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Conserved domains on  [gi|7706657|ref|NP_056975|]
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pre-mRNA-processing factor 17 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 281-579 9.13e-64

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 211.04  E-value: 9.13e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657  281 IHVWSGHTKGVSAVRLFPlSGHLLLSCSMDCKIKLWEVYGERrCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWD 360
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657  361 TETGQCISRFTN-RKVPYCVKFNPDEDkqnLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFvDENRRFVST-SD 438
Cdd:cd00200  80 LETGECVRTLTGhTSYVSSVAFSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF-SPDGTFVASsSQ 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657  439 DKSLRVWEwdiPVDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRFrlnKKKIFKGHmvAGYACQVDF 516
Cdd:cd00200 156 DGTIKLWD---LRTGKCVATLTGHTGEvnSVAFSPDGEKLLSSSSDGTIKLWDLSTGK---CLGTLRGH--ENGVNSVAF 227

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7706657  517 SPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPhETSKVITCGWDGLIKLWD 579
Cdd:cd00200 228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 281-579 9.13e-64

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 211.04  E-value: 9.13e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657  281 IHVWSGHTKGVSAVRLFPlSGHLLLSCSMDCKIKLWEVYGERrCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWD 360
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657  361 TETGQCISRFTN-RKVPYCVKFNPDEDkqnLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFvDENRRFVST-SD 438
Cdd:cd00200  80 LETGECVRTLTGhTSYVSSVAFSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF-SPDGTFVASsSQ 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657  439 DKSLRVWEwdiPVDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRFrlnKKKIFKGHmvAGYACQVDF 516
Cdd:cd00200 156 DGTIKLWD---LRTGKCVATLTGHTGEvnSVAFSPDGEKLLSSSSDGTIKLWDLSTGK---CLGTLRGH--ENGVNSVAF 227

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7706657  517 SPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPhETSKVITCGWDGLIKLWD 579
Cdd:cd00200 228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
279-579 1.23e-56

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 195.52  E-value: 1.23e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657  279 KQIHVWSGHTKGVSAVRLFPlSGHLLLSCSMDCKIKLWEVyGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKL 358
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDL-ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657  359 WDTETGQCISRFTNRKVP-YCVKFNPDedkQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTS 437
Cdd:COG2319 189 WDLATGKLLRTLTGHTGAvRSVAFSPD---GKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGS 265

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657  438 DDKSLRVWEWDipvDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRFRLnkkKIFKGHmvAGYACQVD 515
Cdd:COG2319 266 ADGTVRLWDLA---TGELLRTLTGHSGGvnSVAFSPDGKLLASGSDDGTVRLWDLATGKLL---RTLTGH--TGAVRSVA 337

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 7706657  516 FSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETsKVITCGWDGLIKLWD 579
Cdd:COG2319 338 FSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR-TLASGSADGTVRLWD 400
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 306-488 2.63e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.02  E-value: 2.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657   306 SCSMDCKIKLWEVygERRCLRTFIG-HSKAVRDICFNTAGTQFL-SAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNP 383
Cdd:PLN00181 550 SSNFEGVVQVWDV--ARSQLVTEMKeHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPS 627

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657   384 DEDKQNLFvaGMSDKKIVQWDIRSGEI-VQEYDRHLGAVNTIVFVDENrRFVSTSDDKSLRVweWDIPVDFKYIAEPSMH 462
Cdd:PLN00181 628 ESGRSLAF--GSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSS-TLVSSSTDNTLKL--WDLSMSISGINETPLH 702

                        170       180       190
                 ....*....|....*....|....*....|...
gi 7706657   463 SMPA-------VTLSPNGKWLACQSMDNQILIF 488
Cdd:PLN00181 703 SFMGhtnvknfVGLSVSDGYIATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 322-360 1.27e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 1.27e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 7706657     322 RRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWD 360
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
322-360 1.75e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.73  E-value: 1.75e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 7706657    322 RRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWD 360
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 281-579 9.13e-64

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 211.04  E-value: 9.13e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657  281 IHVWSGHTKGVSAVRLFPlSGHLLLSCSMDCKIKLWEVYGERrCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWD 360
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657  361 TETGQCISRFTN-RKVPYCVKFNPDEDkqnLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFvDENRRFVST-SD 438
Cdd:cd00200  80 LETGECVRTLTGhTSYVSSVAFSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF-SPDGTFVASsSQ 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657  439 DKSLRVWEwdiPVDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRFrlnKKKIFKGHmvAGYACQVDF 516
Cdd:cd00200 156 DGTIKLWD---LRTGKCVATLTGHTGEvnSVAFSPDGEKLLSSSSDGTIKLWDLSTGK---CLGTLRGH--ENGVNSVAF 227

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7706657  517 SPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPhETSKVITCGWDGLIKLWD 579
Cdd:cd00200 228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
279-579 1.23e-56

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 195.52  E-value: 1.23e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657  279 KQIHVWSGHTKGVSAVRLFPlSGHLLLSCSMDCKIKLWEVyGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKL 358
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDL-ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657  359 WDTETGQCISRFTNRKVP-YCVKFNPDedkQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTS 437
Cdd:COG2319 189 WDLATGKLLRTLTGHTGAvRSVAFSPD---GKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGS 265

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657  438 DDKSLRVWEWDipvDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRFRLnkkKIFKGHmvAGYACQVD 515
Cdd:COG2319 266 ADGTVRLWDLA---TGELLRTLTGHSGGvnSVAFSPDGKLLASGSDDGTVRLWDLATGKLL---RTLTGH--TGAVRSVA 337

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 7706657  516 FSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETsKVITCGWDGLIKLWD 579
Cdd:COG2319 338 FSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR-TLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
279-579 9.84e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 185.11  E-value: 9.84e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657  279 KQIHVWSGHTKGVSAVRLFPLsGHLLLSCSMDCKIKLWEVYGeRRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKL 358
Cdd:COG2319  69 ALLATLLGHTAAVLSVAFSPD-GRLLASASADGTVRLWDLAT-GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657  359 WDTETGQCISRFT-NRKVPYCVKFNPDEdkqNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTS 437
Cdd:COG2319 147 WDLATGKLLRTLTgHSGAVTSVAFSPDG---KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGS 223

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657  438 DDKSLRVWEWDipvDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRFRLnkkKIFKGHmvAGYACQVD 515
Cdd:COG2319 224 ADGTVRLWDLA---TGKLLRTLTGHSGSvrSVAFSPDGRLLASGSADGTVRLWDLATGELL---RTLTGH--SGGVNSVA 295

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 7706657  516 FSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHEtSKVITCGWDGLIKLWD 579
Cdd:COG2319 296 FSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-KTLASGSDDGTVRLWD 358
WD40 COG2319
WD40 repeat [General function prediction only];
279-539 1.68e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 184.73  E-value: 1.68e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657  279 KQIHVWSGHTKGVSAVRLFPlSGHLLLSCSMDCKIKLWEVyGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKL 358
Cdd:COG2319 153 KLLRTLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRL 230

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657  359 WDTETGQCISRFT-NRKVPYCVKFNPDEDkqnLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTS 437
Cdd:COG2319 231 WDLATGKLLRTLTgHSGSVRSVAFSPDGR---LLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGS 307

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657  438 DDKSLRVWEWDipvDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRFRLnkkKIFKGHmvAGYACQVD 515
Cdd:COG2319 308 DDGTVRLWDLA---TGKLLRTLTGHTGAvrSVAFSPDGKTLASGSDDGTVRLWDLATGELL---RTLTGH--TGAVTSVA 379

                       250       260
                ....*....|....*....|....
gi 7706657  516 FSPDMSYVISGDGNGKLNIWDWKT 539
Cdd:COG2319 380 FSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
280-579 4.05e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 156.22  E-value: 4.05e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657  280 QIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGerRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLW 359
Cdd:COG2319  28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG--ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657  360 DTETGQCISRFT-NRKVPYCVKFNPDedkQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSD 438
Cdd:COG2319 106 DLATGLLLRTLTgHTGAVRSVAFSPD---GKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSD 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657  439 DKSLRVWEWDipvDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRFRLnkkKIFKGHmvAGYACQVDF 516
Cdd:COG2319 183 DGTVRLWDLA---TGKLLRTLTGHTGAvrSVAFSPDGKLLASGSADGTVRLWDLATGKLL---RTLTGH--SGSVRSVAF 254

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7706657  517 SPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETsKVITCGWDGLIKLWD 579
Cdd:COG2319 255 SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGK-LLASGSDDGTVRLWD 316
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 279-446 6.00e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 139.01  E-value: 6.00e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657  279 KQIHVWSGHTKGVSAVRlFPLSGHLLLSCSMDCKIKLWEVYGERrCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKL 358
Cdd:cd00200 126 KCLTTLRGHTDWVNSVA-FSPDGTFVASSSQDGTIKLWDLRTGK-CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKL 203

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657  359 WDTETGQCISRFTNRKVP-YCVKFNPDedkQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTS 437
Cdd:cd00200 204 WDLSTGKCLGTLRGHENGvNSVAFSPD---GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGS 280


                ....*....
gi 7706657  438 DDKSLRVWE 446
Cdd:cd00200 281 ADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
278-448 5.81e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 95.36  E-value: 5.81e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657  278 KKQIHVWSGHTKGVSAVRLFPlSGHLLLSCSMDCKIKLWEVyGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLK 357
Cdd:COG2319 278 GELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVR 355

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657  358 LWDTETGQCISRFTNrkvpycvkfnpdedkqnlfvagmsdkkivqwdirsgeivqeydrHLGAVNTIVFVDENRRFVSTS 437
Cdd:COG2319 356 LWDLATGELLRTLTG--------------------------------------------HTGAVTSVAFSPDGRTLASGS 391

                       170
                ....*....|.
gi 7706657  438 DDKSLRVWEWD 448
Cdd:COG2319 392 ADGTVRLWDLA 402
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 306-488 2.63e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.02  E-value: 2.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657   306 SCSMDCKIKLWEVygERRCLRTFIG-HSKAVRDICFNTAGTQFL-SAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNP 383
Cdd:PLN00181 550 SSNFEGVVQVWDV--ARSQLVTEMKeHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPS 627

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657   384 DEDKQNLFvaGMSDKKIVQWDIRSGEI-VQEYDRHLGAVNTIVFVDENrRFVSTSDDKSLRVweWDIPVDFKYIAEPSMH 462
Cdd:PLN00181 628 ESGRSLAF--GSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSS-TLVSSSTDNTLKL--WDLSMSISGINETPLH 702

                        170       180       190
                 ....*....|....*....|....*....|...
gi 7706657   463 SMPA-------VTLSPNGKWLACQSMDNQILIF 488
Cdd:PLN00181 703 SFMGhtnvknfVGLSVSDGYIATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 322-360 1.27e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 1.27e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 7706657     322 RRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWD 360
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
322-360 1.75e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.73  E-value: 1.75e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 7706657    322 RRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWD 360
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 277-317 3.26e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 3.26e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 7706657     277 PKKQIHVWSGHTKGVSAVRLFPlSGHLLLSCSMDCKIKLWE 317
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
278-317 1.95e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.95e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 7706657    278 KKQIHVWSGHTKGVSAVRLFPlSGHLLLSCSMDCKIKLWE 317
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 407-446 1.38e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 1.38e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 7706657     407 SGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWE 446
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 539-579 1.35e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.35e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 7706657     539 TTKLYSRFKAHDKVCIGAVWHPHEtSKVITCGWDGLIKLWD 579
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
408-446 2.84e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 2.84e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 7706657    408 GEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWE 446
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 497-536 5.42e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 5.42e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 7706657     497 NKKKIFKGHmvAGYACQVDFSPDMSYVISGDGNGKLNIWD 536
Cdd:smart00320   3 ELLKTLKGH--TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 286-423 8.18e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 42.24  E-value: 8.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657   286 GHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLR-------TFIGHSKAVRDICFNTAGTQFL-SAAYDRYLK 357
Cdd:PTZ00420  72 GHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDESVKeikdpqcILKGHKKKISIIDWNPMNYYIMcSSGFDSFVN 151

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7706657   358 LWDTETGQCISRFTNRKVPYCVKFNPdedKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNT 423
Cdd:PTZ00420 152 IWDIENEKRAFQINMPKKLSSLKWNI---KGNLLSGTCVGKHMHIIDPRKQEIASSFHIHDGGKNT 214
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
347-476 1.61e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.45  E-value: 1.61e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706657  347 FLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDedKQNLFVAGMSDKKIVQWDIRSGEIVQEYDrhLGA-VNTIV 425
Cdd:COG3391  83 YVANSGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPD--GGRLYVADSGNGRVSVIDTATGKVVATIP--VGAgPHGIA 158

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 7706657  426 FVDENRR-FVSTSDDKSLRVW--EWDiPVDFKYIAEPSMHSMP-AVTLSPNGKWL 476
Cdd:COG3391 159 VDPDGKRlYVANSGSNTVSVIvsVID-TATGKVVATIPVGGGPvGVAVSPDGRRL 212
WD40 pfam00400
WD domain, G-beta repeat;
541-579 3.50e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 3.50e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 7706657    541 KLYSRFKAHDKVCIGAVWHPHETsKVITCGWDGLIKLWD 579
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
497-536 7.18e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 7.18e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 7706657    497 NKKKIFKGHmvAGYACQVDFSPDMSYVISGDGNGKLNIWD 536
Cdd:pfam00400   2 KLLKTLEGH--TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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