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Conserved domains on  [gi|37594444|ref|NP_056980|]
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zinc finger MYND domain-containing protein 10 isoform 1 [Homo sapiens]

Protein Classification

zinc finger MYND domain-containing protein( domain architecture ID 10484396)

MYND (myeloid-Nervy-DEAF-1) domain-containing protein, defined by a C6HC zinc-chelating motif, does not bind DNA, but instead mediates interactions with other proteins

CATH:  3.30.60.180
Gene Ontology:  GO:0045892|GO:0008270|GO:0005515
PubMed:  19925420
SCOP:  4000530

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
zf-MYND pfam01753
MYND finger;
394-430 7.57e-14

MYND finger;


:

Pssm-ID: 460312  Cd Length: 39  Bit Score: 65.13  E-value: 7.57e-14
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 37594444   394 CAYCSAEASK--RCSRCQNEWYCCRECQVKHWEKHGKTC 430
Cdd:pfam01753   1 CAVCGKEALKllRCSRCKSVYYCSKECQKADWPYHKKEC 39
 
Name Accession Description Interval E-value
zf-MYND pfam01753
MYND finger;
394-430 7.57e-14

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 65.13  E-value: 7.57e-14
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 37594444   394 CAYCSAEASK--RCSRCQNEWYCCRECQVKHWEKHGKTC 430
Cdd:pfam01753   1 CAVCGKEALKllRCSRCKSVYYCSKECQKADWPYHKKEC 39
zf-HIT_ZNHIT1_like cd21437
HIT zinc finger found in zinc finger HIT domain-containing protein 1 (ZNHIT1) and similar ...
389-422 6.32e-03

HIT zinc finger found in zinc finger HIT domain-containing protein 1 (ZNHIT1) and similar proteins; The family includes ZNHIT1 and its yeast counterpart, the vacuolar protein sorting-associated protein 71 (Vps71p). ZNHIT1, also known as cyclin-G1-binding protein 1 (CGBP1), zinc finger protein subfamily 4A member 1 (ZNFN4A1), or p18 Hamlet, may have a role in inducing apoptosis through p53 signaling. It binds to Rev-erb beta and releases its inhibitory effect on the transcription of apolipoprotein C3 (APOC3) without affecting its DNA-binding activity. The yeast counterpart Vps71p, also referred to as SWR complex protein 6 (Swc6p), plays a role in the exchange of histone H2A for the H2A variant HZT1, a euchromatin-specific factor, leading to chromatin remodeling and transcriptional changes of targeted genes. It is indirectly involved in vacuolar protein sorting. Members of this family contain a zf-HIT domain characterized by a "treble-clef" fold through interleaved CCCC and CCHC zinc finger motifs, both of which bind a zinc ion.


Pssm-ID: 467791  Cd Length: 43  Bit Score: 34.52  E-value: 6.32e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 37594444 389 PERPRCAYCSAEASKRCSRCqNEWYCCRECQVKH 422
Cdd:cd21437   5 PPRKFCSVCGYWGKYTCVRC-GARYCSLKCLETH 37
 
Name Accession Description Interval E-value
zf-MYND pfam01753
MYND finger;
394-430 7.57e-14

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 65.13  E-value: 7.57e-14
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 37594444   394 CAYCSAEASK--RCSRCQNEWYCCRECQVKHWEKHGKTC 430
Cdd:pfam01753   1 CAVCGKEALKllRCSRCKSVYYCSKECQKADWPYHKKEC 39
zf-HIT_ZNHIT1_like cd21437
HIT zinc finger found in zinc finger HIT domain-containing protein 1 (ZNHIT1) and similar ...
389-422 6.32e-03

HIT zinc finger found in zinc finger HIT domain-containing protein 1 (ZNHIT1) and similar proteins; The family includes ZNHIT1 and its yeast counterpart, the vacuolar protein sorting-associated protein 71 (Vps71p). ZNHIT1, also known as cyclin-G1-binding protein 1 (CGBP1), zinc finger protein subfamily 4A member 1 (ZNFN4A1), or p18 Hamlet, may have a role in inducing apoptosis through p53 signaling. It binds to Rev-erb beta and releases its inhibitory effect on the transcription of apolipoprotein C3 (APOC3) without affecting its DNA-binding activity. The yeast counterpart Vps71p, also referred to as SWR complex protein 6 (Swc6p), plays a role in the exchange of histone H2A for the H2A variant HZT1, a euchromatin-specific factor, leading to chromatin remodeling and transcriptional changes of targeted genes. It is indirectly involved in vacuolar protein sorting. Members of this family contain a zf-HIT domain characterized by a "treble-clef" fold through interleaved CCCC and CCHC zinc finger motifs, both of which bind a zinc ion.


Pssm-ID: 467791  Cd Length: 43  Bit Score: 34.52  E-value: 6.32e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 37594444 389 PERPRCAYCSAEASKRCSRCqNEWYCCRECQVKH 422
Cdd:cd21437   5 PPRKFCSVCGYWGKYTCVRC-GARYCSLKCLETH 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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