L1 is expressed on cancer cells. When PD-1 and PD-L1 bind together, they form a molecular shield protecting tumor cells from being destroyed by the immune system. Thus, inhibiting the binding of PD-L1 to PD-1 with an antibody leads to killing of tumor cells by T cells. PD-1 inhibitors (such as Pembrolizumab, Nivolumab, and Cemiplimab) and PD-L1 inhibitors (such as Atezolizumab, Avelumab, and Durvalumab ) are an emerging class of immunotherapy that stimulate lymphocytes against tumor cells.


Pssm-ID: 409539  Cd Length: 110  Bit Score: 49.16  E-value: 1.49e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657220   55 GSNVVLSCIDPHRRHFNLSGLYVYWQIENPEVsVTYYLPYKSPGINvDSSYKNRGHLSLDSMKQGNFSLYLKNVTPQDTQ 134
Cdd:cd20947  13 GSNMTIECKFPVEKQLDLAALIVYWEMEDKNI-IQFVHGEEDLKVQ-HSSYRQRARLLKDQLSLGNAALQITDVKLQDAG 90


                ....*.
gi 7657220  135 EFTCRV 140
Cdd:cd20947  91 VYRCMI 96
IgV_CD86 cd16087
Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 86; The members here ...
 49-160 1.28e-05

Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 86; The members here are composed of the immunoglobulin variable region (IgV) in the Cluster of Differentiation (CD) 86). Glycoproteins B7-1 (also known as cluster of differentiation (CD) 80) and B7-2 (also known as CD86) are expressed on antigen-presenting cells and deliver the co-stimulatory signal through CD28 and CTLA-4 (also known as CD152) on T cells. signaling through CD28 augments the T-cell response, whereas CTLA-4 signaling attenuates it. The CTLA-4 and B7-2 monomers are both two-layer beta-sandwiches that display the chain topology characteristic of the immunoglobulin variable (V-type) domains present in antigen receptors. The front and back sheets of B7-2 are composed of AGFCC'C" and BED strands, respectively. Members of the IgV family are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond.


Pssm-ID: 409508  Cd Length: 108  Bit Score: 43.47  E-value: 1.28e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657220   49 EVGAMVGSNVVLSCIDPHRRHFNLSGLYVYWQIENPEVSVTYYLPYKSPGiNVDSSYKNRghlslDSMKQGNFSLYLKNV 128
Cdd:cd16087   2 KIQAYFNETAYLPCQFKNPQNISLSELVVFWQDQKKLVLYELYLGKEKLD-NVNSKYIGR-----TSFDQENWTLQLHNV 75

                        90       100       110
                ....*....|....*....|....*....|..
gi 7657220  129 TPQDTQEFTCRVFMNTATELVKILEEVVRLRV 160
Cdd:cd16087  76 QIKDQGTYQCFIHHKSPKGLVLIHQMSSELSV 107
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 47-160 2.66e-05

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 42.83  E-value: 2.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657220     47 ETEVGAMVGSNVVLSCidphrrHFNLS----GLYVYW----QIENPEVSVTYYLPYKSPGInvdssYKNRGHLSLDSMKq 118
Cdd:pfam07686   3 PREVTVALGGSVTLPC------TYSSSmseaSTSVYWyrqpPGKGPTFLIAYYSNGSEEGV-----KKGRFSGRGDPSN- 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 7657220    119 GNFSLYLKNVTPQDTQEFTCRVFMNTATelvkILEEVVRLRV 160
Cdd:pfam07686  71 GDGSLTIQNLTLSDSGTYTCAVIPSGEG----VFGKGTRLTV 108
IGv smart00406
Immunoglobulin V-Type;
57-138 3.78e-05

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 41.60  E-value: 3.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657220      57 NVVLSCidpHRRHFNLSGLYVYWQIENPEVSVTYYLPYKSPGINVD-SSYKNRGHLSLDSMKqGNFSLYLKNVTPQDTQE 135
Cdd:smart00406   1 SVTLSC---KFSGSTFSSYYVSWVRQPPGKGLEWLGYIGSNGSSYYqESYKGRFTISKDTSK-NDVSLTISNLRVEDTGT 76


                   ...
gi 7657220     136 FTC 138
Cdd:smart00406  77 YYC 79
IgV_HHLA2 cd16091
Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are ...
 44-140 1.34e-04

Immunoglobulin Variable (IgV) domain in HERV-H LTR-associating 2 (HHLA2); The members here are composed of the immunoglobulin variable (IgV) region in HERV-H LTR-associating 2 (HHLA2; also known as B7-H7/B7 homolog 7). HHLA2 is a member of the B7 family of immune regulatory proteins. Mature human HHLA2 consists of an extracellular domain (ECD) with three immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic domain. HHLA2 is widely expressed in human cancers including non-small cell lung carcinoma (NSCLS), triple negative breast cancer (TNBC), and melanoma, but has limited expression on normal tissues. Interestingly, unlike other members of B7 family, HHLA2 is not expressed in mice or rats. HHLA2 functions as a T cell coinhibitory molecules as it inhibits the proliferation of activated CD4(+) and CD8(+) T cells and their cytokine production. Furthermore, HHLA2 is constitutively expressed on the surface of human monocytes and is induced on B cells after stimulation, however it is not inducible on T cells.


Pssm-ID: 409512  Cd Length: 107  Bit Score: 40.45  E-value: 1.34e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657220   44 ASAETEVGAMVGSNVVLSC-IDPHRRHFnlsglyVYWQIENPEVSVTYYLPYKSPGINVDSSYKNRGHLSLDSMKQGNFS 122
Cdd:cd16091   1 AVSEVIVVCLLSEDCILPCsFTPGSEVV------IHWYKQDSDIKVHSYYYGKDQLESQDQRYRNRTSLFKDQISNGNAS 74

                        90
                ....*....|....*...
gi 7657220  123 LYLKNVTPQDTQEFTCRV 140
Cdd:cd16091  75 LLLRRVQLQDEGRYKCYT 92
IgC1 cd00098
Immunoglobulin Constant-1 (C1)-set domain; The members here are composed of C1-set domains, ...
 168-254 1.44e-04

Immunoglobulin Constant-1 (C1)-set domain; The members here are composed of C1-set domains, classical Ig-like domains resembling the antibody constant domain. Members of the IgC1 family are components of immunoglobulin, T-cell receptors, CD1 cell surface glycoproteins, secretory glycoproteins A/C, and major histocompatibility complex (MHC) class I/II molecules. In immunoglobulins, each chain is composed of one variable domain (IgV) and one or more IgC domains. These names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. The IgV domain is responsible for antigen binding, while the IgC domain is involved in oligomerization and molecular interactions. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other strands by G, F, C, and C'.


Pssm-ID: 409354  Cd Length: 95  Bit Score: 40.14  E-value: 1.44e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657220  168 VISTSDSSNPGQERTYTCMSKNGYPEP-NLYWinTTDNSLIDTALQNNTVYLNKLGLYDVISTLRLP---WTSRGDVLCC 243
Cdd:cd00098   4 LLPPSPEEKGGGKVTLVCLVSGFYPKDiTVTW--LKNGVPLTSGVSTSSPVEPNDGTYSVTSSLTVPpsdWDEGATYTCV 81

                        90
                ....*....|.
gi 7657220  244 VENVALHQNIT 254
Cdd:cd00098  82 VTHESLKSPLS 92
IgV_B7-H4 cd20984
Immunoglobulin Variable (IgV) domain of B7-H4; The members here are composed of the ...
 52-140 3.39e-04

Immunoglobulin Variable (IgV) domain of B7-H4; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H4 (also known as B7-S1, B7x, or Vtcn1). B7-H4 is one of the B7 family of immune-regulatory ligands that act as negative regulators of T cell function; it contains one IgV domain and one IgC domain. The B7-family consists of structurally related cell-surface protein ligands, which bind to receptors on lymphocytes that regulate immune responses. The binding of B7-H4 to unidentified receptors results in the inhibition of TCR-mediated T cell proliferation, cell-cycle progression and IL-2 production. As a co-inhibitory molecule, B7-H4 is widely expressed in tumor tissues and its expression is significantly associated with poor prognosis in human cancers such as glioma, pancreatic cancer, oral squamous cell carcinoma, renal cell carcinoma, and lung cancer.


Pssm-ID: 409576  Cd Length: 110  Bit Score: 39.50  E-value: 3.39e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657220   52 AMVGSNVVLSCI---DPhrrhfNLSGLYVYWQIENPEVSVTYYLPYKSPGINVDSSYKNRGHLSLDSMKQGNFSLYLKNV 128
Cdd:cd20984   9 GNIGEDGILSCTftpDI-----KLSDIVIQWLKEGDSGLVHEFKEGKDELSRQSPMFRGRTSLFADQVHVGNASLRLKNV 83

                        90
                ....*....|..
gi 7657220  129 TPQDTQEFTCRV 140
Cdd:cd20984  84 QLTDAGTYLCII 95
IgV_1_Nectin-3_like cd05887
First immunoglobulin variable (IgV) domain of nectin-3 (also known as poliovirus receptor ...
 47-140 3.03e-03

First immunoglobulin variable (IgV) domain of nectin-3 (also known as poliovirus receptor related protein 3), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3 (PVRL3) or cluster of differentiation (CD) 113). Nectin-3 belongs to the nectin family comprised of four transmembrane glycoproteins (nectins-1 through -4). Nectins are synaptic cell adhesion molecules (CAMs) which participate in adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. For example, during spermatid development, the nectin-3,-2 trans-interaction is required for the formation of Sertoli cell-spermatid junctions in testis, and during morphogenesis of the ciliary body, the nectin-3,-1 trans-interaction is important for apex-apex adhesion between the pigment and non-pigment layers of the ciliary epithelia. Nectins also heterophilically trans-interact with other CAMs such as nectin-like molecules (Necls); nectin-3 for example, trans-interacts with Necl-5, regulating cell movement and proliferation. Other proteins with which nectin-3 interacts include the actin filament-binding protein, afadin, integrin alpha-beta3, Par-3, and PDGF receptor; its interaction with PDGF receptor regulates the latter's signaling for anti-apoptosis.


Pssm-ID: 409470  Cd Length: 110  Bit Score: 36.84  E-value: 3.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657220   47 ETEVGAMVGSNVVLSCidphRRHFNLSGLYVYWQIENPEVSVTYYLPYKSPGINVDSSYKNRghLSLDSMKQGNFSLYLK 126
Cdd:cd05887   6 EPHVTAVWGKNVSLKC----LIEVNETITQISWEKIHGKSSQTVAVHHPQYGISIQGEYQGR--VSFKNYSLNDATITLH 79

                        90
                ....*....|....
gi 7657220  127 NVTPQDTQEFTCRV 140
Cdd:cd05887  80 NVGFSDSGKYICKA 93
IgV_1_JAM1-like cd20946
First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of ...
 43-160 5.29e-03

First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of the V-set of IgSF domains; The members here are composed of the first Ig-like domain of Junctional Adhesion Molecule-1 (JAM1)and similar domains. JAM1 is an immunoglobulin superfamily (IgSF) protein with two Ig-like domains in its extracellular region; it plays a role in the formation of endothelial and epithelial tight junction and acts as a receptor for mammalian reovirus sigma-1. The IgSF is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The first Ig-like domain of JAM1 is a member of the V-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C'-C" in the other.


Pssm-ID: 409538  Cd Length: 102  Bit Score: 35.98  E-value: 5.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657220   43 AASAETEVGAMVGSNVVLSCIDPHRRhfnlSGLYVYWQIENPEVSVTYYLPYKSPGinvdsSYKNRGHLSldsmkqgNFS 122
Cdd:cd20946   2 VPSSQQVVTVVENQEVILSCKTPKKT----SSPRVEWKKLQRDVTFVVFQNNKIQG-----DYKGRAEIL-------GTN 65

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 7657220  123 LYLKNVTPQDTQEFTCRVfmNTATELVKILEEVVRLRV 160
Cdd:cd20946  66 ITIKNVTRSDSGKYRCEV--SARSDGQNLGEVTVTLEV 101
IgV_CAR_like cd20960
Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and ...
 43-140 5.53e-03

Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins; The members here are composed of the Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins. CAR, which is encoded by human CXADR gene, is a cell adhesion molecule of the Immunoglobulin (Ig) superfamily. The CAR acts as a type I membrane receptor for group B1-B6 coxsackie viruses and subgroup C adenoviruses. For instance, adenovirus interacts with the coxsackievirus and adenovirus receptor to enter epithelial airway cells. The CAR is also shown to be involved in physiological processes such as neuronal and heart development, epithelial tight junction integrity, and tumor suppression. The CAR is a component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. The CAR is also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. The CAR is composed of one V-set and one C2-set Ig module, a single transmembrane helix, and an intracellular domain. This group belongs to the V-set of IgSF domains, having A, B, E and D strands in one beta-sheet and A', G, F, C, C' and C" in the other


Pssm-ID: 409552  Cd Length: 114  Bit Score: 36.27  E-value: 5.53e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7657220   43 AASAETEVGAMVGSNVVLSCidphrrHFNLS-----GLYVYWQIENPE----VSVTYylpykSPGINVDSSYKN-RGHLS 112
Cdd:cd20960   3 ITSAQTEIKKVAGENVTLPC------HHQLGledqgTLDIEWLLLPSDkvekVVITY-----SGDRVYNHYYPAlKGRVA 71

                        90       100
                ....*....|....*....|....*....
gi 7657220  113 LDS-MKQGNFSLYLKNVTPQDTQEFTCRV 140
Cdd:cd20960  72 FTSnDLSGDASLNISNLKLSDTGTYQCKV 100
IgV_MOG_like cd05713
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here ...
 105-161 8.43e-03

Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here are composed of the immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG). MOG, a minor component of the myelin sheath, is an important CNS-specific autoantigen, linked to the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). It is a transmembrane protein having an extracellular Ig domain. MOG is expressed in the CNS on the outermost lamellae of the myelin sheath, and on the surface of oligodendrocytes, and may participate in the completion, compaction, and/or maintenance of myelin. This group also includes butyrophilin (BTN). BTN is the most abundant protein in bovine milk-fat globule membrane (MFGM).


Pssm-ID: 409378  Cd Length: 114  Bit Score: 35.63  E-value: 8.43e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 7657220  105 YKNRGHLSLDSMKQGNFSLYLKNVTPQDTQEFTCRVfmntaTELVKILEEVVRLRVA 161
Cdd:cd05713  63 YRGRTELLKDAIAEGSVALRIHNVRPSDEGQYTCFF-----RSGSFYEEATLELKVA 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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