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Conserved domains on  [gi|115270953|ref|NP_056936|]
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zinc finger protein 117 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
163-475 1.83e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 1.83e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115270953 163 KPYKCKECGKAFNQTSHLIRHKRIHTEEKPYKCEECGKAFNQSST--LTTHNIIHTGEIPYKCEKCVRAFNqaSKLTEHK 240
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNSKSLPLSN--SKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115270953 241 LIHTGEKRYECE-ECGKAFNRSSKLTEHKYIHTGEKLYKCEECGKAFNQSSTLTTHKRIHSGEKPykcEECGKAFKQFSN 319
Cdd:COG5048  110 LSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN---SLSKDPSSNLSL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115270953 320 LTDHKKIHTGEKPYKCEECGKaFNQLSNLTRHKVIHTGEKPYKCGECGKAF-------NQSSALNTHKIIHTGENPHKCR 392
Cdd:COG5048  187 LISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsqSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115270953 393 eSGKVFHLSSKLSTCKKIHTGEKL-YKCEECGKAFNRSSTLIGHKR--IHTGE--KPYKCEE--CGKAFNQSSTLTTHKI 465
Cdd:COG5048  266 -PTASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                        330
                 ....*....|
gi 115270953 466 IHTEEKQYKC 475
Cdd:COG5048  345 LHTSISPAKE 354
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
163-475 1.83e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 1.83e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115270953 163 KPYKCKECGKAFNQTSHLIRHKRIHTEEKPYKCEECGKAFNQSST--LTTHNIIHTGEIPYKCEKCVRAFNqaSKLTEHK 240
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNSKSLPLSN--SKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115270953 241 LIHTGEKRYECE-ECGKAFNRSSKLTEHKYIHTGEKLYKCEECGKAFNQSSTLTTHKRIHSGEKPykcEECGKAFKQFSN 319
Cdd:COG5048  110 LSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN---SLSKDPSSNLSL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115270953 320 LTDHKKIHTGEKPYKCEECGKaFNQLSNLTRHKVIHTGEKPYKCGECGKAF-------NQSSALNTHKIIHTGENPHKCR 392
Cdd:COG5048  187 LISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsqSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115270953 393 eSGKVFHLSSKLSTCKKIHTGEKL-YKCEECGKAFNRSSTLIGHKR--IHTGE--KPYKCEE--CGKAFNQSSTLTTHKI 465
Cdd:COG5048  266 -PTASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                        330
                 ....*....|
gi 115270953 466 IHTEEKQYKC 475
Cdd:COG5048  345 LHTSISPAKE 354
zf-H2C2_2 pfam13465
Zinc-finger double domain;
152-176 3.47e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.47e-04
                          10        20
                  ....*....|....*....|....*
gi 115270953  152 LNKHKRIHTGEKPYKCKECGKAFNQ 176
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
163-475 1.83e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 1.83e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115270953 163 KPYKCKECGKAFNQTSHLIRHKRIHTEEKPYKCEECGKAFNQSST--LTTHNIIHTGEIPYKCEKCVRAFNqaSKLTEHK 240
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNSKSLPLSN--SKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115270953 241 LIHTGEKRYECE-ECGKAFNRSSKLTEHKYIHTGEKLYKCEECGKAFNQSSTLTTHKRIHSGEKPykcEECGKAFKQFSN 319
Cdd:COG5048  110 LSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN---SLSKDPSSNLSL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115270953 320 LTDHKKIHTGEKPYKCEECGKaFNQLSNLTRHKVIHTGEKPYKCGECGKAF-------NQSSALNTHKIIHTGENPHKCR 392
Cdd:COG5048  187 LISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsqSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115270953 393 eSGKVFHLSSKLSTCKKIHTGEKL-YKCEECGKAFNRSSTLIGHKR--IHTGE--KPYKCEE--CGKAFNQSSTLTTHKI 465
Cdd:COG5048  266 -PTASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                        330
                 ....*....|
gi 115270953 466 IHTEEKQYKC 475
Cdd:COG5048  345 LHTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
303-464 1.40e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 1.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115270953 303 KPYKCEECGKAFKQFSNLTDHK--KIHTGE--KPYKCEE--CGKAFNQLSNLTRHKVIHTGEKPYKC--GECGKAFNQSS 374
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115270953 375 ALNTHKIIHTGENPHK-----CRESGKVFHLSSKLSTCKKIHT----GEKLYKCEECGKAFNRSSTLIGHKRIHTGEKPY 445
Cdd:COG5048  368 NNEPPQSLQQYKDLKNdkkseTLSNSCIRNFKRDSNLSLHIIThlsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....*....
gi 115270953 446 KCEECGKAFNQSSTLTTHK 464
Cdd:COG5048  448 LCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
109-480 6.09e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 6.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115270953 109 FKCKECRKTFCMLSHLTQHKRIQTRVNFYKCEAYGRAFNWSSTLNK--HKRIHTGEKPYKC-KECGKAFNQTSHLIRHKR 185
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELsrHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115270953 186 IHTEEKPYKCEECGKAFNQSSTLTTHNIIHTGEIPYKCEKCVRAFNQASKLTEHKLIHTGEkryecEECGKAFNRSSKLT 265
Cdd:COG5048  114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115270953 266 EHKYIHTGEKLYKCEECGKA------------FNQSSTLTTHKRIHSGEKPYKCE---------------ECGKAFKQFS 318
Cdd:COG5048  189 SSNVSTSIPSSSENSPLSSSysipssssdqnlENSSSSLPLTTNSQLSPKSLLSQspsslsssdssssasESPRSSLPTA 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115270953 319 NLTDHKKIHTGE-------KPYKCEECGKAFNQLSNLTRHK--VIHTGE--KPYKCGE--CGKAFNQSSALNTHKIIHTG 385
Cdd:COG5048  269 SSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115270953 386 ENPHKCRESGKVFHLSSKLSTCK-------KIHTGEKLYKCE--ECGKAFNRSSTLIGHKRIHTGEKP--YKCEECGKAF 454
Cdd:COG5048  349 ISPAKEKLLNSSSKFSPLLNNEPpqslqqyKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSF 428

                        410       420
                 ....*....|....*....|....*.
gi 115270953 455 NQSSTLTTHKIIHTEEKQYKCDECGK 480
Cdd:COG5048  429 NRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
91-353 3.37e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 3.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115270953  91 HKISNSNRHKMRHTENKHFKCKECRKTFCMLSHLTQHKRIQTRVNFYKCEAYGRAFNWSSTLNKHKRIHTGEKPYKCKEC 170
Cdd:COG5048  181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115270953 171 GKAFNQTSHLIRHKRIHTEE-------KPYKCEECGKAFNQSSTLTTHN--IIHTGE--IPYKC--EKCVRAFNQASKLT 237
Cdd:COG5048  261 PRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALK 340

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115270953 238 EHKLIHTGEKRYEC--EECGKAFNRSS-----KLTEHKYIHTGEKLYKCE--ECGKAFNQSSTLTTHKRIHSGEKP--YK 306
Cdd:COG5048  341 RHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCK 420

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 115270953 307 CEECGKAFKQFSNLTDHKKIHTGEKPYKCEECGKAFNQLSNLTRHKV 353
Cdd:COG5048  421 NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
152-176 3.47e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.47e-04
                          10        20
                  ....*....|....*....|....*
gi 115270953  152 LNKHKRIHTGEKPYKCKECGKAFNQ 176
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
179-204 5.90e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.90e-04
                          10        20
                  ....*....|....*....|....*.
gi 115270953  179 HLIRHKRIHTEEKPYKCEECGKAFNQ 204
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
319-344 6.26e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.26e-04
                          10        20
                  ....*....|....*....|....*.
gi 115270953  319 NLTDHKKIHTGEKPYKCEECGKAFNQ 344
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 301-352 1.11e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.11e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 115270953 301 GEKPYKCE--ECGKAFKQFSNLTDHKK-------------------IHTGEKPYKCEECGKAFNQLSNLTRHK 352
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
292-316 1.56e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.56e-03
                          10        20
                  ....*....|....*....|....*
gi 115270953  292 LTTHKRIHSGEKPYKCEECGKAFKQ 316
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
347-372 1.81e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.81e-03
                          10        20
                  ....*....|....*....|....*.
gi 115270953  347 NLTRHKVIHTGEKPYKCGECGKAFNQ 372
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
435-456 2.18e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.18e-03
                          10        20
                  ....*....|....*....|..
gi 115270953  435 HKRIHTGEKPYKCEECGKAFNQ 456
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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